In 1424 Carlo II and his sisters were adopted by their uncle Carlo I. Carlo II's sister Maddalena Tocco married the future Byzantine Emperor Constantine XI Palaiologos in 1428, but died in 1429.
En 1424 Carlo II e as súas irmás foron adoptados polo seu tío Carlo I. A irmá de Carlo II Maddalena Tocco casou co futuro emperador bizantino Constantino XI Paleólogo en 1428, pero morreu en 1429.