Since no candidate received more than 50% of the votes, a run-off election was held on 28 December 2008 between the two candidates who received the most votes, Nana Akufo-Addo and John Atta Mills.
Karena tidak ada kandidat yang menerima lebih dari 50% suara, pemilihan ronde dua diadakan pada 28 Desember 2008 antara dua kandidat yang menerima suara paling banyak, Nana Akufo-Addo dan John Atta Mills.