While comedy was emphasized in the majority of the episodes, Ferguson also addressed difficult subject matters, such as the deaths of his parents, his struggles with alcoholism, and commenting on national tragedies; and undertook serious interviews, such as one with Archbishop Desmond Tutu, which earned the show a 2009 Peabody Award.
Nors laidoje pagrindinį akcentą atliko komedija, Fergiusonas taip pat aptardavo ir sunkesnes temas, kaip antai jo tėvų mirtį, jo kovą su alkoholizmu, nacionalines tragedijas bei vedė rimtus interviu, kaip antai pokalbį su arkivyskupu Desmond Tutu, kuris 2009 m. laidai pelnė Peabody apdovanojimą.