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abstract: Atomically thin transition metal dichalcogenides (TMDs) are of interest for next generation electronics and optoelectronics. Here, we demonstrate device ready synthetic tungsten diselenide (WSe2) via metal organic chemical vapor deposition and provide key insights into the phenomena that control the properties of large area, epitaxial TMDs. When epitaxy is achieved, the sapphire surface reconstructs, leading to strong 2D/3D (i.e. TMD/substrate) interactions that impact carrier transport. Furthermore, we demonstrate that substrate step edges are a major source of carrier doping and scattering. Even with 2D/3D coupling, transistors utilizing transfer free epitaxial WSe2/sapphire exhibit ambipolar behavior with excellent on/off ratios ~107) high current density (1 10 mA*mm 1) and good field effect transistor mobility ~30 cm2*V 1*s 1) at room temperature. This work establishes that realization of electronic grade epitaxial TMDs must consider the impact of the TMD precursors, substrate, and the 2D/3D interface as leading factors in electronic performance.
author_names: Yu-Chuan Lin

B Jariwala

Brian M Bersch

Ke Xu

Yifan Nie

Baoming Wang

Sarah M Eichfeld

Xiaotian Zhang

Tanushree H Choudhury

Yi Pan

Rafik Addou

Christopher M Smyth

Jun Li

Kehao Zhang

M Aman Haque

Stefan Folsch

Randall M Feenstra

Robert M Wallace

Kyeongjae Cho

Susan K Fullerton-Shirey

Joan M Redwing

Joshua A Robinson
title: Realizing Large Scale, Electronic Grade Two Dimensional Semiconductors.
venue: ACS nano
year: 2018

abstract: The effects of radiation and Hall current on an unsteady magnetohydrodynamic free convective flow in a vertical channel filled with a porous medium have been studied. We consider an incompressible viscous and electrically conducting incompressible viscous second grade fluid bounded by a loosely packed porous medium. The fluid is driven by an oscillating pressure gradient parallel to the channel plates, and the entire flow field is subjected to a uniform inclined magnetic field of strength Ho inclined at an angle of inclination a with the normal to the boundaries in the transverse xy plane. The temperature of one of the plates varies periodically, and the temperature difference of the plates is high enough to induce the radiative heat transfer. The effects of various parameters on the velocity profiles, the skin friction, temperature field, rate of heat transfer in terms of their amplitude, and phase angles are shown graphically.
author_names: M VeeraKrishna

G V Subba Reddy

Ali J Chamkha
title: Hall effects on unsteady MHD oscillatory free convective flow of second grade fluid through porous medium between two vertical plates
year: 2018

abstract: Completeness of mast cell tumour (MCT) excision is determined by assessment of histologically tumour free margins (HTFM) The HTFM width necessary to prevent local recurrence (LR) recognized as histologic safety margin (HSM) in human oncology, has not been defined. We hypothesized that HTFM width would correlate with risk for LR and high grade tumours would require wider HTFM than low grade tumours. Records of dogs with completely excised MCTs were included. Signalment, two tier tumour grade, tumour size, HTFM width, recurrence and therapy data was collected. High grade (n 39) tumours were more likely to recur than low grade (n 51) tumours (35.9% versus 3.9% P 0.0001, with no association between HTFM width and LR. Twenty nine percent of low grade tumours had HTFM less than 3 mm; none recurred. Narrow =3 mm) histologic margins are likely adequate to prevent LR of low grade tumours. High grade tumours have significant risk of LR regardless of HTFM width.
author_names: Lauren Donnelly

Christopher Mullin

Jody A Balko

Michael H Goldschmidt

E L Krick

C Hume

D C Brown

Karin U Sorenmo
title: Evaluation of histological grade and histologically tumour free margins as predictors of local recurrence in completely excised canine mast cell tumours.
venue: Veterinary and comparative oncology
year: 2015

abstract: PURPOSE Surgery is curative therapy for pediatric low grade gliomas (LGGs) in areas of the brain amenable to complete resection. However, LGGs located in areas where complete resection is not possible can threaten both function and life. The purpose of this study was to compare two chemotherapy regimens for LGGs in children younger than age 10 years for whom radiotherapy was felt by the practitioner to pose a high risk of neurodevelopmental injury. PATIENTS AND METHODS Previously untreated children younger than age 10 years with progressive or residual LGGs were eligible. Children were randomly assigned to receive carboplatin and vincristine (CV) or thioguanine, procarbazine, lomustine, and vincristine (TPCV) Children with neurofibromatosis are reported separately. Results Of 274 randomly assigned patients who met eligibility requirements, 137 received CV and 137 received TPCV. The 5 year event free survival (EFS) and overall survival (OS) rates for all eligible patients were 45% 3.2% and 86% 2.2% respectively. The 5 year EFS rates were 39% 4% for CV and 52% 5% for TPCV (stratified log rank test P .10; cure model analysis P .007) On multivariate analysis, factors independently predictive of worse EFS and OS were younger age and tumor size greater than 3 cm(2) Tumor location in the thalamus was also associated with poor OS. CONCLUSION The difference in EFS between the regimens did not reach significance on the basis of the stratified log rank test. The 5 year EFS was higher for TPCV on the basis of the cure model analysis. Differences in toxicity may influence physician choice of regimens.
author_names: Joann L Ater

Tianni Zhou

Emi Holmes

Claire M Mazewski

Timothy N Booth

David R Freyer

K H Lazarus

Roger J Packer

M Prados

Richard Sposto

Gilbert Vezina

Jeffrey H Wisoff

Ian F Pollack
title: Randomized study of two chemotherapy regimens for treatment of low grade glioma in young children: a report from the Children's Oncology Group.
venue: Journal of clinical oncology official journal of the American Society of Clinical Oncology
year: 2012

abstract: Abstract The aim of this work is to establish a two dimensional (2D) and quasi three dimensional (quasi 3D) shear deformation theories, which can model the free vibration of FG plates resting on elastic foundations using a new shear strain shape function. The proposed theories have a novel displacement field which includes undetermined integral terms and contains fewer unknowns with taking into account the effects of both transverse shear and thickness stretching. The mechanical properties of the plates are assumed to vary through the thickness according to a power law distribution in terms of the volume fractions of the constituents. The elastic foundation parameters are introduced in the present formulation by following the Pasternak (two parameters) mathematical model. Hamilton's principle is employed to determine the equations of motion. The closed form solutions are derived by using Navier's method and then fundamental frequencies are obtained by solving the results of eigenvalue problems. The efficiency of the proposed theory is ascertained by comparing the results of numerical examples with the different 2D, 3D and quasi 3D solutions found in literature.
author_names: Fatima Zohra Zaoui

D Ouinas

Abdelouahed Tounsi
title: New 2D and quasi 3D shear deformation theories for free vibration of functionally graded plates on elastic foundations
venue: Composites Part B: Engineering
year: 2019

abstract: Abstract In this study, bending, free vibration, and buckling response of functionally graded porous micro plates are investigated using the classical and first order shear deformation plate theories. The Navier solution technique is utilized to obtain analytical solutions to simply supported rectangular plates. A power law distribution is used to model the variation of two material constituents through the plate thickness. Three different porosity distributions are considered and assumed to take forms of cosine functions. The microstructure dependent size effects are captured using the modified couple stress theory. Numerical results of bending, free vibration, and buckling are presented to determined the effects of constituent material variation, microstructure dependent size effects, and porosity distributions on the mechanical response of functionally graded porous micro plates.
author_names: Jinseok Kim

Krzysztof Kamil Zur

J N Reddy
title: Bending, free vibration, and buckling of modified couples stress based functionally graded porous micro plates
venue: Composite Structures
year: 2019

abstract: OBJECTIVE An integrated analysis was undertaken to characterize the antitumor activity and safety profile of the oral poly(ADP ribose) polymerase inhibitor rucaparib in patients with relapsed high grade ovarian carcinoma (HGOC) METHODS Eligible patients from Study 10 (NCT01482715) and ARIEL2 (NCT01891344) who received a starting dose of oral rucaparib 600mg twice daily (BID) with or without food were included in these analyses. The integrated efficacy population included patients with HGOC and a deleterious germline or somatic BRCA1 or BRCA2 (BRCA1/2) mutation who received at least two prior chemotherapies and were sensitive, resistant, or refractory to platinum based chemotherapy. The primary endpoint was investigator assessed confirmed objective response rate (ORR) Secondary endpoints included duration of response (DOR) and progression free survival (PFS) The integrated safety population included patients with HGOC who received at least one dose of rucaparib 600mg BID, irrespective of BRCA1/2 mutation status and prior treatments. RESULTS In the efficacy population (n=106) ORR was 53.8% (95% confidence interval [CI] 43.8 63.5) 8.5% and 45.3% of patients achieved complete and partial responses, respectively. Median DOR was 9.2months (95% CI, 6.6 11.6) In the safety population (n=377) the most frequent treatment emergent adverse events (AEs) were nausea, asthenia/fatigue, vomiting, and anemia/hemoglobin decreased. The most common grade =3 treatment emergent AE was anemia/hemoglobin decreased. Treatment emergent AEs led to treatment interruption, dose reduction, and treatment discontinuation in 58.6% 45.9% and 9.8% of patients, respectively. No treatment related deaths occurred. CONCLUSIONS Rucaparib has antitumor activity in advanced BRCA1/2 mutated HGOC and a manageable safety profile.
author_names: Amit M Oza

Anna V Tinker

Ana Oaknin

Ronnie Shapira-Frommer

Iain A McNeish

Elizabeth M Swisher

Isabelle Ray-Coquard

Katherine M Bell-McGuinn

Robert L Coleman

David M O'Malley

Alexandra Leary

Lee-may Chen

Diane Provencher

Ling Ma

James D Brenton

Gottfried E Konecny

Cesar M Castro

Heidi Giordano

Lara Maloney

Sandra M Goble

Kevin K Lin

James X Sun

Mitch Raponi

Lindsey Rolfe

Rebecca S Kristeleit
title: Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: Integrated analysis of data from Study 10 and ARIEL2.
venue: Gynecologic oncology
year: 2017

abstract: BACKGROUND Less than 50% of all high grade non Hodgkin lymphoma (NHL) patients experience lasting disease free survival. Risk adapted treatment strategies require better tools for prediction of outcome. This investigation aimed to assess the value of positron emission tomography with 2 [18F]fluoro 2 deoxy D glucose (FDG PET) after two to three cycles of chemotherapy for prediction of progression free survival (PFS) and overall survival (OS) PATIENTS AND METHODS One hundred and twenty one patients with high grade NHL underwent FDG PET. The therapy response on FDG PET was correlated to PFS and OS using Kaplan Meier survival analysis. Cox regression analyses were employed to test for independence of known pretreatment prognostic factors. RESULTS Fifty FDG PET scans were negative, 19 scans showed minimal residual uptake (MRU) and 52 scans were positive. The estimated 5 year PFS was 88.8% for the PET negative group, 59.3% for the MRU group, and 16.2% for the PET positive group. Kaplan Meier analyses showed strong associations between FDG PET results and PFS (P <0.0001) and OS (P <0.01) Early interim FDG PET was independent of the other prognostic factors. CONCLUSIONS Early interim FDG PET is an accurate and independent predictor of PFS and OS. An early assessment of chemotherapy response with FDG PET could provide the basis for selection of patients for alternative therapeutic strategies.
author_names: N George Mikhaeel

Martin Hutchings

Paul A Fields

Michael O'Doherty

A R Timothy
title: FDG PET after two to three cycles of chemotherapy predicts progression free and overall survival in high grade non Hodgkin lymphoma.
venue: Annals of oncology official journal of the European Society for Medical Oncology
year: 2005

abstract: Purpose The purpose of this study was to examine outcomes associated with hormonal maintenance therapy (HMT) compared with routine observation (OBS) after primary cytoreductive surgery and platinum based chemotherapy in women with stage II to IV low grade serous carcinoma of the ovary or peritoneum. Patients and Methods Eligibility criteria for patients from our database were: treatment with primary surgery followed by platinum based chemotherapy, stage II to IV disease, at least 2 years of follow up for patients who had not experienced recurrence, and adequate clinical information. The two groups were compared for progression free survival (PFS) and overall survival, and a multivariable Cox regression analysis was performed. Subset analyses for patients who were disease free or had persistent disease were also performed. Results Between 1981 and 2013, 203 eligible patients 133 who underwent OBS and 70 who received HMT were seen at our institution. Median PFS for patients who underwent OBS was 26.4 months, compared with 64.9 months for those who received HMT P .001) No statistically significant difference in overall survival was observed between the two groups (102.7 v 115.7 months, respectively) For subgroups of women who were disease free or had persistent disease, median PFS was superior for those who received HMT (81.1 v 30.0 months; P .001 and 38.1 v 15.2 months; P .001, respectively) Women who received HMT had a significantly lower risk of disease progression compared with those who underwent OBS (hazard ratio, 0.44; 95% CI, 0.31 to 0.64; P .001) Conclusion Women with stage II to IV low grade serous carcinoma who received HMT after primary treatment had significantly longer PFS compared with women who underwent OBS. These findings warrant further investigation using a prospective trial design.
author_names: David M Gershenson

Diane C Bodurka

Robert L Coleman

Karen H Lu

Anais Malpica

Charlotte C Sun
title: Hormonal Maintenance Therapy for Women With Low Grade Serous Cancer of the Ovary or Peritoneum.
venue: Journal of clinical oncology official journal of the American Society of Clinical Oncology
year: 2017

abstract: This paper presents a free vibration analysis of functionally graded materials nano plate resting on Winkler Pasternak elastic foundations based on two variable refined plate theories including the porosities effect. The small scale effects are introduced using the nonlocal elasticity theory with a new shear deformation function. The governing equations are obtained through the Hamilton's principle. The effect of material property, porosities, various boundary conditions and elastic foundation stiffnesses on free vibration functionally graded materials nanoplate are also presented and discussed in detail. The present solutions are compared with those obtained by other researchers. The results are in a good agreement with those in the literature.
author_names: I Mechab

Belaid Mechab

Samir Benaissa

Boualem Serier

Bachir Bachir Bouiadjra
title: Free vibration analysis of FGM nanoplate with porosities resting on Winkler Pasternak elastic foundations based on two variable refined plate theories
year: 2016