skysight-inc/HackerNews huggingface dataset:
The p-value is the chance of a false positive. But you don't know what the rate of true positives is, or the rate of false negatives.

In a world where there are only false positives and true negatives, and people publish all positive and negative results, then reproduction of a paper should be 95%.

But the reproduction rate when there actually is an effect is not 95%. Depending on sample size, I might get a true positive 20% of the time and a false negative 80% of the time, or I might get a true positive 99.8% of the time and a false negative .2% of the time.

So the average reproduction rate, where an effect actually exists, can be almost any number between 5 and 100. There is no reason to assume it will be 95%.

So the average reproduction rate, where some effects are real and some are imaginary, will almost certainly not be exactly 95%, and that is not a problem in and of itself.

(And when you talk about an average p-value of .05, that sounds like only publishing positive results, which is blatantly going to fail reproduction. 100 false hypotheses -> 5 publications, all false positives -> 5% reproduction rate)
> "So there’s something going on that makes it hard to stop for very good neurological reasons. So then, do you want to call addiction a disease? Well, maybe, then you’re getting close I think, because you could call it a pathology I guess."

Science left the room, this is semantics. HN's comments here are orders of magnitude more valuable than TFA. This reflects the thinking of a book salesman, not a doctor of neuroscience.
I do not have a personal grouse against Wolfram, but it takes a level of self-importance to (re)name every product of your company after yourself, even if you might be coming up with some key ideas and the vision. Eg: Wolfram Alpha, Mathematica --> Wolfram Language, etc.

It seems wrong for him to take sole credit for what I'm guessing a talented and hard-working team at Mathematica has achieved together, over the years.
Uber’s Long Drive into Google’s Self-Driving Moonshot
My own experience with IKEA is that they constantly remove quality products from their offering. Time to time there are some pearls but the trend seams to be the reduction of prices and the quality as result.
That's a post hoc justification, without historical basis.

The earliest Egyptian maps show south at the top of the map.

European maps in the Middle Ages used east. Not only does the sun rise in the east, but east was important in Christianity; eg, churches were built facing the rising sun and people buried with their head towards the sun. We get our term 'to orient' from the importance of knowing where east is.

At https://en.wikipedia.org/wiki/Tabula_Rogeriana you can see an Arab map from 1154, with north at the bottom. "It remained the most accurate world map for the next three centuries."
Very interesting article. One thing that it makes me wonder about is if there's a mischaracterization of the concept of "immediate environment" with regards to the human mind in a modern society. Things like future job loss, reduced earnings, being forced to leave one's home, lifestyle and societal status downgrades, etc. may not be in the immediate _physical_ environment, but they are ever-present in our _social_ and _economic_ environments. For example, thinking about how you badly need to get rich sooner than later because ageism is likely to be a factor in the not-too-distant future isn't equivalent to thinking a lion may be in the room, but it doesn't mean the threat isn't just as - or in this case more - real. It's just that the scope of "immediate" and "environment" is shifted for those with high neuroticism. Something that could happen in just a few years is "immediate" enough to worry about.
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My daughter had cancer. Fortunately, she is still clear, but I have a pretty good idea what you are going through, both emotionally and with respect to finding qualified information. For what it is worth, I am very sorry your family has to go through this diagnosis and whatever comes next. Cancer sucks.

From everything my wife and I could find, there is no such clearinghouse that is publicly available for what is the "best info," or for readily comparing studies. Because the research on treatments is changing so rapidly, it really does take a scientist (read: your oncologist) to filter through the different papers and compare the stage-based 5y EFS rates, review risks of that treatment, and figure out the pro and con to your relative's situation to determine the best treatment protocol.

This is further complicated by the fact that not all protocols and studies are publicly available. Some groups actively hide information from public view to prevent the "Web MD" effect. The treatment protocol we ended up with for my daughter is widely used and studied in some countries, but was never before used at the hospital we were at. We felt very comfortable with it when we reviewed the literature with our hem/onc, but as the doctor was part of a particular oncology group that shares research and studies, only they could find the critical information. At one point I was looking for more in-depth details, and because of the restrictions by the oncology group, our Dr had to be very careful about what they could and could not show us. I could read some studies in their office on their screen, but could never get a copy of the PDF.

Trust in your medical team. If you aren't getting the information your family needs, ask for more. If you still feel like you aren't getting enough information, then maybe re-evaluate if you have the right medical team.

Now, all of this is written as if you get to have contact with the medical team. If the close relative doesn't want you to have access, please respect their right to pursue the treatment your relative and their doctor have selected as most effective for their highly individualized case. Support them in their quest to get the right information, but don't pry and second guess. I come from a family of medical scientists and medical professionals, and believe me, there can be a very fine line between curiosity and help, and prying.

Good luck to you and your family.
Regardless, plug-in hybrids do reduce greenhouse gas emissions and gasoline used. They were a nice stop-gap until battery tech has caught up, and now that it has, you'll see people move on to fully electric vehicles.
Refueling times don't tell the whole story, because you aren't necessarily waiting for it.

This is especially true with home charging. 10%/hour means you plug in when you get home in the evening and your battery is full in the morning. While technically it might take some hours to charge, in terms of your wait time it's zero.

On a long-distance trip, the possibility of actually having to wait for the car is higher. But if you time charging to coincide with meal and bathroom breaks, you can often put that time to productive use as well, in which case the wait time is once again zero.

It only takes a few minutes to fill up a gas car. But that time can't be used for anything else. You're waiting a few minutes no matter what.

For an average driver with home charging, the average time spent waiting to charge an EV will be much lower than the average time spent refueling a gas car.

Don't get me wrong, it can be a problem if you go on a longer trip and things don't line up right. And it's something I'd love to see solved. But all too often I see people equating charging times to time spent at a gas station, when it's quite different.
Inspirational technical books that are not technical
Server: header makes people gone mad?
Ask HN: Part-time, remote jobs?
Given how favorable the labor market is for software engineers right now, one would think that there would be a wide range of options available to us in terms of how we do our work. After all, as long as the results are there, the time and place of work should be of little consequence, right?

However, most advertised positions for seem to be 40+ hours of on-site work, which is quite the opposite of what I'm after. Why is there not a trend to work less instead of taking more money? Is there any demand for part-time remote work? Wouldn't employers significantly expand their hiring pool (read: cut costs) by going after all the talent that is not willing or able to rent $3k/mo studio in SoMa?
Chimerica and the Central Banksters
I learned this when I was younger. People thought I was weird.
It is back online. Sorry the link got shared a lot over Facebook it brought down the website.
I think this is what electronic science notebooks should look like.
> It's major refactoring when so much stuff directly includes 3rd party CSS and script, or just injects static CSS and JS in to pages inline.

You can still use CSP, and whitelist specific third-party domains. (There's no way to whitelist inline code, though, and if there were it'd be more work than eliminating it and moving it to files.)

But the refactoring is well worth doing. By eliminating inline JavaScript and off-domain JavaScript, you eliminate the possibility of script injection. And directly including third-party JavaScript (or CSS, which can include JavaScript) opens you up to various kinds of attacks.
No cabledrum robots on the streets that roll out to meet your car halfway..
Carl Steadman on twitter: https://twitter.com/guydeboredom
I prefer mlocate to locate, as it rebuilds the index in a flash by diffing and by paying attention to modification dates when traversing, so you can run its updatedb more frequently without a noticable penalty.

That said, mdfind is terrific -- it's index is, as you suggested, always upto date, and it doesn't just index file names, but also content.
To counter this, I actually wrote a "Dont break the chain" app[1] that pulled contributions from all my local projects (since i have some that are not yet on github, some on bitbucket, etc)

The idea was that I'd be happy if I made progress on at least one of them in general. Of course, I didnt finish that one either :)

[1]https://github.com/vinodkd/dbtc
North is up because most of human's civilizations especially the Western ones have occurred in the Northern hemisphere, where water generally flows south "down" towards the equator. So in Egypt where the Nile Flows North, the Upper Nile is in Southern Africa, while the Lower Nile is in the North.
I went through this - I was a caregiver for my partner who was diagnosed with GBM. It's a terrible disease, and by terrible, I mean most people have no idea. It's one of the diseases with an extraordinarily poor outcome ratio (under 5% past 2 years, depending on age, young people might be at 25% two years 5% three years) and terrible end of life scenarios. I can only hope that your family member is fairly old, it's a heartbreaking disease for someone young.

There is a standard treatment path for GBM. whole brain radiation with temodar, then a few other choices on recurrence. Any regional hospital / cancer center can do this.

If your family wants to get more aggressive, they have to get into one of america's cancer centers. For GBM, I remember UCSF, UCLA, MD Anderson, Duke, Sloan Kettering, Boston Women's ( Mayo never came up for GBM in my research but maybe I'm misremembering ). My method for finding these centers is to scrub the clinical trials database and see who is offering what trials.

In terms of how to ingest all the data --- I'll tell you what I did. I sat in UCSF's library for two days and read like a demon. I read all the articles on GBM going back 20 years, and when I didn't understand a term of concept, I pulled a textbook. As a "hacker" you'll find drilling down on one disease isn't _that_ much information. I was then capable of having realistic and high bandwidth discussions with all of the doctors involved, including some of the nations premiere neurooncologists.

Right now, interesting clinical trials focus around immune system treatments (monoclonal antibodies). That wasn't around when I did my thing, and my info is all out of date.

If you live in the bay area, you might have a friend at Genentech. You should scrub your linkedin friends. They're at the front of most oncology research, and main HQ is at the oyster point office.

Your local doctor(s) won't like moving to a regional cancer center. It's a terrible fact, but they'll tend to drag their feet, tell you won't get personal service, make record transfer difficult, and claim they can do the same treatments at home. Part pride, part truth, part profit motive.
As another note, the product page of IKEA website can keep Firefox on 100% of CPU utilization. The same with Chromium.
I would add that having stripped out the domain specific part prior to these words of your's:

"[... people] who have good problem-solving skills, a business orientation to doing work that meets customer needs and builds a profitable company, and good written and oral communication skills."

Your following sentence is also true with the modification I've made in brackets:

"There is a severe shortage at all levels of employment of [people] who meet those other requirements."

With programming skills or not, people with these characteristics have always been rare. We can gather lots of them for a while for massive nation efforts like the Manhattan Project (something I've been studying in detail for the last few months), but in normal times all organizations, from Google to just another startup, have trouble finding these people who will make or break their ventures.
Yes, that was a hydro-generation dam.

However, it is simply not true that hydro-pump storage never has a dam.

See: https://en.wikipedia.org/wiki/Pumped-storage_hydroelectricit...

https://en.wikipedia.org/wiki/Ffestiniog_Power_Station

In fact, when you look at the list of pumped storage stations, the vast majority of them have dams:

https://en.wikipedia.org/wiki/List_of_pumped-storage_hydroel...
I don't agree with your logic and think you need a more nuanced sense of humor. Spying on someone remotely? Fireable offense. Remotely kicking off speech utils between people on a team once? Not so much.

Disclaimer: I have managed tech teams before. It is better to forgive then have knee jerk managerial reactions.
Lathes and Turing completeness
>In a world where there are only false positives and true negatives, and people publish all positive and negative results, then reproduction of a paper should be 95%.

This is the world p-value assumes and is therefore the only one worth considering in relation to my comment.

If an experiment is not well-formed then of course you won't see reproduction at the expected rate. This is what I'm referring to when I say that the low reproduction rate points to deep, fundamental flaws in the experiments.

I agree that the reproduction rate will never be exactly 95% (or 1 - p) due to the discrete nature of experimentation [that's why I used a ~ in front :)], but the reproduction rate of a well-formed experiment should very closely track 1 - p.
uptodate.com is a standard medical reference used by many doctors. Perhaps start there?

Warning: it's a subscription service.
Show HN: Public email API for your apps, sites, contact forms
My brother in law was diagnosed with the same grade GBM, over a year ago. He was given 4 months to live & told his tumor was inoperable. He traveled to NYC the day after diagnosis trying to seek consultation with some of the top neuro-oncologists in the world at NYU, Penn, & Sloan Kettering (where the surgery was performed).

He was 32 at time of diagnosis, he's an inspiration to me every day to persevere through any of my struggles that I perceive as difficult.

My advice, which was my sisters strategy in keeping her husband alive, is to get as many opinions as possible about the most aggressive treatment strategies available (depending on tumor location, etc) and formulate a plan to try and eliminate as much of the tumor(s) as you can. The occurrence rate on these grade tumors is insane, try anything you can to get into an amino therapy clinical trial, or any other trials that they may be eligible for. My brother in law participated in the MK-1775 trial.

I built a little WordPress site for him: youcanthurtsteel.com

Please email me, or message me if you have any questions that I can answer from my perspective & I'll do my best to convey what my family has learned about this terrible disease.

Here's a youtube clip: https://www.youtube.com/watch?v=8Fo2uNqKMR8

Also, http://www.voicesagainstbraincancer.org/ is one of the best foundations that you can help raise awareness for. He's become an advocate for their cause, http://www.voicesagainstbraincancer.org/james-j-hanson-bio/

Your friend,
Nick
Just a trawl through old diet advice, but what stood out to me was the crappy advert (something about how many triangles I see). I cannot for a moment image the published paper accepting some crappy trawling / phishing ad for its sunday edition - even if they ponied up the cash.

How has advertising got so bottom-feeder and no one seems to care - this is your brand guys !
Since it died suck.com has been my canonical "poke the public-access WiFi gateway so it'll send me to its clickthrough agreement page" URL, since at least at one point that usually worked via DNS poisoning and I wanted to make sure it didn't poison a domain I actually wanted to visit for real. So I wound up seeing the page relatively often even recently. I was very sad when I saw it had turned into a parking spot sometime earlier this year. :/
For those not already aware, cmd &. is the standard shortcut for "stop". Works for all sorts, from web page loads to Xcode builds.
HN uses x-frame-options:"DENY" to good effect which takes care of a fair number of click-jack tricks, it also uses strict-transport-security.

But there is only so much you can do with headers, the real risks are in the documents themselves.

How about a <nojs> </nojs> pair in the primary document disabling any kind of javascript execution in the space between the tags. And those tags should only work in the primary document.
Toxic work environments scare away smart people. Cynicism trumps innovation. Noise obscures signal. So, yes, meanies have a measurable impact on the health of a community. If every post on HN was toxic vitriol, would you be here? This isn't a thesis. I'm not suggesting this is Bitcoins only problem but that it's a very serious problem hackers tend to overlook.
I was unaware that there was such a thing as a "CS degree in iPhone or Android development", and if there is - it's a horrible misappropriation of the term "CS".

On a related note I strongly believe that taking a 12-week course or a bootcamp in [insert latest flavor of the day here] does not allow you to call yourself a software engineer or a computer scientist. Anecdotally, I've noticed a marked increase in that attitude (and another term I intensely dislike - IT) since moving to New York. This attitude grossly misrepresents what it means to be a software engineer or a computer scientist, which is much more about an approach to analyzing and solving problems using a combination of experience and first principles in face of tradeoffs, than using specific tools or languages.

Rant over.
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Introduction to Quantum Computing
With most fuel injected engines, the injectors turn 'off' on deceleration until ~1000 rpm where they kick back on.
I think you misunderstood his argument. His point is that you won't switch from Facebook because your friends won't switch, while your friends have no bearing on your choice of search engine.
One cause of traffic is TLC cars roaming the streets slowly looking for pickups. If Uber can show that their cars don't wander as much, that may show that Uber is helping traffic. But the current data set doesn't have that info, only your internal data would have it.
Sure, where do you think Oracle gets all their revenue? :) I mean, interbank transactions go through a clearing house like FedACH, but even that is just a remote RDBMS.
Thanks for your feedback.
"Lintukoto" (Home of the birds) was a warm place where earth raises to meet the sky. It was southwest from Finland and up. And of course "Tuonela" (Home of the dead) was northeast and down.
According to wikipedia, american may learn D'Nealian https://en.wikipedia.org/wiki/D%27Nealian which is not terribly different from what is taught in France (Écriture A : https://fr.wikipedia.org/wiki/Modèles_d%27écriture_scolaire_...) or from Deutsche Normalschrift (whose t is more readable than other german scolar scripts).
The flood of cash into tech startups means pay is going through the roof
Recommend "Amphetamine" as an alternative. More features and kept up to date with bug fixes and improvements. I am not affiliated, just a happy user.
libclang is pretty amazing for that
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Why the rich love Burning Man
If this interests you, there is also https://cdn.polyfill.io/v1/docs/ (https://github.com/Financial-Times/polyfill-service), backed by FT.
Yeah and that's like the least worst thing that can happen. JS CDNs are a bad idea.
There is a wide range of comfortable shapes people can make using whole hand motions, but arms have a vastly more momentum than the tip of a pen. So for example the center of an uppercase E is much harder to do using whole hand motions if you need to stop your arm motion in the middle to add details. It can be a fairly direct tradeoff between legibility and readability. Scripts that are less legible because they lack detail can quite simply be far easier to pull off.
There is binary code, and of course you can represent it with fingers. Nobody does this, though. That is to say, there is no cultural practice of "finger binary". Finger binary is not a "thing" that's "out there". Whoever wrote this Wikipedia page just made it up. The Wikipedia must document the existence of real things that are out there, and can be properly referenced.

Should there be a Jelly Bean Binary wikipedia page, just because you can use jelly beans of two colors to represent binary? How about Othello Binary? Using the two-colored chips from the disc-flipping game for counting in binary?
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The tech industry certainly has competition, but the juicy margins make it much less of an "issue".
Share your terminal as a web application
I think the article states that he did report on it for his newspaper. But MI6 needed proper confirmation, rather than through the lens of a possibly politically biased newspaper - especially when the government was denying the facts themselves.
Feeding the troll, but... many (most?) GGC nodes go in ISP networks, where there are already plenty of other third-party systems (Akamai, Netflix OCA, etc.) and where the traffic is all "hostile" anyway since it's literally the Internet.
It wastes space, and reveals unnecessary information about your server infrastructure.
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Yep, you pretty much explained why the "paid" web never took off the first place and free web dominated the world.

Ironically, in the media world, cable/network, both models of content distribution market existed, there is public station yet there is HBO. Why "HBO" never took place in the web world is a mystery.
Cybersecurity: The glitch in the U.S.-China relationship
> How about a <nojs> </nojs> pair in the primary document disabling any kind of javascript execution in the space between the tags.

But wouldn't folks still be able to inject scripts by just writing `</nojs><script>alert('hi')</script><nojs>`?