The effects of IL-6 on depression are mediated through the repression of brain-derived neurotrophic factor (BDNF) expression in the brain; DNMT1 hypermethylates the BDNF promoter and reduces BDNF levels.
Os efectos da IL-6 sobre a depresión son mediados por medio da represión da expresión do factor neurotrófico derivado do cerebro (BDNF) no cerebro; a DNMT1 hipermetila o promotor do BDNF e reduce os niveis de BDNF.