The definitive experiments that showed that targeted therapy would reverse the malignant phenotype of tumor cells involved treating Her2/neu transformed cells with monoclonal antibodies in vitro and in vivo by Mark Greene’s laboratory and reported from 1985.
Os experimentos definitivos que amosaron que a terapia dirixida sería dar a volta o fenotipo maligno das células tumorais implicando tratamento de células Her2/neu transformadas con anticorpos monoclonales in vitro e in vivo polo laboratorio de Mark Greene, isto a través dun informe de 1985.