skysight-inc/HackerNews huggingface dataset:
The reason the companies are cherry picking the results is they know this basic problem exists. Only drugs that have evidence of working at stage I and II progress to stage III.

What happens is the drug companies decide at stage III what patients to let into the trial. What they are trying to avoid is anything that will limit the market size once approved. This means they try to skate as close as they can to the effectiveness limit and still get the drug approved.

For example, if they have a new cancer drug that they know only works on cancers with certain mutations, what they will try to do is to test the drug in a broad population of patients including those without the mutation. Since for the approval process it does not really matter how effective the drug is (as long as overall it is statically significant) and that you can only market to the population you tested in, you will want to shove in as many “filler patients" as you think the drug can support. Due to the difficulty of designing large trials they often get the filler number wrong. I don’t condone this activity, but this is the commercial reality.

More fundamentally the pharmaceutical industry is being crushed between two very powerful forces - the cost of developing new drugs continues to get more expensive every year (mostly thanks to regulations), while the real market for each drug shrinks as sub-populations are identified for each disease. Combine this with a refusal of society and insurance companies to pay ever increasing drug prices and the outlook for the industry is not great.
Made it to the top 300 (5%), so I'm satisfied with that. I think I'll improve my application and apply to the winter batch.
> I find the other comments full of praise tarnished by their elision of this crucial detail.

I see no comments below where that crucial detail was relevant to mention, only a number of a comments that express that they found the post interesting and enlightening?
It's all just a ruse to create excitement for yc and no one was in fact invited to interview.
You too, mate!

See ya.
It's annoying how many features and patterns are out of reach if you're targeting Windows.
Isn't that mostly an artifact of deeply nested callbacks? With promises, generators, and what not I've been seeing a lot of new Javascript going back to 4. Is there a pragmatic reason for 2 going forward? I realize it's mostly trivial but I have a much easier time visually parsing 4 vs 2. I also sort've appreciate that it pressures me to reduce indentation.
The size at the speed it did.
Thats not a solution if you have VC money backing you.
If anyone would like to be "radicalized" in a slightly different political direction, I would suggest visiting the real Bethlehem. Then try to reconcile the experience of the people living there with the politics of writers for the New Yorker (on both US and Israeli politics).
I'm curious - I keep getting downvoted whenever I criticise Ashley Madison on the grounds of morality. Why is this?

This isn't a whinge about downvoting (if I didn't want to get downvoted I wouldn't keep posting about A-M), but a genuine inquiry into the reasons.

Is it that people see discussions of morality as off-topic for HN? Do people disagree with my moral judgement of A-M? Or disagree with moral judgement in general?
Early Notes on the Ashley Madison Hack
This is pretty close to the same as Donald Sterling's opinion on black people, and outed gay Republicans who voted against gay equality. Even if the outing was unethical, you can't un-pull the trigger on this being public knowledge, and people become responsible for their own shitty behavior that previously was concealed. Sucks to be them.

And marital infidelity is unethical even if it isn't illegal. It's pretty FUCKING SHITTY to lie to your SO, sometimes for YEARS, exposing them to disease and finally ridicule and humiliation, and their own right to make informed choices about their precious time and trust they invest in a person. It is selfish and rotten and deprives the other person of agency.

edit: on this account I have complained about Internet mob culture multiple times. I was hoping that people would recognize that I was pointing out the hypocrisy of people on this who don't care when it happens to people who do things they personally hate, but I was way too subtle. Resharing this data is a shitty thing to do, but it will happen again and who decides at that point that it's still shitty entirely depends on who is being exposed.
Great comment.

I have also noticed the really strange response from what feels like (anecdotally, I admit) EVERYONE being ecstatic that not only did this leak happen, but that Ashley Madison's users are "getting what's coming to them".

The comparison to fighting against a terrorism-inspired surveillance state was great.
In small companies that are truly solving hard problems, having a CEO who could legitimately do everyone's job points to a hiring failure. In a less ambitious company, having a CEO who could legitimately do everyone's job probably means that the CEO is under-employed.

It is far more common for CEOs to think they can do everyone else's job than for that to actually be the case.
Don't have the leverage or don't have the luck?

Should founders just take less investment if their initial product isn't wildly popular? Tho burning VC money to do market exploration (and failing) doesn't sound too bad (isn't that what it's for? :)
> Windows doesn't have standard directories where libraries live.

Visual Studio certainly does:

Microsoft Visual Studio 11.0\VC\include

Many people argue don't put libraries there - well then you are back to the original problem. Just as long as you don't overwrite a provided library - there are no issues. And if you do overwrite it - you get a rolled up newspaper and start beating the person who overwrote it.
Hi Jordi - I'm sure you're right. You have an amazing resume. Please help us make ND4J/ND4S better. https://github.com/deeplearning4j/nd4j

Nasa JPL is using the framework for climatic modeling, so maybe we can help save the planet together. :)

One response I would have to both your comment and @alephone's rewording, which is perfectly correct, is that they are incomprehensible to most people. So the question is: How do you bridge the gap to make non-mathematicians understand?

The other would be: It's hard to talk about math. There's always slippage when you try to speak in an everyday way about technical things. I'm not sure how to get around that. Too much precision, in this case, undoes the goal of reaching another audience.
Dreamless and The Root 42 felt sort of like a gateway to a future part of the internet.
MIT researchers have developed a camera that will never overexpose an image
Man. my dream is to work for ableton
He had an incredible amount of early traction. For every startup/VC dyad, there's going to be a power imbalance. Either the founder(s) and their company are in high demand (rare), or the VC is (typical).

The side that has the leverage is going to get the best terms. Normally that's the VC. (Liquidation preference, your first born, board seats, etc.)
"Javascript integration is very and tedious."

Even though this doesn't make grammatical sense and missing a word, somehow I understand exactly what it means.
You may want to step back, take a deep breath, and read this from the point of view a potential user of your software and see how it might be an attempt to Davidson the discussion, keeping the report of a bug quiet? It certainly doesn't give me the impression of transparency.
I've tried freeBSD in a Raspberry Pi 1, but I couldn't get any binaries precompiled for ARM :(. I would like to have an easy way to cross-compile ports from my main machine.
I'm pretty sure Windows 7 compatibility mode just makes it so that when a program asks "What version of Windows am I running on?" the system will lie and say "Windows 7." The rest of the compatibility comes from shims written to patch popular and broken applications that incorrectly used Windows APIs in incorrect ways or expected different results from specific calls. Patching broken DRM is beyond what the backwards compatibility can do. SecureROM for instance had a low-level DLL in system32 and games that were "secured" with that DRM used it to take advantage of the system. I read this as that Microsoft isn't providing a way to install that DLL anymore and it would potentially open up an attack vector if they allowed it.
Not only that, why do I need an Android or iOS device? Are we too hip for web configuration pages now?
Getting hungry happens naturally, so does getting sick. Restaurants and healthcare companies are needed to address each need. The incentives are the same.
Previously: https://news.ycombinator.com/item?id=10066432
How do you know it's a good indicator?

One way is to note whether or not the response to the report dismisses it or hand-waves it away. Another response is to neglect the report for 18 months with no reply.

The tests that aphyr conducts are brutal, which you can see by casual inspection of his Call Me Maybe site or his talks. If the response of a software team tries to divert his attention or your attention from the issue, it does not leave a good impression.
I am selling JETPM.com if you are interested.
Because 17.5% of the World's population are Indian?
https://www.google.com/?gws_rd=ssl#q=indian+population+perce...
Why Soylent is a dangerous cult
Browser-friendly enhanced inheritance&mixin with node and coffee supports
Our ancestors will be a bit ripe by then. Did you mean "descendants"?
Zuck also had attracted a talented initial team, so he was able to ride the growth and curtail competition along the way.
And hidden in the middle of the post is:

Be the integrator – When Larry Page took over as CEO of Google, he spent a huge amount of his time forcing every product group to get to a common user profile and sharing paradigm. Why? Because he had to. It would never have happened without the CEO making it happen. It was nobody else’s top priority.

This is a good example where a strong leader can push the entire company in (what I think even Google would now admit was) the wrong direction, and because they are so powerful, the core products can suffer.
A New Elucidation of Colours (1809)
> So why do you feel the need to over-ride your product managers on
> product direction, feature set, user acquisition plans, retention
> strategy, etc?

As long as the CEO isn't micro-managing, why wouldn't they intervene on these topics if the product managers are going in a direction the CEO doesn't want to take the company just yet? The CEO's job is to set the strategy and vision; the manager's job is to execute. If you've hired competent managers, how they execute is up to them. What and why they execute is the responsibility of the CEO and, if the managers are off-course, the CEO must sometimes override them to line things back up with the vision and strategy.
Don't have the leverage or don't have the luck?

Yes.

I'd love to see more nascent startups follow the GitHub path, and seek product-market fit before attracting investment.

Aaron puts on his speculation hat

GitHub didn't need VC funding. They were incredibly profitable from selling their enterprise product, and took funding because one or more of the following were true:

1. The founders wanted liquidity. Like, buying a Gulfstream or three liquidity.

2. The founders were getting bored and wanted to put the 'fuck you, we IPO'd' notch in their collective belt.

3. Early employees with equity were getting restless about their lack of liquidity and threatening to quit unless they got theirs.
Plague Warning Closes Campground in Yosemite
Niche are ill defined. https://xkcd.com/1095/

We are not in the food business, the drink business, the ...

We sell organic locally sourced non fat _ between 6th and ninth street.
I wonder if Robert Virding is just happy to implement another language on Erlang after his efforts on LFE (Lisp Flavored Erlang), or is it going to be a complete, and very usable Lua implementation?
So the Lua implementation is written in Erlang, no need for a Windows .dll or Linux .so?
Very cool. He's a true language nut :)
It's really not clear how or why this is related to IoT. Furthermore, I'm not sure why anyone would wish to use Excel for API testing...what am I missing here?
Disk throwing has been a standard demo/copy party event since the dinosaurs roamed the earth (at least in Finland). I remember there being a disk throwing compo at Assembly '92.
Yelp Official Blog: How Many Stars Would You Give the TSA?
Really don't think you handled this one well m8.
I meant "... beginners and students in addition to experienced people." The posting I replied to seemed to think the book is not for beginners.

I seem to have presumed carry over of a quantifier or range that wasn't clear :)
Ether Crawler – A dungeon crawler and challenge market based on Ethereum
The yellow Google Search Appliance for enterprises is about a decade old. You can still buy them today.

The Nexus One was branded Google. I wouldn't say it's supported by Google anymore because it doesn't receive firmware updates. Google first released it in early 2010.

The Chromebook CR-48 was first released in December 2010, but it wasn't a Google product (unbranded). It still receives software updates today.

BTW the new router isn't a Google product. TP-Link makes it. Google just controls the software, the way Microsoft updates Windows on third-party PCs.
Vim Splits – Move Faster and More Naturally
And, to expand on that, applying for my EB.
The Ashley Madison Database Was Leaked
Why Security Is Every Developer's Responsibility, and How to Approach It
While I agree with you that we are quite different to mice, as far as I know we can’t cure cancer in mice. What we can cure is artificial cancers (i.e those injected into mice), but I know of no study where anyone has tried and succeed curing mouse cancer that replicates human cancer (i.e. let the mice age and develop cancer naturally then treat).

If anyone know of a natural cancer cure study in mice or rats that has been published please get in contact with me (or post here) as I have been looking for one for years.
The Latest on Trump's Enemies List: Facebook's Mark Zuckerberg
I'm not arguing about too many features and you know it.

Complexity and subtleties in a large language can make it difficult to write correct software.
Test and Keep Nespresso Machine Email Scam
On the other hand you really can get severe burns from the filling of a microwaved jelly donut even if the dough part is cool enough to hold. It's true the microwaves don't heat "from the inside out", but it's also true microwaves heat some materials dramatically better than others.
That solves it, then! Everybody should be required to ride motorcycles and lane splitting should be legal everywhere. Best of both worlds!
OK, now tell whose technique is more likely to lead to TeX or Google Brain: Knuth's Literate Programming, or McIlroy's "everything worth doing is already a Unix built-in"?
> Right now, I feel I could do maybe 15 peoples jobs.

I don't know you, so I'm not sure, but in my experience you are wrong. I understand where you came from, being a co-founder myself I know at the beginning you have to do the jobs of 15 or more people so you still believe you are as good as them.

But there are two problems:

- You should hire someone that is better than you. Even if you are the best in your field, you should hire someone that could possibly replace you.

- In almost every non menial job, you need to keep your skills updated. You cannot keep up with 15 different jobs and still run a company with 15 people. So after few months you are no more as good as them.

Be aware, you should understand the job of the people you manage. It is ok to ask them why they made some choice, it is ok to challenge them in a respectful way. But they probably know better. It is not just a morale problem, it is a specific problem.

When you become a manager, your task is no more doing their jobs. Your task is to help them become better at doing their jobs. (The next step is to become a leader, where you simply inspire). I saw a lot of managers at different levels (startup CEOs, mid-level manager) failing because they believe they are better at their jobs than their employees.
Nice to see at least some of these are building things which aren't just smartphone apps solving first-world problems.
For the usual reason: users flagged it. Also, it's a duplicate.
Someone is sending fake emails pretending to be YC
The shell version completely fails on Unicode or even Latin ASCII.
Apple //e graphics were weird from what I remember.

Highres (hgr) 7 colors though 2 whites, 2 blacks purple, green, blue and orange. Certain colors next to each other caused weirdness I think thats why 2 black/white colors.

You could dump the video memory to disk though and load it back. Kind of like a modern screenshot with no compression. the disks couldn't hold a lot of images though made young me frustrated trying to make a graphical adventure. I did a maze game with the 16 color low res graphics..

You could directly manipulate the graphics with the poke command (push values into memory).

"call 62454" inexplicable changed the whole screen to the current color. You could have fun with a loop though the 7 colors.

good times
Peter Thiel – Stanford CS-183B Lecture – Competition Is for Losers
https://twitter.com/ycombinator/status/633842017022271488
Exactly. I know of no mouse study that actually tries to replicate what we want to do in humans.

In regards looking for a cure for cancer we are like the drunk who lost their keys in the dark alleyway, but who is searching around the street lamp since the light is better. Until we actually start doing the right studies we will really struggle getting anywhere.
Yeah, it used to be the case that you had to create ImageData from a previously existing Canvas

The ImageData Constructor got support in Chrome 43 and FireFox 29.
Is there a word for things that only other people can be? The one that always comes to mind is "tourist".
Being edgy and cool doesn't make tech companies any less exploitative
Exploiting kids as subjects does sound repulsive (although using them as subjects with parents consent is perfectly ok for scientific purposes, e.g. see Alison Gopnik's fantastic work and her TED talk: http://www.ted.com/talks/alison_gopnik_what_do_babies_think?...). My suggestion was rather to use this group, which would be tiny as you point out, as a simple "sounding board", e.g. to develop new ways of teaching young children programming. Another way would be to get their ideas and keep them in the loop for development of new products targeting kids. Toy companies, such as Lego, routinely employ kids to test new toys but I think very few involve them in the creation phase.
Me too, and I love this era.
I call b.s on: "and couldn't be happier."

Individual humans may have other things that motivate.
Information is always measurable in bits. I am not sure that all signals are always measurable in bits.

Prior to the discovery of the Rosetta Stone, Egyptian hieroglyphics were signals without information - no decoder existed. Ironically, the number of bits needed to encode all Egyptian hieroglyphics would have been calculable ( presumably the alphabet was finite ) , but they could not have been decoded.
This is well produced and fun to watch. Great memories, thank you.
It's a good article on a fascinating writer, but I think we have to count it as a dupe: https://news.ycombinator.com/item?id=10061848.
Actually most of them worked in humans too since they are stage III trials and drugs only progress to stage III if they have shown some sign of effectiveness in stage I and II. Pharmaceutical companies just don’t spend 10's of million of dollars on stage III trials unless they have evidence that the drug works.
Vim client-server
Maybe in the US. In the UK its the default on any router from the biggest telco, and the biggest cable provider are turning it on imminently. I've yet to hear anyone complain about it.
I feel compelled to respond to his (by no means unique) claims about teaching and tenure.

"Doing a good job with teaching is perversely seen as a cardinal sin in some departments."

Name one. Give some examples. If you're going to play this game of taking the obviously popular side of "ethical enough to do your job" then you need to be more forthcoming. The part about teaching is self-promotional BS.

Perhaps in the very best departments, where they have so much money that good researchers rarely teach, tenure decisions are not based solely on research. There are very few institutions for which that is true though. You don't have to be a star teacher, but claiming that anyone not entertaining the students at a level to win university-wide teaching awards means they are "Torturing a captive audience every semester with soul-sapping lectures is criminal theft of tuition" is quite a jump.

This is one of the most arrogant blog posts I've ever read. He did what most faculty members do to get tenure. He did research, teaching, and service at an acceptable level.
The Technical Treadmill of Software Development
Previously: https://news.ycombinator.com/item?id=10076731
MozPromise: A Better Tool for Asynchronous C++
Ask HN: Y U No Comment If U No Like?
Throw-away account obviously.

Following dang's advice, I've resubmitted things a few times that got a lot of interest on other sites (let's say, Slashdot and Reddit, why not?). I'm lucky if any one of them ever got a single upvote.

Nobody has suggested, "Hey, we don't like this material," so I have no indication that there's a lack of interest in my submissions. I've never been flag-killed, and my account has >1000 karma from comments, so I like to think I'm not too abrasive to the community.

So it's starting to frustrate me and baffle me when they continue to get no interest from the community, but no one tells me what they dislike about it.

I'm not going to out myself and name specifics (please don't ask), I just want to ask in general why HN is like this.
Even if you had people agree on standards, there would be misunderstandings and people would deviate. Have you ever worked with standards for any sort of protocol/process/language? Try it some time.
It's a different directory for every version of Visual Studio (and obviously mingw doesn't use it), ergo it's not a standard directory like /usr/include

His point is that it's arguably simpler to tell people to copy a single source file to their project's source tree, than it is to help them find the include dir for whatever compiler they happen to be using. And that it's probably easier to have to manually update this file when the library is patched, than it is to coordinate manual library updates across an entire team without the use of a package manager.
Rip and Convert DVD to iPod Classic
I can think of a lot of things other than Confederate flags, I was making a symbolic argument against your misuse of the word bikeshed.

Slavery is a bad practice and I would definitely not work with someone who felt otherwise, but other than that, your argument is just worthless escapism. Have fun talking to HR in the future.
If in that email my status of "decline" is different, I would like to accept as true. But how they obtained the list of emails of who signed up for the program?
Lesser-Known Google Projects
Thanks for the response. It's good to hear that you're thinking about local access.

I realize that the node module thing is just one example of a feature that relies on hosting, but fwiw I wouldn't mind having to manually maintain a local package.json and node_modules folder for whatever libraries I want to be able to use in the environment.
Owlet (Smartphone infant breathing monitor) raises Series A led by Formation 8