One mechanism of diversification has been noted in the study of Amazonian tribes of South America that appear to have undergone intense gene conversion between variable alleles and loci within each HLA gene class.
Detectouse un mecanismo de diversificación no estudo das tribos amazónicas de América do Sur, as cales parece que sufriron unha intensa conversión xénica entre alelos variables e loci dentro de cada clase xénica HLA.