The production model was unveiled in the Thailand International Motor Expo 2010 on November 27, 2010, Hong Kong's Central District on November 28, 2010, and EICMA 2010 Global models of the CBR250R were produced by Thai Honda Manufacturing in Thailand, with sales beginning in November 2010, followed by spring 2011 in Japan.
Model produksi diluncurkan pada Thailand International Motor Expo 2010 pada 27 November 2010, Hong Kong Central District pada 28 November 2010, dan EICMA 2010 Model global CBR250R diproduksi oleh Pabrik Honda Thai di Thailand, dengan penjualan dimulai pada November 2010, dilanjutkan pada musim semi 2011 di Jepang.