In 1906, antiserum was produced in horses; this was developed further by the American scientist Simon Flexner and markedly decreased mortality from meningococcal disease.
Pada 1906, antiserum diproduksi di kuda; hal ini dikembangkan lebih lanjut oleh seorang ilmuwan Amerika Simon Flexner dan secara nyata menurunkan mortalitas dari penyakit meningokokus.