The 757 was also flown out of airports with stringent noise regulations, such as John Wayne Airport in Orange County, California, and airports with aircraft size restrictions, such as Washington National Airport near downtown Washington, D.C. The largest U.S. operators, Delta Air Lines and American Airlines, would ultimately operate fleets of over 100 aircraft each.
O 757 tamén foi usado en aeroportos sen restricións de ruído, como o John Wayne de Orange County, California, e nos que tiñan limitacións de tamaño nos avións, como o Washington National Airport preto do centro de Washington, D.C. O maiores operadores estadounidenses, Delta Air Lines e American Airlines, finalmente operarían frotas duns 100 exemplares cada un.