Carl Woese and Otto Kandler with Wheelis wrote the important paper Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya that proposed a change from the Two-empire system of Prokaryotes and Eukaryotes to the Three-domain system of the domains Eukaryota, Bacteria and Archaea.
Carl Woese dan Otto Kandler dengan Wheelis menulis kertas penting Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya yang mengusulkan perubahan dari sistem dua-empire Prokariota dan Eukariota menjadi sistem tiga domain dari domain Eukaryota, Bacteria dan Archaea.