Not having any political power and repeatedly being forced out of the capital of Kyoto, Yoshiharu retired in 1546 over a political struggle between Miyoshi Nagayoshi and Hosokawa Harumoto making his son Ashikaga Yoshiteru the thirteenth shogun.
Tidak memiliki kekuatan politik dan berulang kali dipaksa keluar dari ibukota Kyoto, Yoshiharu pensiun pada 1546 karena pertarungan politik antara Miyoshi Nagayoshi dan Hosokawa Harumoto membuat putranya Ashikaga Yoshiteru shogun ketiga belas.