The polymerases responsible for polyadenylation were first purified and characterized in the 1960s and 1970s, but the large number of accessory proteins that control this process were discovered only in the early 1990s.
As polimerases responsables da poliadenilación foron purificadas e caracterizadas nas décadas de 1960 e 1970, pero o gran número de proteínas accesorias que controlan este proceso non se descubrirían ata a década de 1990.