skysight-inc/HackerNews huggingface dataset:
From an economic and policy perspective, unfortunately, Turing is doing everything right. Makena is probably not a great comparison as its used for prevent early birth, which is something of an edge case for certain pregnant women, versus Daraprim, which is a more common drug. It is the only FDA approved drug for Toxoplasmosis. According to wikipedia: Up to half of the world's population is infected with toxoplasmosis.[8] In the United States about 23% are affected[9] and in some areas of the world this is up to 95%

What no one seems to be discussing here, is why there is such a long approval process from the FDA for generics? Ideally, someone should be able to ramp up production of this quickly, but apparently it takes years just to get the FDA to test your generic, even if its detected in the lab as being 100% chemically identical to the now expired patented drug. Turing is using this lag time to its benefit, but why aren't we yelling at the FDA to move faster on this kind of thing? I guess this might be moot because Turing can simply drop prices to scare off the investors of this hypothetical generic competitor. Say its x amount to launch this and they need to sell at $25 a pill for 10 years to break even. Turing now drops its price to $24 a pill. They're going to have a lot more flexibility here than someone entering the market from scratch and as long as they're selling above the old generic rate, they will continue to make serious money.

Also, from perhaps a less practical POV, considering what the government spends on medicare (3% of our GDP), perhaps it should be building its own generic drug producing plants. Private industry has 20 long years to make profit on patented drugs, but after that it should go into a federal program. This avoid these situations entirely, cut costs, etc. Or regulate prices on generics, or heaven forbid, finally bite the bullet and migrate into a Euro-style socialized medicine/single payer system and be able to bargain with big pharma as one 800lbs gorilla as opposed to hundreds of 6lbs capuchins.

Expecting people seeking profit to "act nice" is asinine. We can insult Shkreli all day but it doesn't change the status quo. Even if he's an outlier, how long is your average white collar criminal case resolution, assuming he's even doing something illegal? 2, 3, 4, or even 5 years? That's a long time for a drug to be off market or be unaffordable to people who need it.

Right now a lot of people are looking at this business plan with envy. In fact, this kind of generic trickery is status quo - see the "reformulations" of generics and then stopping production of that generic. The system is broken if it allows this kind of thing. What we need is a system that's not broken and that can't be gamed this easily. The current regulation model guarantees companies like Turing doing exactly this.

Sadly, online discussions often degenerate into witch-hunts with the assumption that if we stop this one guy, then everything will be fine. I guess its much less emotionally satisfying to discuss systemic political or regulatory issues.
Opera 15+ operates identically to Chrome because it is just a fork with minimal amounts of changes.
OP should apply for the DV lottery. It's a long shot but it could happen.
There's a lot more to CAS than simply how many bullets your gun has. In any case, it's often not the preferred weapon. Bullets are indiscriminate. Small, precision warheads are becoming more in favor because the safety margin is better.

We've been seeing quite a bit in Afghanistan now where CAS is actually being performed by a B-1 carrying a SNIPER pod, sitting up at medium altitude with a large load of small precision bombs.

But that shows you the type of environment Afghanistan is, where the Air Force can deploy high value assets like a B-1 to perform CAS, because their anti-air threat is non-existent. The Air Force is not developing the F-35 to fight insurgents, they're deploying it to fight a well equipped, conventional force that will have multiple layers of sophisticated weapons. They'll do everything they can to soften these up before the strike aircraft go in. But there /will/ be some that remain, and its in this environment, that the F-35 needs to survive.

In the low-threat environment against insurgents, you can do that job just as well as the A-10 with the A-29 as the article states, for ever cheaper.

This is the conclusion that the Air Force has come to, and that's why they're retiring the A-10.
You're quite right, I apologise.

I was rather dumbfounded when I wrote it and I should have taken the time to calm down and proof before submitting.
Not sure what you mean by that, but these organizations to my mind are really helping the world. Each member of them.
Show HN: Primary Guide – A quick summary of political betting markets
I thought vegabook was referring more to the extent of stockmarket reactions than of the actual fine; I was just pointing out that the market routinely overreacts when egregious misbehaviour is in play.

I can see your point about a possibly outrageous fine out of simple protectionism, but the link to GOOG is total tinfoilery IMHO. The US car market has always been protectionist and well-connected, they don't care about "the country", they just protect their profits.
The A-10 rounds are a tad bit more effective against insurgents hiding than the rounds shot by an F-35.
> it's just a one-time cost to replace all the meters

Much easier said than done.

> At that point all you actually need is a standard IP-based protocol to announce real-time rates. The power company doesn't even need to communicate bidirectionally with individual devices whatsoever -- all they need to do is broadcast the current rate and let the devices make choices

Several problems there (before I get into 'kids these days' mode):

- Meter connected 24/7 just to get prices is not feasible (also remember you need per meter pricing for the issues
listed by the parent)

- For it to make decisions to "use less power" you need a controller for every device (heating/AC/etc) you want to be controllable - or something more complex if you want fine-grained control

Too complex for home usage, basically, where you want to turn your devices on and not worry about spot pricing
Storing your data on disk costs less money for the hardware per byte stored; storing your data in RAM costs less money per (transaction * byte stored).

On EC2, 6TB of RAM would be 25 r3.8xlarge instances, which is US$70 per hour. If your six-terabyte task is batch processing rather than interactive, that might be cheaper than spending a lot of time optimizing your software for spinning-rust relics.

Contrariwise, if it's an interactive computing task that you can do with AWS Lambda and which you can split into small pieces, 4000 Lambda functions each with 1.5 GiB of RAM, for a total of 6TB, will cost you US$0.01 per 100 milliseconds, or US$0.10 per second. Supposing your overall in-RAM computing task can be done with 10 seconds per Lambda function (a total of 40 000 CPU seconds (11 CPU hours)), can actually be parallelized to that extent, and that 10 seconds is an acceptable response time, then you can do it for US$1. I feel that this must be a mistake, since this is 700 times cheaper than EC2.

(Lambda surely has some total capacity limitations, but I imagine they're quite a bit more than 6TB.)

I am deeply unhappy about the move to such a centralized infrastructure for the internet, but at least this version of centralized infrastructure allows you to run your own code on the centralized servers, unlike the API vision promoted by Facebook and (mostly) Google.
> Anecdotal counterpoint. I believe your aggressiveness is due to the competitiveness, not the "violent" content of the game.

Abso-freakin'-lutely. I participate in a religious debate forum online, and when I find myself sucked into a conversation with a recalcitrant jerk who is actively trying to deceive people with slimy rhetorical tricks, I get so angry. And after I've had my say, I still find myself getting snippy with my wife and generally having a short temper.

I'd love to see the APA recommend against debating religion online. That would really help me improve my life and the relationships inside my family. Either that, or I show some self-discipline and simply stop participating. ;-)
How do these findings stack against the fact that violent crimes in the U.S. Have been trending downward for decades, while violent game and media sales have been trending upwards? (And parental awareness and involvement have been trending upwards as well...)

https://www.fbi.gov/about-us/cjis/ucr/crime-in-the-u.s/2012/...

http://videogames.procon.org/view.resource.php?resourceID=00...
>> In Afghanistan, an American Apache mowed down a platoon of British troops after being called in as air support and mistaking the troops for the enemy.

Do you have a link for this?

Here's a list I found that doesn't seem to mention w whole platoon getting killed:

https://en.wikipedia.org/wiki/List_of_friendly_fire_incident...
tex4ht does support math mode. By default it puts out pictures. But it is highly configurable. See for example https://www.tug.org/applications/tex4ht/mn11.html.
> Clearly the cars can pass EPA emissions requirements.

Yeah, going slower though...
Since this task Force is about violent media, it would be very interesting to see how film or music change people. Through out the 80s and 90s we had a bunch of studies linking movie violence to increase aggression, violence in kids, and criminal behavior. Music has also seem to been claimed as an risk factor for delinquency behavior in the last 100 years or so, and before that I assume it was books and poetry.

There does look to be a pattern here, so should we just wait a 20-100 years until games will be proven innocent and the next thing can be blamed?
I've seen exceptions masquerading as goto in the wild in multiple python codebases (and not because I added them). `raise HttpResponse(status=401, body="unauthorized")` inside some utility method is little more than goto exit in a lot of C code.
12 Reasons to Switch from Photoshop to Sketch
I'm pretty sure whoever wrote this article doesn't cook.

I'm a huge believer in data and its ability to make things better, whether for companies (seen for years with Business Intelligence software and whatnot) and now, with IoT, for individuals.

Problem is, now that we can gather thousands of data points about an individual (what exact time I woke up this morning, how well I slept, how long I brushed my teeth, the calories in my breakfast, what I had for breakfast, what time the sun came up, my self-reported mood, the length of my commute, how many stop lights I encountered...) we have no idea what to DO with that data. The state of IoT is ridiculous right now because every company is trying to cash in on it using the old model of marketing ("Surely if we know enough about our customers we can create ads that they will want to action on!") and this old model is 95% dead now that the majority of people get their content served up via the internet instead of newspaper/magazine and streaming instead of cable.

I believe that once the marketing field catches up with the way people are actually living and works in conjunction with the makers in technology companies coming up with products and solutions that actually make people's lives better then IoT will start to make sense. I have hope that this will happen... but am pessimistic about the timeline.

IoT means data, and to me "more data always means more better", but data is only as good as the questions you ask it and right now we're really, really bad at asking the right questions.
Comments on a Formal Verification of PolarSSL
>Locking away articles in native apps so people can't block ads isn't brilliant.

I'm reminded of a quote:

"After all, He-Who-Must-Not-Be-Named did great things — terrible, yes, but great."

-Ollivander

I agree the path mobile seems to be heading down is terrible.
I searched for this paper before it was published but couldn't find it. Turns out I just had to wait until they wrote it.
Mayor does not trump congress, unsurprisingly.
Or FakeRest for that matter. Why would you set up a server when everything you need is a browser ?

https://github.com/marmelab/FakeRest
France Rejects Google Appeal on Cleaning Up Search Results Globally
In order to produce a generic, you need to prove that it has the same efficacy as the namebrand drug. It's not the same thing as a full FDA trial, it's small-scale and you're basically just proving that you're ending up with the same active ingredient and that it has the same effects in patients (i.e. you're not doing something differently in the formulation/delivery that's causing problems or impeding the efficacy of the drug).

You can't do that for these drugs, because the only way to get ahold of the namebrand drug is from the official supplier, and they won't sell it to you.
It's mostly nonsense. You can invent comparisons like this, which are really just half-baked and not very convincing attempts at social science deconstruction, between any number of things and it may appear to be just as thought provoking.

I am sure that the generation that watched James Bond in the 1960's trusted their employers more than action movie watchers of the last decade but Bourne stories are about government conspiracies and the first book was written even before Iran Contra deals were known and president Reagan took office.
Maybe it was just a propaganda stunt to discourage domestic terrorism and push the learn to code movement? Maybe this kid doesn't even exist.
Kibana forked to support SQL and cross index joins in Elasticsearch
> and you're going to be personally responsible for its security

Well... but Android is a year long (8 years since the first beta) effort backed by Google (55k employees) and companies like Samsung (490k employees). They might spare a few people coming up with a scheme for data encryption that works?

And really, I don't claim it's easy, and I don't claim that I personally could come up with something even halfway resembling Apple's solution. But Android seems, unfortunately, to not even be trying.
Complexity is the bane of Security. Android has to work on a ton of devices with a ton of variation and it has its upsides and downsides. In this case many OEMs ship their own lock screens that update via Play Store and so for example none of my dozen Android devices have this issue - the stock ones are already patched and non stock ones didn't have it in first place. The downside is that the code has to cater to far more variations than something simpleton and that means more probability of security issues.

Given the scale and complexity I would say Google's done an acceptable job at Android security, but I do think they need to be even more serious about it. And it's not like iOS (remember lock screen bugs) or Mac OS X (remember password less logins succeeding?) haven't had their fair share of issues.
Sort of related (but the other way around): https://www.blockspring.com/
At what point do we go from "nothing personal, just business" to pure unadulterated evil?

Isn't there anything that can be done about this? It is not the first time this is happening and will not be the last unless something is done.
The Timeless Way of Building Erlang Apps
Compressing increases bandwidth, which is forever going to be at a premium. If you want to improve reception reliability, you put error correction on top of that. This is all off-the-shelf tech here on Earth, to say nothing of what aliens can come up with.

"Besides that, I can't imagine radio being used for interstellar communication at all. It's fine for "Is anyone there?" but unless your aliens live at geological rather than biological rates, it's far too slow for almost anything else."

Well, it's the fastest thing available unless you're basically willing to hypothesize magic. Anyone willing to do so is welcome to do so, and I'm serious about that; I just advocate that you be aware that you've switched to advocating magic. There's a difference between reasonable speculations based on real physics and arbitrarily advanced engineering, vs. new physics that despite all our research we still have little more than a whiff of, if that, and keeps crawling into ever more exotic energy domains to even peek at.
Apple pulls infected Chinese apps from iTunes App Store – Sep. 21, 2015
Could the markets be pricing in the fact that they can no longer trust what VW says?
Remember not to place these men in the same socio-economic and cultural categories you grew up in. This comes from the same culture that believes it is not homosexual to penetrate another man (receiving is what makes you effeminate to them). IIRC, this was the same for pederasty in ancient Greece.
This is a great implementation, thanks. For those of you who need this to be fast and achieve the theoretical bounds, you may want to do something like this using a finite-state transducer toolkit. Here's an example with OpenFst: http://www.openfst.org/twiki/bin/view/FST/FstExamples (halfway down under "Edit Distance"). (And OpenFst has a Python wrapper now.)
Recently there was a report around the pattern lock being the least secure and having the least amount of variation between passwords.

Edit: Unfortunately I can't find the specific study I was looking for, so I'll have to add my own [citation needed]
How #RepoKar Aids a Seller
Can anyone explain to me how this is different from China or Iran creating a mass censorship filter? One nation gets to decide what can and cannot be seen on the internet?

I guess if you took the most optimistic view and said the right to be forgotten mechanism would never be abused, then a nation might be able to regulate how articles about its citizens are shared online, since it is acting in the interest of French people.

But what if the City of Townsville passes an ordinance banning the use of French on the Internet entirely? Would Google have to comply with that law?
Given their track record - it was quite great actually.
Tammer : If you wrote an article about your experience, I'd love to read it.
Yes, it was. I've similar problem like she had. I started looking for some good solution. Didn't found anything, so I wrote it myself.

I twitted her, but no response from her. If you have contact with her and she still needs it, please let her now about Sheetsu.
Also preventing hair-loss, and prolonging erections.
https://www.youtube.com/watch?v=GA0l1JXhLaI
I wonder what how long the SJW mods are going to be running the ship?
Connect with US companies that have dev teams in Colombia and be careful with shady headhunters.
Search Engines Information Retrieval in Practice
Yes, Blockspring is really great software. I've one API endpoint (from Sheetsu) which is getting data via Blockspring.
The BBC historical documentary series "The Edwardian Farm" had some of this. It follows a year in the life on a farm set in the Edwardian era and the three documentarians are a historian and two archeologists. It's really well done and super interesting.
Have you tried Firefox Hello? Its pretty good.
My point is "Let's write more regulations" is "let's keep things the same and hope it turns out better".

It's easy to call for more regulations but it sounds a lot more to me like the core problem is a priority mismatch in enforcement. A lot harder to fix, but certainly step one seems to me to be to get people to stop calling for "more" regulation and start calling for the core problem of ineffective regulatory agencies to be addressed. Betcha if you took a look at what the relevant agencies were doing with their time instead of dealing with this, you'd be less than pleased.
The drill is, in such scenarios, to shift attention from the high price needed to be paid for one's survival to "let's help raise the money" instead. Give it a little bit, not far from now I expect this to get accepted like a lot of other existing ones.
The Many Ways I Avoid Ads
Treasuries and bonds wouldn't provide anywhere near the return you'd need to grow your retirement assets to a level you could live off them, and metals/commodities/real estate are still fairly volatile.
Apple pulls infected Chinese apps from iTunes App Store
Creating an Interactive Résumé Using Tableau
Lots of video game players coming out of the woodwork in this thread with low-content reckons.
I believe 999 is the third number.
'“To say that The Forever War is the best science fiction war novel ever written is to damn it with faint praise.” It’s one of the best books about war, period'

I'd probably raise that on Gibson. It's one of the best books, period.

"The protagonist, an almost-anagrammed stand-in for Haldeman named Mandella, is hurled across far reaches of the galaxy to fight a poorly understood, apparently undefeatable foe."

In that regard, it's as much a commentary about war today as it is the future.
"Drugs are health."

Only a sick (person/group/society/culture) would link them like this. Drugs are, in fact, dis-ease. They are the opposite of health.

Real food, real exercise, real work and real sleep. That's health. Drugs are at best dis-ease and at worst tools of predation and exploitation.
France tells Google to remove search results globally, or face big fines
"Cyrus explained softly to Adam the nature of a soldier ... He told his son of the sad dignity that can belong to a soldier, that he is necessary in the light of all the failures of man - the penalty of our frailties"

They exist because humans and our current behaviour are flawed, we haven't found better conflict resolution techniques.

The sad truth of this world is nothing is yours unless you can protect it. I know the reply button is right there but please stop spouting rubbish.
Partially evaluating a bytecode interpreter using C++ templates
In Unix and Linux, everything is a file
It contradicts his implication that Apple will force you to use iAd, at least the way I'm interpreting it.
Convicting someone of a crime requires proving all of the elements. Most crimes require a culpable state of mind (or mens rea). So the issue would be whether an individual has the requisite mens rea (recklessly, knowingly, etc.) These are very fact-intensive inquiries.

Having worked in the antitrust world, I saw lots of cases where mid-level managers and employees were engaged in anticompetitive conduct. The fact that their bosses demanded that behavior as part of their job function didn't absolve criminal liability.
I for one actually feel much more secure knowing that iOS is so secure that $1 million is considered the public value of an exploit. Vupen bought flash zero days for $30,000 in the past so knowing that iOS exploits are now valued enough to attract this kind of bounty makes me much more confident script kiddies and scammers will not be able afford to attack me. And lets face it, we were never secure from the NSA in the first place...
This is really useful, thanks! I can now use Github to navigate starred repos instead of a hundred disorganized bookmarks :-)
Volkswagen apologises for emissions scandal
The exploit/jailbreak must support and work reliably on the following devices (32-bit and 64-bit when applicable):
- iPhone 6s / iPhone 6s Plus / iPhone 6 / iPhone 6 Plus
- iPhone 5 / iPhone 5c / iPhone 5s
- iPad Air 2 / iPad Air / iPad (4rd generation) / iPad (3th generation) / iPad mini 4 / iPad mini 2

So did i read this correct and the exploit must be backwards compatible in order to get the full bounty?
How is this any different than just getting the json feed for the sheet? I find it much more flexible.
Very cool!

> Entrepreneur crowdsources decision to quit Silicon Valley

Perfect :)
Where did I say anything about war? The military is always a big expense.