Question: Who is the paternal grandmother of John Tzelepes Komnenos?

Knowledge 1: John Tzelepes Komnenos
John Komnenos , later surnamed Tzelepes (Τζελέπης, "Tzelepēs"), was the son of the "sebastokrator" Isaac Komnenos and grandson of the Byzantine emperor AlexiosI Komnenos.As a young man he followed his father during his exile and wanderings across Asia Minor and the Levant, when for a short time he was married to a daughter of Leo I, ruler of Armenian Cilicia.After the reconciliation between his father and his uncle, Emperor John II Komnenos, in 1138, he returned to the Byzantine court, but defected in the next year to the Danishmendid Turks during a siege of Neocaesarea.From there he moved to the court of the Sultan of Rum, one of whose daughters he married.According to later, and likely invented, tradition, the Ottoman dynasty hailed from one of his offspring. [SEP] Knowledge 2: Isaac Komnenos (son of Alexios I)
Isaac Komnenos or Comnenus (16 January 1093 – after 1152) was the third son of Byzantine Emperor Alexios I Komnenos and Empress Irene Doukaina.He was raised to the high rank of "sebastokrator" by his older brother John II Komnenos in reward for his support, but they later fell out, as Isaac began to covet the throne.In 1130, Isaac and his sons fled to exile after becoming involved in a conspiracy against John.For several years, they wandered in Asia Minor and the Levant, trying to gain support from the local rulers, but ultimately in vain.John's military successes forced Isaac to seek a reconciliation with his brother in 1138, although he did not give up his designs on the throne.In 1139, after his oldest son defected to the Seljuk Turks, Isaac was exiled to Heraclea Pontica.During the struggle for John's succession in 1143, he supported the unsuccessful candidacy of his elder nephew, likewise named Isaac, over his younger nephew Manuel I Komnenos.In 1150, weakened by the onset of an illness, he was forced to retire from public life by Manuel.Isaac then devoted himself to the construction of the monastery of Theotokos Kosmosoteira at Bera (modern Feres) in western Thrace, where he was to be buried.Isaac was noted for his erudition and his patronage of learning, and is considered the author of a number of scholarly and poetic works.He is also notable for rebuilding the Chora Church in Constantinople, where his mosaic donor portrait survives to this day.His younger son Andronikos I Komnenos eventually managed to realize Isaac's ambitions, becoming emperor in 1183–1185, the last of the Komnenian dynasty.
Knowledge 1: John Tzelepes Komnenos
John Komnenos , later surnamed Tzelepes (Τζελέπης, "Tzelepēs"), was the son of the "sebastokrator" Isaac Komnenos and grandson of the Byzantine emperor AlexiosI Komnenos.As a young man he followed his father during his exile and wanderings across Asia Minor and the Levant, when for a short time he was married to a daughter of Leo I, ruler of Armenian Cilicia.After the reconciliation between his father and his uncle, Emperor John II Komnenos, in 1138, he returned to the Byzantine court, but defected in the next year to the Danishmendid Turks during a siege of Neocaesarea.From there he moved to the court of the Sultan of Rum, one of whose daughters he married.According to later, and likely invented, tradition, the Ottoman dynasty hailed from one of his offspring. [SEP] Knowledge 2: Hubba bint Hulail
Hubba bint Hulail was the grandmother of Hashim ibn' Abd Manaf, thus the great- great- great- grandmother of the Islamic" Nabī"( Prophet) Muhammad ibn Abdullah.
Knowledge 1: John Tzelepes Komnenos
John Komnenos , later surnamed Tzelepes (Τζελέπης, "Tzelepēs"), was the son of the "sebastokrator" Isaac Komnenos and grandson of the Byzantine emperor AlexiosI Komnenos.As a young man he followed his father during his exile and wanderings across Asia Minor and the Levant, when for a short time he was married to a daughter of Leo I, ruler of Armenian Cilicia.After the reconciliation between his father and his uncle, Emperor John II Komnenos, in 1138, he returned to the Byzantine court, but defected in the next year to the Danishmendid Turks during a siege of Neocaesarea.From there he moved to the court of the Sultan of Rum, one of whose daughters he married.According to later, and likely invented, tradition, the Ottoman dynasty hailed from one of his offspring. [SEP] Knowledge 2: Diana Guardato
Diana Guardato was a member of the aristocratic Patrician Guardato family, and had three children with King Ferdinand I: Diana Guardato is the 16th- Great Grandmother of His Royal Highness Albert II of Belgium, 15th- Great Grandmother of His Majesty Juan CarlosI of Spain, 17th- Great Grandmother of Philippe of Belgium, 14th- Great Grandmother of His Majesty Manuel II of Portugal, 16th- Great Grandmother of Grand Duke Henri, as well as many others.

Answer: Irene Doukaina