Assassin's Creed III is structured similarly to the previous games, with missions taking place on an open-world map based on Colonial Boston and New York, and offers a large wilderness area, the Frontier and in the Davenport Homestead, where the player can hunt animals for materials, which then subsequently can be used to construct goods to be traded and sold throughout the colonies.
Assassin's Creed III terstruktur mirip dengan permainan sebelumnya, dengan misi yang bertempat pada peta dunia terbuka berdasarkan Kolonial Boston dan New York, dan memberikan wilayah yang lebih luas, di Frontier dan di Davenport Homestead, di mana pemain dapat berburu hewan, yang bahan-bahannya dapat digunakan untuk berdagang komoditas di seluruh koloni.