Since 1840, the United States has had diplomatic representation in the Italian Republic and its predecessor nation, the Kingdom of Italy, with a break in relations from 1941 to 1944 while Italy and the U.S. were at war during World War II.
Sejak tahun 1840, Amerika Serikat telah memiliki perwakilan diplomatik di Republik Italia dan negara pendahulunya, Kerajaan Italia, dengan pemutusan hubungan dari 1941 sampai 1944 saat Italia dan AS berperang pada Perang Dunia II.