Since 1987, Horwich and his colleagues have been studying these molecules both in vivo and in vitro, with particular emphasis on the Hsp60 homologue in E. coli known as GroEL.
Sejak 1987, Horwich dan koleganya meneliti molekul tersebut baik secara vivo maupun in vitro, dengan perhatian khusus pada homolog Hsp60 E. coli yang dikenal sebagai GroEL.