rubentito/OCR-IDL huggingface dataset:
MEMORANDUM October 5, 1990 - Via Fax To: California Strategy Meeting Participants From: Kurt L. Malmgren Khm Please be advised that the strategy meeting will be held Tuesday, October 9, at 8:30 a.m. in the LaTrobe Room at the Westin Hotel, 24th and M Streets NW, Washington, D.C. Coffee and pastries will be available at 8:00 a.m. Luncheon will be provided since the meeting will go well into the afternoon. The agenda will be provided at the meeting. KLM:SC Linden Room Not LaTrobe Room Changed to Linden Room TI11411064 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0033
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1114L 91-0448 03 HB 699-FN STATE OF NEW HAMPSHIRE In the year of Our Lord one thousand nine hundred and ninety-one AN ACT relative to solid waste reduction. Be it Enacted by the Senate and House of Represen- tatives in General Court convened: 1 1 New Chapter; Solid Waste Reduction. Amend RSA by inserting after 2 chapter 149-N the following new chapter: 3 CHAPTER 149-0 4 SOLID WASTE REDUCTION 5 149-0:1 Statement of Policy. It is recognized that the state of New 6 Hampshire is depleting its space suitable for disposal of waste; that all 7 waste disposal sites pose a potential threat to the environment and water 8 supply; that improper use of existing disposal facilities is a threat to 9 public health, safety, and the environment; and that siting future disposal 10 locations is a critical issue in waste management planning. 11 149-0:2 Purpose. The state of New Hampshire hereby declares that the 12 state solid waste management policy shall be dedicated to decreasing the 13 threat to public health and the environment by minimizing the practice of 14 landfilling of solid waste through encouragement of voluntary recycling and 15 waste separation programs, by providing for greater enforcement of 16 restrictions on landfill dumping to ensure maximum safety in landfill 17 disposal practices, and by providing for bonding of landfill facilities to 18 provide ongoing protection from the dangers associated with landfill TI23921761 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0034
HB 699-FN - 2 - & practices. 2 149-0:3 Definitions. In this chapter: 3 I. "Beverage" means beer or other malt beverages and mineral waters, 4 soda water, and similar soft drinks in liquid form and intended for human 5 consumption, whether or not carbonated, including the following: alcoholic 6 beverages other than malt beverages; uncarbonated water; soups; fluid milk 7 products; natural, reconstituted, or frozen fruit, vegetable, or meat 8 juices; and liquids intended for medicinal purposes only. 9 II. "Beverage container" means the individual, separate, sealed 10 glass, metal, or plastic bottle, can, jar, or carton containing a beverage. 11 III. "Consumer" means every person who purchases a beverage in a 12 beverage container for use or consumption, or who returns a beverage 3 container to a recycling center. 14 IV. "Container" means the individual, separate, sealed, glass, 15 plastic, aluminum or nonaluminum metal, bottle, can, jar, or carton, which 16 shall include but not be limited to, the following: 17 (a) Containers that are identical or similar to beverage 18 containers, as defined in paragraph II. 19 (b) Food and drink containers made from high density plastic. 20 (c) All polystyrene (styrofoam) containers which shall include 21 but not be limited to: fast food packaging, coffee cups, and packaged soup 22 containers. 23 (d) All aseptic, or boxed juice, containers. 24 V. "Dealer" means every person in this state who engages in the sale 25 of containers to a consumer. TI23921762 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0034
HB 699-FN - 3 - 1 VI. "Department" means the department of environmental services. 2 VII. "Director" means the director of the division of waste 3 management. 4 VIII. "Distributor" means every person who engages in the bottling, 5 packaging or sale, or any combination thereof, of containers to a dealer in 6 this state, including any manufacturer who engages in such sales. 7 IX. "District" means a solid waste management district established 8 under 149-M:18. 9 x. "Division" means the division of waste management, department of 10 environmental services. 11 XI. "Facility" means that area or structure, including a landfill, 12 at which solid waste is collected or disposed of. 13 XII. "Manufacturer" means every person producing any type of 14 beverage containers for sale to distributors or dealers. 15 XIII. "Recycling center" means any facility which is established 16 pursuant to RSA 149-0:8. 17 XIV. "Separated waste" means solid waste which has been sorted or 18 collected apart from the general body of waste, and which would be 19 economically and commercially feasible to reuse in its present form or 20 would be economically and commercially feasible to process for use for 21 other purposes. 22 XV. "Source of waste" means the location at which the waste is 23 generated, collected, or transferred to a waste hauler for disposal in a 24 facility. 25 XVI. "Use or consumption" includes the exercise of any right or TI23921763 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0034
HB 699-FN - 4 - power over a container incident to the ownership of such container, other 2 than the sale or the keeping or retention of a container for the purposes 3 of sale. 4 149-0:4 Labeling Containers. Every beverage container sold or offered 5 for sale in this state shall clearly indicate in letters of not less than 6 1/4 inch type size by embossing or by a stamp or by a label or other method 7 securely affixed to the beverage container the following: 8 I. The refund value of $.05, as established by RSA 149-0:7, II. 9 II. Either the words "New Hampshire" or the abbreviation "N.H.". 10 149-0:5 Administration and Enforcement. The department of 11 environmental services shall administer and enforce this chapter through 12 the division of waste management. The division shall establish a landfill 3 reduction and recycling program to be financed by surcharges on disposal 14 fees at all solid waste disposal facilities. The director shall adopt 15 rules, under RSA 541-A, relative to: 16 I. Methods and procedures for inspection and testing of sources of 17 solid waste. 18 II. Standards and procedures for certification of the segregation 19 and recycling of a municipality's solid waste to qualify the municipality 20 for a reduction of the state surcharge imposed under RSA 149-0:6. 21 III. Procedures for the imposition of state surcharges on member and 22 non-member users of solid waste disposal facilities. 23 IV. Collection and recordkeeping of surcharges provided for under 24 this chapter. 25 V. Procedures for disbursements from the waste management fund and TI23921764 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0034
HB 699-FN - 5 - 1 the incentive fund. 2 VI. Procedures for application and review of municipal waiver 3 requests from the state surcharge imposed under RSA 149-0:6. 4 VII. Procedures for waivers established for municipalities and 5 private businesses. 6 VIII. Bonding requirements and rates. 7 IX. Emergency closing powers and other enforcement procedures, 8 including notice and hearing requirements. 9 X. Other rules necessary to administer this chapter. 10 149-0:6 State Surcharge for Disposal. 11 I. There is levied on containers which are sold to any retailer in 12 the state by a wholesaler a surcharge of $.07 per item. The surcharge 13 shall be paid by the wholesaler to the treasurer of the state to be 14 deposited in the waste management fund under RSA 149-0:11 or the incentive 15 fund under RSA 149-0:12. The surcharge shall be increased or decreased as 16 follows: 17 (a) When the recycling rate in the state is less than 40 percent 18 it shall be increased to $.10. 19 (b) If the recycling rate in the state is over 40 percent, then 20 the rate shall decrease $.01 for every 10 percent above the 40 percent. 21 II. Each wholesaler shall be permitted to add the amount of the 22 surcharge to the wholesale price of the item. 23 III. As of the effective date of this act each dealer shall be 24 permitted to add the surcharge to the retail price of the item. 25 IV. Each consumer shall be entitled to a refund of $.05 of the TI23921765 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0034
HB 699-FN - 5 - 1 the incentive fund. 2 VI. Procedures for application and review of municipal waiver 3 requests from the state surcharge imposed under RSA 149-0:6. 4 VII. Procedures for waivers established for municipalities and 5 private businesses. 6 VIII. Bonding requirements and rates. 7 IX. Emergency closing powers and other enforcement procedures, 8 including notice and hearing requirements. 9 x. Other rules necessary to administer this chapter. 10 149-0:6 State Surcharge for Disposal. 11 I. There is levied on containers which are sold to any retailer in 12 the state by a wholesaler a surcharge of $.07 per item. The surcharge 13 shall be paid by the wholesaler to the treasurer of the state to be 14 deposited in the waste management fund under RSA 149-0:11 or the incentive 15 fund under RSA 149-0:12. The surcharge shall be increased or decreased as 16 follows: 17 (a) When the recycling rate in the state is less than 40 percent 18 it shall be increased to $.10. 19 (b) If the recycling rate in the state is over 40 percent, then 20 the rate shall decrease $.01 for every 10 percent above the 40 percent. 21 II. Each wholesaler shall be permitted to add the amount of the 22 surcharge to the wholesale price of the item. 23 III. As of the effective date of this act each dealer shall be 24 permitted to add the surcharge to the retail price of the item. 25 IV. Each consumer shall be entitled to a refund of $.05 of the TI23921766 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0034
HB 699-FN - 6 - surcharge when any container is recycled at any approved recycling center. 2 V. Any solid waste district may establish and operate a recycling 3 center under RSA 149-0:8 which may be reimbursed from the incentive fund 4 established in RSA 149-0:12 and shall pay a $.05 refund to the consumer who 5 returns a container. 6 149-0:7 Inspections. The division is authorized to conduct inspection 7 and testing of waste disposal material at its source to determine the 8 extent of source separation and recycling or violation of waste disposal 9 rules for the purposes of the partial reduction of the state surcharge 10 under RSA 149-0:6. The department is authorized to assess the waste 11 generator the cost of such inspection. The division may conduct 12 reinspections as often as necessary, but at least once a year. 3 149-0:8 Recycling Centers. 14 I. Any municipality or a refuse disposal district established under 15 RSA 53-B may establish and operate a recycling center. In areas not served 16 by a municipal or district recycling center, the director may license any 17 person to establish and operate a recycling center. Each center shall 18 accept all containers, properly labeled under RSA 149-0:4 and approved as 19 eligible by the director, presented for refund by a consumer. 20 II. Each center shall pay to the consumer a refund of $.05 per 21 eligible container presented for refund. 22 III. All containers collected by a recycling center, for which the 23 $.05 has been paid to a consumer, shall become the property of the 24 recycling center. Each center shall, with the approval of the director, 25 contract for the recycling of containers collected by such center. TI23921767 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0034
HB 699-FN - 7 - 1 149-0:9 Exemptions from Surcharges. If materials to be recycled or 2 materials which have been segregated are moved to a solid waste disposal 3 center for more efficient handling, they shall be exempt from the 4 surcharges imposed under this chapter. However, if such segregated 5 materials or materials for recycling are subsequently disposed of in a 6 center in this state, the surcharges under this chapter shall apply. 7 149-0:10 Bond Required. 8 I. In order to assure that the burden of cleanup, protection of 9 aquifers, and protection of the public interest will not be left solely and 10 unfairly upon the town or city in which the center is located if a center 11 is closed or abandoned and problems occur, every operator or owner of a 12 center shall either provide a bond or demonstrate taxing authority to 13 secure the payment of costs of cleanup, should it become necessary within 14 50 years after closure or abandonment. 15 II. The bonds shall be issued by a surety company authorized to 16 engage in that business in the state. 17 III. The amount of the bond shall be based upon the total amount of 18 waste accumulated in the center, either in tons or cubic yards as 19 determined by the division, as of December 31 of each year as reported by 20 the operator or owner of the center. This amount shall be no less than the 21 initial volume of waste in the facility, plus that shown in the monthly 22 returns. 23 IV. The initial minimum bond shall be $10,000,000 regardless of 24 center size, except that a higher initial bonding amount shall be set by 25 the division upon determination that it is warranted by the size of the TI23921768 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0034
HB 699-FN - 8 - facility in tons or cubic yards. Under special situations as established 2 by rule, the division may authorize a lower amount after public hearing for 3 disposal sites operated by private business for their sole use for disposal 4 of wastes generated by that business. 5 V. Paid-up coverage under the bond shall extend for a period of 50 6 years after closure or abandonment of the solid waste disposal center. For 7 purposes of this chapter this shall be assumed to be 50 years from 8 January 1 of the year of closure or abandonment. 9 VI. A bond shall be extended by the owner or operator on January 1 10 of each year for an additional year so that the period covered into the 11 future is never less than 49 years. The amount of the bond shall be 12 increased each year to cover the additional quantity of waste disposed of ! in the center during the year. The total amount of the bond shall be 14 increased annually to cover larger expenditures for cleanup due to 15 inflation. For this purpose the annual inflation rate means the increase 16 in the consumer price index, issued by the United States Department of 17 Labor, Bureau of Labor Statistics, for the month of November. The division 18 shall advise the owners or operators of this figure no later than December 19 15 each year. 20 VII. Upon written request by an owner or operator, the division may 21 extend the January 1 date by 30 days, and a second extension may also be 22 granted. After 60 days a civil penalty of no more than $1,000 per day 23 multiplied by the tonnage of waste in the facility shall be assessed for 24 each day the bond is not extended. If after 180 days the bond still has 25 not been extended as required by this paragraph, the state shall close the TI23921769 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0034
HB 699-FN - 9 - 1 facility to further deposit of waste. The facility shall not be reopened 2 after such closure until after 3 public hearings and a finding by the 3 division that reopening is in the public interest. 4 VIII. Solid waste disposal districts established under RSA 147-M:18 5 shall not be required to furnish bonds if they can demonstrate in writing 6 to the satisfaction of the division that the participating towns and cities 7 are committed by contract with the district to payment of their share of 8 any cleanup costs occurring after closure or abandonment of the center. 9 IX. A state-wide bonding rate per ton or cubic yard shall be 10 established by the division by rule based on the average costs experienced 11 and projected for cleanup and public protection of currently closed waste 12 disposal sites within the state. This rate may be increased by the 13 division for any waste disposal facility in a location adjacent to an 14 aquifer or which because of the geology of the area may pose a future 15 threat or problem to the water supply. 16 149-0:11 Waste Management Fund. Ninety percent of the state surcharges 17 collected under RSA 149-0:6 shall be deposited into a waste management 18 fund, to be used exclusively for solid waste management. The division 19 shall administer the fund. Purposes for which the fund may be used 20 include, but are not limited to, conducting surveys and investigations of 21 solid waste centers or other locations where it is believed waste may have 22 been improperly disposed of, actions that may arise from such surveys and 23 investigations, testing wastes, demonstrating or testing new melhods or 24 procedures of waste handling or disposal, enforcement actions, purchase of 25 equipment and hiring of personnel related directly to waste management, TI23921770 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0034
HB 699-FN - 10 - assisting waste disposal districts and local community activities, and such 2 other activities with regard to waste disposal as may be required to 3 protect the public interest. 4 149-0:12 Incentive Fund Established. Ten percent of the state 5 surcharges collected under RSA 149-0:6 shall be set aside as a municipal 6 and waste disposal district incentive fund to be distributed as grants to 7 municipalities, whether inside or outside the state, and to New Hampshire 8 waste disposal districts. The division shall administer the fund. 9 Applications for grants shall be accepted by the division only from 10 municipalities and New Hampshire waste disposal districts and shall be 11 awarded on a competitive basis. A grant may be made for any proposal that 12 the division has reason to believe will reduce the solid waste flow in this 3 state. A grant may be for more than one year but there must be clear 14 measures of performance and accomplishment for second and subsequent years 15 and a provision for termination if these are not met. The incentive fund 16 shall cease to exist on December 31, 2000, and any moneys in the fund at 17 that time shall lapse to the general fund. 18 149-0:13 Grant Reports. On January 1, 1995, and annually thereafter, a 19 report on grants made by the division shall be presented to the speaker of 20 the house, the president of the senate, and to the governor. At a minimum, 21 the report shall list the grants made and the amount of each grant, 22 describe the grants' objectives, indicate what was achieved, and provide an 23 evaluation. 24 2 New Subparagraph; Waste Funds. Amend RSA 6:12, I by inserting after 25 subparagraph (mm) the following new subparagraph: TI23921771 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0034
HB 699-FN - 11 - 1 (nn) Moneys received under RSA 149-0:6, which shall be deposited 2 in the waste management fund and the incentive fund, as provided in 3 RSA 149-0:11 and 12, and moneys received under RSA 149-0:7, which shall be '4 returned to solid waste management districts in accordance with RSA 149-0:6. 5 3 Effective Date. This act shall take effect January 1, 1992. 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 TI23921772 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0034
HB 699-FN LBAO LSR 91-0448 2/8/91 FISCAL NOTE for an act relative to solid waste reduction. FISCAL IMPACT: The Department of Environmental Services indicates that this bill will increase state revenues by $39,500,000 in FY 1992 and $79,000,000 each fiscal year therafter. State expenditures will increase by $30,504 in FY 1992, by $62,882 in FY 1993, by $65,954 in FY 1994 and by $69,073 in FY 1995 for administrative costs. County and local expenditures will increase by an undeterminable amount. County and local revenues will increase by an undeterminable amount. In addition, this bill also deposits all revenues into restricted funds, the Waste Management Fund and the incentive fund, to be expended by the Department for the purposes contained in this act. METHODOLOGY: The Department states that approximately 1 million tons of solid waste are disposed in New Hampshire annually, and the state population of 1,000,000 uses 2 beverage containers per person each day or 2,000,000 annually. Revenues are calculated by multiplying waste produced times the assumed fees or [(1,000,000 x $6) + (2,000,000 x $.10)]. State administration expenditures are for (1) Waste Management Specialist IV, LG 23; (1) Attorney I, LG 23; (1) Accountant III, LG 20; associated benefits, office expense and first year office equipment costs. Counties and towns will pay more for solid waste disposal surcharge, but solid waste districts are entitled to reimbursement from the incentive fund. The disposal surcharge is assumed at $6 per ton, and the current surcharge fee of $.10 was applied to the calculation for the container surcharge. TI23921773 Source: https://www.industrydocuments.ucsf.edu/docs/ffbb0034
BIOCHEMICAL/BIOBEHAVIORAL R&D DEPARTMENT 771 BIOBEHAVIORAL RESEARCH DIVISION 1984-1987 BUDGET & ACTION PLAN datos DRAFT J.11. Reynolds U.S. Ex. 08/16/84 50,259 RW0154 4770 USX175 1202
TABLE OF CONTENTS PAGE SUBJECT 2 Table of Contents Planning Form 1. 1985-87 Action Program Summary 4 Planning Form 1A. Action Program Worksheet 5 Planning Form 2. 1985 Staffing Level Projections 6 Salaried Payroll Budget Worksheets 8 Planning Form 5. Departmental Expense Budget 12 Worksheet 13 Consulting Fees - 1984 14 Consulting Fees - 1985 Medical Research Programs - 1984 15 Medical Research Programs - 1985 16 Planning Form 6. Reconciliation, 1984 Operating 17 Plan to 1984 Current Estimate Planning Form 7. Explanation of Major Changes, 18 1984 Operating Plan to 1984 Current Estimate Planning Form 6A. Reconciliation, 1984 Current 20 Estimate to 1985 Operating Plan Planning Form 7A. Explanation of Major Changes, 21 1984 Current Estimate to 1985 Operating Plan Planning Form 6B. Reconciliation, 1985 Operating 24 Plan to 1986 Strategic Plan & 1986 Strategic Plan to 1987 Strategic Plan Planning Form 10. Company Member Ships 25 Planning Form 10A. Individual Memberships 26 Detailed Breakdown of Conference/Seminar Travel, 27 1958 1985 Plan 2 RW0154 4771 USX175 1203
Detailed Action Plans Smoke Component Dose 28 Nicotine Receptor Pharmacology 30 Blood Chemistry 32 Psychophysiology of Smoking 34 Basic Sensory Research 36 1538 3 RW0154 4772 USX175 1204
R.J.Reynolds Tobacco Company Planning Form 1 1985-1987 PLAN CORE ACTION PROGRAM SUMMARY Relates to Key Issue 275 epartment BIOCHEMICAL/BIOBEHAVIORAL R&D (771) Dept. No. 771 - Program: PROJECT: Biobehavioral R&D NO: 7610 The Biobehavioral Research Project is multidisciplinary and is designed to yield knowledge about the physiological, psychological, behavioral and sensory aspects of tobacco use, with emphasis on smoking. It includes work units dealing with detailed smoking behavior, the physiology and pharmacology of nicotine, the psychologital effects of smoking, and the basics of the sensory responses of smokers. Objective(s): Develop knowiedger about the physiological, psychoiogical, sensory and behavioral aspects of tobacco product use, for the following purposes; 1) aid in the design and development of new or improved products which address consumer wants, 2) define aspects of tobacco product use which are consciously or unconsciously perceived as benefits by users, 3) aid in addressing external Issues. Program Steps: Completion Dates 1. Smoke Component Dore 12-31-85 2. Nicotine Receptor Pharmacology 12-31-85 3, Blood Chemistry 12.31.85 4. Rychophysiology to research Smoking 12-31-85 5. Basic sensory 12-31-85 Current ( $ in Thousands} Impact Estimate Plan (Details on Planning Form 1A) 1984 1985 1986 1987 Headcount 10 10 15 16 611 751 1174 1302 Operating Expense (Use inflation-adjusied costs) Capital Expenditures 213 186 319 275 (Use inflation-adjusted costs) This Action Program was: Included in the 1984 Plan, but the timing and/or scope have changed as (Check if applicable) described on the reverse side. 1999 4 AURT Form 7204 - Rev. 7784 RW0154 4773 USX175 1205
PLANNING FORM 1A R.J.Reynolds Tobacco Company 1985-1987 PLAN ACTION PROGRAM WORKSHEET ($ in Thousands) Biochamics 1/Biobehorima! R&D Relates to Key Issue CORE, 215 Department: TIO behavioral Research Div Dept, No. 771 Current Estimate Plan 1984 1985 1986 1987 Headcount Incr/(Decr) - 1 4 / / 3 5 # 6 Other (Specify) Total 5 / Operating Expense Incr/(Decr) Variable Product Cost Leaf Casing Wrapping Labor (excl. Fringe) Other (Specify) - Sub-Total 3 General Operations Cost Utilities Maintenance Mfg. Support Auto & Truck Fleet Other (Specify) Sub-Total Administrative Cost (Specify) SALARY ERINGE 114 281 83 what OTHER OPERATING cost 26 142 45 Sub-Total 140 423 128 Total Operating Expense 140 423 123 5 RW0154 4774 http://legacy.library.ucsf.eda/tid/bkv36b00/puw.industrydocuments.ucsf.edu/docs/ffbb0035 USX175 1206
R.J.Reynolds Tow acco Company Form 7 Diu. of DEPARTMENT 77/ 1985 STAFFING LEVEL PROJECTIONS Current Proposed 1965 OPERATING PLAN CHANGES Auth'd. 12/31/84 Auth'd. 1st 2nd 3rd 4th to 12/31/84 12/31/84 Quarter Quarter Quarter Quarter 12/31/35 Monthly (No. 1) 6 6 6 6 6 6 Weekly (No. 3) 4 4 4 4 4 4 Waekly (No. 5) Hourly (No. 6) TOTAL - Regular Temporary Seasonal Summer Students 2 2. Other Staffing Level Change Justification All proposed staffing level changes must be justified in this section. Justifications should be concise but thorough enough to fully demonstrate need. Staffing level change justification is not required for non regular employees. DATE ADDITIONS/DELETIONS of CHANGE STATUS AND NUMBER OF JUSTIFICATION PAYBOLL PERSONS 05/20/85 Semmer 2 Suring the course feach year, backlogs of work, including date - reduction / data entry and profending accure let. It is extrement 4 helpful for services students to itlend to the reduction of this back log. J.1 add. him, eypo. water involving large reantion of ex-have Adjects Are prequently conversive truin is the interview The SUMMER states windurs are city hypef in working with sincerely of unit RECOMMENDED 11/13/2 s958 APPROVED 6 http://legacy.library.ucsf.edu/tid/bkv36b00/p&burce https://www.industrydocuments.ucsf.edu/docs/ffbb0035
Planning forms 3 and 4 are not applicable. 7 RW0154 4776 USX175 1208
The next four pages include the Salaried Payroll Budget Worksheets for 1984 and 1985. This first page includes a personnel key to identify individuals by their initials. Initials were used on the worksheets to save space. The 1985 salary increase schedule shows everyone who is expected to receive a performance rating of 2 budgeted for a 6% increase at 13 months from the last increase. This will put us well within the guidelines and leave room for maneuver when we have to produce our final salary increase schedule in December. Normally, additional guidelines are issued and we have a better fix on the pro- posed performance ratings by then, For example, there will usually be various gradations of "2" ratings, which will merit more or less of an increase. PERSONNEL KEY INITIALS NAME POSITION CLC C. L. CHAMBERLIN ASST. R&D CHEMIST RAD R. A. DAVIS SR. STAFF R&D PHARMACOL. DGG D. G. GILBERT SR. BEHAV. SCIENTIST PML P. M. LIPPIELLO SR. R&D CHEMIST JHR J. H. ROBINSON SR. BEHAV. SCIENTIST KGF K. G. FERNANDES LAB. TECHNICIAN SWI s. w. INGRAM LAB. TECHNICIAN PAG P. A. GRAY SUMMER STUDENT WRK. ('84) JCS J. C. STEPHENS SUMMER STUDENT WRK. ('84) SS1 Summer students SS2 requested for '85 1958 8 RW0154 4777 USX175 1209
REVISED SALARY PLAN - 1984 - #1 PAYROLL (081084 9:11 AM REV84) BIOBEHAVIORAL RESEARCH DIVISION NAME DATE PROJ. PAY RATE NO. PAY SUB- TOTAL FRINGE LAST PERIODS TOTAL INCR. DATE % INCR. T RATE CLC 80183 2,115 9 19,035 0 100184 5.67 M 2,235 3 6,705 25,740 8,752 RAD 40183 3,810 5 19,050 o 60184 5.51 M 4,020 7 28,140 47,190 16,045 DGG 90183 3,735 9 33,615 o 100184 6.69 M 3,985 3 11,955 45,570 15,494 PML 70183 3,300 5 16,500 0 60184 6.67 M 3,520 7 24,640 41,140 13,988 JHR 20183 3,385 1 3,385 o 20184 9.45 M 3,705 11 40,755 44,140 15,008 New 100184 4,000 o o 0 123184 0 M 4,000 3 12,000 12,000 4,080 TOTAL 215,780 73,365 GRAND TOTAL 289,145 9518 9 RW0154 4778 USX175 1210
REVISED SALARY PLAN - 1984 - 03 PAYROLL (081084 9:16 AM REV384) BIOBEHAVIORAL RESEARCH DIVISION PROJ. PAY RATE NO. PAY SUB- TOTAL FRINGE NAME DATE PERIODS TOTAL LAST INCR. DATE % INCR. T RATE 384 0 0 0 KGF 70984 123184 0 M 384 25.2 9,677 9,677 3,290 370 38 14,060 0 SWI 102583 5. 4 M 390 14.2 5,538 19,598 6,663 92484 0 427 0 0 New 100184 123184 0 M 427 13.2 5,636 5,636 1,916 0 0 480 0 Secy 100184 123184 0 M 480 13.2 6,336 6,336 2,154 177 12.4 2,195 2,195 220 PAG 52184 191 15 2,865 2,865 287 JCS 51784 46,307 14,530 TOTAL 60,837 GRAND TOTAL RW0154 4779 USX175 1211
PROJECTED SALARY PLAN - 1985 1081385 2:56 PM CONSALES) BIQBEHAVIORAL RESEARCH DIVISION / PROJECTED SALARY PLAN - 1985 - " PAYROLE (Includes new staff alreado requisitioned, bot not ngr.] (t NEAREST $5) HAILE PRDJ. ANH'ZD 1985 MIN. DAJE PROJ. PAY RATE NO. PAY SUB- TOTAL FRINGE PERF. RANGE COMPA- INCR. LAST PERIODS TOTAL RATING MIDPT. RATIO INTERVAL INCR. DATE : INCR, T RATE* CLC 1 30,056 0.89 12 100184 2,235 9 20,115 0 100185 6.0% M 2,370 3 7,110 27,225 8,168 RAD 2 56,808 0.85 13 68184 4,820 6 24,120 0 70185 6.0% n 4,260 6 25,560 49,688 14,904 DGG 2 52,000 0.92 13 100184 3,985 10 39,850 0 110185 6.07 M 4,225 2 8,450 48,300 14,490 PML 2 52,000 0.81 13 60184 3,528 6 21,120 0 70185 6.0% M 3,730 6 22,380 43,500 13,850 JHR 2. 52,000 0.86 13 20184 3,705 2 7,418 O 38195 6.0% If 3,925 10 39,250 46,668 13,998 New 2 56,800 0.85 13 100184 4,080 10 40,900 0 110185 6.0% n 4,240 2 8,480 48,480 14,544 TOTAL 41 263,845 79,154 TOTAL Stif It 342,999 - PROJECTED SALARY PLAN - 1985 - 13 PAYROLL (Includes sec'y. new technicion already requisitzoned and 2 sunner studenis) (I MEAREST 11) HAME PRGJ. ANN'ZO 1985 WIN. DATE PROJ. PAY RATE ND. PAY SUB- TOTAL FRINGE PERF RANGE COMPA- INCR. LAST PERIODS TOTAL RAUTNG MIDPT. RALIO INTERVAL INCR. DATE % INCR. I RATE KGF 2 24,960 0.80 13 70984 384 30.8 11,827 80585 6.0% a 407 21.2 8,628 20,455 6,137 SWI 2 24,960 0.81 13 92484 390 42.8 16,692 102885 6.0% 1 413 9.2 3,800 28,492 6,148 New 2 27,512 0.81 13 100184 427 43.8 18,703 110485 6.0% 11 453 8.2 3,715 22,418 6,725 Secy 2 1 0.80 ? 13 100184 488 43.8 21,029 110485 6.0% n 509 8.2 4,174 25,198 7,559 S51 190 15 2,850 2,850 285 552 190 15 2,858 2,850 285 TOTAL is 94,263 27,139 TOTAL SAF l3 121,402 GRAND TOTAL SALARY 358,108 ERAND TOTAL S&F 464,400 RW0154 4780 USX175 1212
This will take the place of Planning Form 5, since we do not have one for Department 771. OPERATING PLAN - WORKSHEET - BIOBEHAVIORAL R&D DIV. (081684 12:36 PM OP85) 1984 1984 84 PLAN 84 CURR CONTROL. CODE 1984 LATEST CURRENT TO 1985 EST TO EXP. PLAN EST EST CURR EST PLAN 85 PLAN SAL. #1 6001 255 245 216 (39) 264 48 SAL. #3 6003 26 25 46 20 94 48 FRINGE 6199 102 98 88 (14) 106 18 PROF FEES 9010 130 123 153 23 115 (38) BOOKS/PER 9031 1 1 2 1 REC/RELOC 9042 25 25 40 15 o (40) TRAVEL AIR 9069 7 14 5 (2) 13 8 TRAVEL BUS 9070 2 2 2 0 8 6 CONF TRAV 9081 12 5 7 ( (5) 7 0 CONF FEES 9082 5 5 1 ( 4) 1 0 CONV EXP 9083 5 5 70 65 DUES CORP 9091 1 1 1 0 1 0 DUES IND 9092 o 0 SERV TRNFS 9152 6 6 6 0 6 0 MFG TRANSF 9154 0 0 PHOT UNIT 2-9159 1 1 1 o 1 o ART UNIT 3-9159 0 o - AUD/VIS 7-9159 3 3 3 o 3 0 DATA PROC 9202 0 0 0 0 5 5 PRTG/PHOT 9206 0 o M/RPR M&E 9232 5 5 5 0 6 1 GEN SUPPL 9251 75 73 16 (59) 20 4 SUPPL CHEM 9257 10 10 12 2 15 3 NONCAP M&E 9555 0 10 10 TRAINING 9670 o 0 SUNDRY 9954 3 3 3 0 4 1 TOTALS 668 644 611 (57) 751 140 the RW0154 4781 USX175 1213
CONSULTING FEES - CLASS CODE 9010- BIOBEHAVIORAL RESEARCH OIV. 1984 (CONS4 12:46 PM 081684) f IRM REASON CONSEQUENCES OF AMOUNT OR PARTY OISAPPROVAL ($1008's spart tohe 129 1010 28 Dr. H. J. Eysenci Continue grast 1e support work 1h Valoable information effects of snoking DA nental infor resource lost, research nation processing in humans which RJR has previous- ly funded will not be extended Dr. S. A. Deaduyler Consult re nicotime pharnacelogy Hampers contimuation, 5 0 extension of research a}- ready begon Bellony- Recruit research pamelists Projects dependent en hu- 6 E 6 Carrigg, Inc. nan subjects cease Miscellaneous Consultation rt human and animal function Imporiant to 3 x 2, research gwidelines, eic. R&D respensibility 10 scientific and public arenas not net Integrated IDmies, Conduct research on effects ef Opporivaity to investi- 18 9 / Inc. sneking on oral chemistry gate oral pH & other phenomena imporiant to sensory perception lost Total 153 TIS to request 58 RW0154 4782 ittp://legacy.library.ucsf.eda/tid/bkv36b00/pw.industrydocuments.ucsf.edu/docs/ffbb0035 USX175 1214
CONSULTING FEES - ELASS CODE 9010- BIOBEHAVIORAL RESEARCH DIV. 1985 (CON35 12:02 PM 381684) FIRM REASOM CONSEQUENCES DE AMOUNT OR PARTY DISAPPROVAL (11000's) Dr. #. J. Eysenck Continue grant to support work in Ualuable information 60 907 chyte effects of sneking on nenial infor- resource lost, research malion processing 14 hunans which RJR has previous- 7144 ly Funded will not be extended Dr.S. A. Deadwoler Conselt re pharnacology Hampers contingation, 5 extension of research al- ready begun Betlony Recruit research pancissts Projects dependent on hu- 12 Carrigg, Inc. ndm subjects cease Consoltation Fl homen and animal Function inperiant to 3 research gordelites, etc. R$D respensibility to scientific and public arenas not net Integrated lonics, Coudect research en effects of Opportunity is investi- 25 lac. seeking on oral chemisiry gate oral pH & other - phenonene inportant to sensory perception lost Drs. C. Spielberger Develop and evaluate questionnaires, Important aspect of snok- 11 *R. Resennan or other psychological instruments ing and sirrss research fer study of interaction of snoking ignored or severely de- and Type-A personality traits layed Total 115 RW0154 4783 http://legacy.library.ucsf.ed8/id/bkv36p00/polfw.industrydocuments.ucsf.edu/docs/ffbb0035 USX175 1215
MEDICAL RESEARCH PROSRAMS - 1984 (MEDP84 081684 12:54 PM) (Charge cade 48-90-2001-9104-774) FIRM REASBN CONSEQUENCES BF AHOUNT OR PARTY DISAPPROVAL ($1000's) Bownan-Gray Electrophysiology of nicetine in Research into CNS et- 51 School of Medicine slice fects of ajcotine deleyed Bounan-Gray Electrophyslalogy of nicotine 18 Research into CNS ef- # 2 School of Medicine hypothelanic slice fects of nicotine delayed Total A , , 3 1 RW0154 4784 ittp://legacy.library.ucsf.ed8/tid/bkv36p00/pfw.industrydocuments.ucsf.edu/docs/ffbb0035 USX175 1216
MEDICAL RE SEARCH PROGRANS - 1985 (MEDP95 381684 12:54 PM) (Charge code 40-98-2001-9104-774) F IRM REASON CONSEQUENCES DF AMBUHT OR PARTY DISAPPROVAL ($1300's) Bownan-Gray Electrophpsiblogy of nicatione in Research into CHS ef- 47 School of Medicine hippocampal slice feets of nicotine delayed 5? is betterme. Bownan-Gray Electrophysiolegy of Dicotine in Resterch into CNS ef- School of Medicine hypethalemic slice fects of nicotine delayed Unisersify of Study influence of nicofine on brain Research nato CNS ef- 128 Texas Health Sci. function through special imaging and fects of nicotine delayed Center at Dallas application techmiques Total 212 RW0154 4785 USX175 1217
, intending U R.J.Reynolds Tc. JCCO Company 50283 8576 RECONCILIATION OF CHANGES IN CONTROLLABLE EXPENSES BY FUNCTION 1984 Operating Plan to 1984 Current Estimate Department (Birbaharina : Div.) ($ in Thousands) Dept. No. 771 Total Controllable MAJOR FUNCTIONS/ACTIVITIES (PF-2) (PF.5) $ $ $ Hdct. $ Amount $ Hdct. Amount $ Hdct. From 1984 Operating Plan Amount Rdct. Amount Hdct. Amount Hact. Amount Specific Programs/Act./Events 10 668 SACARY & FRINGE (33) PRUF. FEES 23 / REC & RECAC. 15 TRAVEL (11) CONVENTION EXP. 5 GEN. SUPPLIES (59) CHCM. SUPPLIE S 2 To 1984 Current Estimate 10 611 (See Instructions on Reverse Side)
R.J. Reynolds Tobacco Company Planning Form 7 EXPLANATION OF MAJOR CHANGES PI of 2 1984 OPERATING PLAN to 1984 CURRENT ESTIMATE Brochemel/Birbehavioral the Department (Birkehevirinal Div ) Dept. No. 771 Explain below the reasons for the specific programs/activities/events identified on PF-6. identify. where possible, the relationship to a specific Action Program, the objectives to be obtained and your estimate of the time frame for implementation, SALARYEFRINGE SPECIFIC PROGRAMS ACTIVITIES/EVENTS EXPLANATION $ (33) NEW SR. STAIT BUDSON Filting 01-01-E4 Now BUDGETE) FRom 10-01-84. NEW TECHNiCiAN & SECREASEY, ORIOINALLY UNBURGERED, Now BUDGETED FROM 10-01-84. PROFESSIONAL FEES SPECIFIC PROGRAMS EXPLANATION ACTIVITIES/EVENTS $ 23 ADDED GRAIL PH CONTRIB ADDED surpri For DF:H.J cysck Fos't of in kiew SPECIFICPROGRAMS EXPLANATION ACTIVITIES/EVENTS $ / LIBRARY RE QUESTED ADDITIONAL suffirit juits TO NEED in TEXTSTAERTNTS FOR EXPIRATE c Broke BASE. REC & REZOC. SPECIFIC PROGRAMS EXPLANATION ACTIVITIES/EVENTS $ 15 REvised ESTIMIATE PER INFORMATION SUPPLIEN with BUDGET (SEE > 5 OF Use additional pages if necessary. RW0154 4787 USX175 1219
R.J.Reynolds Tobacco Company Planning Form 7 EXPLANATION OF MAJOR CHANGES 1984 OPERATING PLAN to 1984 CURRENT ESTIMATE Department Dept. No. Explain below the reasons for the specific programs/activities/events identified on PF-6. Identify. where possible, the relationship to a specific Action Program, the objectives to be obtained and your estimate of the time frame for implementation TRAVEL SPECIFIC PROGRAMS ACTIVITIES/EVENTS (AILCODES) EXPLANATION (II) $ IMPROVED COST CANCELCATON OF CONVEN TioN ATTENDANCE PLANS TOLNEW RSTAFF the SOMIE EXISTING STAFF. CONVENTION SPECIFICPROGRAMS ACTIVITIES/EVENTS EXPENSE EXPLANATION $ 5 ADDED RESPONSIBILITY FORE sympbiler TRUNNING For RED CENTER DIDICATION GENERAL SPECIFIC PROGRAMS ACTIVITIES/EVENTS SUPPLIES EXPLANATION $ (59) 5% STAFF HE ADCOUNT Audion Historical CNT REALLOCATION TO MORE ACCURATE SPECIFIC PROGRAMS ACTIVITIES/EVENTS surplies EXPLANATION $ 2 IMPROVED HISTORICAL cost DITAT PEALLOCATION 76 irent ACCURITE (637 roos Use additional pages if necessary. 19 RW0154 4788 tp://legacy.library.ucsf.edw/tid/bkt36b00/pdfv.industrydocuments.ucsf.edu/docs/ffbb0035 USX175 1220
Planning Form 6A 50283 8579 R.J.Reynolds TOL .CCO Company RECONCILIATION OF CHANGES IN CONTROLLABLE EXPENSES BY FUNCTION 1984 Current Estimate to 1985. Operating Plan Bischavier ($ in Thousands) Department Dia.) Dept. No. 771 Total MAJOR FUNCTIONS/ACTIVITIES Controllable (PF.2) (PF-5) $ $ $ $ $ $ Hdct. Amount Hdct. Amount Hdet. Amount Hdet. Amount Hdct. Amount Hdct. Amount From 1984 Current Estimate Specific Programs/Act./Events 10 611 SALARY & FRINGE 114 PROF. FEES (38) / lec & RELOC. 140) TRAVEL 14 CONVENTION EXP. 65 curside Untra pics. 5 MIRPR mye I GEN. supplies 4 (Hen. surplies 3 NON-CAP HILE 10 SUNURY 1 To 1985 Operating Plan 10 751 (See Instructions on Reverse Side)
R.J.Reynolds Tobacco Company Planning Form 7A EXPLANATION OF MAJOR CHANGES PI of 3 1984 CURRENT ESTIMATE to 1985 OPERATING PLAN Biochemica 1/Bro Res Department (Biubehavicone Div.) Dept. No. 771 Explain below the reasons for the specific programns/ectivities/events identified on PF-6A, Identify, where possible, the relationship to a specific Action Program, the objectives to be obtained and your estimate of the time frame for implementation. SPECIFIC PROGRAMS SALARY & FRINGE ACTIVITIES/EVENTS EXPLANATION $ 114 SR. STAFF MEMBER BUDFERED For FIRL VERR 7ECHNICIAN SECRETHILY PHOGETES For ince YEAR. CPI & FRiNGE PROFESSIONAL SPECIFIC PROGRAMS FEES EXPLANATION ACTIVITIES/EVENTS $ (38) FEOULED SUNATA En: LR H.V.EXSENCA AUTHORIZE BRHL CHEMISTRY RESEARCH PSYCHOLOBICAL QUESTIONNAIRE DEVELOPMENT BOUKS/PERIODIALS SPECIFIC PROGRAMS EXPLANATION ACTIVITIES/EVENTS $ / support BASIC SENSORY PROGRAM REC & RELOC. SPECIFIC PROGRAMS EXPLANATION ACTIVITIES/EVENTS $ (40) NO NEW HEND OUNT TODE ADDERIN 1985 Use additional pages if necessary. 21 RW0154 4790 USX175 1222
R.J. Reynolds Tobacco Company Plonning Form 7A EXPLANATION OF MAJOR CHANGES p2 of 3 1984 CURRENT ESTIMATE to 1985 OPERATING PLAN Department Dept. No. Expisin below the reasons for the specific programs/activities/events identified on PF-6A, Identify, where possible, the relationship to a specific Action Program. the objectives to be obtained and your estimate of the time frame for implementation, TRAVEL SPECIFIC PROGRAMS ACTIVITIES/EVENTS ALL CODES) EXPLANATION 14 $ OF CINFERENCEISEHIINAR 7RHVEL For NEW & EXISTING 511 STAFF, WHICH UAS lionses IN 1984, CONVENTION SPECIFICPROGRAMS EXPENSE EXPLANATION ACTIVITIES/EVENTS 5 65 SYMPOSIUM TO ACCOUPANY R&D CENTER DEDICATION OUTSIDE DHTA SPECIFIC PROGRAMS ACTIVITIES/EVENTS PROCESSING EXPLANATION $ 5 STECIALTY DITRACTION & CODING of DATION funt i of INTER PERSONAL INTERACTIONS DURING Smining AND STRESS STUDIES, SPECIFIC PROGRAMS ACTIVITIES/EVENTS M E EXPLANATION 5 1 CONTINGENCY 70 COVER HOPED 1998 Use additional pages if necessary. 22 RW0154 4791 http://legacy.library.ucsf.ed8/tid/bkv36p00/polfw.industrydocuments.ucsf.edu/docs/ffbb0035 USX175 1223
R.J.Reynolds Tobacco Company Planning Form TA EXPLANATION OF MAJOR CHANGES P3 0/3 1984 CURRENT ESTIMATE to 1985 OPERATING PLAN Department Dept. No. Explain below the reasons for the specific programs/activities/events identified on PF-6A. Identify, where possible, the relationship to a specific Action Program, the objectives to be obtained and your estimate of the time frame for implementation, GENERAL SPECIFIC PROGRAMS ACTIVITIES/EVENTS SUPPLIES EXPLANATION $ 4 SUPPORT New RESEARCH HOTESA (BASIC Seusery) CHEMICAL SPECIFIC PROGRAMS ACTIVITIES/EVENTS SUPPLIES EXPLANATION $ 3 SUPPERT NEW RESIDENCING ARTA (BASIC sensors NON-CHP. SPECIFIC PROGRAMS M& E EXPLANATION ACTIVITIES/EVENTS $ 10 SUPPORT NEW RESEAREN AREA (BASIE SENSORY SUNDRY SPECIFIC PROGRAMS EXPLANATION ACTIVITIES/EVENTS / s support NEW RESERARCE AREA /BASIC SENSORY) ADDITIONAL COMPUTER 5ystem SURCHARE Use additional pages if necessary. 23 RW0154 4792 USX175 1224
50283 8583 R.J.Reynolds Tobacco Company Planning Form 68 RECONCILIATION OF CHANGES IN CONTROLLABLE EXPENSES 1985 Operating Plan to 1986 Strategic Plan 1986 Strategic Plan to 1987 Strategic Plan ($ in Thousands) KED Department (Brotehoviover U.) Dept. No. 771 From 1985 Operating Plan $ 757 From 1986 Strateqic Plan $ 1174 Increase/(Decrease} in: Increase/(Decrease) in: Salaries and Fringe 281 Salaries and Fringe 83 Action Programs 142 Action Programs 45 Specific Activities/Events Specific Activities/Events Other Other To 1986 Strategic Plan To 1987 Strategic Plan $ 1302 (See Instructions on Reverse Side) http://legacy.library.ucsf.edu/tid/bkv36b00/pafou e:https://www.industrydocuments.ucsf.edu/docs/ffbb0035
PLANNING FORM 10 - COMPANY MEMBERSHIPS (081484 3:56 PM PF 10) BIOCHEMICAL/BIOBEHAVIORAL RESEARCH (771) BIOBEHAVIORAL RESEARCH - J. H. Reynolds, Mgr. ORGANIZATION COMPANY ANNUAL REPRESENTATIVE DUES Association for Chemoreception Sciences J. H. Reynolds 1,000 25 RW0154 4794 USX175 1226
PLANNING FORM 10A - INDIVIDUAL MEMBERSHIPS (081484 3:53 PM PF10A) IIOCHEMICAL/BIOBEHAVIORAL RESEARCH (771) BIOBEHAVIORAL RESEARCH - J. H. Reynolds, Mgr. ANNUAL NAME ORGANIZATION : DUES R. A. Davis American Chemical Society 70 D. G. Gilbert American Psychological Association 75 P. M. Lippiello Sigma Xi 20 J. H. Reynolds American Association for Advancement of 55 Science J. H. Robinson American Association for Advancement of 55 Science New Staff American Psychological Association 75 350 26 RW0154 4795 USX175 1227
CONFERENCE/SEMINAR TRAVEL - 1985 PLAN (081684 9:53 PM SEM85) NAME CONFERENCE FEES AIR BUSINESS TRAVEL EXPENSE DGG American Psychological 100 400 700 Association Society for Psychophy - 100 400 700 DGG siological Research JHR FASEB, Anaheim, CA. 100 500 800 JHR Society for Neuroscience, 100 400 700 Dallas, TX. 10/20-25 International Society for 100 1,800 1,200 PML Neurochemistry, Riva del Gorda, Italy, 5/19-24 RAD Society for Neuroscience, 100 400 700 Dallas, TX. 10/20-25 RAD American Society for 100 400 700 Neurochemistry, Balti- more, MD. 3/3-8 ? 100 400 700 New Staff ? 100 400 700 Totals 900 5,100 6,900 12,900 Grand Total 25 RW0154 4796 USX175 1228
PROJECT: Biobehavioral R&D WORK Smoke Component 7610 UNIT: Dose BACKGROUND: To properly assess the sensory, physiological or psychological responses of smokers to products it is necessary to accurately determine the doses of smoke/tobaeco components to individuals. Since the dose to an individual is dependent on his/her smoking behavior (e. g., puff volume, frequency, duration, etc.), measurement and understanding of the effects of such behavior on smoke delivery is needed. OBJECTIVES: Develop or improve means to accurately determine the doses of nicotine and other smoke components to smokers. Determine the relationships of smoking behavior patterns to product properties (e. 8., sensory, physical, chemical). STEPS: COMPLETION DATE 1. Complete development of 2nd-generation ASAP human-mimic smoking machine (HMSM) . 2. Build additional or improved HMSM's Ongoing as required. 3. Improve methodology for measurement of Ongoing human puffing characteristies. 4. Execute study of human puffing character- istics in WINSTON and Marlboro smokers. a. Initiate study. ASAP b. Repeat tests as needed. Ongoing 5. Support programs in Basic Sensory Research, Blood Chemistry, and Psychophysiology a. Continue analysis of previously col- Ongoing lected data and collect new data as needed. b. Complete smoke regeneration experiments Ongoing as needed. 6. Service/support other projects/programs as Ongoing required. 7. Add capability to measure respiration. 01/01/65 8. Integrate respiratory measurements into Ongoing programs in Psychophysiology, Blood Chem- istry and Basic Sensory Research, as needed. 28 RW0154 4797 http://legacy.library.ucsf.ed8/tid/bkvB6p00/polfw.industrydocuments.ucsf.edu/docs/ffbb0035 USX175 1229
9. Add staff scientist (e.g., physical 01/01/86 chemist, engineer) to assume responsi- bility for overall progress of Work Unit. 29 RW0154 4798 http://legacy.library.ucsf.ed8/tid/bkv36p00/pu/w.industrydocuments.ucsf.edu/docs/ffbb0035 USX175 1230
PROJECT: Biobehavioral R&D WORK Nicotine Receptor 7610 UNIT: Pharmacology BACKGROUND : Current theories of the action of endogenous or exogenous agents on the central nervous system (CNS) postulate that observable psychophysiological effects are brought about in many cases by chemical interactions (binding) of the agents with specific areas (receptors) located in or on specific cell types with the CNS. Therefore, to fully understand exactly how agents produce their effects, it is necessary to locate and characterize receptors, identify the cell types or brain areas with which they are associated and determine what specific neurochemical processes or events occur as a result of interactions of receptors and active agents. OBJECTIVES: Establish ongoing, state-of-the-art research on nicotine receptor pharmacology, including ex-house as well as in-house programs. Develop and test hypotheses which relate the biochemistry of the nicotine/neuron interaction to observable psychophysiological effects. STEPS: COMPLETION DATE 1. Establish existence of nicotine binding Complete sites in undifferentiated neuronal cell cultures. 2. Determine effects of nicotine binding on Cyclic AMP selected biochemical processes (e.g., in C-1300, glucose uptake, cyclic AMP levels, neuro- 12/31/84. transmitter release, ion fluxes, etc.) Others on- in neuronal cell cultures. going. 3. Expand present data base of thermodynamics Ongoing of nicotine binding to neuronal cells to include new cell types, isolated cells in monolayer culture and brain homogenates. 4. Demonstrate pharmacological specifi- with cul- city of receptors in model neuronal tures, some cell cultures and in rat brain homo- done. With genates. brain, 12/31/85 5. Define kinetics of nicotine binding 07/01/85 to cells/cell membranes. 6. Identify and visualize cells and sites 07/01/86 which bind nicotine through immuno- 70 RW0154 4799 USX175 1231