Such exposure to pepsin at neutral pH and endocyctosis of pepsin causes changes in gene expression associated with inflammation, which underlies signs and symptoms of reflux, and tumor progression.
Esta exposición á pepsina a pH neutro e a endocitose da pepsina causa cambios na expresión xenética asociada coa inflamación, o que está na base dos signos e síntomas do refluxo, e na progresión de tumores.