rudyvdbrink/CitationDatabase huggingface dataset:
Valproic acid exposure impairs ultrasonic communication in infant, adolescent and adult rats.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2020

Persistent deficits of social communication are a hallmark of autism spectrum disorders (ASD). Communication disabilities can be experimentally modeled using rodents' ultrasonic vocalizations (USVs). Although prenatal exposure to valproic acid (VPA) is one of the most widely used animal models of ASD, little is known about communication impairments in this model. We performed a longitudinal study to characterize VPA-induced socio-communicative deficits in male and female rats. USVs were recorded in neonatal rats during maternal separation, in adolescent rats during social play, and in adult rats during social interactions. VPA male and female pups emitted a reduced number of USVs. Their calls were shorter and of an elevated peak frequency. Although social play deficits in adolescent rats were restricted to males only, both males and females demonstrated quantitative and qualitative changes in USVs. Altered vocalization also accompanied deficient social interactions in adult VPA males. In contrast to the adolescents, however, these differences were limited to a reduced number of USVs, but not to the call's structure. Present data suggest that ultrasonic vocalization measurement is a useful tool in detecting lifelong communicative disability in a VPA exposure-induced ASD model. We postulate that USV assessment in female rats may be a more sensitive indicator of juvenile autistic-like disturbances than other behavioral measures.
Evaluation of the Effectiveness of a Novel Brain-Computer Interface Neuromodulative Intervention to Relieve Neuropathic Pain Following Spinal Cord Injury: Protocol for a Single-Case Experimental Design With Multiple Baselines.
JMIR research protocols, 2020

Neuropathic pain is a debilitating secondary condition for many individuals with spinal cord injury. Spinal cord injury neuropathic pain often is poorly responsive to existing pharmacological and nonpharmacological treatments. A growing body of evidence supports the potential for brain-computer interface systems to reduce spinal cord injury neuropathic pain via electroencephalographic neurofeedback. However, further studies are needed to provide more definitive evidence regarding the effectiveness of this intervention.
Neurological Examination Techniques of Speech in 
The Malaysian journal of medical sciences : MJMS, 2020

There are four classification levels for speech disorders namely dysphonia, dysarthria, dysprosody and dysphasia. In general, speech examination mainly focuses on three main components that are spontaneous speech, auditory comprehension, and oral motor examination. Quick bedside assessment on speech in
Development of a Patient Reported Measure of Experimental Transplants with HIV and Ethics in the United States (PROMETHEUS).
Journal of patient-reported outcomes, 2021

Transplantation of HIV-positive (HIV+) donor organs for HIV+ recipients (HIV D+/R+) is now being performed as research in the United States, but raises ethical concerns. While patient-reported outcome measures are increasingly used to evaluate clinical interventions, there is no published measure to aptly capture patients' experiences in the unique context of experimental HIV D+/R+ transplantation. Therefore, we developed PROMETHEUS (patient-reported measure of experimental transplants with HIV and ethics in the United States). To do so, we created a conceptual framework, drafted a pilot battery using existing and new measures related to this context, and refined it based on cognitive and pilot testing. PROMETHEUS was administered 6-months post-transplant in a clinical trial evaluating these transplants. We analyzed data from the first 20 patient-participants for reliability and validity by calculating Cronbach's alpha and reviewing item performance characteristics.
The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel.
Nature communications, 2018

The capsaicin receptor TRPV1 has been intensively studied by cryo-electron microscopy and functional tests. However, though the apo and capsaicin-bound structural models are available, the dynamic process of capsaicin activation remains intangible, largely due to the lack of a capsaicin-induced open structural model and the low occupancy of the transition states. Here we report that reducing temperature toward the freezing point substantially increased channel closure events even in the presence of saturating capsaicin. We further used a combination of fluorescent unnatural amino acid (fUAA) incorporation, computational modeling, and rate-equilibrium linear free-energy relationships analysis (Φ-analysis) to derive the fully open capsaicin-bound state model, and reveal how the channel transits from the apo to the open state. We observed that capsaicin initiates a conformational wave that propagates through the S4-S5 linker towards the S6 bundle and finally reaching the selectivity filter. Our study provides a temporal mechanism for capsaicin activation of TRPV1.
The Neurological Exam of a Comatose Patient: An Essential Practical Guide.
The Malaysian journal of medical sciences : MJMS, 2020

A thorough examination of a comatose patient is essential given the spectrum of clinical diagnoses. The most immediate threat to patients is airway, breathing and circulation. All attending physician should employ a structured and focused approach in dealing with a comatose patient. It is important to recognise the urgent steps needed at the time to prevent further deterioration, followed by the final diagnosis of patient's neurologic status. Here we provide the essential practical guide to the neurological exam of a comatose patient that would assist to determine the aetiology, location and nature of the neurological lesion.
Document-Engineering Methodology in Health Care: An Innovative Behavioral Science-Based Approach to Improve Patient Empowerment.
JMIR human factors, 2020

Engaging patients in their treatment and making them experts of their condition has been identified as a high priority across many medical disciplines. Patient empowerment claims to improve compliance, patient safety, and disease outcome. Patient empowerment may help the patient in shared decision making and in becoming an informed partner of the health care professional. We consider patient empowerment to be in jeopardy if written medical information for patients is too complex and confusing. We introduce document-engineering methodology (DEM) as a new tool for the health care industry. DEM tries to implement principles of cognitive science and neuroscience-based concepts of reading and comprehension. It follows the most recent document design techniques. DEM has been used in the aviation, mining, and oil industries. In these very industries, DEM was integrated to improve user performance, prevent harm, and increase safety. We postulate that DEM, applied to written documents in health care, will help patients to quickly navigate through complex written information and thereby enable them to better comprehend the essence of the medical information. DEM aims to empower the patient and help start an informed conversation with their health care professional. The ultimate goals of DEM are to increase adherence and compliance, leading to improved outcomes. Our approach is innovative, as we apply our learning from other industries to health care; we call this cross-industry innovation. In this manuscript, we provide illustrative examples of DEM in three frequent clinical scenarios: (1) explaining a complex diagnosis for the first time, (2) understanding medical leaflet information, and (3) exploring cannabis-based medicine. There is an urgent need to test DEM in larger clinical cohorts and for careful proof-of-concept studies, regarding patient and stakeholder engagement, to be conducted.
An experimental study on spontaneous recovery of conditioned reward expectancies and instrumental responding in humans.
Behaviour research and therapy, 2019

The aim of the present study was to investigate spontaneous recovery of reward-expectancies and a reward-associated response in humans and to assess individual factors affecting spontaneous recovery. We therefore implemented an experimental procedure comprising three separate test-sessions. In the first test-session, participants underwent instrumental discrimination training to acquire a conditioned reward-associated response, in the second test-session, memory of this response was tested followed by extinction training. In the third test-session, extinction memory was assessed. Our results demonstrate spontaneous recovery of extinguished conditioned reward-associated expectancies and indicate that differential expectancies after training and extinction and impulsivity significantly predicted the magnitude of spontaneous recovery. In contrast, limited evidence for spontaneous recovery of instrumental responding was found. Given that reward-expectancies might trigger instrumental responding these findings underline the importance of developing extinction procedures that lead to more complete and less fragile long-term extinction of reward-associated responses.
3-M Syndrome: A Local Case Report.
The American journal of case reports, 2019

BACKGROUND 3-M syndrome is an uncommon disease characterized by severe growth retardation, dysmorphic features, and skeletal abnormalities. Radiographic images may show delayed bone maturation long slender tubular bones, and tall vertebral bodies. Due to the inheritance mode of 3-M syndrome disease, early diagnosis is vital for genetic counseling. CASE REPORT In this case report, we present the case of a 3-year-old male patient who was referred to our clinic for development assessment due to delayed development, particularly speech, who had clinical outcomes of 3-M syndrome. CONCLUSIONS The aim of the case report is to add this new patient to the literature on 3-M syndrome.
Synesthesia does not help to recover perceptual dominance following flash suppression.
Scientific reports, 2021

Grapheme-colour synesthesia occurs when letters or numbers elicit an abnormal colour sensation (e.g., printed black letters are perceived as coloured). This phenomenon is typically reported following explicit presentation of graphemes. Very few studies have investigated colour sensations in synesthesia in the absence of visual awareness. We took advantage of the dichoptic flash suppression paradigm to temporarily render a stimulus presented to one eye invisible. Synesthetic alphanumeric and non-synesthetic stimuli were presented to 21 participants (11 synesthetes) in achromatic and chromatic experimental conditions. The test stimulus was first displayed to one eye and then masked by a sudden presentation of visual noise in the other eye (flash suppression). The time for an image to be re-perceived following the onset of the suppressive noise was calculated. Trials where there was no flash suppression performed but instead mimicked the perceptual suppression of the flash were also tested. Results showed that target detection by synesthetes was significantly better than by controls in the absence of flash suppression. No difference was found between the groups in the flash suppression condition. Our findings suggest that synesthesia is associated with enhanced perception for overt recognition, but does not provide an advantage in recovering from a perceptual suppression. Further studies are needed to investigate synesthesia in relation to visual awareness.
Double diffusion encoding and applications for biomedical imaging.
Journal of neuroscience methods, 2021

Diffusion Magnetic Resonance Imaging (dMRI) is one of the most important contemporary non-invasive modalities for probing tissue structure at the microscopic scale. The majority of dMRI techniques employ standard single diffusion encoding (SDE) measurements, covering different sequence parameter ranges depending on the complexity of the method. Although many signal representations and biophysical models have been proposed for SDE data, they are intrinsically limited by a lack of specificity. Advanced dMRI methods have been proposed to provide additional microstructural information beyond what can be inferred from SDE. These enhanced contrasts can play important roles in characterizing biological tissues, for instance upon diseases (e.g. neurodegenerative, cancer, stroke), aging, learning, and development. In this review we focus on double diffusion encoding (DDE), which stands out among other advanced acquisitions for its versatility, ability to probe more specific diffusion correlations, and feasibility for preclinical and clinical applications. Various DDE methodologies have been employed to probe compartment sizes (Section 3), decouple the effects of microscopic diffusion anisotropy from orientation dispersion (Section 4), probe displacement correlations, study exchange, or suppress fast diffusing compartments (Section 6). DDE measurements can also be used to improve the robustness of biophysical models (Section 5) and study intra-cellular diffusion via magnetic resonance spectroscopy of metabolites (Section 7). This review discusses all these topics as well as important practical aspects related to the implementation and contrast in preclinical and clinical settings (Section 9) and aims to provide the readers a guide for deciding on the right DDE acquisition for their specific application.
Stages of Change Readiness and Treatment Eagerness Scale in Overweight and Obesity's Psychometric Properties (SOCRATES-OO).
Journal of clinical psychology in medical settings, 2020

The present study investigated the psychometric properties of the Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES) in the context of overweight and obesity. The instrument was investigated in a non-probabilistic sample of 177 individuals who were overweight or obese. A confirmatory factor analysis (CFA) was performed in order to provide evidence based on the internal consistency of the SOCRATES-OO scale with three correlated factors and two correlated factors. In addition, the University of Rhode Island Change Assessment (URICA) raw score was used to provide evidence in terms of convergent validity by its correlation with the domains of the best SOCRATES-OO solution. According to CFA, the theoretical solution with two correlated factors provided a better statistical fit. The psychometric evaluation of the 19 items of SOCRATES-OO presented a good fit under the two-factor model and satisfactory internal consistency by Omega of AMREC (Ambivalence + Recognition) 0.924 and Action 0.942.
The MRI Self-Efficacy Scale for Children: Development and Preliminary Psychometrics.
Journal of pediatric psychology, 2020

Magnetic resonance imaging (MRI) is a common procedure that can be distressing for children. Although not yet studied in the context of pediatric medical procedures, self-efficacy may be a good predictor of procedural stress and a clinically feasible target for behavioral intervention. The objectives of this study were to develop the MRI Self-Efficacy Scale for Children (MRI-SEC) and assess the preliminary psychometric properties.
The FGIN period: electrophysiological studies.
Pharmacological research, 2011

This historical review of the electrophysiology laboratory complemented the activity of the various research teams at the Fidia Georgetown Institute for the Neurosciences and it was the fulfillment of Dr. Erminio Costa's dream to be able to study the inhibitory and excitatory synapse in the central nervous system. These studies were facilitated by the development of the patch clamp technique that allows the functional testing of several of the biochemical and pharmacological hypotheses. The studies described here were the results of the hard work of all the collaborators involved in the projects that will never forget the passionate and stimulating discussion with Dr Costa during and after the development of these projects.
Clinical utility of home videos for diagnosing epileptic seizures: a systematic review and practical recommendations for optimal and safe recording.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021

The aim of the present systematic revision is to analyze existing published reports about the use of home-videos recordings (HVRs) to support physicians in the differential diagnosis of paroxysmal seizure-like episodes (PSLE). We also developed practical recommendations in order to ensure adequate quality standards and safety advice for HVRs.
Stimulus valence, episodic memory, and the priming of brain activation profiles in borderline personality disorder.
Psychological medicine, 2021

Borderline personality disorder (BPD) is characterized by instability in affective regulation that can result in a loss of cognitive control. Triggers may be neuronal responses to emotionally valenced context and/or stimuli. 'Neuronal priming' indexes the familiarity of stimuli, and may capture the obligatory effects of affective valence on the brain's processing system, and how such valence mediates responses to the repeated presentation of stimuli. We investigated the effects of affective valence of stimuli on neuronal priming (i.e. changes in activation to repeated presentation of stimuli), and if these effects distinguished BPD patients from controls.
The impact of maintenance therapy on sleep-wake rhythms and cancer-related fatigue in pediatric acute lymphoblastic leukemia.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020

To assess the impact of maintenance therapy and the additional impact of dexamethasone treatment on cancer-related fatigue and sleep-wake rhythms in pediatric acute lymphoblastic leukemia (ALL) patients and to determine the association between these outcomes.
Practice Habits, Knowledge, and Attitudes of Hepatologists to Alcohol Use Disorder Medication: Sobering Gaps and Opportunities.
Transplantation direct, 2020

The prevalence of alcohol use disorder (AUD) and alcohol-associated liver disease is increasing in the United States. Efficacious AUD pharmacotherapies, while available, are, for protean reasons, underutilized. Hepatology providers may be in a position to bridge the pharmacotherapeutic gap between availability and utilization of AUD pharmacotherapies. Our aim was to ascertain the current practice, knowledge and attitudes of hepatology physicians in the United States, and identify opportunities on how to increase AUD medication prescribing.
Latin American consensus recommendations for management and treatment of neuromyelitis optica spectrum disorders in clinical practice.
Multiple sclerosis and related disorders, 2020

During the last two decades, neuromyelitis optica spectrum disorder (NMOSD) has undergone important changes, with new diagnostic markers and criteria, better recognition of clinical phenotypes, better disease prognosis and new therapeutic approaches. Consequently, management of NMOSD patients in Latin American (LATAM) has become more complex and challenging in clinical practice. In making these consensus recommendations, the aim was to review how the disease should be managed and treated among LATAM patients, in order to improve long-term outcomes in these populations.
Unusual clear cell, lymphoplasmacyte-rich, dural-based tumor with divergent differentiation: a tricky case mimicking a meningioma.
Human pathology, 2015

We describe an unusual case of a recurrent dural neoplasm, previously diagnosed as meningioma. Histopathologically, the tumor is characterized by aggregates of divergently differentiated clear cells embedded in an abundant lymphoplasmacyte-rich stroma, mimicking a lymphoplasmacyte-rich meningioma. This study focuses on the histologic and immunohistochemical characterization of a unique dural-based tumor and provides useful guidelines for differentiating meningioma from other uncommon dural-based neoplasms. We propose that this recurrent dural neoplasm is a distinctive entity and, therefore, enlarges the spectrum of dural-based neoplasms that enter the differential diagnosis with meningiomas. Awareness of this tumor entity could prove useful for appropriate patient management.
Creutzfeldt-Jakob disease surveillance in Australia: update to December 2015.
Communicable diseases intelligence quarterly report, 2016

Nation-wide surveillance of human transmissible spongiform encephalopathies (also known as prion diseases), the most common being Creutzfeldt-Jakob disease, is performed by the Australian National Creutzfeldt-Jakob Disease Registry, based at the University of Melbourne. Prospective surveillance has been undertaken since 1993 and over this dynamic period in transmissible spongiform encephalopathy research and understanding, the unit has evolved and adapted to changes in surveillance practices and requirements concomitant with the delineation of new disease subtypes, improvements in diagnostic capabilities and the overall heightened awareness of prion diseases in the health care setting. In 2015, routine national surveillance continued and this brief report provides an update of the cumulative surveillance data collected by the Australian National Creutzfeldt-Jakob Disease Registry prospectively from 1993 to December 2015, and retrospectively to 1970.
Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study.
The lancet. Psychiatry, 2020

Concerns regarding potential neurological complications of COVID-19 are being increasingly reported, primarily in small series. Larger studies have been limited by both geography and specialty. Comprehensive characterisation of clinical syndromes is crucial to allow rational selection and evaluation of potential therapies. The aim of this study was to investigate the breadth of complications of COVID-19 across the UK that affected the brain.
The utility of an automated and ambulatory device for detecting and differentiating epileptic and psychogenic non-epileptic seizures.
Epilepsia open, 2019

Accurate differentiation between epileptic seizures (ES) and psychogenic non-epileptic seizures (PNES) can be challenging based on history alone. Inpatient video EEG monitoring (VEM) is often needed for a definitive diagnosis. However, VEM is highly resource intensive, is of limited availability, and cannot be undertaken over long periods. Previous research has shown that time-frequency analysis of accelerometer data could be utilized to differentiate between ES and PNES. Using a seizure detection and classification algorithm, we sought to examine the diagnostic utility of an automated analysis with an ambulatory accelerometer.
Insect Vision: Novel Mechanism for Contrast Constancy in Dim Light.
Current biology : CB, 2020

A general problem of sensory systems is how to simultaneously encode prevailing input as well as deviations from this baseline. A new study shows how the fly visual system has solved this by using parallel processing.