rudyvdbrink/CitationDatabase huggingface dataset:
Ask the Experts: Myofascial pain management: diagnosis, treatment options and challenges.
Pain management, 2012

Cesar Fernández-de-las-Peñas completed his Bachelor's degree in Physical Therapy in 2000, in Spain. He obtained his first PhD degree in Biomedical Sciences in 2007, under the supervision of Dr Lars Arendt-Nielsen at the Sensory-Motor Interaction Center at the University of Aalborg (Denmark). In 2008, he obtained his second PhD degree in Preventive Medicine, under the supervision of Drs Pareja and Cuadrado in Spain. He is the Head of the Division of the Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine at Universidad Rey Juan Carlos, Spain. He is also the group leader of the Pain Research Group at the same University. The research activities of his group are concentrated on neurosciences and assessment and management of pain. He has been invited as a Speaker to give lectures in more than 50 international and worldwide meetings with their related published abstracts/proceedings. He has published 170 publications in Journal Citation Reports' indexed journals, being the first author of approximately 100 in the top-ten journals of specialties such as Rehabilitation, Clinical Neurology, Pediatrics, Orthopedics, Sports Medicine or Anesthesiology. Most of his published articles concentrate on human pain research and the interaction between motor control and chronic pain. The most relevant topics of the articles are focused on neck pain, headache, carpal tunnel syndrome, lateral epicondylalgia, whiplash, breast cancer and neurophysiological effects of physical therapy. He has also published several chapters of textbooks and is the editor of five textbooks.
Comparison of Virtual Ultrasonographic Hysteroscopy with Conventional Hysteroscopy in the Workup of Patients Who Are Infertile.
Journal of minimally invasive gynecology, 2021

To compare the tolerability and diagnostic accuracy of virtual ultrasonographic hysteroscopy (VUH) with that of conventional diagnostic outpatient hysteroscopy in the workup of patients who are infertile.
Starting aripiprazole long-acting-once-a-month early in treatment: why, how and for whom? Expert consensus and practical recommendations by a panel of Italian clinicians.
Expert opinion on pharmacotherapy, 2016

Aripiprazole long acting once-monthly (AOM) is approved for the treatment of schizophrenia in adults. Despite recent evidence of AOM efficacy in the acute treatment of schizophrenia, it is recommended that AOM should be started once the acute symptoms are controlled and patients are stabilized. However, there currently are no definitive guidelines exactly describing when a patient is to be considered stabilized enough to start AOM and which the patients are for whom an early AOM start is to be preferred. Areas covered: A panel of Italian clinicians experienced with real world use of AOM met to discuss the scenarios where an early (i.e., immediately after controlling the acute symptoms) start of AOM may be suggested. Real life clinical experiences were shared and a consensus was reached. Expert opinion: There are cases when the risks/benefits ratio suggests to start AOM early, i.e. immediately after the acute symptoms have been stabilized, as opposed to starting it several days/weeks after the stabilization of acute symptoms. Clinical pearls, guidelines and opinions are provided.
A novel dual Ca2+ sensor system regulates Ca2+-dependent neurotransmitter release.
The Journal of cell biology, 2021

Ca2+-dependent neurotransmitter release requires synaptotagmins as Ca2+ sensors to trigger synaptic vesicle (SV) exocytosis via binding of their tandem C2 domains-C2A and C2B-to Ca2+. We have previously demonstrated that SNT-1, a mouse synaptotagmin-1 (Syt1) homologue, functions as the fast Ca2+ sensor in Caenorhabditis elegans. Here, we report a new Ca2+ sensor, SNT-3, which triggers delayed Ca2+-dependent neurotransmitter release. snt-1;snt-3 double mutants abolish evoked synaptic transmission, demonstrating that C. elegans NMJs use a dual Ca2+ sensor system. SNT-3 possesses canonical aspartate residues in both C2 domains, but lacks an N-terminal transmembrane (TM) domain. Biochemical evidence demonstrates that SNT-3 binds both Ca2+ and the plasma membrane. Functional analysis shows that SNT-3 is activated when SNT-1 function is impaired, triggering SV release that is loosely coupled to Ca2+ entry. Compared with SNT-1, which is tethered to SVs, SNT-3 is not associated with SV. Eliminating the SV tethering of SNT-1 by removing the TM domain or the whole N terminus rescues fast release kinetics, demonstrating that cytoplasmic SNT-1 is still functional and triggers fast neurotransmitter release, but also exhibits decreased evoked amplitude and release probability. These results suggest that the fast and slow properties of SV release are determined by the intrinsically different C2 domains in SNT-1 and SNT-3, rather than their N-termini-mediated membrane tethering. Our findings therefore reveal a novel dual Ca2+ sensor system in C. elegans and provide significant insights into Ca2+-regulated exocytosis.
Spontaneous intracranial hypotension with bilateral subdural hemorrhage: Is conservative management adequate?
Annals of Indian Academy of Neurology, 2013

The aim of this study is to report a case of spontaneous intracranial hypotension complicated by bilateral subdural hemorrhage that resolved with conservative management. A young male presented with severe orthostatic headache associated with dizziness, neck pain and diplopia. Brain imaging revealed characteristic pachymeningeal enhancement and bilateral subdural hemorrhage. Radionuclide cisternography confirmed the Cerebrospinal fluid leak at the cervical 5 and cervical 6 vertebral level. He had clinical and radiological resolution with bed rest, hydration and analgesics and has remained symptom free since then. Spontaneous intracranial hypotension may be complicated by bilateral subdural hemorrhage. A conservative treatment approach is a viable option, as it may help improve the clinical and radiological outcome, especially when interventional facilities are not available.
Mechanisms of Alcohol Addiction: Bridging Human and Animal Studies.
Alcohol and alcoholism (Oxford, Oxfordshire), 2020

The purpose of this brief narrative review is to address the complexities and benefits of extending animal alcohol addiction research to the human domain, emphasizing Allostasis and Incentive Sensitization, two models that inform many pre-clinical and clinical studies.
Examining population differences in cerebral morphometry between Chinese and Indian undergraduate students.
Neuroscience letters, 2017

The aim of this study is to examine potential population differences in brain morphometry using magnetic resonance imaging (MRI). Thirty-six Chinese and thirty-two Indian undergraduate students are included in this study. All images are processed using BrainLab toolbox to obtain the morphometric values of gray matter volume, cortical thickness, and cortical surface area in each region of interest (ROI). We use ROI-based analysis to investigate ethnic differences using the three types of measurements. Cerebral variations of the brain between Chinese and Indian groups are mostly distributed in the frontal lobe, temporal lobe, and occipital lobe. Subgroup analysis reveals sex differences between the two groups. Our study demonstrates population-related differences in brain morphometry (gray matter volume, cortical thickness, and cortical surface area) between Chinese and Indian undergraduates.
Reduced hippocampal and amygdala volume as a mechanism underlying stress sensitization to depression following childhood trauma.
Depression and anxiety, 2020

Stressful life events are more likely to trigger depression among individuals exposed to childhood adversity. However, the mechanisms underlying this stress sensitization remain largely unknown. Any such mechanism must be altered by childhood adversity and interact with recent stressful life events, magnifying their association with depression.
Parental mental health before and during pregnancy and offspring birth outcomes: A 20-year preconception cohort of maternal and paternal exposure.
EClinicalMedicine, 2020

Preterm birth (PTB) and small for gestational age (SGA) are increasingly prevalent, with major consequences for health and development into later life. There is emerging evidence that some risk processes begin before pregnancy. We report on associations between maternal and paternal common mental disorders (CMD) before and during pregnancy and offspring PTB and SGA.
Application of hybrid cranioendoscopic approaches in anterior skull base surgery.
Neurosurgical focus: Video, 2020

Anterior skull base approaches have included endoscopic or open microsurgical approaches for intracranial pathologies. However, discussion of a combined hybrid, cranioendoscopic approach, leveraging the benefits of both techniques, has been limited. Here we describe a case of a combined endoscopic, endonasal, and open microsurgical frontotemporal approach for resection of a complex anterior skull base lesion. A 62-year-old man with a large meningioma extending intradurally through the cribiform plate and sphenoethmoidal sinuses underwent a cranioendoscopic resection. Surgical techniques, including repair of the anterior skull base defect as well as complication avoidance and the coordination of multiple surgeons, are discussed. The video can be found here: https://youtu.be/Ti9tUUdWgJc.
Neuroimaging of valence decisions in children and adults.
Developmental cognitive neuroscience, 2021

To date, the neural underpinnings of affective components in language processing in children remain largely unknown. To fill this gap, the present study examined behavioural and neural correlates of children and adults performing the same auditory valence decision task with an event-related fMRI paradigm. Based on previous findings in adults, activations in anterior and posterior cingulate cortex, orbitofrontal cortex and left inferior frontal gyrus were expected for both positive and negative valence categories. Recent behavioural findings on valence decisions showed similar ratings and reaction time patterns in children and adults. This finding was successfully replicated in the present study. On a neural level, our analysis of affective language processing showed activations in regions associated with both semantic (superior and middle temporal and frontal) and affective (anterior and posterior cingulate, orbitofrontal and inferior frontal, insula and amygdala) processing. Neural activations in children and adults were systematically different in explicit affective word processing. In particular, adults showed a more distributed semantic network activation while children recruited additional subcortical structures.
Lithium and suicide prevention in mood disorders and in the general population: A systematic review.
Neuroscience and biobehavioral reviews, 2020

Suicide contributes to 1-4 % of deaths worldwide every year. We conducted a systematic review aimed at summarizing evidence on the use of lithium for the prevention of suicide risk both in mood disorders and in the general population. We followed the PRISMA methodology (keywords: "lithium", "suicide" AND "suicidal" on Pubmed, Cochrane CENTRAL, Clinicaltrial.gov, other databases). Inclusion criteria: lithium therapy in mood disorder or found in drinking water or scalp in the general population. Exclusion criteria: no lithium administration. From 918 screened references, 18 prospective (number of participants: 153786), 10 retrospective (number of participants: 61088) and 16 ecological studies (total sample: 2062) were included. Most of the observational studies reported a reduction in suicide in patients with mood disorders. All studies about lithium treatment's duration reported that long-term lithium give more benefits than short-term lithium in suicide risk The evidence seems to attribute an intrinsic anti-suicidal property of lithium, independent of its proven efficacy as a mood stabilizer.
Effects of transgenic expression of botulinum toxins in Drosophila.
Journal of neurogenetics, 2016

Clostridial neurotoxins (botulinum toxins and tetanus toxin) disrupt neurotransmitter release by cleaving neuronal SNARE proteins. We generated transgenic flies allowing for conditional expression of different botulinum toxins and evaluated their potential as tools for the analysis of synaptic and neuronal network function in Drosophila melanogaster by applying biochemical assays and behavioral analysis. On the biochemical level, cleavage assays in cultured Drosophila S2 cells were performed and the cleavage efficiency was assessed via western blot analysis. We found that each botulinum toxin cleaves its Drosophila SNARE substrate but with variable efficiency. To investigate the cleavage efficiency in vivo, we examined lethality, larval peristaltic movements and vision dependent motion behavior of adult Drosophila after tissue-specific conditional botulinum toxin expression. Our results show that botulinum toxin type B and botulinum toxin type C represent effective alternatives to established transgenic effectors, i.e. tetanus toxin, interfering with neuronal and non-neuronal cell function in Drosophila and constitute valuable tools for the analysis of synaptic and network function.
Anti-tau scFvs Targeted to the Cytoplasm or Secretory Pathway Variably Modify Pathology and Neurodegenerative Phenotypes.
Molecular therapy : the journal of the American Society of Gene Therapy, 2021

Immunotherapies designed to treat neurodegenerative tauopathies that primarily engage extracellular tau may have limited efficacy as tau is primarily intracellular. We generated tau-targeting single-chain variable fragments (scFvs) and intrabodies (iBs) from the phosphorylated tau-specific antibodies CP13 and PHF1 and the pan-tau antibody Tau5. Recombinant adeno-associated virus (rAAV) was utilized to express these antibody fragments in homozygous JNPL3 P301L tau mice. Two iBs (CP13i, PHF1i) and one scFv (PHF1s) abrogated tau pathology and delayed time to severe hindlimb paralysis. In a second tauopathy model (rTg4510), CP13i and PHF1i reduced tau pathology, but cognate scFvs did not. These data demonstrate that (1) disease-modifying efficacy does not require antibody effector functions, (2) the intracellular targeting of tau with phosphorylated tau-specific iBs is more effective than extracellular targeting with the scFvs, and (3) robust effects on tau pathology before neurodegeneration only resulted in modest disease modification as assessed by delay of severe motor phenotype.
Between Exploration, Pleasure, and Performance: Sexual Enhancement Medication Use among Older Gay and Heterosexual Men.
Journal of sex research, 2020

Pharmaceutical marketing campaigns and biomedical discourses tend to oppose two types of sexual enhancement medication (SEM) use. While "therapeutic" use is associated with older heterosexual men in committed relationships, "recreational" use is associated with young gay men, and with the context of casual sex. However, little is known about the real objectives of older men (especially older gay men) who use SEM or the contexts in which they use such drugs. Furthermore, SEM conveys representations of masculinity and sexuality that focus on performance and youth, and the influence of these representations on SEM users remains unexplored. Based on semi-structured interviews conducted, in French, in 2015-2016, with 27 Canadian men (12 heterosexual, 15 gay) aged 65 to 84 years, we examined the context in which older men used such medication and the reasons why they used it, and we explored how older men's notions of sexuality, masculinity, and aging influenced their experiences with SEM use. Our participants' narratives focused on three themes: exploring sexual possibilities/improving one's sex life, restoring sexual capacities, and masculinity and aging. This study improves our understanding of older men's use of SEM and contributes to the deconstruction of normative models of older men's masculinity and sexuality.
Distractor probabilities modulate flanker task performance.
Attention, perception & psychophysics, 2021

Expectations about upcoming events help humans to effectively filter out potential distractors and respond more efficiently to task-relevant inputs. While previous work has emphasized the role of expectations about task-relevant inputs, less is known about the role that expectations play in suppressing specific distractors. To address this question, we manipulated the probabilities of different flanker configurations in the Eriksen flanker task. Across four studies, we found robust evidence for sensitivity to the probability of flankers, with an approximately logarithmic relationship between the likelihood of a particular flanker configuration and the accuracy of subjects' responses. Subjects were also sensitive to length of runs of repeated targets, but minimally sensitive to length of runs of repeated flankers. Two studies used chevron stimuli, and two used letters (confirming that results generalize with greater dissimilarity between stimuli). Expanding the set of stimuli (thus reducing the dominance of any one exemplar) eliminated the effect. Our findings suggest that expectations about distractors form in response to statistical regularities at multiple timescales, and that their effects are strongest when stimuli are geometrically similar and subjects are able to respond to trials quickly. Unexpected distractors could disrupt performance, most likely via a form of attentional capture. This work demonstrates how expectations can influence attention in complex cognitive settings, and illuminates the multiple, nested factors that contribute.
Double Dissociation of Auditory Attention Span and Visual Attention in Long-Term Survivors of Childhood Cerebellar Tumor: A Deterministic Tractography Study of the Cerebellar-Frontal and the Superior Longitudinal Fasciculus Pathways.
Journal of the International Neuropsychological Society : JINS, 2020

Right cerebellar-left frontal (RC-LF) white matter integrity (WMI) has been associated with working memory. However, prior studies have employed measures of working memory that include processing speed and attention. We examined the relationships between the RC-LF WMI and processing speed, attention, and working memory to clarify the relationship of RC-LF WMI with a specific cognitive function. Right superior longitudinal fasciculus II (SLF II) WMI and visual attention were included as a negative control tract and task to demonstrate a double dissociation.
Hierarchical Representation of Multistep Tasks in Multiple-Demand and Default Mode Networks.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020

Task episodes consist of sequences of steps that are performed to achieve a goal. We used fMRI to examine neural representation of task identity, component items, and sequential position, focusing on two major cortical systems-the multiple-demand (MD) and default mode networks (DMN). Human participants (20 males, 22 females) learned six tasks each consisting of four steps. Inside the scanner, participants were cued which task to perform and then sequentially identified the target item of each step in the correct order. Univariate time course analyses indicated that intra-episode progress was tracked by a tonically increasing global response, plus an increasing phasic step response specific to MD regions. Inter-episode boundaries evoked a widespread response at episode onset, plus a marked offset response specific to DMN regions. Representational similarity analysis (RSA) was used to examine representation of task identity and component steps. Both networks represented the content and position of individual steps, however the DMN preferentially represented task identity while the MD network preferentially represented step-level information. Thus, although both MD and DMN networks are sensitive to step-level and episode-level information in the context of hierarchical task performance, they exhibit dissociable profiles in terms of both temporal dynamics and representational content. The results suggest collaboration of multiple brain regions in control of multistep behavior, with MD regions particularly involved in processing the detail of individual steps, and DMN adding representation of broad task context.
Analysis of Propagation of Slow Rhythmic Activity Induced in 
Brain connectivity, 2019

Slow wave oscillation is a synchronous oscillatory mechanism that is a characteristic wave type of the cerebral cortex during physiological deep sleep or anesthesia. It may play an important role in cortical analysis of sensory input. Our goal was (1) to develop optimal conditions for the induction of this slow rhythmic activity in adult rat cortical slices, (2) to identify connections through which the activity propagates between coupled cortical regions, and (3) to study the pattern of horizontal and vertical flow of activity developed spontaneously in cortical slices. Experiments were performed on intact or differently incised rat cortical slices. According to our results, spontaneous cortical activity develops reliably in slightly modified artificial cerebrospinal fluid, first in the entorhinal cortical region of horizontally cut slices and then it spreads directly to the perirhinal (PRh) cortex. The activity readily generated in layer 2/3 of the entorhinal cortex then quickly spreads vertically to upper layer 2-3 in the same area and to the neighboring regions, that is, to the PRh cortex. Synchronization of activity in neighboring cortical areas occurs through both callosal connections and layer 2-3 intrinsic network, which are important in the propagation of spontaneous, inherent cortical slow wave activity.
Fahr's disease: bilateral symmetrical striopallidodentate calcification in two brothers with two distinct presentations.
BMJ case reports, 2013

Bilateral striopallidodentate calcinosis, commonly known as Fahr's disease is a rare clinical entity present mainly with extrapyramidal signs and accompanied with metabolic, biochemical, neuroradiological and neuropsychiatric situations. It is characterised by the symmetrical and bilateral intracranial deposition of calcium associated with cell loss in the basal ganglia, cerebral cortex and cerebellum.In this study, we discussed two brothers' cases of Fahr's diseases who presented with different symptomatology. The first presented with walking difficulty, cramps and dysarthria and moderate memory impairment whereas the second with vertigo, ataxia, forgetfulness and headache. CT scans of both patients revealed intracranial diffuse bilateral calcifications in the basal ganglia and the cerebellum. The second patient revealed progressive cerebral atrophy but reduction in the calcification. Fahr's disease, although encountered rarely, should also be taken into account in the differential diagnosis of cases with abnormal intracranial calcifications along with other familial, congenital and metabolic diseases and syndromes.
MR-guided focused ultrasound application for moving target tumor ablation in abdominal area: coil selection.
Acta radiologica (Stockholm, Sweden : 1987), 2021

Magnetic Resonance Imaging (MRI)-guided Focused Ultrasound Surgery (MRgFUS) is a non-invasive thermal ablation method utilizing high-intensity focused ultrasound (HI-FU) energy for tissue ablation under MRI with real-time thermal mapping. Ablating to a dynamic target as in the liver is very challenging, requiring approval. A novel quality-assured liver tumor ablation system has been proposed for clinics. The paper reports the evaluation of conventional and new MR-receiving coils.