Because the end-to-end principle is one of the central design principles of the Internet, and because the practical means for implementing data discrimination violate the end-to-end principle, the principle often enters discussions about net neutrality.
因為終端對終端原則是網際網路的核心設計原則，且因為實務上執行數據差別待遇的方法會違反終端對終端原則，該原則通常會在網路中立性的討論中被提及。