skysight-inc/HackerNews huggingface dataset:
Recursion Pharmaceuticals | SLC, Utah | Onsite, full-time

Senior Data Scientist | Senior Software Engineer

We have 20 TB of high-resolution images of human cells, some diseased, some healthy, which we have to statistically distinguish as a first step to finding cures for rare genetic diseases. Our small team of biology and math Ph.D.’s has the potential to save lives and be at the forefront of the revolution in image-based biological analysis.

What we do

There are more than 5,000 untreated rare genetic diseases, which together affect nearly ten million people in the US alone. Each of these diseases affects too few people for traditional pharmaceutical companies to approach them, so we're building a way to seek treatments for hundreds of these diseases in parallel. We aim to find treatments for 100 of them in the next 10 years.

What you’ll do

Our biologists run cellular experiments, and our data scientists build models from cell data.

Engineering: The chief job of the engineering team is to extract data from cells and hand it to the data scientists quickly and reliably. As the engineering team’s second member, you’ll advance the automated cloud infrastructure, currently mainly in Go and running on EC2 and S3, to process and manage >1TB of new biological images per week, among other critical items.

Data science: As the second member of our data science team, you’ll collaborate with our biologists to guide our experimental design, improve the models that drive our analysis, and use our data answer questions that guide our scientific and technical strategy. We currently work mainly with the python scientific stack, including pandas and IPython, and making some use of such libraries as sklearn, while also building our own models for machine learning and statistical inference.

See the posts linked below for more details.

Logistics

We're based in Research Park at the edge of the mountains overlooking Salt Lake City, Utah. Gorgeous hiking/running/biking is literally out our back door, and it's half an hour to 5 top ski resorts. We offer competitive pay, health insurance, relocation assistance (working at the office is part of the deal), equity, an awesome team to work with, and the chance to impact the world in a massively positive way.

Apply

Data science post: http://www.recursionpharma.com/senior-python-data-scientist.... Data science applications: datasci@recursionpharma.com

Software engineering post: http://www.recursionpharma.com/senior-software-engineer.html: Applications to engineering @recursionpharma.com.

See who we are: http://www.recursionpharma.com/team
From the EPA news release [0], your 2015 Q5 TDI seems to be safe: "on September 25th EPA initiated testing of all 2015 and 2016 light duty diesel models available in the U.S using updated testing procedures specifically designed to detect potential defeat devices".

It's also possible that EPA just hasn't finished testing all of the vehicles yet and your particular car may get added to the list. Sorry about that. I actually test drove the Touraeg TDI that shares the same engine and almost bought one a couple of years ago...

0 - http://yosemite.epa.gov/opa/admpress.nsf/0/4A45A5661216E66C8...
I've been learning more about lease-option contracts. My goal is to understand how to determine interest rates for lessee's who lack a formal credit history. But have a year or more of lease payment history.

Also, studying the growth of suburbs in Santa Clara and Alameda Counties during the post war period. It really helps in understanding some recent urban planning policies.
Plus Google has a shit ton of redundancy. I remember watching a video about their site reliability team. Their job is to test worst case scenarios and they can/will cut an entire datacenter out of a service's (gmail, drive, etc) pool to see what happens.
It's interesting to think about this sort of thing in regards to corporate influence on government processes.
George Boole: A 200-Year View
Youth e-cig bans lead to increased traditional cigarette smoking [pdf]
That's why I'd like to get it tested. I think they may have gone with the 2016 since that's what is currently on the lot, but I am very skeptical it is new to the 2016 model year when the required standards and engine did not change.
For simplicity, the summary of the important aspect is "synthetic control analyses consider how state bans on e-cigarette sales to minors influence teen smoking rates. These bans yield a statistically significant 1.0 percentage point increase in recent smoking in this age group, relative to states without such bans."

This same author released a similarly titled paper 2 weeks ago, but that is behind a paywall so I have linked to this one instead from 6 months ago. This paper contains the same important implications that the recent one does, though because I do not have access to the new paper I am unsure of what exactly is different.

New paper here for the curious:

http://www.sciencedirect.com/science/article/pii/S0167629615...
And armchair liberals sit back and whine in their elitist towers. "You're doing it wrong!!!!!"
That's a little misleading: the video has a "do you want to see the crashes" link:

https://www.youtube.com/watch?v=QgrvrD_GOvg&feature=iv&src_v...
What sucks is that in the end this will be swept under the rug and no one will be held accountable for lining their own pockets.
I also read about Bosch's involvement but this story was based on a report by the Bild am Sonntag newspaper which is not trustworthy. [1] is an English language source that relays this report. The gist of the story was that Bosch supplied the software for R&D purposes and Volkswagen engineers decided to put it into production cars too.

However, this was later rejected by Bosch who claim that writing additional code is required by the car manufacturer to get the emissions test detection feature [2].

[1] http://blog.caranddriver.com/report-bosch-warned-vw-about-di...
[2] http://www.reuters.com/article/2015/10/07/volkswagen-emissio...
That's not listed as an advantage - just highlighting the technology.
Why are you not waiting for secure software instead of being specific like that (SQL injections)? Do you think that it will never happen?
Private Internet Access | West Hollywood, CA or REMOTE | Full-Stack Engineers

https://www.privateinternetaccess.com/

We run one of the world's leading VPN services and are looking to grow both the Private Internet Access team as well as find engineers to help us on new projects. We are especially interested in people who care about privacy and freedom. We have a couple of different open positions:

IRC Software Engineer (Ruby)

* Intimate knowledge of IRC protocol (RFC 1459 et al., CTCP, \001ACTION, etc.)
* Experience writing IRC bots and services (at the IRC protocol level)

Web & Email Software Engineer (node.js, Ruby, shell script)

* Intimate knowledge of email protocols (SMTP, IMAP, etc.) and relevant RFCs
* Experience writing MTAs, MUAs, or email filtering tools
* Familiarity with secure coding practices, including running untrusted code
(JavaScript) in a sandbox

Network Software Engineer (C/C++)

* Knowledge of cross-platform networking APIs (iOS, Android, Win, Linux)
* Experience implementing custom protocols over TCP or UDP
* Low-level networking stack and VPN (e.g., OpenVPN, SSL-VPN, etc.)
experience is a huge plus

Mobile Engineer (iOS, Android)

* Comfortable with C/C++ and JNI glue logic on Android
* An eye for good design and knowledge of interface design guidelines
* Prior experience implementing beautiful UIs

We're a remote team (unless you happen to be based in the LA area, in which case you'd want to come work from our beautiful office in West Hollywood), and all of our collaboration happens over Slack and Trello, with the occasional email.

Email jobs@privateinternetaccess.com with your resume and/or links to projects you've worked on, a link to your GitHub (or some other site where we can see your code), and what makes you interested in our company. Don't forget to mention you're from HN!
Sadly I agree. In modern TV it is unthinkable to have a character like Picard who tries to pursue a diplomatic solution instead of the shoot first, might makes right attitude so prevalent in modern newspapers and other fictions.

On a somewhat related note, CBS apparently tries to get a good start for their streaming site, this means that they will try to limit risk. So they will probably go for a darker tone and something like Game of Thrones in space.
I do normally agree with your posts but this seems ... distressingly principled, if you like :)

If we adhere to the idea that "money is speech" (Buckley v Valeo) and resist all attempts at suppressing speech, how do we avoid an eventual slide into plutocracy when upwards of 90% of all elections these days are won by the candidate who spends the most money?
Can we please get a gradual plan for looping in the rest of the mainline linux ecosystem?

The desktop market may be shit, but it's there and google could still go after it if they wanted to. At some point Apple is going to realize that the major market it hasn't dominated yet is... the PC, and it's ripe for attack now that alternative computing footholds are so well established in mobile from the Microsoft days of yore.
Google plans drone delivery service for 2017
You are correct; Quark goes on a few rants about this in DS9. Also since the Ferengi are so terrible with fighting, considering it a waste of resources (excluding the marauders in TNG but those are later implied to be a minority) that we can safely assume they never had any world wars of their own.
> But academics insist that all stocks have value based on their dividends.

That's a strange statement (by the academics, not by you!) since quite a few companies stocks are traded that have to date never issued a single dividend and that may not issue dividends for a quite a while to come. And still somehow the market seems to be able to assign a value to those stocks.

I think that one way of interpreting this is that - just like with start-up valuations - as long as you're growing / adapting / investing dividends are out of the question and the value is mostly based on the story and the dream. Turnover and other numbers are useful but ultimately not as useful as money returned to investors (otherwise, why invest at all?). But once the moment of dividend arrives (and growth / investment) have stopped and the company is now in its middle age that those dividends will be the marker used to re-calibrate the value of the stock. Dividends are a lot easier to use as an input into a formula than dreams and stories which are just repackaged hope.

That's one reason why I find it nearly impossible to put a hard number on the value of a start-up, it's essentially asking for a crystal ball.
Apparently a lot of people who make these sorts of modifications can pass emission tests. They hook up a settings swapper to the ECU, and when they need it to be clean, they put it into factory default mode. It is essentially the same sort of cheating as VW.
IIRC correctly PAE was used anyway on the editions of windows limited to 4G. And legacy drivers are always managed by putting their dma buffers in safe zones. This was purely a limitation for market segmentation.
Comcast bashes Google Fiber and it hilariously backfires
The mortality rate for whites 45 to 54 years old with no more than a high school education increased by 134 deaths per 100,000 people from 1999 to 2014.

This should surprise no one. These are the people who work marginal jobs and they have been the most affected by so much manufacturing moving offshore, the resultant shift to service sector employment, and the downward push on service wages created by massive immigration of unskilled South American workers. (Not to mention the political and social demonization of this cohort.)
The insight into only needing the differentials in the next 10 meters makes a load of sense and clearly worked.

Why is everyone hating on the video? I thought it was light-hearted and fun.
You can do some pretty cool stuff when you're an MVNO. No need for custom dialers (which wouldn't be much fun on iOS anyways).

The system uses inbound calls, calling history and contacts to learn how to handle outbound call. User preferences control the defaults.

Get a call from Fred on the first number, all calls to Fred will use that number. Make a call to Mary with the second number, future calls to Mary will use the second number.

Throw in multiple sets of contacts from your work and personal email accounts and it's going to be pretty smooth.

Full disclosure: the co-founder is a friend. I have no involvement in Mast though.
Solar panel shade won’t cool Earth
It is hinv! I was very fortunate to have worked and had nonstop access to SGI boxes from very early age. Most of learning and work I did was on Indigo2 boxes (green and purple ones (MAXIMUM IMPACT!) :)) and later on on Octanes and some on O2s if Octane was having a vacation. One machine that, to this day, I really adored was also the first SGI I had my hands on - Crimson. We didn't spend much time together because new SGI boxes were on their way towards where I was at, but little time we spent together was magical. I was (VERY) young and impressionable! Other machines I had pretty much learned on and later on worked on (graphics) were either Sun boxes or Amigas. I didn't get serious introduction to PCs and Macs (apart from games) until far later on. SGI is where I started. Time to bring that Octane2 to life. Thanks!
What a country!
Why did Chris (the CTO) leave? Was he fired?
$0.00/forever is also trivial, with so many OSS alternatives out there.
Yeah, they sortof suck, but we're 20T in the hole and 9% of the federal budget goes to debt service. That sucks more!

When do the rabble on the right who instigate these debt showdowns get to be the righteous good guys instead of demons? Do we really need to spiral down to some catastrophe before we wake up and make a change here? It's the banksters accumulating most of the power with this debt here. I suspect the left will do the opposite of what should be done and install more growth-slowing policies and spend even more rapidly than the establishment republicans have.
Lessig's actions in the past several years have been a major disappointment. I admired his work in pushing the copyright case (Eldred v. Ashcroft) all the way to the Supreme Court. Even though he lost, that at least got the issue into the media a little bit, something no one else has managed; that's something that could have been built upon.

But instead of building on that and (for example) working with tech indistries to lobby for more sensible copyright legislation, he decided to go after a far more enormous and difficult task of somehow reforming the entire election system, something which I have to wonder if he even has any particular qualifications or experience to do. Then he decided that the way to accomplish that was to run for President, which is generally taken by the media and most people who follow politics as the sign of a crank. And now that's evaporated, as one would have expected, and we're back where we started. No Presidency, certainly no election law reform, and the same old awful copyright laws getting worse all the time.
...is not a fault of the article, but of your own reading.

That strikes me as uncomfortably close to an ad hominem.
Pick an overly high price, and if you run into resistance, work your way down.

Position yourselves as being "in beta", with a successful customer(even if it's your team). Start at $10k, and do everything you can to get the your customer to be successful.

If people object to the price, respond with the value your product, not discounts.

The more people pay for something, the more they are going to like what they bought, and the more likely they are to use the service.
Apparently what I was taught was wrong. The AK-47 was made after WWII not during it.

HN members usually downvote when something is incorrect, even if it was not my fault but the teacher who taught me that.

I usually make mistakes and get downvoted for them. What I was taught about Windows NT had some inaccuracies in it and got downvoted for that. If you look at my history every once in a while I got downvoted and get used to it. But I get upvoted more than downvoted so it averages out.
You can run linux/gnu concurrently with most android phones today, just not so easily[1] and not as polished and with the caveat that there is no GPU acceleration[2]. There are a few apps that do it but AFAIK Linuxdeploy is the best.

1. meaning rooting and flashing a 3rd party kernel for starters.

2. intel's next atom version for smartphones due 2016 could well solve this-- currently they use powerVR GPUs in smartphone atom chips, which like all current smartphone GPUs lack OSS drivers. (And being x86 sublimetext would actually work too-- where is the ARM bulid!!.. it would make this so useful)
15 Years on (the International Space) Station
A group that I am a member of. Perhaps I'm biased but I don't feel like my life is particularly worsened.

I've had the misfortune of bearing witness to paranoia fueled by both mental illness and drug abuse (and a combination of both). I've also worked with and for unapologetic assholes. There are things about this case and his communications that have me leaning toward the former.
Do you encrypt your email? Do all of your recipients?

Slack is sold as a replacement for email, in many cases - so I fail to see how it's any worse than sending unencrypted emails all over the interwebs.

And this tin-foil hat conspiracy insanity about how you shouldn't use external services like Gmail, or Slack because "Oh noes, they have our data" is just that - insanity.

Sure, if you're paranoid, you're free not to use those services.

But let's be honest, most of aren't working at Lockheed Martin, or the NSA. Our personal lives are inane and boring, and the majority of our work discussions are probably, outside of the context of our work groups, inanely boring as well. Nobody cares (which is fine).

On the list of things to worry about, from meteorite strikes to global warming, I'd put, my chat provider trawling through my personal chats fairly low on the list.
AnyPerk • San Francisco • Full Time • ONSITE

We are the AnyPerk engineering team, and we design and polish the system driving awesome benefits to thousands of companies daily.

• Rails Full Stack Engineers -- Someone who is familiar and experienced with Rails but not afraid of working with JS on the front-end either.

• Rails Apprentices -- Looking for recent bootcamp or university graduates who would like to get 1on1 mentoring from an experienced engineer on our staff with the intention of becoming a full member of the team after 3 months!

Read more about the positions at https://jobs.lever.co/anyperk or shoot recruiting@anyperk.com an email for more information!
The Navy really wants to get rid of pilots as it seems.
That is a good point. You may very well be correct.

I think that from an economic perspective, reduced fuel economy is also beneficial to the environment because the driver is less likely to spend money traveling (keeping the vehicle's engine running, producing pollution) when the cost is higher.

However if the vehicles in question were part of a fleet whose behavior would not change much based on fuel costs, there would seem to be nothing but downside to diminished fuel economy.

What's interesting to me about this is that it seems that a few other manufacturers were able to engineer diesel engines with power, fuel economy, and emissions characteristics that met the guidelines without cheating. It would seem that this is quite a feat, if VW had to resort to gaming the system.

On a tangential note, I also find it interesting that we accept certain tradeoffs about noise pollution vs air pollution, since if we simply removed mufflers from cars, fuel economy would increase.
I could be wrong, but I think what you are asking for is covered in Ember's router.
It's just an announcement - it's way too early to tell how the series is going to turn out. That being said, I would be surprised if the reboot becomes a cultural landmark like TOS. I just hope it's at least good, compelling television. At best I hope it captures the genius of good Star Trek: exploring new ideas, concepts, and perspectives, with clever & humane writing, capable acting, and good special effects.

I hope it's not too heavy on the action/drama, like _The Walking Dead_ or _Game of Thrones_. These are both excellent series that are highly entertaining to watch. But they make me _feel_ first and _think_ second.

Good Star Trek episodes are like puzzles. You're thinking "what the heck is going on?", "what strange phenomena is this?", etc. The best ones draw you in and then delight you with the reveal. They almost have a Twilight Zone quality to them.
MailTime | Full Time | San Francisco | ONSITE | VISA sponsorship available

We're currently hiring an Android Engineer and a QA Engineer, and are always looking for talented developers.
MailTime is building an open messaging service using email technology. Our founding team has prior mobile messaging success with Talkbox, and are now a seed funded team of 12 based in SF's SOMA district.

I could talk about the free team lunches and flexible hours and other perks, but as Peter Thiel put it, aren't the only 2 good reasons to join a startup 'the team and the mission'? Join our passionate team in building a truly open messenger!

Learn more at https://angel.co/mailtime/jobs or email jobs@mailtime.com
Show HN: clarity keyboard – an iPhone keyboard to answer almost any question
Please, don't use these tools. Yes, they may fix the immediate problem, but you're still rewarding Microsoft with money and/or market share. You're sending them the message that you are loyal even when they abuse their power in obvious ways. By continuing to use their platform, you're conditioning[1] Microsoft to continue with stronger spyware in the future.

Unless they see an actual reduction in revenue and fewer people using their platform, this problem is only going to get worse.

[1] operant conditioning (Skinner )
Nest | Full Time | Palo Alto, Kirkland, Boulder | ONSITE

Nest is taking your everyday devices and making them smarter starting with Thermostat, Smoke Alarm, and Security Camera.

We're hiring several important Product Management & Engineering roles: iOS/Android Engineers, Hardware Engineers, Services & API engineers, DevOps and QA.

We're a relatively small team of passionate individuals who believe in innovation and strive to improve lives of our users. You will have an opportunity take on a big role, make a huge impact, and set Nest up for next growth stage.

Check out our jobs page at https://nest.com/careers/
Yeah, once you're at the point where someone can't distinguish your behavior from that of a troll, well...

At any rate, they should have done something to prevent anyone from registering with your username. Even if it's just a one off redirect on their reverse proxy/gateway.
Just want to say: whatever is going on with the margins here is making this blog very hard to read on mobile. (iPhone 5)
That's a rather intriguing causal chain of responsibility, though. You didn't say that Nader was a potential chain reaction for the election of Bush leading up to Iraq. No. You quite clearly said he was the reason for Iraq, and that is nothing but frothing lunacy. What kind of perverse ethics could lead to anyone but the actor who affirmed invasion (Bush) bearing responsibility for it? Or, to paraphrase from a scene in Kieslowski's film Przypadek, is someone who bumps into a person causing them to miss a train, leading them to encounter an old acquaintance, reuniting, becoming a doctor and taking the place of a colleague to deliver a lecture in another country, only to die in a plane crash - is the one who bumped him responsible for the doctor then dying in the crash? Preposterous.