Question: How many times did plague occur in the birthplace of the person who used the spice route that the Ottoman Empire controlled?

Knowledge 1: Ottoman Empire
The economic structure of the Empire was defined by its geopolitical structure. The Ottoman Empire stood between the West and the East, thus blocking the land route eastward and forcing Spanish and Portuguese navigators to set sail in search of a new route to the Orient. The Empire controlled the spice route that Marco Polo once used. When Vasco da Gama bypassed Ottoman controlled routes and established direct trade links with India in 1498, and Christopher Columbus first journeyed to the Bahamas in 1492, the Ottoman Empire was at its zenith. [SEP] Knowledge 2: In the Footsteps of Marco Polo
In the Footsteps of Marco Polo is a 2008 PBS documentary film detailing Denis Belliveau and Francis O'Donnell's 1993 retracing of Marco Polo's journey from Venice to Anatolia, Persia, India and China. The movie documents the first quest "to visit and document every region Marco Polo claimed to have traveled" using only land and sea methods of transportation. Mike Hale of "The New York Times" writes that the documentary includes how Belliveau and O'Donnell "encountered Mongol horsemen and hostile Chinese security officers and survived a firefight between Afghan factions. In the spirit of Polo's journey -- and to prove a point regarding the authenticity of his account -- they disdained airplanes, traveling by foot, on horses and camels and by jeep, boat and train." A text by the same name as the video, "In the Footsteps of Marco Polo", written by Belliveau and O'Donnell, and published by Rowman & Littlefield, serves as a companion to the documentary film. "In the Footsteps of Marco Polo" has been used by Belliveau to create a unique interdisciplinary educational curriculum that he presents at schools and libraries across the United States and internationally. [SEP] Knowledge 3: Imperialism
With Istanbul as its capital and control of lands around the Mediterranean basin, the Ottoman Empire was at the center of interactions between the Eastern and Western worlds for six centuries. Following a long period of military setbacks against European powers, the Ottoman Empire gradually declined into the late nineteenth century. The empire allied with Germany in the early 20th century, with the imperial ambition of recovering its lost territories, but it dissolved in the aftermath of World War I, leading to the emergence of the new state of Turkey in the Ottoman Anatolian heartland, as well as the creation of modern Balkan and Middle Eastern states, thus ending Turkish colonial ambitions.
Knowledge 1: Ottoman Empire
The economic structure of the Empire was defined by its geopolitical structure. The Ottoman Empire stood between the West and the East, thus blocking the land route eastward and forcing Spanish and Portuguese navigators to set sail in search of a new route to the Orient. The Empire controlled the spice route that Marco Polo once used. When Vasco da Gama bypassed Ottoman controlled routes and established direct trade links with India in 1498, and Christopher Columbus first journeyed to the Bahamas in 1492, the Ottoman Empire was at its zenith. [SEP] Knowledge 2: In the Footsteps of Marco Polo
In the Footsteps of Marco Polo is a 2008 PBS documentary film detailing Denis Belliveau and Francis O'Donnell's 1993 retracing of Marco Polo's journey from Venice to Anatolia, Persia, India and China. The movie documents the first quest "to visit and document every region Marco Polo claimed to have traveled" using only land and sea methods of transportation. Mike Hale of "The New York Times" writes that the documentary includes how Belliveau and O'Donnell "encountered Mongol horsemen and hostile Chinese security officers and survived a firefight between Afghan factions. In the spirit of Polo's journey -- and to prove a point regarding the authenticity of his account -- they disdained airplanes, traveling by foot, on horses and camels and by jeep, boat and train." A text by the same name as the video, "In the Footsteps of Marco Polo", written by Belliveau and O'Donnell, and published by Rowman & Littlefield, serves as a companion to the documentary film. "In the Footsteps of Marco Polo" has been used by Belliveau to create a unique interdisciplinary educational curriculum that he presents at schools and libraries across the United States and internationally. [SEP] Knowledge 3: Black Death
In 1466, perhaps 40,000 people died of the plague in Paris. During the 16th and 17th centuries, the plague was present in Paris around 30 per cent of the time. The Black Death ravaged Europe for three years before it continued on into Russia, where the disease was present somewhere in the country 25 times between 1350 to 1490. Plague epidemics ravaged London in 1563, 1593, 1603, 1625, 1636, and 1665, reducing its population by 10 to 30% during those years. Over 10% of Amsterdam's population died in 1623–25, and again in 1635–36, 1655, and 1664. Plague occurred in Venice 22 times between 1361 and 1528. The plague of 1576–77 killed 50,000 in Venice, almost a third of the population. Late outbreaks in central Europe included the Italian Plague of 1629–1631, which is associated with troop movements during the Thirty Years' War, and the Great Plague of Vienna in 1679. Over 60% of Norway's population died in 1348–50. The last plague outbreak ravaged Oslo in 1654.
Knowledge 1: Ottoman Empire
The economic structure of the Empire was defined by its geopolitical structure. The Ottoman Empire stood between the West and the East, thus blocking the land route eastward and forcing Spanish and Portuguese navigators to set sail in search of a new route to the Orient. The Empire controlled the spice route that Marco Polo once used. When Vasco da Gama bypassed Ottoman controlled routes and established direct trade links with India in 1498, and Christopher Columbus first journeyed to the Bahamas in 1492, the Ottoman Empire was at its zenith. [SEP] Knowledge 2: In the Footsteps of Marco Polo
In the Footsteps of Marco Polo is a 2008 PBS documentary film detailing Denis Belliveau and Francis O'Donnell's 1993 retracing of Marco Polo's journey from Venice to Anatolia, Persia, India and China. The movie documents the first quest "to visit and document every region Marco Polo claimed to have traveled" using only land and sea methods of transportation. Mike Hale of "The New York Times" writes that the documentary includes how Belliveau and O'Donnell "encountered Mongol horsemen and hostile Chinese security officers and survived a firefight between Afghan factions. In the spirit of Polo's journey -- and to prove a point regarding the authenticity of his account -- they disdained airplanes, traveling by foot, on horses and camels and by jeep, boat and train." A text by the same name as the video, "In the Footsteps of Marco Polo", written by Belliveau and O'Donnell, and published by Rowman & Littlefield, serves as a companion to the documentary film. "In the Footsteps of Marco Polo" has been used by Belliveau to create a unique interdisciplinary educational curriculum that he presents at schools and libraries across the United States and internationally. [SEP] Knowledge 3: Ottoman Empire
With Constantinople as its capital and control of lands around the Mediterranean basin, the Ottoman Empire was at the centre of interactions between the Eastern and Western worlds for six centuries. Following a long period of military setbacks against European powers, the Ottoman Empire gradually declined into the late nineteenth century. The empire allied with Germany in the early 20th century, with the imperial ambition of recovering its lost territories, joining in World War I to achieve this ambition on the side of Germany and the Central Powers. While the Empire was able to largely hold its own during the conflict, it was struggling with internal dissent, especially with the Arab Revolt in its Arabian holdings. Starting before the war, but growing increasingly common and violent during it, major atrocities were committed by the Ottoman government against the Armenians, Assyrians and Pontic Greeks. The Empire's defeat and the occupation of part of its territory by the Allied Powers in the aftermath of World War I resulted in the emergence of a new state, Turkey, in the Ottoman Anatolian heartland following the Turkish War of Independence, as well as the founding of modern Balkan and Middle Eastern states and the partitioning of the Ottoman Empire.

Answer: 22