The term "molecular chaperone" appeared first in the literature in 1978, and was invented by Ron Laskey to describe the ability of a nuclear protein called nucleoplasmin to prevent the aggregation of folded histone proteins with DNA during the assembly of nucleosomes.
O termo "chaperona molecular" apareceu por primeira vez na literatura científica en 1978, e foi acuñado por Ron Laskey para describir con el a capacidade dunha proteína nuclear chamada nucleoplasmina de impedir a agregación de proteínas histonas pregadas co ADN durante a ensamblaxe dos nucleosomas.