The increased rate of mutation during the SOS response is caused by three low-fidelity DNA polymerases: Pol II, Pol IV and Pol V. Researchers are now targeting these proteins with the aim of creating drugs that prevent SOS repair.
O incremento do grao de mutación durante a resposta SOS está causado por tres ADN polimerases de baixa fidelidade: Pol II, Pol IV e Pol V. Os investigadores están actualmente estudando estas proteínas para crear drogas que impidan a reparación SOS.