skysight-inc/HackerNews huggingface dataset:
All pretty niche services mostly in the real estate and home improvement type sectors. None have/had the potential to really be unicorns but all have/had the potential to be million dollar+ businesses.

I didn't start off hiring employees. In the beginning I did everything myself (programming, marketing, customer support, accounting, etc.). A year in I hired my first customer support employee and throughout the years employee count fluctuated from just a couple to 13 at most. Many of which were part-time and worked remote. I have also had offices throughout the years but now focus totally on remote. I don't like the burden of an office.

I think my #1 tip for a newbie would be to look for something niche that solves a pain point or allows your customer to make or save money. For example: if your customer can spend $10/mo on your software and make or save $30/mo from that, you will have no problem getting & keeping customers.

#2. Don't focus on becoming a unicorn. You can make some serious money and build a very comfortable life running a $300k to $1m dollar business, and your chances of succeeding at that are much greater.

#3. Look for things outside of tech. There are so many problems to solve in small businesses. Many will say there is no money to make with small businesses. My response to that is re-read #2.

#4. Learn everything you can about advertising. Get really good at it and be willing to spend money on advertising.

#5. Be willing to kill something off quickly if it doesn't make money. Test your market early to make sure people will pay for it. I have made the mistake of not doing this and I have lost a lot of money because of it. Now, I need to be able to see a positive ROI on my spend within 3 to 4 months. So if I spent $100 to acquire a customer, I want to be able to get that back + more within 3 to 4 months. I know this timeline is probably really short for a VC funded company, but I have always been bootstrapped so don't have the luxury of risking a longer time-frame for return.
I just wrote the TOS myself and run my site as a sole proprietor. $0 in legal bills.
NIH Should Replace Peer Review with a Lottery
Schizophrenia and poor neighborhoods: revisiting causation using genetics
And it would certainly be even higher if we didn't regulate the hell out of automobiles and driving to make them safer and prevent fatalities.
Genetic contributions to self-reported tiredness
It's kind of funny that the blogger puts "those who speak do not know" at the top of one of his articles where he apparently has quite a bit to say.
What is your bounce rate? Did you do anything like SEO?

If you have a high bounce rate, you might want to show the user a demo of how the product works.
> Most of the food comes from about 20% of the farms; the rest are marginal producers. Farming is doing fine; it just doesn't take many people.

Better food is more labor-intensive. The best-tasting eggs I've ever bought were from a grass-fed beef farmer. He'd rotate his cattle through the pastures, and move the chickens to where the cattle had been previously. The chickens would stomp through the cow waste, and eat all the bugs.

Industrial food is tasteless.
Precisely. Reminds me of Skolkovo which ended up being a huge money laundering scheme instead of a high technology innovation center.
But if the individuals who have the greatest expression or concentration of these genes are having children less frequently (because they are no longer pressured into having children by their relatives/community), then this will act as a siphon for those genes over many generations. That doesn't mean that they will completely disappear, but that these genes would become much less prevalent.
> But they have all the same design problems of monorails (the worst and least expandable form of public transportation). Difficult to switch lines and difficult to extend. Also you get the additional difficulty of turning, which apparently is very difficult in ETTs.

I see the fan group for monorails has a response on the switches http://www.monorails.org/tMspages/switch.html - what are they missing?
Yeah, same here. I'm doing the Johns Hopkins Data Science classes on Coursera, as well as the Duke "Statistics with R" series, but I've been supplementing that with both dead-tree books (R in Action among others) and other videos (like the Professor Leonard ones on Youtube), reading Wikipedia articles, etc., etc. Gaining a good understanding definitely involves attacking the problem from multiple angles in my approach. :-)
One big elephant in the room no-one wants to talk much about (according to my Japanese wife) is that, incredibly, health insurance doesn't usually cover childbirth in Japan. They don't consider it to be an "illness" and therefore, you're on your own!
Likewise, having a population of 1-2B also introduces the risk of scaling beyond the food production capabilities of the land. Obviously an overpopulated country can (and likely will) take from an underpopulated country, but modern weapons create a new dynamic if an invading force attempting to occupation farm land or capture grain stores is viewed as mortal threat.
People in this discussion keep on referring to the levitation as "maglev." It is a form of magnetic levitation, but it's significant that they're planning to use Halbach arrays. Musk's original idea was to basically "fly" the pod inside a low-vacuum tube using air bearings on the bottom of the pod. Halbach arrays basically fly above a series of passive metal coils. The faster the Halbach arrays are traveling, the stronger the field, which lifts the pod, which decreases the field, lowering it again. The system experiences negative feedback. It's self regulating. This makes it much cheaper than other forms of Maglev.

The advantage over Musk's original idea, is that Halbach array levitation doesn't require the tight clearances that air bearing levitation would require. Apparently, the cost of manufacturing linear arrays of aluminum coils is cheaper than ensuring tight tolerances.
By being interested in what you are working on.
Interesting. I suppose I haven't been here enough to see it.
Even with the best of intentions things can go wrong and there are lots of unanswered questions in this emerging field. I'm sure the medical organizations involved are very aware of these problems, like protecting the privacy of those in the datasets. We've seen medical data de-anonymised in the past - it's not a trivial problem to solve. Likewise there are moral issues. What happens if you discover X% of people in the study have an extremely high risk of developing Parkinson's? Do you contact them? Do they have the right to know? Do you have the right to tell them? Would they even want to know? These are questions we're only starting to think about now.
You still have to want to have children. Children are a hassle, even after they're out of the womb.
This is really not surprising. Media coverage of 23andMe all the way back to its founding has said that it was offering SNP testing at-cost to build a big database which can be used for all sorts of things (although they were probably too optimistic about the usefulness of it). The real scandal is how 23andMe has published appallingly little research based on it. When I signed up with 23andMe, I was totally fine with them selling my genetic data; because I expected them to be participating in research. Instead, what we get is occasional cutesy stuff, occasional contribution of a cohort to other researchers, and a few papers a year on not particularly interesting topics like coffee consumption (some hits, naturally, since everything is heritable, but not an important topic). Contrast this to the UK Biobank which has been - with a fraction of the 23andMe sample size - releasing blockbuster paper after blockbuster paper over the past year alone!
I-- it... what??

I really haven't been paying attention O_O
I don't think any of Windows 10 window managers is swappable so anything you will run on top will mean significant friction and loss of usability.

I think Cygwin is already using Pacman so perhaps you can get it to work without root on Ubuntu and hence on Windows 10.
These blog posts are designed to generate clicks sadly.
Nobody is forcing anyone to use 23andme. If this bothers you don't use this service?
When I signed up for 23andMe at least half of my motive was to help them discover new things about people's genomes including the development of new drugs. So good for them, basically.
Probably unlikely. There was that thread::scoped issue last year right before 1.0 where some incorrect assumptions lead to an unsafe API that was thought safe. But it was unlikely to happen to app code and be exploitable.

I examined every MS security bulletin over a 2 year period. Nearly all the serious ones were regular C/C++ code memory corruption issues. From what I could tell, Rust would have prevented every one.

MS's .NET had a few serious bugs. They were basically all class loader logic bugs (XBAPs getting more permissions, ways to bypass the CAS system). It's similar to the Java plugin issues: Java applets themselves were never exploitable. But the plugin might accidentally let you do things you're not supposed to. The most user-impacting was stuff in ASP.NET, which is more like an app framework, not a runtime. (There were some "load up arbitrary code/read arbitrary file" bugs IIRC, caused by bad crypto and logic.)

I actually found probably the first memory safety CLR bug[1]. If you loaded a function pointer of an un-jitted function, you could end up with a safe/verified pointer (delegate) to unmanaged code. So there's a true issue, where the implementation is letting you escape and do unsafe things while saying it's verified. But, there's basically no way for this to turn into an app-level security issue. The only use was to escape the .NET code-level sandboxing (CAS).

1: Well to my knowledge -- none were published before. But neither was this one so who knows how many there actually were.
Yes 1000x. Marketing & sales are way harder than coding and I feel it is not focused on enough in discussions about starting a business.
23andme doesn't provide this data. I'm assuming you exported your data to a 3rd party service. Could you share which one?
Daniel Kahneman’s Strategy for How Your Firm Can Think Smarter
If you ever happen to bork your kernel badly enough to prevent it from booting, you'll find a classic VI pretty quickly, and probably be grateful for it.
Ha, I wonder what the students in that class thought when the instructors were "too dumb" to teach the consensus understanding in corporate finance.

That said, on Hacker News, subjects like company valuations seem to be discussed in terms that are more consistent with economics than what you typically hear from students of finance.
Anonymization of data is not a simple task. Even with the noblest of intentions things can go wrong. See the problems with the sharing of medical data in the UK and examples from the US [1].

[1] http://arstechnica.com/tech-policy/2009/09/your-secrets-live...
I wonder how Microsoft managed to implement the Linux ABI all of sudden, while Wine has been developed for more than 20 years and yet it's still very hard to run most modern Windows software using it.

Note this isn't a rant by any way, I appreciate the work done by the Wine project a lot and use it every now and then. I'm just trying to understand if it's a matter of manpower, simpler task, or better design.
+1
from a 23andme customer who still thinks this was a questionable "funvestment"
Ok here's an obvious list of things that should be useful. Obviously you agree (as I do) with the Leo Babuta concept of 'habits' versus 'discipline' [0]. I'd say these are just the basis - but I believe all of them will help if you can apply them consistently. But I'd also say that there's not much point in trying other techniques until you feel you've consistently tried these for a year or more (potentially I'd say up to a life time of trying).

1. Headspace (daily meditation) [1] - helps with focus

2. Wait But Why on procrastination [2]

3. 4 Ways to get motivated [3] - I like the second one about a 'pre-game routine' doing the same physical activity just before starting work. I do the yoga 'sun salutation' twice (takes about 5 minutes, helps with back problems)

4. Leo Babuta's free 'Focus' book [4]

[0]: http://zenhabits.net/discipline/
[1]: https://headspace.com
[2]: http://waitbutwhy.com/2013/10/why-procrastinators-procrastinate.html
[3]: http://plan.io/blog/post/146892730063/4-ways-to-get-motivated-when-you-dont-feel-like
[4]: http://focusmanifesto.com/
They're not exactly relevant examples because they were introduced a dozen years ago when the landscape was completely different. Among those introduced in 2014, I haven't found people who live off their sales. I'd love to know whether there are such recent successes.
Except you're not supposed to clinically interpret those results. That's why they got in trouble from the FDA sometime ago. And now you're putting extra stress on the health care system and opening yourself up to false positives, which may lead to some really bad outcomes.
About two weeks ago, Russian president Putin told they are going to have teleportation by 2035:

http://www.telegraph.co.uk/news/2016/06/22/russia-aims-to-de...

Isn’t teleportation more practical than a Hyperloop? It doesn’t require the land, nor the power to make and sustain the vacuum…
Yea, I'd really like to know why too. Notice the majority of comments on this thread don't do this.
How about a demonstration system spanning the island of Manhattan: https://en.wikipedia.org/wiki/Pneumatic_tube_mail_in_New_Yor...

The thing about hyperloop is that none of the technology is new...or even recent! The pneumatic mail system in NYC was in use between 1897 and 1953. What's new is that in the 1950s the energy economics made it cheaper to replace pneumatic tubes with automobiles. Fast forward 60 years and the energy economy has been turned on its head, thus hyperloop.
Anything where I have a well-defined thing that I want, but I don't have the talent or expertise to do it myself. For me that's design work, but for you it could be setting up a database, creating a kernel module, etc. I view outsourcing as a way to save money in the long term, but good outsourcing should cost a lot up front. If you're looking to save money right now by outsourcing, you are probably going to get what you pay for.
k of course. Having said that, experienced vi/vim users rarely use jk to get around. Instead we use { } / f etc.
They used to
'But that's not how how genotypes and phenotypes work for recessive alleles.'

Recessive alleles aren't immune to natural selection. It's just harder to purge them because they get exposed as phenotypes less often. As they become rarer and rarer (it'll manifest as a phenotype as the square of its frequency), selection weakens. Homosexuality, however, is common enough and the fitness penalty large enough that any recessives are exposed to a lot of selection, so it should be disappearing fast, but it isn't, which raises a lot of questions of what exactly causes homosexuality.
23andme does provide health data in other countries like Canada.
If you signed up for 23andMe when it was considered a medical testing lab rather than a medical device you can get a lot of extra information. I've heard you can use Genotation[1] to get something similar but I'm not sure how good a job they do on explaining things or telling you which parts come from multiple large studies and which are more speculative.

http://genotation.stanford.edu/#start
I think the grandparent is oversimplifying a bit. Even that group that is really xenophobic has people groups different then themselves which they are comfortable associating with, I think the unifying factor is everyone has some group of people they stereotype, or in more lyrical terms, everyone is a little bit racist, sometimes.
The question I guess is not what diseases are in decline, but which ones are going up
We do, but that is from your perspective, and your perspective is from a bubble. The US is weird: We have a huge group, the majority even, who are not very xenophobic, and this makes us unable to recognize that that kind of xenophobia is the usual state of affairs most everywhere else in the world - Including most of europe, even the top-tier liberal parts like France. The xenophobia differs, but if you go out of the major cities you'll find very little actual integration of immigrants, only enclaves and ghettos and occasionally whole towns, with a separate culture and values.

Only the US has had major success integrating on a national scale. There are parts of England, major cities in France and Germany are pretty good, but the countryside is still divided. And much of the countryside is still divided in the US, too, it's just that there is a visible contrast for us to speak out against.
The 23andMe data is amazingly useful for academic research too. I am familiar with a study (but not involved), soon to be published, that used their data to identify genetic variants responsible for a particular problem with pregnancy. The price was phenomenally lower than a more typical genome wide association study (GWAS) of which there are several publicly funded efforts. The results are much cleaner than previous studies simply due to the large number of individuals involved. The privacy controls are very stringent too.
Insurance companies finding your dna and charging you more based on it?
The Monorail Switch Myth
Ans: Diabetes
I think it is basically just complexity. I have been thinking of selling Windows to a non profit foundation for a while now.
Can access to Windows source code help?
> I was able to print out a 3 page report to give to my
> new doctor that described what medications I had a
> low / high tolerance for and what medical conditions
> to look out for as I grow older

Respectfully, I've previously paid a reasonable amount of money for things that have given me medical-looking reports back[0], but later turned out to be largely fiction.

What gives you confidence in this report?

[0] Turns out food intolerance tests aren't actual allergy tests. Who knew?
Well this is 9 days old so I doubt you or anyone will see it. But I really want to say that this is just how language evolves. Phrases appear, become common, and even change meaning, subtly or entirely, from the original.

I don't think it's a waste of space. I think it conveys some information. If you remove it from a paragraph, the paragraph feels different. The meaning slightly changes. In a literal sense it may not mean anything, but I feel it does convey some intention from the speaker.
I'm impressed by the website's anti-ad-blocking technique; they hide the photos but show the text. I don't know about you all but, I responded readily by opening in an incognito window (where my ad-blocking is not enabled). And then I am rewarded as there are just two mellow banner ads all the way at the bottom. Why don't more websites use this simple technique?
Just look at your keyboard :-)

(https://en.m.wikipedia.org/wiki/ADM-3A#Legacy)

I always try to remember them by noting that the leftmost key moves left, the rightmost key moves right (not too hard), and that 'K climbs' (using alliteration to remember that). That leaves 'J' for cursor down.

In practice, though, I use the cursor keys. Luckily, they work on the editors/systems I work on nowadays. Side effect is that I am very bad at remembering those mnemonics.
> Do you have the right to tell them?

This I don't understand: what does it mean? What is the right to warn people of dangers? How do you earn such a right? How do you lose it?

Have someone else tell them if you think you haven't the right somehow.
I think many of the code could probably be directly reused.
The Linux syscall ABI is pretty small and stable, and once you have that any userland program just works. Windows (NT) doesn't have a stable syscall ABI, instead having stable ABIs for libraries that wrap it in various ways (Win32, most prominently, but historically also a POSIX library).

As such, WINE has to reimplement all those libraries, whereas Windows only has to implement something comparatively tiny.

I expect someone can write a better summary of pros/cons of both approaches (and there are definitely both for both!), so I'll leave that to them!
I have family that lives in Japan for 15+ years and, while being a nice country with good quality of life, they say foreigners can never expect to be fully acknowledged citizens (e.g. how difficult it's to get citizenship, requirement of Japanese ascend, etc). It seems very closed to foreigners.

Maybe that's different in the tech world.
Yes, but you can agree that Shenzhen is a little different from a station at the endpoint of a hyperloop. To have a city grow more or less organically it's going to take a lot of time.

It makes more economical sense to build a hyperloop between cities that already exist and can sustain it, than to think the world works like Transport Tycoon Deluxe.
I just want to pay for a service or product and have that be the end of my interaction with the company as well as the end of the company's use, possession, and monetization of my data. When I buy a stick of gum I deprive the store of that stick of gum in exchange for money. On the Internet I'm purchasing something but the company gets to hold on to and share it indefinitely. It not only benefits from the money exchange but also continues to use the very product they sold me to continue to beef up their profit. Taking my money is apparently just a nice bonus but not what they're really after. I wish the privacy cost was stated in as clear terms at transaction time as the monetary cost, and I believe that users should receive royalties when their data is used for any continued access.
I know k is up, because I constantly <ESC> k in bash, bit the point of using hjkl is exactly not to know which one is what. You set your finger on the keyboard in home position, now your muscle memory does the rest.
Cities are like organisms, and as such, they only grow in the right "habitat" where conditions are right. Namely sites that are intrinsically important in some way, where there are numerous reasons for a city to be there. Proximity to transportation infrastructure is certainly one of the factors, but if that's all you have, lacking will be any of the others you'd find in a great city (most of which tend to be by-products of its having been there a long time, which usually means, maybe ironically, being near the transportation infrastructure we tend to associate with past centuries i.e. rivers, harbors).

Result: You can't create a truly vibrant city in an arbitrary location. You might be able to manage a bedroom community or suburb though.

An example like Shenzhen from a centrally-planned economy would tend to have limited applicability to the US, but this one is interesting because it's the exception that proves the rule. Shenzhen would've been an "important" place regardless, due to its being the first place in "mainland" China north of Hong Kong. Before 1980, the aforementioned central planning kept it from developing as fast as it probably would have otherwise. When they opened it for foreign investment, it took off like releasing a slingshot, hence the high growth rate.
A privacy policy is not informed consent. Nobody would have a problem if they asked first. The tech industry likes to act as if they have a right to use any data they get their hands on for any purpose; why wouldn't you expect a hostile reaction when people see their data being used without their explicit permission?

A common response is that nobody would participate with a proper opt-in system. That lack of participation is sending a clear message.
I think it may just be taking time for scientists to start working with their pipeline, which is somewhat cumbersome simply due to their privacy controls. I predict we will start seeing more studies soon. See my other comment on this thread for details about one of those studies.
Already illegal.