According to diplomatic cables, U.S. interests in Tajikistan include: "a stable state on Afghanistan’s northern border, support for our military efforts in Afghanistan, and for Tajikistan to be a stabilizing influence and contributor to economic development in the region."
Menurut kawat diplomatik, kepentingan A.S. di Tajikistan meliputi: "kestabilan perbatasan utara Afghanistan, bantuan untuk operasi militer di Afghanistan, dan Tajikistan menjadi kekuatan penyeimbang dan kontributor bagi pengembangan ekonomi di kawasan ini."