TransMilenio's main routes are: Caracas Avenue, Northern Highway (Autopista Norte), 80th Street, Americas Avenue, Jiménez Avenue, and 30th Avenue (also referred to as Norte Quito Sur or N.Q.S. for short).
Rute utama TransMilenio adalah: Avenida Caracas, Jalan 80, Avenida Americas, Jalur cepat Utara (Autopista Norte), Avenida Jiménez, dan Avenida 30 (juga dirujuk sebagai Norte Quito Sur atau N.Q.S.).