The citizens expelled it in 1552, allying with France: this was unacceptable for Charles, who sent his general Gian Giacomo Medici to lay siege to it with a Florentine-Imperial army.
Os cidadáns expulsárona en 1552, aliándose con Francia: isto era inaceptable para o Emperador, que enviou ao seu xeneral Gian Giacomo Medici a asediala cun exército Florentino-Imperial.