skysight-inc/HackerNews huggingface dataset:
This is exciting news indeed. During my internal medicine training, I was taught to ask questions about family history, medical history, and environmental factors (e.g. smoking, childbirth, etc) to assess my patients' risk for developing various cancers. For the general population the genetic component of their cancer risk equation is by far the most important, and family history is a very imperfect way to assess this risk. A doctor asking a question about family history is a test, just like any lab test. And often doctors either phrase the questions about family history incorrectly (PCPs have about 2 minutes to ask this question and get an answer in the typical office setting) and/or often people aren't aware of their family history. In addition, spontaneous mutations are not uncommon, and family history does not provide any insight there. Convenient genetic testing like this would allow me to get immensely more accurate information about the risk profile of the patient sitting in front of me. It is truly amazing to see this age of precision medicine, where I can more accurately quantify my patients cancer risk, emerge in my lifetime.

For certain genetic diseases (e.g. Huntington's) assessing risk or making a genetic diagnosis is controversial because there's little that can be done to prevent or treat the disease. Fortunately, cancer is very different. Being able to more accurately quantify risk helps physicians adjust screening protocols aimed at early detection and treatment.

I also appreciate the way Color is attacking this problem: Increasing patient access by dropping the price, providing genetic counseling resources, and participating in groundbreaking studies led by top institutions.

Great work, and looking forward to seeing what's next!
I do not understand the point of this comment at all. Everybody doing 'Apply HN' is looking for outside capital. Pinboard has a loyal following that would probably be interested in additional value being added to it.
Well so far MSFT and GOOG are regularly slashing prices to keep up with AMZN's price cuts. So we're in the price war stage still, not much at the differentiation stage.
All hires
What kind of job do you have where someone tells you the algorithm? I can't imagine my PM saying "Let's count recent events by storing it in a hashmap and using a linked list to track which elements have expired, can you code that up?"

Instead, the PM might say "We need a system which can count how many unique events of each type has occurred in the last 100k requests, with small impact to time, high accuracy, and up to 100mb of space"

But even that would be unusually specific. It would usually be: "the service breaks sometimes, can you figure it out?" And then the engineers figure out that it's because of unusual event distributions, and they figure out what needs to be done, how much space / time they can afford to do it, etc. For instance, do you trade off accuracy by having a periodic job flush old events out of the map? Do you quantize by time to save space at the cost of resolution?

That's what I do at my job, and that's the kind of question I see in interviews. If a candidate is expecting to have the algorithms dictated to them, then I would not consider them to be a software engineer.. coding up a program from a specification would have been a technician's job 30 years ago (now largely automated by compilers, synthesizers (for HDLs), and other tools). The software engineer should be coming up with solutions, which often involve using algorithms and data structures.
What's the point? If you didn't take that job, presumably you got something better instead, and that's on your resume.
That's outsourced to a specialized company.

Compare https://investor.yahoo.net/sec.cfm and http://investor.fb.com/sec.cfm

Amazon investor relation uses another company http://phx.corporate-ir.net/phoenix.zhtml?c=97664&p=irol-irh...
I can't say, because I didn't enumerate them. I only counted them. See

http://tromp.github.io/go/legal.html

for the method used, which is a form of dynamic programming.
It's worth noting this was originally a blog post on Stephen Wolfram's personal blog, where you'd expect an author's voice to permeate the content (although that didn't stop people from complaining about his other blog entries). I personally appreciate authors dropping their own biographical details when they write about something else, it gives it a more personal voice. Plus, Mathematica is relevant. It's not as if he's doing product placement for Purina Puppy Chow, which is a great way to feed your growing puppy and give him all the nutrients he needs.
This is good. That's all I have in me.
> out-of-touch "activist" investors clamoring for short term growth and dividends

The company has 230 billion in the bank, they can surely remunerate their investors. OR invest in their own company more, quality is down over the past 5 years, they can invest in more engineers. The hardware lives extremely lengthy update cycles (on average 3 years? MacBook?) There is a lot they can do with their capital that will provide them with long term growth. Products like the Apple Watch wont do it.
"The constant inflation made it only possible to issue bonds in a foreign currency."

Why is that?

I think the problem in this discussions is that every side come from a different conception about what is and where money comes from.

A sovereign govern with a floating currency don't need financing from private sources in its own money. That's a simple fact about how money is really created. If we don't agree in this first, all posterior discussion is pointless.
> The distance between 0 and 1 is smaller than the distance between 0 and 2.

This is correct. However, the number of real-valued points between 0 and 1 is the same as the number of real-valued points between 0 and 2.

> The number of points between 0 and 1 is larger than the number of rational numbers.

This is also true because there are uncountably many real-valued points between 0 and 1 and countably many rational numbers.
Well, while the hyperbole might be grandiose during the stages of bitcoin's infancy - everything claimed is plausible if it can scale. At least to the point of being a global currency and transfer of value alongside govt and central bank fiat.

Sometimes the economic winds favor different assets both liquid and long term stores of value.

Bitcoin adds a legitimate, scarce, immutable form of ownership of something that can be transferred with the least amount of friction of any other asset (including cash).

Hyperbole or not, where it is now compared to 2009-2012 is extremely impressive. It's an exciting space to watch develop over time, love it or hate it.

I think those that don't understand it but are quick to judge or regurgitate the opinions of their peers (it's a ponzi, tulip mania, etc) are just as hyperbolic and ignorant.

I don't see how anyone can argue that bitcoin and it's blockchain is not an impressive, elegant technological solution to a problem that needed solving.
Doesn't that work in the opposite direction? The "true" breakeven point is much lower than what the studios claim, not higher.
I believe that was "toejam".
An aim bot doesn't have to play all the game for you, it doesn't need to think. I don't know how it is currently as I haven't played FPS games in a while, but back in the day, there were aim bots that would just activate when a target is in sight and take over, aim and shoot.
Uh, we didn't know better? I don't even understand how you could force guilt on ignorance
Alluxio Unifying Access to Distributed Storage
The point of working for a company is to exchange services for money, not to feel cared about. It's the responsibility of the individual to assess whether what they are being offered is going to work for them. There's no hidden information here - had Talia done a budget she would have realized that her plan was not going to work.
This guy's failures didn't cost anybody any money (not getting grants doesn't count, that's like saying you cost people money by buying a lottery ticket and not winning).

Anyone who's worked for a failed startup (like moi) has cost people money, sometimes some serious dough. And it really sucks when you know you've cost people money, even if that's part of the investor process.

Ergo, this isn't a very compelling list of failures to me. Good idea, though.
Jeff just made $6.1B afterhours...
I've mentioned this before here at HN and I will do it again. I think Stallman contributed a lot.

Licensing such as GPL has been instrumental for the expansion of open source. That is what helped open source to expand and become integral part of everyone's lives.
RMS is in the same collection of great hackers that Dennis R, Linus Larry Wall, Guido, etc are in. Thank you RMS.
Well, if you emitted it all in a beam away from the plane of your galaxy, that might make you very stealthy. That would impart thrust on the sphere... which if it wasn't perfectly balanced might cause it to wobble, and then start rotating...

... and now we have a sci-fi reason for quasars. :)
>> you also have to face a 3 month review that could very well end up in you being canned?

I think that this (3-ish month review) is true pretty much anywhere, if even as an informal process.

edit: clarity
Zuck Built a Giant Data Temple in the Arctic Circle
That would work for all positions regardless of legality,
which are in 1-1 correspondence to {0,1,2}^(19*19).

The count above is for legal positions only, i.e. those where every connected group of stones is adjacent to an empty point.
> wouldn't it still be easier to live here than on mars?

Maybe. What if it's an artificial plague? What if any other number of catastrophic events cause the collapse of the civilization here?

Having multiple settlements elsewhere is insurance.

And, while Mars is one interesting place, there are other rocks we could easily settle and mine for resources. I don't think Mars should be the first we tackle (I'd go for the Moon first) but I'm perfectly fine with humans spreading all over the solar system.
I dunno, seems pretty reasonable to want a dividend payment. Apple is just sitting on a mountain of money and not doing anything with it, why keep all that cash out of the market?
You're allowed to say "fucking" on HN.
11 Tips for Startups Pitching Big Companies
So if I hire someone, it's my responsibility to find out their living situation and expenses and calculate if they can afford to live on what I'm paying them? Personally, if an employer tried to violate my privacy that way in the interest of protecting me from myself, I'd walk.
He's an openbsd developer, he's posting about openbsd. Hence the talk of how things got to be into older BSD systems and made their way to openbsd.
India's very own GPS is ready with seventh navigation satellite launch
The only way I can imagine it being that synchronized is if evolution itself is somehow tightly coupled to cosmic inflation.

Here's the speculation in more detail:

Evolution can be viewed as an information transfer mechanism that learns about the universe and transfers that information into the genome. (This is one interpretation found in evolutionary information theory.) As the universe inflates there is more total information in it, and therefore more information for evolution to learn. At certain points, a kind of information density "critical mass" is reached and phase transitions occur: the emergence of life, complex life, cooperative/multicellular life, higher order intelligence, industrialization and complex society, etc. Since the total amount of information in the universe is (we're speculating) tied directly to the arrow of time, this occurs simultaneously everywhere at approximately the same time.

Again this is hypothesis bordering on speculation since we do not know of any mechanism that directly couples information content to cosmic inflation like this, or even how we would go about measuring such a thing objectively. For instance it's not possible to differentiate between random and encrypted data using Shannon information measures, so what statistic would you use?
Doing what?

300 hours / mth approx equals 14 hour working days. That's not unusual. But if you are feeling burnt out, then take a break or change jobs. There's a big world out there!
It's probable this preview is actually using the Linux Subsystem, which is fairly complete... And it makes sense.. it also makes a lot of sense in terms of the direction that .Net core has been taking, so that they can be deployed under Linux docker containers more easily.

Although I find a lot of the Azure services a bit too low-level, it's been very easy to build simpler interfaces on top of them, and get a lot done quickly. If this is anywhere near as nice on Azure as what the Joyent cloud's docker support looks like, it could be very interesting indeed.
https://news.ycombinator.com/item?id=11573172

https://news.ycombinator.com/item?id=9943589

https://news.ycombinator.com/item?id=11308679
More like a stepping stone to Saturn's moons and the asteroids. Once we get used - and capable - of living without a planet, there is little reason to bother with deep gravity wells.
These are all deprecated by the way. I just alias them now since egrep is muscle memory and hard to break.
The coolest thing I've seen is an internal IBM project that organizes the news:

http://news-explorer.mybluemix.net/
I'm becoming a fan of board / card game ports.

Ascension: Chronicle of the Godslayer
Neuroshima Hex

Both play really well on small screens and the IAP for expansion packs have been worth it.

Ascension multiplayer can also be played over several days and you can multiple games going. So take a few turns, come back later when your opponent responds.

I believe NS hex is the same but I'm not very good yet and have not tried.
No, more like Eric S. Raymond with mirror-image political views.
Hey HN! I'm Vishal. One of the team members behind WedWell(https://news.ycombinator.com/item?id=11441020).

We're somewhere in the top group of entries with 43 points. I wanted to say that regardless of whether or not we get selected, we really appreciated the ideas and exposure that came from our discussions on HN. A handful of our first clients named HN as the reason why they came to us! Some of the ideas discussed are already being planned for our service. We applied to YC the regular way, and didn't get in. This way we got a bunch of feedback and some traction. Net positive for us.

Dang asked above how best to sift through the applications to give the community final say. I was reading through some of the ideas posted here on how to do that, the one that seem to resonate here with me was the one abhi3 posted above. I'm just worried that a public vote is easily gamed.

Another way to do this is to select the top 10, and get the YC partners (or some trusted groups within YC - perhaps the last group of YC alum?) to vote on the list of 10. I think it would be nice to see what the end vote looks like (release the vote count), and have select YC partners provide some quick feedback for those who are voted on.

Thanks again.
Web Project Managers: Being Nicely Negative
That's different... That's just the standard UX of their mobile autocomplete. It's the same on iOS (I type "f" and it autofills a URL - next letter I type is appended to the end of that URL, slash and all).

This is a problem with how it's interpretations the encoding of characters - they should be escaped by default and be able to be enabled with a flag if there's a valid use for them.
There are two parts... there's the Linux Subsystem for Windows, which is the Linux ABI... Ubuntu for Windows is all the Ubuntu userland running via LSW. It's probable that this Docker system works with LSW as-is.
This is a fair, if terse, summary. However it should be more explicit with the practice accepted as potentially the most evil use of pie charts: any comparison between two, or more, pie charts where the whole has also changed in some fashion. This is most commonly seen as some breakdown of budgetary expenses compared between two years where the total budget has also changed. Attempting to depict this additional change by making one pie larger doesn't work as the eye is too easily fooled between angles and areas. So unless you can somehow assure the audience that the two pies have the exact same base don't compare pie charts.
Yup! SeekingAlpha came up with a timetable[1] for Apple a while back. Assuming a 15% increase in cash each year, they could go private by 2020 under best case scenario.

[1] http://seekingalpha.com/article/1725412-buyback-apple-could-...
BitPay also has the option to give you Bitcoins instead of fiat. (Or a percentage of each). We have no clue how much Steam is keeping in Bitcoins.
Like getting your money out of Venezuela, Argentina, Cypress or Greece before its gone or you can't get to it? Those are all illegal. Legality and morality are not the same thing and not all of world lives in cozy security.
Copy and paste down arrow? On mobile.
Well it would be suited to other computer vision tasks based on the hardwired accelerator cores.
I don't see it the same way. Being immortal and fertile all the time could completely change the baby-making dynamics. What if people have fewer children because they can focus on their career earlier in their lives? Were they immortal, they could start making children while they're 100 years old and settled.
I find it a bit ridiculous Carl Icahn can go on "Power Lunch" on CNBC, speak for a few minutes, and cause investors to go into a selling frenzy (not only AAPL, but the entire market NASDAQ and DOW was affected).

Securities are so easily multiplated and affected by CNBC and their interviews, it is a bit scary. Perhaps even more scary are reporters who basically write opinion pieces and affect security prices.

Looking on Carl's twitter (https://twitter.com/Carl_C_Icahn/status/725717908056330241) he even said he was going on "Power Lunch" before he did. Of course it would be hard to know what news he was going to deliver, but you have to think some people "in the know" had an idea and made some money today.
The Forgotten Lessons of the American Eugenics Movement
Sure, but that doesn't mean the criticisms are correct (or for that matter, that the compensation is correct).
e is real, e + ei is irrational.
cfn-nag – A Linting Tool for CloudFormation Templates
Compared to deep ocean, space is easy. The rocketry is tricky, but you don't need to build foot-thick steel walls and, if something goes wrong, you can go outside.

Unless you are talking about bottom as in 10 metres down. That won't protect you in case something goes seriously wrong.
Pro: Reliability/longevity (your product still works even six months later when the cloud API provider has been acqui-hired.)
> A professor of cognitive science argues that the world is nothing like the one we experience through our senses.

Actually the world -is- the world we experience through our senses. There's no "other" world. This article is full of shit. Whatever it is he calls "reality as it is" is the same reality we perceive through our cognitive functions, there is no other way to apprehend reality.
It might be slightly more complicated with the addition of tradable items such as keys, but they probably already have some sort of system to deal with it as credit card chargebacks/fraud will require the same thing.
Love him or hate him, Stallman's contributions have been instrumental in shaping the landscape of technology as we know it today. I have nothing but respect for him and the Free Software Foundation.

And now for a song, https://www.youtube.com/watch?v=9sJUDx7iEJw
Concurrent JavaScript – Intro
I call BS.
The big pieces of software you mentioned -- GCC and Emacs -- have been weakened in various ways because of RMS though. RMS' fear of proprietary programs accessing certain internals, like the AST means that GCC doesn't have the extensive plugin ability that clang does, limiting the types of code analysis and transformation that can be done [1]. He has also shown himself to make knee-jerk reactions about pieces of free software which are not under control, such as his refusal to merge in basic lldb support into Emacs' gud [2], invoking the bogeyman of Apple in doing so. In the past, he has also told people to memory hole software he personally disagreed with [3]. He has done some impressive things in software development, however, his more recent points of view have had some serious problems in dealing with the relevance of users and developers today. Stallman needs a better team of people around him to advise him on modern practices, otherwise all his efforts will go to naught as people migrate to other Free tools that better recognize and respect more recent software and social practices.

[1] https://lwn.net/Articles/629259/

[2] https://lwn.net/Articles/632773/

[3] https://gcc.gnu.org/ml/gcc/2001-02/msg00895.html
Isn't that exactly what P2P/IAP is?
> So we're in the price war stage still, not much at the differentiation stage.

Depends what you're looking for I suppose. If all you need is basic compute instances then, yes, it's a price war. Any products beyond that have a tenuous relationship between the different providers.

Even something as simple as using a columnar DB pretty much locks you into one of the providers because you have to build around all the nuances of SQL Server vs. RedShift (Postgres) vs. BigQuery.

Forget talking about things like infrastructure automation once you're trying to manage this on demand across many environments in a reproducible way.
It's not only about speed, it's also about deeply specializing templates.
To point 1. Most who don't understand bitcoin think the federal Reserve is a government agency. But these same people got (and still are) angry at the banks for their part in the great recession. If they really understood what happened in 1913 with the creation of the fed their heads would spin.

Those that understand the big picture and the threat central banks pose to a nations sovereignty, and the debt slavery of its citizens, are the ones who truly appreciate bitcoin
Really depends on where you go. In our office, we use C++11 functionality in our AVR chips.
Neither does Linus.
Which is totally orthogonal to CLOS, though.
Why Product Managers Hate Vacations
Could you clarify if you are trying to make a comparison between garbage collection and unique_ptr? Or are you saying that you wish CLOS allowed dispatch on types as well as classes (anyone know the historical reason for why this is the case?). Or are you making the point that it would be ugly to create a new class "vector-of-list-of-fixnums"? Or something else?
The problem with the Kardashev scale is that it ties the advancement of a civilization with its energy consumption.

In order to qualify as a Type III civilization, you pretty much need to harvest ALL of the energy in a galaxy.
Володя жги)
Ask HN: What do you wish someone would build?
Looking to build something really productive and useful as I invest time into learning additional technologies.

My skills are available to HN members. I'm able and willing to build pretty much anything along the lines of B2C or B2B tools (therefore excluding compilers, database engines, or operating system, and the like).

What do wish someone would build for you? The emphasis is on something that solves a practical problem for you, not just interesting.

I will select a wish that appeals to me, and give free invites to HN members when it is done.
<$100[0]

[0] http://www.tomshardware.com/news/movidius-fathom-neural-comp...
The retail business is competing with a very old, very established industry. The cloud business pretty much created a new industry.
None of your examples make sense to me.

You say "explicitly passing self is lame" and then praise Golang for "feature restraint" when it does the exact same thing.

I don't know what "pattern matching on type constructors" means. You use the constructor syntax to pattern match in Rust.

There is no such thing as "block syntax with where clause". Where clauses go on signatures, not blocks. This is also the exact same syntax as Swift, which you praise for "more refined syntax".