The discovery of the artificial synthesis of urea contributed greatly to the theory of isomerism, as the empirical chemical formulas for urea and ammonium cyanate are identical (see Wöhler synthesis).
Penemuan sintesis urea buatan memberikan kontribusi besar terhadap teori isomerisme, karena rumus kimia empiris untuk urea dan amonium sianat identik (lihat sintesis Wöhler).