The real breakthrough came with an international chemical congress held in the German town of Karlsruhe in September 1860, at which most of the leading European chemists were present.
Terobosan sesungguhnya datang dengan sebuah kongres kimia internasional yang diadakan di kota Karlsruhe, Jerman pada bulan September 1860, di mana sebagian besar kimiawan terkemuka Eropa hadir.