skysight-inc/HackerNews huggingface dataset:
I think you should be conflicted for a slightly different reason :-)

Should Americans pay for a disproportionate share of pharma revenue? I for one am so happy for all the medical research that we fund in this country, it is probably the best thing we can possibly do for the world. Of all the American foreign aid and foreign intervention, very little else will compare to the amazing impact of widespread access to Harvoni/Sovaldi in India. That is truly an amazing gift that America is giving to India, and it's made possible exactly by extreme price discrimination.

This is an amazing miracle cure for a deadly disease. My understanding is that it cost a lot of money to develop, and took a lot highly skilled work, and involved a fair measure of risk of total loss. We want wins like this to be rewarded. We want a significant fraction of the dollars this drug earns to ultimately be re-invested in more of this kind of R&D. We definitely want more drugs like Harvoni/Solvaldi coming to market.

So the conflict I have is, when manufacturing is not the bottleneck, you want to get this cure out to people everywhere, but at the same time you can't afford to pay for it all to happen in one year. So you see cases like OP where they won't pay for the treatment until you are showing symptoms. But the cure is so easy, nobody wants to wait for symptoms, and how can you blame them?
Yeah. There have been spontaneous demonstrations of joy and gratitude for our happy new way of life. Said no-one who's job just got automated. Automating work out of existence may or may not be a laudable goal. Assuming it is we've yet to see a roadmap presented that doesn't brick the economy somewhere in the middle of the gap between now and full automation.
Show HN: Simple and useful .gitignore file for Perl, PHP, or ColdFusion
One of the great benefits of a console interface is that it's a lowest common denominator between different OS. That interface is based on a byte-level I/O model. Things like I/O redirection depend on it.
Simply unconscionable. I found out about this recently and many people I've ranted to about it seem to think it's just one of the costs of being a criminal.

I guess we've just gotten so "tough on crime" that we've forgotten that many people in jail are there without having been convicted. Moreover, I don't think a lot of people realize that the only reason many of those people are in prison at all is just because they can't afford bail to get out before their trial date.
As someone who was following the market when Gilead paid $11 billion for PharmAsset, it was not a sure thing that it would be first to market or a premier drug.

This is a fantastic point. I remember when Gilead announced their acquisition of Pharmasset. They were ridiculed in the press. How could they be so stupid to pay that much? Many people thought that $11B was as good as gone.

That's the risk involved with drug development. It's like VCs, you spend a ton of money on a lot of investments, most of which fail. Unless you get a few huge winners, it's not a feasible business.
He clearly doesn't believe in his positions but is saying what he thinks people want to hear. His faux pas on punishing women who have abortions makes that crystal clear. It's what pro-choice people think pro-life people say. Pro-life people don't actually think that way.

I suspect it's the same deal with globalization policy. This is a man who manufactures his clothing outside of the U.S. If he cared about American workers or inhumane conditions, he'd at least do it kicking and screaming instead of acting like he's inculpable.
Does anyone know the prevalence of the most common side effects for Harvoni?

I usually defer to the following site but they don't have info on the drug -- http://www.healthbee.co/
Strange that their job was not to code but to do journalistic duties as journalists.
Well, even for gasses, your results are accurate enough as long as the Mach number is below 0.3: http://encyclopedia2.thefreedictionary.com/incompressible+fl...
> put the map in overhead view, north up ... you build up a geospatial awareness

Totally agree.

I think the other thing that helps in an unfamiliar area is to pre-scout the route.. basically just look at the map around where you're going, while you're stopped. Honestly I don't always do this, but I should and it usually helps.

> can usually tell when the GPS is getting stupid.

The key to this is how you respond.

I used to just decide to go the way I think makes more sense, then often find out there was a reason: a one-way or closed street, no left-hand turns intersection, only one on-ramp to the highway (in the opposite direction I'm trying to go), construction, etc, and then I'd have to loop around.

Now I just become more vigilant. I always pay attention to the road names (and not just "take next left"), but I also really keep an eye out for extra signage (like signs showing the route to get to a highway) or closures.

One of the problems with current GPS tech and the maps is they're really damn good -- but still not perfect. The fact they work so well most of the time makes people complacent.
Is the rise of more efficient competitors overseas the main thing that's made these labs disappear, or has something else more internal to these companies or to the domestic economy changed over the last 30 years?
I would be thrilled if my more mundane jobs got automated and I was paid a stipend so I could focus on something else.

In fact that's what we do as developers. Automate things.
Could you elaborate a bit? I'm not particularly proud of the current config system, but I'm guessing what gave you trouble is more that handling fonts with Qt is an exercise in sanity... ;)
Cool, thanks for making me consider it. It hadn't even occurred to me.
You can, however, give a body-cavity search to a prisoner after visitation.

Plus, from my perspective, the first priority of any prison should be rehabilitation and reintegration of the prisoner into society.
So what's stopping non profits from installing some hardware and letting the prisoners use Hangouts or whatever?

I don't mean that in a dismissive sense, I mean it very directly. Is it expensive to maintain the hardware? Are the companies charging the high rates getting exclusive contracts? Do the communications have to be monitored by the provider?
Right, if something were truly incompressible, the speed of sound through it would be infinite and you could propagate signals through it faster than allowed by relativity.
Have you looked at the screenshots? It's graphical, so, no.
I was under the impression most Pharma Companies will give it to you for free if you don't have insurance and can't afford it. Maybe it's different if you have insurance and they won't pay for it.

The article is unfair mentioning Shkreli. He has always offered his drugs for free to anyone that couldn't afford them. It has always been his policy and continues to be so.

I think it was the Insurers and their paid for Politicians that created the stink. To this day I still haven't heard of one person that had to pay the $750.00 a pill but just their co-pay and if they had no insurance they got it for free.

Surprised this drug isn't available for free for those without insurance or is it?
There is no roadmap. It'll all be organic (unfortunately?). Its up to us to put guardrails on to ensure people who are automated out of a job can still find purpose and meaning in their life (UBI or some other method to ensure no one goes without housing, food, clothing, healthcare, etc).

EDIT: If it goes south, I assure you, I'll be one of the first to devote the rest of my life to getting humanity back on track with the distribution of resource and knowledge wealth (not fiat currency "wealth" mind you, cause that isn't going to be worth much compared to raw resources and automation knowledge).
I'd say that a 20% ROI on the price of the development of the drug sounds reasonable. But the 11B was NOT the price of development; that would have been much lower. Assuming it was 1B (typical number thrown about), then a profit of 200M per year seems reasonable. Cost of manufacture of most drugs is negligible. Assuming they sell 100M pills/year, charging $10/pill (of $840/dose) seems quite fair.
Let's say we shut down Silicon Valley and had the government do computer research. You think that would be efficient and effective?

At the end of the day, you need to give smart people a reason to make their lives' work saving lives instead of selling financial products or advertising algorithms. That's not going to happen if going into drug development means topping out at GS-15 in a government lab.
I suspect if Oracle's wins the case ...

1) they will win a lot of money in the near term but it will greatly diminish the popularity of Java/JVM in the long run because most tech companies shudder at the thought of having Oracle be the slumlord of their core program language.

2) there will be a painful transition of FUD and lawsuits but open source languages/libraries will be ultimately become stronger in industry b/c the licenses can easily be extended to API rights. Restrictively or vaguely licensed code will be looked up on with greater suspicion.
Anyone have an opinion about emacs on Windows ? I am forced to work on Windows and have no idea about the setup here.
How do you think Silicon Valley would work if the ROI on their unicorns was limited to 20%?
Installing it where? Doing business in a prison is far from a free market.
The mistake wasn't that particular varint encoding, but that it was variable length. That means you need to perform more complex decoding which is not the tradeoff chosen for Cap N Proto.
I wouldn't say chocolate chess was a thing, per se. Just a one-off promotional idea I think.
Yes, the companies providing the service get exclusive contracts. They also give a portion of the profit to the prison, so of course the prison is going to help them maintain their monopoly. A non-profit can't compete because the companies that DO make a profit have a huge incentive to stop them. They will spend money lobbying lawmakers, prison wardens, etc.
In other words, what if an all-knowing being doesn't really know everything?

Or are you inventing a new Creator who is merely almost omniscient for rhetorical purposes? To what end?
so how does the Japanese raw denim industry compare to US/China?
Cops can ignore Black Lives Matter protesters. They can’t ignore their insurers
This isn't about tech, it's about politics and profit.
Sure. Is that for good reason, or is it bullshit?
So Qaddafi wanted to create a gold backed currency to complete with the French Franc? Tisk tisk, that's how wars start.

https://wikileaks.org/clinton-emails/emailid/12659
Oh goodness, I would, but I would need to talk to my employer. I work for a CDN, so our DDOS experience is very different :)
Something I learned way to late was to use the build in features for learning about functions and variables.

C-h f : find help for functions
C-h v : find help for variables
C-h k : Get help for a key-combination

If you have helm mode installed it's often very easy to find the functions you are looking for.
Makes me think that this article I wrote on my blog several years ago is more pertinent than ever:

http://greenash.net.au/thoughts/2010/08/boycott-gps/

Seriously, folks. Turn off the GPS, and start observing the world around you. And if you really do need route navigation, do it the old-fashioned way: study a map! (Printed or online, doesn't matter).
That will imply Tesla will no longer be using the standard 18650 Cell mass produced around the world, and instead uses a new specific component made for Car Battery / Tesla Energy, Applying your theory it will be larger, uses less metal around the cell etc. I have no idea in cost associated with battery production, but if it was the same as your Soda example, it will likely means the less metal associated with the Battery Cell are significant cost saving.
Reddit thread on other companies Elon Musk owns
What have scientists (I'm not a fan of personifying science itself) discovered about the nature of good and evil?
Blah blah maths is cool.

But as a privacy supporter; fuck this.

Show me how to thwart this.

Menlo park is requiring this sort of thing for all vehicles driving through it, and I am 100% opposed to this.

So aside from doing what Steve Jobs did, how do I say no?

Edit: just had an idea; there is literally no reason I would be required to display my license plate number UNLESS I am pulled over and committing a crime. So fuck every plate scanner system. I don't need to provide you my identity pre-emptivly ever. Fuck you if you think otherwise. Pull me over if I am speeding or driving reckless - then determine who I am. They already do the "determine who I am part" with my ID. Plate scanning go fuck itself.

That's the only right the state should have on the roads.
I also hope I didn't sound too insulting. I know keeping any site up against DDOS is hard!
Where do you draw the line between inflation and hyperinflation?
Indeed. It's not like there is the LA facebook or the NY facebook or the Chicago centinal facebook, etc... This is more like a "Global Times", let alone a "US times".

So anything they might do which appears to be editorialisitc in nature regarding politics would be of concern.
It's much smaller. It's not quite artisinal anymore, but it's not where the mass-produced jeans the world prefers come from. It's where the high-quality $300-a-pair jeans come from.
If you're the type of person who ever takes scenic routes, do yourself a favor and buy a PLB. You can get an ACR ResQLink for $250, they last up to 10 years, and they work nearly everywhere.
Puzzled why your comment was downvoted; it's a prudent question. Unfortunately the standard of public discourse has become so shallow in the U.S. that this type of inhumane atrocity being perpetrated by our government is unlikely to get more than three days in the media spotlight.
I agree with you. There's no inherent reason why education should be getting more and more expensive. With all the technology we have and the large pool of highly educated potential teachers[1] it should actually be getting cheaper or better value for money.

But the explanation I'm giving is that the middle class like to use education as a filter that keeps the poor away from the nice white collar jobs. So they are highly insensitive to price. Meanwhile, all the broken things about education (in terms of actual teaching/learning) go unfixed.

[1] although there is an interesting argument that women who were previously forced to settle on teaching for a career are now going into industry instead (since industry became less sexist) , leading to a drop in teaching quality (especially for things like maths)
>they're free enough to ensure that superior products generally win out.

Doesn't this imply that the customer has enough information to determine which is the superior product? In reality, it's quite easy to dress up an inferior product with lots of marketing, and gain great success in the marketplace. Heck, look at Beats headphones. They're not superior in any way. Yet, by carefully crafting a marketing message, and putting massive amounts of money behind it, they've managed to get a fairly large share of the market.
city could have lost its liability insurance if the chief kept his job

It'll be interesting to see how things like this end up interacting with due process and blacklist sorts of things, once it's better known and been gone over a few times.
http://www.economist.com/news/technology-quarterly/21651925-...

So, the technology exists, more or less. Like all new technology, it takes time to roll out.
> In the United States, there is nothing stopping pharmaceutical companies from charging whatever they think the market will bear.

That is how it should be. The moment government controls prices, it will slow down overall capital investment in invention of new drugs. I think $80k price is perfectly fair given the scenario.

Until Giliad Science invented that medicine the alternative to the medicine was assured death by cancer. Have you ever paid medical bills for cancer ? $80k does sound like a reasonable amount to pay for one's life in a developed country like USA. In India value of life is much less and I am not surprised Indians are willing to pay much less for their life.

Poor Indians are benefiting at the expense of rich Americans. Indian would prefer to die than borrow and buy a $80k medicine.

I think if Americans can save money by offshoring the cheap call centers to India they can also save money by getting their health treatment in India. The thing to remember here however is that if you die in an operation theater in USA your family might get millions in compensation. In India you have to say bad luck and move on. The pills that you buy from India could be nothing but horseshit packaged in wrappers and you can basically do nothing even if you find it out.

US is at the forefront of drug inventions because markets are allowed to function, surely companies are making ton of profits but I suggest you try setting up a company and invent the same drug and sell it for cheaper price. Inventing drugs is like a startup, a giant number of research projects fail, handful of succeed. People remember Facebook and its obscenely rich Zukerberg they don't remember Bozo inventor of JokerBook, a social network for clowns.

It would be good if Americans learn to appreciate what they have rather than complain about everything.
If I were Satoshi, and I thought people were sufficiently close to discovering that, a ridiculous media circus showing me claiming and failing to prove that I am Satoshi might well be a good way to throw people off my trail for a few more years...
How much is your total experience? And what are your skills in mobile application developer?
I'd think it ought to do a bit better if people who've seen the wrong end of the system didn't tend to get disenfranchised.
Google petitioned the Supreme Court to hear its case, joined by allies including Yahoo, HP, Red Hat, and open source advocates, but was rebuffed. Microsoft, EMC, and NetApp urged the high court to let the Federal Circuit ruling stand, and that's what happened.

WHY?? And here I thought Microsoft was coming around. Fuck these assholes (and EMC and NetApp too). What do these people have to gain by letting the ruling stand? It just makes interop harder. And here they are tapping into the Linux API shamelessly[1]. Shame on you fuckers.

[1] http://arstechnica.com/information-technology/2016/04/why-mi...
https://en.wikipedia.org/wiki/Foxconn_suicides
Changed water source from local aquifer to local river. Apparently the data center takes the water and dumps it back into ground. The sourcing change cost more so citizen water prices went up. Guess what Facebook gets, you got it, free water. Not a joke.

It is crazy how much money we just give to profitable companies.
when did drug possession become a benign crime? last i checked, my man called 'Biz' down the street carries a 9 to protect his drugs and ohh yeah 'respect'. at least someone is profiting off these hooligans.
You probably want a Catmull-Rom or similar interpolating (instead of approximating) spline. It's much easier to control animation or other paths when you know it'll precisely go through the points you specify.
Doctors and lawyers are the top paid professions in the United States: it would make sense to automate their jobs sooner rather than later.
That sounds terrific?
Clinton’s wonky policies of fine-grained complexity
With regard to clothing, "fashion" has, unfortunately, trickled down to everyone. One can buy clothing which lasts, or boots which last. You can buy a 400 pair of boots which will take a beating for up to a decade of use, or you can buy a pair for $100 which will last you a season. Lots of people will balk at the 400 boots. Same with clothing. They'll buy the stuff made with short cotton fiber which begins fraying after a couple of washes --or you can buy the long fiber textiles which cost a lot more. Or wool... or white goods or pots and pans... etc.

Anyway, most people have adopted the fashion cycle --something that only wealthy people would import from the fashion capital du jour.
We are talking 20% ROI, year after year, for the duration of the patent (17 years). That's a 22x ROI. Most SV investors would drool themselves into a pool at the thought.
Basic income is okay but it's missing non monetary rewards and education. Basic income needs to be tied to a system where users learn more about their natural behaviors and become incentivized to self improve in the ABSENCE of the government.

This can be done with libertarian paternalism/nudge theory concepts.
I think you're just replying to the parent's curiosity, but the talk about fairness seems to hint at wanting the government to regulate how much profit private citizens are allowed to have. That to me seems scarier than anything they've done.

It does seem like they got a great deal.
Trump may be a raging narcissist, but he has a long history of kindness to strangers. Probably the most famous example is his 1986 rescue of a widow's family farm in Georgia, about to be sold after the husband had killed himself in despair:

http://www.thepoliticalinsider.com/a-66-year-old-widows-farm...

Thirty years later, the daughter appeared at a Trump rally in South Carolins to thank him, probably one factor behind his decisive win in that state.

http://youtu.be/dRoX9BTu8Ew

If you check the web you can find many other such accounts of his acts of generosity.
I don't think this does a great job of building up an intuition of how these curves are derived. Instead, I'd recommend starting with quadratic (and noticing the constraints on the tangents) and then realize how the cubic is built up from that. Like all (later discovered) splines it's a really elegant and simple thing!
that's actually another nice thing about spacemacs. Install the Java layer and read its documentation, and you'll have a decently curated experience with several plugins set up for you. At least, assuming the maintainer of the Java layer is any good. That definitely addressed choice paralysis for me
There's absolutely no reason to buy everything at once other than habit. It's not as though you run out of food and cleaning supplies and washroom items all at the same time.
That seems off by about 1 order of magnitude...
Bind-mounting does give you some options. Still doesn't help if root's hosed.

And it wasn't an option when I'd first come up with this clever scheme.

One of my current challenges with Linux is identifying which information/education of mine is wholly outdated. This will happen to you in time as well....
I'm not making any claims, just presenting alternative approaches to the problem. The apparent paradox of the "problem of evil" in Christianity depends upon a specific interpretation of the nature of God which the Bible itself doesn't always support. A being that is beyond understanding cannot be merely good or evil, because those are human concepts, which humans understand.
I have a private global (excluding USA) medical insurance that covers costs (no in-patient) up to 1M and it costs me $1k/year. I've been hearing about Obamacare for years and always thought "well, it's good that more people will have insurance". But when my colleagues in US told me what their deductibles on a good insurance plan are (thousands of dollars. my deductibles are $375) I was floored.

The whole medical system in US is broken. This morning I had a strange thought... I need to prepare for trips to US the same way I'd prepare for going to a third-world country: by buying a special medical insurance! It's one of the important TODO items when going to certain countries.

Fun fact: I can get a medical insurance that covers US with deductibles in low hundreds of dollars by doubling my not-so-high premium. As an expat. How crazy it is that I can get a better deal on insurance in US than local people?
> The article is unfair mentioning Shkreli. He has always offered his drugs for free to anyone that couldn't afford them.

[citation needed]