shlokn/autogkb huggingface dataset:
Article: ABCB1 Polymorphism Is Associated with Higher Carbamazepine Clearance in Children
Gene: ABCB1
Variant/haplotype: rs1045642
Drug(s): carbamazepine
Phenotype category: Metabolism/PK
Significant: not stated
Association: Allele A is associated with increased clearance of carbamazepine in children with Epilepsy as compared to allele G.
Notes: Alleles complemented. "Our main finding was that the presence of the ABCB1 1236T-2677T-3435T haplotype was associated with an increased clearance of CBZ in children. " "rs1045642 (3435C>T)"
Article: Potential Role of Patients’ CYP3A-Status in Clozapine Pharmacokinetics
Gene: CYP3A5
Variant/haplotype: CYP3A5*1, CYP3A5*3
Drug(s): clozapine
Phenotype category: Dosage
Significant: yes
Association: CYP3A5 *1/*3 is associated with decreased concentrations of clozapine in people with schizoaffective disorder or Schizophrenia as compared to CYP3A5 *3/*3.
Notes: This was most pronounced in low CYP3A4 expressers (CYP3A4 was assessed by mRNA levels and grouped into low medium and high). The majority of patients were CYP3A5 non-expressers (*3/*3) and ten carried the *1 allele associated with expression of CYP3A5. Those with CYP3A5*1 and normal/high expression of CYP3A4 may require higher doses/be at greater risk of being underdosed.
Article: Factors Affecting the Metabolic Conversion of Ciprofloxacin and Exposure to Its Main Active Metabolites in Critically Ill Patients: Population Pharmacokinetic Analysis of Desethylene Ciprofloxacin
Gene: CYP1A2
Variant/haplotype: rs762551
Drug(s): ciprofloxacin
Significant: not stated
Association: Genotypes AA + AC is associated with increased clearance of ciprofloxacin in people with Infectious disease as compared to genotype CC.
Notes: as measured by increased metabolite elimination rate constant for carriers of variant alleles of CYP1A2 rs762551. Authors do not specify which allele is considered "v" and which is "wt", reference genomic sequence is C therefore treated "wt" as C.