Several proteins such as SNAI1/SNAIL, ZFHX1B/SIP1, SNAI2/SLUG, TWIST1 and DeltaEF1 have been found to downregulate E-cadherin expression.
Varias proteínas como SNAI1/SNAIL, ZFHX1B/SIP1, SNAI2/SLUG, TWIST1 e DeltaEF1 regulan á baixa a expresión da E-cadherina.