As enzymes have evolved to bind their substrates tightly, and most reversible inhibitors bind in the active site of enzymes, it is unsurprising that some of these inhibitors are strikingly similar in structure to the substrates of their targets.
Como os encimas evolucionaron para unirse aos seus substratos fortemente, e a maioría dos inhibidores reversibles se unen ao sitio activo dos encimas, é pouco sorprendente que algúns destes inhibidores sexan moi similares en estrutura aos substratos das súas dianas.