After the election of Amadou Toumani Touré as President, Issoufi became Minister of the Economy and Finance on June 14, 2002, serving under Prime Minister Ahmed Mohamed ag Hamani.
Setelah Amadou Toumani Touré terpilih sebagai presiden, Issoufi bergabung ke pemerintahan Perdana Menteri Ahmed Mohamed ag Hamani pada 14 Juni 2002 sebagai Menteri Keuangan.