rubentito/OCR-IDL huggingface dataset:
fluorescent and autoradiographic meth- ods. 7. Investigate properties of nicotine bin- ding sites in specific brain areas through ex-house research. a. At Bowman Gray School of Medicine (Dr. S. A. Deadwyler). Dr. Robinson will collaborate. 1. Hippocampus Ongoing Initiate- 2. Hypothalamus 10/01/84 b. Microiontophoresis in awake animals Initiate- and brain-imaging (Dr. D. J. Wood- 01/01/85 ward, University of Texas Health Science Center at Dallas). 8. Add staff scientist (PhD cellular physiol- 01/01/86 ogist, endocrinologist or biochemist) and laboratory technician. 9. Implement nicotine titration methodology 12/31/87 involving single-cell electrode techniques in in-vitro cell cultures. 10. Establish new brain research techniques in-house. a. Electrophysiology of brain regions 12/31/87 (e.g., hippocampus, hypothalamus, other regions found to be of interest). b. Brain-slice imaging. 12/31/88 11. Detailed study of biochemical sequelae of 12/31/87 nicotine binding in cell culture and/or brain. 12. Extend work on cell-nicotine interactions to 12/31/87 include cell membrane biochemistry. 31 RW0154 4800 USX175 1232
PROJECT: Biobehavioral R&D WORK 7610 UNIT: Blood Chemistry BACKGROUND: The study of the blood chemistry of smokers is important because: 1) Smoke components such as nicotine have been reported to have physiological and psychological effects upon the smoker. The exact amounts of these materials in the bloodstream of the smoker at any given time must be known in order to understand how these effects come about. 2) The physiological and psychological effects are mediated through and other bodily substances such as hormones neurotransmitters. Therefore, the circulating levels of these substances must also be known. OBJECTIVES: Develop means to accurately assess the blood chemistry of smokers and use these to determine the effects of smoking on blood chemistry in humans. COMPLETION DATE STEPS: 1. Complete development of analytical method ASAP for nicotine and cotinine in blood. 2. Complete analysis of samples/data from 1983 ASAP study of smokers' blood. 3. Establish in-house RIA method for selected 07/01/84 compounds. 4. Develop HPLC techinque for selected cate- 12/31/84 cholamines in blood. 5. Conduct integrated study of smoking/stress 12/31/84 and blood chemistry. 6. Complete analysis of data from 5., above. 03/01/85 7. Service/support other projects/programs as Ongoing required. 8. Add staff scientist ( PhD/MS clinical chem- 01/01/86 ist). 9. Expand repertoire of assays to include COHb, 12/31/86 thiocy ante, blood gases, expired gases, others as needed. 1658 10. Build data base of information through a Ongoing series of studies (as described in 5 & 6, through 32 RW0154 4801 USX175 1233
above), improving methodology and integrat- 12/31/87 ing additional, more sophisticated measure- ment techniques, at 6-9 month intervals. 11. Develop quantitative information regard- Initiate by ing the processes of absorption, transport, 01/01/86 metabolism and excretion of smoke/tobacco components (with emphasis on nicotine) and their relation to useage behavior or other factors (e.g., demographics). 2588 33 RW0154 4802 USX175 1234
PROJECT: Biobehavioral R&D WORK Psychophysiology of 7610 UNIT: Smoking BACKGROUND: That tobacco products have effects on the psychophysiological states of consumers is well-established. For example, nearly every smoker will aver that smoking helps him/her to "relax". It has been found in some cases that smoking facilitates performance of boring but demanding tasks. Nearly all of the overt physiological effects of smoking (e.g., rise in heart rate and blood pressure) have been noted only in resting subjects; little is known about effects in active subjects. The psychological bases for these phenomena are not understood, yet to the consumer, some may be perceived as *benefits of smoking". OBJECTIVES: Develop knowledge and expertise in regard to the effects of tobacco use on the psychophysiological state of the consumer, including interactions with (for example) personality traits, emotions, stress, short-term activity level and life-style factors. STEPS: COMPLETION DATE 1. Complete pilot study, integrating meas- 12/31/84 urements of psychophysiological var- iables and blood chemistry, of smoking and stress. 2. Complete analysis of data from 1., above. 03/01/85 3. Complete analysis and interpretation of 1982 smoking/stress experiment. a. Statistical analysis. 12/31/84 b. Final report. 03/01/85 4. Complete development of technique for 04/01/85 measurement/analyi: of multichannel auditory and visual evoked potentials. 5. Complete pilot study of auditory and 07/01/85 visual evoked potentials. 6. Complete study of multichannel auditory 10/01/85 and visual evoked potentials. 7. Complete studies of effects of smoking on selected psychophysiological variables during active coping with stress. a. During game-playing stress. 07/01/85 656 b. Develop social interaction rating 34 RW0154 4803 USX175 1235
scale (Dr. C. D. Spielberger, U. South Fla. and Dr. Ray Rosenman, 07/01/85 SRI, consultants). C.C. During social interaction. 12/31/85 8. Develop techniques for analysis of effects 07/01/86 of smoking under "naturalistic" conditions. 9. Add staff scientist (MS/BS psychologist) 01/01/86 10. Build data base of information through a Ongoing series of studies (as described in 1 & 2 through above), improving methodology and integrat- 12/31/87 ing additional, more sophisticated measure- ment techniques, at 6-9 month intervals. 11. Expand Division capability in computerized Ongoing measurement technology. 12. Fund selected ex-house projects, for example; Initiate by long-term study of the interaction of smoking 01/01/86 and diet, longitudinal development of electro- encephalographic characteristics of smokers and non-smokers. 13. Continue support of research of Dr. H. J. Ey- Ongoing through senck. 12/31/87 35 RW0154 4804 USX175 1236
PROJECT: Biobehavioral R&D WORK Basic Sensory 7610, UNIT: Research BACKGROUND: At least three sensory modalities are involved in the perception of smoke by humans, namely; taste, smell and the common chemical sense. Each of these modalities is served by separate branches of the nervous system. Little is known about the relative importance of the sensations perceived by these separate senses to the satisfaction of the consumer. The relationships of smoking behavior and smoke chemistry to the sensory properties of smoke are also not well understood. OBJECTIVES: Develop understanding of the relative importance of sensory modalities to smokers and of the relationships among sensory and chemical properties of smoke and smoking behavior. STEPS: COMPLETION DATE 1, Acquire needed professional and support 10/01/84 staff. 2. Determine relative importance of sensory 12/31/85 modalities in at least one population of smokers. (Supports Consumer Satisfaction Interfunetional Program.) 3. Complete at least one major examination of 12/31/85 the relationships of sensory and chemical properties of smoke to detailed smoking behavior. 4. Determine effects of smoking on oral pH and 12/31/86 examine relationship of oral pH to sensory properties of smoke (in collaboration with Fundamental R&D). 5. Integrate sensory measures into psycho- Ongoing physiological studies, as appropriate. through 12/31/87 6. Provide liason/consultancy to other R&D Ongoing projects as required. 5658 36 RW0154 4805 http://legacy.library.ucsf.eda/tid/bkt36b00/pralfv.industrydocuments.ucsf.edu/docs/ffbb0035 USX175 1237
P.O. Box 14386 a EXT RESOR ED ;TANDA 3D U.S. POSTAGE Mariko Change PAID Itasca.IL Permit #F38 October #BYNKTBT #9999999999999999# Mr. Sample A. Sample 1234 Main Street Anytown, US 00000-0000 III SURGEON GENERAL'S WARNING: Smoking Philip Morris Inc. 1999 22789C3 By Pregnant Women May Result in Fetal Sponsored by Mariboro Full Flavor Kings Injury, Premature Birth, And Low Birth Weight. 16 mg "tar," 1.1 mg nicotine av. by ETC method Source: https://www.industrydocuments.ucstedu/docs/ffbb.g
Marlboro PULL OUT RACE GUIDE 500 WIN RACE TICKETS Here's your chance to join us for a thrill-packed weekend of racing. And bring along a friend. 3,750 winners will get 2 free tickets to the Mariboro 500 in Fontana, CA, including qualifying on Salurday, Marlboro 500 Oclober 30 and the race on Sunday, October 31, 1999. Here's how to Ticket Giveaway be one of them. Starting at 9:00 a.m. PT, Saturday, October 16, 1999, Official Rules. No purchase necessary. Open to residents of California who are smokers 21 years of age or older. call 1-800-99RACING (1-800-997-2246). Follow the directions given by the automated system. You'll be asked to enter the code number HERE'S HOW TO ENTER FOR YOUR CHANCE TO WIN TWO FREE TICKETS TO THE MARLBORO 500 in Fontana, California: above your name on the back of this mailing. The system will teli 1. Call our toll-free phone number, 1-800-99RACING (1-800-997-2248) you If you've won tickets and how to get them. follow the instructions. 2., lines will be open starting at 9:00- 1999, and will remain open until of 12:00 a.m. Pacific Time. October 17, 3, Only the first eligible 3,750 callers 1. Open only to residents of the state and are smokers, years of age or older at time pf,entry and have recelved this 5. Limit one completed call per telephone number climit one prize per person. 6. Odds of winning depend upon the time you the number of calls being made and whether or not prizes, ares at the time that you call. 7. Employees of Philip Morris (PM USA), its attiliates, sub- sidiaries, advertising and the immediate family members of each arefot USA ig not responsible tor incompiete phone calls, matfunctions or other phone system errors. All federal laws and regulations apply. All taxes are sole frespon mer No: 2 to the Martboro 500 in Fontana, CA on Saturday, and Sunday, October 31. Each prize has an approximate retail Winner's guest must be 21 years of age or oldet. Prize Is Winner must travel on dates specifled by PM USA. PM ISSA reserves the right to provide a prize of equal or greater value at its sole discretion; ng other substitution permitted. Tramsportation and accommada- tions not included. Acceptance of prize offered constitutes permission to use Sponsored by Marlboro winner's name/likeness for commercial purposes without further notice and mg "tar," 1.1 mg nicotine av. per cigater compensation, unless prohibited by law. 9. For the names of winners, avallable after November 5, 1999. send a self- addressed, stamped. #10 envelope to: Martboro 500 Wingers, P.O. Box 4706, Bialr, NE 68009-4706 SURGEON GENERAL'S WARNING: Smoking By Pregnant Women May Result in Feta Injury, Premature Birth, And Low Birth Weight. Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0036
2 anno EOVE SURGEON GENERAL'S WARNING: Smoking @ Phillp Morris Inc. 1999 22788C3 By Pregnant Women May Result in Fetal Sponsored by Mariboro Full Flavor Kings Injury, Premature Birth, And Low Birth Weight. 16 mg "tar," 1.1 mg nicotine av. per cigarette by FTC method SI asey aul dey auo you uo 110 aue] 01 J8AD BADW) Apjeuad JOJ sud paddois SI agey au por pue MOIS BOPH 10 persau JO LIBIS HSINH 01 Source: :https://www.industrydocuments.ucsf.edu/docs/ffbb0036
The Marlbero 500 is a show case for some of the world's best drivers. And it's a big challenge for CART racing's most successful feams. For Team Penske, it's a chance to run strong on a tough track, maintaining the effort that has made them CART's leader in race wins. the THE CARS Some things really are rocket science. Champ Cars like the Mercedes Penske are built out of carbon-fiber, with an aerodynamic package that uses a wing and underwing combination to keep the car locked down on track. Turbocharged V8 engines pump out 850 harsepower at over 14,000 r.p.m. FACE It's the last and fastest race of the season. This two-mile superspeedway is banked just enough to support high speeds, but still allow plenty of wheel-to-wheel action. The Mariboro 500 is a fitting finale for drivers who have only 250 laps to move up in the point slandings or win the championship. CHAMPIONSHIP POINTS 1st 20 7th 6 CART Championship points are awarded to 2nd 16 8th 5 each of the top 12 finishers, with one bonus 3rd 14 9th 4 point given to both the fastest qualifier and the 4th 12 10th 3 driver who leads the most laps in the race. 5th 10 11th 2 6th 8 12th 1 Sponsored by Mariboro Full Flavor Kings 16mg "tar," 1.1 mg nicotine av. per cigarette by FTC method. SURGEON GENERAL'S WARNING: Smoking By Pregnant Women May Result in Fetal Injury, Premature Birth, And Low Birth Weight. Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0036
LEGIS-TRAC DISTRIBUTION SOURCE Newsclip Battison Caperton Date 8/23/88 Becker Carter x Reported by Linda Buckley Curl Cannell Duhaime Woodson Yoe X Complete for each report: State/Locality Fenton, Missouri Bill/Ordinance #: Issue: Smoking Restriction Sponsor: Intro Date: Committee(s) Hearing Date(s): Summary : Action: Two of the municipality's aldermen are considering introducing an ordinance banning smoking inside city owned buildings. If passed the ordinance would not go into effect until January 1989. TI20450914 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0037
National Association of State Boards of Education 701 N. Fairfax St., Suite 340 Alexandria, VA 22314 (703) 684-4000 September 21, 1984 Mr. Peter Sparber The Tobaçco Institute 1875 Eye Street, N.W. Suite 800 Washington, D.C. 20007 Dear Peter: Here is the proposal as we discussed yesterday. It includes ideas that will enhance what The Tobacco Institute does well. Please review the proposal. We will be happy to provide additional information, as you see fit. We do, however, need some sense of budget levels. I look forward to hearing your comments later today. We are excited about the long-range possibilities for collaboration. Sincerely, Phyltis Phyllts L. Blaunstein Enclosure PLB:kgp Phillis L. Bhunstein TI52120750 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0038
PARLIAMENT MAILING - 1998 2072099877 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0039
Look what happened to the cigarette holder. PARLIAMENT It works like a cigarette holder works. 1005 Warning: The Surgeon General Has Determined That Cigarette Smoking Is Dangerous to Your Health. 1972 Kings:16mg "tar, 1.1mg nicotine-100's: 1.4mg nicotine av percigarette FTCReportAug.72 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0040
1988 PROFESSIONAL DATA K eeping up with computer salaries is an important part of our provide salary ranges. (In other words, the twentieth percentile repre- job-and something you must do to realize your full potential. sents the figure at which 20% of the respondents earn that figure or less. The median represents the figure at which half earn more and half In order to keep our Survey representative and unaffected by extremes, earn less. The eightieth percentile represents the figure at which 20% we have used median rather than mean figures. In addition, we have earn that figure or more.) included the twentieth upper and lower percentiles in each category to ($000) Reilar Medial 80% Commercial <2 19.9 24.3 28.7 Systems Analyst <4 24.0 29.3 35.2 2-3 23.5 28.0 32.5 4-6 28.4 33.0 38.9 4-6 25.8 30.4 35,0 > 6 32.7 38.0 45.2 > 6 30.6 36.0 42,5 Engineering/Scientific <2 23.4 30.0 34.2 Communications Analyst <4 27.6 32.5 37.4 -2-3 24.5 30.6 35.5 4-6 27.3 35.0 44.5 4-6 29.6 34.8 40.7 > 6 32.0 41.0 48.8 > 6 32.8 40.0 48.4 Data Base/Management <4 20.7 28.0 33.6 Microcomputer <2 18.0 22.0 27.1 Analyst 4-6 28.5 33.5 40.5 2-3 20.0 25.0 29.8 >6 34.9 41.5 49.4 4-6 26.1 33.0 38.9 Information Center <4 20.0 26.0 29.1 >6 34.8 43.0 51.6 Analyst 4-6 23,4 30.0 36,0 Minicomputer <2 19.3 23.2 28.8 >6 30.2 38.2 45.8 2-3 22.4 27.0 32.9 Office Automation <4 20.0 26.0 29.1 4-6 25.4 31.0 37.2 Analyst 4-6 25.7 33.0 39.6 > 6 30.3 37.0 45.9 > 6 30.5 38.6 46.3 Software Engineer <2 23.2 28.6 31.7 2-3 24.9 29.0 33,6 Hardware 30.4 44.0 63.4 4-6 29.1 35.0 40.6 Software 26.7 43.8 62.6 >i 6 33.6 41.5 50.2 Services 28.9 43.1 62.9 Systems Software <2 23.7 27.6 31.5 Technical Support <2 18.6 23.2 27.1 2-3 23,5 28.0 31.9 2-3 23.9 29.5 35.1 4-6 26.9 32.0 37.8 4-6 26.6 32.4 39,9 > 6 36.1 42.0 50.0 > 6 36.0 45.0 54.0 Management 45,5 61.5 85.5 Data Center Operations 33.2 40.0 52.0 Programming Development 39.8 48.0 58.1 Computer Operator <2 15.2 19.5 21.6 Software Development 44.0 53.0 64.1 2-3 16.0 20.0 22.8 Systems Development 44.8 54.0 65.3 4-6 23.3 28.8 34.3 Technical Services .42.5 50.0 61.5 >6 26.3 33.7 41.5 MIS Director 49.2 60.0 76.8 Edp Auditor <4 30.8 35.0 42.0 4-6 32.5 38.2 48.9 Consultant <4 25.4 31.0 37.2 > 6 34.0 40.0 48.4 4-6 30.1 35.0 41.3 Technical Writer or <4 17.2 21.0 24.8 > 6 38.7 45.0 53.6 Editor 4-6 27.3 32.5 40.0 Project Leader <4 25.8 31,5 37.8 >>6 31.2 39.5 47.8 4-6 30.1 35.0 41.3 6 36.1 50.0 source 42,0 édp° Recrurang TI57561716 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0041
,0. DA)- 5-28-93 JOB TICKET/ INVOICE # 3345 AReNA LGONCEPTS NAME PHONE# FAC 860- 2745 10201 N. Scottsdale Road, Suite 10 ADDRESS 860-2727 Scottsdale, Arizona 85253 (602) 991-2322 CITY STATE ZIP GRAPHICS PROOF DUE TUESD. DUE DATE ITEM JOBDESCRIPTION AMOUNT T/S 31/4" circle 5.00 PRINTING QUANTITY PMS NO. PMS NO. SIDE 1 SIDE 2 DESCRIPTION STOCK & COLOR MISC. INSTRUCTIONS AMOUNT 500 RED LABUS 74-25 BINDERY QUANTITY PAD CUT FOLD PERF. SCORE START NO. STAPLE DRILL COLL MISC. INSTRUCTIONS AMOUNT This Invoice Is due and payable upon completion of Job(s) which may be released only upon full payment (or balance owed If applicable). SUBTOTAL 79.25 Initialing this Invoice X declares your acceptance of TAX S31 job(s) ordered which releases Design Concepts of any liability to re- run, etc. 84.56 TOTAL DATE PAID 6-3-93 DEPOSIT 4000 CHECK # 1503 BALANCE DUE 44-56 infill TI45560726 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0042
cc: Media WW, CA Last page is 1995 The Tobacco Institute March 9, 1995 activity 1994-1995 ACTIVITY FOOD & DRUG ADMINISTRATION PROPOSALS TO REGULATE TOBACCO PRODUCTS February 25, 1994 FDA Commissioner Kessler writes to Coalition on Smoking OR Health, stating that he believes FDA has authority to regulate tobacco products and points to "manipulation of nicotine" as basis. However, he wants Congressional guidance before embarking on regulation. February 28 ABC-TV airs story alleging "nicotine spiking" on "Day One" program. March 3 Congressmen Synar (D-OK) and Durbin (D-IL) circulate "Dear Colleague" letter seeking cosponsors for H.R. 2147, to give FDA regulatory authority over tobacco products. Senate companion is S. 672, by Senator Bingaman (D-NM). March 4 ASH files petition to FDA for regulation of cigarettes. March 7 Coalition on Smoking OR Health submits new petition to FDA asking for classification of cigarettes as drugs. Day One airs second story on nicotine and ingredients. March 10 Congressman Waxman (D-CA) writes Attorney General Reno calling for Justice Department investigation of "the tobacco industry's failure to report the addition of nicotine to cigarettes as required by Federal law" on ingredients reporting. March 14 Kessler submits Freedom of Information request to Federal Trade Commission for data on nicotine values. Similar requests are made by Congressman Lancaster (D-NC) and Dr. John Slade, on behalf of the American Society of Addiction Medicine. Day One airs third story on nicotine. 1 TI40302226 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0043
March 16 In hearing on agriculture appropriations bill, Kessler and Subcommittee Chairman Durbin discuss potential for regulation of tobacco by FDA. HHS official states that department has asked for Justice Department investigation of cigarettes and nicotine; later, HHS issues clarification that such a request has been discussed with the DoJ, but not formally referred for action. Same day, Tobacco Institute holds briefing for 23 Members on nicotine issues. Coalition on Smoking OR Health also holds congressional briefing. March 24 Philip Morris files lawsuit against ABC-TV for libel on Day One. March 25 House Energy & Commerce Subcommittee on Health & the Environment, chaired by Waxman, holds oversight hearing on issues related to tobacco products and nicotine. Kessler and Tobacco Institute are among witnesses. April 7 President Clinton mentions FDA investigation of nicotine in response to question at Town Hall Meeting. April 8 National Public Radio airs story on cigarette ingredients. April 12 Six tobacco companies release list of ingredients added to tobacco in the manufacture of cigarettes. April 13 Waxman holds press conference to release material he alleges shows nicotine manipulation. April 14 Waxman subcommittee holds oversight hearing for chief executive officers of seven tobacco companies. Subcommittee requests documents from companies. April 19 Coalition on Smoking OR Health testifies before Durbin subcommittee urging regulation of tobacco products by FDA. April 28 Waxman subcommittee holds oversight hearing for two former Philip Morris scientists, Victor DeNoble and Paul Mele. 2 TI40302227 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0043
May 1 New York Times story reports that 91-percent of respondents to telephone survey believe cigarettes are addictive. May 2 New York Times story includes statement by Federal Trade Commission official that FTC is studying alternative tar and nicotine test methods. May 12 Coalition on Smoking OR Health filed statements from April 14 hearing with FDA in support of petitions for regulation of cigarettes. May 17 Waxman subcommittee hears Joseph Califano, representing Columbia University's Center on Addiction and Substance Abuse. May 23 Congressman Meehan (D-MA) and six other Members write Attorney General Reno requesting DoJ to "initiate a series of criminal investigations into tobacco company activities and statements." May 26 Waxman subcommittee hears James Glenn, president of Council for Tobacco Research. May 31 President Clinton mentions FDA's study of nicotine in remarks at swearing-in ceremony for Council on Physical Fitness. June 13 Coalition on Smoking OR Health writes all Members of Congress urging FDA regulation. June 15 House Rules Committee rejects Synar and Durbin request to be allowed to offer language from H.R. 2147 as amendment to agriculture appropriations bill. June 21 Waxman subcommittee hears Kessier on recent FDA activities regarding high-nicotine tobacco leaf, Y-1. Justice Department officials meet with Meehan to discuss request for investigation. June 22 Waxman subcommittee hears Thomas Sandefur, chief executive officer of Brown & Williamson. 3 TI40302228 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0043
June 24 Congressman Charlie Rose (D-NC) requests information from FDA regarding agency's consideration of potential regulation of tobacco products. June 30 Senator Ford writes Attorney General Reno regarding Meehan request. June Waxman writes National Cancer Institute asking for study of FTC test method for measuring tar and nicotine yields. July 19 FDA sends "partial response" to questions raised by Congressman Bilirakis (R-FL) at June 21 oversight hearing. July 20 Federal Trade Commission asks National Cancer Institute to convene consensus conference to study cigarette testing methodology and to recommend any changes. July 21 Republican members of Waxman subcommittee send two separate letters to FDA requesting information and documents as follow-up to June 21 hearing. July 27 Lancaster writes Kessler opposing FDA regulation of tobacco. August 2 FDA Drug Abuse Advisory Committee holds public hearing and considers staff questions on tobacco products and nicotine. Committee agrees that "Cigarettes and other forms of tobacco are addicting" and that "Nicotine is the drug in tobacco that causes addiction" but declines to recommend threshold level that causes addiction. August 5 Waxman subcommittee was to hold oversight hearing on tobacco sponsorship and advertising, but postpones hearing indefinitely. August 18 FDA sends additional documents to Bilirakis. August 19 Congressman Barlow (D-KY) writes Kessler opposing FDA regulation of tobacco. [Throughout the summer, additional Members write FDA on the issue.] 4 TI40302229 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0043
August 28 Jack Anderson column asserts that Kessler may have "October surprise" for tobacco industry. September 12 FTC's expert on tobacco advertising is detailed to FDA to work on tobacco issues. September 13 Institute of Medicine (an arm of the National Academy of Sciences) issues report including call for regulation of tobacco products to fight youth smoking. September 23 Congressman Lancaster and others write FDA requesting status of its investigation of tobacco. September 29 FTC announces proposed consent agreement with American Tobacco Company regarding advertising of Carlton cigarettes. FTC states "Consumers will not necessarily get less tar because the ratings published in the ads are obtained by smoking machines that do not reflect actual smoking, in part because they do not take into account such behavior as "compensatory smoking." October 3 Waxman writes Kessler urging response to Congressman Bliley's (R-VA) July 21 request for information "within the next two weeks." October 4 Coalition on Smoking OR Health announces nationwide petition drive by "Citizens to Protect Our Children From Tobacco" through early December. Will collect signatures calling on Congress, the Administration and FDA "to ensure that tobacco products are regulated (without banning them), including the way they are manufactured, sold, labeled, advertised and promoted; that the public's health is protected from the dangers of tobacco use to the greatest extent possible; and that children are not encouraged to smoke or given access to tobacco products." FDA official says that agency is continuing its "investigation into whether there is a basis for the agency asserting jurisdiction over nicotine-containing tobacco products." October 7 Republican members of Waxman subcommittee and selected members of full committee write Kessler expressing concern that FDA has been unresponsive to their July 21 requests for information. Rep. Boehner (R-OH) inserts statement in Congressional Record on "Tobacco Products and the Myth of Underregulation." 5 TI40302230 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0043
October 8 Congress recesses for elections. H.R. 2147 and S. 672 are effectively dead for the session. October 14 USA Today editorial calls for FDA regulation of tobacco products as well as ban on vending sales and $1 per pack tax increase. Response from Tobacco Growers Information Committee is printed. October 26 Wall Street Journal article asserts that U.S. Tobacco Co. manipulates nicotine levels in snuff. U.S. Tobacco issues statement refuting allegations. November 3-4 American Society of Addiction Medicine to hold conference on "nicotine dependence." November 10 FDA writes Congressman Lancaster stating that FDA continues to investigate "nicotine- containing tobacco" toward making a decision whether such products are subject to its jurisdiction. December 1 Congress adjourns. December 5-6 FDA Drug Abuse Advisory Committee meeting is postponed. December 5-6 At request of FTC, ad hoc committee of President's Cancer Panel holds consensus conference on tar and nicotine test method. Recommended changes include testing under various smoking parameters to result in range of potential yields; graphic representation of range of yields on packaging and advertising; listing of "other hazardous smoke constituents" on packaging and advertising. Report will go to FTC and to Congress in 1995. December 16 Nine Members of House, led by Congressman Bart Gordon (D-TN), write to White House Chief of Staff Leon Panetta urging Administration to ensure that FDA does not attempt to assert jurisdiction "over tobacco products marketed without therapeutic claims." December 19 Coalition on Smoking OR Health says that it has filed petition for RJR's new experimental cigarette, "Eclipse," to be regulated as drug. 6 TI40302231 Source: :ttps://www.industrydocuments.ucsf.edu/docs/ffbb0043
January 4, 1995 Congress convenes. January 10 Tobacco Institute presents polls showing public opposition to FDA regulation of tobacco. R.J. Reynolds Tobacco Company and allied organizations present petitions opposing additional regulation of tobacco. January 11 Coalition on Smoking OR Health presents petitions calling for FDA regulation. February 2-3 FDA Drug Abuse Advisory Committee is tentatively scheduled to meet, but no meeting is called. February 18 National Journal article, "Ganging Up on the FDA," states that FDA's study of whether it should regulate tobacco is still on track. February 25 Reps. Waxman and Stearns (R-FL) debate FDA regulation of tobacco on CNN's "Newsmaker Saturday" program. February 27 Reps. Coble (R-NC) and Clement (D-TN) circulate Dear Colleague letter refuting Coalition on Smoking OR Health letter's characterization of Tobacco Institute's polling on FDA regulation. March 8 Kessler delivers speech to Columbia Law School on youth smoking and "addiction" issues, noting that FDA's study continues. New York Times story states, "Officials say the agency will announce the results of its investigation sometime this summer. H April 6-7 FDA's Drug Abuse Advisory Committee is scheduled to meet. First day is closed session; no detailed agenda available. 7 TI40302232 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0043
deffers knowhnim Mihnessi Binned of 416 FDA 700d teater delmius proposal yas (meumer protect, and ken Tessler ans. protection mission T reform admin. anothing (hth+ safetz) xxxcam (others rufortance) / SI stage Feel Reg N.Y FOND vet. products QTA Q Jeffords . other aners Mont authority that we can help: A reduce admin. burden Export modifying statute to enable TI40302233 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0043
FDA regormy w/ technol. non RX duess Kennedy Reduce FDA's reg. bmilen the Q Coot-ben rule Et) imp ogder aprices riskratio benefit the consumer ? Regulatory burdon limitations to method thuse who impuse WSTS wenit always recing benefits Q So TI40302234 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0043
may FART tocs BEAR fin & in amplairs Access concerns the many a cellocation It priorities some his inc. inlussters S 1093 (1994) then then and meay >Than (1) otherogics source
ITSTHE LAW WE DO NOT SELL QUBACCO PRODUCTS GCU 846 The tobacco industry is committed to seeing this sign Working with national, state and local retail groups, the prominently displayed throughout the nation wherever tobacco industry's goal is to have this signage displayed cigarettes are sold. wherever cigarettes are sold. To learn more about "It's the Why? Very simply, we do not want our products in the Law," return the coupon today. We'll send you the material hands of young people. We never have. We never will. you need to get this program in your store. Using storefront, window and point-of-purchase displays, this sign will help you demonstrate that you observe The Tobacco Institute state laws prohibiting tobacco sales to minors. Lapel buttons P.O. Box 41169 and tips to help store employees verify age and deal with Washington, DC 20018 customers are also available for your use. PLEASE SEND ME MORE INFORMATION ON THE "IT'S THE LAW" PROGRAM Please Print NAME ADDRESS 1 TOBACCO INSTITUTE CITY P.O. Box 41169, Washington, DC 20018 STATE ZIP 10 Circle Reader Inquiry #244 TI43290647 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0046
CROSS REFERENCE FOLDER(S) TITLED: Ukky TOD + Health Research Projesson SEE: Cigarettes - Niotine Report March 1968. RE: "factors That defenience Nicotine Senel in Tobacco T10213-1616 Source:  ttp://industrydocuments.library.ucsf.edu/tobacco/docs/ffbb0047
THE TOBACCO AND HEALTH RESEARCH PROGRAM AT THE UNIVERSITY OF KENTUCKY Presented by Dr. Raymond C. Bard, University of Kentucky, at the Seventeenth Annual Convention of the Burley and Dark Leaf Tobacco Export Association, Inc., in French Lick, Indiana, on October 3. 1966. T10213-1617 Source: http://industrydocuments.library.ucsf.edu/tobacco/docs/ffbb0047
2 tions provide general guidance to the project directors in charge of specific research activities. Aside from the typical informal liaison so important among scientists, all project directors receive copies of the semlannual progress reports prepared by each project director. By these means, program participants are aware of what is going on in all projects making It easy for all concerned to be kept informed, to ex- change ideas, and generally to contribute to the overall endeavor. Fortunately, the three major physical facilities in which our program 1s housed are within easy walking distance of each other, so that physical separation of research activities is not a problem. Stated in general terms, the program is intended to develop tobacco plants with known genetic composition, grown under controlled environmental and nutritional conditions, which will then be treated under known circumstances In such ways as to yield cigarettes whose histories are relatively well understood. These cigarettes will be smoked mechanically, and the smoke and other combustion products analyzed in a varlety of ways for a number of components. Smoke pro- ducts will then be studied biologically to determine effects, if any, upon tissues and organs -- providing thereby the final link in our quest to evaluate the relationships between tobacco and health. Let me sketch for you, in broad outline, the individual major projects now underway in our program. Starting as we must with the tobacco plant, a team headed by Dr. G. W. Stokes (Departments of Agronomy and Plant Pathology) is determining the genetic control of the chemical constituents of the plant, over several successive generations, that might be related to smoking and health, including substances such as nitrogen bases, sterols, phenolic compounds, isoprenoids, etc. These plants are being grown in the field as well as in laboratory growth chambers, so that conditions are well controlled and subject to analysis. A blochemical group, under the direction of Dr. Andrew J. Hiatt (Department of Agronomy), is investigating the metabolic and regulatory processes of the tobacco plants reared by Dr. Stokes, from the green stage through post-harvest treatments, in order to determine what hap- pens to chemical constituents that may be related to smoking and health. Two groups, headed by Doctors John L. Ragland and John L. Sims (Department of Agronomy), are conducting investigations of experimental tobacco grown on extremes of soll types which differ with regard to nitrogen content, moisture, fertilizer use, and other environmental con- ditions, such as light and temperature. Tobacco grown under these de- fined conditions and cured in a variety of ways are being analyzed for chemical composition, to include such constituents as alkaloids, nitrates, amino acids, proteins, amines (especially nitrosamines), and other ni- trogenous substances whose concentrations in the plant may be affected .110213-1619
3 by nitrogen nutrition, including agricultural chemicals containing amines. Doctors Charles Yang and Malcolm R. Siegel (Department of Plant Pathology) are determining the changes in the chemical composition of tobacco leaf, including the formation of carcinogans, that occur during growth, curing, and storage of tobacco as a result of the metabolic activities of microorganisms, both the natural flora and the flora causing disease, to include viruses, bacteria, and fungi. Dr. Herbert F. Massey (Department of Agronomy) and his associates are developing methods for separating, identifying, and quantitatively determining in cigarette smoke, derived from the tobacco grown in the program, such constituents as polynuclear aromatic hydrocarbons and heterocyclic compounds. The objective of this project involving ana- lytical chemistry is largely the development of optimum methods, with the shortest performance time, to be used throughout our program. The efforts of Dr. Ellis V. Brown (Department of Chemistry) are dedicated to the isolation of heterocyclic bases in cigarette smoke and to the determination of their structures and quantities, placing emphasis on individual compounds not presently known to occur in cigarette smoke. In addition, he is launching a special study of the nitrosamines found in cigarette smoke condensates. He will employ such advanced methodology as required to attain his objective, including ultraviolet, infrared, fluorometric, and nuclear magnetic resonance spectrometry. Doctors John M. Patterson and Walter T. Smith, Jr. (Department of Chemistry) are conducting investigations on the pyrolysis of pure amino acids, (phenylalanine, tryptophan, leucine, lysine) alone and in com- bination, in a nitrogen atmosphere at certain temperatures in the range of 450-950C to obtain pyrolytic products which will then be isolated and identified by standard and advanced methods. Under the direction of Dr. Daniel L. Weiss (Department of Pathol- ogy), a team is Investigating the physiological activities of tobacco extracts and components, and of cigarette smoke condensates by deter- mining the biological responses of test animals. These responses will be studied in a variety of ways in order to establish evaluation cri- teria. Thus, the epithelial tissues of rodents will be employed as test sites, whereupon cytological analysis of these tissues will be performed utilizing suitable techniques, including electron microscopy. The objective of this project is the development of new and rapid bioassay procedures for cigarette smoke. Dr. Weiss and his associates are also studying the physiological effects of smoke and fractions thereof in the intact respiratory tract of rodents. An associated project involves the joint exposure of the respiratory tract of experimental animals to myxovirus infection (mouse adapted human Influenza virus strain) and tobacco smoke. T10213-1620 Source: http://industrydocuments.library.ucsf.edu/tobacco/docs/ffbb0047
; 4 Doctors Irene E. Roeckel and Louis D. Dubliler (Department of Pathology) are also investigating the respiratory epithellal tissue of mice, including tracheal, bronchial, and alveolar cells, in order to determine the effects of cigarette smoke and fractions thereof upon such tissue. Cell turnover rates and chromosomal patterns will be measured as a means of quantitating the effects of tobacco products up- on the tissues of the respiratory tree. Dr. Jerome E. Cohn (Department of Medicine) is determining the effect of tobacco products and fractions thereof on rat tracheal rings grown in tissue culture. The effects upon such epithellal structures as base, brush, and goblet cells are being studied histologically and histochemically, Dr. Rudolph J. Muelling (Department of Pathology) is conducting in- vestigations designed to determine the effect of trace metals in tobacco products on animal tissue utilizing, among other techniques, atomic absorption and X-ray analytical procedures. The objective of this project is the determination of Interrelationships between the trace metal con- tent of tobacco products and exposed tissue, especially as tissue changes occur. Under the direction of Doctors Paul Courant and Ernest Lalonde of the College of Dentistry, investigations are underway to determine the effect of tobacco, tobacco smoke, and fractions thereof on their ab- sorption by oral tissues, on the secretion of saliva, and on certain oral bacteria. Syrian hamsters are being employed for the absorption studies in which tissues will be examined histologically and cyto- chemically. Human subjects will be studied for the effect of smoking on salivary secretion, especially as this practice relates to salivary levels of thiocyanate and peroxidase. Doctors Paul Mandelstam and Douglas Rees (Department of Medicine) are studying the intestinal absorption of C14 or tritium labeled polynuclear aromatic hydrocarbon carcinogens in rodents, using this information for comparison of the similar absorption of tobacco prod- ucts. This project, like other biomedical projects, seeks to develop more meaningful tests to determine the biological effects of tobacco utilization. Dr. James Flesher (Department of Pharmacology), using radio- sotope technics, is measuring the distribution and metabolism of known carcinogens in the bodies of rodents, including the stomach, mammary gland, liver, fat, kidney, skin, and adrenal glands. This project will provide background for similar distribution studies using tobacco products. Finally, let me note the fact that the specially grown tobacco being studied in this program is processed under well-defined con- ditions and then manufactured into the cigarettes to be analyzed. A special manufacturing laboratory as well as a cigarette smoking T10213-1621 Source: : http://industrydocuments.library.ucsf.edu/tobacco/docs/ffbb0047
5 1 laboratory are being activated to provide materials to project directors who are analyzing tobacco by the chemical and biological ap- proaches described. You will noto that our program bagins with biology, and swings the full circle back to biology. This strategy is not surprising, for two major reasons. We are interested in learning abouc the effects of to- bacco, a plant whose composition is much affected by what happens to it while it is living and how it is treated thereafter, and we are in- terested in the effects of tobacco products, mainly smoke, upon the living consumer, namely, the human being. It is fortunate that our research is going on now, during what can be properly called the Age of Biology. Wichin the past two decades, there has been great progress in biological research, and a vast amount of new knowledge is being accumulated dealing with life at all levels, from the master molecules that control life and reproduction, through an Increasing insight into the biochemical mechanism: of cell behavior, toward the ultimate understanding of man as a complex living entity. Where and how the interaction between tobacco and man occurs is what we want to learn much more about, and this search deals, in the final sense, with biology. Summarizing these activities in terms of the number of individuals participating in the program thus far, let me tell you that 34 senior scientists and about twice that many assistants are involved at this time. Included in this program are four senior Agricultural Research Service scientists. Dr. Donald Burdick is engaged in smoke chemistry research, Dr. Paul Legg is pursuing genetics research, while Doctors Amber Chang and Robert Anderson are involved in several biochemical projects. As has been the tradition of collaborative research with ARS personnel, we welcome these individuals to our program, and we ex- press gratitude to them for their participation. This sketchy outline of our program will not satisfy the technical experts seeking details. 1 invite such experts to direct their in- quiries to our project directors or to me personally, and we shall be happy to provide details. For the proper implementation of our projects, the University has altered space for laboratories and animal quarters to accommodate project needs, representing a major capital investment on our part. Thus, we are underway. Progress will be slow as is true of any form of progress of lasting significance. I have been serving as the director of this program. It has been an exciting experience. We are still looking for an individual to fill this role, not only to coordinate the entire program internally, but to serve as the focus of information collection, from all sources, T10213-1622 Source:  http://industrydocuments.library.ucsf.edu/tobacco/docs/ffbb0047
6 regardless of location. In the latter capacity, with our scientists, we wish to maintain close Hiaison with centers for tobacco research throughout the world, in order to synthesize all data available into a meaningful pattern of understanding. Since we have more ideas for research than we can activate into specific projects, due to financial limitations, we seek public and private means to expand our program. We víew our current efforts as the core of "a much enlarged program, having as a dream the creation of a center for tobacco research, located in Lexington, unmatched any- where in the world for scope, capability, achievement, and coordination so that the total objective of the program will be attained. Let me point out that our current efforts will not approach the critical mass for quite a long time. I have borrowed the concept of the critical mass from the nuclear physicists who had to learn how much uranium or plutonium was needed to be put together in the same place at the same time before the desired chain reaction would occur, and which led finally to the atomic explosion. This analogy is per- tinent in the case being discussed. Until a large enough, coordinated effort is brought together, in the same place at the same time, the knowledge explosion needed will not occur. Splintered research efforts in many locations, as has been the situation in the past, will continue to lead to minor and ineffective sputterings, encouraging at times, but doomed to failure because the needed chain of facts and evidence will not be forthcoming. Half-vast plans for research will not yield the power of truth needed to guide the actions of responsible leadership, with the end result known to all of you. In closing, let me say that it is obvious that we are aware of the many difficulties facing us in this program. At times, we may seem naive, but such a posture is better than one exhibiting cynicism and depression from past defeats. We are enthusiastic, and we are vigorous. Only time will tell how successful we shall be. But we are aware that you and many others can assist us, and I solicit such aid, advice, and understanding from any quarter. We do not wish to work in isolation. We do wish to collaborate with any individual or group whose assistance and guidance will, in our judgment, facilitate our voyage toward the truth. While reading a report from the Texas A & M Research Foundation, I spotted a statement by Walter Lippmann which can be considered the motto of our program. Let me quote: "To bring to light the hidden facts, to set them into relation with each other, and to make them a picture of reality on which men can act.' I think these words describe our objectives well. Let me thank you again for the opportunity of talking with you. More important, let me thank you in advance for any help and under- standing you will extend to us. TI0213-1623 Source:  http://industrydocuments.library.ucsf.edu/tobacco/docs/ffbb0047
NILITARY YAS OBJECTIVES MAXIMIZE EXPOSURE OF MILITARY YAS TO THE CAMEL Brand. PROVIDE EFFECTIVE PRESENCE FOR SALEM AMONG BLACK MILITARY YAS. LEVERAGE THE VIABILITY OF CAMEL CREATIVE AMONG MILITARY YAS. PROVIDE ADVERTISING SUPPORT TO FIELD SALES/NARKETING EFFORTS. ! 0680 OVLOS Source:-http://industrydocuments.library.ucsf.edu/tobacco/docs/ffbb0048 -
MILITARY YAS OOH FORMS/RATIONALE OOH FORM RATIONALE ON-POST TELEPHONE Krosks PROVIDES SOLE MEANS OF COVERING MILITARY INSTALLATION. PAY PHONES USED PRIMARILY BY YOUNGER ADULTS. ANIMATED/NEON BULLETINS PROVIDE COVERAGE OF INSTALLATION EXITS/ENTRANCES. ANIMATION/NEON ENHANCES CANEL CREATIVE TO APPEAL TO YAS. 30-SHEETS PROVIDE COVERAGE OF MAJOR THOROUGHFARES LEADING IN/OUT OF MILITARY INSTALLATIONS. BULLETINS AVAILABLE IN ALMOST ALL MARKETS, PROVIDES COVERAGE OF SNALLER MARKETS WHERE LESS TRADITIONAL FORMS MAY BE UNAVAILABLE. Bus SHELTERS TARGET MILITARY YAS WHO USES MASS TRANSIT TO TRAVEL OFF-POST. TAXI TOPS CONTRACTED TO FOCUS ON GEOGRAPHIC AREAS KSBP's LIKELY TO BE FREQUENTED BY MILITARY YAS. 1680 Ot LOS i Source: ttp://industrydocuments.library.ucsf.edu/tobacco/docs/ffbb0048
MILITARY YAS OOH FORMS/RATIONALE 00H FORM RATIONALE STACKED 30-SHEETS BREAKS THROUGH CLUTTER, GENERATES ADDITIONAL IMPACT IN MARKETS WITH LIGHT INVENTORIES OF NONTRADITIONAL FORMS. 1-SHEETS PROVIDES HEAVY COVERAGE OF OFF-POST RETAIL OUTLETS, RECREATIONAL FACILITIES. BREAKS CLUTTER IN URBAN MARKETS. SUPPORTS IN-STORE PROMOTIONS. 8-SHEET BACKLIGHTS PROVIDE IMPACTFUL COVERAGE OF OFF-POST AREAS FREQUENTED BY MILITARY YAS. OFFERS LOCATIONS AT OR NEAR OFF-POST RECREATIONAL FACILITIES FREQUENTED BY MILITARY YAS. BACKLIGHTING ENHANCES APPEAL OF CAMEL CREATIVE. TECHNOMATION PROVIDES IMPACTFUL COVERAGE IN BARS, POOL HALLS, RETAIL OUTLETS AND OTHER YAS 50740 ESTABLISHMENTS. TECHNOLOGY ENHANCES CREATIVE'S APPEAL TO YAS. 2880 MALLS PROVIDE COVERAGE IN AREAS WITH LIMITED OOH. MOVING IMPRESSIONS (BACKCIT) PEOULE (SUECAGE AT PINPOINT LOCATIONS AND CONGREGATING AREAS. Source: http://industrydocuments.library.ucsf.edu/tobacco/docs/ffbb0048 1