skysight-inc/HackerNews huggingface dataset:
Symfony 3.0 is out Great month for PHP lovers
This website almost certainly violates FDA rules on human subject experimentation because it collects data on the effect of a drug on human subjects. I would stop working on this project until you have advisors (and lawyers) who have experience with regulatory oversight from the FDA. At the bare minimum you are going to need (a) procedures to gain informed consent from trial enrollees and (b) an Institutional Review Board (IRB) to sign off on your trial. Depending on the drug, you might also need an FDA waiver to conduct the trial.

The PhD student (Rob Wagner) listed in the about section should have had at least one course on the responsible conduct of research. This course is required for most (all?) scientists working under a training or research grant from the NIH. Design and implementation of clinical trials--along with the ethical and legal issues involves--is standard fare for these courses for precisely this reason!
THANK YOU for putting "Type 2" in the title. Type 1 and Type 2 diabetes are unrelated diseases. They were given the same name because they have the same symptoms. It is critically important to specify which disease you are talking about in any situation, otherwise you might as well conflate cancer and tuberculosis.
We chose L-Theanine because it has an excellent safety record, is well studied, and has no known toxic dose. We are very aware of safety and ethics. There are many nootropics and supplement companies safely distributing the same L-Theanine.

While we work through our protocol we will continue to dive into ethics and safety.
Putting off an unimportant task to work on an important one isn't procrastinating. It's prioritizing.

The best bit of this essay is the last 5 paragraphs, how to work on big things:

1. Break it down into fun small goals and experiments that get you in the right direction but offer their own reward.

2. Let desire and interest pull you to certain activities at certain times. You're not a computer working through a todo list. Let serendipity happen.

I find having a to do list pushes me to do nothing. The thought of working through it is just too depressing. Letting desire and interest lead me means I'm usually doing SOMETHING. Often quite useful things it turns out.

When I look back over the first 15 years of my career I did my best work when I had no to do list at all.
Show HN: Cartman – a slackbot to remind your teammates to give you input
In that case you can't just store the hash of the password, you will need to password itself.
It was published at one of the top systems conferences (SOSP), so I would presume it's at least somewhat novel. Link to full paper here: http://sigops.org/sosp/sosp15/current/2015-Monterey/printabl...
If you break a light bulb do you destroy light itself? No, you just break a light bulb. Similarly, if someone's brain is hurt, it may not affect consciousness, just the person's brain. People have a closed mind about these things and say words like "obvious" etc.. when it may be valuable to think about things differently or from another point of view.
Indeed it's difficult to tell - exactly the reason why a double-blinded trial on yourself can help you determine if it's making a significant difference or not :)
Interesting idea.. I like it. But why do I have to "Join" a topic group before simply viewing it?
Interesting. I've never heard of someone reacting to L-Theanine this way. Perhaps it could be an allergy?
I love D's community to have their forums also accessible via NNTP.
how would another tax benefit the current economy? How would this tax be spent?
She's received $1 million a month since she started. What does being fired matter after a few months? It's better, in my opinion, to bet big and fail than be crippled by paralysis.
How do you feel about, e.g., the FCC consistently being headed by people who have no experience in the tech industry?
Not yet :( Like Steer said, you can still order Theanine independently of our company but I can let you know when we are ready for international orders if you send me your email!
"there's probably a core function I'm missing to make doing this or that easier"

Would you prefer if there wasn't such a function to make it easier? You lose nothing if there isn't (or you don't know about it) and gain if there is. Why is this a barrier to entry?
> One Nobel winning economic theory leads to an optimal capital structure of 100% debt

Too bad the theory is complete nonsense.

>> The basic theorem states that under a certain market price process (the classical random walk), in the absence of taxes, bankruptcy costs, agency costs, and asymmetric information, and in an efficient market, the value of a firm is unaffected by how that firm is financed.

In short, the theorem states that in conditions that will never exist in the real world, the value of a firm is unaffected by how it's financed.

>> the value of the company increases in proportion to the amount of debt used

First they say "the value of a firm is unaffected by how it's financed", but then: "the value of the company increases in proportion to the amount of debt used", so if "debt used" counts as "financing" then the theory contradicts itself, at least as described by Wikipedia.

This is where I rambled about some other related stuff, but decided to just leave it out because fuck everything about mainstream economics.
Green tea sellers don't make medical claims for their products; green tea sellers don't enroll people in "research".
We're going to keep adding more trials - but there's no timeframe for when you have to start and end the trial. You can order it and start it whenever you receive it in the mail.
Location: Albany, NY, USA

Remote: Yes (I can commute to NYC or Boston monthly)

Willing to relocate: Possibly to Austin if everything is perfect

Technologies: Mobile and Web, mostly PHP/Javascript/Java

Résumé/CV: http://files.pervychine.com/andrei_pervychine_resume.pdf

Email: see CV or use form on http://andrei.pervychine.com/

Spoken Languages: English, French, Russian
My name is Andrei Pervychine, I've been working as a fullstack developer in PHP. And doing side projects with Java for Android.

-----
FWIW, you can import some graphviz diagrams in OmniGraffle and they instantly become beautiful :)

Sadly, osx only I think.
We make no medical claims about our product either - we only reference existing science.
I really hope letsencrypt doesn't delay the real solution - DANE.
His point is that you're giving the VCs indirect access to your sourcecode, not that github would go belly up.
Deploy a Golang (Go) Starter App in Bluemix Using Gin Gonic
Hahahaha, nice! And you people talk about 'freedoms'. When it's YOU practicing your freedoms, it's freedom. When other people practice THEIR freedoms in THEIR places, it's 'tribalism', 'vodoo', and what have you. If you are not of the GLOBAL COSMOPOLITAN CABAL, you don't have rights to your own fking grounds? HAIL FREEDOM!
A good project for a student group though. Ten RPis, ten cards, some scripts to read and write and delete data.
This is not new news, but people really don't want to hear that being fat is bad in the sense of greatly raising the risk of all common age-related disease and reducing life expectancy.

E.g. here is news from 2011, covering a demonstration of reversing type 2 diabetes via low calorie diets:

http://www.bbc.com/news/health-13887909

Note that the diabetes you create through your negligence is not the same as the diabetes you develop by being old and suffering an age-altered immune system:

http://www.salk.edu/news-release/blocking-immune-cell-treats...
Original Huawei B315 4G/WLAN Gateway
Unhappiness at Work
I personally think it gets share with hosts because it never updates anything so it's less work for them to maintain (which I can't hate on).
Logging in Bluemix
You are linking to uBlock Origin ("uBO") -- that filter list is specific to uBO. The other "uBlock"[1] (abandonware) does not support strict blocking, which is what blocks SourceForge.

[1] https://github.com/chrisaljoudi/uBlock
Chennai is experiencing the worst floods in a century. Help if you Can
We're heading in a good direction with turbochargers. I suspect we're getting close to the Carnot limits for gasoline engines [1].

Next steps would be adapting the regenerative braking technology, like that on the Porsche 918, into regular vehicles. There's a lot of kinetic energy wasted in brakes and we're soon going to be able to recapture it.

[1] https://en.wikipedia.org/wiki/Carnot_cycle#Efficiency_of_rea...
I would disagree, but again this depends greatly on the Kickstarter in question and specifically the leaders of the campaign. I think KS would be wise to implement a little more vetting, and maybe require a prototype or something, but truth be told this is something the KS community also needs to get right. On the campaigns I follow I still notice a large amount of people complaining about the waiting which tells me they fundamentally don't understand how this is different than say, Amazon.
I can only apologize - I presume I heard it somewhere and internalized it. Not like I am making fun of Venezuela, at least not intentionally.
Chennai is experiencing one of the worse floods in over a century. Over 260 people have died and the crisis management team is on full swing. But, its a city of over 10 million people. Help anyway if you can. I used the https://milaap.org/campaigns/chennaifloods to make a donation.
But it didn't take months to turn the Apple of those days into the Apple of today.
Parentheses is no a problem if people really want to fix it. We already have JavaScript fixed with CoffeeScript, there's also a chance to fix Clojure with indentation-based syntax, like I tried

https://github.com/mvc-works/parser-combinators/blob/master/...
It's terrible UX. Why do I care that the algo is still running while the window is scrolling? Detect the scroll event and pause the algo. Anyway, it's not fit for displaying a a lot of events, so that should be noted. The resulting diagram is incomprehensible. I'm talking data vis basics here, not being clever. C'mon.
Show HN: Get attention to your project, idea or just some life situation
As an aside: it's a cool idea and worth trying--but you are going to need to make sure that you are compliant with this country's laws regarding the responsible conduct of human subjects research!
It sounds a bit harsh, but the fact that this treatment hasn't been obvious and recognized for some time is an indicator of how unlikely it is for people suffering from T2D to lose weight.
Related: Scott Hanselman interviews Matthew Cannon about making music with the SID...and C64 game programming magic in general.

http://www.hanselminutes.com/498/sid-chips-and-c64-music-wit...
What is very low and very high? I'm not sure my debt/income expectations match theirs so I'm not sure how to interpret this.

Was there data that I skipped over?

Edit: Yes I did miss the data:

> “somewhat high,” for example, then it means that a zip code’s average loan balance is between 25 and 35 percent higher than the national average of $24,271
What you have stated here you have stated in your previous thread announcing doubleblind and presumably elsewhere.
I don't have an issue with what you are choosing, or why.
In fact, it doesn't really matter.

What matters is that you have a clear and transparent ethics approval process, that you clearly state the steps your protocol had been through, and preferably that you submit your protocol to a human ethics review board, and identify that process openly and transparently.

It sounds like you have already developed your protocol, since you are offering your product for sale shipping from the start of this month.
So have you written an ethics proposal? Have you considered submitting it to a HERC? Or are you 'continuing to dive into ethics and safety' now that you have been 'reminded of the importance' of it?

Don't get me wrong, I think your idea and platform is potentially great. But it really seems that you haven't thought about this, and now you're trying to scramble?

If you don't have a science background and aren't partnering with anyone who is, I'd be more than happy to lend my 2c outside of this thread (see profile). Otherwise, I wish you every success with a full and detailed examination of your ethics approach. Medical research (which you are conducting by calling your product an experiment) has a poor history when it comes to blurring the lines between researcher and pharmaceutical company/monetisation, of which you could be said to be doing both at the moment.
Thanks for the thoughts. We've spoken with a lawyer who specializes in FDA issues. We will have informed consent waivers for participants.

Rob does have formal training in scientific ethical issues and is more than competent on the subject.

Also, L-Theanine is something that you can purchase at the grocery store as a food supplement and it has an excellent safety record and no known toxic dosage.

If it makes you feel better, we are a supplement distributor that happens to help you record whether or not the supplements actually work.
2 kinds of plans break away and uni-level. uni-level is easy you get paid x% based on the level someone below you is on. for example you sponsor someone they are on your first level. if they sponsor someone they are on your second level. Breakaway is about group volume the more your group buys the higher your %. But then you pay out your lower levels at there group level. and you keep the difference. until someone reaches a "manager" level where they "break away" and you are paid a % of that group as long as you maintain your "manager" level.
Positioning algo is dumb if it doesn't take UX into account. it should pause while the user is scrolling. Also, it is a futile to suggest that automatically placing labels is scalable for any number of labels beyond 40 or so.
Wouldn't it look more readable if the connectors are straight lines with 90 degree bends instead of curves (like a neatly laid out circuit or wire diagram or tube network).

The current version is artsy. Thanks for sharing this though. Looks very cool.
Trovebox shut down in January 2015 so that equity is worth nothing.
That made me think of Greg Egan's Quarantine:

https://en.wikipedia.org/wiki/Quarantine_%28Greg_Egan_novel%...
Unless something has happened to drastically alter EEG analysis since last I checked, this is meaningless with one electrode. You need at least one other specifically to measure eye/muscle movement, etc.
Sounds very interesting, thanks.
Maybe they are taking the money that people pay him on this side and paying some other research subjects to do the same thing and is going to compare the results.

It's weird to ask people to pay to be part of a study. So maybe that is actually part of what this person is studying.

Maybe all the capsules are placebos and they are studying something else.

Can you tell I like conspiracy theories? :)

Oh I just noticed you are the person who posted this. You should do that, if this isn't what you're doing.
Yeah, 'simple' seems to be much more robust
In modern Java, one uses things like dependency injection (Guice, Spring, whatever) for building up the services, and I find most programmers now abhor setters for their POJOs. Want a new Person object with a different name? Make a new one, it'll be okay, except in the most extreme of circumstances. Ephemeral memory is cheap. When an object comes back from a constructor, it should (in my mind at least) be immediately usable. People also enjoy the builder pattern, I've found. When you call .build(), it will do the internal checks to say if you screwed up, so you're guaranteed to never have a Person with no Organs. This is, of course a run time check so less helpful than a compiler error. Depending on the use case, it makes perfect sense, though.

Also side note, how do I do the code blocks in HN comments like you did?
Testing with expectations – bringing hg's unified tests to OCaml
"Shakes, wobbles and flickers" when user is scrolling while algo is running with 200 points, which isn't a huge number of points if you consider other means of showing time series data. Positioning algo is dumb if it doesn't take UX into account when number of points is relatively large. It should pause while the user is scrolling.

Also, it is a futile to suggest that automatically placing labels is scalable for any number of labels beyond 40 or so. The resulting diagram beyond 40 or so points is incomprehensible. I tried 200, but 50 or 70 would also most likely result in messy diagram.
That's the github project for uBlock Origin.
A Brief History of ISIS
Rate of delinquency seems like it would it helpful map to include. (As I read it, the "Delinquency" map reflects the average size of delinquent loans in the region, so it has a different denominator than the other maps.)
Yeah same, to me it seemed like poking fun at bad OOP practices more than anything, and the last paragraph is just casting garbage collection in a funny way.
Thought I read "lalibela" first :) (Those famous buildings carved out of rocks, a loooong time ago, in Ethiopia https://en.wikipedia.org/wiki/Lalibela)
Don't forget than when they do maintain it they make the UX worse. Every damn time. Over the years it's gone from mediocre to downright horrible.
Is there something notable about the brakes in the Porsche? Regenerative brakes are a big win in many of the hybrids that have been brought to market.
Sometimes sustained reads/writes are a little slower due to RAM size and/or processor speed, but the variations are minor.
11 Android Invoicing Apps for Easy and Speedy Invoicing
i dunno my experience with users in the real world is that software is slow, as slow as it always was and they are frustrated with it now as much as ever.

i'm not saying performance won't go away eventually, but we are not there yet.
I was not familiar with DANE:

https://en.wikipedia.org/wiki/DNS-based_Authentication_of_Na...

Until the CA system is completely abolished, this appears to works great with LE -- free certificates and a guarantee that no other CA can impersonate you.

The ACME protocol could conceivably be extended to update SRV records along with the certificate for some DNS providers.
Three-quarters of women suffer from stress-related anxiety
All those numbers were under 0.1 MB/sec, and I gave up on the 4K tests after they were running a couple hours. Excruciating!
Really like tornado for Python web apps. Simpler and lighter than Django, and with support for websockets too. And you can build generic TCP servers with it too, just like Twisted.
There IS known max energy, it's called Planck scale (https://en.wikipedia.org/wiki/Planck_scale).
In short, the theorem states that in conditions that will never exist in the real world,...

If only Modigliani and Miller weren't total idiots. Then they might have repeated their calculations with these assumptions relaxed.

First they say "the value of a firm is unaffected by how it's financed", but then: "the value of the company increases in proportion to the amount of debt used", so if "debt used" counts as "financing" then the theory contradicts itself, at least as described by Wikipedia.

If you bothered to read the article, you'd recognize that Modigliani-Miller actually did the exact calculation you previously criticized them for not doing. Similarly, if you read it, you'd recognize that the claims you think are contradictory actually apply to different circumstances (taxes vs no taxes).

What next, medicine is contradictory because "if you don't eat cyanide, you probably won't drop dead, but if you do eat cyanide you will"?
I never thought about this, and google searches just confirmed, but a person can have type 1 and 2.
Here's a summary and commentary of the paper from Adrian Colyer's 'important/interesting CS papers' review blog: http://blog.acolyer.org/2015/10/23/vuvuzela-scalable-private...

"The cost of running a Vuvuzela server on AWS at current prices is about $10K/month, dominated by bandwidth usage."
Great post. Settings the bar too high is something I've seen many times. It's used as a way to give the illusion of collaboration and meritocracy if only you can prove something that is, in reality, out of reach.
From WebMD: "Holistic medicine is a form of healing that considers the whole person -- body, mind, spirit, and emotions -- in the quest for optimal health and wellness."

There are doctors aboard the woo-woo tinfoil hat train, for sure, but from what I've experienced it's more of a trend towards going "Huh, so you're not sleeping well, let's see if that might be caused by stress in your life or lots of coffee in your diet" instead of going "Can't sleep eh? Here have these drugs!"
Best-case runtime = 1. Worst-case = infinity.
I keep seeing more cars with tiny engines and turbos, which have decent performance and very good fuel economy.
Case study: building a marketplace with ads aggregation
Does anyone know how this compares to ChucK?

https://en.wikipedia.org/wiki/ChucK
for the record: bitmessage also has this kind of metadata & data privacy
THE queue is perhaps a thousand people long. It snakes around the dusty, rubbish-strewn back lot of a giant supermarket in the heart of Caracas, Venezuela’s capital. ... “I came here for milk,” says a young mother from El Valle, a working-class district a few kilometres to the south-west. “In El Valle, there’s nothing.” She is carrying a tiny baby, while her four-year-old daughter helps with the modest purchases she has managed to make. Today the Bicentenario has sugar, maize flour, chicken and toilet paper at giveaway, government-controlled prices—but no milk. It is 9.30am and customers who began queuing at six o’clock are just emerging. Hundreds more wait outside a narrow gate in the 3-metre-high railings around the lot. Uniformed police keep order; most customers seem resigned rather than belligerent.

http://www.economist.com/news/americas/21640395-government-o...
They could have been 500px, if Flickr was addressed in time ( or just left as an incubated project instead of forcing integration, see http://gizmodo.com/5910223/how-yahoo-killed-flickr-and-lost-... ) - and maybe not with a sync-up-everything-on-first run android app.

They could have been a lot of things but they managed to smash every potential idea with the tight, corporate-wide integration.

They still have the Yahoo! Finance, which I believe, is without competition. Focus on that, stay ahead of competition, if all the rest if falling apart anyway. And start killing the rest of the services which are making less and less money.

As much as I dislike the decisions Google made with dropping the Reader, Labs, etc., I understand the reasoning, and that is what Yahoo should have done as well.
Freecycle for food – OLIO launches in London today
Hindsight is always 20/20, isn't it?

This is an easy assessment to make, to say she didn't do something risky without considering that something risky would have a big chance to fail spectacularly.

The comparison to Apple is particularly interesting. Before Jobs came on board, many people suggested Apple to ditch the hardware business and focus on software, like Microsoft did. In the end, Jobs came in with the unheard of idea of building attractive hardware. Who would have anticipated that?
Sorry about that; all are 16GB except the 32GB Evo+, and 8GB Kingston and SanDisk Extreme Pro.
Epson unveils world’s first in-office paper recycling system
Yes, this is painfully true. Excellent comment.

But is there a good way to overcome this, and convince cautious, quantitative managers that an decision with no corresponding data is truly necessary, and could yield great returns?
Microsoft PowerApps and the Raise of the Personal Mobile Business Apps Platform
Cool idea, but as many have pointed out there are some potential issues with the execution.

I'd suggest you get an additional formal legal opinion on applicability of HIPPA as well, it would be financial painful (up to something like $250k/record if I recall correctly) for you to get caught on the wrong side of that one.

You should also (already) have a proper formal ERB.
The downside of carbon tax is that it harms developing nations and the poor the most.