Following his father's death, Seleucus VI declared himself king and took the city of Seleucia on the Calycadnus in western Cilicia as his base, while his brother Demetrius III took Damascus.
Setelah kematian ayahandanya, Seleukos VI mendeklarasikan dirinya sebagai raja dan mengambil kota Seleukia di Calycadnus di Kilikia barat sebagai basisnya, sementara saudaranya Demetrios III mengambil Damaskus.