skysight-inc/HackerNews huggingface dataset:
Biotech is certainly exciting on the cost front as technology progresses, however, there is an even easier win which is bringing price transparency to supplies and reagents.

We've worked with every YC biotech company (except Ginkgo) and the savings is massive verse paying list price. Startups are unable to negotiate competitive prices from large distributors due to their limit budgets so we've been pooling their purchasing power.

Recently, we've started doing analytics (http://labspend.com/) for labs on supplies/chemicals and see huge differences even in universities that spend 10+ million per a year.

Here is an example from four universities located in the midwest of the USA for a commonly used chemical reagent called acetonitrile.

List price for this item is currently at $1335.49 (http://www1.fishersci.com/ecomm/servlet/fsproductdetail_1065...) and here is what university labs are paying $399.31, $239.16, $220.54, $156.10 - image: https://dl.dropboxusercontent.com/u/7671582/chemical-pricing... ).

We commonly see 10x savings, but even in this example 5x can be quite significant in the budget of a start up.
Johnny can't even select, download, use, or configure an email client.
Stop minimizing things you have accomplished. You think everyone started off at the top. Look at each project or task you completed as a stepping stone to the next and to become better..

Simply put.. Don't try to copy the Jones's.
Is this a social commentary joke? It must be.
Wow, that's quite a history.

There's more detail on the Battle of May Island here https://en.wikipedia.org/wiki/Battle_of_May_Island

The damage on Fearless, which sunk the K17, gives a little insight into the pandemonium
http://www.rfyc.org/wp-content/uploads/BattleMayIsland_Fearl...
Rumblr: Meet. Fight. Conquer
I would like to understand why the word beggar is not equivalent to the word pan handler..

for some reason my brain is not making the jump here.

Is the word bum equally offensive?

Is pan handler preferred because it sounds like more skill is required? what about if there is no tact or pitch and someone is just begging for food?

my brain seems to think all variations of this act are not things you would want to be called, despite if your engaged in it. but is it not calling an apple an apple?

just curious, not disagreeing and would like to know more, thanks
I was mistaken by "some browsers", it seems that actually only Firefox nightly has it enabled at the moment: https://developer.mozilla.org/en-US/docs/Web/JavaScript/Refe...

So yeah, not good enough to be used in production.
You know how if you're stopped at a light and clean the windshield, the washer fluid sprays, the wipers cycle, and then there's some drips of washer fluid at the top of the wiped area that then drips down the windshield so you have to manually trigger the wipers again? My old Saab had a delay built in to the call for wiper fluid so that it would automatically sweep the wipers a few seconds to get those last drips. It was but one of many thoughtful design elements.

Saabs had a character that was unique; regardless of how one felt personally about driving one, the auto world is poorer place without Saab.
Proper archive version: https://archive.is/nlKS
It may be worth noting (though it doesn't change any of the science) that this is from 2012.
The inquisitive gender studies student and Sheryl Sandberg
I find using name-spaces in imports makes the code a hundred times easier to reason about.
Small businesses with revenue of less than 100K a year* can opt-out of VAT registration hence will not charge VAT and thus cannot generate you a VAT invoice.

And as far as "marketplaces" go the HMRC's own website says that you can use 3rd party websites to actually ignore the VAT MOSS requirements as the site's operator should handle it for you.

https://www.gov.uk/government/uploads/system/uploads/attachm...

While there ofc is a way for marketplace providers to throw the liability back into the hands of the small business which uses them I have a strong feeling that neither Amazon nor eBay make it particularity clear or advertise it, add to that the open endorsement that HMRC and various small business "associations" gave marketplaces as a easy tool to reduce the VAT burden on small businesses and you might have quite a few instances of unintentional "fraud".

*I'm assuming since you are commenting on a UK specific issue you are in the UK if you are not there might be other regulation or different caps for small businesses to opt-out of VAT.
well that's the key at the moment there isn't too much shame in doing so, I expect there will start being some soon.
While I see why you think "Because it's their choice." isn't very helpful, I would say there some truth to it.

People in technology seem far more willing to accept to accept "worse" conditions and just generally less aware of technology as an competitive industry compared to other people in their respective industries.
We've had mixminion[1] around for years, which handles backwards compatibility with aplomb.

[1] https://github.com/mixminion/mixminion/
Fight Club ... has changed.
I wonder if someone has gone through the trouble of converting that monster into LaTeX.
"If you knew that fraud was being committed you are liable," she added.
"If you should have known that fraud was being committed, you are liable
as well."

So I hope you informed the proper authorities promptly!
The article doesn't make the claim that it's her most employable asset, it's highlighting a trait that's visible from her page requesting donations, and would potentially remove the need to seek donations.
I really hope so. If it is, the creator needs to drop better hints because clearly the absurdity of the concept in and of itself is going to be lost on most people, as the VentureBeat post demonstrates.

The registrant email associated with the getrumblr.com domain is me@jackk.im. jackk.im is the website of Jack Kim, who lists himself as the co-founder of OneTune.fm, a current Stanford student and former founder of Benelab, "a web-based nonprofit startup dedicated to harnessing the immense power of web search to fund incredible causes."[1]

[1] https://www.linkedin.com/in/jack7kim
Great course. I really got strong footing with ChucK over that ~2 month period.
https://soundcloud.com/kadenzeofficial/sets/student-portfoli...
Won't the extreme similarity to Disney cause problems?
>Man, the creature who knows he must die, who has dreams larger than his destiny, who is forever working a confidence trick on himself, needs an ally. Mine has been tobacco. —John Boynton

That's an incredible quote. Thanks.
I thought we were not supposed to talk about fight club.
Oh, so it's political. Never mind then.

(If it is not political, I still would like to see the answer.)
What about meta clutter like yours, or mine?
Duelling

71. Every one who
(a) challenges or attempts by any means to provoke another person to fight a duel,
(b) attempts to provoke a person to challenge another person to fight a duel, or
(c) accepts a challenge to fight a duel,
is guilty of an indictable offence and liable to imprisonment for a term not exceeding two years.
R.S., c. C-34, s. 72.

Criminal Code of Canada.

http://laws-lois.justice.gc.ca/eng/acts/c-46/page-24.html#h-...
Honestly the best bang for the buck would be to buy decent power amp. Then find good cheap old speakers from Craigslist or something like that. Speakers often outlast amps, which brings the price down. I just had to give away perfectly good three way pioneer speakers for free. Speakers do wear, but not linearly. They are first like new until they are completely broken.

When you have speakers and amp, room acoustics is the next thing. Start with curtains. Clap your hands, if you hear disturbing echo, add something soft.

200e for amp, 60e for two used speakers and 40 for nice curtains. 300e total and you might have better audio than someone who spent 1000e for surround home theater.
I have great respect for Garry Tan. However, I find the key quote on "how profitable Hollywood can be at best" a bit strange, and want to correct his statement below based on specific data. Here's the quote "...11X return on capital. That's the highest grossing film ever made, and a good proxy for how profitable Hollywood can be at best."
Since 3,800X return on capital for Peter Thiel's FB investment is an obvious outlier/best case scenario, let's compare apples to apples and take the best case for Hollywood-type investments:
"Paranormal Activity With just $15,000, the visionaries behind this project created a movie that took in a worldwide gross of almost $197 million." That sounds like 13133X return to me, which is even greater than 3800X...
See http://www.businesspundit.com/10-most-profitable-low-budget-...
Rule #1 of fight club is, don't talk about fight club.
If it is real, it will surely be crushed under the weight of lawsuits.
> I maintain that in the not so distant future, someone is going to write a math-search engine (or at least they should)

I think this is one of those things that has been in the not-so-distant future for longer than you'd think. See [Mathematical knowledge management](https://en.wikipedia.org/wiki/Mathematical_knowledge_managem...) for a general overview, and [OMDoc](https://en.wikipedia.org/wiki/OMDoc) in particular. This mathematician-but-not-expert-in-this-stuff particularly associates [Michael Kohlhase](https://en.wikipedia.org/wiki/Michael_Kohlhase) with research in the area.
Hypersonic engine could 'revolutionize' air travel
The upkeep on them (parts, repairs) is quite expensive compared to your average japanese auto.
Device and even host are quite common in the Windows world:

https://msdn.microsoft.com/en-us/library/windows/desktop/aa3...

Volume = Device

Or Microsoft's UNC path:

https://en.wikipedia.org/wiki/Path_(computing)#Uniform_Namin...

\\ComputerName\SharedFolder\Resource -> \\host\device\path
With JavaScript (nodejs)

var lightsOn = true;

setInterval(blink, 2000);

function blink() {
var fs = require("fs");

fs.writeFile("/sys/class/leds/beaglebone:green:usr0/brightness", lightsOn, function (err) {
if (err) throw err;
});

lightsOn = lightsOn ? false : true;

}
.. on a correctly set up beaglebone, not other systems. It would be much better if this were in the title.

On most embedded systems and FPGAs faffing with the toolchain and hunting in the documentation is 99% of the effort of getting an LED blinking, that's why it's used as the embedded 'hello world'.
Well that just makes me really want to fight some Canadians.
The founders already went public with the information in this interview with CBS 5 Phoenix. Matt Henderson and Jack Kim, New York City.

http://www.kpho.com/story/30460494/app-connects-strangers-wh...
I was really excited when I first read about bitmessage. As far as I can tell, it solves more problems than any other messaging protocol. It's a mystery to me why is doesn't get more attention.
> I simply despise regulation and entitlement.

And I like civilization, which has a foundation partially of regulation and entitlements. Perhaps Somalia is more to you're liking?
>I can't do that.

If you know enough programming to write a IRC bot I think you can.

I'm sure you'd figure out how to get data out of some Access like tool - eg. ERP system with tool to build custom query/reports, and I doubt you would have a hard time writing excel formulas with conditions and such.

Seeing how you used python if you found a script online that say converted some files you would know how to run that.

I'm not saying everyone needs to be a programmer but knowing the basics actually enables you to use computers much more efficiently and considering that computers are used literally everywhere nowdays it translates to productivity and real world problem solving.
The danger of a single story
I know this is a trivial response to such a thoughtful post, but what is "the lion book"? Do you mean The TeXbook (http://www-cs-faculty.stanford.edu/~uno/abcde.html)?
I've found that if you're savvy enough, you can adopt habits that deal with low bandwidth situations well. I would drop metered plan in an instant if I could just have an unlimited symmetric 5Mbps. That's enough to gradually download libraries of 1080p video. It's not enough for real time, but real time isn't necessary, even when companies insist that it is.
Advertising and motivation I guess. You get to promote yourself (or in case of a group from an organization) as doing "good things", and putting it out there forces you to go through with it, because otherwise you look bad to all the people you told about it.
There's one born every second, eh?
Do you have any experience with cSound ?
ChucK is kinda hard to make a wrapper for.. So you have to run it parallel with other controller or audio workstations... At least as far as I've learned. But I've only been into ChucK for a few months.
I also think that one should be ashamed of a typesetting solution that requires so blatantly lying about the semantic meaning as to pretend that the base of an exponential is a subscript.
For anyone wondering how this is possible: by violating fire code. He says he, then he and his wife, then one or both of their children were sleeping in the closet. I'm not familiar with the language of the California Building Code, but in the 2014 verison, volume 1, chapter 10 gets into the limits. The closet is not a "sleeping unit": it doesn't meet the 120 sqft minimum, doesn't have a wide enough door, and doesn't have two methods of egress. There's probably more I didn't find.

I know this seems like tedious legal nitpicking and the main apartment room is right there and "everybody does it", but nearly every line of fire and building code exists because of a preventable tragedy. Even if it's not against the lease it's unsafe. (And he built a barely-braced lofted bed in an earthquake zone!?)

The author happily compounded the rent they saved every month but failed to compound the increased risks they took every night.
This give me an idea: Grumblr. It's like Rumblr, but for gay fistfights!
Prior discussion on YC + biotech: https://news.ycombinator.com/item?id=9997722
> 3. Create value for [...] people

Why isn't this higher on the list? I suspect there's far more people quietly kicking ass than making it by being a "personality" via their blog/podcast/twitch/whatever.
This idea was proposed in a popular reddit/4chan post a year and a half ago: https://www.reddit.com/r/4chan/comments/2ccixc/anon_has_a_st...
Dumb Cuneiform
Coliving: A Solution for Lonely Millennials?
Apparently it's a British term: https://en.wikipedia.org/wiki/School_run
Not exactly because you can combine as many questions as you like and get an answer about whether one of them or all of them is correct, furthermore if you can ask question in first order logic, like "for all x is y true?" as opposed to just "if x then y?" The wording would be come awkward very quickly but you can gain an almost unlimited amount of information from compound questions. I wouldn't be surprised if there were a solution to this problem involving only two questions or even one, though at the moment I don't have the time to work through it so don't take my word for it.

In binary terms, let's say you have one bit, 0 or 1 that represents a single propositional statement, "x or y" or "x and y" but with compound questions you can get as many bits as you want "(x or y) and (x and y) and (p and q)" so you can only ever get the truth value of the entire compound statement but you get far more than a single truth value
What's the legal definition of 'duel'? Is it any kind of fisticuffs? Pistols at dawn? How do martial arts schools operate, then? Is 'half-strength' sparring allowed? Full-strength?
They should call it social non violent fist interaction.
And in Haskell (feel free to include this):

import Control.Concurrent (threadDelay)
import System.IO

main :: IO ()
main = withFile "/sys/class/leds/beaglebone:green:usr0/brightness" AppendMode go
where put h s = hPutStrLn h s >> threadDelay 2000000
go h = let m = put h "0" >> put h "1" >> m in m
https://news.ycombinator.com/item?id=10526596
What about the chilling effect? People change their behaviors when they know they're being watched. It goes completely against the spirit of the US Constitution. How can I pursue happiness if I'm worried that what I write will be a liability in the future?

EDIT: grammar
They've also never built a car before
and get Indian food in Britain
That just means they'll call it the "Uber of fighting" or something equally silly, because it's so super subversive.

I kinda hope this is real, just because I'd like to watch the can of worms unfold.
Washington State law allows for mutual combat. Police will even referee. https://www.youtube.com/watch?v=3bRp2-ihx10
UBeam Declassifies Secrets to Try to Prove Wireless Power Is Possible
The funny thing about depictions of ISIS' areas of operation and control on maps provided by, say... The New York Times, is that they're always shown as wispy red tendrils curling along main highways and around towns, and that level of spin is a bit silly.

The point being that there's some sort of psychological effort being made, to assert that while all the main roads are under control, and all the main roads certainly surround much larger areas, ISIS only controls the first 25 feet outside of the roadway, as if it's bound by some sort of municipal Iraqi or Syrian zoning ordinance.
...if your Linux base port has the chip-specific GPIO driver wired up correctly and is enabled in the kernel along with the sysfs interface.
> That's the kind of situation that GoFundMe and similar sites are for.

GoFundMe's website would disagree with you on that. And I don't think asking for money even if it is not an emergency is necessarily bad. And if people want to make an ass of themselves, well, now they have a new avenue to do so.

The juxtaposition of all these things on one site is weird though, I agree, and it would be bad if it stained the reputation of the "better" causes. A site specialized in "emergency" funds certainly could look more respectable and potentially add more value as a community. But would process less funds and make less money...

And that's not getting in the whole "privatizing risks that should be caught by society" (or not) discussion...
People frequently die from fist fights which lead to second degree murder charges and anywhere from a few years to 20 years to life in jail depending on the state, the judge and past criminal records.
The Case for Melancholy
Yes, that's what immediately came to mind.

To be clear, it was originally posted on 4chan (in their tech board, http://boards.4chan.org/g/), then a screenshot of it was later posted on reddit. Calling it a "reddit/4chan" post confuses things.
What I'm getting from this is that you don't know your "friends" particularly well. How do you know how well I know my friends?
I'm not sure about how large (or how solid) the majority that support Christiania is, most Copenhageners seem divided on the issue.

Cannabis is de facto legal in Christiania: people buy, sell and use it openly there without repercussions. This seems to be widely regarded as a good thing.
IBM is trying to solve all of computings scaling issues with 5D electronic blood
This Matt Henderson[1], who is the "Chairman & Chief Executive Officer at Juhász & Associates, LLC", "a digital branding agency passionate about genuine and sincere human engagement," has been retweeting Rumblr's Twitter account. You really can't make this stuff up.

I wonder if the founders are going to eat their own dog food. By the looks of their photos, I'd guess not.

> “We're kind of all hands off after people meet,” said Jack Kim, the second half of the Rumblr duo. “Beyond that we don't condone any specific type of violence and we do specifically state when you sign up, we're not legally supporting any of what you're doing here.”

This is perhaps the best proof yet that you can get into a school like Stanford even as an idiot.

[1] https://twitter.com/juhaszhenderson
Personally, I think Linus can be a crotchety old bastard all he wants and people can take it or leave it. Kernel development isn't supposed to be an all-inclusive club where everyone gets a big welcome hug.

That said, this "it rails against code, not people" stuff I keep hearing as justification is a complete bullshit cop-out. When Linus calls your code "complete idiotic crap", "compiler-masturbation", and says "I don't ever want to see that shit again," these are not merely attacks on code. If he's calling your code idiotic crap, he's calling you an idiot. If he's calling your code masturbatory, he's accusing you of compiler-masturbation.

Trying to dismiss it as "attacking the code" just opens the door for pretty much any level of unprofessional abuse as long as it's couched in terms that make it technically "about the code."
Not if the receiving smtp server implements DMARC
Supermin[0] is another really cool tool that might be interesting. Though I still can't exactly tell if it's relevant.

[0] http://people.redhat.com/~rjones/supermin
Well, I have learned about:

- Network configuration

- backups(rsync)

- Server monitoring, crontab for schedule tasks

- Troubleshooting (I used to hate so much trouble that I found, but I learn to love this and I like to solve problems)

- ssh

- Web (Apache, nginx),Dns,DHCP server's installation and configuration.

- Basic use of iptables

- Installation and configuration of software.

- User management.

- Containers like chroot or systemd-nspawn.

- Possibly other things, but I don't remember right now.

I was in a project at my previous work where I could put on practice all of this knowledge, we began installing Debian from zero (Without gui), partitioning the system with lvm, using chroot to build containers, installing other software inside that containers (Like RethinkDb, GlusterFs) and configuring Clusters. After that all the process was ready and tested, we automate it with bash scripts.

In my personal computer i use Debian and i do all the configurations and labs in the terminal, the true is that i like so much to work in this environment. I am improving my knowledge in Linux, so right now i am doing this http://www.linuxfromscratch.org/.

That is, i am not a senior Linux Administrator, but I've done well in my previous work. If you would like to know more or have another question, just tell me!
Do you have to have insurance before fighting in case of a beat down or broken bones? Are the fighters checked when they arrive for a fight to make sure there isn't a knife, gun etc.? And what exactly is a casual fight?
I suppose the article could be succinctly summed up as "ignorance is bliss." Also, it's somewhat ironic that this is in The Guardian.
Now that I think of it, at least four people I know have some sort of divorce or estranged-parent thing going on with their last names, and I never would have been aware of it if not for the mismatch between the name I met them under and the name on one of their online profiles.
Why would you need this and how big is the budget?
frequently?
The consumer Rift is coming out next year. So far they have only released development kits.
Predecessor of CoyoteOS and its famous BitC language https://en.wikipedia.org/wiki/Coyotos
No one has it all together. Ever. Full stop. So quit worrying. Do -> measure -> adjust -> repeat. Most people don't peak professionally until they're in their 40's.
Books probably don't influence people's understanding of history all that much. It's pretty unusual for people to read nonfiction at all, much less history.
Thanks. This does make sense. Was trying to figure out if I should be using them when I tweet out a link. Seems like the value is more about when you hand off the link to someone else.
I'm also excited about my first comment with 4 upvotes :P
To bad theres no GPGTools for iOS. And the chances of Apple opening up the mail client for it is slim. Also, the licenses could be a problem?
Who chooses the editorialized title? It can't be the submitter; submitters aren't supposed to have a privileged position.
A Return to Form
Ben Carson's home decor: an homage to himself