Michael II's relations with Nicaea ensured his neutrality during the conflict in which John III Doukas Vatatzes conquered Thessalonica and penetrated into northern Greece in 1244–46.
Hubungan Mikhael II dengan Nicea memastikan kenetralannya selama konflik di mana Ioannis III Doukas Vatatzes menaklukkan Tesalonika dan menembus ke Yunani utara pada tahun 1244-46.