Isabella was pregnant at that time and, while in Zaragoza with the royal family, she gave birth on 23 August 1498 to her only child, Miguel da Paz, Prince of Portugal.
Isabel sedang hamil pada saat itu, sementara di Zaragoza bersama keluarga kerajaan, ia melahirkan pada tanggal 23 Agustus 1498 putra tunggalnya, Miguel da Paz, Pangeran Portugal.