PI(4,5)P2 plays a large role in regulating the cell’s cytoskeleton, and disrupting PI(4,5)P2 causes many of the same results as this type of cholesterol depletion, including lateral diffusion of the proteins in the membrane.
O PI(4,5)P2 xoga un amplo papel na regulación do citoesqueleto da célula, e a alteración do PI(4,5)P2 causa moitos resultados similares aos da depleción do colesterol, incluíndo a difusión lateral de proteínas na membrana.