Teaching began in 1965 in Blantyre, and within two years the Institute of Public Administration at Mpemba, the Soche Hill College of Education and the Polytechnic in Blantyre, and Bunda College in Lilongwe became colleges of the university.
Pengajaran dimulai pada tahun 1965 di Blantyre, dan dalam waktu dua tahun Institut Administrasi Umum di Mpemba, Kolese Pendidikan Soche Hill, dan Politeknik di Blantyre, serta Kolese Bunda di Lilongwe menjadi kolese universitas ini.