Like the other very large viruses Mimivirus and Megavirus, Pandoravirus infects amoebas, but its genome, containing 1.9 to 2.5 megabases of DNA, is twice as large as that of Megavirus, and it differs greatly from the other large viruses in appearance and in genome structure.
Seperti virus sangat besar lainnya (Mimivirus dan Megavirus), Pandoravirus menginfeksi ameba, namun genomnya, yang terdiri dari 1,9 hingga 2,5 megabasa DNA, dua kali lebih besar dari Megavirus, dan penampilan serta struktur genomnya sangat berbeda dengan virus besar lainnya.