rudyvdbrink/CitationDatabase huggingface dataset:
[Neural Basis of "Breath of Aun"].
Brain and nerve = Shinkei kenkyu no shinpo, 2020

Many musical expressions exist in various cultures of the world, where multiple performers autonomously synchronize without a conductor or a metronome, and achieve an undisturbed musical performance by "breath of Aun". As a typical example, we considered the ritual performing art of Kecak in Bali, Indonesia, and performed simultaneous electroencephalogram (EEG) measurements on multiple participants during a Kecak performance. The study revealed that the inter-individual synchronization of the EEG during and after the performance was enhanced as compared to that before the performance. The author will also discuss the relation between synchronization of brain function and society and the culture of Bali.
Neuroscience: Sensing Absolute Cold.
Current biology : CB, 2020

To overwinter, animals must detect constant cold temperatures before adapting their behavior accordingly. A new study in Drosophila describes a circuit mechanism - from sensory neurons to higher brain centers - that encodes and relays persistent, absolute cold stimuli to modulate sleep.
Illusory displacement due to object substitution near the consciousness threshold.
Journal of vision, 2008

A briefly presented target shape can be made invisible by the subsequent presentation of a mask that replaces the target. While varying the target-mask interval in order to investigate perception near the consciousness threshold, we discovered a novel visual illusion. At some intervals, the target is clearly visible, but its location is misperceived. By manipulating the mask's size and target's position, we demonstrate that the perceived target location is always displaced to the boundary of a virtual surface defined by the mask contours. Thus, mutual exclusion of surfaces appears as a cause of masking.
Glutamatergic Neurons of the Paraventricular Nucleus are Critical for the Control of Wakefulness.
Neuroscience, 2020

Normal sleep-wake behavior is extremely important for humans to maintain basic physiological and cognitive activities. However, the neural mechanisms underlying sleep-wake regulation are not fully understood. The paraventricular nucleus (PVN) of the hypothalamus has been classically defined as a region for the regulation of the hypothalamoneurohypophysial system and autonomic nervous system. Here, we identify the glutamatergic neurons in the PVN that play a unique role in sleep-wake regulation. Firstly using in vivo fiber photometry, we found altered calcium activities of PVN glutamatergic neurons during three sleep state transitions in freely behaving mice. The calcium activities of PVN glutamatergic neurons began to increase before non-rapid-eye movement (NREM) sleep to wake transitions and NREM sleep to rapid-eye-movement (REM) sleep transitions and began to decrease before wake to NREM sleep transitions. Then we used chemogenetic manipulations together with polysomnographic recordings, activation of PVN neurons increased wakefulness and decreased NREM sleep, while inhibition of PVN neurons caused a reduction in wakefulness and an increase in NREM sleep. Altogether, our findings revealed an important role for PVN glutamatergic neurons in the regulation of wake state.
The developmental neural substrates of Hebb repetition learning and their link with reading ability.
Human brain mapping, 2020

Hebb repetition learning is a fundamental learning mechanism for sequential knowledge, such as language. However, still little is known about its development. This fMRI study examined the developmental neural substrates of Hebb repetition learning and its relation with reading abilities in a group of 49 children aged from 6 to 12 years. In the scanner, the children carried out an immediate serial recall task for syllable sequences of which some sequences were repeated several times over the course of the session (Hebb repetition sequences). The rate of Hebb repetition learning was associated with modulation of activity in the medial temporal lobe. Importantly, for the age range studied here, learning-related medial temporal lobe modulation was independent of the age of the children. Furthermore, we observed an association between regular and irregular word reading abilities and the neural substrates of Hebb repetition learning. This study suggests that the functional neural substrates of Hebb repetition learning do not undergo further maturational changes in school age children, possibly because they are sustained by implicit sequential learning mechanisms which are considered to be fully developed by that age. Importantly, the neural substrates of Hebb learning remain significant determinants of children's learning abilities, such as reading.
Improving Prediction of Favourable Outcome After 6 Months in Patients with Severe Traumatic Brain Injury Using Physiological Cerebral Parameters in a Multivariable Logistic Regression Model.
Neurocritical care, 2020

Current severe traumatic brain injury (TBI) outcome prediction models calculate the chance of unfavourable outcome after 6 months based on parameters measured at admission. We aimed to improve current models with the addition of continuously measured neuromonitoring data within the first 24 h after intensive care unit neuromonitoring.
Parent-child communication and timing of interventions are challenges in the Duchenne muscular dystrophy care.
Acta paediatrica (Oslo, Norway : 1992), 2019

Duchenne muscular dystrophy (DMD) is an X-linked myopathy affecting one in 3600-6000 live male births. The aim of this study was to gain further insight into how parents experience caring for boys with DMD.
Genetic underpinnings of schizophrenia-related electroencephalographical intermediate phenotypes: A systematic review and meta-analysis.
Progress in neuro-psychopharmacology & biological psychiatry, 2021

Although substantial research into genetics of psychotic disorders has been conducted, a large proportion of their genetic architecture has remained unresolved. Electroencephalographical intermediate phenotypes (EIP) have the potential to constitute a valuable tool when studying genetic risk loci for schizophrenia, in particular P3b amplitude, P50 suppression, mismatch negativity (MMN) and resting state power spectra of the electroencephalogram (EEG). Here, we systematically reviewed studies investigating the association of single nucleotide polymorphisms (SNPs) with these EIPs and meta-analysed them when appropriate. We retrieved 45 studies (N = 34,971 study participants). Four SNPs investigated in more than one study were genome-wide significant for an association with schizophrenia and three were genome-wide suggestive, based on a lookup in the influential 2014 GWAS (Ripke et al., 2014). However, in our meta-analyses, rs1625579 failed to reach a statistically significant association with p3b amplitude decrease and rs4680 risk allele carrier status was not associated with p3b amplitude decrease or with impaired p50 suppression. In conclusion, evidence for SNP associations with EIPs remains limited to individual studies. Careful selection of EIPs and SNPs, combined with consistent reporting of effect sizes, directions of effect and p-values would aid future meta-analyses.
Positron Emission Tomography for the Development and Characterization of Corneal Permanence of Ophthalmic Pharmaceutical Formulations.
Investigative ophthalmology & visual science, 2017

This work is aimed at describing the utility of positron emission tomography/computed tomography (PET/CT) as a noninvasive tool for pharmacokinetic studies of biopermanence of topical ocular formulations.
Immersive virtual reality reveals that visuo-proprioceptive discrepancy enlarges the hand-centred peripersonal space.
Neuropsychologia, 2020

Vision and proprioception, informing the system about the body position in space, seem crucial in defining the boundary of the peripersonal space (PPS). What happens to the PPS representation when a conflict between vision and proprioception arises? We capitalize on the Immersive Virtual Reality to dissociate vision and proprioception by presenting the participants' 3D hand image in congruent/incongruent positions with respect to the participants' real hand. To measure the hand-centred PPS, we exploit multisensory integration occurring when visual stimuli are delivered simultaneously with tactile stimuli applied to a body district; i.e., visual enhancement of touch (VET). Participants are instructed to respond to tactile stimuli while ignoring visual stimuli (red LED), which can appear either near to or far from the hand receiving tactile (electrical) stimuli. The results show that, when vision and proprioception are congruent (i.e., real and virtual hand coincide), a space-dependent modulation of the VET effect occurs (with faster responses when visual stimuli are near to than far from the stimulated hand). Contrarily, when vision and proprioception are incongruent (i.e., a discrepancy between real and virtual hand is present), a comparable VET effect is observed when visual stimuli occur near to the real hand and when they occur far from it, but close to the virtual hand. These findings, also confirmed by the independent estimate of a Bayesian Causal Inference model, suggest that, when the visuo-proprioceptive discrepancy makes the coding of the hand position less precise, the hand-centred PPS is enlarged, likely to optimize reactions to external events.
Trevor W. Robbins: Award for Distinguished Scientific Contributions.
The American psychologist, 2011

Presents Trevor W. Robbins, the 2011 winner of the American Psychological Association Award for Distinguished Scientific Contributions."For distinguished theoretical and empirical contributions to basic research in experimental psychology and neuroscience. Trevor W. Robbins has made innovative and landmark contributions to understanding monoaminergic and glutamatergic regulation of cortico-striatal-limbic function and its involvement in psychological processes and pathological states such as addiction, depression, schizophrenia, and attention-deficit/hyperactivity disorder. His pioneering accomplishments have included the development of methodologies for parallel sophisticated behavioral assessments in humans, rodents, and monkeys combined with psychopharmacological and imaging studies across species. His vigor and dedication to research, exemplary leadership, scholarship, and stellar productivity have advanced our knowledge of brain function and inspired several generations of cognitive neuroscientists." (PsycINFO Database Record (c) 2011 APA, all rights reserved).
Research priorities for the COVID-19 pandemic and beyond: A call to action for psychological science.
British journal of psychology (London, England : 1953), 2020

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that has caused the coronavirus disease 2019 (COVID-19) pandemic represents the greatest international biopsychosocial emergency the world has faced for a century, and psychological science has an integral role to offer in helping societies recover. The aim of this paper is to set out the shorter- and longer-term priorities for research in psychological science that will (a) frame the breadth and scope of potential contributions from across the discipline; (b) enable researchers to focus their resources on gaps in knowledge; and (c) help funders and policymakers make informed decisions about future research priorities in order to best meet the needs of societies as they emerge from the acute phase of the pandemic. The research priorities were informed by an expert panel convened by the British Psychological Society that reflects the breadth of the discipline; a wider advisory panel with international input; and a survey of 539 psychological scientists conducted early in May 2020. The most pressing need is to research the negative biopsychosocial impacts of the COVID-19 pandemic to facilitate immediate and longer-term recovery, not only in relation to mental health, but also in relation to behaviour change and adherence, work, education, children and families, physical health and the brain, and social cohesion and connectedness. We call on psychological scientists to work collaboratively with other scientists and stakeholders, establish consortia, and develop innovative research methods while maintaining high-quality, open, and rigorous research standards.
Individual variations lead to universal and cross-species patterns of social behavior.
Proceedings of the National Academy of Sciences of the United States of America, 2020

The duration of interaction events in a society is a fundamental measure of its collective nature and potentially reflects variability in individual behavior. Here we performed a high-throughput measurement of trophallaxis and face-to-face event durations experienced by a colony of honeybees over their entire lifetimes. The interaction time distribution is heavy-tailed, as previously reported for human face-to-face interactions. We developed a theory of pair interactions that takes into account individual variability and predicts the scaling behavior for both bee and extant human datasets. The individual variability of worker honeybees was nonzero but less than that of humans, possibly reflecting their greater genetic relatedness. Our work shows how individual differences can lead to universal patterns of behavior that transcend species and specific mechanisms for social interactions.
Characterising the hippocampal response to perception, construction and complexity.
Cortex; a journal devoted to the study of the nervous system and behavior, 2021

The precise role played by the hippocampus in supporting cognitive functions such as episodic memory and future thinking is debated, but there is general agreement that it involves constructing representations comprised of numerous elements. Visual scenes have been deployed extensively in cognitive neuroscience because they are paradigmatic multi-element stimuli. However, questions remain about the specificity and nature of the hippocampal response to scenes. Here, we devised a paradigm in which we had participants search pairs of images for either colour or layout differences, thought to be associated with perceptual or spatial constructive processes respectively. Importantly, images depicted either naturalistic scenes or phase-scrambled versions of the same scenes, and were either simple or complex. Using this paradigm during functional MRI scanning, we addressed three questions: 1. Is the hippocampus recruited specifically during scene processing? 2. If the hippocampus is more active in response to scenes, does searching for colour or layout differences influence its activation? 3. Does the complexity of the scenes affect its response? We found that, compared to phase-scrambled versions of the scenes, the hippocampus was more responsive to scene stimuli. Moreover, a clear anatomical distinction was evident, with colour detection in scenes engaging the posterior hippocampus whereas layout detection in scenes recruited the anterior hippocampus. The complexity of the scenes did not influence hippocampal activity. These findings seem to align with perspectives that propose the hippocampus is especially attuned to scenes, and its involvement occurs irrespective of the cognitive process or the complexity of the scenes.
Resting Brain Fluctuations Are Intrinsically Coupled to Visual Response Dynamics.
Cerebral cortex (New York, N.Y. : 1991), 2021

How do intrinsic brain dynamics interact with processing of external sensory stimuli? We sought new insights using functional magnetic resonance imaging to track spatiotemporal activity patterns at the whole brain level in lightly anesthetized mice, during both resting conditions and visual stimulation trials. Our results provide evidence that quasiperiodic patterns (QPPs) are the most prominent component of mouse resting brain dynamics. These QPPs captured the temporal alignment of anticorrelation between the default mode (DMN)- and task-positive (TPN)-like networks, with global brain fluctuations, and activity in neuromodulatory nuclei of the reticular formation. Specifically, the phase of QPPs prior to stimulation could significantly stratify subsequent visual response magnitude, suggesting QPPs relate to brain state fluctuations. This is the first observation in mice that dynamics of the DMN- and TPN-like networks, and particularly their anticorrelation, capture a brain state dynamic that affects sensory processing. Interestingly, QPPs also displayed transient onset response properties during visual stimulation, which covaried with deactivations in the reticular formation. We conclude that QPPs appear to capture a brain state fluctuation that may be orchestrated through neuromodulation. Our findings provide new frontiers to understand the neural processes that shape functional brain states and modulate sensory input processing.
Inverse autonomic stress reactivity in depressed patients with and without prior history of depression.
Journal of psychiatric research, 2020

There is a considerable association between major depressive disorder (MDD) and cardiovascular disease, most possibly relying on abnormalities in the autonomic nervous system (ANS)-related cardiac reactivity, although the exact underlying pathophysiological pathway is unclear. This study tends to shed some additional light on this background by investigating ANS reactivity in MDD with respect to previous depression history through an objective stress challenge paradigm.
Mirror representations innate versus determined by experience: a viewpoint from learning theory.
The Behavioral and brain sciences, 2014

From the viewpoint of pattern recognition and computational learning, mirror neurons form an interesting multimodal representation that links action perception and planning. While it seems unlikely that all details of such representations are specified by the genetic code, robust learning of such complex representations likely requires an appropriate interplay between plasticity, generalization, and anatomical constraints of the underlying neural architecture.
Cannabinoid receptor Type 1 densities reflect social organization in Microtus.
The Journal of comparative neurology, 2021

Across many species, endocannabinoids play an important role in regulating social play, reward, and anxiety. These processes are mediated through at least two distinct cannabinoid receptors (CB), CB1 and CB2. CB1 expression is found in appreciable densities across regions of the brain that integrate memory with socio-spatial information; many of these regions have been directly linked to the neurobiology of pair bonding in monogamous species. Using receptor autoradiography, we provide the first distributional map of CB1 within the brains of closely related monogamous prairie voles and promiscuous meadow voles, and compare receptor densities across sexes and species in limbic regions. We observe CB1-specific signal using [3H] CP-55,940 and [3H] SR141716A, though the latter exhibited a lower signal to noise ratio. We confirmed the presence of CB2 in prairie vole spleen tissue using [3H] CP-55,940. However, we found no evidence of CB2 in the brain using either [3H] CP-55,940 or [3H] A-836,339. The overall distribution of putative CB1 in the brain was similar across vole species and followed the pattern of CB1 expression observed in other species-high intensity binding within the telencephalon, moderate binding within the diencephalon, and mild binding within the mesencephalon and metencephalon (aside from the cerebellar cortex). However, we found profound differences in CB1 densities across species, with prairie voles having higher CB1 binding in regions implicated in social attachment and spatial memory (e.g., periaqueductal gray, hippocampus). These findings suggest that CB1 densities, but not distribution, correlate with the social systems of vole species.
Insights into microbiome research 4: The computational analysis.
Multiple sclerosis (Houndmills, Basingstoke, England), 2019

The computational analysis of microbiome samples is a highly specialized task, requiring powerful hardware and deep know-how not only in informatics and statistics but also in ecology and taxonomy. Different approaches must be followed based on the sequencing method (16S or shotgun) and while these can provide partially overlapping information, they are conceptually distinct. Understanding their differences and similarities can be useful in the interpretation of the results of microbiome studies.
Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping.
Journal of visualized experiments : JoVE, 2019

The Translational Brain Mapping Program at the University of Rochester is an interdisciplinary effort that integrates cognitive science, neurophysiology, neuroanesthesia, and neurosurgery. Patients who have tumors or epileptogenic tissue in eloquent brain areas are studied preoperatively with functional and structural MRI, and intraoperatively with direct electrical stimulation mapping. Post-operative neural and cognitive outcome measures fuel basic science studies about the factors that mediate good versus poor outcome after surgery, and how brain mapping can be further optimized to ensure the best outcome for future patients. In this article, we describe the interdisciplinary workflow that allows our team to meet the synergistic goals of optimizing patient outcome and advancing scientific understanding of the human brain.
Profound and redundant functions of arcuate neurons in obesity development.
Nature metabolism, 2020

The current obesity epidemic faces a lack of mechanistic insights. It is known that the acute activity changes of a growing number of brain neurons rapidly alter feeding behaviour; however, how these changes translate to obesity development and the fundamental mechanism underlying brain neurons in controlling body weight remain elusive. Here, we show that chronic activation of hypothalamic arcuate GABAergic (GABA
Differential anxiety-like responses in NOD/ShiLtJ and C57BL/6J mice following experimental autoimmune encephalomyelitis induction and oral gavage.
Laboratory animals, 2018

Oral gavage is commonly used in pre-clinical drug evaluation, but is potentially aversive and may induce behavioral effects independent of compounds under investigation. This study examined the combined effects of repeated oral gavage and disease induction on anxiety-like behavior in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis. The C57BL/6J and NOD/ShiLtJ EAE variants were exposed to sham-EAE induction or untreated control conditions, and either daily oral gavage or home cage conditions. Anxiety-like behavior was subsequently assessed in the elevated plus maze. C57BL/6J mice exhibited increased anxiety-like behavior, relative to NOD/ShiLtJ mice, in response to repeated gavage, whereas sham-EAE induction and repeated gavage were associated with increased anxiety-like behavior in NOD/ShiLtJ mice. Thus, exposure to the induction procedure and repeated gavage differentially altered subsequent anxiety-like behavior in the two EAE variants. Future pre-clinical studies should rely on prior evaluation of parameters of the experimental design using sham-EAE mice. Additionally, less aversive administration routes should be utilized wherever possible to ensure that procedures do not distort effects of the therapeutic under investigation.
Imbalance of laminar-specific excitatory and inhibitory circuits of the orbitofrontal cortex in autism.
Molecular autism, 2020

The human orbitofrontal cortex (OFC) is involved in assessing the emotional significance of events and stimuli, emotion-based learning, allocation of attentional resources, and social cognition. Little is known about the structure, connectivity and excitatory/inhibitory circuit interactions underlying these diverse functions in human OFC, as well as how the circuit is disrupted in individuals with autism spectrum disorder (ASD).