Although the outbreak was centered on Tupelo, Mississippi, and Gainesville, Georgia, where the fourth and fifth deadliest tornadoes in U.S. history respectively occurred, other destructive tornadoes associated with the outbreak struck Columbia, Tennessee; Anderson, South Carolina; and Acworth, Georgia.
Meskipun perebakan tersebut berpusat di Tupelo, Mississippi, dan Gainesville, Georgia, dimana tornado paling mematikan keempat dan kelima dalam sejarah AS masing-masing terjadi, tornado destruktif lainnya yang berkaitan dengan perebakan tersebut menyerang Columbia, Tennessee; Anderson, South Carolina; dan Acworth, Georgia.