Sahle-Work subsequently held other high level positions including as Permanent Representative of Ethiopia to the African Union and the United Nations Economic Commission for Africa (ECA) and as Director-General for African Affairs in the Ministry of Foreign Affairs of Ethiopia.
Sittemmin Sahle-Work on työskennellyt muissakin korkeissa viroissa, kuten Etiopian pysyvänä edustajana Afrikan unionissa ja ECA:ssa ja Etiopian ulkoasiainministeriön Afrikan asioiden pääjohtajana.