During Cd-induced malignant transformation, the promoter regions of ERCC1, as well as of hMSH2, XRCC1, and hOGG1, were heavily methylated and both the messenger RNA and proteins of these DNA repair genes were progressively reduced.
Durante a transformación maligna inducida polo Cd, as rexións promotoras de ERCC1, así como as de hMSH2, XRCC1 e hOGG1, estaban fortemente metiladas e tanto o ARNm coma as proteínas destes xenes de reparación do ADN estaban progresivamente reducidos.