skysight-inc/HackerNews huggingface dataset:
Definitely a really cool project! I have had the privilege to collaborate with an immuno-oncology group at Dana Farber a few years back, and they're perpetually on the top of their game, and at the edge of human knowledge. Based off of this article, there is a lot more work to be done, though:

"But statistics — not anecdotes — rule over drug approvals. In 2005, regulators in China approved an oncolytic adenovirus called H101 to treat head-and-neck cancer, after evidence showed that the treatment could shrink tumours. Those trials stopped short of assessing improvements in patient survival — a measure often required for FDA approval. Since then, a medical-tourism industry has built up in China for people who cannot get the therapy in their home countries.

Then, in May this year, a team supported by biotechnology giant Amgen of Thousand Oaks, California, published promising results from a large clinical trial of T-VEC (R. H. Andtbacka et al. J. Clin. Oncol. 33, 2780–2788; 2015). The virus both shrank tumours in people with advanced melanoma and extended patient survival by a median of 4.4 months. Yet statistically, survival benefits fell just a hair’s breadth of significance. “That raised the question, ‘Well, what is statistical significance? Is this an active agent or not?’” Russell says."

It's possible that a more immunogenic (eliciting immune response) virus would have better results against cancers. Of course, this means that it would also hurt the patient more. I'm sure they know this already.

Though I'm biased, I think that given the current state of viral engineering, immunotherapy (immune cell gene-engineering and transplantation)is a better way of getting at cancer for now-- it's rapidly being proven in the clinic and the lab. I can see a time 10 years from now where we'll be able to engineer certain viruses to be powerfully oncolytic, but for now I think the problems are specificity of targeting (you only want to kill tumor cells) and the inability for prototype oncolytic viruses to infiltrate the tumor microenvironment. The infiltration problem isn't a hard dead end, nor is it a problem unique to viral therapies, but a couple of the bleeding edge immunotherapies and even older radiotherapies and chemotherapies can pierce into the tumor microenvironment with no problem.

Though I expect immunotherapy to beat them to the punch, I can completely see oncolytic viruses joining the combination regimen that is the standard of care, alongside surgery, chemo and radiotherapy, provided that they show a more concrete improvement in survival rate/length.
$2.7 billion blimp on the lose.
You might want to obfuscate the last 4 digits of your credit card in that screenshot given how useful it is for hacking other systems.
Npm's growth rate of top 1k packages
Cal State professor reprimanded for refusing to use expensive textbook
This was a fascinating read. Surprised that painters have seemingly good working conditions, set their own hours, and work from home!

Just a random idea: when targeting mid-market customers, have you considered going "Watsi" style? Instead of an Instapainting storefront, what about commissioning artwork directly from painters? Display the painter's name, their photo, number of previous paintings painted, and their affordable price to commission a painting.

Effectively, you could become the Internet-version of those studios themselves.
Why not? I've been impressed with his leadership at FB. He's more mature than I would have expected, after the first few years.
Assuming you've checked https://angel.co/jobs and http://workinstartups.com/?

Other than that, I know of converge who're growing last I knew: http://converge.io/

If Bristol's not too far, then http://ultrahaptics.com/careers/ or get in touch with my consultancy - we're doing connected product development: https://zoetrope.io
Because xxx.onion is essentially hostname. One can conceivably have https://example.onion, ftp://example.onion, telnet://example.onion, and so on.
> I know it's contrary to the literal meaning

Also contrary to reality (source: me, being Swedish), and logic; A retailer will hardly refuse to accept cash (although buses do refuse cash to avoid the risk of robbery), while you might avoid buying if you need to handle cash.
Yeah, it looks the same with little tweaks. My question is did those magazines feature flymaids as they are stating?

EDIT: The site looks the same and that is a clear fraud hence my question.
I live on the border of a tax-free state (New Hampshire, live in Maine). When a car is purchased in NH, the sales taxes are assessed at the time of the auto registration (5.5% in Maine). No sales taxes are lost to the state.
Indeed, with python i can program fastest, but whenever something gets big you had wished i programmed it in golang. However, its still a valid choice to choose python initially. It depends
The reason it has to be done at the DNS level, rather than at the URI scheme level, is because any protocol can be routed over TOR.
Yeah, his expiration date (if correct) is on there too.
It seems that you are under the impression that the license can determine whether or not something that uses or interfaces with some program is a derivative work of that program.

That is not the case.

The answer to whether or not X is a derivate work of Y is the same regardless of the license of Y. It is answered by looking at how much of Y's copyrighted expression has been incorporated into X.

All the license of Y determines is whether or not, in the case that X is a derivative work, that making or distributing such a derivative work is allowed.

Some licenses have contributed to confusion over this by using terms like "derived work" or "derived from", which people confuse with "derivative work".
mtanski "you should really rent the car for a couple days." Exactly!

This what we do when we are car shopping. Normal cycle is to start looking when the existing car hits the 8% mark in unscheduled maintenance (or 150K miles) (your percentage may vary). Once we close in on the model we like we find a rental and drive it for a week. If it passes we find a dealer, get the model and what we want on it and then shop that info around between multiple dealers in the area.

We never use the existing car to trade in since most are 10 years old and have lots of mileage on them. When we pick up the new car we will offer it to the dealer as a trade and decide at that point if we want to sell it to them. Last cycle the dealer said he would give us another $200 off the deal if he didn't need to take the trade.
Holy shit. SCROLLING. This is technology. This is why I became a coder. To bring this to the world.
#disruption
I've being collecting number of dependencies for the most popular packages last month. This visualization shows the growth rate of those packages.

Make sure to drop an mp3 file on this visualization to see an Easter egg :).
Good point. I hate that word "resource" as applied to people, but I say it all the time, because everyone else does -- not a conscious choice, just a bad habit.
The economics of framing are tricky too. Frames are actually just as cheap in China FOB price, especially if they are a mass-produced size. Even if not mass-produced, a frame from China would be priced in line with a custom painting.

The issue is that shipping prices are by weight, and the frames are usually much more heavy than a piece of canvas. This significantly drives up the total price of a frame from China, and lets American framing companies charge much higher prices.

Pro tip: get the artwork in a size that already fits a standard frame size and you'll save a ton of money.
Seth Godin talks about Dafen in a bunch of his books. There is an entire section of the town that just makes monkey paintings. My favorite anecdote is about one of his monkey paintings that inexplicably has what looks like a teardrop on it. He said he was confused about this for a while, but then realized what must have happened -- some rain got on one of the paintings, and from then on everyone just kept copying the smudge. (Part of a larger riff about how not everyone who makes paintings or whatever is an artist.)
You've tied yourself in knots here. "Vast uncertainty" about effective dates of regulations is worse than those regulations' direct effects on consumers who would like to purchase products? Worse according to whom, the Government Printing Office?

As other comments in the thread have made clear, the "research" has been done, and the ancient lore of how automobile sales were different from every other aspect of the economy a century ago has been rejected.
> I never said that charter schools was performing better I was saying that my SONS school was performing better despite being a lottery.

Your comment started with "Again this is simply wrong", without specifying "this".

I assume you were refering to: "[charters are] selecting or quasi-selecting their student population".

So, my interpretation of your claim: "Charter schools that use lotteries out-perform, which means their performance is not attirbutable to student selection."

My response to this claim was that lotteries are a form of selection bias!, and that lotteries are exactly what I meant by "quasi-selection".

> Please argue against things I have said instead of things I never said.

I did respond to the substance of your comment. lotteries == selection bias, so a lottery school performing well isn't a sufficient answer to the problem of selection bias. (Also, if you don't want people to mis-interpret your comments, then don't open your comment with a dangling antecedent... saying "this is simply wrong" without saying what "this" is, is literally inviting people to interpret the thing to which you were referring.)

In other comments you've narrowed the scope of your claims to something about your child's specific school. If that's your intention, then Im not sure why you stared your comment with "this is simply wrong" when I clearly wasn't referring to your child's specific school, but rather was very clearly asserting a general statistical truth that applicable nationally and even internationally, regardless of the vagaries of a single individual event.

2. The back half of my comment was essentially: whether or not lottories are a form of selection bias, it's never-the-less the case that charter schools sometimes aren't evaluated in the same way as public schools, making it impossible to actually evaluate public vs. charter -- which is the central thesis of my comment.

> it's not immaterial whether someone can put their kids to a public school in Tribecca vs. Harlem.

Me: The charters vs public national comparisons are skewed comparisons in general because they're not being evaluated using equivalent metrics -- huge huge problem! Also, selection and quasi-selection bias.

You: Lotteries != selection bias. And there's another compounding variable -- income of student's parents!

Me: Lottories == selection bias. And yes, income or whatever is yet another thing we should control for when comparing public to charter. But in addition to controlling for these other variables, we need to -- at a minimum -- compare based on the same metrics. If charters don't have to take (the same) standarized tests, then controlling for every other variable in the world is pointless.
According to the article, no.
Yeah, but drinking's super fun so who cares?
Statistically your worse off owning a gun. The odds of a member of the general public using it for defense are lower than the odds a gun they own will end up killing them.

Nope, that can't be the statistic you're thinking of, since the "in defense" is well over a million annually (first survey, by gun grabbers, did not count how many times per year) to well over 2 million (later studies focusing on this). Obviously a bare, bare fraction of gun owners are killing themselves with their own guns (you only get large numbers including suicides, and guns clearly aren't significant in that: https://en.wikipedia.org/wiki/List_of_countries_by_suicide_r...), let alone by losing them to criminals in combat, which is very rare.

You're probably thinking of the Kellerman study, which scored successful self-defense uses only as killing the criminal. Which is not even a legal objective, lethal force to stop is, to kill is reserved to the judiciary. The vast majority of gun self-defense instances (like > 80%, maybe 90%) don't even involve a gun being fired.

Getting back to our topic, I get the strong impression that the statistics produced by the RIAA et. al. are as bad as those produced by the gun grabbers. Except they don't get published as Revealed Truth in the NEJM, JAMA, etc.
My old Homejoy login doesn't work on that site, and doing "forgot your password" gives an error of "user does not exist" for the email I used with Homejoy.
Identity Guidelines [BYU]
See Congress polarize over the past 60 years in one chart
I've had my current MacBook Air since February 2014 (so ~1.7yrs) and its cycle count is a mere 75. Granted, most of the time I'm using it with AC connected.
The dynamic there is that there's little incentive to replicate results - no journal is going to publish an article based on that. Why spend your time and money on that then?
All these languages, Go, C++11/14, trying to be as concise as Python.
Just look at those slice examples. At least C++ is playing catch-up. With Go there is no reason it had to be worse than Python right out the gate.

https://gist.github.com/ericfrederich/c8d8513b9790106d87b7
Release, we have
Anyone want to share what you're working on?
EV certificates add green buttons with company names. Registrar checked that this company indeed exists and legal. So you can be sure, that you didn't mistype URL. And may be some users are comfortable with HTTPS scheme.

Another concern is that major browsers might obsolete HTTP scheme, so their UI will warn user about insecure connection. I'm not sure whether browsers will be able to distinct between onion sites and regular sites in that aspect.
HN Guidlines: Please submit the original source. If a post reports on something found on another site, submit the latter.

It's right there in the very first line. As a general rule, very little that comes from Slate, Salon, or the Huffington Post is original content.

https://www.insidehighered.com/news/2015/10/26/dispute-requi...
>Conspiracy theory would probably speculate on some new tech being demoed or tested over Baltimore.

It says it right in the article:

"It's currently on a three-year test run to see if it can help detect cruise missiles or enemy aircraft from 10,000 feet above ground."
Try this http://www.forecastwatch.com/

I once bought data from them for couple of hundred dollars.
They may still be compliant and storing your credit card responsibly, I would assume they used Stripe or similar and they're only sending the last 4 digits back over standard http. If they're allowing you to add a new card, then there's an issue.
I can just say with that attitude there is going to be no public acceptance of nuclear power.
and as a result it's pretty much forbidden at many places.
Looking like they sold their customer data over to fly maids or whoever was behind them. Surprised they were able to actually transfer the CC info. When I was at a company that was selling off assets, the most we could do was give them customer email addresses. I have serious doubts about the legality of this.
> Basically it seems kind of silly to tightly define it as "going to jail", when the practical aspects of willfully violating an NDA can ruin your life (which may or may not be worse than going to jail depending on circumstances)

It was specifically referred to as your "liberty" which is incorrect. I never argued that violating an NDA could or could not result in something worse than jail time.
This is completely appalling and a blatant ripoff of Handy. I hope they don't get away with this.
Yeah, I assume that people are already mostly making economically sensible choices with used cars, so incentives there would mostly just shift prices.
I've never understood this, every Go user swears on gofmt for some reason that I just dont get. Can you elaborate how gofmt changed your life? Its a really simple tool and lots of languages have those...
You can even do that in C (non-standard, of course) using clang with the Blocks extension
What is your definition of "first-class values" that C++ functions don't fit?
They're probably not porting over accounts by default, but rather waiting for users to express interest by clicking the link in the marketing email.

From the original post:

> Worst still, as I navigated around the site I realized the email link I clicked logged me into “My Account”. This screen had lots of my personal information, home address, email, even my credit card number.
That's a bit brazen to make those claims on the site. They can get into trouble for that and also ruin their own reputation. So I am thinking the site is a little joke? When you click on help and go to FAQs, it labels questions as "HOT".

I think it is a joke.
This is a typical instance of solving language issues with excessive tooling. I find it uneasy that we will be reproducing all the baggage Java required us in a different language. And even Java didn't have mandatory imports.
Schneier really isn't using "doxing" the way you and I would. He's using it to refer to what happened to Mat Honan[0], when someone managed to social engineer Amazon customer service and Apple tech support to take over Honan's accounts. Honan didn't do anything wrong, or release too much data to the public. He simply made the "mistake" of owning @mat on Twitter. Someone wanted the username, so they tricked Apple tech support (using data they got by calling Amazon) into thinking they were Honan, hacked into his account and took what they wanted.

The point of the article is that in a case like this, Apple and Amazon are both at fault, and should be held legally responsible.

[0] http://www.wired.com/2012/08/apple-amazon-mat-honan-hacking/
If you have to add "practically speaking" to a statement then I would argue your statement is poor in the first place. There is a difference in signing away a "liberty" and signing a contract. A really, really huge difference. Let's just speak clearly.
Well, there's nothing keeping a well-defined tor scheme from including the protocol information in it, is there? For example, I could imagine specifying a tor URI in my git config: onion:ssh:pcl@aoeusnth or onion:http:aoeusnth
discussed on the frontpage: https://news.ycombinator.com/item?id=10466888
https://libraries.io/ - "Libraries.io monitors 1,057,223 open source libraries across 29 different package managers. You can discover new libraries to use in your software projects as well as be notified of new releases to keep your applications secure and up to date. "
Oh that's not shady at all. Assuming all this is legal (I doubt it, but hypothetically) how is this a good marketing tactic? Having all this info already stored comes off as way more creepy than convenient as evidenced by the author of the article. And yeah, I can't see this being legal in a thousand years.
How would that work since there is no sound in space? As I understand, sound vibrates against molecules drifting around and since those molecules don't exist in space, it wouldn't work.
Bad for somebody, but still fun! This is the sort of thing I could imagine a dictator of a 'stan or a drug lord doing...
Paging Dr. Malcom...
> It says it right in the article

No, the article says the JLENS program is on a three-year test run to see if it can help detect cruise missiles or enemy aircraft from 10,000 feet above ground.

That three years is up this year (started program in 2012)... so perhaps they will be decommissioned, or re-purposed.

My statement was more along the conspiracy theory line of domestic surveillance tech being tested.
> The big difference with stuff like GC and re-writing stuff in go slowing the compiler time is that they are not inherent to the language.

Actually, I think GC is inherent to the language, and that's why I listed it as one of the trade-offs that Go made (not the Go implementation made). Almost every language construct depends on GC, e.g. append(), make(), and more. Even the following innocent-looking code:

func f() *int {
a := 1
return &a
}

is GC-dependent, because it would result in a dangling pointer in non-GC languages. But the code is perfectly fine in Go because GC is inherent to the language. It is not possible to make GC optional in Go, so the performance penalty will stay there forever, only alleviated as the implementation matures (or sometimes regressed, as Go 1.5 shows), unless you use only unsafe.Pointer all the time.
We tested out Storwize years ago before IBM bought them.. What a piece of garbage, in my experience. "Oh, it won't slow down access to the NetApp at all!"... riiiight.

Had them sitting in front of the filers for two days before we yanked them out. Then it took them another TWO YEARS to send us boxes to return the systems despite repeated requests.
French city gets public 'short story dispensers' to help people kill time
Did you notice they literally copied their competitors site?

Testimonials are the least of their worries.
>It's simply providing a pathway to level the playing field.

This doesn't level the playing field. It specifically encourages employers to treat their female employees differently than male employees.

As Bryana mentioned in her blog, it's pretty much impossible for a woman to not be singled out in STEM, simply because she is a woman. Men almost never have to worry about their gender being brought up, while women generally either have to deal with being looked down or being put on a pedestal.

You can thank "people deliberately righting wrongs such as by giving extra encouragement to female developers" for this additional layer of sexism in STEM...
Strong winds broke the tether. When it is at altitude, there is ~1 tether.
21 year old Developer creates app to combat night terrors in Veterans
> And it likely played well with Western executives, who preferred to hear that their product was being mass produced in factories rather than subcontracted to rural artists.

Absolutely fascinating! That's quite an interesting discussion point.
Can we kill the "teachers aren't paid enough" heads in here? They are the weakest of all performing of all majors (http://blogs.edweek.org/edweek/rick_hess_straight_up/2011/09...). Get a business degree and you can end up in Starbucks. Get a Ed degree, work less in college, and end up with an above average starting salary when you calculate in time off.

Or go STEM, work your butt off, and get paid well. These are grown up choices.
We just had a terrible rainstorm and I just got water splashed at me by a car lol.

Lets hope the luck turns around.