A few biologists however hung on to the idea of orthogenesis as late as the 1950s, claiming that the processes of macroevolution, the long term trends in evolution, were distinct from the processes of microevolution.
Porén, uns poucos biólogos permaneceron fieis á idea da ortoxénese ata a década de 1950, afirmando que o proceso da macroevolución, a tendencia a longo prazo da evolución sobre grandes taxons, era distinta do proceso da microevolución.