Of these 16 cases, no cause was determined for 10, but 6 were found to have a heterozygous germline mutation in Pms2, followed by likely loss of heterozygosity in the tumor.
Destes 16 casos, non se determinou ningunha causa para 10 deles, pero en 6 atopouse unha mutación na liña xerminal heterocigota en Pms2, seguida da probable perda de heterocigose no tumor.