Methotrexate was made in 1947 and initially came into medical use to treat cancer, as it was less toxic than the then-current treatments.
메토트렉세이트는 1947년 개발되어 처음에는 암 치료를 위해 의학용으로 사용되기 시작했으며 현재의 치료방식보다 독성이 덜했다.