Question: what is the rate limiting enzyme of kreb's cycle
[{'answer': 'Isocitrate dehydrogenase', 'provenance': [{'wikipedia_id': '6818', 'title': 'Citric acid cycle', 'start_paragraph_id': 35, 'start_character': 636, 'end_paragraph_id': 35, 'end_character': 660, 'bleu_score': 1.0, 'section': 'Section::::Regulation.\n'}]}, {'provenance': [{'wikipedia_id': '6818', 'title': 'Citric acid cycle', 'start_paragraph_id': 0, 'start_character': 0, 'end_paragraph_id': 0, 'end_character': 0, 'bleu_score': 1.0, 'meta': {'yes_no_answer': 'NONE', 'annotation_id': 17613922400553356485}, 'section': 'Section::::Abstract.'}]}, {'provenance': [{'wikipedia_id': '6818', 'title': 'Citric acid cycle', 'section': 'Section::::Regulation.\n', 'start_paragraph_id': 35, 'end_paragraph_id': 35, 'meta': {'evidence_span': ['A reduced amount of ADP causes accumulation of precursor NADH which in turn can inhibit a number of enzymes. NADH, a product of all dehydrogenases in the citric acid cycle with the exception of succinate dehydrogenase, inhibits pyruvate dehydrogenase, isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, and also citrate synthase', 'isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, and also citrate synthase. Acetyl-coA inhibits pyruvate dehydrogenase, while succinyl-CoA inhibits alpha-ketoglutarate dehydrogenase and citrate']}}]}]