Early chemists discovered that the reason for the variability in the ratio of Markovnikov to anti-Markovnikov reaction products was due to the unexpected presence of free radical ionizing substances such as peroxides.
Ahli kimia awal menemukan bahwa alasan variabilitas rasio produk reaksi Markovnikov terhadap anti-Markovnikov adalah karena kehadiran tak diharapkan zat pengion radikal bebas seperti peroksida.