In March 2007, Cheadle starred with comedian Adam Sandler in Mike Binder's Reign Over Me, a comedy-drama about a man who has slipped away from reality after his wife and three daughters died.
Pada Maret 2007, Cheadle membintangi film komedi bersama Adam Sandlerdalam Mike Binder's Reign Over Me, sebuah drama-komedi tentang seorang pria yang melarikan dari kehidupan nyata setelah istrinya dan tiga putrinya meninggal dunia.