On 27 September 2006, against Bayern Munich, Zanetti played his 500th professional match for Inter and on 22 November 2006, he appeared in his 100th UEFA match, against Sporting Clube de Portugal.
Pada tanggal 27 September 2006, melawan Bayern Munich, Zanetti memainkan pertandingan 500 profesionalnya untuk Inter dan pada tanggal 22 November 2006, ia tampil dalam pertandingan ke-100 Eropa melawan Sporting Lisbon.