However, he can still suffer the immediate effects of such substances in massive quantities; he has been shown to become intoxicated after ingesting significant amounts of alcohol, and has been incapacitated on several occasions with large amounts of powerful drugs and poisons; S.H.I.E.L.D. once managed to keep Wolverine anesthetized by constantly pumping eighty milliliters of anesthetic a minute into his system.
Namun, ia masih dapat menderita efek langsung zat-zat tersebut dalam jumlah besar; ia telah terbukti menjadi mabuk setelah meminum sejumlah besar alkohol, dan telah lumpuh pada beberapa kesempatan dengan jumlah besar obat kuat dan racun; S.H.I.E.L.D. sekali berhasil menjaga Wolverine dibius dengan terus-menerus memompa delapan puluh mililiter permenit anestesi ke dalam sistemnya.