Guidobaldo was sickly and impotent, and they had no children, but Elisabetta refused to divorce him and nursed him through his illnesses.
구이도발도는 병약하고 성적으로 무능력하였기에, 그들은 자식을 두지 못했으나, 엘리사베타는 이혼을 거부하고 그의 병을 간호하였다.