The years of struggle with Rome, the antagonisms with and among his fellow reformers, and the scandal that ensued from the bigamy of Philip I, Landgrave of Hesse incident, in which Luther had played a leading role, all may have contributed.
Tahun-tahun pergulatan dengan Roma, antagonisme dengan dan di antara sesamanya para reformis, serta skandal yang terjadi akibat insiden bigami Philipp I, Landgraf Hessen, yang di dalamnya Luther memainkan suatu peran utama, semuanya mungkin berkontribusi terhadap kesehatannya.