This aggregation of DDR factors and concentration of phosphorylated and ubiquitinated histones is called a DNA damage foci or ionizing radiation-induced foci and the main role of MDC1 is to coordinate the creation of DNA damage foci.
Esta agregación de factores da DDR e a concentración de histonas fosforiladas e ubiquitinadas denomínase focos de danos no ADN ou focos inducidos por radiación ionizante e o principal papel da MDC1 é coordinar a creación destes focos de danos no ADN.