After initial successes and having conquered large parts of the territory of Milan, they were utterly defeated by a French army in the Battle of Marignano in 1515, which put an end to military territorial interventions of the confederation, mercenary services under the flags of foreign armies excepted.
Logo duns primeiros éxitos, e tras conquistar gran parte do territorio do Ducado de Milán, foron derrotados finalmente polo exército francés na Batalla de Marignano en 1515, o que puxo fin ás intervencións militares da confederación, exceptuando os servizos mercenarios baixo bandeiras estranxeiras.