skysight-inc/HackerNews huggingface dataset:
This is actually something one of my thesis committee members worked on. http://www.cell.com/abstract/S0092-8674(12)00776-3 In silico whole cell models are an extremely new concept, and his study demonstrated its capabilities for one small bacterium. Needless to say, we have a long way to go before we can make top-down simulations of multicellular organisms, much less one as complex as a human. There are many people trying to generate "good enough" simulations for certain human diseases though, by modeling interactions between genes and biomolecules among a few tissues within the relevant organ system.

With regard to your second question, there are many "omics" assays that can now capture e.g. every mRNA, every protein, etc. at a given timepoint but you have to kill the cells. Fluorescence microscopy can work for "movie-like" time resolution on a live cell but you have to label the cellular elements with stains or antibodies and you can only utilize so many of those simultaneously on a single sample (1-5 is typical).
Distributed block storage v.8 by StorPool
pretty much yeah.
In instance, a lot of new research on statistics is done in R, mainly because is the standard in the industry/academy. If you want to use some new algorith you just readed about on a Journal, it will be implemented almost surely in R.

Julia have been trending for a couple years, and now a lot of researchers publish both R and Julia packages, it seems that in the future most research will be done in Julia.

TL;DR: If you just need basic statistics, interval estimation and alike, then you can use whatever you want, but if you want to use state-of-the-art algorithms. R/Julia are the tools.
Did you see the abacus being used in "stores" or restaurants back then?
John Stossel visited a govt restaurant back then and the waiters were lazy even when the cameras were around.
I do remember reading that many people who fled East Germany wanted to go back. I'm guessing it was mainly adults.
One couple who left Soviet Russia mentioned on a daytime talk show the one thing they did not like about the US was the higher taxes. (Book: For Good and Evil by Charles Adams)
The big reason, performance. On a good day I've seen 5-10x performance improvements over python/numpy for real life code. Of course on bad days I've seen 2x slowdowns, but I'm reasonably confident that within another couple of releases they'll consistently beat python/numpy. Also the Julia syntax is a bit nicer then numpy in my opinion, but that is secondary.

Of course there is both pypy and numba trying to improve the performance on the python side of things.
Measure dry by volume, otherwise you'll have fun making density corrections.

A liter is about a quart and there's 4 cups per quart so figure a cup is about 250 mL volume. Or a half cup would be about 125 mL, etc.

WRT liquid most medical types like to think a teaspoon is about 5 mL and a tablespoon is three teaspoons aka 15 mL.

Good luck with pastry and cake recipes, those require real precision. Everything else, just get the ratios about right and you'll be fine.
Certainly, but that's different topic than the same-day or overnight shipping that you were asking about, no?

Currently those fulfillment centers only use trucks. (I spot checked a few Amazon fulfillment areal photographs on Google Maps.) They would have to be relocated on rail lines, or lines moved to them. There would need to be about 4x more centers, since trucks are about 2x faster. Probably more like 6x more, since trucks and roads go places that trains can't get to because of grade limitations.

Only you know what 'realistic' means to you. We know it's possible to have a rail system that reaches most towns in the US - that's what we had until the automobile. Many of the right-of-ways still exist, but they were also designed for slower, lighter trains than we have now. And for days with more canned and pickled goods that weren't so time sensitive.

Trains don't scale down. Consider a small town grocery store. Currently it will get several different trucks making deliveries - soda, beer, fruit and veg, etc. These make deliveries to many different stores in the area. How does it work if we switch to delivery by rail? Does the train drop off a trailer bundled with all of the daily deliveries? If so, how are thing kept cool that need to be cool? Or are multiple trailers dropped off, and if so, where are they stored and how much room is needed? Does the store need to be next to the tracks?
When I realized that exposing configuration options is not DRY I was able to break away from most frameworks. Within the scope of your own project it's faster to change code, and once you do that you can start to customize it further.
I think the one exception is a cup of coffee, which is 6 oz. And to make it more confusing, if mentioned in a recipe, it could actually mean 8 oz!
MicroPython 1.4.5
Also numpy code looks terribly ugly for numerical computing, when compared with julia (looks like matlab, but the language doesn't suck like matlab.)
Navy need deferred, but F-35 software ‘on the right track’
> Then again he also apparently had himself talked in circles to make his findings fit the labor theory of value.

And what are the record and movie companies imploring us with, when they say we shouldn't copy ("pirate") songs, movies or software? They say that the value of the product came from the work of the artists or programmers, and they deserve to be paid for their efforts. Well what is that but the labor theory of value?

Even corporate America has cast off the subjective theory of value. The labor theory of value was and is correct, but more and more we see things with a new form. A commodity used to be a scarce thing, but nowadays people increasingly create "commodities" which once built are infinitely reproducible for almost no cost, or actually no cost. To where it is not even a commodity any more. So even Marx's theory of the 19th century commodity is upended. Not only that - these new commodities are reusable - from hiphop artists sampling older songs, to developers reusing components. Production is changing, so theories of production must change also. Neither the marginalists nor Marx described what is going on now and will be increasingly so. Although in the sense that Marx posited that production would be radically changed in the future from the 19th century factory system, in that sense he was correct.
Natural Gas Golden Age Fades as Supply Boom Meets Japan Nuclear Rebirth
> which is function chaining within a single runtime

If PowerShells pipelines are merely equivalent to function chaining, then you should have no problem replicating the following very simple pipeline with function chaining in Ruby, Python or JavaScript:

cat log.txt -wait | sls "error"

In case you need an explanation for what it is doing: It continously monitors the log.txt file for new lines, and selects those that contains the substring "error".

But I am curious: Why is it important whether the pipelines could be implemented using function chaining or not? PowerShell is a shell where I interact with the system through commands. Yes - those commands are not the typical Unix executables - but they act as commands within the shell

Is your problem that it is not a Unix shell? You could equally well say that Unix shell pipelines are just processes connected by file descriptors. That is factually correct but does not represent the true utility of pipelines.

PowerShell pipelines are not file descriptors. PowerShell commands do not execute in separate processes. But PowerShell commands are versatile and can be combined in a way analogous to Unix shell pipelines where the output of one command is consumed and acted upon by the next command.

The object of a operating system command line shell is to expose the operating system features to the user of the shell. Why does it matter whether it uses Unix file descriptors. Even if PowerShell pipelines were equivalent to "just" chained functions, why does it matter?

I get the point that you need the .NET runtime to run PowerShell, because it is implemented using .NET. At what point do we consider a runtime part of the operating system. When it is intrinsically distributed with the operating system and cannot be uninstalled?
Which countries have you visited? Any favorite cities/towns?
> At the moment it seems review systems have one level of good, and four varying degrees of poor.

Really well said. And the more tiers there are the worse this gets...

Being less ambiguous about what each rating stands for is such an easy way to resolve this.
Yes, 2 hours of Google on a high salary is expensive but how expensive is it to run businesses where important things are implemented in macros that are barely up to the task? Suppose the macros-patched-together system is really hard to change, breaks easily, or just plain stops working one day and no one knows why...then how much time will be wasted?

Besides, hardware will fail. Windows and other programs eventually end-of-life their support. Organizations that refuse to even consider making changes will eventually feel a lot of pain.

"Poking the bear" is exactly what is needed in most organizations. While it would be crazy to change everything overnight, it's a good idea to periodically look at everything and see what it would take to improve things.
Sean Barrett is a long-time expert and well-known developer in the area of computer graphics.

If you had bothered to read the article, the author attempts to address that concern:

But we can at least understand how we're perceiving the pictures, since they're being displayed as (hopefully) sRGB. They may not reflect reality that well, but we can at least determine the degree to which the numbers in the pictures actually are darkening, and the degree to which it's a perceptual effect we get.
"The dickinson of morality and the Way"?
pg has mentioned the 911 (at least the vintage versions) in his essays about good design, which usually is timeless. While the upcoming 2017 revision will be disappointing to me due to ditching the naturally aspirated engines in all but the track (GT3) cars, here's to another 50 years of 911.

[1] http://www.paulgraham.com/design.html

[2] http://www.paulgraham.com/taste.html
Great news, The Future is here already! These reliable methods for telling computers what to compute are known as Programming Languages.
The death of scripting
We'll just take nationality out of the HN title. Seems safer than trying to adjudicate.
Yeah that was my impression of julia too. Its awesome to use matlab style syntax for matrices and arrays and stuff.
Extensive prior discussion: https://news.ycombinator.com/item?id=10041651
All very true. But what to do about it? The hubris, that is.
This link now takes me to the front page of NYT.
Show HN: A Flask extension that automatically runs pytest in the background
Clouds form over land too.

When warm wet air meets cool air you get clouds. The goal is being able to measure the humidity and temperature of those colliding air masses.
Really? Middle clicks (to open in a new tab) don't work.

Edit: turns out ordinary clicks don't work either, unless I enable some Javascript. I've not worked out which of the 10 or so JS sources need to be whitelisted.

Edit #2: middle clicks on the main page still don't work even with all JS enabled.

Edit for downvoters: Recipes should be the perfect example of the web as documents. We literally have books of recipes going back for 1000s of years - what more of an example of documents could you need? You can enhance these documents with interactivity, sure, but the basic recipes can be presented as plain text and images just fine.

The BBC's cooking website works very well without JS.
Blackboard sticker for your laptop
The NYT's backends (for saving recipes etc) appear to be 503ing right now...
Needs community tagging of recipes. The recipe of the day is vegan and vegetarian, but has neither tag (both of which already exist: http://cooking.nytimes.com/tag/vegan). No doubt this problem exists for other tags and other recipies in the database.

Edit: A cursory search through the BBC's recipe database shows their tags to be notably more thorough, though at times mistaken (butter labeled vegan in http://www.bbc.co.uk/food/recipes/sugar_and_spice_67172) and unfortunately just as immutable at the NYT site.
While trying to nail down the last few bugs in my own chip-8 emulator I consulted other emulators on github (there are tons). Weirdly, some instructions behave slightly differently with every emulator. I found this guide to be the most complete one and hence thought it's worth bringing up. However, I could not find consensus on what "borrow" means for the SUB instructions (8XY5 and 8XY7) - most implementations set the borrow bit even when the two operands are equal.
I bought a cheap set of measuring cups online so I can make US recipes. It was something similar to this:
http://www.amazon.co.uk/Andrew-James-Stainless-Steel-Measuri...
Of course you're right, but then again I believe it was obligatory by law to be employed somewhere.

Those who weren't used to be considered "social parasites" (official terminology, see eg. http://www.zielona-gora.po.gov.pl/index.php?id=36&ida=3790)

Now, whether or how this law was actually enforced is another matter, but at the very least not having a "normal" source of income was frowned upon, so I imagine already standing out as a foreigner you might prefer to keep a straight record.
You can just as easily have these problems with an internal service.

Not for the typical definition of "internal". Typically to reach an internal service you have to be on the internal network. Removal of an ex-user's intranet credentials is usually something IT handles well.
False analogy. You should say "Seems to work fine in Chile". Chile and Venezuela are similar countries; both have an abundant natural resource (copper vs oil).

The one critical difference is property rights- such a thing does not exist in Venezuela. Say what you will about Pinochet...
I used to (almost) exclusively use Python and didn't like that I had to go bath and forth with Cython to make my models fast. Earlier this year I ported some of my code to Julia and feel more productive because of it. I feel like it's easier for me to implement new non-trivial improvements to my models than it was before.

For what it's worth I still stick with Python for computer vision applications. I mostly use Julia for timeseries models (e.g. Semi Markov CRFs) where it's harder to vectorize everything.

If I were restart again I'm not sure if I would suggest going the Julia route. I know there are alternatives like Numba that enable you write efficient code with minimal effort. Overall I like Julia as a language but there are a lot of little issues due to it being a new language.
Nice, just watched all of them. One thing I know for sure now is I need a sharper kitchen knife.
I'm sorry for what we did to the ship, and whoever titled the article wrong.
University of Cambridge Is Getting a Professor of Lego
Not yet, still being translated.
Type-safe authentication in Spock
I remember this being all over the local (Icelandic) news media a couple of years ago. Pretty interesting story: http://www.mbl.is/frettir/erlent/2013/02/28/hefur_thu_sed_ly...
NB: Lauri is now facing three parallel extradition request to the USA as an indirect consequence of failure to comply with a court order to facilitate decryption.

This is not ideal, but will probably fail, hopefully with some precedent set.

[http://theconversation.com/hactivists-arent-terrorists-but-u...]
IBM Manufacturing Systems – Keyboard Assembly (1983) [video]
If you read this and want more like it, the author of the article (Gabriella Coleman) wrote an excellent ethnography on the culture around hackers and free software, which is also available through her site: http://gabriellacoleman.org/Coleman-Coding-Freedom.pdf

The timing might be a little confusing; my understanding is that the book was born out of her dissertation written before 2010, predating the article in the Atlantic, but this book was published after the Atlantic article came out (so it may be even more refined than the article, and certainly more in-depth).

It's longer (on the order of ~250 pages), but it's really great, and one of my favorite examples of Anthropology investigating and thinking about technology and the people that live and breathe it.
I have a better generator at home :

https://drive.google.com/file/d/0B_bsCxOzsxqxOVhyWVdtUU4zUWM...
Wow! So does this mean if I find it, I can claim it as my own, and build an evil layer on it? :) So cool!
HyperLoop: Loopy ideas are fine if you're an entreprenuer
I think you're forgetting the other bad things he mentioned - having to wait in line all day for the chance to get some bread, for example.
7 Hard Truths of Freelancing and How to Overcome Them
The Town That Creep Built
> US police is notorious for its brutality, but are these killings ordered by top officials in chain of command?

https://en.wikipedia.org/wiki/Assassination_of_Fred_Hampton

> If factory workers go on a strike in the US, are police troops sent in to "shoot to kill" them? They did in Poland 30 years ago, eg. https://en.wikipedia.org/wiki/Pacification_of_Wujek

Oh god yes.

https://en.wikipedia.org/wiki/Stockton_cannery_strike_of_193... https://en.wikipedia.org/wiki/St._Petersburg_sanitation_stri... https://en.wikipedia.org/wiki/Auto-Lite_strike#The_.22Battle... https://en.wikipedia.org/wiki/Little_Steel_strike
http://pipeline.corante.com/archives/things_i_wont_work_with...
i have recently read 'the e myth' which i would definitely recommend especially for the business/finance/planning side of things

http://www.amazon.com/The-E-Myth-Revisited-Small-Businesses/...
More like next time be sure to compile without -DTRAUMA.

I knew that block inside #ifdef TRAUMA ... #endif was suspicious.
If you run a real radiosity renderer, you get proper darkening at corners. Here's a Blender rendering with a good radiosity renderer. Note that some inside corners have darkening, and some don't, depending on how they're lighted.[1][2]

Full radiosity renderers are slow. The image is rendered over and over again, each pass using the previous result, with all surfaces now being light sources. Each pass thus shows the result of light being reflected one more time. The corner-darkening effect comes from indirect lighting from the opposite face, an effect which gets smaller as you approach the corner. With some renderers, you can watch the passes, as the image changes from starkly lit to very realistic. Render farms for movie production spend most of their time doing just this.

Game hardware cannot yet do true radiosity in real time, so there are many ways to fake it. Some better than others.

[1] http://s10.photobucket.com/user/RCRuiz/media/3dTest/Illumina...
[2] http://wiki.blender.org/index.php/Doc:2.4/Manual/Lighting/Ra...
Don't forget basically any word used by Javascript programmers

* isomorphic

* functional

* reactive

* responsive
Which is as it should be - that land belongs to all Canadians.

In the UK Queenie gets 15% of crown land to spend on the their lavish lives. I wonder how much rent she takes out of Canadian schools and hospitals. Any idea? Google failed me.
I was thinking about why I liked SNOBOL4/SPITBOL so much. The bizarre syntax and control structures appealed to me for some reason. If you haven't used the language, each statement can succeed or fail. At the end of the statement, you can optionally specify a goto target for success and for failure. There are no higher level control structures that I remember (except for functions), so indenting is not something you (OK, I) normally did. This resulted in very clean looking source code, for some reason. I just remember that impression very strongly. But that doesn't really explain the appeal completely.

The string processing is fantastic -- extremely powerful. I think regexes have a lot of the same power, but I always found SNOBOL4 more readable after the fact, when I had to go back and read and fix my own code. But that's not it either.

I think the main reason I liked SNOBOL4 so much was that it was the first dynamic language I used. Values have types, variables do not. That was a big revelation. I don't think I actually exploited it very often, but it was a cool new idea. And the absence of type declarations also contributed to the sense that the code looked clean. Automatic memory management was also very nice. I had spent a lot of time dealing with memory management in C. I must have in Pascal also. And I really don't remember what Algol-W did for memory management -- a free or delete statement maybe? And of course in FORTRAN, COBOL, and BASIC, there was no dynamically allocated memory at all, so you had to guess high, keep track, etc. Not having to worry about tracking memory was a nice change.
Lightweight Linux Distros – Squeeze Every Drop of Performance Out of Your PC
Human Freedom Index, Sweden, Denmark and Finland are in the top 10 freest countries on earth.

I guess that metric is derived from formal, and institutional freedom or non-freedom promoting policies, but unfortunately, in some respects Sweden is looking increasingly out of place in such a high position on that list.

Anybody who points out that the country's immigration policies are close to destroying the country faces harsh backlash. Anybody just raising questions on the matter really.

Disturbingly, there has been some recent talk of actual formalized anti-freedom measures.

A couple weeks ago there was a stabbing and beheading attack at an IKEA store that killed a mother and son, and now some people in the govt are making noises about limiting freedom of the press because people are discussing it online.

I guess their main concern, according to them is that it is such a shocking, horrific, and in your face illustration of how insane the Swedish government's immigration policies are, that they are concerned people might exercise their democratic rights of guiding the government in what they see as a reasonable direction.

The Press Ombudsman Ola Sigvardsson is concerned that the Swedes are turning to sites run by political motives rather than journalistic ambitions.

Traditional journalism is characterized by a willingness to unconditional search for the truth and make it as good as possible. The other sites are characterized by having a political agenda, said Ola Sigvardsson.

So apparently, now that there is such glaring evidence of the need for political change Sigvardsson is interested in restricting any political discussion that are not inline with his own views.

Freedom of speech and freedom of the press is something that we can not take for granted. Politicians give us the right to print and give our opinion, but requires that we do so in a responsible manner. If we do not do it, maybe freedom curtailed, says Ola Sigvardsson.

https://translate.google.com/translate?sl=sv&tl=en&js=y&prev...
This article[1] has a lot more detail about the ownership and what happened initially to the ship. It seems it actually was lost 3 separate times.

[1]http://www.theglobeandmail.com/news/national/cruise-ship-wit...
Amazing, I've always despised TinyMCE. Great share.
The answer is simple: Web Applications are becoming Applications in the traditional sense of the word -- and Applications have always been complex. Now we're just moving that complexity on to the web.

But that said, the Webpack + React + Flux model is the simplest kind of programming I've done in a very long while.
I've enjoyed digging out older recipes from the 1700's and 1800's from "The Whole Duty of a Woman": https://archive.org/details/wholedutyawoman00unkngoog

Everything from main courses, soups, side dishes, pies, desserts is in it.

I might add that since there are no ovens back then, you have to improvise to the instructions of "hold over fire", and "bake 'till brown", ect.
If we look past the labels and at the actual policies, are there any relevant similarities?

I mean, I don't think Sanders wants to build a fence to keep people from leaving the country, and shoot those who try.