skysight-inc/HackerNews huggingface dataset:
Mutations in the BRAF gene, to name one druggable example, are a cause of many different types of cancer - melanoma, some breast, small-cell lung cancer, etc. Under the current paradigm, each type of cancer is treated as a different disease and requires a different clinical trial. This is bad.

What should happen (and is beginning to happen, with "basket trials") is that cancers are grouped by their genetic profile, instead of their tissue of origin. The BRAF V600E mutation is targetable with Vemurafenib, and so that drug should be used regardless of whether you have breast cancer or lung cancer.
I'm sorry that you think academia isn't "with the program". There's lots of great basic and translational research going on in the academic sphere. Can you at least elaborate, if you're going to paint us all with a broad brush?
Light pillars project the town map onto sky after snowfall in Finland
In my experience dedup in ZFS performs horribly on hard drives.
That was obviously sarcasm.
Ask HN: Is it illegal to tell someone that you quit a company?
Background: Obvious burner handle. I worked at a company. I resigned. I told someone that I had quit, almost three months after quitting, and after starting a new job. I have a confidentiality agreement, which is valid for twelve months beyond my resignation date.

I'm now threatened with legal action because I informed someone that I wasn't working there. Setting aside whether I can win against the confidentiality agreement, the argument I'm seeking is that I'm obligated to make it public knowledge, and thereby making the knowledge that I have quit inherently non-confidential.

I did own shares, so there may have been an SEC reg about that.

IRS requirements?

In all honesty, I think it would have been potentially making me complicit in fraud (if the company raised money while claiming that I was an employee) had I not informed anyone, so I did have reason to share this knowledge.
I found the FreeNAS community to be a bit difficult to work in - less than 32GB of ECC RAM? Using something other than RAIDZ2 with 6+ high performance drives? You're terrible, and you'll lose all your data!
You've described Fossil.

http://fossil-scm.org/index.html/doc/trunk/www/index.wiki
He doesn't work for GitHub, but I agree with your assessment of the tone and wording of this post.
So, I'm fairly new to this... how would you do automated installation of client certs on:

* OS X machines

* Android devices

* A Nest Thermostat

> For bonus points you can extend 802.11x goodness to your wired desktop ports as well.

Though, that only works if you have either a Smart or a Managed switch that understands that it needs to tag frames from that port with RADIUS-dictated VLAN tags, right?
I think the point is that it lives on a spectrum. If inflation was so bad that your savings would be worthless tomorrow, you would run out and buy as many materials goods and services as possible. If you knew that tomorrow it would reach 10 times its current value, you might go hungry for a day to cash in on that.

In either case, you're obfuscating the consumer's real demand due to 2nd order speculation. Using some particular good as a unit of account fundamentally introduces a distortion into the way that people elect to spend / save. And many people have different takeaways from this fact. If you're a goldbug or a Bitcoin enthusiast, you think that inflationary pressure is evil and deflationary pressure is good. If you're really into Keynesianism, you might think that consumption is good and saving is counterproductive. If you're the Federal Reserve, you think there is a right amount of spending that expert economists should target by tinkering with the money supply.

For anyone interested, I personally think the real answer is to look for ways to design a system that removes the distortion entirely by introducing a currency that cannot be held. In other words, a financial system in which the unit of account, the grease in the gears of the economy, only exists in the brief context of a transaction. The actual holding of wealth would all be done using electronic "shares" of real material goods, sort of like what you're buying at a commodities exchange. In this world, people's personal savings would be electronic, hyper-diversified stock portfolios. The "currency" of this system, if you could even call it that, simply acts as a yardstick for understanding relative costs, rather than needing to understand the N^2 different exchange rates of a typical barter system. You would hold micro shares in thousands of different products thanks to automatic software tools that blended expedience with your desire to personally elect what goods you wanted a long position on. In this way, the appreciation / depreciation of your personal savings would rely quite transparently on current values of the goods it represented. Crucially, removing this layer of abstraction would make it much harder for your fortune to evaporate purely on perception of value (see: Zimbabwe) since you would never give it away for less than what the underlying goods were worth to you personally.
just use Gmail, I never get any unwanted email to go outside of my spam folder, you should not be running your own mail server, that is dumb.
So use a real issue tracker. Most of the big ones integrate with github. Why should they reinvent this wheel?
> From Agile Development...

I assume the irony is intentional?
Go get does not start with a git clone. If you go get example.org/pkg/foo go fetches https://example.org/pkg/foo?go-get=1. So coordination between go and github could implement something for deprecated repositories without changing anything in git.

More details here: https://golang.org/cmd/go/#hdr-Remote_import_paths
Slightly offtopic but they use commissary food for currency in prisons as smoking was banned years ago. http://www.wsj.com/articles/SB122290720439096481

Mackerel was chosen since it's cost was closest to $1USD, and nobody wants to eat it. It also has unique markings so they can track down theft from each other.
This would be the NHTSA probably.
AMD's 64-bit ARM server chip Seattle finally flies
Apple did not need to move fast because Flux has been there on desktop for ages. They need not copy but implement the basic idea of flux.
It sounds like something is wrong with how your hardware or OS is doing power management if you don't see a difference between idle and full load. Also, what else is in your system? 50 ways seems pretty high. For just the CPU, the most power-hungry Atom I can find has a TDP of 10 watts.

http://ark.intel.com/m/products/59683/Intel-Atom-Processor-D...
I work with a guy who worked on the Digital products side of the Amazon store and he said it was all done in Perl + Mason which sort of sounds like a nightmare, though he says he enjoyed it.
Pfft. Outside of a few specialist areas, most people's data isn't backed up, and if it is, it's on SD cards, thumbdrives, iCloud or the occasional portable USB hard disk tossed in a backpack.

The most difficult thing about setting up a home NAS was swallowing the cost and reading about all the tradeoffs I'd inadvertently made.
Is this a legit business now? The only thing that comes to mind when I think of zoosk is annoying flashing ads and spam from several years ago.
Code of Merit 1.0 released. A meritocratic approach to project management
Threads was much better, and far more depressing, than The Day After.
> Testing DDR Read/Write.

> Testing DDR Read/Write: Memory map.

> Testing DDR Read/Write: Data lines.

> Testing DDR Read/Write: Address lines.

> Testing DDR Read/Write: Own-address algorithm.

> Testing DDR Read/Write: Walking-ones algorithm.

> Testing DDR Deep Power Down.

> Testing DDR Deep Power Down: Entering deep power down.

> Testing DDR Deep Power Down: In deep power down.

> Testing DDR Deep Power Down: Exiting deep power down.

> Testing DDR Deep Power Down: Read/write pass.

> Testing DDR Self Refresh.

> Testing DDR Self Refresh: Write pass.

> Testing DDR Self Refresh: Read pass.

> Testing DDR Self Refresh: Entering self refresh.

> Testing DDR Self Refresh: In self refresh.

> Testing DDR Self Refresh: Exiting self refresh.

Yes Galaxy s4 modem, please provide unlimited access to all government agencies of all my phones content and communications.

> Samsung Root CA cert1%0#

Fantastic, you also inject your own root certificate. Thanks.
> There is at least one thread where there's already been confusion around it.

It's impossible to prevent everyone from getting confused. What's more, it appears that purple_haze's confusion didn't materially alter what they had to say.

> At first, I thought this would be from someone who worked at GitHub, because I didn't understand why else it got upvoted.

I guess it got upvoted because people liked what it said and/or thought it contributed to the ongoing discussion here on HN. We're generally not too terribly authoritarian and/or credentialist around here.
Jesus, this sounds so complicated. Mental models of self-behavior are effective ways to change those behaviors, but it sounds like these guys are piling way too much on at once. My most effective behavior change models have always been simple and almost singular. The one I'm exploring now is "Dopamine in your brain correlates with motivation." Others have been "Plan ahead all at once so you aren't tempted to procrastinate", "Measure it and visualize it to drive yourself forward", etc. I've effectively changed my behavior in massive ways by playing with simple models of myself. Constantly thinking of all those cognitive biases and mental errors seems like it would exhaust me to the point of paralysis.
What makes you think they didn't? I saw lots of people look up, check the people around them and keep going.
I don't agree with much that Tom Coburn says, but he's right that 'data silos' are a big problem in cancer research. To elaborate on a few points:

- While enrolling 500 people with breast cancer in a study might be easy enough at one academic hospital, there are lots of rare cancer types. It's fiendishly hard to gather enough cases to do real research on these, and samples are like gold, so people are resistant to sharing.

- There's lots of duplication of effort. While studies funded by the NIH are required to deposit their data, what's being deposited is raw sequence data, which requires lots of computation, disk, and skill to turn back into useful information about the mutations in cancer.

- The clinical data (phenotype) that is released with studies is often incomplete or vague enough to be useless

- Getting data into and out of these access-controlled repositories is, to put it mildly, a pain in the ass.

We do need to protect people's privacy, but removing some of these hurdles would go a long way towards accelerating the field.
The "thing" is... my code sits in git at the end of the day. That is portability like no other. Can I migrate issues? Sure![1] What[2] language do you prefer to work with?

The real "thing" is, my git repos do not care where they are hosted. All I need to change is my origin.

[1] https://github.com/sorich87/github-to-bitbucket-issues-migra...

[2] https://github.com/jeffwidman/bitbucket-issue-migration
It has happened before with emergency fixes....
*Bitcoin, no capital 'c'
Ian Murdock in His Own Words: What Made Debian Such a Community Project
The Linux kernel can do some really strange things when a drive fails. I had an external drive fail to the point where if I wrote to it, commands like ls would fail and be unkillable until I rebooted the system. I wonder if that's similar to what you were experiencing, masked by the shiny UI
True. But presumably they could pass this proxy fee on to the content creators.
NFSv4 did NOT predate either the VAX filesystem or AFS.

I can tell you that as of 2000, Linux didn't even have a functional NFS lockd. FreeBSD's worked, but didn't handle partial file locking.

NFSv4 was a pile of fail for a VERY long time. Maybe it's better now, but given that everybody still seems to use Samba (or sneakernet) for file sharing, I'm wouldn't bet on it.
There is nothing specific in Pi Scan that requires the two supported cameras. It may work on any recent camera that can run CHDK. The difference is that if you try it and it doesn't work, I can't do much to help find the problem if it is not an A2500 or ELPH 160 because those are the models I have in hand.
The way to save bits is to copy them onto new media every few years. That's what the Internet Archive does -- we're currently phasing out 2 terabyte disks for 8's.
I'm regretting building my NAS. It's expensive, the storage is small (16TB of drives gave me ~7.9TB of usable space) and any question or doubt about your configuration prompts responses like: http://blog.ociru.net/2013/04/05/zfs-ssd-usage#comment-17223...
> It's really convenient, ...

> ... would have expected something on Synology's status
> programs to show a problem, but they were all green,
> so that was annoying.

So perhaps not all that convenient.

I went down the QNap path a couple of years ago, on the assumption it'd be robust, well patched, more convenient, and basic functionality would work / be tested. I was wrong on most counts, and am now basically scared off these low-end SOHO systems entirely.
Dear archagon, please stop spamming
This is a bit disingenuous but not completely. I think a comparable service would be outdoor wilderness survival training, like BOSS in Boulder. Part of what makes it effective is that you are dislodged from an environment in which you can comfortably cling to the heuristics you already use to get by. In the new environment, you have to adjust all your norms and it provides more of a blank slate, cognitively, on which to imprint the lessons.

The CFAR stuff is like this too, but rather than being an outdoor wilderness survival school, it's just a survival school. It's even weirder than what it would take to survive in the wilderness, because the space of mental tools is so much more vast than the space of physical tools tailored to one type of environment.

I would guess that many CFAR employees would like their service to feel more like a "boot camp" sort of thing -- a transformative experience in which the intensity of learning and the bandwidth demanded are extremely high compared with what that intensity and bandwidth will be back in regular life. But I also think they don't want it to feel like an indoctrination, and would want to preserve and even enhance someone's ability to be skeptical, even about CFAR itself.

In that sense, promoting self skepticism, CFAR is very different than a cult, and just because it shares some superficial aspects of a cult doesn't mean it's fair to make that comparison.

But, but, I still do agree with you that CFAR has work to do to prove that they are not just a marketing engine fleecing bored rich people who fancy themselves seeming like philosopher savants or some shit. Merely having verifiably good, open content, like the LessWrong sequences, is not enough. They further have to show that they are willing to change, and verify that they aren't just a certain kind of boutique fraternity.

I for one would really welcome hearing ideas about alternative ways to teach rationality. For example, I recently read the science fiction book The Black Cloud by Fred Hoyle, and I was particularly interested in a part of the book where humans communicate with a far more intelligent being. Hoyle's writing is fun and all, but what I really thought was cool was the idea of a human (Hoyle himself) trying to emulate a being far smarter than him, and how believably he did this. But of course, on closer inspection, we should expect that Hoyle's portrayal would not be good enough, or else such superior intellect would be in our grasp merely by imagining how it should sound.

I think I got more out of reading that fiction book, in terms of thinking about how to think better, than I did out of vast swaths of LessWrong. Maybe that says more about me than anything else, but it is a data point that maybe there are all kinds of ways to elucidate the useful tools of rationalism, and the format of CFAR might not even be close to optimal unless your goal is to vend a status merit badge to a certain set of semi-wealthy people.
Are you not a fan of commercial works of art?

Also, I think you are conflating entertainment with art. They are not the same in my opinion.
For us Netflix refuses to play the high quality because the beamer is not to the liking of their copyright protection.
"The only interesting thing it does (apart from storing constants like its serial number and variables like your phone book and text messages) is to generate authentication responses"

The most interesting thing your SIM card does is run arbitrary programs that can be uploaded to them, without your knowledge, by the carrier:

https://www.defcon.org/images/defcon-21/dc-21-presentations/...

The SIM card is a full computer, with its own CPU and memory, that lives inside your phone and that you have no control over.
> Go get does not start with a git clone.

Fair enough. (I don't use go, so I'm unaware of pretty much all of its internals.) [0]

> ...coordination between go and github could implement something for deprecated repositories without changing anything in git.

A couple of things:

* This only fixes things for Golang. It doesn't fix it for the couple-thousand other tools that pull things from Github.

* I never suggested changing things in git. That would be freaking nuts. :) EDIT: Or did you mean "without changing anything in the git repo"? If you meant that, then I strike this bullet point and apologise for the noise. :)

* Frankly, having a well-known file in your Git repo that contains meaningful tags seems far more compatible than changing git, or altering the $BUILD_TOOL<->GitHub integration... for one thing, the convention could be trivially adopted by non-git users. :)

[0] Thanks for the documentation link, BTW! :D
The aforementioned quote should be: "If you value your data, you should use ECC RAM. Especially so, if you use a checksumming filesystem such as btrfs or zfs."

There is no use investing money in offsite backups if the onsite backup is corrupted already from faulty RAM.
There's a TPM-like mode with hardware isolation built into ARM for years, used for disk encryption keys, DRM, auth keys, fingerprints, etc on IOS and Android. See: https://en.wikipedia.org/wiki/Trusted_execution_environment
This is no knock on you, since you aren't there to develop the Issues platform anymore. But I don't know how much private repo developers are hurt by the points made about Issues because they probably don't use it.

I mean, Issues is not really a full-featured issue tracker. It could have been, and maybe would have become one when you were still there, but right now, it's not. And if you do need something more, and you have some resources within the organization, you're not going to stew over Issues...you're just going to use something else. Jira...Pivotal...whatever.

I'm sure GitHub doesn't feel that Issues is where they make their money. And/or that developing Issues further either won't make them anymore money, or not enough to matter. People don't choose to use GitHub for its issue tracker, and even if they had a great one, people still probably wouldn't choose to use GitHub because of it. And so Issues languishes in its current state.

But Julian Dunn has a point to make--maybe this press burns enough for GitHub make changes after all.
This. Github's enterprise base is at least partially a subset of their open source population. If Github doesn't keep OSS momentum for their product, they lose the perceived "default client" status to git repositories. OSS and eventually enterprise starts looking elsewhere.

This is getting more and more relvent since solid competition is starting to crop up everywhere. Gitlab, Bitbucket, GOGs, Gitolite, Gerrit. Not apples to apples of course, but Enterprise has a lot of decisions when it comes to git control.

Even the things that could be considered Github "lockins" aren't really so: Google's git-appraise[0] could make pull-requests portable, Github's wikis are portable by their very nature[1], software like git-issues[2] could make issues portable. Not in the immediate, but decentralize-everything is a rising sentiment.

The only real lockins I see are Github's work-flow and social community. If either become toxic, developers will start to look elsewhere. Like Microsoft, I'm sure Github can ride the majority-player wave for years before it starts really hurting them, but simply saying a community-centric company only has to look out for their paying community's interests is short-sighted.

[0] https://github.com/google/git-appraise
[1] https://github.com/gollum/gollum
[2] https://github.com/duplys/git-issues
It should be the min req on any server, really.
Absolutely! I'm also the father of our second child, 100% sure ;-)
Is your dual core atom the first generation atom, that shipped with a 945 chipset? IIRC, the cpu was about 10w, but the chipset was 25w :(
I don't know about bitcoin, but your logic is flawed: "The Titanic is working right now. I'm floating in the middle of the ocean, drinking wine, listening to great live music" and we know how that went.
Agreed. Something isn't right here. An Atom system should be drawing much less power at idle.

I have an older low end AMD system I built with the intention of having it be low power. It draws around 40W at idle.
Is translation “Uberizable”?
I missed that. Still, banned for things other, cooler posters are allowed, but I can beg to be forgiven. Good to know.
Indeed, if you have a second cell modem or smartphone, the modem can connect to the cellular network and provide an IP over Wifi, and the smartphone can use wifi to connect to it. Thus the smartphone is protected by its OS's firewall and any compromises stay on the cell modem, the same way they do with home internet connections.
In fact I was expecting a few of my friends asking the question to know if she was actually in Europe with me when she got pregnant. Gotcha!
We are discussing the OP which is a 36 TB storage system, which warrants things such as ECC RAM + ZFS. A home NAS, for the typical end user, will not reach 36 TB. Storage a small percentage of that on AWS or Torsnap will, over time, cost more than the ECC RAM.
Baidu's Silicon Valley AI Lab Releases Warp-CTC, Open Source AI Software
Could you explain how that's hypocritical? I don't see it.

I actually think it seems like pretty good evidence. They're adding a (according to the author) questionable feature with notable possible downsides while ignoring a long standing problem with the simple solution because it (allegedly) furthers their goals to have the problem continue to exist.
Just get an FSF laptop for security. You can even trust the hard drive if you use software encryption of all your data. I'm not sure what remains insecure on that class of hardware?
I want it on workstations and laptops, too. I've seen bit flips in the office.
There's no such thing as a libertarian currency. Money was invented to provision government. Everything else is a commodity. Currencies can only be issued by a sovereign with the ability to impose taxes to drive the value of the currency
This seems like someone saying "I don't agree with the direction that BitCoin is heading in" and then taking his ball and going home. A bit dramatic yes, but not uncommon in open source projects. It's like someone saying "Linux is dead because it doesn't confirm to XYZ principle", which seems to occur every other Tuesday. Forks happen.

It seems like he makes some cogent criticisms, for which the best solution seems to be to fork the project, or begin developing for any of the other *coins that were so popular a couple of years ago. But BitCoin has the dominant brand and the people who control the mining and the source code can do whatever they want. Something tells me that bitcoin itself isn't dead because there's been too much invested in it by too many people, whatever the problems. But it's dead in the eyes of the author and maybe for several others, and that's all that matters in the context of his blog.