An oral direct thrombin inhibitor, ximelagatran (Exanta) was denied approval by the Food and Drug Administration (FDA) in September 2004 and was pulled from the market entirely in February 2006 after reports of severe liver damage and heart attacks.
Sebuah inhibitor trombin langsung oral, ximelagatran (Exanta) ditolak persetujuan oleh Food and Drug Administration (FDA) pada bulan September 2004 dan ditarik dari pasar seluruhnya pada bulan Februari 2006 setelah laporan kerusakan hati dan serangan jantung yang parah.