The Japanese author Sawako Ariyoshi wrote a novel entitled The Doctor's Wife (Japanese 華岡青洲の妻), based on the actual life of Hanaoka Seishū mixed with a fictional conflict between his mother and his wife.
Penulis asal Jepang Sawako Ariyoshi menulis sebuah novel berjudul, The Doctor's Wife (berbahasa Jepang 華岡青洲の妻), yang diangkat berdasarkan kehidupan nyata Hanaoka Seishū yang bercampur dengan konflik fiksi antara ibu dan istrinya.