skysight-inc/HackerNews huggingface dataset:
My understanding is that this trial is just

1. adoptive CAR T cell transfer
(which has been shown to work
with varying degrees of success)
2. PD-1 is CRISPR'd out (to combat exhaustion)
3. The TCR is CRISPR'd out (to increase specificity)

CAR Ts have certainly had some success; my concern with this trial would be more autoimmune problems, not that it would fail hard.

Is there something else about this trial that would make it unsuccessful?
Well this is about Boston which has a fair bit of SV style tech but also lots of biotech, pharma, finance, GE is moving their hq there etc.
It's only prejudice if it's not based on direct experience. Many of us would rather avoid going back to Windows at all.
There's a much simpler solution: early exercise. It's already possible and good companies offer it as an option. You exercise all of your options immediately upon joining. The difference between the fair market value and strike price is zero, so there's no tax due upon exercise. If you stay for at least a year, which is where the cliff is, you're now in long-term capital gains territory. And if you leave before all of your options have officially vested, the company is entitled to buy the shares back.

Now, let's address the problem in the article of employees not having enough cash to even exercise their options. If the company is truly concerned about this, then they can provide a signing bonus with which to exercise the options, plus a bit more to cover the taxes on that additional payment. Since the cash goes straight to purchase shares, which goes back into the company's bank account, it's a net zero on the books. The only expense here is the taxes.

Please, explain to me why this won't work. I'm genuinely curious.
So on the one hand they talk about a growing, thriving, city, and on the other, they're talking about retirees shutting themselves up in their apartments? I would think a retiree would prefer the calm and silence of being nowhere near a city.
You don't have to be old to get diseases. The way I see it a few aches and pains are a small price to pay for not being dead.
does anyone have opinions on how this stacks up against h2o?
Show HN: Tinder-like app with Facebook messenger platform
Well, the goal is to dangle the carrot in front of you but make sure you can't ever actually take a bite of it.
In Boston, its international students due to high density of colleges.

Seaport is hot because it's becoming gentrified and GE is moving in.
How GraphQL Changed How Artsy Writes Native Code
Um the calais jungle? Molenbeek in Belgium, Rosengard in Sweden.

https://www.youtube.com/watch?v=jSbgxChQAhQ
The original UTF-16 can only represent 65536 code points, what is less than half the number of unicode codes today. It was broken at the expansion around a decade ago.

There's a new, incompatible ("mostly compatible" may explain it better) UTF-16 encoding that represent all unicode codes, but well two formats with the same name is even more broken than only a broken one.

UTF-32 will suffer the same fate as UTF-16 if unicode expands. And UTF-8 is capable of representing an absolutely huge number of codes, requiring only non-breaking extensions.
I think folks might be misinterpreting this a bit -- his issue with the 10-year window isn't that it will 'prevent' shares coming back into the pool (remember, the article started out talking about how employees should be able to exercise their options regardless of their cash constraints), but that giving folks the ability to wait-and-see for years, with zero risk, before pulling the trigger isn't really fair.

Let's say you are working at a start-up, and it's going well. You leave. You exercise and spend the money for your shares in your 90 day window. Great.

Now, same thing, you have a 10-year exercise window. You don't exercise because:

1. Why spend the cash?

2. Waiting will de-risk the thing.

Now the company starts struggling. You're holding 'dead' options, the company needs to recruit and expand the pool, and you get to watch from the sidelines. You may never exercise and in the mean time the pool has been refreshed unnecessarily. That's the issue. By forcing a decision, the company has a clear picture of its options pool, and employees have to make a decision based on reasonably present information.

The cash requirement of buying options sucks and I'm not sure what to do about it (if you earned it, you should be able to get it), but I agree that a 10-year window isn't the right solution either.
I came to this thread dreading some sort of bizarre political firefight but instead I actually learned something fairly interesting.
Elixir and F# have my favorite syntax for that:

values |> map(&({})) |> flatten |> compact |> uniq

Although, the closure syntax is a little clunky before you get used to it.
> I hear you on this. I'm currently working on a writeup about the history of open source and the GPL.

If you're going to write up a history, please use the term "free software". "Open source" didn't exist for a large part of the history of the free software movement (and I would argue that it was a movement to sabotage discussions about freedom).

> The dream of having totally free and open replacements for major tools like Photoshop never really happened. There is a lot of new OSS, but it's all BSDL, Apache, MIT and other license.

It did though. Okay, Photoshop is still not overtaken by GIMP. But we have professional free software video editors, development tools, web and database servers, document writers, etc. These days you can run a modern system entirely in freedom, though of course we would love to make more free software to do things even better.

> I'm not like a hard core Stallman person. I don't run libre-firmware laptops from pre-2008 and I enjoy my Gapps on my phone, but I'm not a big fan of startups/monetization of everything. I think a lot of good ideas are strangled by making them commercially viable.

I'm slowly becoming one, and the main reason why is because I want to work towards the world I want to live in. Sure, lax licensed software is fine to use as a free software advocate. But when I develop free software under a lax license, I'm acting against the free software world I want to live in. By allowing proprietary versions of my software to exist, I am acting against my goals.

I want to live in a world where all of the software I need to use is free. All of the hardware that runs updatable software also must be free. Otherwise, I'm powerless when the developers' company decides to do something immoral. Having code under the GPLv3 protects us from both of these things, and it makes me sad when people use lax licenses for innovative work.
There doesn't seem to be any elegant solutions for equity compensation yet. The main issues seem to arise once an employee leaves or gets fired. While the employee did put in many years of work, its not too fair to have the options disappear after 90 days. At the same time, as mentioned in the article its not 100% fair for the employee to keep the unexercised options for a long period of time.

A solution a few people have discuss would be to allow the unexercised options to remain under the employees name, but the company would be able to re-issue the options to new employees at a higher strike price. When the new employee exercises the option (assuming the value has risen), the company would get the strike price of the initial unexercised option and the former employee would get the difference between the higher strike price and the original lower strike price.

For example:

Employee A is granted options with a $1.00 strike price.

Employee A leaves the company after a few years but doesn't exercise the options

The company re-issues the option grant at $3.00 to Employee B

Employee B decides to exercise and pays the company the strike price.

The company would keep $1.00 and Employee A would receive $2.00

This seems fairer than the current structure and allows Employee A to still benefit from the options if the company continues to do well without him. Of course, implementation would be much harder/complex.
Am I the only one who saw the twin towers?

Sorry, 9/11 still has me on edge.
It's difficult at this point to come up with an example, since we don't have it yet (that I know of), but to give you an idea, take a look at Lively Kernel https://www.lively-kernel.org/

If you want a demo, you can take a look here:

https://youtu.be/QTJRwKOFddc
The name might be worth something. Everyone knows Watson due to the Jeopardy stuff. "New from IBM and Amazon, Watson in your home!"*

*It's just Alexa with a male voice and some tweaks from IBM.
From my perspective in the UK, it's been interesting (though frustrating) to watch what's been happening.

It definitely seems like political discourse has taken a turn for the worse. In contrast with the Scottish independence referendum a couple of years ago which, although there was some animosity, did feel like a genuine political conversation… this one has seemed much more like an angry shouting match.

I'm particularly interested in the comparison with Trump in the US. In both cases, it feels like a nominally populist, anti-bureaucratic/anti-establishment movement (the extent of the truth in that being debatable) has been able to make a substantial impact with that platform, due in part to the abject inability of that establishment to deal with and neutralise the movement.
Will Angular 2 Take Off?
In Boston & Cambridge there are quite a lot of tech people making $200k, even as individual contributors. And there are many two-job couples with household income over $300k.

A million dollar mortgage will cost $6000 per month, which is only 36% of $200k or 25% of $300k.

So yes, plenty of people can afford it.

> assuming this guy paid cash

There's no reason to assume that, although there _are_ a surprising amount of cash buyers around here.
It's a well known phenomenon called the "UNIX beard" [0]

[0] "The length, bushiness, and unkemptness of the Unix beard are all directly proportional to the owner's expertise." Source: urban dictionary
Hard to imagine this merits downvotes...happy to be corrected though.
Hipsterbabble.
> We invented the 90 day free ssl.

Utter jackassery. I'm adding Comodo to my semi-permanent "never-do-business-with" list along with GoDaddy and Best Buy.
Sorry, you're absolutely right. I should say 'many', not 'most', my comment was hasty. It varies with the therapy and only a minority of patients fail because of adverse immune events, and the drug matters - ipilimumab (anti-CLTA4) had 10-15% severe immune-related adverse events, whereas anti-PD1 is much better tolerated (probably because the immune checkpoint is later). Combination therapies (ipi + nivo) have much higher adverse event rates, unsurprisingly.
The cost of the options is too high. Take a company valued at 90m pre-money for their Series B (a $10m investment). Their post-money valuation is $100m. Now assume the common is valued at 5x less than preferred. If the company wanted to do this and their hiring plan has them hiring 20 employees for a total of 5% of their options pool in options they now need to set aside $1m of their financing (5% * 20m) just to finance purchasing the options. That's unlikely to happen.
It's right underneath the 'Domain names' box, in to USD / GBP / EUR based on country (which is in turn based on your IP location).
>rewrite the blueprints of life itself

Something unsettling about how that is worded, but this awesome. There hasn't really been any major breakthrough like this in a very long time, as the era of antibiotics ends, new treatments like this might open the door for a new wave of medical treatments.
Management should not do this because it makes it harder to hire at all stages of the company until it's liquid. And founders know how fucking hard it's to hire in general. If you fuck over early employees, what prevents you from fucking over later employees?

And imagine trying to do something equivalent to investors. How easy will it be to get funding then?

If I'm an early employee trying to join, will you fuck me over or will you give me liquidity? I will look at your options program, if I can early exercise, if you will give me hell for using ESO fund.

Now the internet is starting to write how being an early startup employee is an extra bad idea. The very public example of zach holman and other articles creates chilling effects on startup hiring.

It's what made me choose to go to the big company after my last job.
Why it is hard to hire women in technology
Why obsessed hockey fans are updating ‘NHL 2004’ every year
We were the first startup to use 10 year exercise periods, which started this trend. I wrote a long response to this here:
https://dangelo.quora.com/10-Year-Exercise-Periods-Make-Sens...
So my joke below gets downvoted to oblivion and yet this trash is still here. Why?
I'd just like to know in English why my comments sucked, down voting or not.
Calendars!

When working in finance, you care a lot about public holidays, because interest on wholesale loans between banks is calculated per business day. On global scale, there are more public holiday schemes than countries or timezones. And some countries change their public holidays willy-nilly on short notice.
Is linking to some random opinion article on the Internet your way of arguing for the validity of stereotypes? Well, I'm convinced. Too bad "accurate enough" doesn't work in physics, we'd already understand the universe by now!
Weird, this link is giving me infinite redirects. I went and found it on the stackexchange site myself under hot for graphicdesign and it did the same thing. The other answers on that subdomain work just fine. Strange.
That's the plan for our son who will be going in a couple years. He doesn't know what he wants to do, so why pay much more (not that its super cheap, but cheaper than many other options). I myself transferred schools multiple times - the greatest thing is the credits transfer, but the gpa does not, so if you screw up a few classes in the beginning, you can reset that.

In the end people really only look what you list on your resume - not the first x years, but where you graduated from and how well you did at the end.
Because that way you can't truly fuck them over. If you don't give a baby some candy, it won't cry, for it has no need to. You have to first give it the candy, and then take it away, for it to feel really bad.
Twilio is an obvious mention. More expensive than Pilvo (I never heard of them and only need SMS for a project of mine so thanks) but I've never had an issue. Twilio also supports carrier lookups, you might be able to leverage that and send emails to '@mms.att.net' and the like.
They would throttle all encrypted VPN/torrent traffic that's not HTTPS, so then VPNs/torrents would pretend to be HTTPS and then... I don't know, but it probably won't be good.
I'm looking forward to seeing what the web does with the presidential election. The last election I remember paying attention to was Obama's win in 2008, and that was basically just telecast on TV.
It would be good to know which of them support international numbers, or how many country it covers
There was an opportunity to fix the insanity in an earlier referendum. Such a wasted opportunity.

Probably the saddest referendum result in my lifetime https://en.wikipedia.org/wiki/United_Kingdom_Alternative_Vot...
You underestimate the value attributed to PR by large corporations.
That this sort of thing is necessary is crazy. I couldn't live without my automatic refactoring tools in other languages.
If you're raised in a suburban middle/upper middle environment you're told to go to college from day one by parents, teachers, friends, etc (especially parents). In some families there's actually little choice, but even if the student had the choice, it's a hard one to make in such a culture especially at age 17/18. That said, community college -> college is a safe and affordable option.

The opposite happens too—I know a lot of working class kids who didn't bother with even applying to college because it was unheard of in their communities. They went straight to work in trades and such.

PS: Petroleum Engineering is seasonal and not that good of a career choice as it depends too much on oil prices. I lived in Houston, an oil city. Many of my peers who did Petroleum Eng are out of work or with way lower salaries than advertised. Also, if you go to a state school you can graduate with little or no debt!
EU Referendum: Brexit Vote Results Live
Show HN: Bestow – flexible, multi-model labelling gem for Rails
Ok, this one had me really wondering.

From the piece: "Fundamentally, we are here because companies are choosing to stay private significantly longer than the time period for which the four-year option vesting program was originally invented. It’s a historical anachronism from the days when companies actually went public around four years from founding. Today, however, the median time-to-IPO for venture-backed companies is closer to 10 years."

This is just plain wrong. We are here because Congress decided to close "loopholes" in the Tax code associated with stock options.

Before they did this, you could exercise your option, at the strike price, and if you did nothing else you owed no tax. It was only when you sold the stock you held, were any gains or losses computed, and the taxation was based entirely on how long you held that stock (long term or short term).

Now the reason they did this, was that giving someone stock options in a publicly traded company is very much like paying them cash. And so the IRS wanted to "capture" from those people income tax they would otherwise avoid. And you could see it if someone paid you $1, and gave you an option for 1000 shares with a strike price of .001 but a current trading value of $50. You paid income tax on $1, used that to exercise your 1000 shares, and a year later you sold them for $50,000 paying only long term capital gains. Clearly avoiding the income taxes on $50,000 they really "paid" you.

They closed this loophole with "alternative minimum tax" and which basically a rule where if someone gives you a lottery ticket you have to "pretend in some alternate universe" that you won the lottery and actually pay the taxes you would have paid if you had, and only when its clear that you couldn't possibly have won the lottery can you treat that as a tax "loss", but they don't give you that money back, rather they let you write it off slowly over years and years and years. And as you can probably tell I've written a number of angry letters to my congresscritter about it, especially in the context of an illiquid asset like pre-IPO startup stock.

Without all the tax shenanigans options would work just fine. When you left the company you'd exercise them, owe no tax, and hold them for later. If you happened to be in a universe where "later" they were tradable, or you figured out a way to trade them non-publicly, only then would you have to pay taxes on the gain.

The trick is getting tax law changed to exclude artificially valued shares (which all non market traded securities are) from the AMT and income calculations.
My guess: it's not adding much to the conversation. HN tends to frown on humor that isn't intellectually and conversationally productive.
Based on just a brief reading of the article, I see it more like an equivalent of Keras/Lasagne for Torch, but I might be wrong.
From what I saw, it'll be morning before the vote is certified. It looks like only 9 of 380ish voting districts/constituencies/etc. (sorry, I'm not British and don't know what they actually call them).
The social dilemma of autonomous vehicles
I'm getting the same thing.
I'm getting the same thing (in multiple browsers).
Chris, been a huge fan of Elixir and Phoenix. Do you have any scope on the performance of Elixir versus standard erlang? I am gathering the opinion that erlangers believe Elixir to be slower in general? E.g. the performance of poison versus jiffy
The Guardian has an interesting map, where the size of each County is proportional to the population: http://www.theguardian.com/politics/ng-interactive/2016/jun/...

It gives a different perspective to the early votes coming in...
The fun thing is that I don't think the Windows console can handle anything outside BMP.
Hipparchus 1.0 released
That's a 58 page legal ruling. It sure would benefit from some legal eagle summarizing it. I didn't read the whole document, and even if I did I wouldn't necessarily understand all of it.

Apparently it involves someone's use of a Tor website called Playpen, which hosted a good deal of child pornography.

One really really disturbing thing to me is that the Feds raided a house in Florida and seized control of the site, and then:

The FBI did not immediately shut Playpen down; instead, it assumed control of Playpen, continuing to operate it from a government facility
...
Defendant argues a substantial increase in the usage of Playpen occurred after the Government took it over. While the Government concedes that there was some increase, it disputes the unsupported figures in Defendant's briefs.

That just seems so wrong. The Feds seized the website and then continued to serve child pornography from it for at least several weeks.
I'm afraid I don't follow your math. The cash to exercise the options goes immediately back into the company's bank account. It's as if they were handing out shares instead of options. The only expense should be the tax on the fair market value of the shares, which should be considerably less than 100% of their value, no?
I've encountered engineers throughout my career that have been against all of it.
Can you already use let's encrypt with cloudflare? (HN uses it for protection)
Phoenix looks great, but seems like it's focus is on serving html to websites (like Rails). Is there something simpler for building REST apis for mobile/single-page apps (like Sinatra)?
I'm a big fan of reforming the electoral system in the UK, but the AV referendum was an awful fudge at best, plainly just offered as a sop to the Liberal Democrats.

It was genuinely one of the worst referendum campaigns of all time though. I'm still haunted by the 'if you vote for this then babies will die' adverts.
One of the things I dislike about graphics displaying live (or otherwise unfinalized) electoral results is that the viewer must know something about political geography in order to interpret them: Are the tallies I'm seeing in line with how those districts were supposed to vote? Is it just happenstance that the votes counted so far have come in disproportionately from districts expected to vote against the expected overall result?

Please, if you work on these things, try to help us understand what we're really seeing. Otherwise, your work is for naught, because we will all learn to say, "Bah, I'll check the results in the morning."

Do any of you have ideas about how better to display live results? Maybe a heat map showing the difference in the actual results versus the polled expected results?
The answer to your question is yes, that's the way it worked, but I didn't do it intentionally. My next company just happened to call right around then.
Has Something Gone Terribly Wrong on LinkedIn?
Oh I see, perhaps I was wrong on that. A freind of mine in the UK said this. Must've got that wrong.
So we are on the brink of trade wars. If the UK leaves the EU it will start a trade war with the Continent. Meanwhile, if Trump gets elected he'll spur a trade war with Mexico and China. Interesting what that will lead to. Loss of jobs, for one. But what else?
"Not a total pussy" because you're willing to gentrify a formerly working-class, affordable area to get yourself on the property ladder.

I mean, I'm all in favor of new building. New building everywhere! For everyone! Yay! But calling someone a "pussy" because they'd rather not be taking formerly affordable rental housing off the market is pretty nasty.
You'd be surprised. There are definitely building and appearance rules in the nicer old industrial area. Nothing like other places of course.
Do you think taxes like this will go away at some point? or will it always be there in some form?
Apple Discontinues Thunderbolt Display