rudyvdbrink/CitationDatabase huggingface dataset:
Biomarkers of seizure severity derived from wearable devices.
Epilepsia, 2020

Besides triggering alarms, wearable seizure detection devices record a variety of biosignals that represent biomarkers of seizure severity. There is a need for automated seizure characterization, to identify high-risk seizures. Wearable devices can automatically identify seizure types with the highest associated morbidity and mortality (generalized tonic-clonic seizures), quantify their duration and frequency, and provide data on postictal position and immobility, autonomic changes derived from electrocardiography/heart rate variability, electrodermal activity, respiration, and oxygen saturation. In this review, we summarize how these biosignals reflect seizure severity, and how they can be monitored in the ambulatory outpatient setting using wearable devices. Multimodal recording of these biosignals will provide valuable information for individual risk assessment, as well as insights into the mechanisms and prevention of sudden unexpected death in epilepsy.
Mapping the principal gradient onto the corpus callosum.
NeuroImage, 2020

Gradients capture some of the variance of the resting-state functional magnetic resonance imaging (rsfMRI) signal. Amongst these, the principal gradient depicts a functional processing hierarchy that spans from sensory-motor cortices to regions of the default-mode network. While the cortex has been well characterised in terms of gradients little is known about its underlying white matter. For instance, comprehensive mapping of the principal gradient on the largest white matter tract, the corpus callosum, is still missing. Here, we mapped the principal gradient onto the midsection of the corpus callosum using the 7T human connectome project dataset. We further explored how quantitative measures and variability in callosal midsection connectivity relate to the principal gradient values. In so doing, we demonstrated that the extreme values of the principal gradient are located within the callosal genu and the posterior body, have lower connectivity variability but a larger spatial extent along the midsection of the corpus callosum than mid-range values. Our results shed light on the relationship between the brain's functional hierarchy and the corpus callosum. We further speculate about how these results may bridge the gap between functional hierarchy, brain asymmetries, and evolution.
Carpenter ants use diverse antennae sampling strategies to track odor trails.
The Journal of experimental biology, 2018

Directed and meaningful animal behavior depends on the ability to sense key features in the environment. Among the different environmental signals, olfactory cues are critically important for foraging, navigation and social communication in many species, including ants. Ants use their two antennae to explore the olfactory world, but how they do so remains largely unknown. In this study, we used high-resolution videography to characterize the antennae dynamics of carpenter ants (
Ambiguity in high definition: Gaze determines physical interpretation of ambiguous rotation even in the absence of a visual context.
Psychonomic bulletin & review, 2020

Physical interactions between objects, or between an object and the ground, are amongst the most biologically relevant for live beings. Prior knowledge of Newtonian physics may play a role in disambiguating an object's movement as well as foveation by increasing the spatial resolution of the visual input. Observers were shown a virtual 3D scene, representing an ambiguously rotating ball translating on the ground. The ball was perceived as rotating congruently with friction, but only when gaze was located at the point of contact. Inverting or even removing the visual context had little influence on congruent judgements compared with the effect of gaze. Counterintuitively, gaze at the point of contact determines the solution of perceptual ambiguity, but independently of visual context. We suggest this constitutes a frugal strategy, by which the brain infers dynamics locally when faced with a foveated input that is ambiguous.
Covert Subclinical Neurocognitive Sequelae During the Rehabilitation Course of Severe Coronavirus Disease 2019.
American journal of physical medicine & rehabilitation, 2021

Apart from respiratory symptoms, encephalopathy and a range of central nervous system complications have been described in coronavirus disease 2019. However, there is a lack of published literature on the rehabilitative course and functional outcomes of severe coronavirus disease 2019 with encephalopathy. In addition, the presence of subclinical neurocognitive sequelae during postacute rehabilitation has not been described and may be underrecognized by rehabilitation providers. We report the rehabilitative course of a middle-aged male patient with severe coronavirus disease 2019 who required intensive care and mechanical ventilation. During postacute inpatient rehabilitation for severe intensive care unit-related weakness, an abnormal cognitive screen prompted brain magnetic resonance imaging, which revealed destructive leukoencephalopathy. Subsequently, detailed psychometric evaluation revealed significant impairments in the domains of processing speed and executive function. After 40 days of intensive inpatient rehabilitation, he was discharged home with independent function. This report highlights the need for an increased awareness of covert subclinical neurocognitive sequelae, the role of comprehensive rehabilitation, and value of routine cognitive screening therein and describes the neurocognitive features in severe COVID-19.
Collaboration increases children's normative concern for fairness.
Journal of experimental child psychology, 2020

Collaboration increases equity in young children, but whether this precocious equity has a normative foundation or is primarily an interpersonal concern between collaborators remains an open question. Participants in this study were 3- to 7-year-old children (N = 104) from a rural community in Canada. In a novel third-party intervention game, children could intervene against inequitable sharing between third parties who earned resources collaboratively or individually. When resources were earned collaboratively, children intervened against inequity more often at an earlier age compared with when resources were earned individually. Children referenced equity or fairness to justify their decisions at a similar rate across the two resource acquisition contexts. These findings contribute to a growing body of evidence supporting the foundational role of collaboration in the development of fairness, providing novel evidence that this concern for fairness is indeed normative.
Decision Making through Integration of Sensory Evidence at Prolonged Timescales.
Current biology : CB, 2018

When multiple pieces of information bear on a decision, the best approach is to combine the evidence provided by each one. Evidence integration models formalize the computations underlying this process [1-3], explain human perceptual discrimination behavior [4-9], and correspond to neuronal responses elicited by discrimination tasks [10-14]. These findings suggest that evidence integration is key to understanding the neural basis of decision making [15-18]. But while evidence integration has most often been studied with simple tasks that limit deliberation to relatively brief periods, many natural decisions unfold over much longer durations. Neural network models imply acute limitations on the timescale of evidence integration [19-23], and it is currently unknown whether existing computational insights can generalize beyond rapid judgments. Here, we introduce a new psychophysical task and report model-based analyses of human behavior that demonstrate evidence integration at long timescales. Our task requires probabilistic inference using brief samples of visual evidence that are separated in time by long and unpredictable gaps. We show through several quantitative assays how decision making can approximate a normative integration process that extends over tens of seconds without accruing significant memory leak or noise. These results support the generalization of evidence integration models to a broader class of behaviors while posing new challenges for models of how these computations are implemented in biological networks.
Psychometric Properties of Two Implicit Associations Tests measuring Adult Attachment.
Psychologica Belgica, 2021

Adult attachment style has consequences for mental health, interpersonal functioning and emotion regulation. This occurs partly deliberately, also referred to as explicit, and partly on an automatic level outside of conscious awareness, also referred to as implicit. Whereas explicit adult attachment can be assessed with self-report instruments, measurement of implicit adult attachment requires indirect methods. This paper describes the psychometric properties of two Implicit Association Tests measuring general adult attachment in a population sample. The study evaluated the reliability and the validity of the Avoidant Attachment IAT (ANX-IAT) and the Anxious Attachment IAT (AVOID-IAT). Validity was evaluated against self-report measures of adult attachment style (RQ), psychopathology (SQ-48), and well-being (MHC-SF). The split-half reliabilities of both IATs were good; the test-retest reliability of the ANX-IAT was adequate; however the AVOID-IAT had low test-retest reliability. Both IATs did not explain variance in psychopathology additional to explicit measures. The AVOID-IAT showed added value over explicit measurement of avoidant attachment in explaining variance in well-being, particularly regarding emotional and psychological well-being. The ANX-IAT did not explain variance in any measure of well-being additional to the explicit measure of anxious attachment. Our findings provide a basis from which more valid IATs measuring general adult attachment can be developed. Furthermore, they suggest that implicit avoidant attachment might be related to well-being, particularly emotional and psychological well-being. However, further research is needed to investigate the role of implicit general adult attachment in mental health and to optimize the two IATs in terms of validity before clinical use is recommended.
[Treatment for central nervous system vasculitis].
Brain and nerve = Shinkei kenkyu no shinpo, 2015

Central nervous system (CNS) vasculitis is classified into two categories based on whether it is primary or secondary. Primary CNS vasculitis is rare disorder of unknown cause that is restricted to the brain and spinal cord. Currently, there are no randomized clinical trials for treatment of primary CNS vasculitis. Therefore, treatment regimens for primary CNS vasculitis have been derived from therapeutic strategies used in other kinds of vasculitis. Early detection is important because corticosteroid treatment with or without cyclophosphamide can often prevent serious outcomes and may result in a favorable response. However, because some patients are intolerant or respond poorly to combination therapy, development of novel treatment options is eagerly awaited. Several immunosuppressive agents such as mycophenolate mofetil, tumor necrosis factor-α blockers, and rituximab could be options for refractory patients.
Paroxysmal Movement Disorders: Recent Advances.
Current neurology and neuroscience reports, 2019

Recent advancements in next-generation sequencing (NGS) have enabled techniques such as whole exome sequencing (WES) and whole genome sequencing (WGS) to be used to study paroxysmal movement disorders (PMDs). This review summarizes how the recent genetic advances have altered our understanding of the pathophysiology and treatment of the PMDs. Recently described disease entities are also discussed.
Divided attention does not affect the acquisition and consolidation of transitional probabilities.
Scientific reports, 2020

Statistical learning facilitates the efficient processing and prediction of environmental events and contributes to the acquisition of automatic behaviors. Whereas a minimal level of attention seems to be required for learning to occur, it is still unclear how acquisition and consolidation of statistical knowledge are affected when attention is divided during learning. To test the effect of divided attention on statistical learning and consolidation, ninety-six healthy young adults performed the Alternating Serial Reaction Time task in which they incidentally acquired second-order transitional probabilities. Half of the participants completed the task with a concurrent secondary intentional sequence learning task that was applied to the same stimulus stream. The other half of the participants performed the task without any attention manipulation. Performance was retested after a 12-h post-learning offline period. Half of each group slept during the delay, while the other half had normal daily activity, enabling us to test the effect of delay activity (sleep vs. wake) on the consolidation of statistical knowledge. Divided attention had no effect on statistical learning: The acquisition of second-order transitional probabilities was comparable with and without the secondary task. Consolidation was neither affected by divided attention: Statistical knowledge was similarly retained over the 12-h delay, irrespective of the delay activity. Our findings can contribute to a better understanding of the role of attentional processes in and the robustness of visuomotor statistical learning and consolidation.
Radiographic evaluation of the tunnel position in single and double bundle anterior cruciate ligament reconstruction.
Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina, 2021

Aim To evaluate tunnel positioning on radiographs in singlebundle (SB) and double-bundle (DB) anterior cruciate ligament (ACL) reconstruction, to evaluate if measurement is accurate and reproducible. Methods Radiographs of 30 SB and 30 DB ACL reconstruction were reviewed by two examiners who measured tunnel positioning with the quadrant method on the femur (a=depth, b=height) and the Amis and Jakob method on the tibia. Intra- and inter-observer reliability were evaluated with intra-class correlation coefficient (ICC). Results A radiographic analysis was completed in all patients in a SB-group and in 27 in a DB-group (p>0.05). Intra-observer reliability was almost perfect on femoral (ICC: a=0.85, b=0.83) and tibial (ICC=0.87) side in the SB-group. In the DB-group, it was almost perfect for tibial anteromedial (AM) and posterolateral (PL) bundles (ICC: AM=0.84, PL=0.81) and for femoral PL bundle (ICC: a=0.83, b=0.82), and substantial for femoral AM bundle (ICC: a=0.78, b=0.74). Inter-observer reliability was almost perfect on tibial (ICC=0.81) and femoral (ICC: a=0.81, b=0.87) side in the SB-group, and substantial on tibial (ICC: AM=0.71, PL=0.77) and femoral (ICC: AM a=0.73, b=0.78; PL a=0.74, b=0.76) side in the DB-group. Standard deviation (SD) was low (±9%) with respect to the centre of tunnel(s). Conclusion The quadrant method and the Amis and Jakob method are accurate and reproducible measurement methods. Also, as SD was low, an outside-in approach with a front-entry guide, which is free-hand positioned, can be postulated as a reliable method to locate the femoral tunnel in SB reconstruction and the AM bundle in DB reconstruction.
Vascular PDGFR-alpha protects against BBB dysfunction after stroke in mice.
Angiogenesis, 2021

Blood-brain barrier (BBB) dysfunction underlies the pathogenesis of many neurological diseases. Platelet-derived growth factor receptor-alpha (PDGFRα) induces hemorrhagic transformation (HT) downstream of tissue plasminogen activator in thrombolytic therapy of acute stroke. Thus, PDGFs are attractive therapeutic targets for BBB dysfunction. In the present study, we examined the role of PDGF signaling in the process of tissue remodeling after middle cerebral arterial occlusion (MCAO) in mice. Firstly, we found that imatinib increased lesion size after permanent MCAO in wild-type mice. Moreover, imatinib-induced HT only when administrated in the subacute phase of MCAO, but not in the acute phase. Secondly, we generated genetically mutated mice (C-KO mice) that showed decreased expression of perivascular PDGFRα. Additionally, transient MCAO experiments were performed in these mice. We found that the ischemic lesion size was not affected; however, the recruitment of PDGFRα/type I collagen-expressing perivascular cells was significantly downregulated, and HT and IgG leakage was augmented only in the subacute phase of stroke in C-KO mice. In both experiments, we found that the expression of tight junction proteins and PDGFRβ-expressing pericyte coverage was not significantly affected in imatinib-treated mice and in C-KO mice. The specific implication of PDGFRα signaling was suggestive of protective effects against BBB dysfunction during the subacute phase of stroke. Vascular TGF-β1 expression was downregulated in both imatinib-treated and C-KO mice, along with sustained levels of MMP9. Therefore, PDGFRα effects may be mediated by TGF-β1 which exerts potent protective effects in the BBB.
Award for Distinguished Scientific Early Career Contributions to Psychology: Eliza Bliss-Moreau.
The American psychologist, 2018

The APA Awards for Distinguished Scientific Early Career Contributions to Psychology recognize psychologists who have demonstrated excellence early in their careers and have held a doctoral degree for no more than 9 years. One of the 2018 award winners is Eliza Bliss-Moreau, "for innovative contributions to the study of emotion in humans and animals." Her work in nonhuman primates spans behavioral neuroscience, psychophysiology, and evolutionary processes. Bliss-Moreau's award citation, biography, and a selected bibliography are presented here. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
Parsonage-Turner Syndrome: A Case of Idiopathic Upper Extremity Paresis Following Middle Cranial Fossa Resection of a Vestibular Schwannoma.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2016

In this patient report, Parsonage-Turner syndrome (acute brachial neuropathy) developed in our patient 1 day after resection of a vestibular schwannoma by a middle cranial fossa approach. Aiming to increase awareness of this rare disorder among neurotologists, we describe differential diagnoses, work-up, and management strategies.
White matter abnormalities across the lifespan of schizophrenia: a harmonized multi-site diffusion MRI study.
Molecular psychiatry, 2020

Several prominent theories of schizophrenia suggest that structural white matter pathologies may follow a developmental, maturational, and/or degenerative process. However, a lack of lifespan studies has precluded verification of these theories. Here, we analyze the largest sample of carefully harmonized diffusion MRI data to comprehensively characterize age-related white matter trajectories, as measured by fractional anisotropy (FA), across the course of schizophrenia. Our analysis comprises diffusion scans of 600 schizophrenia patients and 492 healthy controls at different illness stages and ages (14-65 years), which were gathered from 13 sites. We determined the pattern of age-related FA changes by cross-sectionally assessing the timing of the structural neuropathology associated with schizophrenia. Quadratic curves were used to model between-group FA differences across whole-brain white matter and fiber tracts at each age; fiber tracts were then clustered according to both the effect-sizes and pattern of lifespan white matter FA differences. In whole-brain white matter, FA was significantly lower across the lifespan (up to 7%; p < 0.0033) and reached peak maturation younger in patients (27 years) compared to controls (33 years). Additionally, three distinct patterns of neuropathology emerged when investigating white matter fiber tracts in patients: (1) developmental abnormalities in limbic fibers, (2) accelerated aging and abnormal maturation in long-range association fibers, (3) severe developmental abnormalities and accelerated aging in callosal fibers. Our findings strongly suggest that white matter in schizophrenia is affected across entire stages of the disease. Perhaps most strikingly, we show that white matter changes in schizophrenia involve dynamic interactions between neuropathological processes in a tract-specific manner.
Neural signature of reward-modulated unconscious inhibitory control.
International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 2016

Consciously initiated cognitive control is generally determined by motivational incentives (e.g., monetary reward). Recent studies have revealed that human cognitive control processes can nevertheless operate without awareness. However, whether monetary reward can impinge on unconscious cognitive control remains unclear. To clarify this issue, a task consisting of several runs was designed to combine a modified version of the reward-priming paradigm with an unconscious version of the Go/No-Go task. At the beginning of each run, participants were exposed to a high- or low-value coin, followed by the modified Go/No-Go task. Participants could earn the coin only if they responded correctly to each trial of the run. Event-related potential (ERP) results indicated that high-value rewards (vs. low-value rewards) induced a greater centro-parietal P3 component associated with conscious and unconscious inhibitory control. Moreover, the P3 amplitude correlated positively with the magnitude of reaction time slowing reflecting the intensity of activation of unconscious inhibitory control in the brain. These findings suggest that high-value reward may facilitate human higher-order inhibitory processes that are independent of conscious awareness, which provides insights into the brain processes that underpin motivational modulation of cognitive control.
Neurobıology of repressıon: a hypothetıcal interpretatıon.
Integrative psychological & behavioral science, 2012

Freud lived in a time when technology was incapable of explaining the biological correlates of the mental processes he described in psychoanalytic theory. During the last two decades, advances in neuroimaging methods and neuroscience have provided new insights for understanding mind-brain collaboration. Neurobiological underpinnings of psychoanalytical concepts have been an area of interest in recent years. This paper will suggest a new hypothesis for neurobiology of repression. This hypothesis will be discussed with the help of our knowledge about neurobiological mechanisms underlying perception of the emotional significance of an event, memory formation of an emotionally arousing stimulus, role of prefrontal cortex in modulation of subcortical information, neural mechanisms of suppression and molecular mechanisms of memory erasure. We suggest that dorsolateral prefrontal cortex, and especially its caudal part plays a major role for repression of childhood traumatic events. Possible molecular mechanism of memory erasure in repression is long term depression of glutamatergic neurotransmission between prefrontal cortex- thalamus- limbic system.