A section of US 22 in Pennsylvania between New Alexandria at U.S. Route 119 and Harrisburg at Interstate 81 has been designated a part of Corridor M of the Appalachian Development Highway System.
Bagian US 22 antara New Alexandria di U.S. Route 119 dan Harrisburg di Interstate 81 telah ditetapkan sebagai bagian dari Corridor M pada sistem Appalachian Development Highway System.