F a b s = 100 ⋅ A U C p o ⋅ D i v A U C i v ⋅ D p o {\displaystyle F_{\mathrm {abs} }=100\cdot {\frac {AUC_{\mathrm {po} }\cdot D_{\mathrm {iv} }}{AUC_{\mathrm {iv} }\cdot D_{\mathrm {po} }}}} Therefore, a drug given by the intravenous route will have an absolute bioavailability of 100% (f = 1), whereas drugs given by other routes usually have an absolute bioavailability of less than one.
F a b s = 100 ⋅ A U C p o ⋅ D i v A U C i v ⋅ D p o {\displaystyle F_{abs}=100\cdot {\frac {AUC_{po}\cdot D_{iv}}{AUC_{iv}\cdot D_{po}}}} Oleh karena itu, obat yang diberikan secara intravena akan memiliki bioavailabilitas absolut sebesar 100% (f=1), sedangkan obat-obatan yang diberikan melalui rute lain biasanya memiliki bioavailabilitas absolut kurang dari satu.