Although the box jellyfish has been called "the world's most venomous creature", only a few species in the class have been confirmed to be involved in human deaths, and some species pose no serious threat at all.
Ubur-ubur kotak disebut "makhluk laut paling berbisa di dunia", meskipun hanya beberapa spesies di dalam kelas telah dikonfirmasi untuk bisa terlibat dalam kematian manusia dan beberapa spesies tidak menimbulkan ancaman serius.