skysight-inc/HackerNews huggingface dataset:
Clinical Trials without barriers
Clinical trials are essential for a drug to get approved by US Food and Drug Administration. One big obstacle for clinical trials is to enroll the right category of patients in a timely fashion. For some rare diseases, it is challenging to find enough patients for the clinical trials in a short period time in the US, while large population of patients outside the US look for clinical trials as their last resort of treatment, but they don’t have a channel to access the most current clinical trial information due to the protocol complexity and language barrier. We aim to find a solution to connect the patients both inside and outside the US to the clinical trials. We’ll digest the vast clinical trial documents and generate a user-friendly web interface that the patients can easily find clinical trials that match their diseases conditions. Patients then can further contact the doctors or hospitals to inquiry more details about the trials. We’ll also provide service for patients to communicate with doctors and go through legal documents for patient registration. We believe that we’ll help to break down the barriers between clinical trials and the patients, particularly the patients outside the US.
Our team consist of an accomplished medical scientist, two software engineers with expertise in backend and frontend.
My biggest issue with guns is that they let one person become judge, jury and executioner without due process. Yes, you can kill someone in many other ways but guns have a tendency to deliver multiple kills with incredible ease and detachment.

I do understand that rural areas are going to need a level of protection from wild animals that might not be required in urban areas.

My suggestion for how to solve gun violence is to put together an "Apollo moonshot" project to develop a non-lethal weapon as effective at stopping as a lethal one. Phasers on stun is my dream. Once you can stop a person without harming them you can then take a tobacco industry marketing campaign to make owning a lethal weapon unacceptable in civil society. Rifles and relevant lethal weapons should still be available outside of urban areas unless non-lethal alternatives would work.
The fact that console is logging from xfrom y on the same line means both executed at the same time?
I'm not sure I've ever seen a story marked "minor". Generaly the "priority" of these things is just based on how annoyed the person filing the story was at the time.
Scrum/Agile-English Dictionary. https://reddragdiva.dreamwidth.org/594955.html
Does that apply to the rest of the Bill of Rights, or just the right to bear arms?
It's too big to be considered a tablet and its definitely not a laptop. It is definitely meant to go on a desk. I can't imagine trying to use a small LCD TV in my lap the same way I can use a tablet or laptop.
It's maybe useful not to confuse specific criticisms of HubSpot with more general criticisms of the culty stage-managed hyper-enthusiasm that surrounds startup culture in general.

Just because someone is earning $150k doesn't mean they're not being sweated and exploited. To its owner, an expensive machine is still just a machine, and not an equal partner.

The tell is always the quality and genuineness of the relationships between employees and owners. It's completely possible for owners to take a genuine interest in the welfare of employees, and to see them as colleagues instead of productive units to be sweated.

But this may not happen as much as it should. And the boilerplate puppies-on-adderall always-crushing-it change-the-world so-very-excited incredible-journey rhetoric turns out to be an excellent smoke screen for owners who have no interest in anything except personal gain - and aren't even slightly concerned if they leave a trail of human wreckage behind them.

And even if you start off wanting to be a humane founder, there's no guarantee investors will let you run your company like that.

So it's easy to criticise Lyons for playing to the gallery with his book. But that doesn't mean that what he's playing is an improvised fiction.
I'll admit I haven't and won't read the article. I would bother if it didn't really bother me. I'll reply to the essay in itself that is the title. Really, people favor black and white because of distrust. They don't trust others, or even themselves, with what they evaluate as slippery slopes. Maybe you need to differentiate. Maybe you can exercise good judgment and know when what. People, in practice, do this. They'll never hit a person who has good reason to be physically weak, unless the unthinkable and only reactable happens and that person starts aggressing their child. And boom, hard and fast describes the response, not the rules followed. And it doesn't count, and they don't feel guilty. But talking about this is difficult.

Also, look at it from the perspective of debt. The concept and many realities of debt permeate everything in modern life, especially morality. Black and white is really red and black: what I mean is that the concepts of evil and good :: heaven and hell :: serving and receiving interest are linked. Spending leads to debt / Serving yourself is evil: in death, you'll fall to hell, which is nothing other than payment for an unpayable debt that compounds faster than one can serve it. And heaven is not only the opposite, but the counterpart too: you have so many debtors paying you interest for all your good done or goods sold you are living off the interest.
I believe that people should not participate in a discussion on critical issues if unable to completely comprehend relevant information, for whatever reasons, be it lack of general knowledge, or poor language skills, or something else.
Panasonic says it created a weather forecast model that beats the European
We have finally come a full circle. Agile UML and IBM Rational Scrum are just around the corner
There may well be plenty. There are probably also a lot of people, like myself, with no connection to HubSpot who dislike Lyons's latest writing.

Having read a few of the promotional articles for the book, I'm certainly not a fan. He seems like he went looking for the worst and is generalizing as broadly as possible to create a sensation. A publicly traded email marketing company founded by a couple of MBAs in Boston 10 years ago doesn't really represent all of Silicon Valley startup culture.

Lyons does touch on some genuine problems. But he doesn't seem to approach ageism or problematic work cultures with much thoughtfulness, and he isn't contributing much to the conversation.

At the same time, HubSpot doesn't seem like a great place to work. In fact it seems like they have (or have recently had) some serious issues they need to sort out.
Unsurprisingly, it appears that the "BizBook 1"[0] is a re-badged Taiwanese Clevo W740SU[1] which was also sold as the System76 Galago Ultra Pro[2]

And why is it so hard to find pictures of old Clevo laptops on vendor sites? Not even support pages. :-/

[0] http://bluesonic.af/en/product/bizbook-1-af-40su-gallery/

[1] http://www.anandtech.com/show/7182/90-minutes-with-the-clevo...

[2] https://system76.com/static/images/support/guides/galu1-quic...
There's one giant issue with that. Most gun use isn't with intent to harm another individual.
What's broken about the logic? All of those things are logically consistent.

If you mean that foregoing experiences for safety's sake isn't your cup of tea, that's one thing; but claiming it's logically broken is simply false.
And very specifically, if "smart" handgun technology is developed, sale of all others will become illegal in New Jersey: https://en.wikipedia.org/wiki/New_Jersey_Childproof_Handgun_... Of course "a seven-member commission [would] determine whether personalized handguns qualify for use by State and local law enforcement officers", all these sorts of laws have such exceptions.

And such as been proposed in California and Maryland. It's not "paranoia" when they are explicitly "out to get you".
2012 is latest release. Need to put (2012) in title, I think.
This article notes that Colt had fallen on "Hard Times". This is an understatement.

In the mid eighties, Colt was doing great, making hundreds of thousands of rifle for the US military. Then a five year labor strike brought the end of all military contracts as Colt replacement workers were unable to make properly functioning guns.

Colt decided to focus on the civilian market, and brought out a new high tech handgun that was so unreliable that it was eventually recalled.

Then Colt's CEO said that he was in favor of a all gun purchasers having to register federally and purchase a federal permit and training. This did not go over well. (*understatement)

His replacement, seeing that the military would not buy Colt guns and that civilians would not buy Colt guns, decided to focus on police sales.

Unfortunately making a new smart gun required ability in the two things that Colt was not good at - making reliable guns and designing new guns.

It was not just the disastrous demo that killed the smart gun - the prototype smart guns were not even able to be fired without permanent destroying the mechanism. Also, there was a delay from between when the gun was grabbed by the officer and when it could be fired. And of course, the fact that it didn't always unlock to fire even in the best possible circumstances.

Interestingly enough, police handguns have moved even farther away from the smart pistol idea. Today it's a rare department now days that does not use Glocks or M&Ps, both of which are far simpler than the average police handgun of the nineties.
Yeah, they're all executing on different cores.
In the graphic it's worded as "88.8 per 100 people" which can easily be mistaken for 88.8% because it doesn't state that it's 88.8 firearms, not 88.8 people.
Will companies using this be able to:
1) implement their own algorithms?
2) retain exclusive ownership of their data?
3) host your platform locally?
If you want React Native, then you need React :)

From what i gather, React Native is good enough for simple things and is iOS-first, but quickly fails to live up to the hype for anything moderately complicated and is actually slower than apps that are native from the get-go. I'm not sure if this is still the case, but aiming for the lowest common denominator seems like a lot to give up.

I would be interested to see a React Native app that truly benefits from being native, aside from the app store and distribution aspect.
Honestly, early on in a startup it is rare to have such specialization. That usually happens later. Usually early on you have 1-2-3 jack of all trades that can and are willing to do whatever so the chances loosing one causes that kind of disruption is rare. Although it is not unheard of, and if so, there are ways to manage. As others already said, you first counter with reasonable offers but only as a means to replace the person, as let's be totally honest, a founder shouldn't consider this a long term resolution as the employee already showed they want to leave so expect they will want to leave in the relatively near future too.

Outside of this, funded startups many times turn to advisors and investors to help them find a qualified candidate. And when not possible they may use a recruiter to find a person. For all the shit recruiters take, they have a place in the market, otherwise they wouldn't be there.
It's just the Peter Principle in action. It long predates startup culture.
> As usual, RMS is content to sit back and complain rather than take action to try to effect positive change.

Apart from inventing your world, RMS also has the absolutely unforgivable habit of being right about things. This is what really pisses people off about him. (see also: Theo deRaadt)
I interned at HubSpot while Lyons was there. Theres some truth to this, but it's greatly exaggerated.

"Frat house": Like many companies, HubSpot often provided alcohol and would host parties for big events. As for personality types, the engineers I worked with were pretty typical engineer types.

"Kindergarden": HubSpot has a big intern/co-op program, and likes to hire former interns as full-time. I can imagine Lyons might feel a bit out of place with so many young people.

"Scientology": The company didn't feel much more cult-y than other young software companies. I'd describe the culture as "We work hard, build products customers love, and treat our employees well".

For what it's worth, I really enjoyed my time at HubSpot and have only good things to say about the people I worked with. However, I was an engineer, and can't speak to the marketing team that Lyons was a part of.
I wonder if criminals like muggers would be less likely to surrender if they knew that their lives were not on the line.

I wonder if this would create a risk asymmetry between people breaking the law and people obeying the law.
The powers not delegated to the United States by the Constitution, nor prohibited by it to the States, are reserved to the States respectively, or to the people.
Most of my guy friends really like cars.
They know good amounts about different parts of the cars.

I've never enjoyed reading about them. So, I've never tried learning much about them. It also takes alot of time.

I wish there were more of these type of animated illustration. I've scanned it for a few minutes and I grasped the concept it was trying to show me relatively faster than anything I've ever encountered.
Open Source includes BSD style licenses, which allow distribution in binary form only. Free Software doesn't, that's the difference and I think that difference is large enough to make them not synonyms.
My interest is certainly peaked about the 10% off coupons.
I wouldn't pose this as an either/or. MOOCs, as we know them today, are the next step in the evolution of online education.
Sprawl is everywhere. Even in Japan
I actually think it should be national, but reforms should be evidence based.

First off, gun homicides are actually down over 50% since the early 90s. There are still too many, of course.

Assault weapons bans are ineffective, since they account for 2% of crimes.

Open carry and concealed carry are emotional issues, but aren't a big contributor to guns deaths. 13M people are already permitted to concealed carry, and while it has led to more aggravated assaults with guns, it hasn't been a big increase.

Background checks and waiting periods actually do make sense. People with a restraining order shouldn't be able to get guns - research indicates that keeping guns out of their hands would reduce this category of murders by 10%.

Most of this is cribbed from Nicholas Kristof:

http://www.nytimes.com/2016/01/17/opinion/sunday/some-inconv...
When it says that it is difficult to implement the server correctly, I think it's an immediate red flag. We went through this with HTTP (nginx retrying non-idempotent requests anyone), and SMTP. I think the lesson learned that any future protocols should require really good specs and every implementation should follow them.
Another good interview, on Recode Media: http://recode.net/podcasts/from-fake-steve-jobs-to-hbos-sili...
G5 Clock
> the main factor that appears to cause all types of burnout is negative emotions

Interesting. Does that mean that from just working extremely hard, you can never (very likely) get a burnout? That would be big news.

By the way, I've heard that sleeping a lot (like 10 hours per night minimum) helps with burnout; not sure if it is universally true.
Also, they asked if they were interpreting that correctly. If you're not American, you probably don't have an intuitive sense for how common guns are. Best I can find about 30% of households have a gun. There also seems to be a pretty wide disparity about where those households are. Mother Jones, so maybe not an ubiased source of information: http://www.motherjones.com/files/gun-ownership-map-updated.p...
Thanks for the link!
Mr DeRaadt should clearly think about starting a therapy.
Lastly, I am more than childish to complain NTCIR and refuse submit a paper, I give up putting unworthy and duplicated effort on implementing a MathML parser that generates the expression tree I need (this step is the most difficult, rather than just parsing XML), instead, focusing on finding another conference to publish my efforts, it turns out my paper (a demo) get accepted in ECIR 2016, so glad I did not waste too much time on NTCIR, otherwise I would have missed ECIR.
Lazy image loader designed to enforce progressive enhancement and valid HTML
I thought this was going to be about efficient overflow checking at a USER level. I want to be able to write efficient code something like

bool SafeAddInts(int a, int b, int* out) {
if (willOverFlowAdd(a,b)) {
return false;
}
*out = a + b;
return true;
}

Or better

bool SafeAddInts(int a, int b, int* out) {
int temp = a + b;
if (magicCheckProcessorFlagsForOverflow()) {
return false;
}
*out = temp;
return true;
}

Or something along those lines.

It's all great the compiler can maybe generate code that crashes my program there's overflow but what's the efficient case for handling it at a user level given that overflow is undefined in the general case given the result is undefined?
> Of course you'd do it again, the party was fun and the cleanup team pays someone else.

Wow. I don't know how you expect that to contribute to the conversation. Maybe your goal is just to shut it down? Don't be a dick.
Interesting article, but this has nothing to do with startups. This is simply the new equilibrium in the job market. Employees have lost power. Unless you guys unionize or something, it'll only get worse from here...
After loathing make for decades and doing my best never to waste any time thinking about it, I spent a week digging in hard and learning it in detail, as though it were a programming language I actually wanted to use. It turned out to be just as terrible as I always thought it was, and I really don't want to use it - but I learned how to make it do the straightforward thing I have always wanted it to do, which I have often fumed and sputtered and groused at it for not doing, and I wrapped that knowledge up in a set of recipes which I now copy into every project I work on. This lets me take advantage of make's ubiquity without having to remember and worry about all of its odd awful corners.

Here are the recipes, most recent version:
https://github.com/marssaxman/ozette/blob/master/srctree.mk

And this is an example of a makefile using those recipes:
https://github.com/marssaxman/ozette/blob/master/Makefile
> The "Go" compiler does this

Really? I was under the impression the Go compiler did only simplistic optimisations, to get their wonderfully fast compile times. Do you have a source (e.g. the source)?
They needed to find some evidence of their conclusion? /cynic
The problem with this is that people aren't planted to the ground. Chicago has tough firearm laws but it's not that hard to drive to Indiana to buy a gun which is why Chicago has such a problem with gun violence.
14th Amendment, states can't screw with the Bill of Rights. See McDonald v. Chicago.
If they did it for the sake of this challenge then it is an added risk imo, so yes (the real alternative is no human operated traffic at all). Some people believe a controlled car hack on a highway is safe, or at least not substantially more dangerous than everyday highway business, some car just break down on the commute.
Yes its not racism. I don't know why so many people on here assume so. They prefer to believe what a Michael Moore tells them instead of viewing cities, groups as complex as they actually are.
No it's not, it is perfectly self-evident that you eliminate all risks involved in doing a thing by not doing it. I'll grant you that this is an boring and unhelpful way of minimising risk, but not an invalid one.
It can only be a national issue. As long as the answer is "I'll just go over there and buy a gun" no meaningful gun control can possibly exist. See what's going on in Chicago currently to see this dynamic in action.
Temperance movement? It's easy to brew your own beer and not that easy to machine the parts for your own gun.
Richard Stallman: Ubuntu is spyware
> "Always" was always more important than "never"

That's exactly the opposite of what you want from a nuclear trigger system. I mean if you actually need to launch, it's already past the point where it's going to do anything helpful. What you need is something that everyone in the world unquestioningly believes will always work, even if that isn't entirely true.

OTOH, if it ever goes off by mistake, that not good. Not good at all.
They're up to 1.1 years now? Wow! They were at six months for developers for most of the time I was working there (2006-2010). At three years, I was in the top 25% of seniority ("old farts").

By comparison, Overstock.com averaged five years for developers between 2010-2013.
Something similar has already happened with "microstamping", a neigh-mythical technology that would imprint the gun's serial number on all ejected casings. California has a roster of "safe" handguns which are all that may be sold by dealers in the state. However, they haven't allowed any manufacturer to add a new semiautomatic handgun without microstamping technology, which practically means that there are no new pistols being added to the list. Once the old ones fall off the list, that'll be it - it will be impossible to buy a semiautomatic handgun from a dealer in California.
I think now branch prediction on processors can go either way, just as long as it's biased one way or another. If it's not biased one way or another, try to reduce out branches into vectorizable instructions (or pray that GCC takes care of it for you).

Branch prediction isn't a GCC thing, it's a processor thing.

Observe this wonderful Stack Overflow question: http://stackoverflow.com/questions/11227809/why-is-processin...
Really? Where do you live that you are at high risk of home intrusion? Post the statistics for your ZIP code.
I do understand that rural areas are going to need a level of protection from wild animals that might not be required in urban areas.

How do people living in rural areas with strong gun control even survive?
it's really hard maintaining this discussion, as your responses keep dragging in things that have nothing to do with what I said. I have nothing against science, modern agriculture, selective breeding, basic packing and cleaning techniques, etc.

And calling "rule of thumb" black and white indicates that you aren't familiar with the typical usage of the term, which is the opposite of "black and white".

If you can't conceive of the concept of processing as being a spectrum of more or less transformation of the initial food item, then there isn't any reason to further this discussion. If you think that cleaning lettuce is the same as using a bioreactor to change the chemical structure of a food, you are just plain wrong.
This is one of the most delightful things I've seen come out of the tech satire world. It's not snarky or mean, it's not painting a target on anyone, it's just really meaningful and well done. I'll definitely send these to my team, I think they're really accessible stories about common problems in tech culture. Please keep writing them!
> develop a non-lethal weapon as effective at stopping as a lethal one

Expect that thing to be fired indiscriminately and very often by people who want to commit crimes or pull pranks, but aren't hard enough to kill.

We'd see many orders of magnitude more crimes like burglary and carjacking committed if that weapon existed.