The College of Cardinals apparently preferred rule by nephews than by favorites, which they perceived as the alternative; for example, the College urged Pope Benedict XIII (1724–1730) to appoint a cardinal-nephew, who they hoped would replace Benedict XIII's notorious lieutenant Niccolò Coscia.
Dewan Kardinal lebih sering dipimpin oleh keponakan ketimbang orang terpilih, yang mereka anggap sebagai pilihan alternatif; contohnya, Dewan meminta Paus Benediktus XIII (1724–1730) untuk melantik seorang kardinal keponakan, yang mereka harap menggantikan letnan kepercayaan Benediktus XIII Niccolò Coscia.