rudyvdbrink/CitationDatabase huggingface dataset:
Perinatal IL-1β-induced inflammation suppresses Tbr2
Brain, behavior, & immunity - health, 2020

Meta-analyses have revealed associations between the incidence of maternal infections during pregnancy, premature birth, smaller brain volumes, and subsequent cognitive, motor and behavioral deficits as these children mature. Inflammation during pregnancy in rodents produces cognitive and behavioral deficits in the offspring that are similar to those reported in human studies. These deficits are accompanied by decreased neurogenesis and proliferation in the subgranular zone (SGZ) of the dentate gyrus (DG) of the hippocampus. As systemically administering interleukin-1 β (IL-1β) to neonatal mice recapitulates many of the brain abnormalities seen in premature babies including developmental delays, the goal of this study was to determine whether IL-1-mediated neuroinflammation would affect hippocampal growth during development to produce cognitive and behavioral abnormalities. For these studies, 10 ​ng/g IL-1β was administered twice daily to Swiss Webster mice during the first 5 days of life, which increased hippocampal levels of IL-1α and acutely reduced the proliferation of Tbr2
Versatile phenotype-activated cell sorting.
Science advances, 2020

Unraveling the genetic and epigenetic determinants of phenotypes is critical for understanding and re-engineering biology and would benefit from improved methods to separate cells based on phenotypes. Here, we report SPOTlight, a versatile high-throughput technique to isolate individual yeast or human cells with unique spatiotemporal profiles from heterogeneous populations. SPOTlight relies on imaging visual phenotypes by microscopy, precise optical tagging of single target cells, and retrieval of tagged cells by fluorescence-activated cell sorting. To illustrate SPOTlight's ability to screen cells based on temporal properties, we chose to develop a photostable yellow fluorescent protein for extended imaging experiments. We screened 3 million cells expressing mutagenesis libraries and identified a bright new variant, mGold, that is the most photostable yellow fluorescent protein reported to date. We anticipate that the versatility of SPOTlight will facilitate its deployment to decipher the rules of life, understand diseases, and engineer new molecules and cells.
Stratification of American hearing aid users by age and audiometric characteristics: a method for representative sampling.
Ear and hearing, 2010

Stratified sampling plans can increase the accuracy and facilitate the interpretation of a dataset characterizing a large population. However, such sampling plans have found minimal use in hearing aid (HA) research, in part because of a paucity of quantitative data on the characteristics of HA users. The goal of this study was to devise a quantitatively derived stratified sampling plan for HA research, so that such studies will be more representative and generalizable, and the results obtained using this method are more easily reinterpreted as the population changes.
Differential calcium channel-mediated dopaminergic modulation in the subthalamonigral synapse.
Synapse (New York, N.Y.), 2020

Dopamine (DA) modulates basal ganglia (BG) activity for initiation and execution of goal-directed movements and habits. While most studies are aimed to striatal function, the cellular and molecular mechanisms underlying dopaminergic regulation in other nuclei of the BG are not well understood. Therefore, we set to analyze the dopaminergic modulation occurring in subthalamo-nigral synapse, in both pars compacta (SNc) and pars reticulata (SNr) neurons, because these synapses are important for the integration of information previously processed in striatum and globus pallidus. In this study, electrophysiological and pharmacological evidence of dopaminergic modulation on glutamate release through calcium channels is presented. Using paired pulse ratio (PPR) measurements and selective blockers of these ionic channels, together with agonists and antagonists of DA D
Increased functional coupling of the mu opioid receptor in the anterior insula of depressed individuals.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021

The mu opioid receptor (MOR) is a G protein-coupled receptor that plays an essential role in reward and hedonic processes, and that has been implicated in disorders such as depression and addiction. Over the last decade, several brain imaging studies in depressed patients have consistently found that dysregulation of MOR function occurs in particular in the anterior insular cortex, an important brain site for the perception of internal states and emotional regulation. To investigate molecular mechanisms that may underlie these effects, here we assessed genetic polymorphisms, expression, and functional G-protein coupling of MOR in a large post-mortem cohort (N = 95) composed of depressed individuals who died by suicide, and healthy controls. Results indicated that depression, but not comorbid substance use disorder or acute opiate consumption, was associated with increased MOR activity. This effect was partly explained by a specific increase in expression of the inhibitory alpha G-protein subunit GNAI2. Consistent with previous neuroimaging studies, our findings support the notion that enhanced endogenous opioidergic tone in the anterior insula may buffer negative affective states in depressed individuals, a mechanism that could potentially contribute to the antidepressant efficacy of emerging opioid-based medications.
Developing a neurally informed ontology of creativity measurement.
NeuroImage, 2020

A central challenge for creativity research-as for all areas of experimental psychology and cognitive neuroscience-is to establish a mapping between constructs and measures (i.e., identifying a set of tasks that best captures a set of creative abilities). A related challenge is to achieve greater consistency in the measures used by different researchers; inconsistent measurement hinders progress toward shared understanding of cognitive and neural components of creativity. New resources for aggregating neuroimaging data, and the emergence of methods for identifying structure in multivariate data, present the potential for new approaches to address these challenges. Identifying meta-analytic structure (i.e., similarity) in neural activity associated with creativity tasks might help identify subsets of these tasks that best reflect the similarity structure of creativity-relevant constructs. Here, we demonstrated initial proof-of-concept for such an approach. To build a model of similarity between creativity-relevant constructs, we first surveyed creativity researchers. Next, we used NeuroSynth meta-analytic software to generate maps of neural activity robustly associated with tasks intended to measure the same set of creativity-relevant constructs. A representational similarity analysis-based approach identified particular constructs-and particular tasks intended to measure those constructs-that positively or negatively impacted the model fit. This approach points the way to identifying optimal sets of tasks to capture elements of creativity (i.e., dimensions of similarity space among creativity constructs), and has long-term potential to meaningfully advance the ontological development of creativity research with the rapid growth of creativity neuroscience. Because it relies on neuroimaging meta-analysis, this approach has more immediate potential to inform longer-established fields for which more extensive sets of neuroimaging data are already available.
No man is an island. A personal tribute to Bob Blanchard and ethoexperimental approaches to the study of behaviour.
Physiology & behavior, 2015

I first met Bob Blanchard at an international conference in Paris some 40 years ago. We collaborated intensively during the late 1980s/early 1990s on the ethopharmacology of antipredator defence in wild and laboratory rats, and remained good friends until his untimely passing in November 2013. Bob will undoubtedly be remembered as one of the most influential behavioural neuroscientists of the 20th century and, with Caroline, the most eloquent advocate of ethoexperimental approaches to the study of behaviour. In this brief trip down memory lane, I describe when and where Bob and I first met and how, over a lengthy period, he directly and indirectly helped shape my own research career. His profound influence in this regard is illustrated by reference to not only our collaborative research on antipredator behaviour but also my other work on the ethopharmacology of agonistic behaviour, social conflict analgesia, anxiety, and appetite. The element common to all of this work has been ethoexperimental analysis and, for teaching me the true value of this approach, I shall always remain indebted to the big man. Literally and figuratively, Bob was most certainly larger than life.
Online control of reach accuracy in mice.
Journal of neurophysiology, 2020

Reaching movements, as a basic yet complex motor behavior, are a foundational model system in neuroscience. In particular, there has been a significant recent expansion of investigation into the neural circuit mechanisms of reach behavior in mice. Nevertheless, quantification of mouse reach kinematics remains lacking, limiting comparison to the primate literature. In this study, we quantitatively demonstrate the homology of mouse reach kinematics to primate reach and also discover novel late-phase correlational structure that implies online control. Overall, our results highlight the decelerative phase of reach as important in driving successful outcome. Specifically, we develop and implement a novel statistical machine-learning algorithm to identify kinematic features associated with successful reaches and find that late-phase kinematics are most predictive of outcome, signifying online reach control as opposed to preplanning. Moreover, we identify and characterize late-phase kinematic adjustments that are yoked to midflight position and velocity of the limb, allowing for dynamic correction of initial variability, with head-fixed reaches being less dependent on position in comparison to freely behaving reaches. Furthermore, consecutive reaches exhibit positional error correction but not hot-handedness, implying opponent regulation of motor variability. Overall, our results establish foundational mouse reach kinematics in the context of neuroscientific investigation, characterizing mouse reach production as an active process that relies on dynamic online control mechanisms.
Glutamatergic fast-spiking parvalbumin neurons in the lateral hypothalamus: Electrophysiological properties to behavior.
Physiology & behavior, 2020

Throughout the central nervous system, neurons expressing the calcium-binding protein parvalbumin have been typically classified as GABAergic with fast-spiking characteristics. However, new methods that allow systematic characterization of the cytoarchitectural organization, connectivity, activity patterns, neurotransmitter nature, and function of genetically-distinct cell types have revealed populations of parvalbumin-positive neurons that are glutamatergic. Remarkably, such findings challenge longstanding concepts that fast-spiking neurons are exclusively GABAergic, suggesting conservation of the fast-spiking phenotype across at least two neurotransmitter systems. This review focuses on the recent advancements that have begun to reveal the functional roles of lateral hypothalamic parvalbumin-positive neurons in regulating behaviors essential for survival.
Cardiac-Related Spinal Cord Tissue Motion at the Foramen Magnum is Increased in Patients with Type I Chiari Malformation and Decreases Postdecompression Surgery.
World neurosurgery, 2018

Type 1 Chiari malformation (CM-I) is a craniospinal disorder historically defined by cerebellar tonsillar position greater than 3-5 mm below the foramen magnum (FM). This definition has come under question because quantitative measurements of cerebellar herniation do not always correspond with symptom severity. Researchers have proposed several additional radiographic diagnostic criteria based on dynamic motion of fluids and/or tissues. The present study objective was to determine if cardiac-related craniocaudal spinal cord tissue displacement is an accurate indicator of the presence of CM-I and if tissue displacement is altered with decompression.
An interview with Steve Wilson. Interview by Kathryn Senior.
Development (Cambridge, England), 2010

Stephen Wilson is Professor of Developmental Genetics at University College, London, UK. He was recently awarded the Remedios Caro Almela Prize for Research in Developmental Neurobiology. We interviewed Steve to find out about how he started on the road to developmental biology research, how he got interested in the brain, his achievements and future challenges.
Influence of vision and posture on grip-lift task parameters in healthy adults.
International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation, 2014

The grip-lift task enables a quantitative assessment of grasping ability. Patients are regularly assessed in a supine position, which offers a different view of the grasped object from that in the sitting position. To our knowledge, no data are currently available on the influence of posture and vision on grip-lift task parameters. We therefore aimed to determine the effects of posture and vision on these parameters. Twenty-six healthy right-handed adults performed grip-lift tasks with a manipulandum that measured different temporal and dynamic parameters in four conditions: sitting eyes open, sitting blindfolded, lying down eyes open and lying down blindfolded. A repeated-measures analysis of variance with two factors (vision and position) showed that the absence of vision affected all the parameters measured. The lying down position increased the time between the first contact with the object and the modification of the vertical force as well as the delay between the first increase of the horizontal force and the increase of the vertical force. In addition, there was a lower adaption of the horizontal force, required to squeeze the object, to the vertical force. Finally, the interaction of position and vision was associated with significant differences in the delay between the contact of each digit with the object, the maximum horizontal force and the ratio between the horizontal and vertical force during a static holding period. Both position and vision appear to affect the grip-lift task. Consequently, sequential assessments should be performed in the same condition to obtain reliable data.
AMPed-up adolescents: The role of age in the abuse of amphetamines and its consequences on cognition and prefrontal cortex development.
Pharmacology, biochemistry, and behavior, 2020

Adolescent use of amphetamine and its closely related, methylated version methamphetamine, is alarmingly high in those who use drugs for nonmedical purposes. This raises serious concerns about the potential for this drug use to have a long-lasting, detrimental impact on the normal development of the brain and behavior that is ongoing during adolescence. In this review, we explore recent findings from both human and laboratory animal studies that investigate the consequences of amphetamine and methamphetamine exposure during this stage of life. We highlight studies that assess sex differences in adolescence, as well as those that are designed specifically to address the potential unique effects of adolescent exposure by including groups at other life stages (typically young adulthood). We consider epidemiological studies on age and sex as vulnerability factors for developing problems with the use of amphetamines, as well as human and animal laboratory studies that tap into age differences in use, its short-term effects on behavior, and the long-lasting consequences of this exposure on cognition. We also focus on studies of drug effects in the prefrontal cortex, which is known to be critically important for cognition and is among the later maturing brain regions. Finally, we discuss important issues that should be addressed in future studies so that the field can further our understanding of the mechanisms underlying adolescent use of amphetamines and its outcomes on the developing brain and behavior.
Complex Interaction between Resident Microbiota and Misfolded Proteins: Role in Neuroinflammation and Neurodegeneration.
Cells, 2020

Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD) and Creutzfeldt-Jakob disease (CJD) are brain conditions affecting millions of people worldwide. These diseases are associated with the presence of amyloid-β (Aβ), alpha synuclein (α-Syn) and prion protein (PrP) depositions in the brain, respectively, which lead to synaptic disconnection and subsequent progressive neuronal death. Although considerable progress has been made in elucidating the pathogenesis of these diseases, the specific mechanisms of their origins remain largely unknown. A body of research suggests a potential association between host microbiota, neuroinflammation and dementia, either directly due to bacterial brain invasion because of barrier leakage and production of toxins and inflammation, or indirectly by modulating the immune response. In the present review, we focus on the emerging topics of neuroinflammation and the association between components of the human microbiota and the deposition of Aβ, α-Syn and PrP in the brain. Special focus is given to gut and oral bacteria and biofilms and to the potential mechanisms associating microbiome dysbiosis and toxin production with neurodegeneration. The roles of neuroinflammation, protein misfolding and cellular mediators in membrane damage and increased permeability are also discussed.
Distinct feedback actions of behavioural arousal to the master circadian clock in nocturnal and diurnal mammals.
Neuroscience and biobehavioral reviews, 2021

The master clock in the suprachiasmatic nucleus (SCN) of the hypothalamus provides a temporal pattern of sleep and wake that - like many other behavioural and physiological rhythms - is oppositely phased in nocturnal and diurnal animals. The SCN primarily uses environmental light, perceived through the retina, to synchronize its endogenous circadian rhythms with the exact 24 h light/dark cycle of the outside world. The light responsiveness of the SCN is maximal during the night in both nocturnal and diurnal species. Behavioural arousal during the resting period not only perturbs sleep homeostasis, but also acts as a potent non-photic synchronizing cue. The feedback action of arousal on the SCN is mediated by processes involving several brain nuclei and neurotransmitters, which ultimately change the molecular functions of SCN pacemaker cells. Arousing stimuli during the sleeping period differentially affect the circadian system of nocturnal and diurnal species, as evidenced by the different circadian windows of sensitivity to behavioural arousal. In addition, arousing stimuli reduce and increase light resetting in nocturnal and diurnal species, respectively. It is important to address further question of circadian impairments associated with shift work and trans-meridian travel not only in the standard nocturnal laboratory animals but also in diurnal animal models.
A summary of the proceedings of the Eleventh International Symposium on the Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria, July 29-August 3, 2012.
Experimental gerontology, 2013

A summary of the Eleventh International Symposium on the Neurobiology and Neuroendocrinology of Aging that was held in July 29-August 3 in Bregenz, Austria, is presented. Sixteen of the speakers who presented at the conference submitted review papers covering the topic of their presentation as well as an overview of their respective fields and are included in this special issue. The abstracts from each poster presentation are also included at the end of the special issue.
C6 deficiency does not alter intrinsic regeneration speed after peripheral nerve crush injury.
Neuroscience research, 2014

Peripheral nerve injury leads to Wallerian degeneration, followed by regeneration, in which functionality and morphology of the nerve are restored. We previously described that deficiency for complement component C6, which prevents formation of the membrane attack complex, slows down degeneration and results in an earlier recovery of sensory function after sciatic nerve injury compared to WT animals. In this study, we determine whether C6(-/-) rats have an intrinsic trait that affects sciatic nerve regeneration after injury. To study the contribution of complement activation on degeneration and regeneration with only minimal effect of complement activation, a crush injury model with only modest complement deposition was used. We compared the morphological and functional aspects of crushed nerves during degeneration and regeneration in C6(-/-) and WT animals. Morphological changes of myelin and axons showed similar degeneration and regeneration patterns in WT and C6(-/-) injured nerves. Functional degeneration and regeneration, recorded by ex vivo electrophysiology and in vivo foot flick test, showed that the timeline of the restoration of nerve conduction and sensory recovery also followed similar patterns in WT and C6(-/-) animals. Our findings suggest that C6 deficiency by itself does not alter the regrowth capacity of the peripheral nerve after crush injury.
Intravitreal Dexamethasone Implant as a Sustained Release Drug Delivery Device for the Treatment of Ocular Diseases: A Comprehensive Review of the Literature.
Pharmaceutics, 2020

Drug delivery into the vitreous chamber remains a great challenge in the pharmaceutical industry due to the complex anatomy and physiology of the eye. Intravitreal injection is the mainstream route of drug administration to the posterior segment of the eye. The purpose of this review is to assess the current literature about the widening use of the intravitreal 0.7 mg dexamethasone (Dex) implant, and to provide a comprehensive collection of all the ocular disorders that benefit from Dex administration. Although anti-vascular endothelial growth-factors (VEGFs) have been largely indicated as a first-choice level, the Dex implant represents an important treatment option, especially in selected cases, such as vitrectomized eyes or patients in whom anti-VEGF failed or are contraindicated. In this article, the safety profile as well as the list of the possible complications related to intravitreal Dex injection are also discussed.
Unexplained repeated pregnancy loss is associated with altered perceptual and brain responses to men's body-odor.
eLife, 2020

Mammalian olfaction and reproduction are tightly linked, a link less explored in humans. Here, we asked whether human unexplained repeated pregnancy loss (uRPL) is associated with altered olfaction, and particularly altered olfactory responses to body-odor. We found that whereas most women with uRPL could identify the body-odor of their spouse, most control women could not. Moreover, women with uRPL rated the perceptual attributes of men's body-odor differently from controls. These pronounced differences were accompanied by an only modest albeit significant advantage in ordinary, non-body-odor-related olfaction in uRPL. Next, using structural and functional brain imaging, we found that in comparison to controls, most women with uRPL had smaller olfactory bulbs, yet increased hypothalamic response in association with men's body-odor. These findings combine to suggest altered olfactory perceptual and brain responses in women experiencing uRPL, particularly in relation to men's body-odor. Whether this link has any causal aspects to it remains to be explored.