Spain made several attempts to conquer and colonize the area, notably including Tristán de Luna's short-lived settlement in 1559, but it was not settled permanently until the 17th century, with the establishment of missions to the Apalachee.
España fixo moitos intentos de conquistar e colonizar esa área, incluíndo o breve asentamento de 1559 de Tristán de Luna, pero sen lograr un asentamento permanente ata o século XVII, coa chegada das misións ao territorio dos apalaches.