skysight-inc/HackerNews huggingface dataset:
You may be thinking of Richard Florida - https://en.wikipedia.org/wiki/Richard_Florida - he talked about economic megaregions in his book 'The Rise of the Creative Class'.
Yellow Fluorescent Proteins are a great example of this. Very loosely speaking, there is this open ended barrel structure that 'hides' the fluorescent part in the center. The fluorescent part in the center will glow yellow when you hit it with blue-shifted light (Stoke's Shift). You send light in, and you get less energetic light out. What makes the florescent part glow yellow in color is an interaction between neighboring molecules. How do those parts interact, like the real guts of the interaction? Quantum Mechanics. Resonance energy transfer and all that jazz, oh you know, elementary graduate level quantum classes (/sarcasm).

So when we say that the process is non-deterministic, maybe that is not quite right. Some of the processes are deterministic, in the sense that quantum mechanics is deterministic in the sense of probability density functions. Which is to say, who knows.

Yeah, molecular biology is right on the edge of being total random noise and actually making things happen. Where any one part of a spaghetti mess of interactions falls on that edge in a given temperature, ph, or salinity level, well, we could use more funding.
Up until Win7 the Win32 subsystem wasn't entirely in userland. In Vista they started the MinWin kernel initiative to extricate it but I don't know if that's full come to fruition in Windows 10.

If it has then you could theoretically write a WinNT interface for Linux and run the Win32 userland on it. But that's pretty much asking Microsoft to sue you into oblivion.

* According to Wikipedia, the MinWin project started after Server 2003 shipped.
That's not a trng
Is anyone running this in production and care to share their experiences? This seems to be a pretty good replacement for Splunk's alerting mechanisms in the ELK stack, which has always been one of the parts I miss the most.
I'm trying to understand what was going through peoples' heads for something like this to happen in the first place, but I'm drawing a blank.

Is this what mass hysteria looks like?
I tried the (or one) android app and it was fairly good, though I'm back with keepass ATM as it ultimately has the best cross-platform support (windows).
Olá!Dois novos blogs que falam sobre treinos,dieta,emagrecimento e saúde,acessem e confiram!O endereço e:

http://treinosaudeebemestar.blogspot.com

http://dietaemagrecimentoesaude.blogspot.com

DESDE JÁ,MUITO OBRIGADO!
Nah. DuPont was selling gunpowder and paint to completely different customers. Apple sells devices and services to the same customers. Furthermore what they are selling needs to be tightly integrated.
I've travelled to plenty (I used to work for a large multinational and travelled to all parts of the world) and people I interacted with across many disparate cultures made the effort to pronounce my name as I was introduced (or introduced myself) to them. I also made every effort to pronounce their names as they pronounced them. Accents being what they are, it wasn't always perfect, but they never decided to call me a local translation of "Dave."

But again, I think we should call Italy "Italia" because that's how Italians spell and pronounce it. When I ask a local something about Padua and they look at me confused until I ask them about Padova, we should all be making the effort to call it "Padova."
Just checked, it says 25$ per month?
Why so many celebrities have died in 2016
Yes, this is an issue on the Kindle device, but reading textbooks in the Kindle app on the iPad is gamechanging. The speed with which you make highlights, leave notes, and bookmark is great for learning. I can then access the book from my computer for quick reference and/or convert my booknotes to Anki flashcards.

This being said, I also own a Kindle Paperwhite and use it at least an hour a day for reading non-technical books. I can't recommend that device enough.
A mentor would be an amazing source.

Unfortunately where I work there aren't any people that would fit that bill. Finding a mentor outside of work is difficult for many reasons.

From what I've found this is a pretty common problem.
Does USA being a 4th most common place of shootings invalidate my point of trying to find a root cause instead of surveilance?
Have you list of good resources for these math topics?
I was going to post her name. Jane Jacobs wrote, among other books:

- Cities and the Wealth of Nations

- The Death and Life of Great American Cities

- The Economy of Cities

Her last book, in 2004, was ominously titled "Dark Age Ahead".

Incidentally, I worked down the street from where she lived at the time of her death (the Annex, in Toronto). Her ideas were a recurring topic at the pub, the Duke of York.
I wonder how soon until this develops https://en.wikipedia.org/wiki/Dream_Park
fascinating thought is what a well-run services Org looks like?

and how that can layer onto a hardware / device Org.. they never seem compatible
Sonos on the cheap: How Chromecast Audio breathes new life into old speakers
Services are hardly a unique Apple specific problem though. For a few that get services right you'll find many that suck. It takes a very different collective mindset, culture, processes and iterative improvements - those are a no brainer. Beyond those it also takes unconventional innovation at multiple different levels - look at how HTTP2 happened for example and look at how everything underneath GMail must have improved to make it what it is. Also think of AWS and how many first-have problems they must have needed to solve.

It's hard to get services right and even harder to keep them right. I am of course not saying Apple can't get there but merely separating the hardware and software/services isn't a meaningful first step.
Ask HN: How to develop an entrepreneurial insight?
An entrepreneur comes across a problem and develops a solution to the problem, but how does one initially find the problem? Are there certain skills one can develop that enhances problem-finding abilities?

Any books recommended?
Did you have early exercise of your options? Otherwise you may consider the tax impact of leaving the company and having to exercise. Can you afford it? Does it matter to you?
Show HN: WaspDB, encrypted key/value database for Android
I have been running this. It works well. I also wrote some custom code to send the stack-traces, if we get any, to a slack channel.
Yea good way to get cheap labor
As I mention above, I'm not so obtuse as to have a negative reaction to someone making an effort to say my name as I introduce myself, because of a non-native sound.

Different alphabets do introduce unique challenges, but across all languages using the same Roman alphabet, it's spelled D-A-V-E. (Or D-A-V-I-D if you insist.)

But then, I've never had anyone in any culture besides my high school language teacher tell me my name was something different.
They still don't save passport details, so flying outside Schengen with them is still a pain. Particularly 'transfers' through the UK.
Why couldn't/shouldn't people complain about it? It's like how you can be against paparazzi. The fact that something is legal doesn't make it morally right or immune to criticism.
IMO you should place all requests within a single ClientSession().

This will provide two benefits:

1. You won't need to use a semaphore. To limit connections you will need to create a TCPConnection() object with limit set to the limit you used in the semaphore and pass it to the ClientSession() and aiohttp will not make more connections than the limit set (default behavior is to have unlimited number of connections).

2. With single ClientSession(), aiohttp will make use of keep-alive (i.e. it will reuse same connections for next requests, but it will keep at most the limit of connections you set in TCPConnection() object).

This should improve performance further, and (given sane limit) it'll also solve issue with "Cannot assign requested address" error.

BTW: Even without limit set aiohttp will try to reduce number of connections open so it might still fix the connection error issue as long as individual requests don't take long. It's still good idea to set limit, just to be nice to the remote server.
When you think about it, factoring in earthquakes, drought, tornados, hurricanes, sea levels, floods, tsunami, forest / brush fires, landslides, avalanches, and whatever else I'm forgetting, there really isn't anywhere good to set up camp and, rightly or wrongly, once someone does set up camp, they're hesitant to move.

Either way, the situations described in the article, conservation, waste prevention, and innovation seem to be the exact opposite of that described in the Water Knife blurb, and will have the luxury of being applicable to places less arid. While California was having their record droughts, the opposite coast was experiencing flash floods.

If we can improve conservation, and dramatically improve transportation, it becomes easier to get water from places that have a surplus to places that have a deficit, which means we can push flood waters to areas with drought, and move our way up the Kardashev scale.

Edit: Forgot cold weather and volcanic activity. The cold weather sounds like something easy to disqualify, but considering the OP's assertion is that it's a bad idea to try to best nature, it seems that heating falls into that bucket.
Best moment of domestic animal
I spent a long time in the past couple of years trying to work out how to deploy secure WiFi and failed to come up with anything great. The biggest challenge is that client support for anything beyond wpa2 psk is virtually nonexistent. The Hotspot 2.0 spec is supposed to make all this easier but it's not widely supported and heavily influenced by carriers whose goals don't always align with everyone else in the space.
Flight scales badly to slow speeds. Let me demonstrate with some very rough calculations:

Imagine three aircraft flying the same distance.

The first is a large airplane flying at 20 m/s. Solar impulse speed.
The second is a large airplane flying at 200 m/s. Basic propeller plane.
The third is a small airplane flying at 200 m/s.

Slow plane:
speed: 1x
area: 1x
lift: 1x
payload: 1x
drag: 1x
thrust: 1x
power: 1x
distance: 1x
energy: 1x

Big fast plane:
speed: 10x
area: 1x
lift: 100x
payload: 100x
drag: 100x
thrust: 100x
power: 1000x
duration: 0.1x
distance: 1x
energy: 100x

Small fast plane:
speed: 10x
area: 0.01x
lift: 1x
payload: 1x
drag: 1x
thrust: 1x
power: 10x
duration: 0.1x
distance: 1x
energy: 1x

You can see that you use the same energy per payload no matter how fast you go, but your plane can be a lot smaller if you go fast.

(This didn't take into account altitude. That means you can go even faster for the same energy expenditure.)
Looks similar to a paper version of a United Mobile boarding pass:
http://pointsmilesandmartinis.boardingarea.com/wp-content/up...

Still, an improvement... I always assumed the form factor was driven by the ticket printers installed for the airport gate agents.
And yet almost anyone can implement an HTTP server with their own parser, that works for every client out there in just a few weeks, but not TCP stack or DNS server.

That has little to do with binary vs. text. It's because [1] TCP is itself a very complex protocol, especially to get all the corner cases right, and [2] DNS servers are not popular to write because there is usually very little reason to. If HTTP was a simple binary protocol you'd probably make the same observation.
I think that is really great idea! :)
You're right, and I'm sure globalization and the Internet make me more stubborn about the whole thing.
> Indeed, in gametes (sperm and egg cells) the cells use enzymes that rebuild telomeres.

Is it practical to harness this somehow to extend life then?
Discuss documents online without any software
I am unsure whether to take your comment as an example of repressed thinking, or as an oppressive attack. Please detail your anatomy so that I know whether to condescendingly "help" or to denounce you as an offensive shitlord.
Domainr API Laravel Wrapper Package
I've never worked on state-level appliances, so thank you for the information, but just for the sake of stopping urandom-fear, let me spell out why this all does not apply to the 99% of us developing for consumer processor architectures (which I'm sure you realize):

- the "uncertain mathematical constructions" are hashes. More precisely, in Linux case, SHA-1 preimage (not collision) security. No civilian cryptosystem would survive the fall of hashes.

- all other points are void as soon as you use that randomness from a regular application running on regular CPUs, as all the bit-flips, compromises and backdoors can simply happen there.

- having the keys on hardware DOES make compromise recovery much easier, but there we are speaking of HSM capable of doing the private key operations themselves, not simply providing randomness.
Normally I'd agree with you, but Facebook and other social media sites have controls to make your posts private. If you choose to make them public, you are giving your consent to have them trawled and searched by anyone and everything on the Internet. Kids aren't dumb. They can learn how to make posts private and how to limit who sees what they post. If they choose not to and their parents do not get involved, then I don't see the issue with the schools doing this.
It is also the final defense against unrestrained cell divison; a natural protection against diseases such as cancer.
or u can just Rent A Friend : http://www.afar.com/magazine/the-incredibly-true-story-of-re...
-- proven to work in japan. perhaps it could be repurposed for the US market. (although i dont think it would play out very well )
> This is a myth.

If it's a myth, how would you describe what Microsoft did to Netscape with Internet Explorer?
Austrian far-right party wins first round of presidential election
So the "safer" means more group-think and getting banned if you disagree with someone?
This is basically what I do. Whenever a cool idea comes into my head, I put it into my list app. I have a list for projects (e.g., build a piece of furniture), skills (e.g., woodworking), topics, and business ideas.

I then review these lists periodically and when the time is right, they naturally move into my "Active" list in one form or another.
Yes, I am reminded of having read the same. Was it not the first link in your post? The skill subjects had to learn was based on a mouse-like control operated by squeezing.
Blake Ross: Aphantasia- How It Feels to Be Blind in Your Mind
It's fairly difficult to find someone who cares enough to mentor you. They can't buy stock in your person, they are busy with things in their life, they don't have much power over you so they can't quite be sure to get even a short-term payoff.

It might work if the pupil is willing to just do the bidding of the master to relief him from his chores, so that the master has incentive to spend effort on pupil's education. I surmise so few students want to play this role that there is no cultural norm to draw from, the concept is too alien.

It's a pity, too. There ought to be a way to transfer knowledge and skill from one generation to another.
His book, Triumph of the City, is a good read on urban economics.
The Future of Technology Is in Your Ear
There's kind of two layers to how I think - if I'm actively thinking about something (such as writing this post, or imagine a specific event/occurrence), then it is a very defined internal monologue, and is essentially how I would speak about the topic.

If its a more passive thing (such as pondering something whilst actually working on something else), or my language 'skills' for lack of a better word are doing something else (e.g. listening to music with lyrics), then the thoughts are more abstract ideas and images, and the monologue only returns when I come to some sort of conclusion. It's interesting to note that this happens more frequently when I've been using languages other than English.

Brains definitely are weird.
Listonia – Booyaka
> Keep in mind. This is not an experiment, this is a clinical trial in a human.

(Note: I have one drug in clinical trials, for which I designed the phase I and phase II protocols, and have appeared before the FDA in support of clinical trials of new medications.)

Actually this is not a trial, it is considered an experiment. Trials are controlled (not always blinded or tasted against placebo, as many people think). Strictly speaking you cannot give an unlicensed medication without getting in trouble -- in fact permission to do a trial is actually agreement by the FDA that they won't prosecute you for breaking this law, basically because you followed one of the procedures spelled out in the law and the FDA agreed with your proposal.

You are completely right on interactions. And yes, the animals are pretty much always sac'ed at the end of the experiment, even those in placebo arms :-(

There are a few quasi-informal exceptions to the no unapproved administration. One is if you develop the drug yourself -- hard to prosecute. In a modern corporation however you can't really do that -- if you're a research scientist developing a drug, lawyers could claim that you were forced into it by your boss (another example is that the FDA requires that QC be an independent function). So in practice the only person who can try such a drug is the CEO.

In my case I was both the CEO as well as one of the developers so was confident that the in vivo data we had showed that I would be fine. As a result I was a pincushion (these were true experiments in PK, diffusion etc -- I didn't have the indication we were treating for). The drug hasn't yet gone for approval, but if it does, somewhere in the approval application there will be a description under "previous human experience".

You can do other experiments and trials someplace not subject to the FDA (i.e. other countries). Unless they are also formally part of your FDA process you can't use them in support of approval -- but if you paid for them you have to include them as previous human experience as well.

And there are also various "compassionate use" cases though they are also somewhat-formalized now because some people try to stretch them into trial territory. By definition they are not adequately powered.

There are amusing examples of previous human experience. My favorite is someone who shall go nameless who argued in support of an erectile disfunction treatment in front of his board by dropping his trousers and injecting his penis in front of them. I have only heard of this second hand but I bet there was quite a reaction!

NB for anyone else in pharma: yes I glossed a few terms like calling the NDA an "approval application" in the interest of clarity for those not in the industry.
Yes, I believe the joints were usually weak points. Swords-people used a technique known as half-handing, where they'd keep one hand on the hilt, and use the other hand to grip near the tip of the blade. That allowed them to use the sword more like a dagger, which gave better accuracy for maneuvering into the joint, while also giving them greater leverage with the hilt-hand.

I was surprised that you can grip a blade with your bare hand, but apparently it's safe with a firm enough grip.
I assume that this is far from unique to humans, but not quite universal. I wonder whether the "immortal jellyfish" turritopsis dohrnii has some telomere rebuilding mechanism for all cells that provide its age-defying abilities.

I also wonder whether there is a second advantage to telomere depletion; reducing the instances of organisms from different generations carrying the same genes competing for resources. After all, we're here for the benefit of our genes, not the other way round.
What are the problems with the new design from operational staffs perspective?

The article ends by saying they wished they had taken operational staffs opinion into account, but there are no examples with things this does worse than the old.
You could just print it in black in white. None of the colors convey important information.
Ask HN: Books to learn advanced C programming
Hello,

I've recently been doing a lot of systems programming and low-level stuff. I'm hacking away on MIT's xv6 kernel for my OS course. I want to improve my C skills, and want to learn the limits of what can be done with C, the preprocessor etc. I'd be really grateful if some one could direct me to resources that would help me out in this regard.

I want to basically learn how to write robust, readable and production-quality C which doesn't crash to a segfault.

Also, is there a oft-used style guide for writing error-handling code in C?

Thank you.
Here is a more recent history of Interix and the history of it, from Stephen Walli who was part of it:

https://medium.com/@stephenrwalli/running-linux-apps-on-wind...

https://medium.com/@stephenrwalli/running-linux-apps-on-wind...
If someone had the secret to eternal life would they break it on hacker news?
having contacts online isn't really the same thing as a "friend", right?
No personal armor (so far) is good against blunt trauma. The reason for that is conservation of momentum. Blunt weapons often rely on large amount of momentum. Only thing you can do is to make the armor bouncy. So you can try to turn it into elastic collision.

https://en.wikipedia.org/wiki/Elastic_collision

But then again they often added small spikes and rough surfaces to the tips of such weapons, to turn it into inelastic collision.
http://www.medievalcollectibles.com/images/Product/large/AH-...
https://en.wikipedia.org/wiki/Inelastic_collision

The bad shit for the weapon is that it's very difficult to change the direction of war-hammer mid course. So it's easier to block.

Kevlar makes armor of similar effectiveness lighter. But there is nothing fundamentally better than old plate armors. It's still just distributing force to larger area. With penetrating weapons this is potentially very effective, as there is relatively little momentum and energy. The idea is to have very high local pressure at the tip of the weapon and this normally cuts deep into flesh.
Battlefleet Gothic: Armada – Launch Trailer
Luckily for him it's unlikely bike thieves are reading the guardian or, I hope, HN.
Dupe: https://news.ycombinator.com/item?id=11554894
Apple and others would be smart to diversify their manufacturing capabilities to other countries.
I have definitely experienced this, but till now hadn't had the words to describe it. Thank you stranger!
I think defaults are necessary when someone is not logged in. When an account is created, suggestions are given based on interest, such as it is with meetup.com - News, politics, sports, local, tech, animals, humor, etc. are recommended in their own categories, and people sub as desired.
Always Google, which leads me to Wikipedia. Almost literally every time...
> This inefficient use of volume is probably a more severe limiting factor than the weight.

I don't necessarily disagree with you. However, weight is a really, really big deal in aircraft. And the volume becomes less of an issue as aircraft get bigger, thanks to the square-cube law. Are modern day jet aircraft big enough to largely offset the costs of fueling them with liquid hydrogen? I don't know, but they're pretty damn big.
Telomeres shorten because we have linear chromosomes and it is physically impossible to replicate them without losing a bit off the ends (because in order to extend strand 1, you need to template off strand 2, so the end of strand 2 can't be copied).

The telomere is a solution to this problem; you just pad the ends of your chromosomes with useless repetitive sequence so if you do lose a bit while replicating it doesn't matter. Any anti tumor properties of this system are an ancillary benefit.
Paparazzi ambush people going on with their daily lives - they have no choice but to venture outside (into public places) sometime. That's hardly the same as deliberately publishing something on a public network.

That said, sure, you can complain about it. I guess I just don't see the point.