While Clapton was shy about singing, he occasionally harmonised with Bruce and, in time, took lead vocals on several Cream tracks including "Four Until Late", "Strange Brew", "World of Pain", "Outside Woman Blues", "Crossroads", and "Badge".
Sementara pada waktu itu Clapton malu bernyanyi, ia kadang-kadang mengisi harmonisasi dengan Bruce dan, seiring waktu, ia mengambil peran lead vokal pada beberapa trek Cream seperti "Four Until Late", "Strange Brew", "World of Pain", "Outside Woman Blues", "Anyone for Tennis", "Crossroads", dan "Badge".