In 1958, Daniel Koshland suggested a modification to the lock and key model: since enzymes are rather flexible structures, the active site is continuously reshaped by interactions with the substrate as the substrate interacts with the enzyme.
En 1958, Daniel Koshland suxeriu unha modificación ao modelo de chave-pechadura: dado que os enzimas son estruturas flexibles, a forma do centro activo varía constantemente ao interaccionar co substrato.