In patients with glioblastoma, a severe type of brain tumor, the methylation state of the MGMT gene determined whether tumor cells would be responsive to temozolomide; if the promoter was methylated, temozolomide was more effective.
En pacientes con glioblastoma multiforme, un tipo grave de tumor cerebral, o estado de metilación do xene MGMT determina se as células tumorais responderán ao tratamento con temozolomida; se o promotor está metilado, a temozolomida é máis efectiva.