The homeobox domain was first identified in a number of Drosophila homeotic and segmentation proteins, but is now known to be well-conserved in many other animals, including vertebrates.
O dominio homeobox foi identificado inicialmente en varias proteínas homeóticas e de segmentación de Drosophila, pero sábese que están ben conservados en moitos outros animais, incluíndo os vertebrados.