Approximately 45 An-22s remained in service by the mid-1990s, mostly with the Russian Air Force, but these are slowly being replaced by the bigger turbofan-powered Antonov An-124.
Sekitar 45 pesawat masih aktif pada pertengahan tahun 1990an, terutama di Angkatan Udara Rusia, namun secara perlahan digantikan degan pesawat turbofan yang lebih bertenaga Antonov An-124.