rudyvdbrink/CitationDatabase huggingface dataset:
The temporal choreography of the yo-yo movement of getting spaghetti into the mouth by the head-fixed mouse.
Behavioural brain research, 2020

There is debate over whether single-handed eating movements, reaching for food and withdrawing the hand to place the food in the mouth, originated in the primate lineage or whether they originated in phylogenetically-earlier Euarchontoglires. Most spontaneous hand use in eating by the laboratory mouse (Mus domestica) involves both hands, and a central question is the extent to which the movements are symmetric. Here we describe an asymmetry of spontaneous single hand use by the head-fixed mouse in making the yo-yo hand movement of removing and replacing a piece of pasta (spaghetti) in the mouth for eating. We also describe the problem/solution of placing into the mouth the end of a held item that protrudes at some distance from the hand. Pasta-eating proceeds in bouts, and a bout starts with raising the hands, which are holding a piece of pasta, to place one end of the pasta in the mouth for biting. A bout ends with lowering the hands, still holding the pasta stem, while the pasta morsel that has been bitten off is chewed. Hand-lowering after the pasta is removed from the mouth is slow, concurrent and symmetric, both when the pasta is held by both hands and when it is held in one hand. Hand-raising to place the pasta in the mouth is fast, consecutive and asymmetric, both when the pasta is held in both hands and when it is held in one hand. Frame-by-frame analyses of the video record combined with kinematic analyses show that a preferred single hand not only directs one end of the pasta to the mouth but also readjusts the trajectory of the pasta if it misses the mouth. The specialized use of a single hand by the mouse, even when the hands are bilaterally engaged, and the corrective asymmetric movements with which one hand adjusts the pasta's trajectory with the other hand playing a supporting role, is discussed in relation to the idea that hand preference, specialization, and dexterity have somatosensory and preprimate origins.
CATSLife: A Study of Lifespan Behavioral Development and Cognitive Functioning.
Twin research and human genetics : the official journal of the International Society for Twin Studies, 2019

The purpose of this update is to provide the most current information about both the Colorado Adoption Project (CAP) and the Longitudinal Twin Study (LTS) and to introduce the Colorado Adoption/Twin Study of Lifespan behavioral development and cognitive aging (CATSLife), a product of their merger and a unique study of lifespan behavioral development and cognitive aging. The primary objective of CATSLife is to assess the unique saliency of early childhood genetic and environmental factors to adult cognitive maintenance and change, as well as proximal influences and innovations that emerge across development. CATSLife is currently assessing up to 1600 individuals on the cusp of middle age, targeting those between 30 and 40 years of age. The ongoing CATSLife data collection is described as well as the longitudinal data available from the earlier CAP and LTS assessments. We illustrate CATSLife via current projects and publications, highlighting the measurement of genetic, biochemical, social, sociodemographic and environmental indices, including geospatial features, and their impact on cognitive maintenance in middle adulthood. CATSLife provides an unparalleled opportunity to assess prospectively the etiologies of cognitive change and test the saliency of early childhood versus proximal influences on the genesis of cognitive decline.
Predictors and Outcomes of Neurological Deterioration in Intracerebral Hemorrhage: Results from the TICH-2 Randomized Controlled Trial.
Translational stroke research, 2021

Neurological deterioration is common after intracerebral hemorrhage (ICH). We aimed to identify the predictors and effects of neurological deterioration and whether tranexamic acid reduced the risk of neurological deterioration. Data from the Tranexamic acid in IntraCerebral Hemorrhage-2 (TICH-2) randomized controlled trial were analyzed. Neurological deterioration was defined as an increase in National Institutes of Health Stroke Scale (NIHSS) of ≥ 4 or a decline in Glasgow Coma Scale of ≥ 2. Neurological deterioration was considered to be early if it started ≤ 48 h and late if commenced between 48 h and 7 days after onset. Logistic regression was used to identify predictors and effects of neurological deterioration and the effect of tranexamic acid on neurological deterioration. Of 2325 patients, 735 (31.7%) had neurological deterioration: 590 (80.3%) occurred early and 145 (19.7%) late. Predictors of early neurological deterioration included recruitment from the UK, previous ICH, higher admission systolic blood pressure, higher NIHSS, shorter onset-to-CT time, larger baseline hematoma, intraventricular hemorrhage, subarachnoid extension and antiplatelet therapy. Older age, male sex, higher NIHSS, previous ICH and larger baseline hematoma predicted late neurological deterioration. Neurological deterioration was independently associated with a modified Rankin Scale of > 3 (aOR 4.98, 3.70-6.70; p < 0.001). Tranexamic acid reduced the risk of early (aOR 0.79, 0.63-0.99; p = 0.041) but not late neurological deterioration (aOR 0.76, 0.52-1.11; p = 0.15). Larger hematoma size, intraventricular and subarachnoid extension increased the risk of neurological deterioration. Neurological deterioration increased the risk of death and dependency at day 90. Tranexamic acid reduced the risk of early neurological deterioration and warrants further investigation in ICH. URL: https://www.isrctn.com Unique identifier: ISRCTN93732214.
Features and functionality of the Iterapi platform for internet-based psychological treatment.
Internet interventions, 2016

The purpose of this article is to describe an internet-based platform for improving symptoms and quality of life for people with psychological and behavioural health problems such as depression, anxiety, phobia, psychological trauma, hearing loss and tinnitus. The online platform, called Iterapi, was developed at the Department of Behavioural Sciences and Learning at Linköping University, Sweden and has been running for nearly two decades and used in many randomized controlled trials and outpatient treatments. The intention of this article is to share our experience with developing such a treatment solution and the process flow and elements of running internet-based psychological interventions. This will likely be of use to developers building similar services, therapists considering integrating such approaches in their practices and institutions, as well as researchers curious about the functions included on the platform and methodology used for running studies. We describe the security aspects of the platform, central concepts underlying its development, how the platform can be used in a study or treatment and the main features and functions the platform offers. We comment on practical considerations regarding blending of methods within the platform, such as self-help treatments with asynchronous communication and real-time text chat and video conversations. We also point out the advantages of using Internet-assisted treatments, the challenges that we have faced and future planned upgrades. Due to continuous development of the platform, its user-friendliness, accessibility across devices and numerous features, many research colleagues from Sweden as well as other countries such as Germany, United Kingdom, Romania and Israel have chosen to implement their own studies on the platform.
A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons.
Scientific reports, 2016

Notch signaling plays crucial roles for cellular differentiation during development through γ-secretase-dependent intramembrane proteolysis followed by transcription of target genes. Although recent studies implicate that Notch regulates synaptic plasticity or cognitive performance, the molecular mechanism how Notch works in mature neurons remains uncertain. Here we demonstrate that a novel Notch signaling is involved in expression of synaptic proteins in postmitotic neurons. Levels of several synaptic vesicle proteins including synaptophysin 1 and VGLUT1 were increased when neurons were cocultured with Notch ligands-expressing NIH3T3 cells. Neuron-specific deletion of Notch genes decreased these proteins, suggesting that Notch signaling maintains the expression of synaptic vesicle proteins in a cell-autonomous manner. Unexpectedly, cGMP-dependent protein kinase (PKG) inhibitor, but not γ-secretase inhibitor, abolished the elevation of synaptic vesicle proteins, suggesting that generation of Notch intracellular domain is dispensable for this function. These data uncover a ligand-dependent, but γ-secretase-independent, non-canonical Notch signaling involved in presynaptic protein expression in postmitotic neurons.
Tissue Engineering 3D Neurovascular Units: A Biomaterials and Bioprinting Perspective.
Trends in biotechnology, 2018

Neurovascular dysfunction is a central process in the pathogenesis of stroke and most neurodegenerative diseases, including Alzheimer's disease. The multicellular neurovascular unit (NVU) combines the neural, vascular and extracellular matrix (ECM) components in an important interface whose correct functioning is critical to maintain brain health. Tissue engineering is now offering new tools and insights to advance our understanding of NVU function. Here, we review how the use of novel biomaterials to mimic the mechanical and functional cues of the ECM, coupled with precisely layered deposition of the different cells of the NVU through 3D bioprinting, is revolutionising the study of neurovascular function and dysfunction.
Violation of eating expectancies does not reduce conditioned desires for chocolate.
Appetite, 2016

Although eating desires can be easily learned, their extinction appears more difficult. The present two-session study aimed to investigate the role of eating expectancies in the short and longer-term extinction of eating desires. In addition, the relationship between eating desires and conditioned evaluations was examined to test whether they might share a similar mechanism. It was hypothesized that the short-term extinction of eating desires would be more successful after the disconfirmation of eating expectancies (instructed extinction or IE), while resulting in worse longer-term extinction because omission of the food reward during extinction is not surprising. In contrast to the hypotheses, it was found that IE had no effect on the short-term and longer-term extinction of eating desires. Eating desires correlated with conditioned evaluations only to some extent. It is concluded that eating expectancies do not mediate the short-term extinction of conditioned eating desires. In addition, their longer-term extinction does not appear to be facilitated by a greater violation of eating expectancies. This suggests that it might not be necessary to focus on expectancy violation in cue exposure therapy to reduce eating desires.
Aneurysm Treatment With Woven EndoBridge in the Cumulative Population of 3 Prospective, Multicenter Series: 2-Year Follow-Up.
Neurosurgery, 2020

Woven EndoBridge (WEB; Sequent Medical) treatment is an innovative endovascular approach for treatment of wide-neck bifurcation aneurysms. Initial studies have shown high safety with good efficacy at short term confirmed by trials conducted in United States (WEB-Intrasaccular Therapy) and in Europe (WEB Clinical Assessment of Intrasaccular Aneurysm Therapy [WEBCAST], French Observatory, and WEBCAST-2).
Sensory and decisional components of endogenous attention are dissociable.
Journal of neurophysiology, 2019

Endogenous cueing of attention enhances sensory processing of the attended stimulus (perceptual sensitivity) and prioritizes information from the attended location for guiding behavioral decisions (spatial choice bias). Here, we test whether sensitivity and bias effects of endogenous spatial attention are under the control of common or distinct mechanisms. Human observers performed a multialternative visuospatial attention task with probabilistic spatial cues. Observers' behavioral choices were analyzed with a recently developed multidimensional signal detection model (the m-ADC model). The model effectively decoupled the effects of spatial cueing on sensitivity from those on spatial bias and revealed striking dissociations between them. Sensitivity was highest at the cued location and not significantly different among uncued locations, suggesting a spotlight-like allocation of sensory resources at the cued location. On the other hand, bias varied systematically with cue validity, suggesting a graded allocation of decisional priority across locations. Cueing-induced modulations of sensitivity and bias were uncorrelated within and across subjects. Bias, but not sensitivity, correlated with key metrics of prioritized decision-making, including reaction times and decision optimality indices. In addition, we developed a novel metric, differential risk curvature, for distinguishing bias effects of attention from those of signal expectation. Differential risk curvature correlated selectively with m-ADC model estimates of bias but not with estimates of sensitivity. Our results reveal dissociable effects of endogenous attention on perceptual sensitivity and choice bias in a multialternative choice task and motivate the search for the distinct neural correlates of each.
A two-dimensional cochlear fluid model based on conformal mapping.
The Journal of the Acoustical Society of America, 2010

Using conformal mapping, fluid motion inside the cochlear duct is derived from fluid motion in an infinite half plane. The cochlear duct is represented by a two-dimensional half-open box. Motion of the cochlear fluid creates a force acting on the cochlear partition, modeled by damped oscillators. The resulting equation is one-dimensional, more realistic, and can be handled more easily than existing ones derived by the method of images, making it useful for fast computations of physically plausible cochlear responses. Solving the equation of motion numerically, its ability to reproduce the essential features of cochlear partition motion is demonstrated. Because fluid coupling can be changed independently of any other physical parameter in this model, it allows the significance of hydrodynamic coupling of the cochlear partition to itself to be quantitatively studied. For the model parameters chosen, as hydrodynamic coupling is increased, the simple resonant frequency response becomes increasingly asymmetric. The stronger the hydrodynamic coupling is, the slower the velocity of the resulting traveling wave at the low frequency side is. The model's simplicity and straightforward mathematics make it useful for evaluating more complicated models and for education in hydrodynamics and biophysics of hearing.
Motivation for sucrose in sated rats is predicted by low anxiety-like behavior.
Neuroscience letters, 2009

Anxiety has been implicated in obesity and in the overconsumption of highly palatable foods such as those high in fat, sugar, or both. Also, the novelty-seeking trait has been associated with failure in weight-loss programs. The aim of this study was to investigate the associations of experimental anxiety and the self-administration of sucrose and high fat pellets in non-food deprived rats across different operant schedules. Male Wistar rats were subjected to the elevated plus-maze test (EPM) of anxiety-like behavior. The rats were tested for fixed ratio 5 (FR5) and progressive ratio (PR) operant responding for 50% sucrose, 95% sucrose, and high-fat pellets. PR active lever press response for 95% sucrose, but not the other pellet types, was correlated to % time spent on open arms (P=0.019) in the EPM. On the FR5 schedule, activity (closed arm entries) was correlated to the self-administration of 50% sucrose (P=0.027) and high-fat (P=0.002). This indicates an association of novelty-induced activity and self-administration of palatable food in sated rats, as well as a specific association of PR lever press response for 95% sucrose and low anxiety-like behavior. It has been argued that such active lever press response on PR may be interpreted as craving for the reinforcer; thus, our findings indicate an inverse relationship of experimental anxiety and craving for sucrose. This connection may have implications for human situations, since anxiety and novelty-seeking have been associated with obesity and failure in weight-loss programs.
Frontal eye field neurons signal changes in decision criteria.
Nature neuroscience, 2009

Flexible links between sensory stimuli and behavioral responses underlie many cognitive processes. One process that contributes to flexible decision-making is categorization. Some categories are innate or overlearned, but, in many cases, category boundaries represent flexible decision criteria that can shift on the fly to adapt to changes in the environment. The ability to shift category boundaries allows decision-making to adapt to changing circumstances. We found that monkeys were able to switch rapidly between two category boundaries when classifying the speed of a moving dot pattern and that neurons in monkey frontal eye field (FEF) changed their activity when the boundary changed. The responses of a subpopulation of FEF neurons that were sensitive to both stimulus and boundary speed were used to classify the stimuli as accurately as the monkeys' performance.
LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation.
Experimental neurobiology, 2018

Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease (PD). LRRK2 contains a functional kinase domain and G2019S, the most prevalent LRRK2 pathogenic mutation, increases its kinase activity. LRRK2 regulates mitochondria morphology and autophagy in neurons. LPS treatment increases LRRK2 protein level and mitochondrial fission in microglia, and down-regulation of LRRK2 expression or inhibition of its kinase activity attenuates microglia activation. Here, we evaluated the direct role of LRRK2 G2019S in mitochondrial dynamics in microglia. Initial observation of microglia in G2019S transgenic mice revealed a decrease in mitochondrial area and shortage of microglial processes compared with their littermates. Next, we elucidated the molecular mechanisms of these phenotypes. Treatment of BV2 cells and primary microglia with LPS enhanced mitochondrial fission and increased Drp1, a mitochondrial fission marker, as previously reported. Importantly, both phenotypes were rescued by treatment with GSK2578215A, a LRRK2 kinase inhibitor. Finally, the protein levels of CD68, an active microglia marker, Drp1 and TNF-α were significantly higher in brain lysates of G2019S transgenic mice compared with the levels in their littermates. Taken together, our data suggest that LRRK2 could promote microglial mitochondrial alteration via Drp1 in a kinase-dependent manner, resulting in stimulation of pro-inflammatory responses. This mechanism in microglia might be a potential target to develop PD therapy since neuroinflammation by active microglia is a major symptom of PD.
Dual brain stimulation enhances interpersonal learning through spontaneous movement synchrony.
Social cognitive and affective neuroscience, 2021

Social interactive learning denotes the ability to acquire new information from a conspecific-a prerequisite for cultural evolution and survival. As inspired by recent neurophysiological research, here we tested whether social interactive learning can be augmented by exogenously synchronizing oscillatory brain activity across an instructor and a learner engaged in a naturalistic song-learning task. We used a dual brain stimulation protocol entailing the trans-cranial delivery of synchronized electric currents in two individuals simultaneously. When we stimulated inferior frontal brain regions, with 6 Hz alternating currents being in-phase between the instructor and the learner, the dyad exhibited spontaneous and synchronized body movement. Remarkably, this stimulation also led to enhanced learning performance. These effects were both phase- and frequency-specific: 6 Hz anti-phase stimulation or 10 Hz in-phase stimulation, did not yield comparable results. Furthermore, a mediation analysis disclosed that interpersonal movement synchrony acted as a partial mediator of the effect of dual brain stimulation on learning performance, i.e. possibly facilitating the effect of dual brain stimulation on learning. Our results provide a causal demonstration that inter-brain synchronization is a sufficient condition to improve real-time information transfer between pairs of individuals.
Layer specificity of inputs from supplementary motor area and dorsal premotor cortex to primary motor cortex in macaque monkeys.
Scientific reports, 2019

The primate frontal lobe processes diverse motor information in parallel through multiple motor-related areas. For example, the supplementary motor area (SMA) is mainly involved in internally-triggered movements, whereas the premotor cortex (PM) is highly responsible for externally-guided movements. The primary motor cortex (M1) deals with both aspects of movements to execute a single motor behavior. To elucidate how the cortical motor system is structured to process a variety of information, the laminar distribution patterns of signals were examined between SMA and M1, or PM and M1 in macaque monkeys by using dual anterograde tract-tracing. Dense terminal labeling was observed in layers 1 and upper 2/3 of M1 after one tracer injection into SMA, another tracer injection into the dorsal division of PM resulted in prominent labeling in the deeper portion of layer 2/3. Weaker labeling was also visible in layer 5 in both cases. On the other hand, inputs from M1 terminated in both the superficial and the deep layers of SMA and PM. The present data indicate that distinct types of motor information are arranged in M1 in a layer-specific fashion to be orchestrated through a microcircuit within M1.
Diversity and wiring variability of olfactory local interneurons in the Drosophila antennal lobe.
Nature neuroscience, 2010

Local interneurons are essential in information processing by neural circuits. Here we present a comprehensive genetic, anatomical and electrophysiological analysis of local interneurons (LNs) in the Drosophila melanogaster antennal lobe, the first olfactory processing center in the brain. We found LNs to be diverse in their neurotransmitter profiles, connectivity and physiological properties. Analysis of >1,500 individual LNs revealed principal morphological classes characterized by coarsely stereotyped glomerular innervation patterns. Some of these morphological classes showed distinct physiological properties. However, the finer-scale connectivity of an individual LN varied considerably across brains, and there was notable physiological variability within each morphological or genetic class. Finally, LN innervation required interaction with olfactory receptor neurons during development, and some individual variability also likely reflected LN-LN interactions. Our results reveal an unexpected degree of complexity and individual variation in an invertebrate neural circuit, a result that creates challenges for solving the Drosophila connectome.