Selective ablation of PR-A in a mouse model, resulting in exclusive production of PR-B, unexpectedly revealed that PR-B contributes to, rather than inhibits, epithelial cell proliferation both in response to estrogen alone and in the presence of progesterone and estrogen.
A ablación selectiva do PR-A nun modelo de rato, resultando na produción exclusiva de PR-B, revelou inesperadamente que o PR-B contribúe a, no canto de inhibir, a proliferación de células epiteliais tanto en resposta a estróxenos sós e en presenza de proxesterona e estróxeno.