skysight-inc/HackerNews huggingface dataset:
I don't think that GA4GH is literally using CORBA. The data model is not implicit, it's explicit (there is a schema). The "data silos can communicate some things ... but not personally identifiable information" is a constraint placed on the alliance by legal system. As for the semantic web, every bio project I've seen which adopted the semantic web ultimately failed -- the semantic web seems like a great idea, but attempts to fully implement to the point where it's useful for research always fail. So I think they're focusing on areas where they are likely to succeed (collection and processing of large amounts of raw and derived data using pretty conventional processes, but at a much larger scale, with a solid authentication and access mechanism).
Any site that you find interesting likely has an element or structure that causes it to skew that pattern. Wikipedia doesn't follow that ratio, for example. Also the metrics around social media stuff are so bizarre (and so easily manipulated) that it's hard to get decent data. Trump's engagement metrics on Twitter are in the fractions of a percent. CEO posts on LinkedIn get a few hundred reads and four comments. So is that 100:1? Or is 400 reads versus a million followers the important ratio? It's all over the place and you can pluck whatever curve you want by selecting datasets and ignoring important outside influences such as LinkedIn's idiotic design or Trump's pacing of Tweets.
Nomad.Network
Learn shortcuts for any app
I agree strongly with this. I started out in biomedicine many years ago with the same aims as the OP, but after a lot of experience, I think that announcing the database resource is just the first step, it's an easy one, and all the hard problems are the ones listed by x1k.

Based on what I see happening in large orgs with lots of machine learning resources is the development of new techniques to generate large amounts of homogenous phenotypic data across many measurement modalities. These large orgs have biologist/doctors: the small number of people cross-trained well enough to move between the two fields with ease. These orgs have gathered enough resources to compel the leading researchers to work with them, and they're starting to publish interesting papers.
Direct link to Vice article: http://motherboard.vice.com/read/pirate-bay-founder-peter-su...
In the phrase "technical manager", technical is an adjective; the noun is manager.

What would lead you to expect a smooth path to being hired as a tech manager without tech management experience?

It's a different job and the skills required to succeed have less overlap than many devs think.
How would I keep up with developments from Spideroak? Their blog (https://spideroak.com/about/perspectives ?) does not appear to have an RSS feed.
Wish I could do it but who has $750 to spend on an aptitude test?
Very nicely presented. Sadly, many of us had to learn gradient descent from Numeric Recipes in C.
Rails: Getting validations out of your model
AutoDesk AutoCAD 2014 Crack and Keygen Full Free Download
so you cron the process over periods of time and update all files' encryption?

at some point you need to acknowledge that there is one ultimate limitation to encryption: if you want to ever see the contents of an encrypted file then someone else will also be able to

the only way to completely 'secure' information is to destroy it, and even then you have to do so meticulously
I think your vision of these tools is far more sophisticated and capable than the current reality. It's certainly been an industry dream to produce tools that work at the high level you've described, but they have very limited domains and thus far, less than impressive results.
Even most of your average Apple fanboys don't like the new case. Yet Grover still manages to find ways to defend Apple in a very lengthy argument that can basically be summarized as: battery cases are traditionally ugly, so Apple isn't any worse than the competition.

As for power users needing battery banks/cases; I don't know what is construed as power usage, but my iPhone 6 can't last a full day away from the charger. It last as long about long as the iPhone 4 it replaced.

Yeah, in a "typical" weekday where I go from plugging my phone at home to plugging it in at work and back to plugging it in at home the phone has "good" battery life. But on the weekends where I spend all day outside, it dies before the end of the day unless I carry a battery bank.
This is true. Which is why we really, really need checksummed filesystems. I am very worried that this hasn't made its way into mainstream computing yet, especially given the growing drive sizes and massive CPU speed increases.
Japan’s 105-Hour Workweek
This sounds a lot like auto-completion in a good IDE.
While we're sharing anecdotes, I had (reading) glasses from the age of 8, but I never once wore them in school all the way through to the end of high school. My vision slowly deteriorated until I truly couldn't read normal sized text without glasses.

I genuinely don't know the science here. But I've never heard such a thing from a doctor (glasses hurt your vision), and it smells like folk wisdom BS to me.
Yes, I think those large companies may finally have a slim chance to revolutionize data integration, but it is too early to tell yet. We will see.
A lot of these anecdotes are the frustration with dealing with people that waste your time. I guess it's not limited to just the startup space but one thing I've learned is that there is an unlimited number of people that are willing to waste your time and boy is it frustrating.
I used to be a huge Rails fan, but that was a long time ago. Now, I like simple frameworks like Sinatra and Compojure (for Clojure), with some experiments using Meteor.

Way back when, I liked keeping the source code for CRuby and Rails handy and back then the code base was interesting to explore. Sadly, I really don't know how Sinatra, Compojure, and Meteor work since I have spent very little time looking at the code.
In their limited defense, they do position themselves more as an educational program than as an incubator.
Maybe so. I guess it's one of the symptoms of depression.

There is also research that indicates that school results improve, and the students report that they feel better if the school starts later in the day, in sync with what appears to be their natural clock. So maybe there is a correlation, but the causation might be just the opposite unless we are talking about clinically depressed people
(that I don't want to trivialize in any way.)

I doubt that there is anything natural at all about the standard office-hours, and I also doubt that we are a exclusively day-active species. There are many accounts of alternative sleeping patterns or segmented-sleep.
Looks like somebody rediscovered how power law distributions are prevalent in so many different statistics.
Are those images renders or actual product? It's a really nice looking watch, at a great price.
This is why end-to-end data integrity with something like T10-PI is a necessity. The kernel block-layer already generates and validates the integrity for us, if the underlying drive supports it, but all major filesystems really need to start supporting it as well.
"Blue" is just a name for a particular range of wavelengths of light. Those are "blue" by definition. The "why" is because we declared it so.

The gravitational constant is not set by definition. The reason for its value, and the reason why this value is such that the force is so weak, is not known.

It could just be arbitrary, but nobody knows. And even if it is arbitrary, it's a completely different arbitrary from how "blue" is arbitrary.
Color Management
What is with these artifacts in this image? Are these real watches? It looks like some image samples poorly photoshopped together.

http://gardannewatches.com/products/gardanne-black-brown-wat...
I wonder if X-ray images of records could be decoded as audio.

It's been done with regular pictures, there was a really good article about this that I can't find anymore. However it should be more complicated with x-ray images as they are a different mapping between the disc and the image.
Elm with a magic backend could outshine meteor. Elm apps are fast.

Edit: magic translates to instant backend and using just one language for everything.
Elm-native-ui seems like a step in the right direction:
https://github.com/elm-native-ui/elm-native-ui
The "less than half for cash" one is something I used to see from customers all the time when working in a bar. You'd say "£10.50, please" and they'd reply "£10 for cash?" as if I'd happily chip in 50p myself (till shortages need covered somehow) instead of having to accept a card payment. I never understood the mentality - it costs £x, so pay £x or go away
Is anyone doing old-fashion landlording these days? I'm trying to break into that space, but I have no idea what I'm doing and could use some advice from someone who's done it before.
My best one to date: In early 2002 we got an offer of a well-funded start-up to take over our company. We had the technology, they had the sales, the marketing and the $.

The CEO met me in an office in SV so lavish it would not have been out of place as a Ferrari showroom. Halfway during the meeting - we didn't hit it off all that well - he made the momentous announcement that if we did not accept his offer we'd be going on a head-on collision course for a game of chicken and he had just thrown away his steering wheel.

I just laughed, bade my farewells. They failed spectacularly (not a bankruptcy but the service was shut down) several months later after burning through a very large fraction of $30M.

What puzzles me to this date is what he thought he was trying to accomplish by showing me that he was a reckless cowboy with very little sense for business relations but it certainly wasn't going to end in a partnership with him 'at the wheel' (since he'd just thrown that out).

He's still around, selling toothpaste.
Strong moderation with clearly defined goals and rules could go a long way, granted you had the resources to back it up long enough for it to become self-sufficient. Stack Exchange has some categories with strong moderation and rules. The problem with SE, in my opinion, is that posting there feels literally like working without being paid. There's almost no fun in posting answers on SE, while there is still a bit of fun posting on HN.
At best, he is trying to have it both ways: Saying it outright and then raising the tone a few octaves into dog-whistle range.
They assumed that you'd simply pocket the 10 quid rather than book it officially so 'everybody would come out ahead'. Never mind that you'd be committing fraud.
> I'm not sure why physicists think gravity is a force and Pauling exclusion principle isn't.

http://physics.stackexchange.com/questions/44712/is-pauli-re...

http://physics.stackexchange.com/questions/141865/how-does-t...
Oh, is that all? There's nothing special about that. Any decently capable editor should be able to do likewise. I don't know about Vim because I don't use it, but I would assume it can, and I know very well that Emacs can because I do such things in Emacs every time I write code.

Of course it doesn't work exactly the same way; for example, running a single test doesn't involve highlighting it and telling Emacs to do something magical, but rather flagging it in a way that's specific to the test runner and then doing M-x compile RET RET to point the test runner at that file. The first time I do that, I have to tell Emacs what command I want it to run, but that's no great hardship, since it's buffer-local (each file I'm editing has its own value) and, being a simple test harness invocation, need change only when the filename does. If it matters to me, I can put this information in a configuration file, so I don't have to worry about typing it out even the first time. So far, it hasn't mattered to me. (And, yes, when I run a single test this way, I still get coverage information. Linting happens inline, as linting should, so doesn't really figure into things here.)

The mechanism differs somewhat from what you describe, but the result is the same. Just highlighting the desired test and invoking a keybinding might be a little quicker and more convenient, but so far it hasn't seemed enough so for me to go to the effort of writing Lisp code to do it. It wouldn't be much effort, but since invoking a specific unit test alone takes about a second, it also wouldn't save me much time, which is why I haven't bothered doing it.

A major point of interest here is that none of this workflow is specific to a single language or a single toolset. It works the same way across all the languages I use. Since I work in multiple languages on a daily basis, that's very important to me. It sounds like you work primarily, perhaps exclusively, in Java, so that's not as important to you. The problem is, you seem to have assumed that nobody else's tools can do the same awesome things your tools can do. As I hope you've gleaned from this comment thread, that is rather untrue, and proceeding from the assumption that it is makes you come off as both ignorant and arrogant. What you do with this information is, of course, entirely up to you.
As soon as your name is out there as a successful founder you'll get a ton of this, the more media coverage you get the worse it gets.
I'm not sure it was ever widely published, but it is named:

"Proposal for No First Use of Nuclear Weapons: Pros and Cons, Policy Memorandum no. 28
(Center of International Studies, Princeton University, September, 1963"

More details can be found Google books[0].

I wrote a review of a related book which I found in the same pile: There Will be no Time[1].

[0]: https://books.google.com/books?id=sVq6jgEACAAJ&dq=Proposal+f...

[1]: http://ethanheilman.tumblr.com/post/29405762446/there-will-b...
Cash is so that neither you nor him needs to pay tax on those $10 which makes up for the lost 50c.
Sperm donation, 1k/month and I have to go in twice a week.
Ahh I never considered that option
These are my own personal experiences, summarized for potency
Pareto ?

Robert Kiyosaki suggests 80/20 is an average but in the world of money, the most suitable rule is 90/10.

http://1-million-dollar-blog.com/what-is-9010-rule-of-money/
> Keeping Muslims out of your country is a "fascist idea"?

Of course it is. Spreading xenophobia and fearmongering against some <mexicans, muslims, put some ethnic/religious minory here> is a classic in the first steps of all so called fascist regimes. Xenophobia and fascism are inseparable concepts. One can not live without the other.

And remember that Trump had tried also this dirty trick against hispanes, but it just didn't work so well in that case. I didn't be surprised if poorest black and asian people be seen also as targets and 'enjoy' a similar treatment in the future.
US town rejects solar panels fearing they 'suck up all the energy from the sun'
A better way to use UserDefaults in React-Native
Microsoft Windows usage statistics over the years
> kept in jail until you cough them up

My understanding is this is contempt of court in the US, which comes with 6 months in jail at a time, at which point the prosecutors have to proactively request the renewal of your imprisonment, and usually don't.
> A lot of these anecdotes are the frustration with dealing with people that waste your time.

Having been both a founder and an employee, these examples don't really ring true to me. At least personally I've seen a lot more employees and consultants wasting founders time than the other way around.
Ugh. That's pretty horrible. Thanks for the link- I hadn't seen it.
No, I didn't.
I've been looking at this as well and I also have very little idea what I'm doing. I found a spreadsheet on Bigger Pockets that helps evaluate properties as rental investments by plugging in some numbers. Apart from that, I just have some alerts set up on Redfin and a general idea of what parts of my city would probably attract good tenants.

But I've seen enough stories about nightmare situations that I'd rather cover all my bases before jumping in.
Aren't there potential liability issues arround this? Where you may have to take responsibility for a child.

http://www.cnn.com/2014/01/23/justice/kansas-sperm-donation/
Somebody who dedicates his time to publicly spew this toxic attitude will likely not archive success that is pleasant for him.
I don't know about magic, but Elm with an Elixir/Phoenix backend seems quite nice. http://www.cultivatehq.com/posts/phoenix-elm-1/
The thing I'm still looking for: proof that VR has crossed from novelty to something useful. Maybe somebody here has seen it?

Take drones as an example. For years, people were buying them purely on novelty value. But now you can see actual commercial demand in agriculture and in filmmaking.

As a counterexample, take Google Glass. Tens or hundreds of thousands of units sold. But every time I asked somebody what they were using it for, I got answers like "it's so cool!" Once the novelty value wore off, they got put in drawers and never used again.

As a third, take smartwatches. When the Pebble came out, it was all novelty hype. But gradually people found uses. It's not a massive revolution, but there's enough of a market there for a small number of companies to have modest success.

So far, everything I've seen for VR mirrors the '90s wave of VR enthusiasm: lots of "erhmegerd 3D" and "think of the future", but no evidence of workaday value. People have theories of what that will be, but no proof. It could be too early, of course; sometimes technologies take time to find markets. But by now with hundreds of thousands of devices in circulation, I'd expect to see some proof from early commercial adopters. Is it out there?
Maybe he knew that he was going to get bankrupt soon and tried to bluff and scare you into accepting his acquisition offer, so he would get your technology on favorable terms and look good to his investors.
VR has far more physical constraints and problems than normal videogames/computer usage. There's likely to be a big hype-wave [1] growth curve if it's very good because of those reasons. It's going to take a long time for people to simply reconfigure their living rooms and home offices to take advantage of VR in any numbers, even longer in a corporate environment. Plus it's unclear if people will physically want to spend lots of time moving around so they can properly interact with virtual environments. Even fairly prosaic use-cases are going to suffer from gorilla arm type interactions, and just sitting at a desk with a keyboard/mouse and headset may not be enough of an improvement over today's desktops for people to bother -- and may in fact be an interactivity downgrade in many use cases.

1 - https://gridjumper.files.wordpress.com/2010/10/picture-5.png
> they already make shitloads of cash

And I don't understand why they wouldn't to make more. Removing all those pesky restrictions would just give them even more sales than they already get. All I can guess is like I said above - they value control over reach and profit (calling them control freaks was very appropriate ;)).

> Perhaps my brain is poisoned by looking at this through the eyes of Big Media. How would this work?

I'm looking at it simply from perspective of potential creator. Most of the time I personally don't care about "big media" and its dull commercial mass market art. But going back to creators - for me it seems pretty simple. Let's say someone wrote music, a book or made a film or computer game or whatever other artistic work. They need to break even and profit to be able to create more art. So, the way the do it is by reaching as many people as possible, right? And distributors come in play and help them to increase that reach. The more distributors they use, the more potential people they'll reach. Any kind of exclusives would mean lower reach for them. Pretty straightforward, no?

> If all media that is made available is made available through all channels at the same wholesale price, then retail sellers can only distinguish themselves through ease of use, lower overhead (which enables lower retail price), or other "value-adding" things like social networking integration.

Distributors can compete on features like you said. Exclusives of course give them an advantage, but only they benefit. It hurts both creators and people who are forced to use certain distributor to get what they want. For instance, many computer games (which is probably one of the most successful art forms for independent creators today) are released through as many distributors as possible, obviously to increase reach.

> What's to prevent the five or ten real media distribution heavyweights that would inevitably emerge from doing the very same thing that Big Media currently does to everyone: using strong-arm tactics and back-room collusion to keep Big Media weak and in a position where the distributors set the price?

Good question. In theory competition + anti-trust laws should prevent that. Collusion and price fixing are really illegal. But if competition is strong, they won't be interested in doing it anyway. In practice I agree that anti-trust laws are rarely enforced, and bad players manipulate the market way too often.
It provides both. mbox was a known evil 20 years ago, so it's a bad example for the article.

The qmail spec describes queuing and delivery in a filesystem-safe manner.
I've had 2 of these exact interactions, in the London local startup scene, and that was just last week.
You are right, my statement was a bit misleading. These Lua and Python based frameworks call the high performance implementation which is coded usually in C/C++/Cuda/Fortran/etc. Nevertheless the Lua <-> C interface is lightweight and it certainly helps if the overhead is low.

I know a guy who wrote a fast SAT solver in C, though called it with various slow bash scripts. I asked him why he uses bash, he mentioned it doesn't matter. In the end Microsoft's SAT solver beat him, exactly because they cared about such details too.
As a founder you're a magnet for bullshit artists trying to hitch their star to yours, especially if you're seen as 'hot' in any way, shape or form.
Not nearly as bad as an interpreter, especially if you do whole program optimization. In fact, Android switched from the Dalvik JIT to ART, which compiles AOT-ish.
That seems to happen a lot. Every time something gets posted it seems to get down. That said, I'm pretty sure it's just one guy managing it all as a side project, so it makes sense that he wouldn't want to pay for an expensive host for all the traffic he gets.
> me: hi i'm here about the lead developer position

> CEO: cool man lets grab a couple beers

> me: (over beers) hi i'm here for the lead developer position

> CEO: yeah dude but are you any good at foosball?

> me: (over foosball) i'm here for the lead developer position

This is surprisingly common and not just for hiring technical roles. I find it especially odd when founders do it in the process of hiring their first few employees....it's like dude, you don't even have a culture yet, why do you care about culture fit?

It would be impossible to quantify but I wonder how many good ideas tackled by good founders never got off the ground because they were overly fixated on getting the first 10 hires EXACTLY right.