During the anti-Christian persecutions in 1596, many Japanese Christians fled to Macau and other Portuguese colonies such as Goa, where there was a community of Japanese slaves and traders by the early 17th century.
Pada saat penganiayaan anti-Kristen pada 1596, beberapa Kristen Jepang kabur ke Makau dan koloni-koloni Portugis lainnya seperti Goa, dimana terdapat komunitas budak dan perdagang Jepang pada awal abad ke-17.