Indeed, this confounds the interpretation of p105-knockout studies, where the genetic manipulation is removing an IκB (full-length p105) and a likely repressor (p50 homodimers) in addition to a transcriptional activator (the RelA-p50 heterodimer).
Memang, hal ini membingungkan pada interpretasi penelitian p105-knockout, yang mana manipulasi genetik menyingkirkan IκB (p105 penuh) dan kemungkinan represor (p50 homodimer) selain aktivator transkripsi (heterodimer RelA-p50).