A second important rapid regulator of glucokinase activity in beta cells occurs by direct protein-protein interaction between glucokinase and the "bifunctional enzyme" (phosphofructokinase-2/fructose-2,6-bisphosphatase), which also plays a role in the regulation of glycolysis.
Un segundo e importante regulador rápido da actividade da glicoquinase nas células beta é a interacción directa proteína-proteína entre a glicoquinase e o "encima bifuncional" (fosfofrutoquinase-2/frutosa-2,6-bisfosfatase), que tamén xoga un papel na regulación da glicólise.