Shortly after the release of the game, Naughty Dog's co-president, Evan Wells, stated that Uncharted had been developed as a franchise, and so a sequel was likely.
Tak lama setelah rilis permainan, co-presiden Naughty Dog, Evan Wells, menyatakan bahwa Uncharted telah dikembangkan sebagai waralaba, dan sekuel kemungkinan.