He died on 25 January 1494, worn out with anxiety; he was succeeded by his son, Alphonse, Duke of Calabria, who was soon deposed by the invasion of King Charles which his father had so feared.
Ia meninggal pada tanggal 25 Januari 1494, lelah karena kecemasan; ia digantikan oleh putranya, Alfonso, Adipati Calabria, yang segera digulingkan oleh invasi Raja Charles yang begitu ditakuti ayahandanya.