The presence of the Spanish in the Eastern Mediterranean concerned Suleiman, who saw it as an early indication of Charles V's intention to rival Ottoman dominance in the region.
Kehadiran pasukan Spanyol di Mediterania Timur menimbulkan kekhawatiran Suleiman, yang melihat itu sebagai indikasi bahwa Karl V mencoba mengganggu dominasi Utsmaniyah di kawasan.