In 1043 his army clashed with troops loyal to Constantine near Thessalonika, and though initially successful, Maniakes was killed during the melee after receiving a fatal wound (according to Psellus' account).
Pada tahun 1043 pasukannya bentrok dengan pasukan yang setia pada Constantine di dekat Tesalonika, dan meskipun awalnya menang, Maniakes terbunuh setelah terluka parah dalam pertarungan jarak dekat (menurut laporan Psellus).