It is located with San Jose to its south and Fremont to its north, at the eastern end of State Route 237 and generally between Interstates 680 and 880 which run roughly north/south through the city.
Kota Milpitas terletak bersebelahan dengan San Jose ke selatan dan Fremont di sebelah utara, di timur akhir dari State Route 237 dan pada umumnya di antara Interstates 680 dan 880 yang membentang sekitar utara/selatan.