One of the two sons of Matthew Kantakouzenos, he disputed the succession to the Despotate of the Morea with Theodore I Palaiologos, the son of John V between 1380 and 1384.
Un dos dous fillos de Mateo Cantacuzeno disputou a sucesión do Despotado de Morea con Teodoro I Paleólogo, o fillo de Xoán V, entre 1380 e 1384.