The hypothesis that APP has ferroxidase activity in its E2 domain and facilitates export of Fe(II) is possibly incorrect since the proposed ferroxidase site of APP located in the E2 domain does not have ferroxidase activity.
A hipótese de que a APP ten unha actividade de ferroxidase no seu dominio E2 e facilita a exportación do Fe(II) é posiblemente incorrecta xa que o sitio ferroxidase proposto da APP localizado no dominio E2 en realidade non ten actividade de ferroxidase.