skysight-inc/HackerNews huggingface dataset:
A quick answer to your question #1/2: microRNA (miRNA) is the substrate of a very complex piece of cell machinery that uses the miRNA sequence to find complementary messenger RNA (mRNA). When miRNA binds to its respective mRNA, the machinery (whose details I will not go into) degrades the mRNA, preventing its translation into protein. So while the DNA remains unaltered by the miRNA, protein expression is regulated on the level of mRNA degradation. MiRNA and short-hairpin RNA are tremendously useful in the laboratory setting to knock down the expression of genes without having to do gene modifications. This paper shows that miRNA can be passed from father to child through the sperm, and this miRNA can affect the way certain genes are expressed.

As for your question #3, I couldn't find any information in the paper regarding how long the miRNA persisted in the offspring. The miRNAs seem to have a long-term effect on genes in the paraventricular nucleus of the hypothalamus, but whether this is due to effects of miRNA solely in the development of the zygote, or whether the miRNA in the adult is also important, is unclear. It seems likely that changes due to the miRNA in fetal development alone could be sufficient in dramatically changing stress responsitivity, but this remains to be proven.

In another famous study, maternal nurture plays a very important role in the epigenetic development of baby mice [1]. So it could very well be that a favorable and nurturing environment may cause epigenetic changes in the offspring that might counteract the actions of the miRNA described here. Again, this is something that the paper does not show and therefore we can only speculate at this point.

Hope this helps!

[1] http://www.nature.com/neuro/journal/v7/n8/full/nn1276.html
I've built the same thing using NodeJS a couple of weeks ago, with phantomjs support (javascript execution), mandrill (emailing) & and some other nice options: https://github.com/mgcrea/node-web-watcher
I don't think it's just technical queries. I have to look up a bunch of tech and nsfw stuff, and when google tries to think for me, it ends up going to shit. I usually end up just "searching" "like" "this". Even then, it tends to ignore words in quotes |:(
I've noticed it's less about the suit and more about the tie. If I wear a suit without a tie to work, I get some compliments, but when I wear a tie, with or without a suit, the CEO will start joking that I'm going to a job interview later on.

A suit is just clothes. A tie is a statement.
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Stop buying into the "lack of talent in tech" myth and lower the H1B cap to force tech companies to hire workers (old, black, women, whatever) currently in the national workforce instead of importing cheap labor from overseas.
At some point, you do assign a probability of systemic failure threshold, as nothing is perfect.

The idea behind orthogonal backups, however, is that since they are independent, very high reliability can be achieved with low reliable components. For example, if you've got a main with 90% reliability, and a backup with 90% reliability, the combined reliability is 99%. This can be a lot easier and less expensive to achieve than making one component 99%.

The backup generators could have a cheap extra seawall built around them, or could have simply raised them up on a 10 foot platform, or built them with snorkels like a jeep designed to cross streams.

Building a heftier main seawall would have been an order of magnitude or two more expensive.
Tesla's Autopilot approved for international use
Whenever I can spare the time, I try to make mobile apps and computer games. I think it can add value to the world.

But compared to calling the shots in the dark on a imminent nuclear holocaust? Geez louise. If this story is true, this guy did far, far more for the world than any app or gizmo I could hope to see developed by me or others. It seems our destructive capabilities (which are practically infinite) in some sense far outweigh our creative capabilities. It's too bad nobody throws a few million dollars at this guy or his family like money is thrown at promising startups. Even if having saved the world is a sunk benefit (a la sunk cost), it would be well-deserved.

Equally interesting, his Soviet counterpart:
https://en.wikipedia.org/wiki/Vasili_Arkhipov
I still don't see exactly how they were able to "own" the trademark. They didn't create the mod or the game, they just hired the 3rd developer who was mostly doing balance improvements during his tenure. There was a whole community around DotA that suddenly had to migrate to "official" channels.
Intriguing. Never thought of that.
Great, I remember seeing full home automation system implemented with a C128 - its not the hardware holding us back! :) Also, impressive as this is, I think the author should team up with some of the peeps from the demo scene, since there's no reason why this OS shouldn't have full fluid-animation screen changes - https://www.youtube.com/watch?v=DzQVECn3tY8
You would want to work with someone that says all of college sports is "Rapey"? I'm sorry, that's not professional or mature.
If you count colorectal, prostate and breast cancer as lifestyle diseases and that (a meat) diet is related to those - then the numbers are very high.
Upon updating Chrome this morning I got this page: http://i.imgur.com/iCU0100.png

The button didn't work and I'm leaning towards this being a bug. If this is intended, I'll be uninstalling. I do not approve of this behavior in apps.
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The irony of an article from 1974 with a link bait title in a Medical Journal! If one of the other names was in the title I would never have scanned this article.
Meat has been linked with colorectal, prostate and breast cancer not to mention heart disease. So if you take more of an holistic view.. it is quite damaging to yourself.
And replaced by what? A more divided Europe? I know UE is not the United Federation of Planets, but at least it is a step towards it.
https://news.ycombinator.com/item?id=10447010
This is a valid point, I think the effect will usually be small.

1. If a company is paying above-market wages, then by definition there are more people who want to work there than there are available spots, so the second company will get some of the overflow.

2. The market for a particular kind of labor (e.g. phone techs) is usually much larger than whatever market for outputs these two companies are involved in (e.g., credit-card processing), so one company paying above-market wages is unlikely to change the market wage level very much.

This could definitely break down for some very specialized jobs.
You cannot engineer out human nature.

You can do a lot to minimize the effects of human nature or even utilize it. You just need to build systems for humans not some abstract ideal. Case in point, the giant Menu inside a fast food restaurant has a lot of counter intuitive properties designed to alter people’s behavior. It's not pretty, but it works. Note, we are talking about the masses of humanity not just those you select or train etc.

Now, doing the same for complex systems is hard. But, clearly there are ways to improve.
Eh, I think the idea is that you get to a point where you can have professional/working relationships with others even if you don't really like them. I know I have. It would be nice if all of my coworkers and collaborators were my best buds but in reality, you run into all kinds and sometimes you just don't like people you work with. And that's fine. It's a mark of professionalism when you can still take care of a job even if you think someone's politics or personality are incompatible with yours.
Don't lose energy chasing dropbeats. Instead, spend time thinking how you can make your product less prone to people outsmarting you.

Use dropbeats to test new features by forcing them to test them first. If they work, you will have more assurance when deploying to other paying customers. If they don't work, the exchange of emails will help you know each other better, that is employ your dropbeats as free testers.
You haven't established that cancer in meat eaters is largely caused by eating meat, whereas it is quite clear that overall cancer rate drastically increases in smokers.

In fact, while vegetarian diets do reduce the risk of cancer, the difference is by comparison modest - the overall risk of cancer in vegetarians is ~10% lower.
Personal data is almost certainly in the top two. Stating that, however, would raise privacy concerns from users.
Some of the examples given seem either unrelated or rather disturbing if they are related. Specifically, the reference to Tim Hunt and Justine Sacco seem to be there to promote a "Free expression and liberty are under attack!" narrative, which is a seemingly true enough point, but hopefully not relevant to the topic of counter-terrorism legislation. Should Britain have located and arrested everyone who contributed to those stories blowing up? If not, then why are these incidents being brought up in this governmental context?

Mob justice is antithetical to free expression, but is messy and complicated, and governmental action is too blunt a tool to fight it with.
That's irrelevant. The point is that whether your record is 1 byte or 1000 bytes, you still write only 1 node. In an LSM, the write amplification is a large multiple of your record size.
Can you be added to a watchlist for playing a video game?
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> (vest without jacket is just as bad, except it's "I'm a waiter")

Pretty much only if it is a black vest with black pants and black tie and black or white shirt.
This is actually pretty useful for HAM and any other radio activity. Thanks!
Walnuts are likely to kill you
Boy, 15, arrested in Northern Ireland over TalkTalk hack
Zan – A drop in replacement for React.Proptypes where everything `isRequired`
IMO the more important example that Gankro failed to mention is division, where your language has to do something when the denominator is zero.
What was wrong with sovereign nations?

A step towards what? This is the big scam of the 21st century. People think that big blobs are stronger than smaller, more focused and cohesive entities. Smaller countries all over the world are doing just fine.
GRPC framework reaches API stability milestone
This is a perfect example of confusing correlation with causation.
Ask yourself why the generic UI elements in Polymer, like Menu, Dialog Boxes, etc.., isn't part of HTML itself?

If you want to see balkanized UI frameworks, there it is.
"Finding a warm body to drag a tepid rag around your countertop is easy"

Back in the day I had a cleaning service that I trusted and used regularly put a wet rag on top of a CSU/DSU [1]. Not something that I ever thought could happen. Ironically the spare CSU/DSU was sitting right next to that. (Cold and ready to be put in service if the main one failed.) There were of course vents on the top. That's where the rag went. And I was near the equipment at the time (I would never let a cleaning service in where there was sensitive equipment without being onsite).

[1] https://en.wikipedia.org/wiki/CSU/DSU
Could you please make this legal in the US by honoring robots.txt and scanning any links to the ToS for words forbidding "automated access", "crawling", "spidering", "polling", etc.?
The next nuclear accident that will occur in the world is 100% preventable, and without any hindsight bias I will tell you exactly how... after it occurs.

/s

(seriously, if you want me to take a claim seriously that accidents are preventable, talk about what we are doing wrong today, not in the past.)
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It seems more like the anthropic principal than survivorship bias -- since we're here talking about it, we must live in a universe where the fail-safes work.
Wow! That's low...

"we found that if everyone in California got rid of their lawn, it would
save 5-7% of total water usage in the state."
> Most of your arguments here are based on the fact that halo is only released on console. It's obvious then that it would have these console shooter features. If it were released on PC it obviously would not have aim assist.

Its a much much bigger deal than you think. Not only is player camera movement effected but the entire flow of the game - all the weapons, the chokepoints, areas to balance all become REALLY different when you change the targeted control scheme. Go into games like Titanfall and CoD on a console and then try them on PC - PC players are MUCH more aggressive and use the map and weapons quite differently because their control scheme allows it, while on console people are much more likely to be slower and methodical in their play.
GPLv2 incompatibility does seem like a possible issue. Moving to Apache would make it impossible to ever embed LLVM in the Linux kernel, for example. That might seem unnecessary now, but perhaps someday there will be a use for a JIT in the kernel, that we can't foresee.

The same problem might exist with other patent clauses, though - is the Go one compatible with GPLv2?
If this kind of post can be dismissed as cliche, its an indication of a problem in the industry and not with the writer.

The commenters that preceded me would do well to remember her article is a venting on Tumblr, and not the conversation she had with her co-workers or manager. Denigrating her tumblr post for being an inappropriate work attitude misses the point.
Great to see such a progress. I hope within a decade or two HTML will finally allow us to create convenient reusable building blocks.
the NBA league pass service is also limited because you can't watch nationally televised games ( any games on ESPN, NBAtv, TNT, NBC, ABC, etc etc )
It would be good to have a monument somewhere with the names of as many people as possible who acted sanely during those dangerous days - the least we can do is remember them and take it as a lesson.
There is an excellent standup comedy routine on being the youngest child and surviving until teens. I'll link to it when I could recollect who did it.
You're looking for "<style scoped>", which is in Firefox, used to be in Chrome, but was eventually removed in favor of Shadow DOM.

http://html5doctor.com/the-scoped-attribute/

http://caniuse.com/#feat=style-scoped

https://groups.google.com/a/chromium.org/forum/#!searchin/bl...

I think the main reason webcomponents won out over scoped styles is because usually once you need to scope your styles, you find you also need to scope your querySelector calls, and your DOM traversals, and your IDs....and pretty soon you have shadow DOM. It's unlikely that you need style namespacing if you're just a single dev working on a static page, and it's unlikely that you won't need JS & DOM scoping if your product grows beyond that.
Rover.com is great for pet sitting, and care.com is great for finding a home care provider.

However both of these sites will have the same problem as Homejoy. I used rover.com to book pet sitting just for the insurance, but after a few positive experiences, I am now booking directly with the pet sitter. Same thing happens on care.com almost all the time.

These sites are more valuable as a craigslist or angie's list competitor: Use them once or twice per year, then don't visit the site again after you've found your provider.

They should focus on making money from listing fees, insurance premiums, and being the strongest market for their respective industries at all times, so that when I go back to the site in 6 months time, I can trust that it will be just as good an experience as it was last time.
> much to my disappointment as I'm just learning rust

Then prepare to be disappointed by Haskell as well, where the equivalent function is called `fromJust`. :P

Both languages discourage the use of these constructs, but they exist for good reasons.
Maybe the grim lesson is that a crass bigot in a suit gets better treatment than a decent person in casual.
The real science is the stuff the powers that be will take care of for you. Just say "yes" when the doctor asks to vaccinate your kid or rush her to the NICU.
The InfluxDB experience shows that the answer is more complicated than that - they're storing time-series data, which they thought an LSM would be good for. But in reality, they're storing multiple series simultaneously. That turns the simple sequential workload into a very random one. Each write is a sequence of K/V pairs:

A:1, B:1, C:1, D:1, E:1
A:2, B:2, C:2, D:2, E:2

This turns into the worst-case key ordering for LevelDB because every write overlaps with the previous keys.

Worst-case turns out to be ridiculously bad.

https://news.ycombinator.com/item?id=10437621
Oh yeah, I remember seeing that with coffee-script without the parentheses.
Someone demonstrated a while back that the perfect market hypothesis is equivalent to P=NP. In other words, the "rational actor" so beloved of classical economics is, at best, not possible with current technology.
Indeed, something like the pgp plugin for Apple Mail would be nice.
He's comparing apples to orange tic tacs. Germany provides 140€ per month in cash to asylum seekers plus accommodation (usually a shared dorm room). He's in "a poorer European country" and apparently earns less. He's ignoring costs of living. 140€ is a pittance in Germany. It is much less than pensioners or unemployed get. I spend 3x as much on food.
If you like a discrete control flow, then Polymer is a valid approach. TBH, if your application isn't beyond moderately complex, it doesn't matter too much which framework you choose as long as you have relatively clean separation of logic and control flows.

React (with a flux-like control flow library, such as Redux) has a higher cognitive load to start. Where it shines is as additional features are added, there is very little additional complexity. Where with Polymer (or Angular) your application as will see a curve of additional complexity as features are added.

I started a pretty basic setup for React + Webpack with hot reloading[1]. I'm going to add in Redux next, then Router... At which point I'm planning on adding in material-ui[2]. From there, I'll try to keep it updated or forked to use as a base application.

I started it off by following te SurviveJS book[3], but my direction is a bit different. I'd also recommend reading the full stack redux tutorial[4].

[1] https://github.com/tracker1/r3k-example

[2] http://material-ui.com/#/

[3] http://survivejs.com/

[4] http://survivejs.com/
HTML & CSS are like Siamese twins, you can't separate the one from the other and there will always be coupling between them no matter what and the solution you suggested is not optimal in my opinion as I said earlier that what you'd manage to achieve with this is just to shift the burden from CSS to HTML and to turn the organizational/hierarchical problem in CSS to a greater and unpleasant naming one in HTML that I personally try to avoid as much as possible
You do realize where money comes from right? That the refugees get any thing when actual tax, social security, disability was paid into by citizens for citizens and even if it was as available as you think it should be, the citizens are having their money funneled and real estate taken from them in ways that are unsettling and downright disgraceful.
React Autofill – Fixes Safari Autofill in React
That essay makes some good points. In my previous comment I was thinking mainly of sentences like "Mistakes were made."
How does this tool handle XFA forms?

Or I should ask how does any tool besides Adobe LiveCycle designer handles XFA. I've been using Apache Tika with Apache Solr to index PDF documents -- it worked quite well up until I tried to index XFA-based documents and got nothing, well I got metdatada, but not the content.

[pdftk](https://www.pdflabs.com/docs/pdftk-man-page/#dest-drop-xfa) seems to have an option called drop_xfa, which does just that.
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"Mainstream economics" moved away from convergence in the 1950s to the Solow-Swan exogenous growth models and more recently the controversial endogenous growth models such as the AK and the R&D models. They allow for differences in savings rates and human capital respectively that determine whether or not different economies will reach a steady state or converge with one another. But this is all academic fluff: I doubt anyone at the Fed is plugging data into any of these simple models that professors use to illustrate high level empirical trends ex post facto.

Ultimately, your comment is much more concise and insightful than the post itself. You get to the heart of the matter: central planning vs. free markets. No organization can know enough about every variable that affects an economy to do a perfect job of governing it. On the other hand, without central planning there is little incentive to build infrastructure, protect borders, provide affordable education and healthcare, and create a place where people (excepting Ayn Rand) generally want to live.

Could we have a better system? Probably. Almost everything in the world can be "improved" in one way or another depending on your viewpoint and agenda. But I think its a bit dramatic to hold the viewpoint that "the economists" (whoever they are) are playing a joke on us all the time. They're fallible humans playing their part in a fallible system just like you and me.

It would have been great to see a careful consideration of the other side's viewpoint and a proposal for a better system rather than a short, click baity rant.
Thank you for mentioning that, I should have pointed it out in my initial comment.
I merely wanted to let you know that your assumption that their example was hypothetical was wrong, since you filled it out with some fictitious details instead of the truth. Which you're still doing, in claiming that anybody shot a police officer - no officer was injured in the incident. This would make your suggestion less correct, rather than more correct, since it is false.
I volunteer in a refugee center. Right now about 70% of the people arriving are from Syria. Most others are from Iraq and Afghanistan. If you look at statistics, remember that they often lag behind and currently show a large percentage of refugees from Albania, although that wave happened early in the year and has largely passed.
There are several competing proposals for asset imports [1] any of which are viable. HTML Imports may persist, be supplanted by ES6 imports, or may otherwise survive in a different but similar form. Hell, I wouldn't be surprised if one day someone makes a web component to implement the current HTML Import spec using whatever the browser happens to support.

[1] https://hacks.mozilla.org/2015/06/the-state-of-web-component... (see: HTML Imports)
One of the biggest costs of maintaining a lawn in Southern California is the cost of paying the weekly "mow, blow, and go" gardening service. This cost is actually more than that of the water.

This gardener service cost savings should really be accounted for in estimates of the time to recoup costs when a plastic lawn replaces a real one.
How'd you come to that conclusion?
Good, the video shows Feynman talking about fire and not Feynman burning. I was a bit worried there.
The costumers do get VC-subsidized cleaning for a while though.

(Not saying it great, but it is good for the costumer is the short run.)
Well hopefully the coverage of full-text link metadata in Crossref will increase over time. Until then, best of luck to ContentMine!

Improving metadata coverage is a different issue than changing business model. Objectively, one's easier to implement than the other.

It is indeed tricky getting ~5,000 publishers to provide optimal metadata, but it's a good thing to have an industry-standard platform to do it in.

(I work at Crossref)