In 2007, he replaced Amitabh Bachchan for one season as the host of Kaun Banega Crorepati, the Indian version of Who Wants to Be a Millionaire?, and a year later, Khan began hosting Kya Aap Paanchvi Pass Se Tez Hain?, the Indian version of Are You Smarter Than a 5th Grader?.
Pada 2007, ia menggantikan Amitabh Bachchan selama satu musim sebagai pembawa acara Kaun Banega Crorepati, versi India dari Who Wants to Be a Millionaire?, dan setahun kemudian, Khan mulai memandu acara Kya Aap Paanchvi Pass Se Tez Hain?, versi Indian dari Are You Smarter Than a 5th Grader?.