Odessa's population was 118,918 at the 2010 census, making it the 29th-most populous city in Texas; estimates as of July 2015 indicate a population of 159,436 in the city.
Populasi Odessa berjumlah 118,918 menurut sensus tahun 2010, menjadikannya kota terpadat ke-29 di Texas; perkiraan Juli 2015 menyatakan bahwa populasinya berjumlah 159,436.