Subsequently, in 1975 Lloyd J. Old from Memorial Sloan-Kettering Cancer Center, New York, reported another cytotoxic factor produced by macrophages and named it tumor necrosis factor (TNF).
Posteriormente, en 1975, o Dr. Lloyd J. Old do Memorial Sloan-Kettering Cancer Center, de Nova York, informou sobre outros factores citotóxicos producidos polos macrófagos e usou a denominación factor de necrose tumoral (TNF).