Question: itai-itai disease was a form of poisoning associated with ingestion of
[{'answer': 'cadmium', 'provenance': [{'wikipedia_id': '546009', 'title': 'Itai-itai disease', 'start_paragraph_id': 2, 'start_character': 27, 'end_paragraph_id': 2, 'end_character': 34, 'bleu_score': 1.0, 'section': 'Section::::Symptoms.\n'}]}, {'answer': 'Cadmium', 'provenance': [{'wikipedia_id': '546009', 'title': 'Itai-itai disease', 'start_paragraph_id': 15, 'start_character': 90, 'end_paragraph_id': 15, 'end_character': 97, 'bleu_score': 1.0, 'section': 'Section::::Treatment.\n'}]}, {'provenance': [{'wikipedia_id': '546009', 'title': 'Itai-itai disease', 'start_paragraph_id': 6, 'start_character': 0, 'end_paragraph_id': 6, 'end_character': 1059, 'bleu_score': 0.9884053071617651, 'meta': {'yes_no_answer': 'NONE', 'annotation_id': 10602849861395836874}, 'section': 'Section::::Cause.\n'}]}, {'provenance': [{'wikipedia_id': '4748913', 'title': 'Four Big Pollution Diseases of Japan', 'section': 'Section::::Itai-itai disease.:Cause of itai-itai.\n', 'start_paragraph_id': 6, 'end_paragraph_id': 6, 'meta': {'evidence_span': ['The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzū River basin.', "The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzū River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzū River in 1910. The cadmium poisoned the river, thus poisoning locals' source of water.", "The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzū River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzū River in 1910. The cadmium poisoned the river, thus poisoning locals' source of water. Any person who drank that water or ate food that was grown with the contaminated water, such as rice, would be likely to show signs of itai-itai disease. The first symptoms were spine and leg pain. However, as the disease progresses symptoms include: Most"]}}]}, {'provenance': [{'wikipedia_id': '546009', 'title': 'Itai-itai disease', 'section': 'Section::::Cause.\n', 'start_paragraph_id': 6, 'end_paragraph_id': 6, 'meta': {'evidence_span': ['Itai-itai disease was caused by cadmium poisoning due to mining in Toyama Prefecture.', 'Itai-itai disease was caused by cadmium poisoning due to mining in Toyama Prefecture.', "Itai-itai disease was caused by cadmium poisoning due to mining in Toyama Prefecture. The earliest records of mining for gold in the area date back to 1710. Regular mining for silver started in 1589, and soon thereafter, mining for lead, copper, and zinc began. Increased demand for raw materials during the Russo-Japanese War and World War I, as well as new mining technologies from Europe, increased the output of the mines, putting the Kamioka Mines in Toyama among the world's top mines. Production increased even more before World War II. Starting in 1910 and continuing through 1945, cadmium was released in significant quantities by mining operations, and the disease first appeared around 1912. Prior to World War II, the mining, controlled by the Mitsui Mining & Smelting Co., Ltd., increased to satisfy the wartime demand. This subsequently increased the pollution of the Jinzū River and its tributaries. The river was used mainly for irrigation of rice fields, but also for drinking water, washing, fishing, and other uses by downstream populations. Due to the cadmium poisoning, the fish in the river started to die, and the rice irrigated with river water did not grow well. The cadmium and other heavy metals accumulated at the bottom"]}}]}, {'provenance': [{'wikipedia_id': '546009', 'title': 'Itai-itai disease', 'section': 'Section::::Cause.\n', 'start_paragraph_id': 9, 'end_paragraph_id': 9, 'meta': {'evidence_span': ['Only in 1955 did Dr. Hagino and his colleagues suspect cadmium as the cause of the disease. Toyama Prefecture also started an investigation in 1961, determining that the Mitsui Mining and Smelting\'s Kamioka Mining Station caused the cadmium pollution and that the worst-affected areas were 30\xa0km downstream of the mine. In 1968, the Ministry of Health and Welfare issued a statement about the symptoms of "itai-itai" disease caused by the cadmium poisoning.', 'In 1968, the Ministry of Health and Welfare issued a statement about the symptoms of "itai-itai" disease caused by the cadmium poisoning.', 'it was thought to be simply a regional disease or a type of bacterial infection. Medical tests started in the 1940s and 1950s, searching for the cause of the disease. Initially, it was expected to be lead poisoning due to the lead mining upstream. Only in 1955 did Dr. Hagino and his colleagues suspect cadmium as the cause of the disease. Toyama Prefecture also started an investigation in 1961, determining that the Mitsui Mining and Smelting\'s Kamioka Mining Station caused the cadmium pollution and that the worst-affected areas were 30\xa0km downstream of the mine. In 1968, the Ministry of Health and Welfare issued a statement about the symptoms of "itai-itai" disease caused by the cadmium poisoning.\rhighlight sentence(s) containing evidence, not only the answer']}}]}]