This theory, called the selective theory was not proven for next five decades, and had been challenged by several instructional theories which were based on the notion that an antibody would assume its effective structure by folding around the antigen.
Esta teoría, chamada "a teoría selectiva" non se conseguiu probar durante as seguintes cinco décadas, e fora desafiada por varias "teorías instrucionais" alternativas, que estaban baseadas na noción de que un anticorpo adopta a súa estrutura efectiva ao pregarse arredor do antíxeno.