Sweeney is best known for her portrayal of Samantha "Sami" Brady on the NBC soap opera Days of Our Lives, a role she has played under contract with the show since January 6, 1993.
Sweeney terkenal karena perannya sebagai Samantha "Sami" Brady pada opera sabun NBC Days of Our Lives, peran telah ia mainkan di bawah kontrak dengan acara tersebut sejak 6 Januari 1993.