Natili started in Formula One with Scuderia Centro Sud in 1961 with a retirement from the Syracuse Grand Prix, followed by a failure to qualify for the Naples Grand Prix.
Natili comezou na Fórmula Un coa Scuderia Centro Sud en 1961 cunha retirada do Gran Premio de Siracusa, seguido dun fracaso na cualificación no Gran Premio de Nápoles.