It has been discovered that this receptor has an antagonist in the form of A-317491, which, when present, has the ability to reduce both the evoked and unprompted firing of various classes of spinal neurons, as well as to inhibit release of IL-1β.
Descubriuse que este receptor ten o antagonista A-317491, que, se está presente, ten a capacidade de reducir tanto a descarga de impulsos evocada coma espontánea de varias clases de neuronas espiñais, e de inhibir a liberación de IL-1β.