skysight-inc/HackerNews huggingface dataset:
So the company that is saving some lives is more reprehensible than the one that is saving no lives? Companies that create life-saving things should be charities, while companies that create things everyone can "survive just fine without" should be richly rewarded. Right? That doesn't seem backwards to you?

It's not like Sovaldi grows on trees, free for the picking, and Gilead came along and fenced-in the trees and now is charging $84,000 for access. It created a cure to what used to be a terminal disease. It should be rewarded in proportion to the value of curing the disease.
App idea: a "city trainer" GPS navigator. You input your destination, but it doesn't give directions. You still try to navigate to the destination using your mental map. The app warns you if you seem to be getting lost.

It probably wouldn't be very popular...
Well, you're probably right that the goal isn't simply to obstruct intelligence agencies. I am guessing that the idea is more than likely to tell them to quit being too demanding and start acting like just another client.

Plus, being involved with the government usually involves all kinds of regulatory nonsense and (sometimes) having their personnel on premises for whatever reason.

In summary it's probably a cost cutting measure to keep legal and engineering teams from getting preoccupied with government nonsense requests, but hey they can spin it as giving a big middle finger to the government so why not.
Minor correction: the total bill for a liver transplant is more like $700-800K, medical alone (not including personal costs such as loss of productivity or wages).
> everyone, bar pacifist peoples who could only survive if isolated, committed atrocities of one kind or another

That doesn't sound right. What makes you say that every family committed atrocities?
I'm not entirely convinced that's unreasonable. Designing a good API is hard. Most interfaces are terrible.

If someone wants to clone wordpress then maybe they should just design their own API. If the Wordpress API is that good then maybe it's worth licensing.
You're doing the math wrong. The suggestion is not a billion dollar profit on 26 billion dollars of costs. Most of the 26 billion dollars is profit. Chopping the cost tremendously would still leave a healthy profit margin.

As to risk, they bought an already-proven drug. That's not the sort of thing that earns massive returns.
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It's alive and well! But in size and scale, it won't compete with US/China just because of the fact that most people don't care about the quality of their jeans. Like most things, the premium market is much smaller than the "good enough" market. The top brand names for raw denim enthusiasts are still chiefly Japanese companies.

I've bought 5 pairs of Japanese denim from 5 different manufacturers over the past 7 years. If anyone has questions about raw denim, feel free to leave a comment or send me a message.
Google has this disease quite badly, from multiple sources.

It's pretty common elsewhere in SV as well. And is a cardinal error.
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(Update: I put what I managed to salvage up at http://atdt.freeshell.org/k5/).
As does Rust.
Hope you're trolling, but speeding up the process for the most vulnerable in our society is extremely inhumane
Disclaimer: medicine isn't my background, so the following comment could be partially or entirely groundless.

---

So I just took a crack at the concept PDF and the rest of the literature on the site, and there's nothing that I can find which mitigates the risk of flagging a slow-growing or self-regressing tumor as something worthy of attention.

I say this because mammogram recommendations were only recently changed due to the potential adverse health risks stemming from treating tumors which might never progress to a severity warranting treatment [1] as well as tumors which might spontaneously regress [2]. If some of the newer oncology theories suggesting high tumor occurrence and anti-cancer immune responses are correct (my google-fu didn't help me here, so someone else might want to help me with the source), then as a result of Grail, you might start having a bunch of people freak out and undergo unnecessarily heavy treatments for tumors which might otherwise never become cancerous.

That said, I could be entirely wrong, and I wouldn't be surprised if they're specifically working on mitigating this risk as one component of making this screen viable.

[1]http://www.webmd.com/breast-cancer/features/new-mammogram-sc...

[2]http://archinte.jamanetwork.com/article.aspx?articleid=77344...
I do think it would be useful for people who can't afford to go to the prison in person, the price is unreasonable.

I don't know anything about prison but are in person visitations not like they are on tv where the person is behind glass and they talk on a phone? that seems like it would make contraband difficult to get to the prisoner.
It reflected what I was taught in fluid/gas dynamics courses for my degree, and you'll see the same point made in various other places.
You make the same mistake as many other in this thread do.

You confuse two different things.

The question being asked is whether grit is the one trait to rule them all.

My answer to that is no it's not because most people who are successful have grit (but far from all) and many people who have grit are not successful.

And so I introduce another element, luck. Luck is as you say not something you can count on which is the very point here and actually proves both my point but introduces another important one.

You can't copy someone for success. It's not just a matter of having grit it's a matter of being lucky and having grit.

I don't know of any rule or law that implies that something can only be true if you can count on it.

A lottery winner who might keep playing again and again and one day win the lottery have grit but it's still luck if they win.
There's a subtle benefit that I haven't seen any of the other comments describe: the UI is made up of text, and I don't mean that in some curmudgeonly "things were better back in the day" way. I mean that all of the commands you use for navigating and manipulating text, moving between frames and windows and so on all use one consistent interface. With magit, I can be editing a file, hit Ctrl-C, g, then do some git manipulations and switch back to my work with a much smaller mental context switch.

And because all of the modes share that emacs feel (except for the vi-emulation, I guess), that knowledge is transferable across every language you work on, instead of learning a new (possibly proprietary) IDE for each new language.
Wait, this was apparently misreported to me although it still says wonders about the situation. It was a threatened mass suicide that led to concessions. Over a dozen did jump to death. And the worst part of what I originally received.... curtailing the suicides by installing safety nets instead of better working conditions... did happen.

So, yes, that's unusually bad with not many in the U.S. that can compare. I'll be interested if you know any companies in the U.S. where over ten people have jumped off one roof with company installing safety nets.
Pretty soon there will be even less reason to learn (so many) foreign languages, because automated translation is going to get very good, unless you need it on the street.
I used to be bothered by this, and then I realized for every thing I wanted to do in the terminal, 5 minutes of searching would usually find a superior UI to do the same task in an Emacs-native way that I could effortlessly customize, rebind keys, add hooks for, and rewrite functionality live. About the only exception I can think for this is htop; M-x proced does most of the same things but doesn't look as nice doing it.
But Rust isn't a Lisp based on M-Expressions like Dylan is.
this tutorial is terrible I highly recommend finding a different one, and why is it here, its hardly new or news worthy.
I think "the popular God conception" isn't quite internally consistent, at least not the Christian view. We throw around words like omnipotent, yet clearly worship a God bound by certain laws. If not, why would He have to sacrifice His son to redeem us, if He had all power?

I do not believe in a omnipotent God, who lives without restriction and can act arbitrarily. I do believe in one that does His best to help His children become like Him.

I think that principle is necessary to believe in order to arrive at a palatable solution to that question/problem. Any more than that and I'd probably qualify as "preaching".

I do think it's a possibility that people never consider though.
>No one is changing their mind about politics after reading something on Facebook.

That would imply Facebook's influence doesn't exist, and its $340B valuation is a sham.
This accomplishes nothing. Palantir provides this same service on top of GNIP data. Here's a live demo from one of Palantir's own conferences: https://youtu.be/h2NA48iypME?t=559
Weird; I've never needed to do anything more than "export TERM=xterm-256colors" provided I was using a high-color terminal emulator to begin with.
FTA:

Inventor: "We programmed the best surgeon’s techniques, based on consensus and physics, into the machine"

Third Party: “While in a technical sense, semi-autonomous suturing is a ‘grand challenge’ problem of surgical robotics, clinically much suturing and bowel anastomosis is done by staplers which can do the whole thing in seconds,” he wrote in an email. “Clearly the task they chose does not justify the elaborate equipment they used.”

So, they used machine learning to perform a limited part of a surgical procedure, but with freedom of motion and adapting to tissue changes.

At the end of the article they talk about self-driving cars and how we have lane-assist and the next level is taking over. The inventor likens this technology to current lane-assist technology, but it seems more involved than that.

Personally I do not want any machine learning consensus algorithm with control over a surgical procedure in my body. I think the DaVinci type systems (tele-operation, but without autonomy) are awesome -- they allow superhuman precision in delicate surgical tasks.

However, until AGI is a solved problem I do not want an automated algorithm making decisions with a knife to my organs.

Let the automation algorithm highlight portions of the screen or anticipate the next viewpoint, but keep it away from the controls.
That does seem like a public health concern. Normally you'd recover damages from a class action lawsuit or similar, but it sounds like it was common practice at the time so nobody was acting negligent. That's just a sad state of affairs.

Gilead - or maybe even Congress/local states in cooperation with Gilead - could get a lot of goodwill by offering the cure for free in a one-time deal to people who:

* Developed Hepatitis C before 1992.

* Had a blood transfusion that likely contributed to the illness

* Can't afford to pay for the cure otherwise. To start with, let's say that you make less than $60k/year to qualify.

* Don't have insurance that would cover it

It seems about as justifiable as when the government steps in to help after a natural disaster.
In practice, it's done the opposite way. The implementation of work condition standards is a standard feature of trade liberalisation agreements, including the TPP. Manufacturing tariffs are, indeed, a wealth transfer from foreign producers and domestic consumers to the owners and workers of domestic production. Of course, this is a highly inefficient way to do this transfer, and you'd be better off redistributing the broad gains from free trade.

You'd be hard pressed to find a Trump supporter admit that they are looking for government handouts, though.
Same article? https://news.ycombinator.com/item?id=11644597
I can also add from experience: these are a nice bunch of people to work with.
Emacs is a very general and fundamental tool. It's "do one thing well" is "organise textual interactions, via lisp". And that ranges from editing to shell to numerous programming environments to email to web....

I'm actually thinking of picking up Emacs again as a preferred option to a browser.

Eclipse and Intellij may be open source (and I'm sufficiently unfamiliar with them that I'd blown that fact, thanks for the correction), but they're far narrower in scope. That itself tends to be a strike against. Even broadly-used tools -- say, Perl -- can be, pardon the term, eclipsed by others.

Mind to: learning multiple ways isn't a Bad Thing. But being highly mindful of what tends to survive and what doesn't is itself useful.

Emacs dates from glass TTYs, and has survived to mobile devices. I've seen enough of other tools to note the quirks of their own tech origins and how this has or hasn't limited them over the years.

So: consider mine a somewhat informed, somewhat uninformed opinion. Though I'd still strongly recommend Emacs as a durable, extensible, and exceedingly useful skill.
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The protobuf varint format itself actually is pretty expensive to decode-- the way it's encoded pretty much mandates a branch per seven bit chunk (of the resulting integer); you can't tell in advance how long an integer is (as opposed to a length-prefixed varint, where you can).

That's in addition to the encoding-independent overhead inherent to any variable-length integer scheme, which is what mandates the encoding/decoding step in protobuf. Combined, this makes protobuf pretty expensive to decode (protobuf varints are everywhere; they're used for field keys and length delimiters for length-delimited field types).

That's unrelated to ZigZag encoding of negative numbers, though, which is fairly straightforward and computationally inexpensive (it's a couple bitshifts and an XOR).
While the postal address is annoying, I think (currently) having to go there to open a bank account is a bigger deal, since it will be hard to open one anywhere else. Even if you can get a bank account, many payment providers want you to have your business, bank account and residency in the same country (something e-residency won't do).

So while I think the are moving in the right direction, it's still reminds me of government startup programs disconnected from reality. My suggestions would be that they, other than sorting out banking/payment processing:

a) Allow companies to register as LLC or Limited, for increased customer confidence.
b) Give foreigners a income tax holiday, so they can become resident without worrying about paying taxes on worldwide income.
c) Generally make it easier to go there. Last time I tried to figure out how much it would cost to go there for a month and work I couldn't really find any (at least cheap, upfront) prices for serviced apartments and coworking spaces. They need to do more "outreach" (tourist board for entrepreneurs please) than just "look how good we are".
Any good reason not to just use a single sign bit?
<script type="text/java" src="http://www.yourdomain.com/jimboxutilities.jar"></script>

having text/java as MIME type - instead of at least looking up the correct one in Wikipedia makes this implementation look quite uggly on the first sight.
https://en.wikipedia.org/wiki/JAR_(file_format)

Also I cannot imagine a single valid usecase for this.
Passwords are usually under the complexity threshold of copyrightability, but keypairs aren't.

But secrets can have many other kinds too, like accidentally publishing code which is under a restrictive license.
Yes, the company that actively prevents people from obtaining life-saving medicine for billions extra in profit is more reprehensible than the company that makes no pretenses about having anything to do with life and death.

Creating the cure was admirable, what it has done with it is reprehensible. It certainly has the right to make a significant profit. But a monopoly on medicine paid for by dying people with no other options does not accurately establish the value of curing the disease.
It doesn't make any sense unless you count human labour costs at $0/hour.

You take $10 of taxes and $10 of work ($20 total), and give $10 to the worker.

But maybe 50% waste is still better by order of magnitude than average government projects.
This would pretty much projects like Wine or GNUStep would be illegal. For those who don't remember the days of the Microsoft Empire, this is a pretty big thing.

Once AWS becomes a monopoly (which should happen anytime in the 5 to 6 yrs), the only way to challenge the gorilla would be to build an API compatible competitor.

This ruling would make it illegal.
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California used to have a Prisoners' Bill of Rights. It was repealed in 1994.[1]

The California Police Officers Bill of Rights was passed in 1974.[2]

[1] http://articles.latimes.com/1994-04-05/news/mn-42375_1_priso...
[2] http://www.ocregister.com/articles/-225344--.html
I did do that math wrong, but to be fair, the article is comparing apples and kumquats. $26 billion is how much Gilead has in cash, which has little to do with Sovaldi at this point. $1 billion profit (let's say that's annual, rather than over the life of the drug) on an $11 billion purchase would be less than 10% annual ROI. That's very low for what was still a very risky investment (unapproved drug).
I am disappointed that the interview did not include more of DeLillo's motivation for choosing to research and depict cryonics, or his personal take on it.

Their underhanded marketing ploy worked ... now I have to buy the book!
There is no requirement for e-residents to have an Estonian address. Quite a few tourists who have only been in the country for two weeks (me included) have an e-Residency card.

Maybe you mean a requirement for incorporation or something?
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Interesting that you mention that. Shortly after Gilead launched Harvoni, Abbvie (Abbott's spun out drug unit), launched their HCV drug (Viekira Pak).

Abbvie decided to compete on price and immediately locked in a couple very large insurance companies. Basically, they offered a discount and the insurance company/PBM (Express Scripts) agreed to lock out the Gilead drugs.

This caused Gilead to have a bit of a fit, so they offered a competitive discount and locked in the remaining insurers.

If you look at Gilead's financial statements, you'll see that the average discount went from somewhere around 20% (including mandatory gov't discounts), down to 46%. That means the average price for Harvoni dropped from $75K down to $50K. Almost half of list price.[1]

Interestingly, the average price in the US is now lower than the high end of EU prices.

And people say there is no competition in patented drugs!

[1]http://blogs.wsj.com/pharmalot/2015/02/04/what-the-shocking-...
The suggestion from OP WAS in fact that a billion dollar of profits was "reasonable." Read above copy pasted quote.
Inventing is dead, killed by the anti-patent lobby. It's really hard to make money by inventing any more unless you do a startup, which is a different skill set.
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I'm also waiting for people to exploit these errors and DDoS the systems. Know a particular route will get an autonomous car into a dead end or off a cliff? Order 100 pizzas to the address with stolen credit cards...
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Entertainment is one thing, but I think far from the only factor in spreading this.

I tend to think that US is just somewhat ahead in most developments, and trends then come to Europe. In addition to near-hysteric control of what children do, we'll have gated communities in fear of crime, we'll have politically correct "safe spaces" in universities, and whatnot current US phenomena.
To solve that problem, I always call it GLinux but the 'G' is silent.
I saw at least one IE6 specific hack in their pages.
This is nothing, what about attending FOSDEM and seeing the majority carrying iDevices?
Who limited it to one data signal? I sure didn't.
Absolutely. Possibly millions of people were exposed to HCV through the blood supply before 1992, and many still don't know they were infected. Since HCV may take 20-30 years to show symptoms, it is a potential public health time bomb. We luckily have a tool to defuse it.

For example, essentially every hemophiliac was infected with HCV due to dependence on clotting factor, many also with an HIV co-infection. 80% develop chronic liver disease.

Those populations aside, "youthful indiscretions" or even chronic addiction are not reasons for (potential) death sentences due to lack of effective treatment.
> Yes, the company that actively prevents people from obtaining life-saving medicine for billions extra in profit is more reprehensible than the company that makes no pretenses about having anything to do with life and death.

So the moral impact of a company's actions depends not on the net good done by that company, but on the "pretenses" it does or does not put on? It's morally better to waste natural resources on frivolities like new iPhones every year, instead of saving some lives (but not all)?

And if it's morally reprehensible to not save a life when you have the power to do so, aren't all of Apple's customers morally reprehensible for buying iPhones? That money could literally save the life of someone in the world that lacks basic necessities.
Yeah probably Twitter for three letter agencies for a multi-million dollar contract is coming out soon is why.
Why did you think Microsoft was coming around? Their legal actions hadn't improved. They just spent more on PR.
So India does not have prisons or similar laws for treatment of prisoners?
> this is a public company. People have the right to ask questions.

He did ask the question. You have the right to ask questions of a private company too. And both private and public companies have the right not to answer. Everything they're required to make public is already in the filings. You seem to be indicating that they're required to say more, but they're not.
I feel completely differently. As soon as someone shows me a table that says

Human Surgeons Mortality Rate : 1%
Computer Surgeon Mortality Rate : 0.5%

I'll be sold on the automated surgeon. And I think this will happen WAY before AGI is solved.
I think part of the miscommunication may lie in professional idiom. In medicine, all diagnosis is provisional and statistical - which both elevates "probably" to "certainly" in casual conversation, and renders most absolute statements hollow. It's just an automatic translation that has to happen: when you tell someone with a three-day sniffle that they have a cold, it's an absolute statement aloud, but in your head you have to honestly say "99.999% cold; 0.0009% HIV; 0.0001% cancer." And you have to treat them accordingly, until proven otherwise, because if you try to rule out cancer on everyone with a sniffle you're going to actually kill more people with complications than you'll ever save.

"This person has X" most of the time means "X has a strong statistical advantage in explaining this patient's symptoms, so we're going to pursue treatment for X until accruing evidence suggests we shouldn't." I guess that's not always true, given a few things that exist by definition, but it's mostly true.

And that's generally good enough, since... well, statistical masses tend to obey statistical properties.
You don't think it's fair to price a product relative to the wealth in a given country? I think it's quite fair to be honest.
Even if they didn't get disenfranchised there would be no "voter block" of ex-cons that would wield any power. What is right frequently takes a backburner to what is profitable or what is politically palatable. Its ineffectual government through and through.
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Microsoft also has a competing platform to Java that might benefit greatly if Java's open foundations were shaken: .NET