skysight-inc/HackerNews huggingface dataset:
I disagree. I am a physician training to be an electrophysiologist (cardiologist that sub-specializes in the electrical conducting system of the heart). Without significant equipment it would be impossible to disconnect the leads of an EKG without causing enormous irregularities in the read out. Even small movements, like subtly shifting the body, causes blatantly obvious noise in the EKG baseline. If these baseline changes weren't present, as the authors state, then it is unreasonable to assume the yogi removed the leads.
What a boon this is for Turing. I'm willing to bet most of the public will not realize it's not the same drug from the earlier price hike story.
>In general donating proceeds immediately solves accusations of self-interest

Well, you still get the tax deducations, don't you?

Plus the goodwill ("here I gave all those to charity") bought with other people's money.
Well of course. Any attempt at helping one person hurts another person. If you give someone a free house, you put a builder out of work. If you give someone free food, you put a farmer out of work.

But I don't think it's a zero-sum game. I think the total utility generated by free food is worse than the disutility of the farmer losing his business. Now those people have money to spend on other things that they would have spent on food.

Protectionism benefits producers at the expense of consumers.

Of course ideally you wouldn't send food directly, but just money, which they could use to buy food, or whatever they need.
Along similar lines, I just made this library a couple weeks ago to describe data validations programmatically (i.e., one JSON to validate another JSON document).

https://github.com/MalcolmDwyer/json-predicate
Presumably I will be in a state of dis-ease ... I will be sick in one or more ways.

You're making my point for me.
I don't get this, the drug is available from Sigma[1] for $51.50 per 250mg, with a dosage of 50-75mg per day for a patient. So clearly someone can make it more cheaply. I get that Sigma is research chemicals not medical grade, but seems to me someone could figure this out. FDA approval must be the issue.
[1] http://www.sigmaaldrich.com/catalog/product/fluka/46706?lang...
As someone else mentioned, Litecoin. Not in passwords but in "mining" (proof of work). It resisted GPU for a while until it didn't. Although the difference between CPU and GPU was not big (much smaller than with SHA256). The work factor was too small and it couldn't be changed easily. After 4 years, though, nobody "cracked" it.

The work factor of a password database can be changed easily, either by re-hashing every time someone with the old scheme logs in, or by hashing all the hashes more.
The project heavily relies on lodash for it's implementation actually, so you can of course do it straight with lodash, however the benefit is that you don't have to write any code to produce complex searches (with multiple nested levels of $or and $and), which would require a lot of conditionals if done straight with JavaScript.

Another benefit (which was the reason behind the implementation), is that we can stringify the search object to easily persist and share it, which would not be that easy with plain code.
Hemi 2: Simple, Portable Parallel C++
Being obsessive is a great when you happen to be obsessive about the right thing. Obsession is a force multiplier but when applied to an idea that sucks it merely keeps you working on the wrong thing past any reasonable point. It is a two edged sword.

True obsession is not something you get to choose, it is something that just is. Steve Jobs did not wake up and decide he was going to be obsessive about something. It was just the way he was.

So I would contend you cannot choose to be obsessive and you cannot choose what to be obsessive about. Obsession is not a logical decision you make. Ask an OCD suffered if they chose to wash their hands 20 times a day.
> Someone like me is not "just a niche". It's also the type of person that recommends (evangelizes even) a browser or app to every single friend he has. Don't forget that's exactly how Chrome "beat" Firefox, if I can say that - by winning over the evangelists.

You're saying "don't forget that..." as if that was an established fact, but did studies confirm this? I doubt it. I don't have numbers either so that's only one feeling against another, but I think you overstate the importance of evangelists / "power users" like us. There are other factors that (to my eyes) seem much more likely to have pushed users towards Chrome, like:

- Giant physical ads in subways (in London, Paris, Amsterdam, Berlin, maybe others?).

- More ads on the web.

- Very visible hints to switch on high-volume domains like google.com and youtube.com

- Chrome having a mobile story earlier letting users sync their bookmarks & passwords across devices. By comparison, Firefox (with Firefox Sync) took some time to land on Android, and is barely arriving on iOS.

- The sorry memory-hungry, inefficient state of Firefox when Chrome was young and slim (which was fixed since then, but hurt the Firefox brand a lot).
They were powerful desktop workstations (first of their kind!) They had up to 40 bits per instruction word in a tagged architecture, so a byte could be identified by object type without having the program say it outright. The processor was a stack machine that ran a bytecode compiled version of Lisp that did type checking and dispatching, in hardware, at runtime. Some of them had very powerful graphics boards that did all kinds of rendering.

tl;dr: They had special hardware that aided in dynamic language processing, like 40-bit words and hardware dynamic dispatch.

And it would not help you at all today because the most prohibitive part of the system is really the size of the CPU silicon wafer and its efficiency, and C is faster than Lisp and people are totally okay with writing code in it.

EDIT: RE: getting into Lisp in a big way: https://web.archive.org/web/20080709051856/http://www.lambda... tells you all you need to know. Specifically:

"And the problem with Lisp? The answer is tailor made for the minds who program it. It is the koan of Lisp.

"The answer is that there is no problem with Lisp, because Lisp is, like life, what you make of it."

Your Lisp code (unless it's an emacs tool) will never work with anything or anyone else. You're invited to write everything from scratch, and doing so is easy; it's just difficult for anything you do to be used by or with anyone else's code.

Lisp is so beautiful, and yet so dangerous.
> "our redundancy all runs through the same conduit and ninjas chopped it in half during a new buildout."

You can just consider that as a failure of the whole datacenter.

The ninjas could just as well chop all the external network connections, which would result in actual datacenter failure (from a client/service PoV), so it shouldn't increase the rate that much.
It does look like we are entering an age of 'trickle down medicine'. Sad to see after such humanitarian improvements in the West post-WW2. Even Places with great universal healthcare like Australia and UK are increasingly looking to privatise. This blows my mind as we can look at the US to see where this direction will take the system.
There are so many people that there will definitely be enough people to continue tradition. Usually, it is more convenient to marry someone who is from the same state, so that is what ends up happening (also: in, Arranged Marriage, the suitors are generally from the same state and maybe caste).

However, there is also a lot of intermingling...but I don't see it becoming one homogeneous race (like the Han Chinese) anytime soon.
Can we always trust wayback for this resource? It'd be real nice if someone could tar up maltmaniacs.org and throw it on bittorent.
How not draconian of the FCC. /sarc. I feel like Freedom is being banned everywhere by every western government.
Technological Unemployment and the Value of Work
Is this the CEO who was trolling on Twitter?
Strategy Consulting is being disrupted by data startups
Looks cool, I haven't heard of it. However I don't think I could use their querying language separately from the ORM.

Our use case for Queryl is to filter array of objects based on different criteria, but I guess an extra benefit is that the query language is completely decoupled from its usage, so anyone can use it in their own projects for different needs.
Check for new iPhone malware
No, but capitalists follow the incentives. The surprising thing is that, although nobody likes this, there isn't yet some tax or something to make selfish capitalists avoid doing it.
I'm by no means a user of an actual Lisp Machine (would love to be though), but I can offer a few anecdotes I have picked up.

Firstly, computers back then were so much slower than they are now that the speed boost from running native versus interpreted is definitely nothing to scoff at.

Secondly, I now use StumpWM, a tiling window manager written in Common Lisp. This means I can connect to the lisp process that runs my window manager to inspect it, debug it, automate it, or make changes live. Now imagine you can do this with the entire machine!

Thirdly, and finally, not everyone is aware of the etymology of "car" and "cdr":

* car (short for "Contents of the Address part of Register number"),

* cdr ("Contents of the Decrement part of Register number")

* cpr ("Contents of the Prefix part of Register number")

* ctr ("Contents of the Tag part of Register number")

The original lisp implementation was on an IBM machine that had 36 bit words broken into 4 parts: the address register (15 bits), the decrement register (15 bits), the prefix (3 bits) and the tag (3 bits).

Lisp started out very close to the machine, for being such a high level language!
Plus, OSX needs a UIKit-style revival, especially with all the recent grumbling about the Mac App Store. Having just written an OSX app after doing UIKit for several years, it feels incredibly old and clunky in comparison. Even simple layer transform animations are for the most part unsupported!
XcodeGhost iOS malware
Does anyone know under what circumstances changes to software can significantly impact energy consumption? I'm thinking of this from the perspective of the environment and of impacting climate change. How often is that considered, outside of mobile platforms? What are the largest opportunities, if there are any big ones?

For example, TCP is so widely used and affects so many machines with each transaction (i.e., the endpoints and everything in between) that I'd guess that a tiny increase could make a large impact globally. Or there might be other software where there's an opportunity for a large improvement.
As far as I know Shimano and SRAM are compatible,

My understanding is that they aren't, at least where we are talking about indexed shifting (which is pretty much everything these days). The amount of cable pull per "click" is different between SRAM and Shimano, which means you can't use a Shimano shifter with a SRAM derailleur. Or maybe that's just true in MTB world and not road bike world, not sure.

OTOH, chain, cogs and chainrings are pretty much compatible, at least within the constraints imposed by the changes in chain width to accomodate the newer, denser cassettes. Eg, 10 speed chain or 9 speed chain won't work with an 11-speed drivetrain.
Here's a talk from Kalman Reti using a Lisp Machine.

http://www.youtube.com/watch?v=o4-YnLpLgtk

pros: everything is lisp structure, no text serialization/deserialization to communicate between parts of the system.

cons: see above.
exstudent2 made some really good points and you just answer it like an invocation in the church.

Seriously, we're not in the church here. It seems like a sensible matter to you and you seem angry, which will change nothing. So take a deep breath and go out to change your mind. There's nothing to win in this conversation and we will all be at the same place tomorrow. Take a break.
"How do you find an honest and truthful workplace?"

Make it yourself. Another way is find people where the intersection of technology and these attributes collide. Hacker spaces are a good place where technology is made unburdened by commerce. When money is introduced though, that's where you'll need to pay extra attention.

Honesty, truth and money mix like oil and water.
Maybe it was, maybe it wasn't. And maybe a 100% increase of price will cover the alleged loss, and then some. Regardless, anchoring at its finest.
One of my favorite quotes (wish I knew where it originated):
"I can't make it run any faster, but I can make it do less."
Really looking forward to some sort of interoperability between browsers plugins between Chrome and Firefox. That would be really great. However my intuition tells me thats going to be quite difficult. Not only from the technical point of view but also the perspective of developers of existing extensions... Would there be some common extension repository? What if someone takes somebody else's Chrome extension and puts it in the FF repo as his own, etc...
A smoother Quiver (http://happenapps.com/#quiver) for Windows
"SES: You could use it to send a newsletter if you wrote all the code, but that's not a great idea."

As the co-founder of a startup doing exactly that (https://emailoctopus.com), I respectfully disagree!
Capitalists hiding behind patent laws enforced by the states, which isn't really the purest form of capitalism. And usually, there is no such thing as a well intentioned company, once they reach a certain size they become profit maximizers before anything else.
What I Learned from Job-Shadowing My Husband
Wonder how this dynamic plays out in SaaS products that have network effects. For example in a B2B communication service (like ours) you want users (in one signed-up account) to be able to communicate with other users (who have not signed up) and not have THOSE users have to pull out THEIR credit cards since they were not making an explicit decision to join.

We've settled on 3 free users in a business account to facilitate this viral effect. (3 being the smallest group greater than a pair :). Wonder if anyone has any thoughts on this?

Will update you on our experiences as we are launching soon.
Sane Build Systems
Would you accept the basic notion that items bought in bulk cost less in per/unit or per/volume terms than individually packagaged items as evidence?
Rather interesting that clicking on that link, I see a banner above the content saying "you have an adblocker installed, please pay for our content with cash".
Weird. I'm in the UK, and just chose the 'I want to cancel the order' option.

The email confirming my request and the email confirming the refund had been accepted literally arrived in the same minute.
Don't forget James Randi.
Box, LinkedIn and WhatsApp share open source advice
A change to intellectual property laws could also fix the problem. The government could allow others to sell the drug but give a percentage of their revenue to the rights holder.
I'm sure there are folks (archive.org?) who would love to help you make digital copies of all those tapes for historical purposes...
A Pow clone in Rust
Charlie Chaplin’s Scandalous Life and Boundless Artistry
Based on the article, it sounds like Purdue University's research arm was serving more-or-less this function, but because they were losing money on regulatory costs, they accepted Rodelis's offer to buy the rights. Now, Purdue has the rights again, and is aiming for a more sustainable price.
Security is everyone’s business
"lisp machines were made by (pretty much) a single company (symbolics)"

Actually, there was a rivalry with another company that's really worth mentioning, LMI (see https://en.wikipedia.org/wiki/Lisp_machine#Commercialization...)

"the amount of engineering effort that went into these machines far outweighs what you might get in a modern computer" - "the computer in front of you was probably purchased for a sum between $100 and $1000, and it represents $100 to $1000 worth of engineering. the kind of computer representing hundreds of thousands to millions of dollars of engineering are, well, pretty slick"

That's a pretty ridiculous comparison. The design of the intel chip in your cheap computer, and the fab process to manufacture it, really are worth billions. It's just automation and scale that brings the price down to a couple hundred.
A Lisp Machine today would be an anachronism. Hardware type tagging could be useful. But list efficiency and manipulation would likely be futile. Today, cache is king. Which means, linked lists are out. CAR/CDR? Let's not.

The glory days were not that glorious. There are stories out there of runaway garbage collections, that grinded on for days. Today you get garbage collections in your web browser that would embarrass any Lisp Machine ever built.
> The straight line on the ECG persisted till the eighth morning. Then, to our astonishment, electrical activity returned about half an hour before the pit was scheduled to be opened. After some initial disturbance, a normal configuration appeared.

Sounds a bit like he disconnected and reconnected.
Is it reasonable to accept causality here?
Show HN: Started an educational python JIT completely in python
I just started writing a smaller POC kind of JIT entirely in python (mainly for educational purposes). I know of the big players (numba / pypy / pyston) :). This is just my attempt to make it simpler to read and understand. Any feedback will be welcome. Also contributions are welcome.
And that is called... a royalty! What the patent system was supposed to be for, in fact.
Rankings of programming languages by Stack Overflow + GitHub stats
> Foot showed that much of it rested on the evidence of one extremely dubious witness called Mr Giaka who claimed to be high up in Libyan intelligence. In fact he was a mechanic in a garage who serviced the vehicles for Libyan intelligence - and he had been paid hundreds of thousands of dollars by the Americans. <

And a decade later the same crap would be used to construct the paper tiger known as al-qaeda.

Frankly ever since the fall of the wall DC have been looking for monsters to fight...
Maybe a chop-shop with a drive-in faraday cage?
I came here to note this to, but the NYT story (http://www.nytimes.com/2015/09/22/business/big-price-increas...) puts it in a broader background:

>A huge overnight price increase for an important tuberculosis drug has been rescinded after the company that acquired the drug gave it back to its previous owner under pressure, it was announced on Monday.

>However, outrage over a gigantic price increase for another drug spread into the political sphere on Monday, causing biotechnology stocks to fall broadly as investors worried about possible government action to control pharmaceutical prices. The Nasdaq Biotechnology Index fell more than 4 percent.

>"Price-gouging like this in the specialty drug market is outrageous," Hillary Rodham Clinton, a contender for the Democratic presidential nomination, said in a tweet on Monday. She said she would announce a plan on Tuesday to deal with rising drug prices.

Basically, people were spooked by the prospect of regulation, which a major political candidate for President said she would be announcing tomorrow.
In fairness it was:

1. "hey, this guy wants to buy this drug that we are producing as a public service but losing money on",

2. "oh shit - he raised the price to an astronomical figure and now we all look bad. oops",

3. "we're getting the rights back before this turns into a giant PR nightmare. while we're at it, let's raise the price to a sustainable level."

The article doesn't make it sound like there was any malice on Purdue's part.
Shutting down their competitors.
Occam also suggests that there are little people living inside my tv and that everybody around me is a thoughtless automation merely imitating sentience.

What you are citing sounds more like convention.
A couple of things might influence this observation:

1) Your definition of what is fast changes. Downloading an MP3 in 5 minutes felt really fast in 1998, but really slow today.

2) What we expect chrome to do keeps increasing. Since Chrome was so fast, people started creating webpages that had to do more (because they could!) It is a form of Induced Demand (https://en.wikipedia.org/wiki/Induced_demand)
Yes, it has.

Non Fusion things to think about.

RF systems, think about WiFi etc. Wireless data channels with the capacity to send hundreds of megabytes per second. Computational radar systems, magnetic resonance imaging and about a half dozen different ways to image things at the atomic level.

Materials science, building airplanes out of carbon and glue. Building skyscrapers as pre-fab blocks. Sapphire glass, tempered glass 10x harder than anything in the 70s.

Vision systems and vision equipment, from cameras that have megapixels of resolution costing just a few dollars, to dedicated object tracking and identifying sensors. Lidar as a thing.

Information retrieval on a scale that was not even imagined in the 70's. Trillions of documents accessible through a simple network protocol.

Precison machining, additive manufacturing, 3D printed rocket engines.

Privately funded space technology, from micro-satellites to booster systems.

Textiles with the feel of satin and the stopping power of ceramic plate armor. Carbon based conductors made out of graphene.

Internal combustion engines that go three times further, or have the same power with 1/3 the gasoline required.

Solar power systems that can provide 100% of the needs of a single family home for less than the cost of re-roofing.

One of the interesting ways to think about it are what tools enabled what technologies. For example the ability to make hardened glass at scale gave rise to the ability to have large screen televisions. You could imagine a 55" television in the 70s but you could not cost effectively manufacture one.

Another way to think about it is how computer games today on the PS4 or the Xbox would be inconcievable on the DEC-10 or the IBM 370 in the 70's. The GPUs themselves were simply to complex to imagine, much less design, simulate, and fabricate. Get your hands on state of the art "demo reels" from the Siggraph conferences in the 70's early 80's. Compare that to Renderman. There is no comparison.

I think as Peter gets older and has participated in bringing more technologies from concept to product, he will evolve his thinking where he understands the entire stack of things that have to be in place for something to occur, this "eco-system" if you will, which has to all be present before progress can be made. You can't study diseases effectively without microscopes, you can't analyze genetics without the polymerase chain reaction and a way to sequence DNA.

Fun to try and go through your house or office and not use anything that didn't exist in 1975. But sometimes you can only see the distance you've come when you look back to where you were before.
"Secondly, I now use StumpWM, a tiling window manager written in Common Lisp. This means I can connect to the lisp process that runs my window manager to inspect it, debug it, automate it, or make changes live. Now imagine you can do this with the entire machine!"

A million times this! Such a machine, end-user-programmable from the ground up, is a real 'bicycle for the mind'.
$1m bug bounty offered by 3rd party for iOS9 explots
British designers pin hopes on growing demand for UK-made clothing
Somewhat strangely, the description reminds me a lot of Active Directory Certificate Services.

https://technet.microsoft.com/en-us/library/cc731564.aspx