In the recorded period, the region was home to the Potano, a Timucua chiefdom descended from Alachua culture people (the town of Potano was in what is now the San Felasco Hammock northwest of Gainesville).
No período descrito, a rexión foi o fogar dos Potano, un cacicado Timucua descendente da cultura Alachua (a cidade de Potano existiu no que hoxe é o San Felasco Hammock, ao noroeste de Gainesville) .