Two direct sequels were released in 2001; one developed by Torus Games, Spider-Man 2: The Sinister Six, released for the Game Boy Color, and one developed by Vicarious Visions, Spider-Man 2: Enter Electro, released exclusively for the PlayStation.
Tivo dúas secuelas directas, unha desenvolvida por Torus Games, Spider-Man 2: The Sinister Six para Game Boy Color, e outra desenvolvida por Vicarious Visions, Spider-Man 2: Enter Electro para PlayStation.