In addition to acting in films, Sen has also been directing films since 1981, starting with 36 Chowringhee Lane for which she won National Film Award (India) for Best Director.
Selain berakting dalam film, sen juga menyutradarai film sejak 1981 dengan "36 Chowringhee Lane" yang membuatnya memenangkan Penghargaan Film Nasional (India) untuk Sutradara Terbaik.