skysight-inc/HackerNews huggingface dataset:
As with just about everything to do with chemistry and drug development, the answer is "maybe".

It depends on the model, it depends on the failure, it depends on so many different factors.

For example, it may be that in human trials the new drug X is better than nothing, but not as effective as an older, generic drug A, which costs $0.10 per pill.

That's a market failure, but it's not possible to feed that back into the model.

Or, look at the TGN1412, where all 6 volunteers for first-in-man Phase 1 tests has to be hospitalized; 4 with multiple organ disfunctions and may never fully recover.

That doesn't require a simple fix to the existing model, but a investigation into how the underlying mechanism works.

But in general, yes, absolutely the information is fed back into the development process.

That said, I can make no sense of your analogy to unit testing. Drug molecules aren't meaningfully decomposed into individual units that can be tested, and a modification in one structure which may be deleterious may be beneficial if done to another structure. There are rules of thumb ("Rule of 5", "magic methyl"), and more statistics-based model ("Free-Wilson model", "matched molecular pairs"), but they do not ensure that there will/won't be a problem, only enrich the likelihood of finding what you are looking for. Hopefully.

Based on what you've written, including your lack of knowledge of QSAR, no, I don't think you know much about drug development.

You have a new account, so I will explain what my comment means. At HN, the readers are also semi-moderators. By making my comment, I was doing the first step towards "contact[ing] the administrator", and letting the submitter (that is, you), know that it is a poor fit for HN.

The HN guidelines say that topics should be on "Anything that good hackers would find interesting." I am a good hacker. I also write software for drug development. I did not find the piece to be interesting. I found it to be dismissive of the hundreds of thousands of people who have worked in drug development, and long ago put iterative processes and quality control methods in place.

I guess if you don't like my comments, you too can file a complaint with the administrator. I will continue to criticize articles that I think have little understanding of topics that I know something about.
Single-Atom-Thick Sheets Efficiently Extract Electricity from Salt Water
It seems like the weak spot for using Julia outside of scientific computing is deployment to interesting targets.

For example, with Go you can build a standalone executable in many platforms, and other languages run on interesting targets like browsers or phones, or run on the JVM.

Any news on that front?
I can give my personal take on working as a software developer in St. Louis. Ten years ago, it was pretty hard to find cutting-edge work. Developers here usually went to work writing code for Boeing or AT&T or Edward Jones, etc. (I worked for AT&T.)

But that's an outdated view of the world.

I now work for a medium-sized software company. I have multiple friends here who work at little web/mobile consultancies. There is even a smallish startup scene and an incubator [0].

Obviously, it's not on the scale of New York or Boston or SF, but it's large enough to render your comment absurd.

[0] http://www.downtowntrex.org/
Show HN: Vandium – telemetry and security for AWS lambda
Which people are you talking about? This is done pretty regularly but generally judicial review tends to favor conservative interests.
Just throwing in some thoughts...

Mormon eschatology is pretty thin but the core beliefs are that the people are of "one heart and one mind" and that "there are no poor among them".

Specifically this mean that Zion can only be built from "within" and not by force of arms and an economic system not based on self interest but on "love thy neighbors as thyself".

Early Mormon's made attempts in Kirtland Ohio and Far West Missiouri which mostly failed due to rampant speculation and broader economic panics. Some of the ideas were adopted in Nauvoo, Illinois and later is small communities in Utah by Brigham Young.

Some of these experiments yielded later economic benefits because it allowed the Mormon's to divorce their economic system somewhat from gold (which was I short supply). While trades with non-Mormons would need to be settled with gold trade between Mormons could be settled with script that could be exchanged for goods at the "bishop's storehouse." Tradesmen and famers would sell items to the storehouse and get back script which they could then use to buy finsished good or services.

This created a currency that was functionally backed by finished goods and commodities and was immune to speculation and banking system panics that were common at the time.
> find out

What is the wire format of the telemetry data? How do I access the UI that tells me exactly what telemetry has been sent to Microsoft?
Enterprise users get a 4th option called "security" for telemetry I think (which in gpedit is option 0 I believe). I think it sends even less than basic and as the name implies it only sends security relevant telemetry (Defender, MRT, etc).
I live in Michigan and work for a company in SV. I love it in general but feel like it's pretty unlikely that I'd be able to find similar situation if I were to lose my job. It's not the best position to be in.
The kernel has heavy development from the US. If their intention was to think they were running complete on things not developed at least partially in the US, then they were really off the mark. Huawei even blatantly steals software for their network hardware from US companies.

If they just meant the last piece of physical hardware sold by an American headquartered company, then I guess that's something?
What a Pokémon Go Experiment Taught Us About AR Marketing
> their paid video content

There are a large number of situations where you have to break protection mechanisms on content you've legally purchased in order to exercise your previously existing and legal rights to use it as an owner.
Why Writers Should Manage Your Tech Products
Libyojimbo: Library for creating secure client/server network protocols over UDP
For a dynamic set of properties, an observable dictionary is better. For a fixed and known set of properties, its possible to enumerate them with "@observable" decorators beforehand (e.g. see MobX)

Method missing is an alternative to proxies, not a feature.

IMO, a lot of use cases for proxies are mistakes and/or better handled without them.
Monotype acquires Olapic for $130M
Ohlife
I created this little iOS app for my blog to deal with non subscribers
No no. If you trade something on margin or borrow money, in many countries like in the UK, all the marketing material has to clearly state the risks. All mortgage ads have a big banner "if you do not make your payments your house may be repossessed". A derivative contract with a mid-size company is now deemed missold if the marketing material doesn't highlights adverse or worst case scenario.

These are not font 6 footnotes in the terms and conditions.
China could learn a lot from FB about social surveillance..
I wouldn't place Raleigh in the same league as NY, LA, SF, WDC, Chicago and Boston. These have 5-fold or more the population density than Raleigh.

But the distance metric would stick: if you can leave ~7 miles (15 min) outside Raleigh and afford a good land, it compares with Boston area (5-fold pop. density), with 35 miles outside for a house on 1 acre land, and about 75 minutes commute during rush hour (would drop to 35 minutes outside rush hour).
China's Short-Changing Its Future
Interesting project. I hadn't come across this one yet. One difference that riko has is it's based around functions whereas this library (and practically every stream processing lib I've come across) is based around classes.

I personally prefer the functional approach much better. And if you compare the word count examples on the respective readmes [1, 2], you will see riko is much more succinct. But I suppose the verbosity of the other libraries come with benefits like scaling across a cluster of servers.

[1] https://github.com/plecto/motorway#word-count-example

[2] https://github.com/nerevu/riko#word-count
I can see them all at once:
https://letsmonitor.org/images/landing/laptop.png
This may be relevant: http://m.youtube.com/watch?v=xzYgiOC9cj4
I can't wait for that announcement, because I'm going on a full throttle stock buying frenzy in that instant.
I hope they release a private enterprise version, like they have for StackOverflow[0]. I'd love to host this on-prem to document my company's codebase.

Anyone know of a similar solution that's available now?

[0] http://meta.stackexchange.com/questions/16054/is-the-stack-e...
Show HN: Vandium – secure your serverless infastucture
Donald Trump, Peter Thiel and the Death of Democracy
So if its nowhere, what's the resistance about? Vermonters want to do whatever the hell they want on their own land. But not this guy? He's got to do what Vermonters want? I never figured out what that's all about.
Yep. Just pass in a comma delimited list to the subdomains parameters (subdomains=www,hello,another,test) and it'll add all of them to the certificate.
Node-RED is pretty great. I think a wiring interface is a better choice than a block-level thing like blockly.
I think MithrilJS has the best trade-offs. You get insane speed without insane complications.

I dread ever having to write ReactJS again as the entire setup is quite gross. The sliver of speed in ReactJS is not worth the bloat.
If a Maniac has made unauthorized modifications - Maniac gets sued and does jail time. Tesla is fault free.

You shouldn't be able to sue a tool manufacturer for misuse of a tool.

If you cannot sue Mercedes for a case when a driver with after market tuning kills someone in a crash, why should Tesla be liable?
I'm not getting that for some reason, so I can't test it on this, but if they just ask for an e-mail address then they typically don't do any verification up front, so you can just "register" with pouihasfgdiuh@oijsdfoiujsdf.com to make it go away.
Code Utopia – A Checklist
Can KickassTorrents Make a Comeback?
Is this outgoing manager already gone? If not, see if you can talk to him/her. Take that story, and the story you get from the people hiring you, and average them.
Ironic is applying for a job at a company building one of those services and being told they don't offer remote positions.
Alaska, Arizona, Vermont and Wyoming
The people, citizens. Though i'm curious what kind of laws are rolled back in the US because a citizen decided to sue to government. Do you have any nice examples (preferably of some law effecting many but sued by just one person?)
I've heard this opinion that technology never disappears. Like there are users even for the most primitive technology.
This post about the damage inflicted by 1201 reminded me of another 1201: Halon 1201, banned because it depletes the ozone layer. A serendipitous coincidence, with this post talking about 1201 like an ecological threat.

More seriously, the GPLv3 contains an interesting provision. Search for "Anti-Circumvention" in this to find the section: https://www.gnu.org/licenses/gpl-3.0-standalone.html

The second paragraph is probably enforceable, but I'd be interested to hear from someone suitably informed whether the first paragraph has any basis. How far can it be taken?

For example, one of the most insidious things about the Blu-ray format is that unlike DVD and HD-DVD, commercially pressed video Blu-rays are obliged to use AACS. Theoretically non-AACS discs could be pressed and work, but the replication plants aren't _allowed_ to print non-AACS video Blu-rays. This has caused some consternation where people want to distribute Creative Commons/etc. video on optical media, more than can fit on a DVD. I think I recall Archive Team talking about just having to resort to putting video files on a data Blu-ray instead.

If someone made a film, put "Neither this work nor any derived work can constitute an effective technological measure for the purposes of the WIPO copyright treaty or any corresponding legislation" in the credits, and then someone else got AACS'd Blu-rays made of it, would 1201 thereby not prohibit breaking AACS specifically in the context of that Blu-ray? It seems rather dubious.
A ride in an autonomous vehicle should be far less expensive than a ride in a manually driven Uber vehicle.

If the end goal for both is a fleet of autonomous vehicles and a strong app to facilitate the use of that fleet by the public, I would much rather be in Tesla's position. Having a fleet and needing to create an app sounds a lot more promising than having an app but no fleet. Tesla will be able to get an app up and running far sooner than Uber will be able to get a fleet.
Really cool. Do you know a list of similar repos for other stacks? C#+JS? Java+JS? ...etc
> What happens if we let people modify their microwaves and a terrorist uses his to give kids cancer!?!?

I know this was said in jest, but given the (generally unfounded) fears some people have about microwaves and cellphones I want to point out that exposure to unshielded microwave radiation isn't going to cause cancer (at least not any more than anything else that heats you up could somehow cause cancer) because microwave radiation is non-ionizing; you would need at least ultraviolet light for that (and UV-C or X-rays would be most effective).

The biggest danger with strong microwave radiation would be boiling your eyeballs as they lack the cooling most of your body has but contain significant amounts of water.
A retrospective on the ND oil industry boom and bust
I switched to Ubuntu because of Windows 10. Using Linux as a primary operating system works great as a developer.

There is a saying which says if a product are free "you are the product". Microsoft made the upgrade to Windows 10 free a guess so that they can mine data about you and your habits. That data is valuable for marketing purposes.

Wireshark traffic dumps show a lot of data going to Microsoft telemetery.

I choose to say no to that data collection, instead wanting to keep a bit of privacy.

Have some security wiz MITM the Microsoft telemetry server with their own cert to inspect the data collection traffic?
Effectively breaking the immutability of a blockchain's history might be financially rational[0], but it appears unprincipled to do so after leadership spent a couple years extolling the virtues of "code is law" and "code is contract."

I'd like to learn what principles are now now guiding the development team, since "code is contract" has apparently been abandoned. After this episode, it appears (from the outside) that it will be more financially beneficial for any project using the Ethereum blockchain to aggressively pursue investment from core developers and 15% of the token holders than to ensure the correctness of their code. In my view, this fatally undermines the value proposition of both said hypothetical project and Ethereum itself.

For many people, "perception is reality." I know that media often unfairly frames their reporting, and in this case everything I've seen reported has been the seemingly arbitrary and seemingly self-serving nature of Ethereum development. I would be happy to be shown what I've read is wrong and that the philosophical foundation of Ethereum development is sound, consistent, and impartial.

[0] Certainly for a subset and the short term, arguable for all and the long term.
Pandora Quite Literally Bought the Quarter
Wow and did you see that model community? All about work and money; no place whatsoever for recreation or privacy. A warren of worker bees farming and sweating - his "utopia"
Doesn't seem eco-friendly or world changing but more consumerist to me, can the batteries be recycled then?

Note: I'd still like to believe in Tesla's world improving ambitions
Its hard to explain properly (doesn't help that english is not my first language). Its small little gimmics that make the whole experience. The way windows present themself next to each other when your press the Super key and the way how this sorting is somehow consistent. They way how the sort order can change based on the focused window. The way ALT+TAB offers grouping if wanted. Its really worth the try. I never felt as focused before and my mac at work feels like a bad joke UX wise.
Are you implying that you can't scientifically study the climate because some of the predictions it makes aren't falsifiable? That does not seem like a particularly useful argument.
The social contract is such that people can reasonably be assumed to be ok with a minuscule increase in risk in order to get a dying person to the hospital.
> I'm still kind of surprised this hasn't been reverse-engineered.

Yeah. Maybe another sign of Microsoft's increasing lack of relevance if no enterprising hacker cares to investigate it.
Whether the purpose of legislation matters very much depends on a judge's beliefs regarding statutory interpretation. Enforcement of a statute is often all about the purpose of it. That said, I see your point and its a valid one. I'm just not sure I believe getting rid of 1201 will do less harm than good. I guess we'll see how the lawsuit turns out!
9 Tips for Getting Your First Software Job
I do not know much about Vermont however it seams like a good place, it is said in the article "you have selected the most incongruous place imaginable"
Setting aside Indifference, Where would be a more congruous place?
Sounds like a startup!
Good to know, now I'll have something to say to my mom the next time tells me to back away from the microwave while it's on...
I think this is an important topic that needs to be addressed, but suing the government is doomed to fail. The federal government has sovereign immunity, and you can't sue them unless they decide that you can. They usually decide that you can't. Most laws aren't changed in the court unless someone is criminally prosecuted. Then your appeal case can move through the higher levels of the court until it reaches a level that the law can be struck down completely, or what usually happens is a legal precedent is set regarding a specific portion of the law.

So unless Bunnie has been prosecuted for breaking the DMCA, this is likely going to be an ineffective move.

If you want to change a law without breaking it first, the right way to go about it is petitioning Congress, the lawmaking part of the government.
My intuition [maybe that's not knowledge] is that the application would require a portfolio of stock images, hence the photographers are almost certainly already in other stock image sales channels. There's little reason to assume that they will drop those other channels.

Because of the ownership model of Stocksy, there's little reason to bring on photographers without an existing track record selling stock images.
It's https://en.m.wikipedia.org/wiki/Endowment_effect
In my experience, those nitpicks and deletionists only agro at things they don’t understand, like any sufficiently complex question or topic.

I think PHP is going to be documented really well, I anticipate hundreds of wonderful examples how to get a substring or format a date-time from MySQL query result.

I doubt there will be much content outside of that.
They moved to Utah, once. This seems like exactly the demographic that has, historically, been willing to move to the wilderness for idealism.
List-Unsubscribe in email's header
That's why German products exported to the United Kingdom had to be marked with "Made in Germany" (roughly 125 years ago).
True, Node-RED is much more aligned to the original Yahoo! Pipes interface. I kinda like the scratch/blockly interface since you can make it clear which components can go where. Plus it's reminiscent of physical Lego blocks.

Which interface do you think is more newbie friendly? My gut says blocks (maybe something a bit more simple/refined than blocky) are easier to grok, while wires allow for designing more complex workflows.
Not necessarily. It can influence the change in legislation or enforcement thereof. Case in point: DJB vs. United States

https://en.wikipedia.org/wiki/Bernstein_v._United_States
Interesting point. Is this how the rulings are going right now?
You skipped the part where you form a lobby group with deep pockets before petitioning congress. I'm skeptical that petitioning will be any more effective than a lawsuit without that step.
Sure he sponsored the roads, but the government implemented those roads. Planning, buying, organizing, maintaining, etc are all part of the work that the government does.
Is it that China hasn't innovated in anything recently, or is it merely that you are not aware of it?

There certainly is a lot of copying. Most Americans feel ashamed to just rip off someone else's idea and run with it, but that sentiment doesn't exist in China. The result is a lot of shameless copycats, which is often interpreted as a lack of innovation. But not all Chinese ventures are copycats, and the copycats can end up innovating too.
> the keylogger aka the helpful keystroke correction

Why do you naturally assume malicious intent? Is the Android Keyboard (which does the same thing) a keylogger? What about every search engine's suggested searches?

Did you know that OSX's Spotlight feature sends your queries to Bing by default? If Apple is so protective of your personal information, why on god's green earth would they choose big bad Microsoft as their default search provider for OS level search?

There's this dichotomy that exists between Microsoft and everyone else. Microsoft can do no good, and everyone else is given benefit of doubt. Google's search assistant cross references a search you made on your desktop Firefox browser with a contact in your Android phonebook and suggests a Google Now car based on it and your response is "Thanks Google!". Microsoft grants it's search assistant access to it's contacts app on your device so that if you type your friend's name in the Windows 10 search bar it can display his contact info and you lose your mind. How is that fair?
I built an asset compiler http://jooby.org/doc/assets on top of j2v8. It runs jshint/ugligy/babel... without installing node.

The asset compiler has a maven plugin, so from Java developer perspective is very very useful.

Now with node.js on the JVM will play and see if my asset compiler to use grunt now.

Thanks Ian!
Missing a comma perhaps? I first misread it as chicken odor prevented researchers from doing their job since it smelled so bad.
I guess my definition of innovation is different? From what is described in the article, I see China using western technology to copy western software and web tech, while at the same time blocking competing platforms.

Not to say that I think China can't innovate, just that I don't think the article gives any examples of it.
Recently Jack Ma claimed that China is delivering "low cost- better quality" products than USA;
SoftBank are Japanese, not Chinese.
i think it relates to this:

[1] http://www.wired.com/2015/04/dmca-ownership-john-deere

[2]https://theamericangenius.com/business-news/farmers-cant-leg...

it seems to concern the idea, as mentioned above, of ownership vs a permanent license of the goods purchased or in their minds.. leased?
I recommend disabling some of the Amazon integration in Unity if you're concerned about your privacy. This shouldn't be too difficult, even if you're new to Linux. I 'd also suggest getting Unity-tweak-tool and playing around with some of the settings in there.

EDIT: Just realized that since 16.04, Ubuntu no longer has online search results enabled by default in the Dash. Still though, play around with some of the settings!
This article is an argumentum ad absurdum of how the Ethereum hard fork yesterday was justified, see https://news.ycombinator.com/item?id=12128866.

Basically, it's trying to say that if you're OK with the Ethereum hard fork, you should be OK with this BIP intended to give Ross Ulbricht (who operated the Silk Road) the Bitcoins back the FBI confiscated from him. Which is obviously absurd.