The Mixtecan languages (in their many variants) were estimated to be spoken by about 300,000 people at the end of the 20th century, although the majority of Mixtec speakers also had at least a working knowledge of the Spanish language.
Bahasa Mixtec diperkiraan dipertuturkan oleh 300.000 orang pada akhir abad ke-20, walaupun kebanyakan penutur Mixtec juga mampu bertutur bahasa Spanyol.