Before railroads and highways were developed, the Rhône was an important inland trade and transportation route, connecting the cities of Arles, Avignon, Valence, Vienne and Lyon to the Mediterranean ports of Fos-sur-Mer, Marseille and Sète.
Sebelum rel dan jalan raya ditemukan, Rhone adalah sebuah rute dagang dan transportasi darat penting, menghubungkan kota Arles, Avignon, Valence, Vienne dan Lyon ke pelabuhan Mediterania Fos, Marseille dan Sète.