The RAG-1 core contains three acidic residues (D600, D708, and E962) in what is called the DDE motif, the major active site for DNA cleavage.
O núcleo de RAG-1 contén tres residuos ácidos (D600, D708 e E962) no que se chama o motivo DDE, o sitio activo principal para a clivaxe do ADN.