This has occurred in clinical trials for X-linked severe combined immunodeficiency (X-SCID) patients, in which hematopoietic stem cells were transduced with a corrective transgene using a retrovirus, and this led to the development of T cell leukemia in 3 of 20 patients.
Isto ocorreu en ensaios clínicos en pacientes con inmunodeficiencia combinada grave ligada ao X (X-SCID), na cal as células nais hematopoéticas foron transducidas cun transxene corrector usando un retrovirus, e isto levou ao desenvolvemento dunha leucemia de células T en 3 pacientes dun grupo de 20.