skysight-inc/HackerNews huggingface dataset:
Absolutely. You have 'rogue' cells that go on independent replication programs all the time. But there are a few checkpoints which are no-go if a cell passes them - they are immediately forced to die. These include, short telomeres, lack of proper DNA repair, and ability to respond to induced-suicide signals. In order for an otherwise 'cancerous' cells to be a problem, it really has to have developed processes that ignore ALL of these (few) checkpoints. The chance that the particular mutation in that cell includes a mutation to overcome ALL of those hurdles simultaneously in a single cell is the chance you develop (a harmful) cancer. A change to nearly any other gene will cause one of those checkpoints to kick in and force the cell to die.

The DNA damage checkpoint is interesting all the way through public health policy in 2 cases: 1) The BRCA gene is a DNA repair protein. Women with a mutated brca gene are missing one of those 3 checkpoints. 2) HPV (for which we have a complete vaccine) is of a type of virus that is generally destroyed by your DNA-repair machinery. However HPV, being evolutionary wily, has a specific mechanism to shut down your own DNA repair machinery that would otherwise catch the foreign invader. Hence, HPV 'causes cancer' by deliberately disabling one of those checkpoints.
The biggest and scariest issue is that all of these celebrities are going completely unreplaced.

I am a fan of rock and heavy metal, and it is clear that rock stardom is literally dying off. The days of filling American arenas with rock concerts are quickly coming to an end, and that deeply saddens me.

Where are the twenty-something kids with attitude who will replace a band like AC/DC? Is Justin Beiber the best we could do? It's pathetic. Even a guy like Bon Jovi... Who is next in that line?? Seems like nobody. It's depressing.

This is why I'm going to as many shows for bands like Iron Maiden as possible right now. When it's over, rock and roll may truly be dead.

This is one of those moments where I realize I'm getting old. I never understood life extention and the quest for immortality. As things change, eventually they leave you behind. Find me a 90+ year old who really cares to stay. And that's how I'm going to feel when rock and roll dies.
The Making of a Modern Myth: Edward Leedskalnin and the Coral Castle
A Paper Internet of 1932
Well it's not art, it's a boarding pass. They ought to be reusing ideas whenever possible.
Because critical thought was murdered and replaced with marketing.
I find it difficult to find friends who are reliable. Many who seem to like me when we hang out are almost impossible to make plans with. They often respond by saying they need to check their schedule. Perhaps it's just a polite no. When we do get together everything is great but it seems so shallow. I have a lot of friends like this.

Beyond the reliability issue I find it particularly hard to find highly intelligent friends. Most of my intellectual stimulation comes from my work but sometimes I find I want more. Many of the people I meet who are intelligent and in my field are socially inept. They can be intellectualy stimulating but deeper friendship is difficult.
I like this one as well:

Fibonacci(n) = (Φ^n - (1-Φ)^n) / √5
(Where Φ = (1 + √5) / 2)
Some notes:

Yeah, per a later study as described in Wikipedia, slamming the control rods home was the final fatal mistake, because their tips were inexplicitly made of graphite (a moderator if pure enough), and they displaced light water that in this reactor design was a neutron absorber. Add the (illegal in the US) positive void coefficient of this light water used for cooling, and you get exponential growth of the nuclear reactions until the reactor sufficiently disassembles itself.

"500 roentgen" is something more like about the LD50 for generic radiation due to bone marrow effects, so you'd expect around half of those viewers to survive without treatment. Add another 50% and the lining of small intestines get killed, which is not survivable in any way.

The wildlife is tough to beat. Wolves and bears and big cats, even wild horses, thrive inside the perimeter.

Which suggests that the dangers of radiation are a bit overhyped. Then again, we humans have longer lifespans, and thus more time for a cancer to slip by the body's defenses.

This "3,000 year" estimate is interesting. The metric I've read is that generic US civilian nuclear reactor waste decays in 600 years to stuff that's no more radioactive than the ore it was mined from, which I grant you is not stuff your children should be rolling around in (and that, or rather the radon from it, is death to smokers, but so are many many other things when combined with smoking). This corium is not quite the same thing, though ( https://en.wikipedia.org/wiki/Corium_(nuclear_reactor) ).

A million years is ridiculous, a definition of safety that's self-defeating.
Cool idea. Just signed up!
I can't name the research on this topic off of the top of my head, but yes to both questions. Cancer is a common occurence in all mammals and we have evolved many self defense mechanisms, including telomeres, to fight it as animals started living longer and longer. One of the most promising areas of oncology research is immunotherapy, for example, which guides your immune system to attack cancer cells that havent been recognized as targets.
A they already built a solar aircraft and B they say it can scale to 50x the size and carry 50 people. IMO, that would be more useful for lifting cargo vs people.

Second wing area and lift is related to velocity (not power) right before you stall outside of that it's a looser connection. Velocity is indirectly related to power in steady level flight based on drag. Drag in level flight is a function of weight, shape, altitude, and velocity.

Economicly I don't think this is a good idea. Physically it seems possible with cheaper and more efficemt solar cells it might make this more reasonable up to a point. Especially if they can boost altitude and thus speed.
The difference equation approach (computationally fastest) can be used to derive a elegant closed form solution that relates to the golden ratio.

Fn=(1+√5)^n−(1−√5)^n\2^n√5

This deravation is pretty accessable and if you want to show off in code tests :)

http://www.cut-the-knot.org/proofs/BinetFormula.shtml
E-commerce status quo for 2016
I have been meaning to research this stuff for a crazy automotive application I have in mind. thanks for the pointers.

(Ps hello fellow TR35er!)
And yet... A friend was walking in soma watching a video on his iphone. He noticed someone peering over his shoulder; the dude grabbed the iphone and took off. My friend chased him, and this is where it gets interesting.

The thief, instead of outrunning my friend and/or just dropping the phone, punched my friend. My friend plus a bystander who saw the punch ended up chasing the thief down. SF police don't give a fuck less about a stolen iphone, but that punch? The thief is doing 2-4 years.
I met half a dozen very good IRL friends first through online discussion (though not on HN).
I think it would be under 30 seconds if photoshop is already open.
Article is completely wrong about not being able to decrypt other clients traffic when the PSK is known to the malicious actor and the authentication handshake is able to be observed.

This is well known and even documented in wiresharks guides.
see Gotchas -> "WPA and WPA2 use keys derived from an EAPOL handshake,..." https://wiki.wireshark.org/HowToDecrypt802.11
I'm 24 now and I can remember from eighth grade through graduation there was this assembly/ seminar where they brought someone in and berated you to not post stupid stuff on the Internet (MySpace, AOL instant messenger era). Seemed to be pretty effective..

Also, who's the victim in your hypothetical? The kid getting bullied, or the kid who gets caught bullying through this tool - because it sounds like the former.
I like the matrix math one mentioned in the post, although I implemented the matrix arithmetic by hand.

That provides an opportunity to discuss the optimization involved in performing integer exponentiation, so you aren’t depriving an interviewer of an opportunity to have a productive conversation about programming.
What cars are hot in Victoria?
Lots of "unimportant" people die every day.
Small differences eventually become a difference in kind.

We are used to thinking about concepts like "in public" and "spying" in traditional human-scale situations. Many of our cultural and legal structures implicitly assume human-scale limitations; we understand that you lose your expectation of privacy when a conversation moves from inside your house to the public shared spaces like the street.

We are also used the spread of information as something that has noise, limited reach, and having a cost that limits both how far the information spreads and how long it lasts.

Combined, this mean it was usually easy say things that might technically be public, but in practice were de facto a private conversation. This is great for kids, who are still learning how society works, risk assessment, and how they want to express themselves publicly. Children need this kind of sorta-public, in-practic-private environment so they can learn and develop. This will often involve making mistakes. A vast majority of the time we simply call this "being a kid". The public side of the situation allows for a parent/teacher/whatever to (hopefully) offer education when a kid makes an embarrassing or rude comment - or a post that could be interpreted as threatening - while the transient nature means the child can move on having learned from their mistake.

What is happening right now is that the underlying assumptions are changing. Information no longer goes away. Far more is recorded and the de-facto-private aspect of many situations is being eroded. In some situations, it's already gone. When life is recorded as the norm, there is no room for mistakes, no allowance for growth, no room to discover by experiment0 how social expression works. We already see this on the internet ever time someone complains about hostility in forums, "cyber bullying", and even the moderation drama here on HN.

This means we need new definitions for what "in public" or a "public post" means. We really need entire new social structures to deal with this brave new world of computing and data. This will take time to convert. I don't know what those social structures should look like, but I do know that applying pre-information-age heuristics to modern internet-based, always-recording situations isn't the answer.

TL;DR - see CGP Grey's recent discussion of why precedent matters: https://www.youtube.com/watch?v=e-ZpsxnmmbE
I agree with this. Everyone has something unique to offer, and not everyone enjoys philosophizing over "deep" conversation topics. (Although I will admit it can get annoying at times when someone spends ten minutes listing all the coupons they clipped from this week's Kroger advertisement...)
This post is about web bloat, not about app platforms.
Sorry - mixed up immediate/ retained
Wouldn't Microsoft have sued the ReactOS guys then?
Michael Tsai often does so on his apple-focused blog (e.g. Paid App Store Search[1]) but he hasn't gotten around to this discussion yet.

[1]http://mjtsai.com/blog/2016/04/15/paid-app-store-search/
The Theoretical and the Actual
Inspiration, sure. The copy of Southwest's Ding! was funny though, as they literally copied the text that referred to partnerships with ATA.
Complete fail. Ryanair first, customer last as per usual. Why do they make their customer print advertisements? Have they done anything to reduce the amount of ink required?
I think the Carnegie book isn’t that great, because it’s easy to misinterpret the rules. An often mentioned strategy is to be a good listener. This gets repeated ad nauseam, but is it actually true? I found that people become more open if you put a story on the table first. It’s like an investment. You open yourself a little bit and tell something about yourself, whereas a question about the other person asks them to trust you first.
This formula is attributed to Binet (1843).

See https://math.temple.edu/~reich/Fib/fibo.html for more on the Fibonacci sequence and the golden mean.
I went undercover as a bot for 2 months, and that's what I learned
ImageFap's rather unusual PHP job posting for a NSFW site
Yeah, this. A lot of wise, learned-it-the-hard-way advice here.

Growing up with bullying and beatings, kinda wires your adult brain to seek out relationships with controlling people. That's its comfort zone, it doesn't know how else to be in the world.

One way to start rewiring, is to figure out what YOU want in a partner. I don't mean looks, but qualities and values and behaviors. Assume you had a relationship with a beauty - how would you want that beauty to ACT, toward you and toward others?

Sadly, physical perfection is a really inefficient criterion for your primary sort. It's fun for about a week ... but then you're stuck with whatever random stranger is behind the mask.

Could be that your manliness is just fine, but your picker needs a tune-up.
Join Google.
We do know that smaller (shorter lived) mammals at least have significantly shorter telomeres than humans.

Here's a paper comparing max life span (MLS) against body temperature, body mass, and telomere length. [1]

[1] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680702/figure/F...
someone once said something along: any relationship will thrive to a degree to which value is derived by both sides

This helped me understand a few things. We all have childhood friends that once made sense but now if we met these people we wouldn't become friends. That's the exception to above rule, and i'm sure there are a few others, but generally that is a good way to understand why a friendship is working or ceases to be useful. It's something you can also use to acquire new friends or improve existing relationships. The value you offer may be as simple as being available (i.e. available to go out to meet possible romantic interests, available to pursue a new hobby together, available to blow off steam after work), actually listening and offering advice (advice part only works if the person looks up to you on a given subject and asks for it, unsolicited advice is the worst), being positive and seeking/seeing positivity in every situation/person (i've had friends that really helped me realize that people are in different stages of their life even when they seem obnoxious there's probably a good reason for it at the time so we shouldn't be quick to criticize and it's mostly a waste of time anyway). Most people don't actually think about this or put any effort into improving their value proposition but you'd be surprised how much difference that can make.
If Weed Got Branding Like This, Maybe the Man Wouldn’t Hate on It
You're sure in for a surprise then.
And Enterprise Management has spoken!

Ignoring the fantasy that I would get to use something higher level (than Java) for most work...

Not everybody panics if they have to write code outside of Eclipse or Visual Studio.

Once upon a time, there was an expectation that programmers knew, or could learn, more than one language.

Sorry about the rude response, but I'm really sick of the dumbing down of everything for (counterproductive) business or "risk management" purposes. To paraphrase, "average performance" in this industry is pretty poor.
Ok, awesome. Now I'm wondering if we PCDOS in a broswer...

1) Can we say the claim (I think of mozilla's) that the web was going to be the new OS is true?

2) If DOS today, will it be 5 or 10 years before we get BSD or *nix in the browser?
I worked on a boat in the middle of the ocean for many years. I've been grounded for the last few years and tried to make friends. The experiment has been a massive waste of time and energy. I did so much for so many people trying to be nice and helpful and got so little in return. From an economic point of view, I'm completely self reliant and don't need anything from anyone else. I invested so much in other people and I got nothing back.

There is one case where I watched some guy's dog for a weekend, took someone else's boat into the ocean to save him when his engine died, helped him move all this uncles' stuff after the uncle committed suicide, go drinking with him downtown even though I didn't want to go out, ect.. I moved into a new apartment and needed help putting up new blinds. He kept making excuses to not help me even though he is a contractor. From now on, I don't help other people. I work, make money, and if I need help, I'll pay a stranger. I'm fine with that.

I've grown convinced it is a myth that we need friends.
>The problem with hiding the tracker in the frame is the GPS and GSM antenna will be blocked by the metal tube.

Not true, there are multiple battle-tested solutions out there, like these: www.spybike.com
I think the question of the OP is why don't the police do anything? It is their job after all.
The thing is... I have to find something interesting about folks and the activities going on to even be motivated to keep up interaction. I need something to be curious about. I can learn a lot about life by reading and random conversations with random folks. This is one of the greatest things about being an immigrant in language courses, and one of the reasons I'll do another solo trip to Amsterdam - people open up in coffee shops (though I understand that is partially because I'm female).

That all said, poplular culture often remains strange and unusual to me, along with the things people do with their time and the things people seem to like to talk about. I once googled who the Kardashians were because it came up in small talk and folks wouldn't believe that I quit watching television (outside of the random show). I watch conspiracy theories for fun while working on artwork, which is also incredibly boring for a great deal of folks to talk about. I don't have the formal education to keep up with some topics - for example, I read HN mostly because I think it is important to know some stuff about these sorts of topics and because I have great hope in technology, but not because I'm personally involved (and I learn quite a bit, thank you every random one of you).

I really wish it were as simple as you say, but forming anything long-lasting with some of this stuff has proven to be a futile thing. I'll take the random friends I wind up getting and be happy with that.
Why do people always want to know the person's identity? This is so selfish. I feel they either want to know it because they want to be the first to know or they just hate not knowing. Shallow and selfish. Yuck.
My recollection is that the closed formula (with phi) is derived from the generating function as well, though the derivation was nigh miraculous when I saw it done.
No problem, it's especially hard to find external feedback for side projects and experiments so I try to give it when I can.

> I assumed it works correctly because it fixed my "too many open files" exception

It works, so at the end of the day that's what matters. The client vs server question, from my perspective, ultimately comes down to a question of test realism; in a real-world deployment you couldn't limit connections with client-side code because there are multiple clients. That's what I mean by "it doesn't make sense given that the error is server-side".

> Can you clarify why you think my use of semaphore does not make sense and why your suggestion is better? What is the benefit of dedicated coroutine?

I'm saying that mostly, but not exclusively, from a division of concerns standpoint. You're acquiring the semaphore in a completely different context than you're releasing it. On the one hand, that's partly a programming style issue. On the other hand, it can also have some really important consequences: for example, it's actually the event loop itself that is releasing the semaphore for you when the task is done. Because of the way the event loop works, it's hard to say exactly when the semaphore will be released. You want to hold it for the absolute minimum time possible, since it's holding up execution of other connections in the loop. Putting it into a dedicated coroutine makes it clearer what's going on, makes it such that the acquirer and releaser of the semaphore are the same, and means you are definitely holding the semaphore for the minimum amount of time possible (since, again, execution flow will not leave any particular coroutine until you yield/await another). In general I would say that releasing the semaphore in a callback is significantly more fragile, and mildly to moderately less performant, than creating a dedicated coroutine to hold the semaphore and handle the request.

Does that all make sense?

> Either it does not fail at all, which seems unlikely, or it fails silently, which is more likely and is bad.

That's a fair statement, I think. As an aside, the print statement is slow, so keep that in mind. It might actually be faster to have a single memory-mapped file for the whole thing, and then just append the error and traceback to the file. The built-in traceback library can be very useful for that. That's also a bit more realistic, since obviously IRL you wouldn't be using a print statement to keep track of errors. On a similar note, because file access is so slow, you'd be best off figuring out some way to remove the part where the server accesses the disk once per connection entirely. On a real-world system you'd possibly use some kind of memory caching system to do that, especially if you're just reading files and not writing them. That allows you to use a little more memory (potentially as little as enough to have a single copy of the file in memory) to drastically improve performance.
I fail to see what laws he's broken. If you're going to allow a "free market" healthcare industry, this is the result. Being a dick isn't a crime. Neither is being a price gouger.
11 years and 1 day of YouTube First video here
Surprisingly often I find myself thinking about poker in everyday life (even while not playing poker, that is). And surprisingly often I find something I learned in poker is also applicable in life outside the game. In this case, the concept of variance comes to mind. Basically that values (for instance number of deaths of celebrities) are spread out. Sometimes there are more, and sometimes there are less. And that's just how it is, it doesn't automatically mean there's a trend change either way.

Lots of pages out there to read about it, here's one that might give more insight than my comment: http://www.thepokerbank.com/strategy/other/variance/
I would only buy one that charged while I rode my bike.
>Where are the twenty-something kids with attitude

Attitude is not relavent anymore. We are all introverts now, people have wide varieties of musical tastes and preferences .there is huge amount of experimentation going on in music due to the fact that process of creating music has become much more accessible. There are tons of awesome music being produced everywhere you just have to dig deeper.
What did you like about this article? The headline suggests it's going to explain something new and it just states the obvious. I see many articles fitting this pattern. Kind of the "5 ideas to lose weight" we saw a while back.
WebAssembly is even not supported natively in any browser, is it?
An amusing sample of the prose:

Most usability studies last from 1 to 2 hours because it's hard to recruit users to come in for longer tests. In fact, unless we're testing kids — for whom an hour is the max — we usually limit our test sessions to 90 minutes. People tire after an hour or two.

Wonderful stuff, as is the norm from the Nielsen Norman Group.