During the 1980s and early 1990s, Prost formed a fierce rivalry mainly with Ayrton Senna, but also Nelson Piquet and Nigel Mansell.
Selama 1980-an dan sampai awal 1990-an, Prost membentuk persaingan sengit dengan beberapa pembalap, terutama Ayrton Senna, dan juga Nelson Piquet serta Nigel Mansell.