One of these, HOTAIR, silences in trans (it is transcribed from the HOXC cluster and inhibits late HOXD genes) by binding to Polycomb-group proteins (PRC2).
Un destes, HOTAIR, silencia en trans (é transcrito no cluster HOXC e inhibe os últimos xenes HOXD) uníndose a proteínas do grupo Polycomb (PRC2).