skysight-inc/HackerNews huggingface dataset:
FOrward prediction of protein function from its physical structure is still considered impossibly hard if done de novo- IE, assuming no external knowledge. In principle, one could simulate proteins and extract this kind of information, but it's not computationally accessible.

Folding the protein is only one part of it. This part, while not "solved", has seen an enormous amount of progress in the past few years, such that we can often predict the coarse-grained 3D structure of a protein, although not the fine details in most cases.

Understanding the enzymatic action of proteins typically requires simulating chemistry at the quantum (bonds breaking and forming) level around the active site.

Since biologists are more interested in getting results quickly, rather than solving the fundamentally hard problems (the former gets grant money more easily), and because structures that are similar tend to have similar functions, they tend to use structural homology- similarity to a protein of known function- to infer the function of a protein.

Although much of my prior work was designed to address the forward prediction problem, I have acknowledged that shortcuts produce more valuable data. And often times, that does involve finding a gene whose protein product behavior is cryptic, and then using structural homology, and other indirect methods, to refine the function of the protein.

As for the "computer science terms", I can mention that after working with large distributed systems for a long time, I treat debugging them a lot more like how biologists deal with cryptic proteins than trying to understand them from first principles. I often run "experiments" by injecting things into the distributed systemns, and monitoring them, much like scientists monitor proteins using fluorescence.
I don't think they paid all of them, no, but I think it's entirely possible to fund a group of organizers who could motivate a significant-sized protest.

I make no assumptions about how peaceful and democratic any country in the Middle East would be, with or without US involvement.
My proven tools:
- Facebook's logout button
- Gmail's logout button
- Phone's airplane mode button
- Must-complete-no-matter-what daily to do list
- Meetings/calls scheduled for first thing in the morning or last thing in the afternoon
- Power nap
It would be a stretch to call express a framework. It's just a collection of connect middleware and a few helpers.
I am reading this while my neato robot is disoriented trying to find its home base and is bumping into every wall on the way.

I basically have zero confidence that we'll see something like what you are describing in next 2 decades atleast.
The public airing of their dirty laundry - especially the snark from so many of the participants - would kill it in my mind. There's no good reason to have this "open and transparent" conversation devolve into "let me bitch about IBM here, but don't bitch back at me, keep to IBM-only channels". It's all very childish. The whole thing should've been on the IBM back channels until they got their shit together and could agree on some messaging, and if the maintainer didn't agree with the messaging or how long it was taking to come up with it, simply fork it into the expressjs org and leave. Shouting out "I'm leaving! I'm going! I really mean it this time!" just seems like ... a child running away from "mean ol' parents" rather than an open source leader whose project work speaks volumes. It's tragic to watch this train wreck that could've been avoided by both sides refusing to posture. Like my father used to say, "shit or get off the pot, don't keep debating out loud if you're really going to do it."

Compare it to Linus' openly-hostile dictatorship, which is universally both reviled and excused by contributors, just for a moment: At least when it comes to Linux kernel, shit gets done; nobody has to question the commitment of the project's stewards; and Linus hasn't (that I recall) threatened to take his toys elsewhere.
These Gorgeous Water Maps Are Helping Identify Fake Scotch and Murder Victims
I find it really ironic that he feels the need to make contentless jabs at current political candidates in an effort to show how those candidates "spread ignorance".
> I'm curious, how fast can one load data into Postgres?

Hard to answer considering the number of variables impacting. pg_bulkload[0] quotes 18MB/s for parallel loading on DBT-2 (221s to load 4GB), and 12MB/s for the built-in COPY (with post-indexing, that is first import all the data then enable and build the indexes)

> Is it possible to import data directly from CSV files?

Yes, the COPY command[1] can probably be configured to support whatever your *SV format is. There's also pg_bulkload (which should be faster but works offline).

[0] http://ossc-db.github.io/pg_bulkload/index.html

[1] http://www.postgresql.org/docs/current/interactive/sql-copy....
The way it's described in the article, it sounds more like ASMR [1] than anything else. There's an active ASMR community in the West but it's largely not centered around eating food. It doesn't seem out of the question that the Korean ASMR community have developed a following around food.

[1] https://en.wikipedia.org/wiki/Autonomous_sensory_meridian_re...
There is Kiva systems. Their non-Amazon customers are sad but I think it would be fair to call the company a big success. I think that the warehouse logistics market is going to go big over the next 5 years. But of course I'm in a startup targeting that space so I better think that.
Yeah, it'll be because the Bolt's fast chargers are in inconvenient locations and are hard to count on since they're installed in single units.

The way the infrastructure is growing for other EVs sucks. If you had a Tesla equivalent car today that couldn't use Tesla superchargers, it would be terrible for long distance travel. It would be slow, painful, and run a substantial risk of stranding when it turns out the one charger you were really counting on has been broken for weeks and the dealer is too busy selling house-sized SUVs to care about repairing it.

This could change quickly if the big car makers cared to. So far there's no indication that they do, though.
Localization of Content at Coursera
Interesting, and I never noticed because A) I don't have a Netflix subscription and have intentionally avoided installing Silverlight (and Flash, except within Chrome) and B) the PCs I deal with on a daily basis don't have any business need for it so Silverlight's never been installed on them either for the most part.
Car aesthetics conversations being a thing of the past is another reason I look forward to our autonomous vehicle future. This isn't the futuristic racecar I drew when I was 10, but compared to the i3, Leaf, Prius, etc. I'd describe the design as "safe". But, right, these conversations are required to consist of %90 bluster.
Even further beyond one-hot: feature hashing
Stripe is solid but others I have questions about.
These are slow AC chargers which are not very useful for long distance travel.
As one would generally expect, the backing store of most hashsets is little more than a hashmap with zero-sized/no values.

In fact, that's exactly how Rust's standard library hashset is implemented since rust supports zero-sized types "in userland" (and unit `()` is a ZST):

pub struct HashSet<T, S = RandomState> {
map: HashMap<T, (), S>
}

http://doc.rust-lang.org/src/std/collections/hash/set.rs.htm...
Interesting read, but not very much information underneath the fluff -- the definition of "demagogue" combined with a cursory knowledge of common logical fallacies covers pretty much everything here. It's also interesting that an article like this is being published by an organization like the BBC; punditry is (I think) one of the most common examples of the phenomenon of obfuscation through constructed debate.
Does someone know how much it will cost?
Founders have options?
Kiva really seems to be the anomaly - and afterward, Raffaello D'Andrea went off to be a professor (though he has some new companies in the works to do with drones).
Really regulation is critical for the success of self-driving cars. Nobody is going to want to buy self-driving cars if there are ones that get into lots of crashes so I think we're going to get into the same situation we have with the FAA where the big players all want the regulator to have real teeth.

Consumer robotics doesn't have much of an entry barrier but as other have pointed out the components you need mean that prices are going to be in the $X0,000 range. That's too much for consumers but I think we're going to be seeing robots in warehouses soon.
I believe the idea in the new model is that each unit does need to pay the bills.
The DoD abhors intelligence in robots. They need a machine that's just smart enough to do a specific job -- and no smarter. They're willing to pay for the smarts -- and may accept compromise for a solution that gets them most of the way there. That makes filling their orders easy compared to the consumer market, which wants mechanical butlers for cheap.
Complaining about regulations holding you back is a great way to hide that your technology isn't actually there yet. It's marketing.
de gustibus non est disputandum

I can understand why you feel it is a hideous vehicle, it's certainly not traditionally styled. I think there's a lot more to the design of a car than the curb appeal, for lack of a better term, and with that in mind it is a very interesting car.
Thank you for the correction about std::string no longer being copy-on-write. I'm glad they changed this in C++11. string_ref also sounds like a step in the right direction, assuming it is well-implemented.
Using that argument you could almost never call something a framework of it uses a lot of libraries under the hood to make what it's doing easier. I see nothing wrong with the usage.
> Everyone knows the party can’t last forever, at some point the music will stop and not everyone will get a chair, but nobody knows how it will end – Anand Sanwal, CB Insights

I think we know in many cases. Business fundamentals haven't changed. In the case of food delivery, what's better about the year 2000 versus now? An app? Does the app make these companies more money? It doesn't look like it.
Is your concern that there are an unnecessarily large number of references to political candidates, or that there are references at all? While I am tired of the constant jockeying for position and tribalism of politics, I also wonder what would have been said of the most horrific leaders of the past during their rise to power. Without totally diverting this discussion or fulfilling Godwin's Law, there is a genuine fear among some US citizens that certain candidates could be horrific in this manner.
Narcissiana: On Collecting
The whole point was the fact that it was possible to do that is a red flag. Could you "quote-mine" physics or maths papers and get them published, as long as you claimed to believe in your results? If the journals are relying on the honor system and "good faith" to not let crap through, then what exactly is the point of them?
But, getting perhaps a bit philosophical, if you don't experience a loss, did you really "lose" something?
Write a tool for myself to group my 300+ GitHub stars
Electric cars are the future and anything from the future has to look futuristic and not like anything modern.

/s
That's because "the cloud" is centralized
Or sort -u` instead of `sort | uniq`.
Michael Moore calls Flint a crime scene, demands arrest of Gov. Snyder
DevTools Remote – Debug your browser tabs remotely via Chrome DevTools
It read like a very politically driven article to me too.
So I saw in the medium post how this compares to pbzip2 with standard pthreads. how does it compare to an alternative (say threading building blocks). I also saw in one of the papers that with a Spark comparison, would like a compiled to compiled comparison though.
Maybe they didn't underestimate the consumer as much as the Federal Reserve's desire and ability to inflate stock market valuations and other asset prices.[1] Certainly helped Silicon Valley and the unicorns, but we will see how it plays out over the next couple years.

http://globaleconomicanalysis.blogspot.com/2016/01/former-da...
You have to be there to do it, which interrupts whatever you were doing at an annoyingly pecise time.
It is a false dichotomy for Stallman to keep saying the only alternative to the word Free is Open Source. I have written to him and suggested terms such as Liberating Software, which is more accurate. Or at least Freeing Software. But he never even responded.
You are comparing apples and oranges. strcat is a library function which is easy to avoid, whereas the implicit type conversion behavior is part of the core C++ language and very difficult to escape. Non-prototyped function calls are there, but they trigger warnings on any compiler from the last 3 decades. Anyway, thanks for playing the "deny, obfuscate, shift blame for broken C++ design decisions" game.
I'm referring to Linux instances. Also Azure charges you for both ingress and egress traffic. I've looked into it many times.
This is a pretty cool new finding, and I'm pretty sure that it represents a new mechanism for neuromodulation, which is a Big Deal. I bet that this research still needs to be reproduced by third parties.
Linux doesn't seem to be a fair analogy.

If Linux had been, somehow, acquired by a large company (or, at least, access/edit rights to all of the code repositories and web presence and such), and Linus had been removed from administrative roles on those repositories and sites (or asked to remove himself and others), then the comparison would be fair.

Admittedly, one answer would be to loudly fork the project. That's happened on a number of occasions. Joomla forked from whatever it was called before a similar story (Mambo, maybe?). Node.js itself forked into io.js over similar disagreements (and then people worked those disagreements out).

I suspect some of the back and forth happening is people trying to figure out if a fork is necessary and if they actually want to be the people leading the fork (sounds like Doug Wilson does not want to be a leader, but wants to keep contributing). Contributing heavily to a project is not the same as being a leader of a project, and it is entirely fair to not want to lead a project, even if you care strongly about it, and have worked hard on it for a long time.
What do any of those things have to do with my thesis? Can you restate the main point of my argument?
I think updating the TLDR version to "No, that confuses a stock with a flow, which is a common error in economics" would help people who are going to glaze over past the first paragraph to understand the crux of the issue better.
Yep. Add to that all kind of attempts to erode the ownership of digital goods by all kind of stores which pretend they sell you something, while really they only rent it (for no good reason). DRM and its kin come along with that. Support DRM-free stores and boycott DRMed ones to vote with your wallet.
Yes, maybe if it wasn't marketed so much from economies of scale we won't be using up so many resources on this planet and making so much garbage.
Because if you "copy" a string and the copy really is just a reference to some shared data structure, changing the shared data structure later in another thread without memory barriers or other synchronization causes undefined behavior. Remember that the shared data structure will need a reference count to be updated whenever a reference gets deleted.
I live out of the dryer :-(
Possible I guess, but there is not a shred of Evidence. Milena never claimed anything of the sort either. And Einstein did his most important work, general relativity, after their marriage had soured and they were not on speaking terms anymore.
The company to watch is NRG, which has good fast charging coverage in many metro areas.

http://insideevs.com/nrg-evgo-were-1-with-37-of-the-dc-fast-...
First Krita 3.0 pre-alpha
Does the very nature of "cold storage" mean they are not monitoring for dramatic drops over SIX months?

I mean they took their damn time emptying that thing out.

It's like robbing a physical bank one wheelbarrow load of cash at a time every day and no-one notices?
RMSE and MSE are monotonic transformations of each other, so minimizing one is equivalent to minimizing the other. You can think of linear regression as minimizing RMSE if you like; it's just cleaner to do the math without the extra square root.
Seriously? You can't think of one person on the Democratic side who is "suggesting easy solutions to followers that are either unworkable or unconstitutional"?
I long ago made a decision that saves me enormous amounts of headache: if you say or do something I will interpret that in the simplest and most straightforward way possible without trying to second-guess ulterior motives or secondary (or further) layers.

Exceptions: poetry, music, jokes and other cultural expressions.

Before then I was always chasing my own tail with 'what do they mean?', which is pointless, if they meant something they could say that particular thing outright and get it over with.

This is symmetrical, so, I don't want to 'wash my hands', I would like to use the toilet. When I'm hungry I say so and when I say 'no problem' it really means that so we can move on.

All in all this made life a lot easier, though from time to time it can make for comedy.
Might make a good "Show HN"?
In C++ with small string optimization or in other languages?
Getting Started with Parse
SpaceX Jason-3 Launch Webcast [video]
In addition to phones. It's obvious hardware should be tackled as most mobile hardware has firmware that is proprietary. Plus some hardware has features that is hard or impossible to turn off.

Outside of phones there is router hardware.
Did you actually read my post? What is my thesis? What was the argument I was presenting?
Bush is a smart fellow, but he went to Harvard and Yale because his last name is Bush, not because he is an intellectual. He didn't engage in any academic activities while he was there, he engaged inn upper ass social clubs. He has a high emotional intelligence and athletic intelligence.
We have source code licenses that govern what we can do with the source code of an open source project. I wonder if it's time to start creating more explicit licenses for repositories or projects that govern behavior and the day to day activities of a project - ownership / releases / etc.

Linux would be under the 'Linus Project Governor' model or the LPG... ;)
Same I have had a few hairs that look like porcupine white / mouse brown / white / mouse brown again in stripes...

This isn't that uncommon there are quite a few things that can affect the color of the hair as it grows not necessarily just old age.
Look up "Congressman" and then tell me if you want a representative democracy.
Andrew Ng's popular Machine Learning course goes over most of the topics in the slides: https://www.coursera.org/learn/machine-learning

Linear and logistic regression, gradient descent, clustering, support vector machines, bias and variance (one of the slides was taken from the course), neural networks, etc...
Microsoft R Open
And by buying the lines of bullshit that make you feel this way you are causing the very problem, and it hurts not only you but also your peers.
Also discussed at: https://news.ycombinator.com/item?id=10903084
You're not trapped, you're as free as can be from where I'm looking at you. When I was your age I quit my very secure job at a bank to go on all kinds of weird adventures, working free-lance, going hungry for weeks, suddenly flush with cash from a payment, got my driving license, started to go on ever longer and ever more unplanned trips. In short, I embraced risk in all kinds of ways and found that - to my surprise - the people that tried to hold me back from doing this were wrong. Tomorrow always took care of itself somehow, as long as you have skills you'll have a place somewhere and some food in your stomach and every time you move to a new viewpoint you become slightly richer (but maybe not in a material sense, but that's fine until that need arrives).

Finally, when I was 27 and my first child arrived that phase ended, then it very much mattered if there was money on the table and life suddenly changed from being relatively free to being quite structured with a very high penalty on any inability to provide. I made a pretty conscious decision to stop following just what interested me but to chase the buck and with the knowledge gained in the preceding years that was quite easy.

Go see the world while the current phase lasts, sooner or later life will really trap you (compared to your situation atm) and then you're on the hook for many years before you will have some of this freedom back again. By then your body will be one that you can't compare to today (and I'm saying that as a reasonably fit person of 50+), your time will be spoken for at some regular interval and so on.

The right time to strike out into the world is now, don't worry overly about how you'll finance any or all of this, a few hundred in savings would be enough to broaden your horizon tremendously and that alone will give you an advantage over those that are rooted to their hometown.

This, by the way is what fuels my 'journeyman' projects that I try to do each year now, they're a link back to my past, basically not a new thing but a continuation. It's been incredibly rewarding to meet all these new people and to help them to achieve their dreams and contribute a little bit to solving their problems even if not a single cent ever changed hands. I very much look forward to doing another round of these this coming summer.
"OK Google, set a reminder 1 year from now to...."

Nice write up. But a bit over kill for something that you can solve with a calendar item. ...Doesn't actually have to be on google though ;)
But their business model was proven and others have followed suit with arguably more impressive technology (http://clearpathrobotics.com/)
Meanwhile in certain parts of the USA, SUV and F150 sales are starting to spike because of $1.80 gas since 15mpg "doesn't matter"

EV sales are going to be difficult in some parts of the country until gas is back at $3+
Coroutines and Fibers. Why and When
Except Microsoft don't make processors, or have the clout to tell Intel what to do, so how the heck would they swing that? Might as well speculate on "if Microsoft made Linux illegal".

They've already made installing Linux as inconvenient as they can arrange without attracting another anti-trust suit, through the use of "Secure Boot".
In what ways do you find SyncThing lacking when compared to BTSync? I started using it for work (cautiously) a couple of moths ago and have found it to be very similar (with respect to stability and ease of use) with BTSync, if not superior. Note though that I haven't used BTSync since its first days.
No reason it can't check any hostname, but all my custom SSL certs are on CloudFront.
the only installation instructions are for Windows, and there's no mention of any other platform except Android

You could also edit your comment to remove these two completely false statements... The Linux instructions are very easy to find any I don't even know how you managed to miss them!
Netwell supports SSL expiration checks as well:

https://github.com/pennersr/netwell
The state of documentation of Express 4 is not great. You have to look at the source code to see how it really works most times, or read someone's blog about how it used to work in Express 3 - but no longer does.

Whose decision was it to go from a "batteries included" web server module to one where users had to assemble a bunch of ad-hoc third party components to make a usable web server? I'm looking at you, body-parser.
Clothes can sit in the washer for hours. :-) I transfer when I'm walking by to go to the bathroom. Actually, with my AppleWatch, I usually unload dishwasher, washer/dryer when I'm told to stand up and move for a minute.