Pier Luigi Alexander Farnese was born in 1503 from the union between Cardinal Alexander Farnese (future Pope Paul III) and probably Silvia Ruffini - a Roman noblewoman who also gave birth with Alexander to three other children: Constanza, Paul and Ranuccio.
Pier Luigi Alexander Farnese lahir pada 1503 dari Kardinal Alexander Farnese (kelak Paus Paulus III) dan mungkin Silvia Ruffini - seorang wanita bangsawan Roma yang juga memiliki tiga anak lainnya: Constanza, Paul dan Ranuccio.