During Darius's campaign against the invasion by Alexander the Great, Parysatis and her sisters, along with many other members of the Persian elite, accompanied the Persian army.
Selama kampanye Darius melawan serangan Aleksander Agung, Parysatis dan saudari-saudarinya, bersama dengan banyak anggota elit Persia lainnya, menemani tentara Persia.