skysight-inc/HackerNews huggingface dataset:
If you go digging around you'll find dozens of other similar results in the past five to ten years for dozens of various compounds, some of which produce larger effect sizes than this one. This is nothing to get excited over.

It is interesting the way in which various groups leap upon some research reports but not others. The challenge is always having the context for the broader state of research to understand whether it is meaningful or new or not.

The present mainstream view of Alzheimer's is that amyloid (and tau) clearance is the way to go. Immunotherapies are the most developed tool, but that is so far proving to be hard - it is too early to say whether failures in clinical trials are because it is hard or because amyloid clearance isn't as useful as thought in this condition. Which could be for any number of reasons including that amyloid-related biochemistry is the problem, but clearing a particular variant or stage of its aggregation doesn't touch that problem area.

Amyloid levels in the brain are in fact highly dynamic on a very short timescale. That Alzheimer's develops slowly supports the view that the condition is a slow degeneration of natural clearance mechanisms, such as the filtration performed by the choroid plexus, or the more recently investigated peristaltic passage of fluid out of the brain by other channels. E.g.:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245362/

On that latter point, the Methuselah Foundation just a few days ago seed funded a startup company that will investigate whether reversing the degeneration of peristaltic fluid passage with aging will improve clearance and thus stop the progression of Alzheimer's. It's based on as yet unpublished work by Doug Ethell at GCBS Western who presented at Rejuvenation Biotechnology 2015 ( http://www.sens.org/files/conferences/rb2015/RB2015-Program.... ), and has the merit that it should be a fast failure if the theory is wrong, unlike many of the other efforts in Alzheimer's research.
Wrong. 2000mg/Kg = 2g/Kg, two grams of the chemical per kilogram (1000g) of the subject. To give you an idea, that's 160g of chemical for an 80Kg human. Quite a lot, but nowhere near impossible to consume...
Mice are ~30% similar genetically to humans, so a surprising amount of transfers. Rats are a bit more similar IIRC, but mice breed quicker so it's easier to do bigger studies...

Source: Used to work in mouse research on addiction (alcohol, cocaine, nicotine, etc).

Edit: This link gives even more specifics on the similarity: https://www.genome.gov/10001345 -- 30% is probably accurate, but in terms of function, it's even higher.
My understanding is that Facebook is increasingly moving towards a functional representation of state akin to event sourcing and gleaning performance via the "micro services" approach and one way data flows the paradigm facilitates.
If you reduce everything to how much money you could have otherwise pulled out of the stock market you are going to have a miserable life.
Turing CEO Martin Shkreli arrested in securities fraud probe
I somehow doubt that fracking is a CIA plot, or that the Saudis voluntarily gave up hundreds of billions in revenue as a favor to the USA. The Saudis have no intention of cutting production because they know that if oil prices rise, Fracking will ramp back up again, they'll lose commensurate market share and be back where they started. Their best path right now to capturing as much revenue as possible is to exploit their low cost of production by out-producing everybody else.
No. Understanding what's different about Martian geology and Earth geology, for example, can help us refine models of solar system construction, which in turn can refine how you model the Big Bang and the elapsed time of the universe.
>>and having an MBA from a top-5 school gives a person a huge advantage.

Certainly. There's a saying that having an MBA from Harvard will guarantee you at least an interview anywhere in the world.

The problem is that the vast majority of MBAs did not get their degree from Harvard, or even the other top 4 schools. They got their MBAs from regional universities or no-name business departments.
Bugbot: open source GitHub Issues client for Slack
The U.S. Economy Is Doing Only Half Its Job
Presumably these "people" you speak of are actually different people (unless you have evidence of the parent choosing not to use statins?)

People tend to vary wildly in choices and opinions. Who knew!?
If it were that low, we would not use them as models.

Also bear in mind that mouse models are merely part of a large set of animal models that we use: https://en.wikipedia.org/wiki/List_of_model_organisms#Verteb...
The real question is what does it matter to you? Nothing a person says is correct just because they have the right title or label.
Exactly. What happened was geologists knew about shale oil and gas deposits in North America for years, and then finally someone figured out how to extract it economically given prices in the mid-late 00s, probably because they wanted to make money. They made money, hundreds of firms copied them, and the Saudis responded to the threat of market share loss by pumping lots of oil. There was no centralized decision making in this process, just a bunch of individuals, firms, and governments reading the tea leaves of the oil market independently.
there _is_ a huge amount of smart folks who worked or works on build systems.
Sadly, it seems everyone is 80% better than the others in something and 20% lacking in something else.

For example, the SCons wiki has some interesting comparisons.

https://bitbucket.org/scons/scons/wiki/SconsVsOtherBuildTool...
Actually it's just something between 0.8g and 8g, 160g is a safe limit, not the therapeutic dose.
She's completely fine with anything else than red meat.
Missing an important part here: Telegram and co. is a cloud storage service where as WhatsApp, Signal, Threema are not. Think about this... your messages are stored and not delivered and deleted on the server. Telegram has the encryption and decryption keys but claims there are in different countries/jurisdication. So is this safer than deliver+delete? I think NO.

I wished somebody would analyze if WhatsApp protocol is using encryption also on iOS, groups and images as this website claims: https://github.com/WHAnonymous/Chat-API/wiki/WhatsApp-incomi...
Well, we do have an example of a governmental agency that is free from political control, i.e. the federal reserve. We could have something like that for research, can't we? After the appointment of a governor, the organization could function on its own without politics. Other examples include supreme court of the United States, BBC in the UK etc.
I'm a huge fan of Dorco razors. In addition to their normal prices on their website being about 60% less than razors from Gillette and Schick. You can also usually find a 20-30% coupon code to make them even cheaper.
Doesn't CMake count as a successor?
Maybe they are not the same people?
I would be interested to hear from you, and anybody else with similar experience, what were some of the most valuable courses you took. That is, for someone with no interest in pursuing an MBA but with the opportunity to take a course or two, what are the must-haves?
Author here, comments welcome :-)
> I wish more elderly people would decouple their loss of youth from their self regard.

I think Garner's point is that we live in a society in which other people's regard for your worth is a function of your age.
Much better than ReactOS
This Year in Connected TV: The Biggest Trends of 2015
There are also distributed file systems (MooseFS, Gluster, Ceph) which can duplicate data across physical locations, protect it with checksums, scrub in a distributed manner and auto-heal, all of that transparently.
Nice catch - fixed. Too early for arithmetic.
Well, it's not for a sore knee. Is there anything more unapproved than an irreversible disease that destroys your mind in the space of a few years? It's not like cancer, from which you might be cured, or at least with which you can have a meaningful life until your eventual death. It is a slow motion process of erasure that is well on its way at the moment of the first diagnosis. Taking the wrong medicine could shorten your brain's life of how much, a year perhaps? Still worth trying.
> Before WhatsApp criminals communicated using different means which were easier to monitor

Perhaps sloppy criminals did so, but the careful were engaging in schemes more like what we see on "The Wire". Meeting in secluded, noisy locations wherein privacy was all but guaranteed.

People, including not-convicted criminals, have the right to privacy. If the NSA and law enforcement are going to make it harder and harder to find private places through dragnet collection, it should not be surprising that the populace will seek to reclaim privacy.

If it's an arms race, as you say, it's an arms race that law enforcement was winning at so one-sidedly that the relationship was becoming abusive. Tools like WhatsApp, Telegram, Signal, etc., are the citizenry's first efforts at serious competition.
Why I captured this MRI of a mother and child? Because I can. /article
They don't have a presence there. There are no WhatsApp employees in Brazil.

I have a website that is accessible in Syria. Do I have a presence in Syria? In Antartica? In Trinidad? In Russia?
2015: Octopart’s Year in Review
Of course there are many alternatives (of the alternatives, I can only really recommend cmake).

The problems broadly speaking are:

* Assumptions: autotools assumes that only a basic Bourne shell is available, and a basic make, and that make is a good way to build projects. All of those are questionable, and certainly if you get rid of the assumption that you're only allowed to use ancient tools, you could immediately make autotools better, if only by removing all the shell cruft. But then someone will complain because your project doesn't compile on SunOS 4 or whatever.

* Familiarity: When I'm packaging your project for Fedora, I will not be pleased if you've used some obscure or half-assed build system. If you're using autotools, I may dislike it, but at least I can fix things.

The second one is a difficult one, because until your build system gets popular, it will never be familiar, and us packagers will keep cursing you. Once it's popular, it'll probably be quite crufty because it has had to handle all the horrible corner cases that autotools can do now.
Can you upload to B2 by mailing a hard drive? I can't see that stated anywhere on the web site, nor does that service appear on the pricing page.
It's about pedigree. An MBA from an unknown school will not open the doors, however great the education was.
That Knuth quote appears on pg. 4 of my 1969 copy of TAOCP Vol. 2. That's 46 years ago. And yet we still make these fundamental mistakes.

Fortunately, when I went to college, my first CS prof loved TAOCP, and those were probably the first three CS texts I ever owned.
That just doesn't sound reasonable. University students, to me should be a full-time focus, also very often have one or multiple part-time jobs or even a full-time job while attending classes and doing their school work. Surely being a judge doesn't take 100% of someone's time, and this is also a topic likely close to the commenter. Also, did you look at the date of his tourism website post anyhow?
Many people are quite cynical about Big Pharma
I think this is what happens when you believe your own bullshit too hard and for too long. It's one thing to go around acting like you're God's gift to humanity, but if you start actually believing it, large unpleasant men with guns will come and explain how you've got it wrong.
I had similar thoughts after reading the associated article: is there a series of MOOCs one can take to learn what Hotz learned (or at least a fraction of it)?
>The US has never been shy applying its laws abroad

Which I think is insane as well. My criticism is not limited to Brazil.

Companies should beholden to the laws of the places they reside. Not everywhere that has internet access.
Finally! I really hated it when 5.4 broke all my code with global references, was forced to stick to 4.1. The most useful feature

Finally I can upgrade, go PHP 7 ....

;)
Goodbye, Dubai: Yahoo to Shutter Final Office in Mideast
Congress adds contested cybersecurity measures(CISA) to must-pass spending bill
Curated things to do for travel experiences
On the front page - https://news.ycombinator.com/item?id=10750928
Apparently, Whatsapp is only end-to-end encrypted on Android, where it uses TextSecure. On iOS, it still uses RC4.
That's going to be heavily weighted based on your personal background and the quality of the specific class.
Add yourself to KSI video with this new app
Sounds to me like you are putting a political-correctness test or lens on what should be a mathematical and science based issue.

Shame on you for bringing subjective issues into an objective issue.
There's a growing body of evidence that Alzheimer's is really just "Type 3 Diabetes":

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769828/
What are the substantial barriers to deploying something like CONIKS? It doesn't seem to help the multi-device problem, but in general it does seem useful.
I wonder why you're being downvoted. Reflexive instinct for someone who admits they have sociopathic tendencies?
Thanks for your reply.

> That's going to be heavily weighted based on your personal background

Could you elaborate?
I think more like "differently bad". However of all the build systems out there (and as a Fedora packager, I have had to deal with many), I'd prefer if you used either autotools or cmake, because those are the ones we're most familiar with and we can fix things.
State of Microservices
No one is suggesting an internet without laws. Just that you be beholden to the laws where your company resides. Office in the US? US laws. Office in Brazil? Brazilian laws. No office in Turkey? No Turkish laws.

Blocking imports or sites is fine, if your countries laws allow you to do it. But calling them lawbreakers? Not so much.

We already have precedent with the US going crazy over persecuting people who reside outside of it, and that's something the US needs to stop doing, not something more countries need to start.
I'm not an expert, but human lifespans have only risen to relevant heights very recently. It's simply not enough time for it for evolution to kick in.
The system is biased toward drug monopolies. He merely exploited it.
Does everyone at IBM still use a 1024*768 monitor? Come on, guys, we've moved on from 12px sized fonts.

Edit: BTW, irony intentional.
If you start your post with "I'm an authority" then you are inducing the appeal to authority implicitly through Priming.
Definitely a heavy user of recreational drugs. This crime may have been related to that.
Talk is cheap. He is more than welcome to compete in ILSVRC or on Kaggle or any other competitions of his choosing. Maybe release some code on Github or even an API. There are a lot of options out there to really show how your technique is better, not just talk about it.

"How humans do it" isn't necessarily the only way to solve a problem. We don't know how we add 2 numbers in our minds; but the computer can add 2 numbers orders of magnitude faster than us.
Ask HN: Is there a service that runs Bitcoin nodes for me?
What I understood from the PopSci that passes HN every now and then is that the 'Alzheimer protein' is just some normal protein that the brain makes during normal operation every day. In your sleep the brain contracts and 'flushes it out' somehow, but over the years the protein accrues and you suffer dementia. Obviously that's super oversimplified and probably wrong, my source being skimmed over PopSci and all.

Since dementia is a disease that happens at a late age, there doesn't need to be a reason why it is there. It happens a long time after reproduction, so its effect on evolution is minimal, worse it could even be evolved as a mechanism to curb older specimens in the species.
Idono. Sociopathy seems to be pretty common among the executive class.
If you have a laser like focus on maximizing profit (and supposedly most businesses do), you've already fired everybody you can and cut all the hours you're able to already.

But no, they don't just sit there and take it. They pile money into think tanks and advertising campaigns in order to try to sway public opinion (see above).

One of my favorite tactics is when they pretend that robots that do minimum wage jobs all cost $minimum wage + $1 and raising wages is simply going to make them all go out and buy those magical robots.
Most people would take "be at risk of health problem" against "not lose your mind". The question (and the effect in both sides) are still worth asking
IMO it doesn't matter if there are better alternatives, as that's mostly a concern for new projects. The thing is, there's a good chance that you'll have to use autoconf at least once in your dev life, sooner or later, because very large number of major opensource projects use it (with no clear intent to switch). So at least you've got to be prepared and know how autotools are working.
How Techies Armed the Predator, Nearly Stopped 9/11, and Invented Remote War
Non-paywalled version:
https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&c...
I wondered how the "static" visualizations were produced, then noticed the link under the image: http://bl.ocks.org/mmalone/bf59aa2e44c44dde78ac

There you can see the code and watch it run. Neat!
any suggested reading material on the topic?

The Art of Computer Programming, Vol. 2, (c) 1969, by Donald Knuth, has quite an extensive discussion of random numbers, their properties, algorithms, and tests. It's about 160 pages in my edition. It's very readable, and even if you skip all the exercises you will still get a very good grounding.

I don't know how much has changed in his more recent editions. And I don't know how if there are better books. But, in general, you can't go wrong by starting with Knuth. He's one of the all time greats!
Poll HN: Who is your favorite registrar?
Curious to see which registrars are the favorites and why.

EDIT: The list is somewhat arbitrary. They are the ones that I seem to encounter the most often, so please excuse any bias in the choices.
AWS (Route53)
Google Domains
Godaddy
iwantmyname.com
Name.com
Namecheap
Other (please comment!)
If I was slowly losing my mind, I'd even try experimental drugs that came with a 20% chance of sudden death.

There's not much worse than having your mind die while your body is still alive.
Signal having all three qualities author is blogging about: security, multi-device cync, and usability basically makes this post and SMU theory nil. This looks like a case of "I have my theory, now lets bend facts to fit the theory".
Realising the iPad Pro’s Potential
If the goal is to simply make a compelling argument then stating your title immediately induces bias.
I think that will, unfortunately for me, change pretty soon. I sell/repair old watches, and horological tools.

I am seeing the price of used watchmakers tools, and mechanical watches(Omega Seamaster, Tudor(a cheaper Rolex), and pretty much every high end watch go up in price. Hell, even Elgin's, and Bunrus watches are going up faster than I want.

I used to be able to go to EBay, and CL and scoop these watches, and tools up. Not anymore. I thought the smart watch would put an end to mechanical watches; so far it's been the absolute opposite, but might change if they ever get a smart watch so right--the people with money need to wear it?

As to furniture--I think it's just time? Why buy IKEA, when you can buy an antique that you can give to your kids? The IKEA will go to the Craigslist free curb route?

I take that back. Some of you would give a friend/relative an IKEA piece? My father once gave me his old underware. He meant well--I think? Oh, and his old Sears tube socks. They were so worn, the elastic strands were beyond broken--the polymers couldn't keep their positive/negative charge. I thought I could use them to polish my truck, but they just didn't even work for that. My dad meant well--just very frugal. Or, a fool? I haven't quite figured it all out?
Couldn't have happened to a nicer chap.
This is a useful walk through optimization in python.

> The lesson is clear: do not write Python code as you would do in C. Use numpy array operations rather than iterate on arrays. For me it meant a mental shift.

I think the lesson is that "performance critical software requires attention to very many specific details." Using a garbage collected language that allocates objects on the heap by default means that you'll have to take special steps to change the default behavior of the system. You will see very similar behavior with C++, Java, etc.

> I didn't use Pypy so far because it only supports part of Numpy, and not Pandas, Scipy, and Sklearn. It may be that Pypy supports enough of Numpy to run my closest distance code though. If that's the case, then I'll blog about it soon.

I'll confess, I was eagerly waiting the pypy results. IMO using pypy means I get the best of both worlds: more code that can be naively python with python idioms and still yield sufficient performance. For critical algorithms where I can't hit sufficient performance, it's appropriate to use cffi or something to optimize.
MarkelSoft Super iOS Apps
If you use this on someone else with Alzheimer's and they die or are injured, you will almost definitely go to jail. You could likely use it on yourself, but look at it as an extreme, it is still less bad than suicide I suppose... But you don't know what the side effects could be.

It kind of scares me that people think they can buy untested chemicals online and self-medicate with them. But then again I'm not into the whole "Bath Salts" scene which is all about that.
4,265.99 CZK ~ 157.82 EUR (Czech Republic)
I gain interest in the first case :)
provides no proven benefit in humans

I know there's very good reason to be wary of mouse models, but in cases (as this appears to be) where the physiological mechanism of disease is both (a) understood and (b) the same from mouse to human, a little less skepticism may be warranted.
I had to change the title a bit to fit it within the character limit, which led to some personal editorializing of Wired's title, but I wouldn't classify any Pentagon project as rogue, even if they were able to skip a number of bureaucratic hurdles, and I also wouldn't say that remote war was an accident.
I came to say the same thing.

midcentury anything has been going strong for at least the past decade or more. It's not just furniture, but art, reel-to-reel recorders, record players, nearly anything that came from the 50's is gaining traction in nearly every niche you can think of.

The prices are starting to level out a little bit as well, making it more affordable. There's also a TON of retro shops where I live (Minneapolis) where you can get amazing MCM furniture. Places like http://findfurnish.com/ where you can get a very nice Danish Teak credenza for around $500.

And yes, I know, midcentury can be anything from the 30's on up through the 60's. It is a rather a broad category of time.
Ginkgo Biloba [1] is very solid at helping preventing Alzheimer's, even in some cases slowing it down when it's already occurring. Lots of research on the benefits of Ginkgo. Yet most don't know about it.

[1] https://duckduckgo.com/?q=ginkgo+biloba+alzheimer+site%3A.ed...
Ugh. For a person with $1,000,000 in assets, the difference between +/- $100 in marginal utility is almost zero.

Yet all the psychological studies will show that said person HATES losing $100 much more than they like gaining $100. It's a major effect.

Heck, if you even give people the same amount of money but FRAME it as a loss versus a gain, people change their behavior. The marginal utility is identical!

Loss aversion is MUCH larger than any difference in marginal utility. It's a real thing, that has huge effects on our politics, our economics, our media and our entire lives.

TL;DR: Article writer has absolutely no idea what he is talking about.