In addition to the 6th Air Mobility Wing, which is "host wing" for the base, MacDill is also home to Headquarters, United States Central Command (USCENTCOM), Headquarters, United States Special Operations Command (USSOCOM), the 927th Air Refueling Wing, Headquarters, United States Marine Forces Central Command (USMARCENT), Headquarters, United States Special Operations Command Central (USSOCCENT), and numerous other military activities of the active and reserve components of the armed forces.
Ademais da 6º Á de Mobilidade Aérea, que é unha "á de acollida" para a base, MacDill alberga tamén o cuartel xeral do Comando Central dos Estados Unidos (USCENTCOM), do Comando de Operacións Especiais (USSOCOM), da 927º Á de Reabastecemento Aéreo, do Comando das Forzas Centrais da Mariña (USMARCENT), do Comando Central das Forzas Especiais (USSOCCENT), e de moitas outras actividades tanto dos compoñentes activos como de reserva das forzas armadas.