However, mutation of the final amino acid of the motif, M173, which is unable to bind PI3K but is able to bind Grb2 and Gads, gives little NF-κB or IL-2, suggesting that those Grb2 and Gads are unable to compensate for the loss of PI3K.
Porén, a mutación do aminoácido final do motivo, M173, que non se pode unir a PI3K pero pode unirse a Grb2 e Gads, proporciona pouco NF-κB ou IL-2, o que suxire que Grb2 e Gads son incapaces de compensar a perda de PI3K.