Its responsibilities include the nation's nuclear weapons program, nuclear reactor production for the United States Navy, energy conservation, energy-related research, radioactive waste disposal, and domestic energy production.
Cakupan tugasnya meliputi program senjata nuklir nasional, pembuatan reaktor nuklir untuk Angkatan Laut Amerika Serikat, konservasi energi, penelitian energi, pembuangan limbah radioaktif, dan produksi energi dalam negeri.