Introduced to replace slower propeller driven cargo planes such as the C-124 Globemaster II and C-133 Cargomaster, the C-141 was designed to requirements set in 1960 and first flew in 1963.
为了取代C-124 Globemaster II和C-133 Cargomaster等速度较慢的螺旋桨运输机，C-141依照1960年的要求设计，并于1963年首次飞行。