On 6 August 2011, Lamela joined Italian club Roma of Serie A for a fee of €12 million, plus €2 million in bonuses, which was activated after his 20th club appearance.
Pada tanggal 6 Agustus 2011, Lamela bergabung di Serie A dengan klub AS Roma dengan biaya € 12 juta, ditambah bonus € 2.000.000 (yang diaktifkan setelah penampilan ke-20).