Question: Who were the first immigrants that came to america?
Disambiguated questions and answers: question: Who were the first immigrants that came to north america and established successful colonies?
Who were the first immigrants that came to america, settling in Florida and Mexico?
Who were the first Asian immigrants that came to america?
answer: British and other Europeans
Spaniards
"Luzonians" or Luzon Indians
Filipinos
Natural Questions answer: British and other Europeans (from the Wikipedia article "History of immigration to the United States")