Starting from humble beginnings he rose to the heights of power becoming a religious reformer, twice regent of Spain, Cardinal, Grand Inquisitor, promoter of the Crusades in North Africa, and founder of the Complutense University, today the Complutense University of Madrid.
Dimulai dari permulaan pelayanan, ia meraih kekuasaan tinggi dengan menjadi reformer keagamaan, dua kali menjadi wali raja Spanyol, Kardinal, Inkuisitor Besar, promoter Perang Salib di Afrika Utara, dan pendiri Universitas Complutense, sekarang Universitas Complutense Madrid.