While comedy was emphasized in the majority of the episodes, Ferguson also addressed difficult subject matters, such as the deaths of his parents, his struggles with alcoholism, and commenting on national tragedies; and undertook serious interviews, such as one with Archbishop Desmond Tutu, which earned the show a 2009 Peabody Award.
Sementara sebagian besar episode berfokus pada komedi, Ferguson juga telah membahas subyek yang sulit, seperti kematian orang tuanya, dan wawancara yang dilakukan serius, misalnya salah satunya dengan Desmond Tutu, yang memenangkan Penghargaan Peabody 2009.