Brazil–Uruguay relations encompass many complex relations over the span of three centuries, beginning in 1680 with the establishment of the Colônia do Sacramento, to the present day, between the Federative Republic of Brazil and the Oriental Republic of Uruguay.
Hubungan Brasil–Uruguay meliputi beberapa hubungan kompleks sepanjang tiga abad, bermula pada 1680 dengan pendirian Colônia do Sacramento, sampai saat ini, antara Republik Federatif Brasil dan Republik Oriental Uruguay.