Established evolutionary biologists—particularly Ernst Mayr, Theodosius Dobzhansky, and George Gaylord Simpson, three of the architects of the modern synthesis—were extremely skeptical of molecular approaches, especially when it came to the connection (or lack thereof) to natural selection.
Os biólogos evolutivos establecidos, especialmente Ernst Mayr, Theodosius Dobzhansky e George Gaylord Simpson, tres dos arquitectos da moderna síntese, eran extremadamente escépticos dos enfoques moleculares, especialmente cando se chegou á conexión (ou falta de conexión) coa selección natural.