The blood-derived hepatitis B vaccine was withdrawn from the marketplace in 1986 when Pablo DT Valenzuela, Research Director of Chiron Corporation, succeeded in making the antigen in yeast and invented the world's first recombinant vaccine.
Vaksin turunan darah hepatitis B ditarik dari pasaran pada tahun 1986 ketika Pablo DT Valenzuela, Direktur Penelitian Chiron Corporation, berhasil membuat antigen dalam ragi dan menemukan vaksin rekombinan pertama di dunia.