Of greatest notoriety is the film's capture of the fatal shot to President Kennedy's head when his presidential limousine was almost exactly in front of, and slightly below, Zapruder's position.
Cuplikan terbesarnya adalah saat film tersebut menangkap tembakan fatal ke kepala Presiden Kennedy saat limousine presidensialnya berada hampir di depan, dan di bawah, posisi Zapruder.