The show follows the adventures of stepbrothers Phineas Flynn (Vincent Martella) and Ferb Fletcher (Thomas Sangster), who live in the fictional city of Danville, in a (never specified) tri-state area, as they seek ways to occupy their time during their summer vacation.
Acara ini mengikuti petualangan saudara tiri Phineas Flynn (Vincent Martella) dan Ferb Fletcher (Thomas Sangster), yang tinggal di kota fiksi Danville, di daerah tiga negara bagian (tidak pernah ditentukan), karena mereka mencari cara untuk mengisi waktu mereka selama liburan musim panas mereka.