rudyvdbrink/CitationDatabase huggingface dataset:
Prosocial behavior as sexual signaling.
The Behavioral and brain sciences, 2017

Maestripieri et al. provide an important service in highlighting prosocial biases toward attractive people from a cross-disciplinary perspective. Here I comment on the conceptual and critical side of their review of evolutionary psychology studies. I propose that further work should be focused on understanding the role of signaling in prosocial behavior.
Functional circuits and signal processing in the enteric nervous system.
Cellular and molecular life sciences : CMLS, 2020

The enteric nervous system (ENS) is an extensive network comprising millions of neurons and glial cells contained within the wall of the gastrointestinal tract. The major functions of the ENS that have been most studied include the regulation of local gut motility, secretion, and blood flow. Other areas that have been gaining increased attention include its interaction with the immune system, with the gut microbiota and its involvement in the gut-brain axis, and neuro-epithelial interactions. Thus, the enteric circuitry plays a central role in intestinal homeostasis, and this becomes particularly evident when there are faults in its wiring such as in neurodevelopmental or neurodegenerative disorders. In this review, we first focus on the current knowledge on the cellular composition of enteric circuits. We then further discuss how enteric circuits detect and process external information, how these signals may be modulated by physiological and pathophysiological factors, and finally, how outputs are generated for integrated gut function.
[Antecedent Infections in Guillain-Barré Syndrome: Knowledge in Clinical Practice].
Brain and nerve = Shinkei kenkyu no shinpo, 2015

Guillain-Barré syndrome (GBS) is a post-infectious disease in which a diversity of pathogenetic factors and clinical features is surely determined by the type of preceding infections. It is necessary in clinical practice and research to identify the antecedent infectious agent in each case. Several lines of evidence indicate that the ganglioside-like epitopes on the infectious agents induce the production of anti-ganglioside autoantibodies and thereby cause GBS. This makes it possible to evaluate the causal significance of the pathogen by examining the cross-reactivity of the detected autoantibodies with outer antigens of the pathogens, although such an investigation is practical only when the pathogen is successfully isolated from the patients. The term "antecedent infection" should be strictly used in the situation in which the infection is thought to be closely related to the development of GBS but not for the situation without findings that suggest such a relationship. Simple but non-validated criteria for the judgment of antecedent infection in each GBS case are proposed in this review in order to prevent numerous and unreliable suspicions of "new" and "unknown" prior infectious agents of GBS, which are only built on the precedence in the disease.
Mapping the Internal Anatomy of the Lateral Brainstem: Anatomical Study with Application to Far Lateral Approaches to Intrinsic Brainstem Tumors.
Cureus, 2017

Intramedullary brainstem tumors present a special challenge to the neurosurgeon. Unfortunately, there is no ideal part of the brainstem to incise for approaches to such pathology. Therefore, the present study was performed to identify what incisions on the lateral brainstem would result in the least amount of damage to eloquent tracts and nuclei. Case illustrations are also discussed.
β2-Adrenergic Receptor Stimulation Upregulates Cx43 Expression on Glioblastoma Multiforme and Olfactory Ensheathing Cells.
Journal of molecular neuroscience : MN, 2020

Glioblastoma multiforme (GBM) is described as an invasive astrocytic tumor in adults. Despite current standard treatment approaches, the outcome of GBM remains unfavorable. The downregulation of connexin 43 (Cx43) expression is one of the molecular transformations in GBM cells. The Cx43 levels and subsequently gap junctional intercellular communication (GJIC) have an important role in the efficient transfer of cytotoxic drugs to whole tumor cells. As shown in our previous study, the stimulation of the β2-adrenergic receptor (β2-AR) leads to the modulation of Cx43 expression level in the GBM cell line. Here we further examine the effect of clenbuterol hydrochloride as a selective β2-AR agonist on the Cx43 expression in human GBM-derived astrocyte cells and human olfactory ensheathing cells (OECs) as a potent vector for future gene therapy. In this experiment, first we established a primary culture of astrocytes from GBM samples and verified the purity using immunocytofluorescent staining. Western blot analysis was performed to evaluate the Cx43 protein level. Our western blot findings reveal that clenbuterol hydrochloride upregulates the Cx43 protein level in both primary human astrocyte cells and human OECs. Conversely, ICI 118551 as a β2-AR antagonist inhibits these effects. Moreover, clenbuterol hydrochloride increases the Cx43 expression in primary human astrocyte cells and OECs co-culture systems, and ICI 118551 reverses these effects. To confirm the western blot results, immunocytofluorescent staining was performed to evaluate the β2-AR agonist effect on Cx43 expression. Our immunocytofluorescent results supported western blot analysis in primary human astrocyte cells and the OECs co-culture system. The results of this study suggest that the activation of β2-AR with regard to Cx43 protein levels enhancement in GBM cells and OECs might be a promising approach for GBM treatment in the future.
Evidence of association between obesity and lower cerebral myelin content in cognitively unimpaired adults.
International journal of obesity (2005), 2021

Myelin loss is a central feature of several neurodegenerative diseases, including Alzheimer's disease (AD). In animal studies, a link has been established between obesity and impairment of oligodendrocyte maturation, the cells that produce and maintain myelin. Although clinical magnetic resonance imaging (MRI) studies have revealed microstructural alterations of cerebral white matter tissue in subjects with obesity, no specific myelin vs. obesity correlation studies have been performed in humans using a direct myelin content metric.
Clock-Controlled Mitochondrial Dynamics Correlates with Cyclic Pregnenolone Synthesis.
Cells, 2020

Neurosteroids are steroids synthetized in the nervous system, with the first step of steroidogenesis taking place within mitochondria with the synthesis of pregnenolone. They exert important brain-specific functions by playing a role in neurotransmission, learning and memory processes, and neuroprotection. Here, we show for the first time that mitochondrial neurosteroidogenesis follows a circadian rhythm and correlates with the rhythmic changes in mitochondrial morphology. We used synchronized human A172 glioma cells, which are steroidogenic cells with a functional core molecular clock, to show that pregnenolone levels and translocator protein (TSPO) are controlled by the clock, probably via circadian regulation of mitochondrial fusion/fission. Key findings were recapitulated in mouse brains. We also showed that genetic or pharmacological abrogation of fusion/fission activity, as well as disturbing the core molecular clock, abolished circadian rhythms of pregnenolone and TSPO. Our findings provide new insights into the crosstalk between mitochondrial function (here, neurosteroidogenesis) and circadian cycles.
Influence of mandibular advancement on tongue dilatory movement during wakefulness and how this is related to oral appliance therapy outcome for obstructive sleep apnea.
Sleep, 2021

To characterize how mandibular advancement splint (MAS) alters inspiratory tongue movement in people with obstructive sleep apnea (OSA) during wakefulness and whether this is associated with MAS treatment outcome.
SMILE: a predictive model for Scoring the severity of relapses in MultIple scLErosis.
Journal of neurology, 2021

In relapsing-remitting multiple sclerosis (RRMS), relapse severity and residual disability are difficult to predict. Nevertheless, this information is crucial both for guiding relapse treatment strategies and for informing patients.
The Orphan Nuclear Receptor TLX Is a Receptor for Synthetic and Natural Retinoids.
Cell chemical biology, 2020

TLX is an orphan nuclear receptor that plays a critical role in both embryonic and adult neurogenesis, as well in the pathogenesis of glioblastomas. TLX functions predominately as a transcriptional repressor, but no natural ligands or high-affinity synthetic ligands have been identified. Here, we describe the identification of natural and synthetic retinoids as functional ligands for TLX. We identified potent synthetic retinoids that directly bind to TLX and either activate or inhibit its transcriptional repressor activity. Furthermore, we identified all-trans and 11-cis retinaldehyde (retinal), retinoids that play an essential role in the visual cycle, as the preferential natural retinoids that bind to and modulate the function of TLX. Molecular dynamics simulations followed by mutational analysis provided insight into the molecular basis of retinoid binding to TLX. Our data support the validity of TLX as a target for development of therapeutics to treat cognitive disorders and/or glioblastomas.
Development and Preliminary Validation of Standardized Regression-Based Change Scores as Measures of Transitional Cognitive Decline.
Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 2020

An increasing focus in Alzheimer's disease and aging research is to identify transitional cognitive decline. One means of indexing change over time in serial cognitive evaluations is to calculate standardized regression-based (SRB) change indices. This paper includes the development and preliminary validation of SRB indices for the Uniform Data Set 3.0 Neuropsychological Battery, as well as base rate data to aid in their interpretation.
Kainic acid Induces production and aggregation of amyloid β-protein and memory deficits by activating inflammasomes in NLRP3- and NF-κB-stimulated pathways.
Aging, 2019

Kainic acid (KA) treatment causes neuronal degeneration, which is a feature of Alzheimer's disease (AD) symptoms such as amyloid β-protein production and memory deficits. Inflammasomes are known to be critical for the progression of AD. However, the underlying mechanism by which inflammasomes influence AD progression remains unknown. The present study investigated the damaging effect of KA on neurons by focusing on the inflammasome-mediated signaling pathways. Assessments using cultured microglia and mouse brains demonstrated that KA treatment specifically induced inflammasome activation. Mechanistic evaluations showed that KA activated two major components of inflammasomes, nucleotide binding oligomerization domain (NOD)-like receptor (NLR) protein 3 (NLRP3) and nuclear factor (NF)-κB, which resulted in the production of interleukin-1β (IL-1β) and brain-derived neurotrophic factor (BDNF). Inhibition of NLRP3 or NF-κB by Bay11-7082 caused a reduction in the KA-induced expression of interleukin (IL)-1β and BDNF. Moreover, knockdown of the expression of KA receptors (KARs) such as Grik1 and Grik3 induced suppression of NLRP3 and NF-κB, suggesting that KARs function upstream of NLRP3 and NF-κB to mediate the effects of KA on regulation of IL-1β and BDNF expression. Notably, IL-1β was shown to exert positive effects on the expression of BACE1, which is blocked by Bay11-7082. Overall, our results revealed that Bay11-7082 acts against KA-induced neuronal degeneration, amyloid β-protein (Aβ) deposition, and memory defects via inflammasomes and further highlighted the protective role of Bay11-7082 in KA-induced neuronal defects.
Ankle control differentiation as a mechanism for mobility limitations.
Neuroscience letters, 2020

Independent control of the right and left ankles (differentiation) may be a motor control mechanism linking impaired coordination and mobility limitations. We tested the hypotheses that motor control differentiation of the ankles, as measured using Cross-Sample Entropy, during antiphase coordination at two movement frequencies, is associated with impaired coordination (high ankle coordination variability) and mobility limitations (Short Physical Performance Battery score ≤9). We conducted a cross-sectional study of community-dwelling older adults (N = 133) aged 80.04 (±4.67) years. In linear regression modeling, low ankle Cross-Sample Entropy (low motor control differentiation) was associated with poor (i.e., high) coordination variability at the slower (P = 0.026), but not the faster (P = 0.447), ankle movement frequency. In logistic regression modeling, low Cross-Sample Entropy at the slower (OR = 1.67; 95 % CI: 1.07-2.59) and faster (OR = 2.38; 95 % CI: 1.43-3.94) ankle movement frequencies were associated with increased odds for mobility limitations. Our findings support the hypothesis that ankle differentiation may be a motor control mechanism that links impaired coordination with mobility limitations.
Epilepsy, anti-seizure medication, intellectual disability and challenging behaviour - Everyone's business, no one's priority.
Seizure, 2020

People with Intellectual Disability (ID) and epilepsy are more likely to experience psychiatric conditions, challenging behaviour (CB), treatment resistance and adverse effects of anti-seizure medications (ASM) than those without. This population receives care from various professionals, depending on local care pathways. This study evaluates the training status, confidence, reported assessment and management practices of different professional groups involved in caring for people with ID, epilepsy and CB.
Neuronal signatures in cancer.
International journal of cancer, 2020

Despite advances in the treatment of solid tumors, the prognosis of patients with many cancers remains poor, particularly of those with primary and metastatic brain tumors. In the last years, "Cancer Neuroscience" emerged as novel field of research at the crossroads of oncology and classical neuroscience. In primary brain tumors, including glioblastoma (GB), communicating networks that render tumor cells resistant against cytotoxic therapies were identified. To build these networks, GB cells extend neurite-like protrusions called tumor microtubes (TMs). Synapses on TMs allow tumor cells to retrieve neuronal input that fosters growth. Single cell sequencing further revealed that primary brain tumors recapitulate many steps of neurodevelopment. Interestingly, neuronal characteristics, including the ability to extend neurite-like protrusions, neuronal gene expression signatures and interactions with neurons, have now been found not only in brain and neuroendocrine tumors but also in some cancers of epithelial origin. In this review, we will provide an overview about neurite-like protrusions as well as neurodevelopmental origins, hierarchies and gene expression signatures in cancer. We will also discuss how "Cancer Neuroscience" might provide a framework for the development of novel therapies.
Bottom-up perceptual salience and top-down retro-cues concurrently determine state in visual working memory.
Quarterly journal of experimental psychology (2006), 2021

Recent studies have demonstrated that in visual working memory (VWM), only items in an active state can guide attention. Further evidence has revealed that items with higher perceptual salience or items prioritised by a valid retro-cue in VWM tend to be in an active state. However, it is unclear which factor (perceptual salience or retro-cues) is more important for influencing the item state in VWM or whether the factors can act concurrently. Experiment 1 examined the role of perceptual salience by asking participants to hold two features with relatively different perceptual salience (colour vs. shape) in VWM while completing a visual search task. Guidance effects were found when either colour or both colour and shape in VWM matched one of the search distractors but not when shape matched. This demonstrated that the more salient feature in VWM can actively guide attention, while the less salient feature cannot. However, when shape in VWM was cued to be more relevant (prioritised) in Experiment 2, we found guidance effects in both colour-match and shape-match conditions. That is, both more salient but non-cued colour and less salient but cued shape could be active in VWM, such that attentional selection was affected by the matching colour or shape in the visual search task. This suggests that bottom-up perceptual salience and top-down retro-cues can jointly determine the active state in VWM.
The Flashed Face Distortion Effect Does Not Depend on Face-Specific Mechanisms.
Scientific reports, 2019

When normal faces are rapidly presented in the visual periphery, they are perceived as grotesque and distorted. This phenomenon, "The flashed-face distortion effect" (FFDE) is a powerful illusion that may reveal important properties of how faces are coded in peripheral vision. Despite the strength of the illusion (and its popularity), there has been almost no follow-up work to examine what governs the strength of the illusion or to develop a clear account of its phenomenology. Presently, our goal was to address this by manipulating aspects of facial appearance and spatial/temporal properties of the flashed-face stimulus to determine what factors modulate the illusion's strength. In three experiments, we investigated the extent to which local contrast (operationalized by the presence or absence of makeup), image eccentricity, image size, face inversion, and presentation rate of images within the sequence each contributed to the strength of the FFDE. We found that some of these factors (eccentricity and presentation rate) mattered a great deal, while others (makeup, face inversion and image size) made little contribution to the strength of the FFDE. We discuss the implications of these results for a mechanistic account of the FFDE, and suggest several avenues for future research based on this compelling visual illusion.
Unveiling the neuromechanical mechanisms underlying the synergistic interactions in human sensorimotor system.
Scientific reports, 2021

Motor synergies are neural organizations of a set of redundant motor effectors that interact with one another to compensate for each other's error and ensure the stabilization of a performance variable. Recent studies have demonstrated that central nervous system synergistically coordinates its numerous motor effectors through Bayesian multi-sensory integration. Deficiency in sensory synergy weakens the synergistic interaction between the motor effectors. Here, we scrutinize the neuromechanical mechanism underlying this phenomenon through spectral analysis and modeling. We validate our model-generated results using experimental data reported in the literature collected from participants performing a finger force production task with and without tactile feedback (manipulated through injection of anesthetic in fingers). Spectral analysis reveals that the error compensation feature of synergies occurs only at low frequencies. Modeling suggests that the neurophysiological structures involving short-latency back-coupling loops similar to the well-known Renshaw cells explain the deterioration of synergy due to sensory deprivation.
Use of complex visual stimuli allows controlled recruitment of cortical networks in infants.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2020

To characterize cortical networks activated by patterned visual stimuli in infants, and to evaluate their potential for assessment of visual processing and their associations with neurocognitive development.
An unusual finding of the pectoralis major muscle: decussation of sternal fibers across the midline.
Anatomy & cell biology, 2020

Variations of the pectoralis major muscle are commonly seen. However, during the routine dissection of an adult male cadaver, an apparently uncommon muscular variant was identified. In this cadaver, the sternal heads of the left and right pectoralis muscles crossed the midline and interdigitated with one another. In addition, the clavicular heads of both pectoralis major muscles were separated from the remaining parts of the muscles. Such anatomical variants such be kept in mind by clinicians and surgeons during patient evaluation and treatment.
Endovascular recanalization for symptomatic subacute and chronically occluded internal carotid artery: feasibility, safety, a modified radiographic classification system, and clinical outcomes.
Neuroradiology, 2020

To evaluate the feasibility and safety of endovascular recanalization for symptomatic subacute and chronic internal carotid artery occlusion (ICAO); to propose a newly modified radiographic classification of ICAO that can rigorously identify suitable candidates for endovascular ICAO treatment.
Risk factors for disease progression in patients with mild to moderate coronavirus disease 2019-a multi-centre observational study.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2020

Since December 2019, the novel coronavirus disease 2019 (COVID-19) that emerged in Wuhan city has spread rapidly around the world. The risk for poor outcome dramatically increases once a patient progresses to the severe or critical stage. The present study aims to investigate the risk factors for disease progression in individuals with mild to moderate COVID-19.
Transcranial Magnetic Stimulation and H
Neuroscience, 2021

This study aimed at better understanding the neurochemistry underlying transcranial magnetic stimulation (TMS) and magnetic resonance spectroscopy (MRS) measurements as it pertains to GABAergic activity following administration of allosteric GABA
Autophagy Induction Contributes to the Neuroprotective Impact of Intermittent Fasting on the Acutely Injured Spinal Cord.
Journal of neurotrauma, 2021

Spinal cord injury (SCI) is one of the leading causes of neurological disability and death. So far, there is no satisfactory treatment for SCI, because of its complex and ill-defined pathophysiology. Recently, autophagy has been implicated as protective in acute SCI rat models. Here, we investigated the therapeutic value of a dietary intervention, namely, intermittent fasting (IF), on neuronal survival after acute SCI in rats, and its underlying mechanism related to autophagy regulation. We found remarkable improvement in both behavioral performance and neuronal survival at the injured segment of the spinal cord of animals previously subjected to IF. Western blotting revealed a marked decrease in apoptosis-related markers such as cleaved caspase 3 levels and the bax/bcl-2 ratio in the IF group, which suggested an inhibition of the intrinsic apoptosis pathway. In addition, the expression of the autophagy markers LC3-II and beclin 1 was also increased in the IF group compared with
A Deep Dive to Illuminate V4 Neurons.
Trends in neurosciences, 2019

Neurons in the primate cortical area V4 have been recognized as being selective for intermediate-level visual features, including shape, texture, and color. But, there is no a priori reason why V4 neurons should respond to easily describable categories of visual stimuli. In a recent study Bashivan et al. (Science, 2019) used an artificial neural network to synthesize images that acted as 'super-stimuli' for recorded neurons in V4, pushing the boundaries of known neural responses in this brain region and raising broader questions about the potential for synergies between biological and artificial neural networks.