The INK4a/ARF family includes p16INK4a, which binds to CDK4 and arrests the cell cycle in G1 phase, and p14ARF which prevents p53 degradation.
A familia INK4a/ARF inclúe p16INK4a, cuxo produto se une a CDK4 e para o ciclo na fase G1, e p14arf, que impide a degradación de p53.