rudyvdbrink/CitationDatabase huggingface dataset:
The role of the 'central' cholecystokinin-B receptor in panic disorder.
Acta neuropsychiatrica, 1996

Research investigating the neurobiological underpinnings of anxiety disorder have mainly been focused on dysfunction of the GABA, noradrenergic and serotonergic (5-HT) neuronal systems. Just recently, in both animal and human studies, evidence has been found for a possible role of the cholecystokinin (CCK) neuronal system in the pathogenesis of anxiety disorder. Behaviorally, animal studies revealed anxiogenic-like properties for the 'central' CCKB receptor agonists, while CCKB receptor antagonists displayed intrinsic anxiolytic properties. Similarly, in man, CCKB receptor agonists, like pentagastrin and CCK4, were found to be able to elicited panic attacks in both panic disorder (PD) patients and healthy volunteers. These effects appear due to stimulation of the CCKB receptor. In addition, clinically effective panicolytic agents reduce the sensitivity to CCK4 in PD patients. Taken together, these findings may suggest a role for CCK in the neurobiology of PD. On the other hand, there is circumstantial evidence for involvement of several other neuronal systems, such as the serotonergic, noradrenergic and GABA-ergic system, in the regulation of anxiety. Interestingly, evidence has been found for an interaction between CCK and 5-HT and that this interaction plays a role in the mediation of anxiety. This presentation will critically discuss the evidence for the role of the CCKB receptor in anxiety and in addition, will focus on the putative evidence that the role of CCK in anxiety is mediated by its interaction with the serotonergic neuronal system.
Go with the flow: A neuroscientific view on being fully engaged.
The European journal of neuroscience, 2021

Flow is a state of full task absorption, accompanied with a strong drive and low levels of self-referential thinking. Flow is likely when there is a match between a person's skills and the task challenge. Despite its relevance for human performance and the vast body of research on flow, there is currently still relatively little insight in its underlying neurocognitive mechanisms. In this paper, we discuss a set of large brain networks that may be involved in establishing the core dimensions of flow. We propose that dopaminergic and noradrenergic systems mediate the intrinsic motivation and activate mood states that are typical for flow. The interaction between three large-scale attentional networks, namely the Default Mode Network, Central Executive Network and the Salience Network is proposed to play a role in the strong task engagement, low self-referential thinking, feedback and feelings of control in flow. The proposed relationships between flow and the brain networks may support the generation of new hypotheses and can guide future research in this field.
Spreading activation in nonverbal memory networks.
Brain informatics, 2017

Theories of spreading activation primarily involve semantic memory networks. However, the existence of separate verbal and visuospatial memory networks suggests that spreading activation may also occur in visuospatial memory networks. The purpose of the present investigation was to explore this possibility. Specifically, this study sought to create and describe the design frequency corpus and to determine whether this measure of visuospatial spreading activation was related to right hemisphere functioning and spreading activation in verbal memory networks. We used word frequencies taken from the Controlled Oral Word Association Test and design frequencies taken from the Ruff Figural Fluency Test as measures of verbal and visuospatial spreading activation, respectively. Average word and design frequencies were then correlated with measures of left and right cerebral functioning. The results indicated that a significant relationship exists between performance on a test of right posterior functioning (Block Design) and design frequency. A significant negative relationship also exists between spreading activation in semantic memory networks and design frequency. Based on our findings, the hypotheses were supported. Further research will need to be conducted to examine whether spreading activation exists in visuospatial memory networks as well as the parameters that might modulate this spreading activation, such as the influence of neurotransmitters.
Lateral transmaxillosphenoidal approach to the lateral compartment of the cavernous sinus: technical case report.
Skull base : official journal of North American Skull Base Society ... [et al.], 2007

This article outlines the surgical technique and the indications for the lateral transmaxillosphenoidal approach, which is illustrated by an index case. A 27-year-old woman presented with a trigeminal sensory deficit caused by a dermoid tumor occupying the lateral compartment of her right cavernous sinus. A lateral transmaxillosphenoidal approach was performed, and the tumor was removed lateral to the intracavernous carotid artery (ICA) and medial to intracavernous cranial nerves. The lateral transmaxillosphenoidal approach is similar to the transmaxillosphenoidal approach used for the removal of pituitary adenomas invading the medial compartment of the cavernous sinus. By opening the lateral wall of the sphenoid sinus just above and laterally to the carotid artery, tumor can be removed medial to the intracavernous cranial nerves and lateral to the ICA.
Differential Covariance: A New Method to Estimate Functional Connectivity in fMRI.
Neural computation, 2020

Measuring functional connectivity from fMRI recordings is important in understanding processing in cortical networks. However, because the brain's connection pattern is complex, currently used methods are prone to producing false functional connections. We introduce differential covariance analysis, a new method that uses derivatives of the signal for estimating functional connectivity. We generated neural activities from dynamical causal modeling and a neural network of Hodgkin-Huxley neurons and then converted them to hemodynamic signals using the forward balloon model. The simulated fMRI signals, together with the ground-truth connectivity pattern, were used to benchmark our method with other commonly used methods. Differential covariance achieved better results in complex network simulations. This new method opens an alternative way to estimate functional connectivity.
Transcranial Magnetic Resonance Imaging-Guided Focused Ultrasound with a 1.5 Tesla Scanner: A Prospective Intraindividual Comparison Study of Intraoperative Imaging.
Brain sciences, 2021

High-quality intraoperative imaging is needed for optimal monitoring of patients undergoing transcranial MR-guided Focused Ultrasound (tcMRgFUS) thalamotomy. In this paper, we compare the intraoperative imaging obtained with dedicated FUS-Head coil and standard body radiofrequency coil in tcMRgFUS thalamotomy using 1.5-T MR scanner.
Pregnancy modulates precursor cell proliferation in a murine model of focal demyelination.
Neuroscience, 2010

In mice, pregnancy has been shown to have a beneficial effect on the endogenous repair of focal lysolecithin-induced CNS demyelinative lesions, enhancing the genesis of new oligodendrocytes and the degree of remyelination. To identify local cells undergoing mitosis in response to such lesions, we examined the time course of phospho-histone H3 (PH3) and myelin basic protein (MBP) expression by immunohistochemistry. After lysolecithin injection into the corpus callosum of virgin female mice, the number of dividing cells peaked about 48 h after injection and declined gradually to baseline by day 7; in pregnant mice, this initial peak was unchanged, but a new delayed peak on day 4 was induced. Colocalization data using PH3 and NG2 proteoglycan, or bromodeoxyuridine (BrdU) and oligodendrocyte transcription factor 1 (Olig1), suggested that about 75% of the proliferating cells on day 2, and about 40% of the cells on day 4, were likely of oligodendrocyte lineage; these differential percentages were of the same magnitude in both virgin and pregnant animals. Notably, the heightened proliferative response to focal lysolecithin injection during pregnancy was specific to gestational stage (early, but not late) and to lesion location (in the corpus callosum of the periventricular forebrain, but not in the caudal cerebellar peduncle of the hindbrain).
Test-retest variation in macular thickness measurements with the Heidelberg Retina Tomograph.
Clinical & experimental optometry, 2012

The aim was to evaluate the test-retest variation of macular thickness measurements using the Heidelberg Retina Tomograph (HRT3) Retina Module and compare it with the Stratus optical coherence tomography (OCT). As no normative data has been published for the HRT Retina Module, a secondary purpose was to obtain reference values for this technique.
Pharmacological regulation of gene expression.
Pharmacological research, 2011

Pharmacological regulation of gene expression was one of the top professional interests of Dr. Costa. He promoted the idea that drugs can improve the endogenous mechanisms of synaptic plasticity by modulating gene expression. In this article I reflect upon Dr. Costa's leadership in projects undertaken at FGIN that were aimed at elucidating how neurotransmitter receptor activation could affect brain function by modulating genes and their products. I will be presenting examples of how pharmacological tools can change gene expression. These include the ability of drugs of abuse to alter the synthesis of opioid peptides or an endogenous ligand for GABAA receptor. I will conclude with a brief summary of intriguing discoveries about the regulation of nerve growth factor (NGF) and its receptors by beta-receptor agonists, adrenal steroids and cytokines.
Visual form perception predicts 3-year longitudinal development of mathematical achievement.
Cognitive processing, 2020

Numerous studies have demonstrated an association between approximate number system (ANS) acuity and mathematical performance. Studies have also shown that ANS acuity can predict the longitudinal development of mathematical achievement. Visual form perception in the current investigation was proposed to account for the predictive role of ANS acuity in the development of mathematical achievement. One hundred and eighty-eight school children (100 males, 88 females; mean age = 12.2 ± 0.3 years) participated in the study by completing five tests: numerosity comparison, figure matching, mental rotation, nonverbal matrix reasoning, and choice reaction time. Three years later, they took a mathematical achievement test. We assessed whether the early tests predicted mathematical achievement at the later date. Analysis showed that the ANS acuity measured via numerosity comparison significantly predicted mathematical achievement 3 years later, even when controlling for individual differences in mental rotation, nonverbal matrix reasoning, and choice reaction time, as well as age and gender differences. Hierarchical regression and mediation analyses further showed that the longitudinal predictive role of ANS acuity in mathematical achievement was interpreted by visual form perception measured with a figure-matching test. Together, these results indicate that visual form perception may be the underlying cognitive mechanism that links ANS acuity to mathematical achievement in terms of longitudinal development.
Resistin is co-secreted with adiponectin in white mouse adipocytes.
Biochemical and biophysical research communications, 2021

In the current work we have investigated the cellular and molecular regulation of resistin secretion in cultured and primary mouse adipocytes. Resistin is an adipose tissue hormone proposed to contribute to metabolic disease. In rodents, resistin is secreted from white adipocytes whereas it is in humans synthesised and released from other cell types within white adipose tissue. The metabolic importance of resistin has been studied in both mouse and man, but the regulation of its release remains poorly investigated. Here we define that, in mouse adipocytes, resistin secretion is triggered by an intracellular elevation of cAMP and/or Ca
Optimizing actigraphic estimates of polysomnographic sleep features in insomnia disorder.
Sleep, 2020

Actigraphy is a useful tool for estimating sleep, but less accurately distinguishes sleep and wakefulness in patients with insomnia disorder (ID) than in good sleepers. Specific algorithm parameter settings have been suggested to improve the accuracy of actigraphic estimates of sleep onset or nocturnal sleep and wakefulness in ID. However, a direct comparison of how different algorithm parameter settings affect actigraphic estimates of sleep features has been lacking. This study aimed to define the optimal algorithm parameter settings for actigraphic estimates of polysomnographic sleep features in people suffering from ID and matched good sleepers.
Prenatal maternal stress prospectively relates to shorter child buccal cell telomere length.
Psychoneuroendocrinology, 2020

Prenatal exposure to stress increases risk for suboptimal child and adult mental and physical health outcomes, hypothesized to occur via fetal exposure to maternal stress hormones that alter growth and development. One proposed pathway through which stress exposure in utero could affect the offspring is by accelerating cellular aging in the form of telomere attrition. We tested this hypothesis in a cohort of 111 mother-child dyads, where mothers were assessed over 6 or more years, beginning prior to conception, and later during pregnancy, postpartum, and when the children were 3-5 years old. Adjusting for child age and concurrent maternal stress, we found that higher maternal perceived stress in the 3rd trimesters of pregnancy was predictive of shorter child buccal telomere length (bTL) (β = -0.24, p < .05), while maternal preconception and postpartum maternal stress were not associated with bTL (all p's > 0.42). These findings suggest a vulnerable time period in pregnancy when maternal stress influences offspring telomere length, suggesting the early embedding of adult disease might occur through biological aging pathways.
Pharmacological depletion of serotonin and norepinephrine with para-chlorophenylalanine and alpha-methyl-p-tyrosine reverses the antidepressant-like effects of adolescent caffeine exposure in the male rat.
Behavioural pharmacology, 2020

Adolescent exposure to caffeine has been shown to decrease immobility in the forced swim test, suggesting and antidepressant-like effect of caffeine; however, studies have produced different results with regard to caffeine-induced active behaviors. The present study attempted to clarify the possible neurochemical mechanisms of caffeine's action by selectively depleting norepinephrine with alpha-methyl-p-tyrosine or serotonin with para-chlorophenylalanine in two separate experiments and assessing the ability for caffeine to alter anxiety-like and depressive-like behavior. Caffeine-treated adolescent male rats were exposed to caffeine (0.25 g/L) in their drinking water beginning on P28. A-methyl-p-tyrosine, para-chlorophenylalanine, or saline were administered prior to light-dark, open field, and forced swim testing beginning on P45. Caffeine-induced reductions in immobility and increases in swimming in the forced swim test were reversed by both a-methyl-p-tyrosine and para-chlorophenylalanine. Caffeine-induced increases in crosses and rears were reversed by para-chlorophenylalanine but not alpha-methyl-p-tyrosine, whereas caffeine-induced increases in transitions in the LD test were reversed by alpha-methyl-p-tyrosine but not para-chlorophenylalanine. Taken together, these results suggest that caffeine-induced decreases in immobility in male rats requires both norepinephrine and serotonin as depletion of either prevents the induction of immobility by chronic caffeine.
Efficacy outcomes reported in trials of multiple sclerosis: A systematic scoping review.
Multiple sclerosis and related disorders, 2020

This study aimed to map the outcome measures of clinical efficacy reported in Randomized Controlled Trials (RCT) to evaluate disease-modifying therapies (DMT) in patients with relapsing forms of multiple sclerosis (RMS).
Youth and gambling disorder: What about criminal behavior?
Addictive behaviors, 2021

The commission of illegal acts has been associated with gambling disorder (GD). However, little is known about young adults with GD who commit GD-related crimes. Therefore, the main aim of this study was to compare sociodemographic, clinical, personality and psychopathological features among young adults with GD with and without a history of illegal behaviors. Our second aim was to analyze the specific associations between these factors through a path analysis.
Recurrent Leiomyosarcoma of the Small Bowel: A Case Series.
Anticancer research, 2020

Leiomyosarcoma is an extremely rare, small bowel neoplasm (2% of all gastrointestinal tumours). Early diagnosis is challenging due to the slow growth of the cancer. The biological behaviour of this group of tumours is aggressive, and the first-line treatment is surgical resection.
Examining the Role of Microbiota in Emotional Behavior: Antibiotic Treatment Exacerbates Anxiety in High Anxiety-Prone Male Rats.
Neuroscience, 2021

Intestinal microbiota are essential for healthy gastrointestinal function and also broadly influence brain function and behavior, in part, through changes in immune function. Gastrointestinal disorders are highly comorbid with psychiatric disorders, although biological mechanisms linking these disorders are poorly understood. The present study utilized rats bred for distinct emotional behavior phenotypes to examine relationships between emotionality, the microbiome, and immune markers. Prior work showed that Low Novelty Responder (LR) rats exhibit high levels of anxiety- and depression-related behaviors as well as myriad neurobiological differences compared to High Novelty Responders (HRs). Here, we hypothesized that the divergent HR/LR phenotypes are accompanied by changes in fecal microbiome composition. We used next-generation sequencing to assess the HR/LR microbiomes and then treated adult HR/LR males with an antibiotic cocktail to test whether it altered behavior. Given known connections between the microbiome and immune system, we also analyzed circulating cytokines and metabolic factors to determine relationships between peripheral immune markers, gut microbiome components, and behavioral measures. There were no baseline HR/LR microbiome differences, and antibiotic treatment disrupted the microbiome in both HR and LR rats. Antibiotic treatment exacerbated aspects of HR/LR behavior, increasing LRs' already high levels of anxiety-like behavior while reducing passive stress coping in both strains. Our results highlight the importance of an individual's phenotype to their response to antibiotics, contributing to the understanding of the complex interplay between gut microbes, immune function, and an individual's emotional phenotype.
Sigma-1 antagonism inhibits binge ethanol drinking at adolescence.
Drug and alcohol dependence, 2020

Ethanol use during adolescence is a significant health problem, yet the pharmacological treatments to reduce adolescent binge drinking are scarce. The present study assessed, in male and female adolescent Wistar rats, if the sigma-1 receptor (S1-R) antagonists S1RA or BD-1063 disrupted ethanol drinking.
Semantic reversal anomalies under the microscope: Task and modality influences on language-associated event-related potentials.
The European journal of neuroscience, 2020

Semantic reversal anomalies (SRAs)-sentences where an implausibility is created by reversing participant roles-have attracted much attention in the literature on the electrophysiology of language. In spite of being syntactically well formed but semantically implausible, these sentences unexpectedly elicited a monophasic P600 effect in English and Dutch rather than an N400 effect. Subsequent research revealed variability in the presence/absence of an N400 effect to SRAs depending on the language examined and the choice of verb type in English. However, most previous studies employed the same presentation modality (visual) and task (acceptability judgement). Here, we conducted two experiments and three statistical analyses to investigate the influence of stimulus modality, task demand and statistical choices on event-related potential (ERP) response patterns to SRAs in English. We reproduced a previous study's procedure and analysis (N. Bourguignon et al. (2012) Brain and Language, 122, 179-189) and further introduced between-subjects factors of task type and modality, using mixed-effects modelling to analyse the data. We observed an N400 effect to typical English SRAs (agent subject verbs, e.g. "the fries will eat the boys"), which contrasts existing literature and was not predicted by existing theories that account for SRA processing. Task demand modulated the ERPs elicited by SRAs, while auditory presentation led to increased comprehension accuracy and a more broadly distributed ERP. Finally, the statistical methods used influenced the presence/absence of ERP effects. Our results suggest a sensitivity of language-related ERP patterns to methodological parameters, and we conclude that future experiments should take this into careful consideration.
[Autoantibodies in Chronic Inflammatory Demyelinating Polyneuropathy].
Brain and nerve = Shinkei kenkyu no shinpo, 2018

Recent reserch has successfully identified several autoantibodies in chronic inflammatory demyelinating polyneuropathy (CIDP). Most of those identified were IgG4 antibodies targeting cell adhesion molecules around the node of Ranvier of myelinated fibers. In particular, much has been learned concerning the pathogenic roles of antibodies against neurofascin 155. Growing evidence has revealed that patients with CIDP with these antibodies are characterized by IVIg-resistance and lack typical demyelinating findings on biopsied nerve fibers, both of which could make diagnosis and treatment difficult without autoantibody measurement. Clinicians should recognize that it is now essential to measure autoantibodies in CIDP and utilize antibody testing.
Automated end-to-side anastomosis to the middle cerebral artery with C-Port xA: A feasibility study on human cadavers.
Asian journal of neurosurgery, 2013

Anastomosis to the superficial temporal artery is suitable in patients with functional and structural impairment of the middle cerebral artery (i.e., complex aneurysms and skull base tumors), as either definitive treatment or an additional safety measure. A shorter occlusion time or a non-occlusive technique is expected to reduce the risk of cerebral ischemia following the procedure. In this cadaver study, we assessed the fitness of C-Port xA(®) device for use in superficial temporal artery (STA)-middle cerebral artery (MCA) bypass.
Pitolisant for Residual Excessive Daytime Sleepiness in OSA Patients Adhering to CPAP: A Randomized Trial.
Chest, 2021

Excessive daytime sleepiness (EDS) in individuals with OSA syndrome persisting despite good adherence to CPAP is a disabling condition. Pitolisant is a selective histamine H3-receptor antagonist with wake-promoting effects.
Alemtuzumab outcomes by age: Post hoc analysis from the randomized CARE-MS studies over 8 years.
Multiple sclerosis and related disorders, 2021

Alemtuzumab significantly improved clinical and MRI outcomes vs. subcutaneous interferon beta-1a (SC IFNB-1a) in the CARE-MS trials (NCT00530348, NCT00548405), with sustained efficacy in 2 consecutive extensions (NCT00930553, NCT02255656 [TOPAZ]).