In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages.
En 1990 identificouse o oncoxene v-mpl a partir do virus da leucemia mieloproliferativa murina, que podía inmortalizar as células hematopoéticas da medula ósea de diferentes liñaxes.