skysight-inc/HackerNews huggingface dataset:
Most of the pitfalls that the author identifies can be avoided by simply subscribing to the TDD workflow. A little peace of mind actually makes programming pretty fun.
namesilo.com

+ filthy :) and shameless plug -> http://sitemeer.com/ns (gets $1 off of new registrations .... and yes, it is an affiliate link - for affiliate-free please see the URL above please)
You have a good point. Keep in mind that this is a mouse model of Alzheimer's disease. That is, these mice have a genetic defect that causes similar changes to that seen in human Alzheimer's disease. These mice do not have the same disease as in humans.
No, I am not ;)

More seriously, are you unhappy with the default layout of developerWorks blogs? What change do you suggest? Not that I am in any way responsible for it, but I can certainly pipe your suggestions to the power that be.
Fair enough. There's also medicinal value in LSD and marihuana, so I'm not going to challenge you on that.
Sure, but our original discussion, lost in the sands of time, was about UI libs and how "regular windows users" have lots of QT apps. In the enterprise all bets are off, and all kind of crap is used, including tons of Swing, Flex, old VB6 apps, etc.

In fact, as I've just checked it again to be sure, the whole initial point was a non starter, trying to paint Windows as equally fragmented, UI-wise, as Linux.
> More seriously though, I've always assumed that the antiques market is driven by nostalgia and longing for the past. The younger generation today seems to have very low levels of nostalgia and longing for the past.

As a 31-year-old Millennial, I can tell you that nostalgia and longing for the past is very much alive and well among my peers.

It's just that all our nostalgia is concentrated on the '80s and '90s (probably more the first half of the '90s than anything else, but there's still some '80s and late '90s nostalgia mixed in there), and antique furniture is probably the very last thing you think of when you think of those decades.
Also, any other company spending money to spin up production and get FDA approval would face its incumbent competitor suddenly dropping its price to cost. This lasts until the new entrant goes bankrupt or stops selling, and then the price jumps right back up to gouging territory.

The only way to eat the incumbent's lunch in a worthwhile way would be to start out larger, so you can absorb the startup costs, and find a way to produce at lower marginal cost.

The FDA approval process for generics is part of the problem there. It should be enough to do a chemical analysis showing that the molecules are the same. The current FDA requirements are akin to having to prove that your new vodka can get someone drunk just as well as vodka from other vodka makers. The active ingredient is ethanol. Ethanol made by you and ethanol made by AB InBev is chemically indistinguishable. As long as you can accurately report concentration, for the purposes of dosing, you shouldn't have to prove that ethanol still gets people drunk when you are the one making it. You should only need to prove that the amount of ethanol in your vodka matches the amount printed on the label.

So if your doctor prescribes 9.3 g ethanol, taken orally, once daily, your "compounding pharmacist" can give you a 1 oz. shot of any 80-proof beverage. It doesn't matter if it's name-brand top shelf or generic rail, so long as it's 40% alcohol by volume.
I would disagree that there's no "exposure" component for many of those other cancers.

* Eating red meat

* Eating processed meat

* Drinking 3+ glasses of milk daily

* Inadequate levels of vitamin D

These are all well-known to the nutrition community to increase cancer risk.
From tfa it does not sounds like he is interested in competing in ILSVRC. His point is that fitting a 500M-dimensional model to hundreds of millions of training examples != intelligence. That is, deep learning is incredibly good at pattern recognition but it is not going to get us to AI as most people understand it.
Where did I say CIA plot? That is a strawman you have erected. The Russian economy was helped substantially over the past decade by rising oil prices, this economic improvement formed the cornerstone of the current Russian administration. When oil prices were slashed, the Rubble fell by half. Suddenly now there are problems at home, and Russian military expansion has been curtailed. Nation states are perfectly capable of grasping the economic importance of certain key resouces for the modern economies and know where to turn the screws to encourage behavior without jumping straight to war all the time. The Saudis did not voluntarily give up billions of revenue, they calculated that the opportunity cost of pissing off America, which has significantly helped keep the royal family in power for decades, would be too high. Not every decision is a straight up comparision of projected revenue numbers, sometimes large and powerful entities take into account expected value as well.
but autotools looks like someone completely gave up on
producing a good, decent or even bad solution and just
tried whatever didn't completely and utterly fail at the
task.

That is more or less what happened, by their own admission, "why does it look like gorilla spit?"

https://www.gnu.org/software/autoconf/manual/autoconf-2.65/a...

Although I disagree that they didn't produce a tolerably decent solution. It's a near hopeless task to account for the differences of dozens of operating systems, even if most of them are all Unix-like, yet autotools still tried and mostly succeeded. Nowadays some build tools don't even attempt to solve this problem and only target Windows, Mac OS X, and Ubuntu, and usually only the latest version of each.
Pretty sure some Feds were looking to pin him after his story broke earlier this year. Protip: Be a quiet or unknown capitalist oppressor
This was pretty much free-market business

No, it wasn't free-market at all. Much of Shkreli's strategy relied on the barrier to entry created by FDA regulations. He priced the drug just low enough that it wouldn't be worthwhile for another manufacturer to get approved.

Nothing free market here. It's rent seeking, pure and simple.
Developer levels: the right skill set for the job
Yes but none of those are mutually exclusive which is the point I'm trying to make.
I like the phrase 'utility hysteresis'.

I would say that, at least academically, the difference between 'diminishing marginal utility' and 'loss aversion' is appreciated. To quote course material, 'When directly compared against each other, losses loom larger than gains'.

The difference in perception on the gain and loss side has been tested some, and the curve is supposed to look like this: https://goo.gl/PS8Z7c
>>> Ikea and the ilk produce throw-away furniture.

I have to agree with you there. Most of the stuff I've bought at IKEA I've had to reinforce using Gorilla glue and heavier screws so it won't fall apart within 6 months.

It helps, but I stopped buying their stuff after I graduated from college.
The Inside Story of How a Food Startup Cracked
See my reply here for a possible approach: https://news.ycombinator.com/item?id=10577132
Open Parse: middleware to bring up a Parse.com-like API in your own Node.js apps
The negativity in this thread is really a shame. I would expect better from HN.

> This particular MR image, though, was not made for diagnostic purposes, nor even really for science. No one, to my knowledge, had ever made an MR image of a mother and child. We made this one because we wanted to see it.

> To some people, this image was a disturbing reminder of the fragility of human beings. Others were drawn to the way that the two figures, with their clothes and hair and faces invisible, became universal, and could be any human mother and child, at any time or place in history. Still others were simply captivated by how the baby’s brain is different from his mother’s; it’s smaller, smoother and darker—literally, because there’s less white matter.
This is heartening news; if not a cure, at least it suggests a promising avenue for future research into this terrible condition.

This LiveScience[1] article is an easily read summary that also mentions a critique of the approach.

Given the unfortunate history[2][3] of falsified Korean scientific research, it would be prudent to withhold judgment until these results have been reproduced in other labs around the world.

1. http://www.livescience.com/53019-epps-chemical-washes-away-a...

2. http://www.nytimes.com/2009/10/27/world/asia/27clone.html?_r...

3. https://www.washingtonpost.com/news/to-your-health/wp/2015/0...
Thank you, you made Pypy move higher on my todo list.

You have a good point about gc and memory layout. That's why I like C or C++ when writing high performance software. You can control memory locality more easily than with other languages.
Similarly if you start your post with "I am not an authority, but..."
Hippies often did the same thing. It's pretty dumb to just throw compounds in your body without having a guestimate about their effects.

In the future, medical clinicians won't have to guess as much because adult stem cells can now be created from red blood cells, allowing personalized medication with a petri model of actual patient tissue, to screen problems like interactions and allergies before administration.
I'm not treating them like children, you missed the point of my last comparison. I'm saying that this article holds a definition of conservatism that is highly stereotypical and not at all representative of much of academic conservatism. I'm trying to defend my conservative friends here.
"Hey someone committing a crime is writing notes to each other! Quick, order all pen manufacturers to send us copies of everything people are writing!"

"Sir the pen manufactures said they can't comply"

"Ok that's it, stop the sales of all pens"

Then everyone starts using pencils.
> Storage media are of course block devices, that work or fail on 512-byte sector boundaries

It's been my experience that the entire disk typically stops working at once. "Bad sectors" are a 90's problem.
Assuming no gravity, friction, or interest and your money is a perfect sphere ;)
Yeah, it's not like they are disposable machines that get thrown away after one scan.
Yeah, I know it's a damned hard problem, but that's why I posted it the way I did. This was mostly an attempt to head off the typical cargo-cult hate against autotools.
AOMEI Partition Assistant 6.0 Crack and Serial Keys Download
I think if you avoid the very bottom of the range then Ikea products are pretty good. We have a solid wood Ikea dinging table that is wearing a lot better than the expensive one we had previously.
I suppose trade deals would require too much coordination between those inept national administrators. I guess it is also too bad that there are no international standards like TCP/IP becuase that would require coordination as well. And its a good thing there is no coordination, that way we dont't have any international spying programs on citizens.

/s
And yet, hypocritically, she negatively judges the youth as such.
as life saving drugs practically advertise themselves anyway

Ummm.... no, they don't. I have a friend who works in the industry and you'd be surprised how cautious some physicians are. The decision to treat a patient with a new drug isn't "oh! it's better, let's use it!", it's much more complicated than that. Even great drugs need to be promoted.

Also, you can't compare the costs of marketing and R&D. You don't spend marketing dollars unless you think the return is greater than 1 (you make back more than you spent). If drug companies stopped marketing their drugs, they'd end up in a worse financial situation rather than a better one. That extra revenue means more R&D spend!
Ask HN: What search engine do you use?
A few years ago, I made a concerted effort to move off of Google products. At the moment, the last remaining products are Google Search and Android. I've tried most of the alternatives, and used both Bing and Duck Duck Go, however remained unsatisfied by the quality of their results. Have they improved much in the past few years? Is there a good search engine I am missing? Should I just stay with Google?
You Commit Three Felonies a Day (2009)
https://nccih.nih.gov/research/results/gems
When you are this talented at communication in general it must be triply annoying to be condescended to.
Bechdel test
Hell, most research magnets spend a fair bit of time idle, it's often possible to get that time for "free" for a variety of reasons like no show test subjects.
>hyperbolic orbicurve

>global realified Frobenioid picture

You just made that up.

--Maths Professors
> if you're moving house you can just throw out the old stuff.

At my college (UT Dallas), we had on-campus apartments. Not dorms, but an actual apartment complex on campus.

The best place for new residents to acquire furniture was by the dumpsters. It turns out that most people moving out would just chuck half their furniture and leave it by the dumpster. Every year from May to August, there would be copious amounts of furniture at the dumpsters. If you were a new resident, you were quickly told that the best way to acquire a couch was to head over to the nearest dumpster and take what you see.

I attended UTD from 2003 to 2007; I don't know if things have changed since.
Why Python 3 Exists
edit: sbierwagen points out below that my comment is wrong, the source was pointed out, I just missed it.

> A worth to read article by [Mike Malone](https://medium.com/@betable/tifu-by-using-math-random-f1c308...) explains the problem with Math.random() in more detail.

Probably the source of the shuffle (though it was not mentioned, its visualisation was used) considering the old implementation had been there for about 6 years (and had been partially busted until a few weeks ago)
An issue with this contrived example, as well, is that Rx has an error flow at the stream level, so typically you are more likely to build things similar to:

userActions(combined)
\
\--u1-----------------e1--X
\--u2---------------------------e2--X
\--u3--...
\--u4--...
\--u5--...
\...
e1
\
X

While you could do your analytics message on the combined diagonal stream, you'd probably want to do it on the horizontal streams.
Mouse models are rapidly becoming obsolete as it's becoming easier than ever to model entire, differentiated tissues grown from red blood cell-derived adult stem cells.

It's also now possible to do clinically-useful testing of targeted treatments using genetically-edited control tissue cultures against unedited tissue cultures.

The point is that it's better to test something that is as close to the patient as possible, not guess with other species or even other people whom express genes differently.

FYI: making a new mouse models requires lots of chopping off heads of mice whom don't possess the desired gene. While transgenic, highly-edited living models might be nice, there's probably a more humane/simpler/reproducible way to do the exact same thing.
Average life expectancy is a commonly misunderstood (and widely misrepresented) concept. We hear things like "Humans really only lived into their 40s in the Stone Age," or what have you. This is untrue.

Average (arithmetic mean) life expectancy was a lot lower because it was heavily skewed by infant mortality. Up until very recently, many more babies died within their first few years of life. We've dramatically improved our ability to produce and distribute food and medicine, which has had a profound effect on infant survivability. But we haven't actually lengthened the average life expectancy of an adult who survives the first few years of childhood by all that much.

Point is, plenty of people have been living into their 70s, 80s, and 90s for as long as we've existed as a species. That said, the prevalance of diseases like Alzheimer's might be a fairly modern aberration, perhaps owing to lifestyle, environmental, and dietary factors.
Well I mean yeah, that is an argument that floats around lately (one that I support). Namely, that the idea of every startup getting acquihired encourages low-quality startups with no purpose except getting eventually bought out. People need to be attached to their venture personally for it to get their full dedication, and if you just plan on selling it in the future anyway, that won't happen.
On a retina screen, 12px is practically unreadable, particularly in Helvetica Neue, which is quite a light font. To be honest, IBM's site has had tiny fonts for as long as I can remember, they just become more problematic as resolutions increase over time.
The Dutch National Geographic article contains more detail and reads reasonably with computer translation:

http://www.nationalgeographic.nl/artikel/genocidaire-slachti...

Regardless, the scale of slaughter is staggering.
Company CodeBots
yeah, you're probably right !
Cross-compilation is another. When I was building packages for the Fedora MinGW (Windows cross compiler[1]) project, it was mostly trivial to get things working if the package used autotools or cmake, and an impossible nightmare for everything else.

[1] https://fedoraproject.org/wiki/Features/Windows_cross_compil...
>"Please keep in mind, if you find areas of improvement in V8 and Chrome, even ones that—like this one—do not directly affect spec compliance, stability, or security, please file an issue on our bug tracker."

Worst idea ever, this not-a-real-bug got a correction in just a few days without even being in the bug tracker, while there are real bugs stalled for years in the tracker. Writing a blog post and making a lot of noise on the internet works way better than using the bug tracker.
A very short history of data science (2012)
Yes however one side has science and evidence and the other side has lobbyists and oil companies. There's a wealth of independent research proving climate change.

The question is not whether or not CO2 has an insulating effect, this is intuitively obvious with even a basic understanding of chemistry and physics. The question is whether we're emitting enough of it to cause environmental problems diverse from those naturally occurring. Additionally, the effects would not be as obvious in something like a terrarium because the greenhouse effect works with glass as well. That's why it's called the greenhouse effect.
I'm going to have to disagree that you shouldn't only need to show chemical equivalence. You need to show biological equivalence.

A few years back the FDA approved a generic version of Wellbutrin. They didn't ask for bioequivalence testing and as a result, the formulation dumped all the drug into the body, drug levels spiked and patients got sick. The FDA eventually made the company reformulate the drug so that it was truly interchangeable with the branded drug.
I agree. Veering slightly off on a tangent but another major (and oft-forgotten and undervalued, I think) advantage of the degree path is that a good course will lead you down the best and possibly most efficient paths of discovery for the important things, and also give you a bit of a kick in directions you maybe wouldn't naturally go on your own, but which turn out to be very valuable after some uphill struggling.

These are things you can figure out, and discipline yourself into, but on your own time and with a fair probability you won't do a great job, when self-learning. With a degree much of that work is outsourced to specialists who have a lot more context and ability to iterate on experience, and that gives you a much smoother path to just focusing on your main job - learning.

So, a good compromise, and the reason I ask this question, is to get recommendations on what to learn, then decide myself how I will do it and on what schedule, etc.
The “verb second constraint” could explain how people acquire language
Web Components article feedback
Hey guys, i wrote an article about Web Components introducing the elements that are under this big umbrella. Can you please give me some feedback about it? Written english and content wise.

Some people tell me it's too long, others it should have more images to illustrate the shadow DOM...

http://blog.premium-minds.com/old-legos-made-new/
Yep. There's a reason why people in technology complain about the "Damaso Effect". Even though those Harvard MBAs get mocked by "real programmers", they get the last laugh because they decide what most of those programmers work on.

All of that said, the networking opportunities drop off rapidly, even from Harvard to Stanford or Stanford to Wharton, much less out of the top 5. The education is the same, and the academic quality of the students is probably better at non-top schools, but you're not meeting people who are so loaded and connected that they'll hand out sinecures and venture funding (which are two forms of the same thing, but that's another discussion) to their drinking buddies.
I'm kind of the opposite of you. I like to change out my furniture every few years. I'm not going to pay for something that will last forever because I don't want to use it forever and the resale value often isn't terrific.

In the past I have bought Ikea stuff and I was pretty happy with it (the Poang chairs were a favorite of mine for a while). It worked well for me and was easy to sell on Craigslist when I was done with it.
> Ummm.... no, they don't. I have a friend who works in the industry and you'd be surprised how cautious some physicians are. The decision to treat a patient with a new drug isn't "oh! it's better, let's use it!", it's much more complicated than that. Even great drugs need to be promoted.

And yet somehow the word on new drugs still gets to doctors in the rest of the world where public advertising of drugs is illegal. Any ideas on how this miracle occurs?
I'm curious which drugs the NIH has launched? Can you list them?
Star Wars “The Force Awakens” – World Premiere Transmission
I think you're actually supporting the point. The people actually doing the research don't care whether they're being financed by VCs, or by NIH. As long as they're getting the money, they're happy.

Moreover, if you're advocating pushing private investment even farther out, there are undesirable side effects. It means that the decision about what to pursue stops being driven by what there's actual demand for, and becomes a matter of political policy.

We can already see the effects of this. Government investment in medical research is not proportional to the number of sufferers, or the expected gain in QALYs (Quality-Adjusted Life Years). It's clear that the investment is strongly slanted toward research on maladies that have distinct demographics - i.e., that are represented by organized voting blocs. Thus, you'll find far more money spent, proportionately, on research for HIV than for something that's pretty widely distributed like colon cancer. I believe it's wrong for politics to drive this so strongly.
Major studies of ginkgo show minimal, if any, benefits.[1] It has not been proven that there are "very solid" benefits of this substance, thus far.

http://www.mayoclinic.org/diseases-conditions/alzheimers-dis...