The severing of microtubules by katanin is regulated by nucleotide exchange factors, which can exchange ADP with ATP, protective microtubule-associated proteins (MAPs), and the p80 subunit (p60 severs microtubules much better in the presence of p80).
O corte dos microtúbulos que fai a katanina está regulado polo factor de intercambio de nucleótidos (que pode intercambiar ADP e ATP), e polas proteínas asociadas aos microtúbulos (MAPs), e a subunidade p80 (a p60 corta os microtúbulos moito mellor en presenza de p80).