rudyvdbrink/CitationDatabase huggingface dataset:
Imaging of Murine Whole Lung Fibrosis by Large Scale 3D Microscopy aided by Tissue Optical Clearing.
Scientific reports, 2018

Pulmonary fibrosis, characterized by excessive collagen deposition in the lungs, comprises a key and debilitating component of chronic lung diseases. Methods are lacking for the direct visualization of fibrillar collagen throughout the whole murine lung, a capability that would aid the understanding of lung fibrosis. We combined an optimized organ-level optical clearing (OC) approach with large-scale, label-free multiphoton microscopy (MPM) and second harmonic generation microscopy (SHGM) to reveal the complete network of fibrillar collagen in whole murine lungs. An innate inflammation-driven model based on repetitive poly(I:C) challenge was evaluated. Following OC, mosaic MPM/SHGM imaging with 3D reconstruction and whole organ quantitative analysis revealed significant differences in collagen deposition between PBS and poly(I:C) treated lungs. Airway specific analysis in whole lung acquisitions revealed significant sub-epithelial fibrosis evident throughout the proximal conductive and distal airways with higher collagen deposition in the poly(I:C) group vs PBS group. This study establishes a new, powerful approach based on OC and MPM/SHGM imaging for 3D analysis of lung fibrosis with macroscopic views of lung pathology based on microscopy and providing a new way to analyze the whole lung while avoiding regional sampling bias.
Interception by two predatory fly species is explained by a proportional navigation feedback controller.
Journal of the Royal Society, Interface, 2018

When aiming to capture a fast-moving target, animals can follow it until they catch up, or try to intercept it. In principle, interception is the more complicated strategy, but also more energy efficient. To study whether simple feedback controllers can explain interception behaviours by animals with miniature brains, we have reconstructed and studied the predatory flights of the robber fly
Lose it to use it.
The Journal of cell biology, 2021

In this issue, Wang et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.201911114) describe a phenomenon in which neuromuscular junction synapse elimination triggers myelination of terminal motor axon branches. They propose a mechanism initiated by synaptic pruning that depends on synaptic activity, cytoskeletal maturation, and the associated anterograde transport of trophic factors including Neuregulin 1-III.
Dyskinetopsic Palinopsia: Palinopsia Accompanied by Moving Afterimages.
Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology, 2020

Palinopsia refers to the abnormal persistence, or recurrence, of visual images after a visual stimulus has subsided. We describe here a case of palinopsia accompanied by a visual motion perception disorder as manifested by moving afterimages. A 71-year-old man presented to us after having experienced acute-onset, vivid, visual hallucinations for 1 week. A detailed history revealed that he was hallucinating multiple living and nonliving objects. He also complained of a persistence of afterimages, particularly in the left visual field. He reported that, on a few occasions, while sitting by the window in his room, he had seen a moving car on the road; immediately after the car had disappeared from his sight, he had then seen the same car moving backward at almost the same speed-as if the driver had applied the reverse gear. A neuropsychological assessment did not reveal any deficits in attention, language, or episodic memory. Visual field testing by confrontational perimetry suggested left hemianopia. An MRI of the brain revealed an arteriovenous malformation in the medial part of the right occipital lobe, affecting both the lingual gyrus and the inferior occipital gyrus. Palinopsia has generally been described in reference to static afterimages. In our case, not only was the afterimage that was perceived by the patient in motion, but the direction of the movement was also opposite to that of the actual object. We propose the term dyskinetopsic palinopsia, or simply motion-related palinopsia, for this particular condition.
Trigeminal neuralgia associated with multiple sclerosis: A multimodal assessment of brainstem plaques and response to Gamma Knife radiosurgery.
Multiple sclerosis (Houndmills, Basingstoke, England), 2020

Gamma Knife radiosurgery (GKRS) is a minimally invasive procedure for trigeminal neuralgia secondary to multiple sclerosis (MS-TN). Patients with MS-TN experience suboptimal response rates to treatment, and the relationship between trigeminal microstructure and treatment outcome is poorly understood.
Cost-effectiveness analysis of invasive EEG monitoring in drug-resistant epilepsy.
Epilepsy & behavior : E&B, 2021

Our aim was to determine the cost-effectiveness of two intracranial electroencephalography (iEEG) interventions: 1) stereoelectroencephalography (SEEG) and 2) placement of subdural grid electrodes (SDGs) both followed by resective surgery in patients with drug-resistant, partial-onset epilepsy, compared with medical management (MM) in Hungary from payer's perspective.
Brain decoding in multiple languages: Can cross-language brain decoding work?
Brain and language, 2021

The approach of cross-language brain decoding is to use models of brain decoding from one language to decode stimuli of another language. It has the potential to provide new insights into how our brain represents multiple languages. While it is possible to decode semantic information across different languages from neuroimaging data, the approach's overall success remains to be tested and depends on a number of factors such as cross-language similarity, age of acquisition/proficiency levels, and depth of language processing. We expect to see continued progress in this domain, from a traditional focus on words and concrete concepts toward the use of naturalistic experimental tasks involving higher-level language processing (e.g., discourse processing). The approach can also be applied to understand how cross-modal, cross-cultural, and other nonlinguistic factors may influence neural representations of different languages. This article provides an overview of cross-language brain decoding with suggestions for future research directions.
Biomarker profiles of endothelial activation and dysfunction in rare systemic autoimmune diseases: implications for cardiovascular risk.
Rheumatology (Oxford, England), 2021

Vasculopathy is an important hallmark of systemic chronic inflammatory connective tissue diseases (CICTD) and is associated with increased cardiovascular risk. We investigated disease-specific biomarker profiles associated with endothelial dysfunction, angiogenic homeostasis and (tissue) inflammation, and their relation to disease activity in rare CICTD.
Tamsulosin plus a new complementary and alternative medicine in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: Results from a retrospective comparative study.
Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica, 2020

We aimed to compare the efficacy of tamsulosin 0.4 mg once a day alone and the combination therapy involving tamsulosin 0.4 mg once a day plus the complementary and alternative medicine consisting of vitamins (C and D), herbal products (Cucurbita maxima, Capsicum annum, Polygonum capsicatum) and amino acid L-Glutamine bid in patients with lower urinary tract symptoms related to benign prostatic hyperplasia (LUTS/BPH).
Effect of intranasal oxytocin administration on self-other distinction: Modulations by psychological distance and gender.
Psychoneuroendocrinology, 2020

Preliminary evidence indicates that intranasal oxytocin (OT) administration modulates one's ability to distinguish oneself from others (i.e., self-other distinction). However, previous findings on this topic are contradictory. The current study addressed this issue by (i) using a novel perceptual matching task examining self-other distinction compared to both close and distant others, and (ii) tentatively exploring potential modulations by gender. In a double-blind, placebo-controlled, randomized OT administration study, 100 participants (50 males and 50 females) were randomized to receive intranasal spray of 24 IU OT or placebo (PL). Afterwards, participants completed a geometry perceptual matching task in which different shapes were paired to the self, a friend, or a stranger. Participants were then asked to judge whether each pair of shapes and labels was correctly matched. The results revealed that compared to PL administration, OT facilitated distinction between the self and a friend in males but not in females. These findings provide insights for debates on the role of OT in self-other distinction by revealing modulations by psychological distance and gender, which have implications for the potential clinical applications of OT.
Identification and Evaluation of Bisquinoline Scaffold as a New Candidate for α-Synuclein-PET Imaging.
ACS chemical neuroscience, 2020

α-Synuclein (α-syn) aggregates are pathologically associated with the hallmarks found in brains affected by synucleinopathies such as Parkinson's disease (PD) and multiple system atrophy (MSA). Therefore, the
An In Vitro Partial Lesion Model of Differentiated Human Mesencephalic Neurons: Effect of Pericyte Secretome on Phenotypic Markers.
Journal of molecular neuroscience : MN, 2020

Parkinson's disease (PD) is characterised by the progressive degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta. Post-mortem data suggests that the loss of DA markers may long precede the cell death, leaving a window to rescue the DA phenotype. Screening for potential neuroprotective or restorative therapies, however, requires that partial lesions of DA neurons can be modelled in vitro. In order to establish a partial lesion model of DA neurons in vitro, we evaluated the effects of different exposure times to 1-methyl-4-phenylpyridinium (MPP
[On schizophrenic passivity].
Der Nervenarzt, 2008

Using a case history this paper attempts to define a certain temporal orientation peculiar to schizophrenic passivity. In agreement with Straus, we divide the present into two modes, one before confirmation of an action and one after. The former mode is termed the immediate present, and the latter is the nonimmediate present. Due to the requirement of recording procedure in neuroscience, it usually is unable to deal with questions of the immediate present. This leads to a"discovery" that cerebral initiation of a voluntary act arises prior to our conscious awareness of the intention to act. Such a belated awareness could be also found in"made" actions of schizophrenia, because a patient becomes aware of alien control only after a movement of his body has been caused by external agencies. With regard to this resemblance schizophrenic passivity may be conceived as a disturbance of anchorage in the immediate present. Taking account of an anthropological concept of"life" we elucidate the relationship of the self to the immediate present.
Positive allosteric modulation of the cannabinoid type-1 receptor (CB1R) in periaqueductal gray (PAG) antagonizes anti-nociceptive and cellular effects of a mu-opioid receptor agonist in morphine-withdrawn rats.
Psychopharmacology, 2020

Opioid drugs are a first-line treatment for severe acute pain and other chronic pain conditions, but long-term opioid drug use produces opioid-induced hyperalgesia (OIH). Co-administration of cannabinoids with opioid receptor agonists produce anti-nociceptive synergy, but cannabinoid receptor agonists may also produce undesirable side effects. Therefore, positive allosteric modulators (PAM) of cannabinoid type-1 receptors (CB1R) may provide an option reducing pain and/or enhancing the anti-hyperalgesic effects of opioids without the side effects, tolerance, and dependence observed with the use of ligands that target the orthosteric binding sites. This study tested GAT211, a PAM of cannabinoid type-1 receptors (CB1R), for its ability to enhance the anti-hyperalgesic effects of the mu-opioid receptor (MOR) agonist DAMGO in rats treated chronically with morphine (or saline) and tested during withdrawal. We tested the effects of intra-periaqueductal gray (PAG) injections of (1) DAMGO, (2) GAT211, or (3) DAMGO + GAT211 on thermal nociception in chronic morphine-treated rats that were hyperalgesic and also in saline-treated control rats. We used slice electrophysiology to test the effects of DAMGO/GAT211 bath application on synaptic transmission in the vlPAG. Intra-PAG DAMGO infusions dose-dependently reversed chronic morphine-induced hyperalgesia, but intra-PAG GAT211 did not alter nociception at the doses we tested. When co-administered into the PAG, GAT211 antagonized the anti-nociceptive effects of DAMGO in morphine-withdrawn rats. DAMGO suppressed synaptic inhibition in the vlPAG of brain slices taken from saline- and morphine-treated rats, and GAT211 attenuated DAMGO-induced suppression of synaptic inhibition in vlPAG neurons via actions at CB1R. These findings show that positive allosteric modulation of CB1R antagonizes the behavioral and cellular effects of a MOR agonist in the PAG of rats.
Anterior Cingulate Cortex in Addiction: New Insights for Neuromodulation.
Neuromodulation : journal of the International Neuromodulation Society, 2020

Substance use disorder (SUD) is characterized by compulsive use of addictive substances with considerable impact on both the medical system and society as a whole. The craving of substances leads to relapse in the majority of patients within one year of traditional treatments. In recent decades, neuromodulation approaches have emerged as potential novel treatments of SUD, but the ideal neural target remains contentious.
Two types of somatic spines provide sites for intercellular signaling during calyx of Held growth and maturation.
Synapse (New York, N.Y.), 2021

Dendritic spines have been described in developing and mature systems, but similar extensions from cell bodies are less studied. We utilized electron microscopy image volumes, uniquely collected across a range of early postnatal and month-old mice, to characterize and describe two types of somatic processes that extended into and under the developing calyx of Held (CH), which we named type 1 and type 2 spines. Type 1 spines occurred singly, were mostly vermiform in shape, and formed regularly spaced indentations into the CH. Type 1 spines appeared in concert with the earliest expansion of the CH by P3, peaked at P6 and returned to low density at P30. Type 2 spines were intertwined into a secondary structure called a spine mat, which has not previously been described in the CNS, and were more complex geometrically. Type 2 spines formed after the CH crossed a size threshold, reached maximum density at P9, and were absent from most CHs at P30. Both spine types, but a higher density of type 1 spines, were sites for synapse formation. Spine mats brought pre- and postsynaptic neurons and glial cells into contact, and were captured in stages of partial detachment and engulfment by the presynaptic terminal, suggesting trans-endocytosis as a mode of removal ahead of maturity. In conglomerate, these observations reveal somatic spines to be sites for chemical neurotransmission and chemical sampling among synaptic partners and glia as tissue structure transforms into mature neural circuits.
Hypnotizability, sleepiness, and subjective experience.
The International journal of clinical and experimental hypnosis, 2011

The relationships between hypnotizability, sleepiness, and the subjective experience of hypnotic suggestions were investigated in 90 participants. Scores from the Harvard Group Scale of Hypnotic Susceptibility Form A (HGSHS:A), the Karolinska Sleepiness Scale (KSS), the Epworth Sleepiness Scale (ESS), the Pittsburgh Sleep Quality Index (PSQI), and our self-developed Questionnaire on Subjective Hypnotic Experiences (QSHE) were analyzed. Findings show that hypnotizability correlates with both habitual daytime sleepiness and instantaneous sleepiness after the hypnotic procedure. Results also indicate that subjective self-evaluation of responses to hypnotic suggestions may be a useful tool in some cases when comparing with other subjectively rated scales, such as those concerning sleepiness.
Neuronatin regulates whole-body metabolism: is thermogenesis involved?
FASEB bioAdvances, 2020

Neuronatin (NNAT) was originally discovered in 1995 and labeled as a brain developmental gene due to its abundant expression in developing brains. Over the past 25 years, researchers have uncovered NNAT in other tissues; notably, the hypothalamus, pancreatic β-cells, and adipocytes. Recent evidence in these tissues indicates that NNAT plays a significant role in metabolism whereby it regulates food intake, insulin secretion, and adipocyte differentiation. Furthermore, genetic deletion of
Scale-specific analysis of fMRI data on the irregular cortical surface.
NeuroImage, 2018

To fully characterize the activity patterns on the cerebral cortex as measured with fMRI, the spatial scale of the patterns must be ascertained. Here we address this problem by constructing steerable bandpass filters on the discrete, irregular cortical mesh, using an improved Gaussian smoothing in combination with differential operators of directional derivatives. We demonstrate the utility of the algorithm in two ways. First, using modelling we show that our algorithm yields superior results in numerical precision and spatial uniformity of filter kernels compared to the most widely adopted approach for cortical smoothing. As the effective scales of information differ from the nominal filter sizes applied to extract them, we evaluated the effective scales empirically for different filters to make subsequent comparisons well calibrated. Second, we applied the algorithm to an fMRI dataset to assess the scale and pattern form of cortical encoding of information about visual objects in the ventral visual pathway. We found that filtering by our method improved the detection of discriminant information about experimental conditions over previous methods, that the level of categorization (subordinate versus superordinate) of objects was differentially related to the spatial scale of fMRI patterns, and that the spatial scale at which information was encoded increased along the ventral visual pathway. In sum, our results indicate that the proposed algorithm is particularly suited to assess and detect scale-specific information encoding in cortex, and promises further insight into the topography of cortical encoding in the human brain.
Treatment with endotracheal therapeutics after sarin microinstillation inhalation exposure increases blood cholinesterase levels in guinea pigs.
Toxicology mechanisms and methods, 2012

Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities were measured in the blood and tissues of animals that are treated with a number of endotracheally aerosolized therapeutics for protection against inhalation toxicity to sarin. Therapeutics included, aerosolized atropine methyl bromide (AMB), scopolamine or combination of AMB with salbutamol, sphingosine 1-phosphate, keratinocyte growth factor, adenosine A1 receptor antisense oligonucleotide (EPI2010), 2,3-diacetyloxybenzoic acid (2,3 DABA), oxycyte, and survanta. Guinea pigs exposed to 677.4 mg/m(3) or 846.5 mg/m(3) (1.2 LCt(50)) sarin for 4 min using a microinstillation inhalation exposure technique and treated 1 min later with the aerosolized therapeutics. Treatment with all therapeutics significantly increased the survival rate with no convulsions throughout the 24 h study period. Blood AChE activity determined using acetylthiocholine as substrate showed 20% activity remaining in sarin-exposed animals compare to controls. In aerosolized AMB and scopolamine-treated animals the remaining AChE activity was significantly higher (45-60%) compared to sarin-exposed animals (p < 0.05). Similarly, treatment with all the combination therapeutics resulted in significant increase in blood AChE activity in comparison to sarin-exposed animals although the increases varied between treatments (p < 0.05). BChE activity was increased after treatment with aerosolized therapeutics but was lesser in magnitude compared to AChE activity changes. Various tissues showed elevated AChE activity after therapeutic treatment of sarin-exposed animals. Increased AChE and BChE activities in animals treated with nasal therapeutics suggest that enhanced breathing and reduced respiratory toxicity/lung injury possibly contribute to rapid normalization of chemical warfare nerve agent inhibited cholinesterases.
Laboratory practices to mitigate biohazard risks during the COVID-19 outbreak: an IFCC global survey.
Clinical chemistry and laboratory medicine, 2020

A global survey was conducted by the IFCC Task Force on COVID-19 to better understand how general biochemistry laboratories manage the pre-analytical, analytical and post-analytical processes to mitigate biohazard risks during the coronavirus disease 2019 (COVID-19) pandemic.
The Case for Neuroscience Research in the Classroom.
Neuron, 2019

Neuroscience courses, largely relegated to advanced undergraduate or graduate universities, are now being offered in high schools and middle schools. Low-tech versions of advanced neuroscience research tools are being used in hands-on labs. In this NeuroView, I will argue the need for and provide an overview of neuroscience research beyond academia.
Volatile anesthetic for the control of posthypoxic refractory myoclonic status.
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2016

Posthypoxic myoclonus (Lance-Adams syndrome) is characterized by myoclonus involving multiple muscle groups which is resistant to most conventional antiepileptic drugs. We present a case of hypoxic brain injury-induced myoclonic status epilepticus successfully controlled with isoflurane. The antimyoclonic effects of isoflurane are likely due to potentiation of inhibitory postsynaptic GABAA receptor-mediated currents and its effects on thalamocortical pathways. It is effective even when intravenous agents fail to control myoclonus. It may be a useful alternative to intravenous anesthetics as a third tier therapy in patients with refractory status myoclonus.
Plasma Neurofilament Light as a Biomarker of Neurological Involvement in Wilson's Disease.
Movement disorders : official journal of the Movement Disorder Society, 2021

Outcomes are unpredictable for neurological presentations of Wilson's disease (WD). Dosing regimens for chelation therapy vary and monitoring depends on copper indices, which do not reflect end-organ damage.
Cracking Down on Complexity in the Evolving Brain.
Trends in cognitive sciences, 2019

Louail et al. analyzed the brains of five primate species to determine factors driving size differences. In addition to analyzing the volume of the whole brain, they considered specific brain regions. In doing so, they linked the size of the ventromedial prefrontal cortex with foraging complexity across species.