Negative signaling through SHIP appears to inhibit the Ras pathway through SH2 domain competition with Grb2 and Shc and may involve consumption of intracellular lipid mediators that act as allosteric enzyme activators or that promote entry of extracellular Ca2+.
A sinalización negativa a través de SHIP parece inhibir a vía Ras por competición do dominio SH2 con Grb2 e Shc e pode implicar o consumo de mediadores lipídicos intracelulares que actúan como activadores de encimas alostéricos ou que promoven a entrada de Ca2+ extracelular.