Discovery and development of NNRTIs began in the late 1980s and in the end of 2009 four NNRTI had been approved by regulatory authorities and several others were undergoing clinical development.
بدأ اكتشاف وتطوير ال NNRTIs في أواخر 1980م وفي نهاية عام 2009 أربعة أنواع من مثبطات ال NNRTI تمت الموافقة عليها من قبل السلطات الصحية.