Well known GEFs include Son of Sevenless (Sos) and cdc25 which include the RasGEF domain.
وبالتالي فإن GEF تسهل تفعيل رأس.  وتشمل GEFs المعروفة جيدا (Son of Sevenless) و cdc25 التي تتضمن نطاق RasGEF.