By 1830, the Sisters were running orphanages and schools as far west as Cincinnati and New Orleans, and had established the first hospital west of the Mississippi in St. Louis.
Pada tahun 1830, para suster kongregasinya mengelola berbagai panti asuhan dan sekolah hingga ke daerah barat, yaitu Cincinnati dan New Orleans, dan telah mendirikan rumah sakit pertama di sebelah barat Mississippi, di St. Louis.