She was distressed by her husband's bouts of physical and mental illness, which became permanent in later life and resulted in their eldest son's appointment as Prince Regent in 1811.
Dia tertekan oleh serangan suaminya dari penyakit fisik dan kegilaan, yang menjadi permanen di kemudian hari dan mengakibatkan anak sulung mereka yang ditunjuk Pangeran Bupati tahun 1810.