Set in 1890, the film follows the last 67 days of Van Gogh's life and explores his relationships with his brother Theo, his physician Paul Gachet (most famous as the subject of Van Gogh's painting Portrait of Dr. Gachet), and the women in his life, including Gachet's daughter, Marguerite.
Berlatar belakang tahun 1890, film tersebut berkisah tentang 67 hari terakhir kehidupan Van Gogh dan menyoroti hubungannya dengan saudaranya Theo, dokternya Paul Gachet (dikenal sebagai subyek dari lukisan Van Gogh Potret Dr. Gachet), dan kaum wanita dalam hidupnya, termasuk putri Gachet, Marguerite.