After Gizenga, the leader of PALU, resigned as Prime Minister on 25 September 2008 for reasons related to age and health, Muzito was appointed as his successor by President Joseph Kabila on 10 October 2008.
Setelah Gizenga, pemimpin PALU, mundur sebagai Perdana Menteri tanggal 25 September 2008 karena alasan usia dan kesehatan, Muzito ditunjuk oleh Presiden Joseph Kabila untuk menggantikan Gizenga pada 10 Oktober 2008.