rudyvdbrink/CitationDatabase huggingface dataset:
Dysfunctional effort-based decision-making underlies apathy in genetic cerebral small vessel disease.
Brain : a journal of neurology, 2018

Apathy is a syndrome of reduced motivation that commonly occurs in patients with cerebral small vessel disease, including those with the early onset form, CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). The cognitive mechanisms underlying apathy are poorly understood and treatment options are limited. We hypothesized that disrupted effort-based decision-making, the cognitive process by which potential rewards and the effort cost required to obtain them is integrated to drive behaviour, might underlie the apathetic syndrome. Nineteen patients with a genetic diagnosis of CADASIL, as a model of 'pure' vascular cognitive impairment, and 19 matched controls were assessed using two different behavioural paradigms and MRI. On a decision-making task, participants decided whether to accept or reject sequential offers of monetary reward in return for exerting physical effort via handheld dynamometers. Six levels of reward and six levels of effort were manipulated independently so offers spanned the full range of possible combinations. Choice, decision time and force metrics were recorded. Each participant's effort and reward sensitivity was estimated using a computational model of choice. On a separate eye movement paradigm, physiological reward sensitivity was indexed by measuring pupillary dilatation to increasing monetary incentives. This metric was related to apathy status and compared to the behavioural metric of reward sensitivity on the decision-making task. Finally, high quality diffusion imaging and tract-based spatial statistics were used to determine whether tracts linking brain regions implicated in effort-based decision-making were disrupted in apathetic patients. Overall, apathetic patients with CADASIL rejected significantly more offers on the decision-making task, due to reduced reward sensitivity rather than effort hypersensitivity. Apathy was also associated with blunted pupillary responses to incentives. Furthermore, these independent behavioural and physiological markers of reward sensitivity were significantly correlated. Non-apathetic patients with CADASIL did not differ from controls on either task, whilst actual motor performance of apathetic patients in both tasks was also normal. Apathy was specifically associated with reduced fractional anisotropy within tracts connecting regions previously associated with effort-based decision-making. These findings demonstrate behavioural, physiological and anatomical evidence that dysfunctional effort-based decision-making underlies apathy in patients with CADASIL, a model disorder for sporadic small vessel disease. Reduced incentivization by rewards rather than hypersensitivity to effort costs drives this altered pattern of behaviour. The study provides empirical evidence of a cognitive mechanism for apathy in cerebral small vessel disease, and identifies a promising therapeutic target for interventions to improve this debilitating condition.
The Language Experience and Proficiency Questionnaire (LEAP-Q): Ten years later.
Bilingualism (Cambridge, England), 2020

The Language Experience and Proficiency Questionnaire (LEAP-Q) is a validated questionnaire tool for collecting self-reported proficiency and experience data from bilingual and multilingual speakers ages 14 to 80. It is available in over 20 languages, and can be administered in a digital, paper-and-pencil, and oral interview format. The LEAP-Q is used by researchers across various disciplines (Psychology, Neuroscience, Linguistics, Education, Communication Sciences & Disorders, etc.) to provide a comprehensive description of their bilingual participants, to substantiate a division of bilinguals into groups (e.g., early vs. late bilinguals), and to screen participants for adequate or threshold levels of language proficiency. Best practices for using the LEAP-Q include administration of the full questionnaire, consideration of acquisition and history of language use together with self-ratings of proficiency, and supplementation of self-reported data with objective language measures whenever possible. The LEAP-Q can be downloaded at no cost at https://bilingualism.northwestern.edu/leapq/.
Inhibitory control of active expiration by the Bötzinger complex in rats.
The Journal of physiology, 2020

Contraction of abdominal muscles at the end of expiration during metabolic challenges (such as hypercapnia and hypoxia) improves pulmonary ventilation. The emergence of this active expiratory pattern requires the recruitment of the expiratory oscillator located on the ventral surface of the medulla oblongata. Here we show that an inhibitory circuitry located in the Bötzinger complex is an important source of inhibitory drive to the expiratory oscillator. This circuitry, mediated by GABAergic and glycinergic synapses, provides expiratory inhibition that restrains the expiratory oscillator under resting condition and regulates the formation of abdominal expiratory activity during active expiration. By combining experimental and modelling approaches, we propose the organization and connections within the respiratory network that control the changes in the breathing pattern associated with elevated metabolic demand.
Sexual dimorphism of detrusor function demonstrated by urodynamic studies in rhesus macaques.
Scientific reports, 2020

The lower urinary tract (LUT) and micturition reflexes are sexually dimorphic across mammals. Sex as a biological variable is also of critical importance for the development and translation of new medical treatments and therapeutics interventions affecting pelvic organs, including the LUT. However, studies of LUT function with comparisons between the sexes have remained sparse, especially for larger mammals. Detrusor function was investigated by filling cystometry and pressure flow studies in 16 male and 22 female rhesus macaques. By filling cystometry, male subjects exhibited a significantly larger bladder capacity and compliance compared to females. Pressure flow studies showed a significantly higher bladder pressure at voiding onset, peak pressure, and elevation in detrusor-activated bladder pressure from the end of bladder filling to peak pressure in the male subjects. The activation of reflex micturition, with associated detrusor contractions, resulted in voiding in a significantly larger proportion of female compared to male subjects. A higher urethral outlet resistance is suggested in the male subjects. We conclude that sexual dimorphism of detrusor function is prominent in rhesus macaques, shares many features with the human, and merits consideration in translational and pre-clinical research studies of micturition and LUT function in non-human primates.
Assessing the Severity of Traumatic Brain Injury-Time for a Change?
Journal of clinical medicine, 2021

Traumatic brain injury (TBI) has been described to be man's most complex disease, in man's most complex organ. Despite this vast complexity, variability, and individuality, we still classify the severity of TBI based on non-specific, often unreliable, and pathophysiologically poorly understood measures. Current classifications are primarily based on clinical evaluations, which are non-specific and poorly predictive of long-term disability. Brain imaging results have also been used, yet there are multiple ways of doing brain imaging, at different timepoints in this very dynamic injury. Severity itself is a vague concept. All prediction models based on combining variables that can be assessed during the acute phase have reached only modest predictive values for later outcome. Yet, these early labels of severity often determine how the patient is treated by the healthcare system at large. This opinion paper examines the problems and provides caveats regarding the use of current severity labels and the many practical and scientific issues that arise from doing so. The objective of this paper is to show the causes and consequences of current practice and propose a new approach based on risk classification. A new approach based on multimodal quantifiable data (including imaging and biomarkers) and risk-labels would be of benefit both for the patients and for TBI clinical research and should be a priority for international efforts in the field.
Editorial: The role of digital technology in children and young people's mental health - a triple-edged sword?
Journal of child psychology and psychiatry, and allied disciplines, 2020

The rapid expansion of access to, and engagement with, the Internet and digital technology over the past 15 or so years has transformed the social, educational and therapeutic space occupied by children and young people in contemporary society in remarkable ways. First, it has created previously unimaginable opportunities for learning and development and personal exploration and growth. Second, it seems that the very same qualities and characteristics of the Internet that make these positive contributions possible, such as its immediacy, portability, intimacy, unconstrained reach and lack of supervision and regulation of content, has opened children and young people up to a range of serious social, intellectual and mental health risks. Finally, over and above these 'effects', the digital space is increasingly successfully being harnessed for the identification and treatment of mental health problems. Accordingly, the Internet is not so much a double-, as a triple-edged sword, with regard to children's mental health.
Teaching engineering ethics by conceptual design: the somatic marker hypothesis.
Science and engineering ethics, 2009

In 1998, a lead researcher at a Midwestern university submitted as his own a document that had 64 instances of strings of 10 or more words that were identical to a consultant's masters thesis and replicated a data chart, all of whose 16 entries were identical to three and four significant figures. He was fired because his actions were wrong. Curiously, he was completely unable to see that his actions were wrong. This phenomenon is discussed in light of recent advances in neuroscience and used to argue for a change in the standard way engineering ethics is taught. I argue that engineering ethics is better taught in the form of a design course in order to maximize "somatic" learning.
Ultrasound-Guided Anterior Mediastinotomy: A Feasible Tool for Critical Lymphoma Patients.
Healthcare (Basel, Switzerland), 2021

A significant part of all neoplasms growing in anterior mediastinum are lymphomas (25%). Achieving a correct diagnosis and a clear definition of a lymphoma's subtype is crucial for beginning chemotherapy as soon as possible. However, most patients present a large mediastinal mass that compresses vessels and airway, with serious cardiorespiratory repercussions. Therefore, having multiple tools available to biopsy the lesion without worsening morbidity becomes fundamental. Patients enrolled in this study were unfit for a surgical biopsy in general anesthesia and the need to begin chemotherapy as fast as possible prompted us to avoid percutaneous fine needle aspiration to prevent diagnostic failures. Our observational study included 13 consecutive patients with radiological findings of anterior mediastinal mass. Ultrasonography was performed directly in the theatre to mark the lesion and to localize vessels and vascularized neoplastic tissue. Open biopsy was carried out in spontaneous breathing with a laryngeal mask and with short-acting medications for a rapid anesthesia, performing an anterior mediastinotomy. The mean operative time was 33.4 ± 6.2 min and spontaneous respiration was maintained throughout the procedure. No complications were reported. All patients were discharged in the first or second postoperative day after a chest X-ray (1.38 ± 0.5 days). The diagnostic yield of this approach was 100%. With the addition of ultrasonography right before the procedure and with spontaneous breathing, anterior mediastinotomy still represents a useful tool in critical patients that could hardly tolerate a general anesthesia. The diagnostic yield is high, and the low postoperative morbidity allows a rapid onset of chemotherapy.
Physical fitness and white matter microstructure in children with overweight or obesity: the ActiveBrains project.
Scientific reports, 2020

Recent studies investigated the association of cardiorespiratory fitness with white matter microstructure in children, yet little work has explored to what extent other components of physical fitness (i.e., muscular or motor fitness) are associated with white matter microstructure. Indeed, this association has not been previously explored in children with overweight/obesity who present a different white matter development. Therefore, we aimed to examine associations between physical fitness components and white matter microstructure in children with overweight/obesity. In total, 104 (10.04 ± 1.15 years old; 43 girls) children were included in this cross-sectional study. Physical fitness was assessed using the ALPHA-fitness test battery. Fractional anisotropy (FA) and mean diffusivity were derived from diffusion tensor imaging (DTI). No association was found between physical fitness and global DTI metrics (all P > 0.082). Within individual tracts, all associations became non-significant when analyses were adjusted for multiple comparisons. Using the voxel-wise approach, we identified a small cluster in the left lateral frontal lobe where children with greater upper-body muscular fitness showed higher FA (P
Ideal observer analysis for task normalization of pattern classifier performance applied to EEG and fMRI data.
Journal of the Optical Society of America. A, Optics, image science, and vision, 2010

The application of multivariate techniques to neuroimaging and electrophysiological data has greatly enhanced the ability to detect where, when, and how functional neural information is processed during a variety of behavioral tasks. With the extension to single-trial analysis, neuroscientists are able to relate brain states to perceptual, cognitive, and motor processes. Using pattern classification methods, the neuroscientist can extract neural performance measures in a manner analogous to human behavioral performance, allowing for a consistent information content metric across measurement modalities. However, as with behavioral psychophysical performance, pattern classifier performances are a product of both the task-relevant information inherent in the brain and in the task/stimuli. Here, we argue for the use of an ideal observer framework with which the researcher can effectively normalize the observed neural performance given the task's inherent objective difficulty. We use data from a face versus car discrimination task and compare classifier performance applied to electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) data with corresponding human behavior through the absolute and relative efficiency metrics. We show that confounding variables that can lead to erroneous interpretations of information content can be accounted for through comparisons to an ideal observer, allowing for more confident interpretation of the neural mechanisms involved in the task of interest. Finally, we discuss limitations of interpretation due to the transduction of indirect measures of neural activity, underlying assumptions in the optimality of the pattern classifiers, and dependence of efficiency results on signal contrast.
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.
Science (New York, N.Y.), 2020

Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern Toll-like receptor 3 (TLR3)- and interferon regulatory factor 7 (IRF7)-dependent type I interferon (IFN) immunity to influenza virus in 659 patients with life-threatening COVID-19 pneumonia relative to 534 subjects with asymptomatic or benign infection. By testing these and other rare variants at these 13 loci, we experimentally defined LOF variants underlying autosomal-recessive or autosomal-dominant deficiencies in 23 patients (3.5%) 17 to 77 years of age. We show that human fibroblasts with mutations affecting this circuit are vulnerable to SARS-CoV-2. Inborn errors of TLR3- and IRF7-dependent type I IFN immunity can underlie life-threatening COVID-19 pneumonia in patients with no prior severe infection.
Temporal embedding and spatiotemporal feature selection boost multi-voxel pattern analysis decoding accuracy.
Journal of neuroscience methods, 2020

In fMRI decoding, temporal embedding of spatial features of the brain allows the incorporation of brain activity dynamics into the multivariate pattern classification process, and provides enriched information about stimulus-specific response patterns and potentially improved prediction accuracy.
Visual Neuroscience: Seeing Causality with the Motor System?
Current biology : CB, 2016

Understanding how humans perceive cause and effect in visual events has long intrigued philosophers and scientists. A new study in primates reveals the neural correlates of perceived causality at the single-cell level, but in an unexpected place - the motor system.
Retinal Vascular Features in Ocular Blunt Trauma by Optical Coherence Tomography Angiography.
Journal of clinical medicine, 2020

In this prospective study, we analysed the changes in retinal vessel density (VD) using optical coherence tomography angiography (OCTA) in patients with commotio retinae up to 6 months after blunt ocular trauma. We analysed the VD in the superficial capillary plexus (SCP), deep capillary plexus (DCP), radial peripapillary capillary (RPC) and the foveal avascular zone (FAZ) area at 48 h, and 1, 3 and 6 months after the trauma and compared results with those of healthy fellow eyes. We also evaluated the best-corrected visual acuity (BCVA) and the structural, spectral domain (SD)-OCT parameters: ganglion cell complex (GCC) and retinal nerve fibre layer (RNFL). A total of 18 eyes of 18 patients (8 males, 10 females, mean age 49.61 ± 9.2 years) and 18 healthy control eyes were evaluated. GCC and RNFL thicknesses showed a significant trend towards progressively lower values from 1 month and 3 months after the trauma, respectively, compared to healthy eyes (
Dual processes in memory: Evidence from memory of time-of-occurrence of events.
The Behavioral and brain sciences, 2020

Bastin et al. present a framework that draws heavily on existing ideas of dual processes in memory in order to make predictions about memory deficits in clinical populations. It has been difficult to find behavioral evidence for multiple memory processes but we offer some evidence for dual processes in a related domain: memory for the time-of-occurrence of events.
Genetic architecture of Alzheimer's disease.
Neurobiology of disease, 2020

Advances in genetic and genomic technologies over the last thirty years have greatly enhanced our knowledge concerning the genetic architecture of Alzheimer's disease (AD). Several genes including APP, PSEN1, PSEN2, and APOE have been shown to exhibit large effects on disease susceptibility, with the remaining risk loci having much smaller effects on AD risk. Notably, common genetic variants impacting AD are not randomly distributed across the genome. Instead, these variants are enriched within regulatory elements active in human myeloid cells, and to a lesser extent liver cells, implicating these cell and tissue types as critical to disease etiology. Integrative approaches are emerging as highly effective for identifying the specific target genes through which AD risk variants act and will likely yield important insights related to potential therapeutic targets in the coming years. In the future, additional consideration of sex- and ethnicity-specific contributions to risk as well as the contribution of complex gene-gene and gene-environment interactions will likely be necessary to further improve our understanding of AD genetic architecture.
In DA Club of Reinforcement: Glutamate, It's Your Birthday.
Neuron, 2020

Dopamine release guides reward encoding, but the contribution of glutamate remains unclear. In this issue of Neuron, Zell et al. leverage the genetic ablation of dopamine synthesis from midbrain VGluT2 neurons to assess how glutamate shapes positive reinforcement.
Photocontrol of Endogenous Glycine Receptors In Vivo.
Cell chemical biology, 2020

Glycine receptors (GlyRs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. Here we have developed Glyght, a GlyR ligand controlled with light. It is selective over other Cys-loop receptors, is active in vivo, and displays an allosteric mechanism of action. The photomanipulation of glycinergic neurotransmission opens new avenues to understanding inhibitory circuits in intact animals and to developing drug-based phototherapies.
The Transitive-Unaccusative Alternation: A Cross-Modal Priming Study.
Journal of psycholinguistic research, 2016

The relationship between different linguistic manifestations of an eventuality-denoting concept, referred to in the literature as diatheses or voices, is well-studied in theoretical linguistics. Among researchers studying this phenomenon, it is widely agreed that there is a systematic relationship between the various diatheses of a concept. However, when a specific alternation is addressed, the nature of this relationship, namely, its directionality, is at debate. This research employs the much-debated transitive-unaccusative alternation as a case-study and reports the results of two cross-modal priming experiments designed to explore how Hebrew speakers perceive it. The results reveal an asymmetry between the facilitating effects of transitives and unaccusatives, thus suggesting that the relationship between these diatheses is directional. As a whole, this study demonstrates that theoretical debates regarding derivational relationships can be addressed by means of psycholinguistic research.
Circuits for Raiders.
Neuron, 2018

Heindorf et al. (2018) report that motor cortex plays a key role in behavioral tasks that rely on continuous sensory feedback. They propose a layer-based circuit that might be of particular importance when coping with unexpected perturbations in dynamic environments.
Ring trial of 2nd generation RT-QuIC diagnostic tests for sporadic CJD.
Annals of clinical and translational neurology, 2020

Real-time quaking-induced conversion (RT-QuIC) assays detect prion-seeding activity in a variety of human biospecimens, including cerebrospinal fluid and olfactory mucosa swabs. The assay has shown high diagnostic accuracy in patients with prion disorders. Recently, advances in these tests have led to markedly improved diagnostic sensitivity and reduced assay times. Accordingly, an algorithm has been proposed that entails the use of RT-QuIC analysis of both sample types to diagnose sporadic Creutzfeldt-Jakob disease with nearly 100% accuracy. Here we present a multi-center evaluation (ring trial) of the reproducibility of these improved "second generation" RT-QuIC assays as applied to these diagnostic specimens.
Factors affecting engagement of primary health care professionals and their patients in facilitated access to online alcohol screening and brief intervention.
International journal of medical informatics, 2019

Understanding the impact of Level of Information and Communication Technology Use, computer self-efficacy and perceived product usability of healthcare professionals regarding an alcohol consumption reduction website on facilitated access defined as referring patients to the webpage.