skysight-inc/HackerNews huggingface dataset:
Seriously?

1- I was not the one claiming that the rest of the world is ripping off American drug companies.

2- the (obvious) point is that R&D isn't the major cost expense that was being posited in the original post. If cost of developing new drugs was inline with what the original post claimed, then you'd find both pharmaceutical companies profits being lower and fraction of expenses spent on R&D higher. Facts show otherwise, so primary cost of successfully doing business in pharma isn't drug development.

3- who said anything about marginal? Profit is profit. What we are discussing is the ethically justifiable profit rate. Pharma is one of the most profitable industrial segment in the US, with approx 20% net rate of return. As per the original article and related news stories show, these pharma companies are pricing many life saving drugs beyond what many can afford. At what rate of return is the pricing of life saving medicines no longer ethical? Please take into account that this is discussing how many people will be killed to protect/improve profits.
A great start for sure.

>Receiving significant investment of capital (at least $345,000) from certain qualified U.S. investors with established records of successful investments

Not sure what does the qualified US investors mean though. Would seed funding/angel funding from individuals not be considered for this? I guess this has been added to avoid abuse by wealthy foreigners, but how do they determine the qualified individuals or companies?
Yeah, Sigma and many other companies sell grams of epinephrine for ~$50. The expensive part is getting it in your body.

Actually, the EpiPen only injects 0.3 mg. Or around 0.4 cents worth of epinephrine if you could intake what Sigma is selling.

EDIT: I think I was off by a decimal place... Anyway, the epinephrine is more or less free. Just paying for the device.
That was a great write-up. I liked how you not only covered the technical details, but the human details, too -- how to get your idea noticed by python-dev, how to gain early adoption.
Interesting! I hadn't thought of it in the context of ADHD. For me, a person will always be more effective than an automated reminder. You can dismiss the reminder or ignore it. For a lot of people, lying to another person and saying "I'm working" when actually you're not is a pretty difficult thing to do. Doing the same to yourself or a bot is pretty easy.

In terms of qualifications, I don't think that they're that important. It's more important to find someone who, in pop psychology terminology, has a high EQ. Some people are just good at 'connecting' with a stranger and making them feel good/motivated, and customers will again want to meet deadlines set with someone like this. So yes, you could organize the equivalent yourself through outsourcing, but I reckon some people would use this as a more specialised service where they don't have to explain the role of PA to the person they outsource, and they know that the PA is competent in talking and being encouraging.

To keep people engaged, all the PAs will be really aiming to develop a solid relationship with each customer (I still keep in touch with my editor even though she no longer works at the publishing house). Thus the PAs are definitely going to be a lot more real than any automated solution (although long-term plans would be to partially automate a lot of their work!)

Thanks a lot for the random thoughts - they're really helpful in clarifying my own random thoughts, and I'll probably use some content from your comment to flesh out the FAQ if that's OK :)
Small Programs (2010)
> Gson and Jackson require you to write EJB-style objects to get automatic serialization

Not the case. I successfully used Jackson combined with Lombok to achieve some really nice DRY class definitions that Just Worked with Jackson. It took a little figuring out and a couple bugfixes to Jackson but it worked. That said, part of the hassle was that I insisted on being able to do this with @Wither so we could have the objects be immutable too.

Then you can write stuff roughly like

@Value
public final class Thing {
String name;
int age;
boolean boiling;
}

Although IIRC I had to use some other random set of lombok annotations instead of @Value to get it to work right with Jackson (this was a while ago, don't recall details)

> The problem with this approach is that you've completely abdicated the power of the type system to ensure that your objects are valid.

Yeah, this was a big problem with my approach. The other choice would have been to use @Builders instead of @Withers. Then you get a little more boilerplate (having to type .build()), but you can guarantee the built objects meet consistency requirements. (In retrospect, I doubt I chose the right tradeoff there)
Show HN: Card IQ – Transcribe Your Business Cards (powered by Scale (YC S16))
For what it's worth, in the support ticket exchange I did indeed offer to submit details of the attack vector along with proof that it's currently being actively exploited, for financial gain & at the direct expense of your customers.

I was basically told "you will be wasting your time"...
I am pretty sure this is satire. But this is the internet, so it is hard to tell.

To be clear: to an astrophysicist, "dark" means "does not interact with electromagnetic radiation except through the curvature of space-time by gravity". It only interacts with normal matter in that it affects gravity. It is otherwise completely transparent.

It does no mean "is not currently reflecting or producing visible light". Your closet does not contain dark matter when you close the door.
Yes, but that's why "alpha", "beta" and "RC" labels exist.
Some of the existing dysfunctional drug market dynamics can be addressed through a break up of the vertical integration: companies can choose to be the R&D/manufacturer in which case they are not allowed to market to doctors/consumers; or they can choose to be a marketer/distributor. Manufacturers must treat marketers non-discriminatorily.

This way we can separate the wheat from the chaff. Truly revolutionary products can still charge high patent-protected prices by their exclusive manufacturers. OTOH marketing driven products with weak perceived advantages won't be able to charge the high prices as they do now. In the Epi-pen case, the patent owner will still be the exclusive manufacturer. But if they raise the price by 400% to all the marketers the marketers may choose to promote other generic products instead.
Right, it's good for a weekend read. I wouldn't say it's completely devoid of educational value. It's interesting to see how Johnson manages his board relationships, as well as the details of the bidding process and how difficult it can be to form partnerships.

The late 80s were definitely a different time, though - the amount of money needed for the RJR LBO is much more easily accessible to people in similar positions in 2016. As of June 30th, KKR's AUM is $131B, while Blackstone is at $356B.

Another good read on PE is King of Capital (https://www.amazon.com/dp/0307886026).

If you're interested in learning the technical details of corporate finance, you're probably best off starting with something like the Coursera class Introduction to Corporate Finance (https://www.coursera.org/learn/wharton-finance), and then reading the textbooks referenced by the course for a more in-depth understanding.
Oh I certainly agree and fortunately this hasn't happened much to me. But it has happened to myself and many developers I know hence my original comment :)

Though to be fair I've also run into weird bugs with OpenShift, Mongo and a few others over the years so it's not necessarily something wrong that the developer is doing.
2016 H1B Visa Reports: Top 100 H1B Visa Sponsors
Am I the only person around here who is skeptical of all this added complexity?

Some of it is clearly very useful, but some of it strikes me as a tower of babel built upon workarounds to problems that have simpler solutions.

What I see here are several different vendors vying to make sure they remain relevant. While I understand this and even the need for it, I also understand that it can drive poor engineering decisions in the long run.
I'm ok with driving racists out of these kind of spaces, they can go hang out on reddit and stormfront and places like that.
Side note, brilliant marketing. This is such a hot-button topic, that although I disagree fundamentally with their solution, it will definitely have a lot of people talking about it.

I wish he had gone into more details about what counts as a "racist post." He seems to imply that people were just saying "black dude walking around." But would "black man peering into parked cars" also be flagged? And do those extra barriers, existing solely because of the word "black", lower the reporting rate of those kinds of posts?
Curse the law of law!!
Wow!!! So great. I have two international cofounders. So stoked.
More people need to know about this :(
That's not really what they're relying on. They're pointing out at the time of submission that race alone is not a useful description.
Not saying parking can't be built, just do not require parking minimums. Parking spots cost ~$10K and take ~180 sq ft of space + about half that again for access, or about the size of a small studio apartment. Parking garage spaces cost ~$20-$40K. If you have a parking lot, that limits the amount of land you can use for a building, and the number of spots limits the number of units (or sq ft for commercial/office). If you build a garage, you run into height limits, either from zoning or limitations of your construction method and materials.

Imagine if every room (not just bedrooms) was required to have a walk-in closet, because the American way is for people to have a lot of stuff and there's simply no way to provide for space if it's not mandated to be included in the cost and construction of every dwelling. It's be very convenient to have the space, but not everyone needs it, it would encourage people to buy and keep more stuff than they would choose if they had to pay, and it would reduce the amount of space available for anything besides closets.

But this is silly - people buy less, rent storage units, change habits, etc. Parking and transportation is the same. If your condo is $35K cheaper because there's no parking, and you forego a $35K car, then you save ~$1K/mo which pays for a lot of Ubers, delivery fees, and vacation cars. And if you want to have your own car, then you can always buy/rent a space!
100% agree! However (ok, so not quite 100% then ;)), I feel like if I jump right in with such an immature product and put a price tag on it, I won't even find 5 customers. Maybe I just need some more blind confidence, but I figured it would be useful to find 5 people outside of my immediate friend group to chat about the product in more depth with and get some feedback from them about whether they found the experience worthwhile.
On the other hand, this has already been done: https://en.wikipedia.org/wiki/List_of_directly_imaged_exopla...
Having the genome separated between multiple coinfecting particles is actually quite common among plant viruses.
5 Tips from Top Leaders on How to Manage Teams:
SDLang: Simple Declarative Language
I don't think it's unreasonable to assume that a lot of people complaining about others with race-based assumptions in an online forum ends up reinforcing each others' biases.

If the additional questions actually do encourage a closer examination of people's thoughts then it might even be effective, at reducing the prevalence of racist opinions rather than only heading off the increase the platform could have been facilitating.
Nextdoor "suspicious activity" reports were notorious for racist reports that should never have been made. "Everyone be on the look out! I saw a black man walking around in our neighborhood, possibly looking for houses to rob."

If the UI helps people realize that a black man walking down the street is not suspicious activity and should not be reported as such, then it is doing its job effectively.
Every time I hear "The industry is moving toward X", I can't help but imagine a car racing off a cliff at full speed.
Well, it looks like they define racist post as:

The company decided to define it as descriptions of criminal behavior that don’t have sufficient description, i.e. “dark-skinned man broke into a car” or a detailed description of someone, including race, that fails to describe them doing something sufficiently criminal.

I.e. it is a description that mentions race and lacks either: a) specific criminal behavior or b) other non-race details.

In this case, no wonder that forcing people to provide these details reduces number of such posts - it's practically guaranteed by the very definition!

I also wonder about this:

Nextdoor is aware of “two instances of racial profiling that had slipped through its algorithms in the last few months.”

Nextdoor is a pretty large network. And they have quite a lot of people there, tens if not hundreds of thousands at least. And only two cases of profiling in several months, less then one case per month over whole network? It's either nextdoor users actually are nearly saints in this regard, at least compared to regular population, or they are humblebragging, or the problem itself is really minuscule, or they are blind to it.
From a previous comment: https://news.ycombinator.com/item?id=12364958
I understand the value of an email address; I dispute the fact that it "works". Maybe it helps collect more email addresses than before, but the cost is bugging the hell out of every single visitor: is it worth it?
You can also surround each character in the program's name with square brackets.

ps -ef | grep [p][r][o][g][r][a][m]
Exterminating all mosquitoes could doom the animals that eat them.

Birds, insects, spiders, salamanders, lizards and frogs could lose their primary food source.

Wiping out a large part of the ecology could be a disaster.
Will machine learning outperform human curation in Apple Music?
Thanks for the link. Do you mind sharing some of these other all-time favorite survey papers?
GitLab CI: Deployment and Environments
I just switched to running my software's email from my personal mail server when Mandrill died. Setting up your own mail server is a pain in the ass but it has paid off 100x imo.
3. The problem is, if you say that Pharma profits s/b illegal, the companies will simply stop risking money on figuring out new treatments. The European governments ride their high horses and refuse to pay a fair price for private pharm company inventions, BUT they also refuse to make meaningful contributions themselves - which is WHY there's such a huge private pharma industry in the first place.
Regarding the "no massive dark bodies" result: does this also cover dark dust? Or is that otherwise ruled out (perhaps by optical density)?
The blog post notes that the Safari that is driven by the automation cannot interact with other windows or user preferences. It also requires that the user has had the "enable remote automation" enablex, which is only possible if you have enabled the developer menu bar.

In addition, automation windows are shown with a different coloured bar and have a "pane" over the window so that it won't receive stray mouse or keyboard input.
I really hate the kind of “Privacy made in Germany” way of marketing, especially since I am german.

Mailbox.org seems decent from what I've heard but products advertised like this are mostly sheer bullshit. I don't know why transferring a “quality” label from (oldschool) engineering products to IT even works.
Climbing the wrong hill
Kubernetes and Google Cloud were both informed by the design and implemention of Borg. Kubernetes is basically for all intents and purposes Google Container Engine. That's fine, but it;s highly tuned for how google sees the world.
Exorbitant Deals in Tech Industry
What will happen after the 5 years stay ? Should the entrepreneur pack up and leave ? Why should an entrepreneur startup something when he/she is not sure about their residency in US. This rule says 'parole' & self petition, the residency path is not clear. And when it comes to residency, US immigration for skilled immigrants is so broken that you will regret applying for one.
The Potential Future of Apple Watch
How do you rectify these numbers?

The sun is 99.86% of the mass of our solar system and is quite average. [1]

Dark matter is ~27% of the mass of the observable universe. [2]

Are you claiming that exoplanets and asteroids represent 27% of the mass of the universe when a typical G-type star (not particularly massive, by any means) is almost 100% of the mass of our entire solar system?

I'm confused by your assertion - you either have some data I am lacking, have entirely made up your post, or are, yourself, confused.

[1] https://en.wikipedia.org/wiki/Sun
[2] https://en.wikipedia.org/wiki/Dark_matter
I have an O1 and go through secondary every single time I enter the states. Budget a couple of extra hours when traveling to the US and you're fine. After you do it a few times and the agents see you're on the up and up the process goes quite quickly.

Relative to the effort of getting an O1 or chancing your fate to the H1-B lottery this is huge.
Don't France and Germany want to put backdoors in encryption?
> http://www.wsj.com/articles/france-germany-push-for-access-t...
Two of my most favorite books tries to shine light on some of the different aspects of your (first) question. Maybe the unexpected findings during the pursuit of this question will be as fascinating to you as it was to me.

The Mating Mind: How Sexual Choice Shaped Human Nature (2000) (Geoffrey Miller)

The Red Queen: Sex and the Evolution of Human Nature (Matt Ridley)

https://en.wikipedia.org/wiki/The_Red_Queen:_Sex_and_the_Evo... https://en.wikipedia.org/wiki/Geoffrey_Miller_(psychologist)...
Exoplanets and asteroids don't explain the discrepancies. There aren't enough of them. Our galaxy appears to have about 20x more dark matter than regular matter, yet our solar system has about 99.9% of its mass concentrated in its star. There's no indication other star systems with planets are radically different in that respect. If there was enough of this stuff to make up the discrepancy, there would be enough of it to see it.

There's also apparently decent evidence, based on things like irregularities in the cosmic microwave background, that most dark matter isn't any form of baryonic matter.
Attributing somebody specific stereotypic behavior based solely on color of their skin (implying race) is the very definition of racist. Of course, if you talk about specific individual's behavior pointing it out is not racist. But if you say that individual is doing so because he belongs to a certain race and you would expect the same behavior from any representative of the same race because their race defines their behavior - yes, this would be textbook racism.
Threatening voters with hell: “Spiritual blackmail” in politics
The Hope and Hype of AI
The whole premise of this article is flawed. There is nothing divisive or puzzling about pursing intellectual work and trying to make the world a better place. The only puzzle is how he finds the energy to do it all.

It also didn't really convey just how critical the scientific community is of Wolfe's take on linguistics. There's a pretty good takedown here: http://facultyoflanguage.blogspot.co.uk/2016/07/the-sludge-a...
I wish having an advanced degree was a criteria here. A few years ago, I noticed that Britain would give a blanket visa to anyone with an MBA from a list of top international schools. How about something like that for people with Masters/PhDs (in STEM) from top-50 schools in the world.

That said, the proposed rule might mean if one gets into YC/techstars, etc. they would be able to get a visa for the US easily.

The limited term and renewals do raise some flags. But I guess if you are successful with your startup in the given time period, you can apply for a green card through other categories like Extraordinary Ability, etc.
I never understood this, why do people hate gentrification?
Yes, I was thinking this exact thing. They're making things better on one metric, but (possibly) making things worse on another. The article doesn't really address the issues of false positives.
According to the docs: yes. https://developer.apple.com/library/prerelease/content/relea...
Well, to be fair, here we have a neutral media source calling Chomsky the most important living intellectual. Seems to fit Moldbug's curious side-note.
Note that 27% is of the total mass and energy, where ~68% consists of dark energy. If you ignore dark energy and just look at matter, dark matter is about 85% of the total. Which is pretty crazy! We have no real idea what 5/6ths of the stuff in the universe actually is!
Do play their game. Raise the costs of your opponent.
upvoted, and not disagreeing (b/c i know nothing a/b this) -- would like a similarly semisimple explain on how "interaction" thru gravity alone makes any sense at all in the relativity framework: light no longer travels along lines of zero acceleration?

Edit: on second thought, a book reference is probably better
QNX is a microkernel done right. For three years I used it as a desktop OS while doing real time development. Firebird (a predecessor of Firefox) and Thunderbird ran, so I had browsing and mail. Running QNX on a desktop is a smooth experience. There's no paging, so there are no paging delays. It has real-time responsiveness, so there are none of those brief stalls you get with Unix and Linux.

QNX's problem is the ownership. The business has been sold twice (to Harmon, an audio company, and to RIM/Blackberry). The code has gone from closed source to free version available to closed source to open source to closed source with no free version. Third party developers were so fed up they stopped developing for it. Now QNX no longer supports itself as self-hosted; you have to cross-compile from Windows.

The problem with the Hurd is that they tried to take a big OS, Mach or BSD, and make a microkernel out of it. Mach itself started with BSD and tried to make a microkernel out of it. Wrong approach. You have to start from nothing and build a minimal microkernel.

All QNX has in the kernel is CPU dispatching, memory management, timers, and message passing. Everything else is in user space. To get things started, the boot image can contain user programs which are loaded during boot and then started. That's how the initial drivers and file systems get loaded. For many embedded applications, that's all that gets loaded - there may not be a file system. For bigger systems, the initial drivers are just enough to allow loading more stuff from disk.

It's annoying that nobody else, with the possible exception of the L4 people, seem to be able to get this right. The QNX kernel is only about 60K bytes of code.
Hybrid cars don't necessarily have an alternator in the sense that an all gasoline car does-- for example, Toyota's hybrid system uses a pair of motor/generators (electric motors which can be configured to generate power too) connected to each other and to the gasoline engine through a planetary gearset.
Is Cristiano Ronaldo in decline?
Agora.io Is Poised to Dominate Real-Time Voice and Video Apps