However, on the other hand, p53, a well-known tumor suppressor, represses EMT by activating the expression of various microRNAs – miR-200 and miR-34 that inhibit the production of protein ZEB and SNAIL, and thus maintain the epithelial phenotype.
Porén, un supresor de tumores ben coñecido como p53 reprime a TEM ao activar a expresión de varios microARNs (miR-200 e miR-34 que inhiben a produción das proteínas ZEB e SNAIL), e así mantén o fenotipo epitelial.