For instance, ANRIL, in addition to the ability to induce DNA methylation, can also repress the neighboring gene of CDKN2B, CDKN2A, by recruiting polycomb repressive complex 2 (PRC2) which leads to histone methylation (H3K27me).
Por exemplo, o ANRIL, ademais da capacidade de inducir a metilación de ADN, pode tamén reprimir o xene veciño de CDKN2B, o CDKN2A, ao recrutar o complexo represivo polycomb 2 (PRC2), que causa a metilación de histonas (H3K27me).