Natsume's Book of Friends has been adapted as a series of drama CDs, as well as an anime television series produced by Brain's Base (seasons 1-4) and Shuka (seasons 5-6), which was broadcast on TV Tokyo for 6 seasons in 2008, 2009, 2011, 2012, 2016 and 2017.
Natsume Yuujinchou telah diadaptasi menjadi sebuah serial drama CD dan juga sebuah serial televisi anime yang diproduksi oleh Brain's Base (musim 1-4) dan Shuka (musim 5-6) dan ditayangkan oleh TV Tokyo dengan total 6 musim pada tahun 2008, 2009, 2011, 2012, 2016, dan 2017.