Search query: indole schiff base

Related papers:

abstract: Objective: A set of different nanocomposite hybrid materials of Sr0.5 Y0.1 Cu0.3 has been synthesized through co precipitation synthetic method using Cetyl Trimethyl Ammonium Bromide (CTAB) and Tri ethyl amine (TEA) as surfactants. The different derivatives of indole Schiff base compounds (5a 5e) were doped to the nanocomposites in molar ratio of 1 2% The entire hybrid material isolated by forming gelatinous network and calcinated. The hybrid nanomaterials were investigated for their semiconductor and dielectric properties. Method: Nanocompositional hybrid materials were prepared by co precipitation method with the composition of Sr0.5 Y0.1 Cu0.3 with doping of indole Schiff base derivative (ISB) of molar ratio 1 2% and the reduction is done using surface reduction methods gelated precipitate of hybrid nanomaterials were calcinated, characterized by XRD, FT IR, UV Vis and SEM spectroscopic techniques. The semiconductor and dielectric properties of pelletalized samples were measured with respect to various temperatures and frequency. The precursor material used for the synthesis is strontium carbonate, yttrium oxide and cuprous chloride which are reduced in presence of CTAB and urea. After isolating the hybrid materials ISB derivatives (5a 5e) were doped and the aqueous mixture of bluish reddish precipitate was filtered, washed with ethyl alcohol and octanol mixture to remove any impurities present with the precipitate, dried at 50 120 degC, heat treated at 650 750 degC and obtained pure nanocomposite. Findings: Initial spectroscopic studies showed that grain size of copper was 20 30 nm in diameter. XRD pattern demonstrated the formation of trigonal copper and dopant addition considerably affects the crystal structure. The dielectric constant were measured and compared with undoped hybrid material. The band alignment and band gap obtained from the ISB material was further felicitating the fissile ejection of the electrons and ensuring the semiconductor properties of the materials.
author_names: Vinayak Adimule

P Vageesha

Gangadhar B Bagihalli

Debdas Bowmik

H J Adarsha
title: Synthesis, Characterization of Hybrid Nanomaterials of Strontium, Yttrium, Copper Doped with Indole Schiff Base Derivatives Possessing Dielectric and Semiconductor Properties
year: 2019

abstract: Breast cancer is the most frequently diagnosed cancer among women worldwide. Recently, increasing attention has been paid to the anticancer effects of transition metal complexes of indole Schiff bases. b diiminato ManganeseIII complex has shown promising cell cycle arrest and apoptosis induction against MCF 7 and MDA MB 231 breast cancer cells. In this study, time and dose dependent inhibitory activity were evaluated using MTT assay after 48 h and 72 h exposure time. In addition, median effect analysis was conducted according to Chou Talalay method to investigate whether MnIII complex has synergistic effect in combination with chemotherapeutic drugs on inhibiting breast cancer cell growth. The molecular mechanisms underlying its potent antiproliferative effect was determined through bioluminescent caspase 3/7, 8 and 9 activity assays and quantitative expression analysis of cell cycle and apoptosis related genes. Furthermore, safety evaluation of MnIII complex was assessed through the acute oral toxicity test in in vivo model. The MTT assay results revealed that it potently reduced the viability of MCF 7 (IC50 of 0.63 0.07 ug/mL for 48 h and 0.39 0.08 ug/mL for 72 h) and MDA MB 231 (1.17 0.06 ug/mL for 48 h, 1.03 0.15 ug/mL for 72 h) cells in dose and time dependent manner. Combination treatment also enhanced the cytotoxic effects of doxorubicin but not tamoxifen on inhibiting breast cancer cell growth. The involvement of intrinsic and extrinsic pathway in apoptosis induction was exhibited through the increased activity of caspase 9 and caspase 8, respectively, leading to enhanced downstream executioner caspase 3/7 activity in treated MCF 7 and MDA MB 231 cells. In addition, gene expression analysis revealed that MnIII complex exerts its antiproliferative effect via up and down regulation of p21 and cyclin D1, respectively, along with increased expression of Bax/Bcl 2 ratio, TNF a, initiator caspase 8 and 10 and effector caspase 3 in MCF 7 and MDA MB 231 cells. However, the results did not show increased caspase 8 activity in treated MCF 7 cells. Furthermore, in vivo acute oral toxicity test revealed no signs of toxicity and mortality in treated animal models compared to the control group. Collectively, the promising inhibitory effect and molecular and mechanistic evidence of antiproliferative activity of MnIII complex and its safety characterization have demonstrated that it may have therapeutic value in breast cancer treatment worthy of further investigation and development.
author_names: Reyhaneh Farghadani

Maryam Seifaddinipour

Jayakumar Rajarajeswaran

Mahmood Ameen Abdulla

Najihah Mohd Hashim

Si Lay Khaing

Nur'ain Salehen
title: In vivo acute toxicity evaluation and in vitro molecular mechanism study of antiproliferative activity of a novel indole Schiff base b diiminato manganeseIII complex in hormone dependent and triple negative breast cancer cells
venue: PeerJ
year: 2019

abstract: Two novel fluorescence probes based on conjugated Schiff base for the detection of Zn(2+ were developed. Corresponding molecular geometries, orbital energies, electron contributions and absorption properties of the fluorescence probes were calculated at B3LYP/6 31G( by density functional theory. The fluorescence properties of the probes were investigated by UV vis and fluorescence spectrometer. Results indicate that the probes exhibit excellent sensitivity and selectivity for Zn(2+ compared with metal ions examined. For example, the enhancement efficiency of the compound 2 for Zn(2+ is up to 846% The detection limit of the sensor toward Zn(2+ could low to 1.0x10( 7)M. Moreover, mechanisms for the high selectivity and sensitivity of the probes to Zn(2+ were studied.
author_names: Ting Xu

Hongdong Duan

Xingjian Wang

Xia Meng

Juan Bu
title: Fluorescence sensors for Zn(2+ based on conjugated indole Schiff base.
venue: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
year: 2015

abstract: Two new conjugated Schiff bases were prepared by condensation reactions between indole derivatives and o phenylenediamine, respectively. The structures of the synthetic compounds were characterized by IR, 1H NMR, and elemental analysis. And the melting point determination revealed that both compounds have good thermal stability. Their fluorescence measurements indicated that both compounds in solution have excellent performance on fluorescence emission, and the intensity of fluorescence emissions was quenched sharply by adding copper (II) nitrate. And the spectral changes were examined upon addition of various metal ions, such as Cu2+ Cd2+ Co2+ Ni2+ and Zn2+ The results indicated that the fluorescence intensity of two compounds quenched dramatically, and the quenching efficiency of Cu2+ was the highest.
author_names: Juan Bu

Hongdong Duan

Xingjian Wang
title: Fluorescence sensors for Cu2+ based on conjugated indole Schiff base
venue: Research on Chemical Intermediates
year: 2013

abstract: Abstract An efficient triazole Schiff base fluorescent Al3+ probe 4 (2 hydroxybenzylidene) amino) 5 (1H indol 3 yl) 4H 1,2,4 triazole 3 thiol (H2L) was designed and synthesized under microwave irradiation. The structure of fluorescent probe H2L was characterized by spectral data and elemental analysis. The probe H2L displays excellent chemo selectivity towards Al3+ over other metal ions, which can directly inspect with the naked eye under UV lamp. The limit of detection of the probe H2L for Al3+ could reach 29.9 nM. The binding stoichiometry between H2L and Al3+ was determined from the Job's plot to be 1:1, the association constant (Ka) of 9.31 x 104 M 1, and further verified with fluorescence titration, ESI MS and 1H NMR study.
author_names: Zhichuan Shi

Zhigang Zhao
title: Microwave irradiation synthesis of novel indole triazole Schiff base fluorescent probe for Al3+ ion
year: 2019

abstract: Schiff base complexes of N 2 O 2 type derived from indole 3 carboxaldehyde(ind) and amino acids such as glycine(gly) L valine(val) and L tryptophan(try) with Cu(II) Ni(II) Zn(II) Co(II) and Mn(II) were synthesized and characterized by physical and analytical techniques. The complexes are of non electrolytic nature having 1:2 (metal:ligand) ratio. The geometry of the complexes was predicted with the combined data obtained from electronic spectral and magnetic susceptibility measurements. The mode of coordination of the Schiff base ligands with the metal ions is through the carboxylate oxygen and the azomethine nitrogen as confirmed by FT IR spectra. The cyclic voltammogram of the Cu(II)complexes exhibit Cu(II)(r)Cu(I) peak in the cathodic side and the corresponding quasi reversible type peak is obtained in the anodic side. The thermal behavior (TG/DTA) of the synthesized complexes shows that the complexes loose water molecules in the first step followed by decomposition of the ligand, which follows first order kinetics. The SEM analysis reveals the particle size and the morphology of the complexes. The X band EPR spectrum of Cu indgly complex in DMSO solution at 300 and 77 K was recorded. The calculated g tensor values agree with the geometry proposed by the electronic absorption spectral measurements. The M indval complexes were studied for their cleaving ability with calf thymus DNA by gel electrophoresis method. The antibacterial activity of the Schiff base metal complexes was tested in vitro against some common bacteria using ampicillin as control. Antifungal activities were determined using nystatin as control. The results are compared with control; most of the metal chelates exhibited higher biological activities.
author_names: Rusal Raj Francis

Mallanpillai Anathakrishnan Neelakantan
title: Synthesis, Structural Characterization and Biological Studies of Schiff Base Complexes Bearing Indole Moiety
year: 2019

abstract: The invention relates to a nitrobenzaldehyde indole schiff base, a preparation method and application thereof. The schiff base has a structural formula shown as (I) (II) or (III) and a substituent R is NO2. The preparation method comprises steps of: placing a solvent of ethanol in a reactor and adding nitrobenzaldehyde; adding amino indole compound with a same molar amount as the nitrobenzaldehyde; dissolving completely and controlling a temperature at 60 80 DEG C, heating for reflux and reacting for 4 8 h; and evaporating solution in the reactor to obtain a crude product and recrystallizing to obtain a finished product. The product of the invention can effectively inhibit propagation of a plurality of tumor cell strains and has good water solubility.
title: Nitrobenzaldehyde indole schiff base, preparation method and application thereof
year: 2011

abstract: 3 (2 aminophenyl)imino] 1,3 dihydro 2H indol 2one, (Lo) 1,3 phenylenediazanylylidene di (1,3 dihydro 2Hindol 2 one) (Lm) and 1,4 phenylenediazanylylidene di(1,3dihydro 2H indol 2 one) (Lp) were synthesized by the reaction of 1H indole 2,3 dione with benzene 1,2 diamine, benzene 1,3diamine and benzene 1,4 diamine respectively. The reaction of Lo, Lm and Lp with Co(II) and Ni(II) halides gave the corresponding coordination complexes which were characterized by elemental analysis, molar conductance, infrared, GC MS and electronic spectral studies. Docking of the 1Hindole 2,3 diones toward the binding sites of penicillin binding protein and DNA gyrase showed they interacted favourably with the test antibacterial targets at Gs range of 2.51 to 5.48 kcal/mol. In accordance to literature report, coordination of cobalt and nickel to the ligands yielded metal complexes which exhibited improved interaction with the protein targets (at Gs range of 8.70 to 10.20 kcal/mol) In vitro antimicrobial studies against some microorganisms showed that some of the compounds were active against few Gram negative and Gram positive bacteria. The Lo, Lm and Lp had no activity against any of the test microorganisms but the Co(II) and Ni(II) complexes, showed antibacterial activity. The [Co(Lo)2] and [Ni(Lo)2] complexes generated the least antibacterial response. [Co(Lo)2] was ineffective against E. coli 6 and Staphylococcus sciuri subsp sciuri while Bacillus subtilis was resistant to [Ni(Lo)2] which moderately inhibited E. coli 14 (7 mm) Both compounds indicated zero activity against Pseudomonas aeruginosa. The complex that evoked the highest bactericidal activity were [CoLm]Cl2 and [NiLp]Cl2. The antibiogram activity of [CoLm]Cl2 was found between 20 and 30 mm with E. coli 6 displaying greater sensitivity (30 mm) and S. sciuri the least (20 mm) The activity of [NiLp]Cl2 complex indicate that the activity spectrum of the organisms occurred within 29 and 45 mm range; the least Received January 23, 2019 Accepted April 24, 2019 Released April 30, 2019
author_names: Helen O Echekwube

Pius Onyeoziri Ukoha

Oguejiofo Theophilus Ujam

Charles O Nwuche

Jonnie N Asegbeloyin

Akachukwu Ibezim
title: Synthesis and in silico investigation of Schiff base derivatives of 1H indole 2,3 diones and their Co(II) and Ni(II) complexes as antimicrobial agents
year: 2019

abstract: Abstract This research work presents the structural features and biological activities of a novel series of Mn/Fe/Co/Ni/Cu/Zn(II) (indal L his) complexes obtained from indole 3 carboxaldehyde (indal) and L histidine (L his) The prepared compounds were characterized by elemental analysis, molar conductivity, magnetic, IR, UV vis, 1H NMR, mass and ESR spectroscopies, powder XRD and TGA studies. Electronic spectra and magnetic moment data suggest an octahedral geometry for [Mn(II) (indal L his)2(H2O)2] and [Fe(II) (indal L his)2(H2O)2] tetrahedral geometry for [Co(II) (indal L his)2] and [Zn(II) (indal L his)2] and square planar geometry were assigned for [Ni(II) (indal L his)2] and [Cu(II) (indal L his)2] The photocatalytic efficiency was explored for the synthesized compounds. In vitro antimicrobial activity of synthesized compounds was analyzed against some selected Gram positive and Gram negative bacterial and fungal species by disc diffusion technique. The compounds have shown to reveal excellent antibacterial and antifungal activity. Graphical Abstract
author_names: R Reshma

Raphael Selwin Joseyphus

Arish Dasan

Liji John
title: Synthesis and spectral characterization of metal complexes of Schiff base derived from indole 3 carboxaldehyde and L histidine as potent biocides
venue: Journal of Coordination Chemistry
year: 2019

abstract: Two Schiff base derivatives (S1 and S2) containing triphenylamine and indole fluorophores groups have been synthesized via a one pot reaction and utilized as fluorescence turn off sensors towards Fe3+ ions in THF. S1 and S2 demonstrated fluorescence turn off sensing towards Fe3+ ions, via photoinduced electron transfer (PET) The 2 1 stoichiometries of the sensor complexes [S1, S2] Fe3+ were calculated from Job plots based on UV vis absorption titrations. The detection limits (LODs) of [S1, S2] Fe3+ sensor responses were calculated by their standard deviation, linear fitting and from their fluorescence binding isotherms. More importantly, [S1, S2] Fe3+ sensors were found to be active in aqueous media within a wide range of pH values. In addition, biological imaging and membrane permeability demonstrated that S1 could act as a turn off fluorescence chemosensor for Fe3+ in living cells.
author_names: Chengqiang Pan

Wang Kai

Shaomin Ji

Huaqian Wang

Li Zongzhi

Huahong He

Yanping Huo
title: Schiff base derived Fe3+ selective fluorescence turn off chemsensors based on triphenylamine and indole: synthesis, properties and application in living cells
year: 2017