In the sixth century, under Pope Gregory I, both the castle and the bridge took on the name Sant'Angelo, explained by a legend that an angel appeared on the roof of the castle to announce the end of the plague.
Pada abad keenam, pada masa Paus Gregorius I, jembatan dan kastil ini diberi nama Sant'Angelo karena menurut legenda seorang malaikat muncul di atap benteng untuk mengumumkan akhir wabah pes.