For the first four seasons under the Medical Detectives name, the format of the show was generally the same as it would be in later seasons under its "Forensic Files" name, but there were slight differences.
Untuk empat musim pertama di bawah nama Medical Detectives, format acara ini umumnya sama karena akan di musim selanjutnya akan berada di bawa label "Forensic Files", tetapi ada sedikit perbedaan.