By her marriage she had become a member of the powerful Guise family, and because of her Italian roots she had especially close ties to the queen and later queen-mother, Catherine de' Medici.
Melalui pernikahannya dia telah menjadi anggota Wangsa Guise yang kuat, dan karena akar Italia dia memiliki hubungan sangat dekat dengan ratu dan kemudian ibu suri, Catherine de' Medici.