As a proof of principle Vissers et al. (2003) constructed a genome wide array with a 1 Mb resolution to screen three patients with known, FISH-confirmed microdeletion syndromes, including one with PWS.
为了证明其原理，Vissers等人在2003年制造了具有1Mb分辨率的全基因组范围阵列，以筛查三名具有已知微缺失综合征（经FISH验证）的患者，其中一名患有PWS。