There is only one well-studied example in which a class 1 virus is not replicating within the nucleus: the Poxvirus family, a highly pathogenic virus that infects vertebrates and includes the smallpox virus.
Só hai un exemplo ben estudado no cal un virus da clase I non se replica no núcleo, que é o da familia dos Poxvirus, uns virus moi patoxénicos que infectan vertebrados e inclúen o virus da varíola.