Comparisons are restricted to that part of the sequence directly involved in the reaction, which in the case of a peptidase must include the active site, and for a protein inhibitor the reactive site.
As comparacións están restrinxidas a esa parte da secuencia implicada directamente na reacción, o cal no caso das peptidases debe incluír o centro activo, e para un inhibidor proteico o sitio reactivo.