These models were called into question during the late 1970s when data accumulated suggesting that mesosomes are artifacts formed through damage to the membrane during the process of chemical fixation, and do not occur in cells that have not been chemically fixed.
Estes modelos revisáronse a finais da década de 1970 cando os datos acumulados suxerían que os mesosomas eran artefactos debidos a danos na membrana durante o proceso de fixación química, e non están presentes nas células que non foron fixadas quimicamente.