In a study where the N-terminus was removed up to N342 (the start of the GPS), the receptor became constitutively active and an up regulation of Gα12/13 was seen.
Dalam sebuah studi di mana N-terminus dipindahkan hingga N342 (awal GPS), reseptor menjadi aktif secara konstitutif dan terlihat adanya regulasi Gα12/13.