The typical ligands for nuclear receptors are non-polar hormones like the steroid hormones testosterone and progesterone and derivatives of vitamins A and D. To initiate signal transduction, the ligand must pass through the plasma membrane by passive diffusion.
Os ligandos típicos dos receptores nucleares son hormonas lipofílicas como as hormonas esteroides testosterona e proxesterona e derivados das vitaminas A e D. Para iniciar a transdución de sinais, o ligando debe pasar a través da membrana plasmática por difusión pasiva.