In 2002, the first comprehensive proofs of multiple classes of riboswitches were published, including protein-free binding assays, and metabolite-binding riboswitches were established as a new mechanism of gene regulation.
En 2002, publicáronse as primeiras probas exhaustivas da existencia de múltiples clases de riboswitches, incluíndo os ensaios de unión libres de proteínas, e quedou establecido que os riboswitches de unión a metabolitos eran un novo mecanismo de regulación xénica.