Born into a poor family, Moscoso became active in the 1968 presidential campaign of three-time president Arnulfo Arias, following and marrying him when he went into exile after a military coup.
Lahir dalam sebuah keluarga miskin, Moscoso menjadi aktif dalam kampanye presidensial 1968 dari presiden tiga kali Arnulfo Arias, setelah menikahinya saat ia diasingkan karena kudeta militer.