The Bank was founded by Pope Paul V in the Bench of S. Spirit building (which became known as the Palazzo del Banco di S. Spirito) on December 13, 1605.
Bank ini didirikan oleh Paus Paulus V di gedung Mahkamah Roh Kudus (yang kemudian dikenal sebagai Palazzo del Banco di S. Spirito) pada tanggal 13 Desember 1605.