Although Tizoc's reign was relatively short, he began the rebuilding of the Great Pyramid of Tenochtitlan (a task completed by his younger brother in 1487), and also put down a rebellion of the Matlatzincan peoples of the Toluca Valley.
Walaupun masa kekuasaan Tizoc berlangsung relatif singkat, ia mulai pembangunan kembali Piramida Agung Tenochtitlan (yang diselesaikan oleh adiknya pada tahun 1487), dan berhasil memadamkan pemberontakan orang Matlatzinca di Lembah Toluca.