Characteristic motifs indicate that three of the five GRAFS families, Rhodopsin, Adhesion, and Frizzled, evolved from the Dictyostelium discoideum cAMP receptors before the split of Opisthokonts.
Motif karakteristik menunjukkan bahwa tiga dari lima famili GRAFS, Rhodopsin, Adhesi, dan Frizzled, berevolusi dari reseptor cAMP Dictyostelium discoideum sebelum pemisahan Opisthokonts.