His work has covered themes of galactic conflict (Forge of God books), artificial universes (The Way series), consciousness and cultural practices (Queen of Angels), and accelerated evolution (Blood Music, Darwin's Radio, and Darwin's Children).
Karyanya meliputi tema-tema konflik galaktik (buku-buku Forge of God), alam-alam buatan (serial The Way), hati nurani dan praktik kebudayaan (Queen of Angels), dan evolusi terakselerasi (Blood Music, Darwin's Radio, dan Darwin's Children).