skysight-inc/HackerNews huggingface dataset:
What other controls do you expect to see? Dataset S1 seems complete to me. There is a similar background level of indels both at the CXCR4 site and off-target 1 and off-target 2 sites. The experiment increases indels at the CXCR4 site, but not at the off-target sites.
Slightly off topic, but I find the fascination with ASCII-arting things interesting.

I grew up in the days of 2400 baud modems and even ran a BBS briefly. At the time, ASCII art was the only thing you could do to differentiate yourself.

Nowadays I suppose it's a combination of nostalgia and ease of transferring since pretty much every system ever has a way of reading ASCII.

But I wonder how long the trend will last -- the majority of internet users don't have "nostalgia" for ASCII anymore [0] and there are at least a few image and video formats that are becoming almost as ubiquitous as ASCII readers.

[0] I was recently on a discussion with some folks I used to work with at university about how our old workplace was no longer offering shell accounts to the students because they weren't being used. This made us all sad since most of us learned all of our command line foo at that workplace.
https://www.reddit.com/r/im14andthisisdeep
Apple already refused to use LGPL v2 stuff. They refused to use anything (L)GPL in the past and now they continue to refuse to use anything (L)GPL. Apple is not a useful data point about what has changed, because they have not changed position based on v2 vs v3.
Google cache: http://webcache.googleusercontent.com/search?q=cache:1yasoTn...
This is already a problem for lots of other things, so it is not unique. I worked in a oil service company in Norway and we always had a lot of crap to deal with to make sure nothing when we sold our software to Iran, no American was in any way involved in that process. That is difficult when you all work in an office with people from lots of places, and you are used to sharing information and working together and suddenly you have to be conscious about the citizenship of some of your colleagues.

There are already a myriad of national difference you have to deal with, accounting rules, rules on corruption and bribes, which country has which patents etc. Privacy just seems like any other item on that list.
> One gives up a lot of freedom to be an employee.

As an employee I can walk away from my job any time I want and just get another. If I had my own business that would be way harder.

Because of that I feel actually more free and independent as an employee. You just need to make sure to have a good financial buffer so that losing/switching a job won't hurt very much. Then your employer also can't pressure you too much.
JQuery took this "best practice" to it's extreme, and we learned 2-way data binding is bad.

React enforces 1-way data binding and renders everything in one clean pass (HTML/CSS/JS).
I'd be very interested in this type of book. I've been looking for some sort of community or forum discussion or even just the right term to google for ideas on better digital organization, and either I'm using the wrong term or the information isn't really out there.

I've even been tempted to read some books on library science to come up with ideas for organization, taxonomies, etc, but I haven't done it yet.

I have an idea for a small app that would help in sorting digital files easier (kind of like symlinks to a bunch of disparate folders based on context, with drag and drop support), just to make my own sorting process easier, but I haven't really sat down to work on it yet.
There's a huge gap between the scientific breakthrough and the work needed to create a safe and effective therapy. It's not academically interesting, and academic scientists won't do it. It's optimization, not discovery. And what about the cost of the clinical trial, which could be $500m?

Government funded research institutions will continue to provide BREAKTHROUGHS to receive funding.
Show HN: Dry, a Docker container manager for the shell
Thanks for starting Mercurial.
Show HN: Bypass, a chrome extension to read articles behind paywalls
The article itself is also slathered with political paint and narrative. IMO, if you consider the comments to this article off-topic, I believe the article itself is as well.
I do the same thing but into multiple folders with a unionfs in read-only mode so I don't accidentally modify the files and cause them to be re-downloaded
My wife and I recently finished an introductory auto mechanics class — which was an incredibly fun time and an excellent experience — and one of the recurring themes of the class was just how miserable, unreliable, and dangerous cars were ~50 years ago. This video is a good example of that; it's not just mileage or seat belts or airbags, it's everything from tires to engines to brakes.
Customers gotta be alive to buy again. Its just good for business.
To make it work i think the client should have some hard drive space allocated for the purpose of "preservation" , which he can automatically use according to some reasonable policy(maybe only files i downloaded can be put in the folder) and it should allocate some share of my bandwidth for that purpose. Than the client automatically manages everything with coordination from the network.

That's the only way this can scale for regular users, i think. And of course it may use social mechanisms like feedback "you're the reason why this rare work of art if available for everyone".

As for scalability of TCP connections , you're probably right, not my area of expertise , but once this will be declared as an important BT problem with great practical value, i'm sure some researchers would be happy to contribute and might solve this.
They can't (currently) and this is why they are being suckered. 1099 has always been different than being a W2 employee. They should be being paid more to cover the differences of being an independent contractor for the same work, but they choose to forego out of their own volition and are now complaining about it.
My feeling is that they want a guide up now from the beginning before they proceed with creating Swift apps.

With Swift now open source and is an increasingly popular language to write brand new apps on Apple's platforms which consistent of iOS, OS X, watchOS, and tvOS.
Composers and audiences
99% of your food contains a trans-gene, put there by someone like me.
I would guess that no matter how you slice and dice it 50% of the time a doctor spend on reporting is 50% too much. The same goes for other types of caregivers btw.

Of course there needs to be a control system but the problem with NPM is that it puts optimization over outcome and because getting the data is the only way they know how to optimize it basically ends up being the goal justifying the means.

This has created layer upon layer of highly paid middle managers and is basically right now crippling the Danish healthcare system.

It used to be one of the best in the world but have slipped down to 36 now.
The algorithm dosent need to be too complex. You basically look at each still frame as grayscale, generate a hashtable of brightness values mapping to monospaced characters, and convert each grayscale pixel to a character.
CRISPR is a mechanism by which some species of bacteria and archea can edit a virus out of their genome -- it's essentially a small immune system. CRISPR is "hot" right now because of the potential to use it to edit arbitrary genomes. Bear in mind that the technique has a long way to go. It's more or less impossible to do it right now without causing a lot of side effects elsewhere in the genome.

As with most science, this has taken a long time and been the result of work by many, many scientists. Some scientists have big egos and are fighting about who the "real genius" is. Furthermore, it's widely thought that there's going to be a lot of money in this technique, if you can get a patent on it.

TL;DR; cool and potentially very useful science happened, now big egos, big greed, and people who would rather get rich and win a Nobel prize than share the discovery and its benefits with the world are having a fight about it.
You start with being ethical. In the online business, that pretty much covers most things with the exception of VAT, the clusterfuck known as "intellectual property", and the fine line between freedom of speech and hate speech. (I'm ignoring doing business in repressive regimes, because there you've only got yourself to blame.)

The only reason why US companies are in trouble in Europe is because they use unethical practices that happen to still be legal in the US.

However, it was pretty obvious up front that those practices are unethical and illegal in most of the Western world.

So please, stop whining about the complexities of international businesses when the root cause is simply a lack of basic decency.
You may be interested in the NaPTAN (National Public Transport Access Nodes) data which is available for free from https://data.gov.uk/dataset/naptan and will give you lat/long coordinates among other things for every public transport station/stop in Great Britain.

"There is a NaPTAN record for every bus stop, railway station, airport, ferry terminal etc. in England, Scotland and Wales. Record attributes include co-ordinates (OSGR and Lat-Long)..."
When is a private cloud the right choice?
According to that graph, fatalities per mile were halved from 1970 to 2000. That's not a small thing!
I'm not being pedantic. libstdc++ was mentioned. That always can break.

The ABI between g++ transitions is also platform and architecture dependent. Mac was PowerPC back then. Sun used Sparc. Not everything is always x86, even on Linux.
There is no discernible gap on my wife's side of the family... they are Colombian. Further, the volume tends to increase (rapidly) as they speak over one another. I am surprised to find they are actually communicating with understanding.
No pre-existing cells have the mutation at the site you're trying to engineer. It just doesn't happen. Otherwise selection alone would be good enough. But mice cells don't have that much intrinsic variation. Plus a lot of time they're inserting whole genes or larger payloads. The statistical probability of that arising from chance is zero.
The 'Almost' part of blocking anything is because it won't block its own ads.

Apparently the goal is to become the new ad dealer in the block?
I'm a reader and get the majority of my information from text on a screen. I can learn things very quickly using this method (much faster than any other method).

A friend of mine needs to hear it or see it. He gets bored reading anything longer than a few pages and can't stay motivated very long using my methods.

We clearly have different methods that work for us.
Also Banting, the discoverer of insulin (or at least its potential to treat diabetes).
Investment Returns by Allocation
Ha, nice writeup. It looks like it was well organized campaign to launch app, they did everything right, yet even with all this 'cheating' involved, it is genuinely hard to make a successful app.

Plus this is area that is crowded with apps and probably not the best place to focus your efforts.
I like how they added the detail of the fuzzy dice for the older car.
It's an honorable thing you are doing helping your wife out with severe depression. I myself suffer from anxiety disorder and depression and it is difficult to make others understand my plight. The requirements for taking care of a special-needs child are equally challenging I'm sure.
if by "Warner Bros. is not known to go after this type of fan-art" you mean "Warner Bros went after someone extremely aggressively for this type of fan-art" https://en.wikipedia.org/wiki/Wizard_People,_Dear_Reader#Pre....
Agreed. I skipped over the author portion of the header because I was fixated on how good the game looked visually.

Reading through the description, I had intended to come back to HN and comment on how rich and contextual the game's introduction was. That Medium post was a story, with actual history and soul, and I was amazed by it from start to finish.

I was busy marveling at how great that introduction was, and wondered whether or not it was a generational thing, that we get 140-character introductions for most products today... Then I came here, scanned to see if there was a comment enough like the one I intended that I didn't need to post, and found the comments you mentioned.

So, to me, it looks like a great game, and without actually getting the app, the execution looks solid as well. It sounds like there was quite a bit of iteration on the project, and if he paid a team to build it, I don't know if it will reach profitability ever, but kudos to the man who, at 84, decides that there must be an app badly enough that he takes it upon himself to see it being built... whomever he happens to be.
The Real Legacy of Steve Jobs
> their key mission is to grow the value of the company, rather than do anything novel.

Well, from an investor's perspective, doing anything novel is fraught with risk, and growing the value of the company is what feeds my ROI. If there is a way to grow the value without taking that risk, they ought to do it. Be novel only when necessary.
Please stop creating a new account for every comment or two that you post. HN threads are supposed to be conversations. People have conversations with other people, not random-access snippets.

HN allows anonymity and trusts users to make good use of it. This is not a good use of it. If everyone used HN this way, we wouldn't have usernames at all—just comments without authors. That would be a completely different site.
This is true, but as others stated an over-simplification of Twitter's features. Even without the factor of scale, building Twitter for 1000 users would be hard when you consider things like private messages, e-mail notifications, on-site notifications, hash tags, retweets, favoriting, follower-lists, url shorteners, images / videos, ads, analytics, search, security, new features like their 'moments' tab, - and considering how all of these features work together on mobile as well as web. THEN start thinking about scale and how these features work together - not just the C and R of CRUD, but the U and D too.
One of two possible interfaces (command line vs not command line) The context is that their command line interface is billed as an alternative to IM.
The inventions of scientists in academia, like employees in the private sector, are owned by their employers. Universities and research institutes typically have a policy to profit from these inventions via patents in order to fund more research.

The people that need to change this are at the administrative level: laws via congress, and then chancellors of universities.
I'm definitely intending to try writing a Doom clone when 5.7 comes out - thats when the QML Compiler is open sourced, and thats the first iteration after Qt3D is API stable, so it should be fun to work with.

I'm just curious of how much force multiplier you can get writing the menus with QML and the game with Qt3d.
When you start describing midsize family sedans as 'small cars' you cross the line into clickbait.
That's a very cynical and inaccurate appraisal of "The Time Before Patents."

Most scientific breakthroughs throughout history were pursued due to simple curiosity or necessity, precisely because without an international framework of patent law "patents" and the pursuit of technology as intellectual property directly for financial gain was impossible.

The British for example attempted to control physical access to textile IP but Samuel Slater[1] memorized as much as he could and "exported it" along with himself to the Americas to reap a fortune.

[1]https://en.wikipedia.org/wiki/Samuel_Slater
I won't disagree with your final sentence, but

>increasingly safety obsessed and jammed more and more expensive and heavy safety technology

Is not a bad thing. Deaths from driving are bad and we should try and reduce them, whether via legal, social, or engineering means. To say the returns are diminishing says more about how little people drove in the past and how horrifically dangerous driving was.
HN has a hug of death now? Man, this place is turning into reddit... ducks
Fermi paradox resolved: near-universal early extinction?
For longer than our twenty years of marriage, my beloved has been in healthcare...I of course have not.

My gut tells me that standardization of what is and isn't billable solves a bigger problem than described in the above comment. My whole being tells me that changing the definition of billable time won't fix crappy workplaces run by bean counters.

And if I had to guess, classifying documentation as treatment is unlikely to improve patient care and outcomes.
Making the point that views of Stalin and Churchill are quite far apart from each other despite similar actions. Churchill denied food aid from other allied countries that wanted to feed the starving in Bengal. His role went beyond prioritizing his country over the colonies; he actively prevented the Indians from being helped. http://content.time.com/time/magazine/article/0,9171,2031992...

The point you're making is that they can't be compared because Stalin killed more people? I suppose there is a minimum number in millions that must die to be considered a terrible person?

You should read up on the relish Churchill took in killing "savages". Read Late Victorian Holocausts too.
SV famously values "execution". A combination of finding the right market (slightly more complicated than just pumping money into marketing) and staying doggedly focussed.

Sometimes if you focus on the wrong thing, you die (and get made fun of). The press coverage the author seems to have such an issue with is famously fickle.

Make an electric car that looks like a toaster and a fish and market it to the general consumer. You die.
Make an electric car that looks like a luxury sedan and market it to the top end of the market. You become Tesla.

Obviously, in the latter case he backed up that market selection with world class engineering. The two then get inextricably linked. You have to look past the predilections of the establishment to get there though.
A linear scale for a graph like that is terribly misleading. The graph looks almost flat lately, but that's just because it's relatively near zero. Blow that section up to give it some vertical room and it will tell a different story.

Edit: just to put some actual numbers on this, Wikipedia says that deaths per 100 million vehicle miles in the US was 1.07 in 2014, and 1.44 in 2004. That's an improvement of 25% in just the past ten years. You only have to go back 25 years to reach a fatality rate double that of 2014.
I think we typically already know how we are going to respond to the earlier section(s) of the other person's dialog, and this is why our response is ready so quickly. If your counterpart speaks 3 sentences, I suspect that in many cases, your response really only takes into account their first and maybe the second sentence. Their third sentence likely often adds extraneous details that don't require you to adjust your response. Or, in the case of debating (ie: your response is a rebuttal in an argument), we often largely ignore what the other person has said and ramble off a response that doesn't even address the new information given to us by the other party. I find a lot of conversations to be more like two separate one-sided discussions where each person is selfishly just pushing their own talking points, rather than wrapping the other party entirely within the discussion.

Unfortunately, something about my wiring doesn't seem to match these timing cues up with my peers. In a group discussion involving three or more people, I'm desynchronized from the others. Far too often when I begin to speak, I get pre-emptively cut off by someone else who "beats me" to the cue. I think I take a little more time to plan what to say before I open my mouth, whereas my peers are ready to ramble unpolished responses the moment someone else stops speaking. Too many people just like to hear themselves talk and be the centre of attention the millisecond someone else's moment in the spotlight is finished.

>> a sign that we’re spending most of our “listening” time actually prepping what we are going to say (As Chuck Pahlaniuk once wrote, “The only reason why we ask other people how their weekend was is so we can tell them about our own weekend.”)

The article covers my beliefs with this quote, but then goes on to say this study proves otherwise. I guess I'm a pessimist.

Edit: As a side anecdote, I am 30 and have a much easier time hanging out with and speaking with 45+ year olds. Conversation flows naturally and my timing cues are much more in line, as opposed to the rush-to-be-first situation I run into with people my own age.
Based on SoundCloud's Android app I would say this is unlikely. The information density has dropped to JUST fitting in 2 songs per screen on my phone!

This makes it almost unusable for discovery on mobile, since I have to scroll... and scroll... and scroll... while trying to glance at track names in between flashy pictures. And the runtime in the stream disappeared quite a while ago for no reason I can think of.

Ripping off Facebook really doesn't work for a music app. Spotify at least has something pretty usable (though that too has gotten worse).
There was no version control on the transition? :)
> as the returns have diminished dramatically.

I think every person who lives because of those diminishing returns is grateful for any progress made.
Taking the article seriously, what if this grey pill revelation is just a big red pill that discourages other red pills in disguise?
> And what about the cost of the clinical trial, which could be $500m?

That's an interesting one, because that cost is entirely caused by the government. The government could for example fund clinical trials, since they're the ones who are interested in it's results (as is by extension the public).

As for the rest, if the science were freely available without a patent from the scientists, companies could still spend money making it a therapy and making a profit by doing it better and more efficiently than their competitors, and they could still get a patent on their work.

We're talking about making the science patent free, not the product.
But this is already a problem, that hasn't been solved. Facebook e.g. follows essentially American moral standards when censoring. That really crashes with e.g. far more liberal views northern Europe. People post what are regular pictures and accepted social norms in say Scandinavia but which gets removed or accounts closed down or what not because of the far more pious American morality.

This is already part of a national debate going on whether we should allow America to define our moral codes and values.

If we throw in muslims world which are hundreds of millions of people, then this stuff is going to turn into a big mess. Since I don't live in the middle east, maybe it already is a mess.
Whilst this statement is true, the torrent predates the earliest versions of ffmpeg

How so? The torrent is 12 years old, while ffmpeg was first released 15 years ago.
Hi HN, this is a personal project I've been working on for some time. This is an amalgam of several good ideas in core.async [1] and durable-queue [2]. There's a fuller description here: http://blog.shriphani.com/2016/01/25/pegasus-a-modular-durab...

[1] https://github.com/clojure/core.async
[2] https://github.com/Factual/durable-queue
Hi! I'm currently running rails-api in production and I'm expecting to run Rails 5 in API mode. Do you know if there is anything I'd have to change in the config or in the serializers (we're using Active Model Serializers)?

Thank you very much.
SlackDad – for Dads on Slack
So in 50 years we've traveled light years in safety, but only about thirty miles in naming conventions[1].

[1]https://www.google.com/maps/dir/Bel+Air,+Los+Angeles,+CA/Mal...
People criticize startups on HN just fine. What you're not allowed to do here is post linkbait titles.