During his graduate studies Wüthrich started out working with electron paramagnetic resonance spectroscopy, and the subject of his Ph.D. thesis was "the catalytic activity of copper compounds in autoxidation reactions".
Durantes os seus estudos de gradación Wüthrich comezou a traballar coa espectroscopia de resonancia paramagnética electrónica e o tema da súa tese Ph.D. foi "a actividade catalítica dos compostos de cobre nas reaccións de autooxidación".