Once a response against a dengue virus serotype has been established, it is unlikely that vaccination against a second will be effective, implying that balanced responses against all four virus serotypes have to be established with the first vaccine dose.
Unha vez que se establece unha resposta contra un serotipo do virus do dengue, é improbable que a vacinación contra un segundo serotipo sexa efectiva, o que implica que deben establecerse respostas equilibradas contra todos os serotipos do virus (hai catro) coa primeira dose de vacina.