Both characters play instruments (House plays the piano, the guitar, and the harmonica; Holmes, the violin) and take drugs (House is dependent on Vicodin; Holmes uses cocaine recreationally).
Os dous personaxes tocan instrumentos musicais (House o piano, a guitarra e a harmónica mentres que Holmes toca o violín) e toman drogas (House está adicto á Vicodina mentres que Holmes toma cocaína de forma recreativa).