The activities of the A4M are controversial: in 2003 a commentary on the response of the scientific community to the promotion of anti-aging medicine noted that the activities of the A4M were seen as a threat to the credibility of serious scientific research on aging.
A4M的活动备受争议：2003年，一则科学界的评论指出，A4M推销抗衰老药物的活动，已对老龄化研究的公信力造成了严重威胁。