rpgv/AptaCom huggingface dataset:
Aptamer: RIG-I (CL9) (ID# 7610)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGAGCGGAAGCGUGCUGGGCCACCAUCCGUAACUAGCUAAUACUUGUUAUCUUUUUAUUUUCAUAACCCAGAGGUCGAUGGAUCCCCCC
Target: RIG-I
Target chemistry: Protein
Affinity: 37.2 nM 
Reference: Hwang et al. "5'-Triphosphate-RNA-independent activation of RIG-1 via RNA aptamer with enhanced antiviral activity." Nucleic Acids Research 40(2011): 2724 - 2733Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: 2F11-14 (ID# 7946)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGACAAGAAUAAACGCUCAACGUUCAGUAUAACAGUCCGAGUCUAACACACAAUGGGACACUGAAUUCGACAGGAGGCUCACAACAGGC
Target: Ebola Virus VP35
Target chemistry: Protein
Affinity: 7.1 nM 
Reference: Binning, J., Wang, T., Luthra, P., et al. (2013) Development of RNA aptamers targeting Ebola Virus VP35. Biochemistry, 52(47):8406-8419. doi: 10.1021/bi400704dMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: SARS-CoV-1 3′-inverted Thymidine Aptamer NG8 (ID# 8029)
Aptamer chemistry: DNA
Aptamer sequence: CCGTAATACGACTCACTATAGGGGAGCTCGGTACCGAATTCATGTTGGTAGTTGGCTTGTGTTCGTGTGTTAAGCTTTCAGAGAGGATCCTT
Target: SARS-CoV-1 Helicase
Target chemistry: Protein
Affinity: 26.8 nM 
Reference: Shum, K. T., & Tanner, J. A. (2008). Differential Inhibitory Activities and Stabilisation of DNA Aptamers against the SARS Coronavirus Helicase. ChemBioChem, 9(18), 3037-3045. doi:10.1002/cbic.200800491Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: XMU3 (ID# 8092)
Aptamer chemistry: DNA
Aptamer sequence: TCCAGCACTCCACGCATAACCCCGTCCTCGGAAAGAGCGCGGGCCTGGGACGGCTACTGCCCGGATTTATGTGTTATGCGTGCGACGGTGAA
Target: epithelial cell adhesion  molecule (EpCAM)
Target chemistry: Cells
Affinity: 9.3 ± 1.3 nM 
Reference: Huang, M., Li, T., Xu, Y., Wei, X., Song, J., Lin, B., … Yang, C. J. (2020). Activation of Aptamers with Gain‐of‐Function by Small‐Molecule‐Clipping of Intramolecular Motifs. Angewandte Chemie International Edition. doi:10.1002/anie.202013570Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Dopamine (dopa2/c.1) (ID# 7506)
Aptamer chemistry: RNA
Aptamer sequence: GGGAAUUCCGCGUGUGCGCCGCGGAAGACGUUGGAAGGAUAGAUACCUACAACGGGGAAUAUAGAGGCCAGCACAUAGUGAGGCCCUCCUCCC
Target: Dopamine
Target chemistry: Small Organic
Affinity: 1.6 µM 
Reference: Mannironi, C., et al. "In Vitro Selection of Dopamine RNA Ligands." Biochemistry, 36 (1997):  9726-973.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Anti-EGFR (E07) (ID# 7710)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGCGCUCCGACCUUAGUCUCUGUGCCGCUAUAAUGCACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCGGAACCGUGUAGCACAGCAGA
Target: hEGFR and mEGFR
Target chemistry: Protein
Affinity: 2.4 nM 
Reference: N. Li et al. "Inhibition of Cell Proliferation by an Anti-EGFR Aptamer." PLoS One 6(2011): e20299.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Anti-EGFR (E03) (ID# 7723)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGCGCUCCGACCUUAGUCUCUGUGCUAGUAUAUCGCACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCGGAACCGUGUAGCACAGCAGA
Target: mEGFR and hEGFR
Target chemistry: Protein
Affinity: 29 nM 
Reference: N. Li et al. "Inhibition of Cell Proliferation by an Anti-EGFR Aptamer." PLoS One 6(2011): e20299.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Lup an 1 allergen, ??-Conglutin (#40) (ID# 7784)
Aptamer chemistry: DNA
Aptamer sequence: AGCTGACACAGCAGGTTGGTGGGGGTGGCTTCCAGTTGGGTTGACAATACGTAGGGACACGAAGTCCAACCACGAGTCGAGCAATCTCGAAAT
Target: ??-Conglutin
Target chemistry: Protein
Affinity: 360 nM 
Reference: P Nadal et al. DNA aptamers against the Lup an 1 food allergen. PLoS One 7(2012):e35253.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Botulinum neurotoxin type A (BoNT A) Aptamer (S132B-C22) (ID# 7888)
Aptamer chemistry: DNA
Aptamer sequence: GGGAGGAGGAGAGATGTGAACTTGACAGCGTGCCTAGAAGTCCAAGCTTAAATAACCACGCTCGACAAGCAGAAACTCTACACTGGACTGGCG
Target: BoNT A Light Chain
Target chemistry: Protein
Affinity: 87 nM 
Reference: Chang, T., Blank, M., Janardhanan, P., Singh, B., Mello, C., Blind, M., Cai, S. "In vitro selection of RNA aptamers that inhibit the activity of type A botulinum neurotoxin." Biochemical and Biophysical Research Communications 396(2010): 854-860.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HA12-16 (ID# 7904)
Aptamer chemistry: RNA
Aptamer sequence: GGGUUCACUGCAGACUUGACGAAGCUUGCUUGACGGAGAUCAAGGGCGAGUCUCAUACCAAGUUGUGGGGAAUGGAUCCACAUCUACGAAUUC
Target: gHA1 protein
Target chemistry: Protein
Affinity: "- nM (reported value)", 
Reference: Kwon H-M, Lee KH, Han BW, Han MR, Kim DH, et al. (2014) An RNA Aptamer That Specifically Binds to the Glycosylated Hemagglutinin of Avian Influenza Virus and Suppresses Viral Infection in Cells. PLoS ONE 9(5): e97574. doi:10.1371/journal.pone.0097574Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: 2mHNE-5 (ID# 8031)
Aptamer chemistry: DNA
Aptamer sequence: CCCUGUUCGCUAUCCCCCAUCCCCCGAUUGC
Target: HNE
Target chemistry: Protein
Affinity: 480 nM 
Reference: Liu, Zhixia, et al. "Evolved polymerases facilitate selection of fully 2'-OMe-modified aptamers" Royal Society of Chemistry, 8 (2017): 8179-8182Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Theophylline (AR6) (ID# 7598)
Aptamer chemistry: RNA
Aptamer sequence: GGAUAAUAGCCGUAGGUUGCGAAAGCGACCCUGAUGAGUCUGGAUACCAUGCAUGAUGCACCUUGGCAGUCUUACGAAACGGUAGCGAGAGCUC
Target: Theophylline
Target chemistry: Small Organic
Affinity: Not Mentioned in Database
Reference: Seetharaman et al. "Immobilized RNA switches for the analysis of complex chemical and biological mixture." Nature Biotechnology, 19(2001):336-341.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HA 12-16 (ID# 7893)
Aptamer chemistry: RNA
Aptamer sequence: GGGTTCACTGCAGACTTGACGAAGCTTGCTTGACGGAGATCAAGGGCGAGTCTCATACCAAGTTGATGGGGAATGGATCCACATCTACGAATTC
Target: HA protein (gHA1)
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Kwon, H. et al.  "An RNA Aptamer That Specifically Binds to the Glycosylated Hemagglutinin of Avian Influenza Virus and Suppresses Viral Infection in Cells."  PLOS One 2014, 9 1-9.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HA12-16 (ID# 7944)
Aptamer chemistry: RNA
Aptamer sequence: GGGUUCACUGCAGACUUGACGAAGCUUGCUUGACGGAGAUCAAGGGCGAGUCUCAUACCAAGUUGAUGGGGAAUGGAUCCACAUCUACGAAUUC
Target: Avian Influenza Glycoprotein Hemagglutinin (gHA1)
Target chemistry: Protein
Affinity: See Source (Non-Kd) nM 
Reference: Kwon H-M, Lee KH, Han BW, Han MR, Kim DH, et al. (2014) An RNA Aptamer That Specifically Binds to the Glycosylated Hemagglutinin of Avian Influenza Virus and Suppresses Viral Infection in Cells. PLoS ONE 9(5): e97574. doi:10.1371/journal.pone.0097574Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Zinc (ID# 7550)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGAGGAUACUACUGUCAUACGUUAGGCUGUAGGCGAGGUGAAAUGAGCGGUAAUAGCCUCAGCGUAGCAUAUGCAUGAAUUCGAAGCUUCGC
Target: Zinc
Target chemistry: Small Organic
Affinity: 1.2 mM 
Reference: Ciesiolka et al., "Selection of an RNA domain that binds Zn2+." Journal of RNA, 1(1995): 538-550.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Hen Egg White Lysozyme (cyt7-2) (ID# 7650)
Aptamer chemistry: RNA
Aptamer sequence: GGACCUCGGCGAAAGCUAACGUCUCAUGGCUAAAUUGCCAUGUUGCUACAAAUGAUAUGACUAGAGAGGUUAGGUGCCUCGUGAUGUCCAGUCGC
Target: Hen Egg White Lysozyme
Target chemistry: Protein
Affinity: 2.5 µM 
Reference: Robertson and Ellington. "In vitro selection of nucleoprotein enzymes." Nature Biotechnology, 19(2001): 650-655.    Hesselberth et al. "Simultaneous detection of diverse analytes with an aptazyme ligase array." Analytical Biochemistry, 312(2003): 106-112.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Phosphorylated ERK2 (ID# 7654)
Aptamer chemistry: RNA
Aptamer sequence: GGCGUGACCUGAUGAGUCACGCAGACGCUAGCGAAUUGGUUCCUCGAAAGGGGAAAGCGUUAUUAAGAAACCAAAAUGUGUUACGAAACGUUCCC
Target: Phosphorylated ERK2
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Vaish et al. "Monitoring post-translational modifications of proteins with allosteric ribozymes." Nature Biotechnology, 20(2002): 810-815.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: GBN2 (ID# 8110)
Aptamer chemistry: DNA
Aptamer sequence: GACGCTTACTCAGGTGTGACTCGCTCCACTGGTCCGGATCACTTGATATGTCGTGCGGCAGTCGTTTACATCCCGAAGGACGCAGATGAAGTCTC
Target: Nervous necrosis virus (NNV)
Target chemistry: Other
Affinity: 27.96 nM 
Reference: Zhou L, Wang S, Yu Q, et al. Characterization of Novel Aptamers Specifically Directed to Red-Spotted Grouper Nervous Necrosis Virus (RGNNV)-Infected Cells for Mediating Targeted siRNA Delivery. Front Microbiol. 2020;11:660. Published 2020 Apr 30. doi:10.3389/fmicb.2020.00660Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Ethanolamine (14.3) (ID# 7456)
Aptamer chemistry: DNA
Aptamer sequence: ATACCAGCTTATTCAATTTGAGGCGGGTGGGTGGGTTGAATATGCTGATTACCCCATCGGAGAACGTTAAGGCGCTTCAGATAGTAAGTGCAATCT
Target: Ethanolamine
Target chemistry: Small Organic
Affinity: 6 nM 
Reference: Mann, Doerthe, et al. "In vitro selection of DNA aptamers binding ethanolamine."   Biochemical and Biophysical Research Communication, 338 (2005): 1928-1934.    Tradmarked in patent, "New DNA aptamers specific for compunds that contain the ethylamino group, useful for diagnosis, prevention and treatment of ethanolaminosis, schizophrenia and neurodegeneration (Original document: DE 102005052275 (B4))"Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Streptavidin (31) (ID# 7471)
Aptamer chemistry: DNA
Aptamer sequence: ATACCAGCTTATTCAATTCTATACTCCACTTTGCTATTTCTCGGTTCCTTCACGCGCCGATCGCAGGCTGATGAATTGAGATAGTAAGTGCAATCT
Target: Streptavidin
Target chemistry: Protein
Affinity: 56.7 nM 
Reference: Stoltenburg et al. "FluMag-SELEX as an advantageous method for DNA aptamer selection." Analytical and Bioanalytical Chemistry, 383 (2005): 83-91.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: YPEN-1 Endothelial Cells (III.1) (ID# 7605)
Aptamer chemistry: DNA
Aptamer sequence: ATACCAGCTTATTCAATTAGGCGGTGCATTGTGGTTGGTAGTATACATGAGGTTTGGTTGAGACTAGTCGCAAGATATAGATAGTAAGTGCAATCT
Target: YPEN-1 Endothelial Cells
Target chemistry: Cells
Affinity: Not Mentioned in Database
Reference: Blank et al. "Systematic Evolution of a DNA Aptamer Binding to Rat Brain Tumor Microvessels." The Journal of Biological Chemistry, >b>276(2001): 16464-16468.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: 4-1BB ligand (M12-23) (ID# 7724)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGAGAGGAAGAGGGAUGGGCGACCGAACGUGCCCUUCAAAGCCGUUCACUAACCAGUGGCAUAACCCAGAGGUCGAUAGUACUGGAUCCCCCC
Target: 4-1BB ligand on CD8+ T Cells
Target chemistry: Protein
Affinity: 40 nM 
Reference: J. O. McNamara II et al.. Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice. J. Clin. Invest. 118(2008):376-386.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Anti Fumonsin B1 Toxin (ID# 7870)
Aptamer chemistry: DNA
Aptamer sequence: ATACCAGCTTATTCAATTAATCGCATTACCTTATACCAGCTTATTCAATTACGTCTGCACATACCAGCTTATTCAATTAGATAGTAAGTGCAATCT
Target: Fumonsin Toxin B1
Target chemistry: Protein
Affinity: 100 nM 
Reference: Mckeague et al. Screening and Initial Binding Assessment of Fumonisin B1   Aptamers: International Journal of Molecular SciencesMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: L-Arginine (ag.06) (ID# 7460)
Aptamer chemistry: RNA
Aptamer sequence: GGAGCUCAGCCUUCACUGCAUGAUAAACCGAUGCUGGGCGAUUCUCCUGAAGUAGGGGAAGAGUUGUCAUGUAUGGGGGCACCACGGUCGGAUCCUG
Target: L-Arginine
Target chemistry: Small Organic
Affinity: 330 nM 
Reference: Geiger, Albert, et al. "RNA aptamers that bind L-arginine with sub-micromolar dissociation constants and high enantioselectivity." Nucleic Acid Research, 24 (1996): 1029-1036.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: NF-kappa B (Aptamer 3) (ID# 7544)
Aptamer chemistry: RNA
Aptamer sequence: GGGAUAUCCUCGAGCAUAAGAAACAAGAUAGAUCCUGAAACUGUUUUAAGGUUGGCCGAUCUUCUGCUCGAGAAUGCAUGAAGCGUUCCAUAUUUUU
Target: NF-kappa B
Target chemistry: Protein
Affinity: 1 nM 
Reference: Lebriska and Maher. "Selection and Characterization of an RNA Decoy for Transcription Factor NF- B." Journal of Biochemistry, 38(1999): 3168-3174.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Mycobacterium tuberculosis (strain H37Rv) (aptamer NK2) (ID# 7788)
Aptamer chemistry: DNA
Aptamer sequence: GCGGGATCCTATGACGCATTGACCCACAACACACTACTGTCGCTCGGTTCGAACTTCGTGCGACTGTTCCCTATAGTGAGTCGTATTAGAATTCCGC
Target: Virulent mycobacterium tuberculosis (H37Rv)
Target chemistry: Protein
Affinity: 31 nM 
Reference: Fan et al. "Aptamer from whole-bacterium SELEX as new theraputic reagent against virulent Mycobacterium Tuberculosis." Biochem. Bioph. Res. Co.,  357, (2007): 743-748.     Fan et al. "Aptamer Inhibits Mycobacterium Tuberculosis (H37Rv) Invasion of Macrophage." Mol. Biol. Rep., 39, (2012): 2157-2162.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: GVI-11 (ID# 8084)
Aptamer chemistry: DNA
Aptamer sequence: GTCTGAAGTAGACGCAGGAGTCCGTCGGTTCGCCTTGCGAGTGCACGCCGCCAGCCGTTACATAAAGTCTGCCCACTAGTCACACCTGAGTAAGCGT
Target: GCRV-infected CIK
Target chemistry: Cells
Affinity: 278.66 nM 
Reference: Yu, Qing et al. “Generation and characterization of aptamers against grass carp reovirus infection for the development of rapid detection assay.” Journal of fish diseases vol. 44,1 (2021): 33-44. doi:10.1111/jfd.13265Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Co2+ (AR1) (ID# 7589)
Aptamer chemistry: RNA
Aptamer sequence: GGAUAAUAGCCGUAGGUUGCGAAAGCGACCCUGAUGAGAAAGCCAAAGCCGUAGCGCAGAUGAUCUCGCCAUCAGUACCGAAACGGUAGCGAGAGCUC
Target: Co2+
Target chemistry: Small Organic
Affinity: ~100 µM 
Reference: Seetharaman et al. "Immobolized RNA switches for the analysis of complex chemical and biological mixtures." Nature Biotechnology, 19(2001): 336-341.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Cd2+ (AR1) (ID# 7600)
Aptamer chemistry: RNA
Aptamer sequence: GGAUAAUAGCCGUAGGUUGCGAAAGCGACCCUGAUGAGAAAGCCAAAGCCGUAGCGCAGAUGAUCUCGCCAUCAGUACCGAAACGGUAGCGAGAGCUC
Target: Cd2+
Target chemistry: Small Organic
Affinity: ~100 µM 
Reference: Seetharaman et al. "Immobolized RNA switches for the analysis of complex chemical and biological mixtures." Nature Biotechnology, 19(2001): 336-341.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Ni2+ (AR1) (ID# 7601)
Aptamer chemistry: RNA
Aptamer sequence: GGAUAAUAGCCGUAGGUUGCGAAAGCGACCCUGAUGAGAAAGCCAAAGCCGUAGCGCAGAUGAUCUCGCCAUCAGUACCGAAACGGUAGCGAGAGCUC
Target: Ni2+
Target chemistry: Small Organic
Affinity: ~100 µM 
Reference: Seetharaman et al. "Immobolized RNA switches for the analysis of complex chemical and biological mixtures." Nature Biotechnology, 19(2001): 336-341.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Zn2+ (AR1) (ID# 7602)
Aptamer chemistry: RNA
Aptamer sequence: GGAUAAUAGCCGUAGGUUGCGAAAGCGACCCUGAUGAGAAAGCCAAAGCCGUAGCGCAGAUGAUCUCGCCAUCAGUACCGAAACGGUAGCGAGAGCUC
Target: Zn2+
Target chemistry: Small Organic
Affinity: ~100 µM 
Reference: Seetharaman et al. "Immobolized RNA switches for the analysis of complex chemical and biological mixtures." Nature Biotechnology, 19(2001): 336-341.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Mn2+ (AR1) (ID# 7603)
Aptamer chemistry: RNA
Aptamer sequence: GGAUAAUAGCCGUAGGUUGCGAAAGCGACCCUGAUGAGAAAGCCAAAGCCGUAGCGCAGAUGAUCUCGCCAUCAGUACCGAAACGGUAGCGAGAGCUC
Target: Mn2+
Target chemistry: Small Organic
Affinity: ~1 mM 
Reference: Seetharaman et al. "Immobolized RNA switches for the analysis of complex chemical and biological mixtures." Nature Biotechnology, 19(2001): 336-341.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HER-2 (S6) (ID# 7670)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGAUACCAGCUUAUUCAAUUUGGAUGGGGAGAUCCGUUGAGUAAGCGGGCGUGUCUCUCUGCCGCCUUGCUAUGGGGAGAUAGUAAGUGCAAUCU
Target: HER-2 (SK-BR-3 cell line)
Target chemistry: Cells
Affinity: 94.6 nM 
Reference: Kang, H. (2009). Isolation of RNA aptamers targeting Her-2-overexpressing breast cancer cells using cell-selex. Bull. Korean Chem. Soc., 30(8), 182-1831.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Kanamycin A (#13_82) (ID# 7862)
Aptamer chemistry: DNA
Aptamer sequence: ATACCAGCTTATTCAATTCAGGGCGGTATGAGGCTCGATCAAGGTCGGAGCGAGAATTTTTTCGCGGAGTCGGCTGGATCAGATAGTAAGTGCAATCT
Target: Kanamycin A
Target chemistry: Small Organic
Affinity: 5.1 nM 
Reference: Stoltenburg R, Nikolaus N, Strehlitz B.(2012) Capture-SELEX: Selection of DNA Aptamers for Aminoglycoside Antibiotics. J Anal Methods Chem. 2012:doi:10.1155/2012/415697Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Activated Protein C (APC 99) (ID# 7539)
Aptamer chemistry: RNA
Aptamer sequence: GUGAGACCAGCCGAGUGGUGUCUGGCUAUUCACUGGAGCGUGGGUGGAACCCCUGCGCACUCGUUUGGCUGUCCGGGCCUUCGGGCCGGGAUUAUCUCU
Target: Human Activated Protein C
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Gal, S., et al. "Selection of a RNA aptamer that binds to human activated protein C and inhibits its protease function." European Journal of Biochemistry, 252(1998): 553-562.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Caffeine (S2.caf.D11) (ID# 7651)
Aptamer chemistry: RNA
Aptamer sequence: GGAUGUCCAGUCGCUUGCAAUGCCCUUUUAGACCCUGAUGAGGAUCAUCGGACUUUGUCCUGUGGAGUAAGAUCGCGAAACGGUGAAAGCCGUAGGUCU
Target: Caffeine
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Ferguson et al. "A novel strategy for selection of allosteric ribozymes yields RiboReporter  TM sensors for caffeine and aspartame." Nucleic Acids Research, 32(2004): 1756-1766.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Aspartame (ID# 7652)
Aptamer chemistry: RNA
Aptamer sequence: GGAUGUCCAGUCGCUUGCAAUGCCCUUUUAGACCCUGAUGAGCGGUGCUAGUUAGUUGCAGUUUCGGUUGUUACGCGAAACGGUGAAAGCCGUAGGUCU
Target: Aspartame
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Ferguson et al. "A novel strategy for selection of allosteric ribozymes yields RiboReporter TM sensors for caffeine and aspartame." Nucleic Acids Research, 32(2004): 1756-1766.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: SECURA-3 (ID# 8082)
Aptamer chemistry: RNA
Aptamer sequence: GGAGCUCAGCCUUCACUGCGAUCACCGUGUCGGUGGCUAGUCGAUGUAUCCCGAUCACCAUUGGGGGCAAGUUUAGACAGGCACCACGGUCGGAUCCAC
Target: Pituitary tumour transforming gene 1 (PTTG1)
Target chemistry: Protein
Affinity: 16.41 ± 6.4 nM 
Reference: Prabu, S. S., Ch’ng, E. S., Woon, P. Y., Chen, J.-H., Tang, T.-H., & Citartan, M. (2020). Unravelling the diagnostic and therapeutic potentialities of a novel RNA aptamer isolated against human pituitary tumour transforming gene 1 (PTTG1) protein. Analytica Chimica Acta. doi:10.1016/j.aca.2020.09.038Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Cholic Acid (9) (ID# 7505)
Aptamer chemistry: DNA
Aptamer sequence: GTACCAGCTTATTCAATTACCGCGAAGAAGTGTCATTGTTTTGGAGATTCGAAGCGCTGTACACAGGTAATGAAGCCTTCTAAGATAGTATGTTCATCAG
Target: Cholic Acid
Target chemistry: Small Organic
Affinity: 50 pM 
Reference: Kato, T., et al. "In vitro selection of DNA aptamers which bind to cholic acid." Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1493 (2000):Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Arsenic(III) (Ars-3) (ID# 7825)
Aptamer chemistry: DNA
Aptamer sequence: GGTAATACGACTCACTATAGGGAGATACCAGCTTATTCAATTTTACAGAACAACCAACGTCGCTCCGGGTACTTCTTCATCGAGATAGTAAGTGCAATCT
Target: Arsenic(III)
Target chemistry: Small Organic
Affinity: 4.95 nM 
Reference: Kim, et al. "Arsenic Removal from Vietnamese Groundwater Using the Arsenic-Binding DNA Aptamer." Environ. Sci. Technol., 43 (2009): 9335-9340.    Wu et al. "Ultrasensitive Aptamer Biosensor for Arsenic(III) Detection in Aqueous Solution Based on Surfactant-Induced Aggregation of Gold Particles." Analyst, 137 (2012): 4171-4178.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.