Amenhotep inherited a vast kingdom from his father Thutmose III, and held it by means of a few military campaigns in Syria; however, he fought much less than his father, and his reign saw the effective cessation of hostilities between Egypt and Mitanni, the major kingdoms vying for power in Syria.
Amenhotep mewarisi kerajaan yang luas dari ayahnya, Thutmose III, dan mempertahankannya dengan sejumlah serangan militer ke Siria; tetapi, ia berperang lebih sedikit daripada ayahnya, dan dalam pemerintahannya berakhirlah permusuhan antara Mesir dan Mitanni, dua kerajaan besar yang berebut kekuasaan di Siria.