In 1989, Perrineau was cast as the original Tyrone Jackson in the world premiere of the stage adaptation of the 1980 hit movie Fame (now known as Fame: The Musical) at the Walnut Street Theatre, in Philadelphia, Pennsylvania.
En 1989, Perrineau foi elixido como o orixinal Tyrone Jackson na estrea mundial da adaptación teatral do filme de 1980, Fame (agora coñecido como Fame: The Musical) no Walnut Street Theatre, en Filadelfia, Pensilvania.