rpgv/AptaCom huggingface dataset:
Aptamer: PFOA Aptamer (ID# 8177)
Aptamer chemistry: DNA
Aptamer sequence: GGAATCGTGGGTGGTAGGGTAGGGGATGCA
Target: Polyfluoroalkyl acid (Perfluorooctanoic acid, PFOA)
Target chemistry: Small Organic
Affinity: 5.5 nM 
Reference: Park, J., Yang, K.-A., Choi, Y., & Choe, J. K. (2022). Novel ssdna aptamer-based fluorescence sensor for perfluorooctanoic acid detection in water. Environment International, 158, 107000. https://doi.org/10.1016/j.envint.2021.107000Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HD1-15dA (ID# 8198)
Aptamer chemistry: DNA
Aptamer sequence: GGTTGGTGTGGTTGGAAAAAAAAAAAAAAA
Target: Thrombin
Target chemistry: Protein
Affinity: 50.9 nM 
Reference: Müller, J., Wulffen, B., Pötzsch, B., & Mayer, G. (2007). Multidomain Targeting Generates a High-Affinity Thrombin-Inhibiting Bivalent Aptamer. ChemBioChem, 8(18), 2223–2226. doi:10.1002/cbic.200700535Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: cAMP (ID# 7512)
Aptamer chemistry: RNA
Aptamer sequence: GGAAGAGAUGGCGACUAAAACGACUUGUCGC
Target: cAMP
Target chemistry: Small Organic
Affinity: 10 µM 
Reference: Kozumi and Breaker. "Molecular Recognition of cAMP by an RNA Aptamer." Biochemistry, 39 (2000): 8983-8992.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Thrombin (31mer) (D2-5) (ID# 7787)
Aptamer chemistry: DNA
Aptamer sequence: AGCGAGTAGGTTGGTGTGGTTGGGGCTCGCT
Target: Thrombin
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: K Ikebukuro et al. Analysis of the evolution of the thrombin-inhibiting DNA aptamers using a genetic algorithm. Biotechnol Lett (2006) 28:1933ƒ??1937.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: IL-6 Aptamer (ID# 8228)
Aptamer chemistry: DNA
Aptamer sequence: GGTGGCAGGAGGACTATTTATTTGCTTTTCT
Target: Interleukin 6 (IL-6)
Target chemistry: Protein
Affinity: Not given nM 
Reference: "A flexible multiplexed immunosensor for point-of-care in situ wound monitoring", Yuji Gao, et. al. (2021)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139589/pdf/abg9614.pdfMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: 2-17-2 (ID# 8236)
Aptamer chemistry: DNA
Aptamer sequence: TCAAGGTCGCAATTTCGAGCAGAACTTAAGA
Target: E. coli
Target chemistry: Cells
Affinity: 101.76+/-9.11 nM 
Reference: Mengyue Liu, Lingjun Geng, Fengjuan Zhang, Shouyi Dou, Falan Li, Zhanli Liu, Yemin Guo, and Xia SunJournal of Agricultural and Food Chemistry 2022 70 (50), 15990-15998DOI: 10.1021/acs.jafc.2c06167https://pubs.acs.org/doi/abs/10.1021/acs.jafc.2c06167?ref=PDFMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Xanthine (XAB) (ID# 7511)
Aptamer chemistry: RNA
Aptamer sequence: GGCACGUGUAUUACCCUAGUGGUCGACGUGCC
Target: Xanthine
Target chemistry: Small Organic
Affinity: 3.3 nM 
Reference: Kiga, D., et al. "An RNA aptamer to the xanthine/guanine base with a  distinctive mode of purine recognition." Nucleic Acids Research, 26 (1998): 1755-1760.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: L-Isoleucine (IL 42-32b) (ID# 7518)
Aptamer chemistry: RNA
Aptamer sequence: GGUCUUACGUCGUUCGCGACUAUUGGGAGACC
Target: L-Isoleucine
Target chemistry: Small Organic
Affinity: 200 µM 
Reference: Majerfeld and Yarus. "Isoleucine:RNA sites with associated coding sequence." RNA, 4 (1998): 471-478.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Vascular Permeability  Factor/Vascular  Endothelial  Growth  Factor (NX-213) (ID# 7547)
Aptamer chemistry: Chimeric
Aptamer sequence: TTTTACCCUGAUGGUAGACGCCGGGGUGTTTT
Target: Vascular Permeability  Factor/Vascular  Endothelial  Growth  Factor (VPF/VEGF)
Target chemistry: Protein
Affinity: 140 pM 
Reference: Green L, Jellinek D, Janjic N, et al. (1995) "Nuclease-resistant nucleic acid ligands to vascular permeability factor/vascular endothelial growth factor." Chem Biol. 2:683-695.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: PSA aptamer (PSap4#5) (ID# 7714)
Aptamer chemistry: DNA
Aptamer sequence: TTTTTAATTAAAGCTCGCCATCAAATAGCTTT
Target: PSA
Target chemistry: Protein
Affinity: <100 nM 
Reference: N Savory et al. Selection of DNA aptamer against prostate specific antigen using a genetic algorithm and application to sensing. Biosens. Bioelectron. 26 (2010): 1386-1391.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: p-Nosyl Protected Alkyl Amino Group (M6b-M14) (ID# 7824)
Aptamer chemistry: DNA
Aptamer sequence: ATCATGGTGGGTATCGGCACTCGTTGGTTGAT
Target: p-nosyl protected alkyl amino groups
Target chemistry: Small Organic
Affinity: 2.27 nM 
Reference: Mei H et al. (2012) Functional-group specific aptamers indirectly recognizing compounds with alkyl amino group. Anal. Chem. 84: 7323 - 7329Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: A-10 Excised Adenosine Aptamer (ID# 8043)
Aptamer chemistry: DNA
Aptamer sequence: GTATTGCGGAGGAAGGTTTTTAACCTTCGGGG
Target: Adenosine
Target chemistry: Small Organic
Affinity: 12.7-16.9 nM 
Reference: Li, Y., Liu, B., Huang, Z., & Liu, J. (2020). Engineering base-excised aptamers for highly specific recognition of adenosine. Chemical Science. doi:10.1039/d0sc00086hMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Aptamin C (ID# 8142)
Aptamer chemistry: DNA
Aptamer sequence: GTGGAGGCGGTGGCCAGTCTCGCGGTGGCGGC
Target: Vitamin C
Target chemistry: Small Organic
Affinity: 987.9 nM 
Reference: Chiu, A.S., Sankarapani, V., Drabek, R., Jackson, G.W., Batchelor, R.H. and Kim, Y., 2018. Inhibition of vitamin C oxidation by DNA aptamers. Aptamers, 2, pp.1-20.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: MS3 (ID# 8203)
Aptamer chemistry: DNA
Aptamer sequence: GGGAGGGAGGGAGGGAGGGAGGGAGGGAGGGAGGGA
Target: Huntingtin
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Riccardi C, D’Aria F, Digilio FA, Carillo MR, Amato J, Fasano D, De Rosa L, Paladino S, Melone MAB, Montesarchio D, Giancola C. Fighting the Huntington’s Disease with a G-Quadruplex-Forming Aptamer Specifically Binding to Mutant Huntingtin Protein: Biophysical Characterization, In Vitro and In Vivo Studies. International Journal of Molecular Sciences. 2022; 23(9):4804. https://doi.org/10.3390/ijms23094804Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Moloney Murine Leukemia Virus (ID# 7575)
Aptamer chemistry: RNA
Aptamer sequence: UUACCACGCGCUCUUAACUGCUAGCGCCAUGGC
Target: Moloney Murine Leukemia Virus (M-MLV) RT
Target chemistry: Protein
Affinity: 6.9 nM 
Reference: Chen and Gold. "Selection of High-Affinity RNA Ligands to Reverse Transcriptase: Inhibition of  cDNA Synthesis and RNase H Activity." Journal of Biochemistry, 33(1994): 8746-8756.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: IR-A48 (ID# 7957)
Aptamer chemistry: DNA
Aptamer sequence: CGCCTGGGAAGACAACCCAGGCAGGCG
Target: Insulin Receptor
Target chemistry: Protein
Affinity: 3.5 nM 
Reference: Yunn N, Koh A, Han S, Lim JH, Park S, et al. (2015) Agonistic Aptamer to the Insulin Receptor Leads to Biased Signaling and Functional Selectivity Through Allosteric Modulation. Nucleic Acids Research 1. doi:10.1093/narlgkv767Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: ex-50.T (ID# 8143)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: UGUGGCAGUUAAGAAUAGAUCUUCGCUGCGAUU
Target: Breast cancer exosomes
Target chemistry: Other
Affinity: 0.8 nM 
Reference: Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: TEPP (ID# 8144)
Aptamer chemistry: DNA
Aptamer sequence: GCGCGGTACCGCGCTAACGGAGGTTGCGTCCGT
Target: bEnd.3 and MDA-MB-231
Target chemistry: Cells
Affinity: 110-85.6 nM 
Reference: Macdonald, J., Denoyer, D., Henri, J., Jamieson, A., Burvenich, I. J., Pouliot, N., & Shigdar, S. (2020). Bifunctional aptamer–doxorubicin conjugate crosses the blood–brain barrier and selectively delivers its payload to EpCAM-positive tumor cells. Nucleic acid therapeutics, 30(2), 117-128.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: TEPP (ID# 8175)
Aptamer chemistry: DNA
Aptamer sequence: GCGCGGTACCGCGCTAACGGAGGTTGCGTCCGT
Target: Tfr (transferrin receptor) / EpCAM (epithelial cell adhesion molecule)
Target chemistry: Small Organic
Affinity: Tfr:  110\u2009±\u200922.0, EpCAM: 85.6\u2009±\u200928.5 nM 
Reference: Macdonald, J., Denoyer, D., Henri, J., Jamieson, A., Burvenich, I. J. G., Pouliot, N., and S. Shigar. 2020. Bifunctional Aptamer–Doxorubicin Conjugate Crosses the Blood–Brain Barrier and Selectively Delivers Its Payload to EpCAM-Positive Tumor Cells. Nucleic Acid Therapeutics 30:2: 117-128. DOI: 10.1089/nat.2019.0807Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Abrin Toxin (TA6) (ID# 7495)
Aptamer chemistry: DNA
Aptamer sequence: ATCCTGTGAGGAATGCTCATGCATAGCAAGGGCT
Target: Abrin Toxin
Target chemistry: Protein
Affinity: ~28 nM 
Reference: Tang, J., et al. "In vitro selection of DNA aptamer against abrin toxin and aptamer-based abrin direct detection." Biosensors and Bioelectronics, 22 (2007): 2456-2463.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Basic Fibroblast Growth Factor (26A-t) (ID# 7540)
Aptamer chemistry: RNA
Aptamer sequence: GGUGAAGGCAACGUAUAGGCAAGCACACUUCACC
Target: Basic Fibroblast Growth Factor (bFGF)
Target chemistry: Protein
Affinity: 190 pM 
Reference: Jellinek, D., et al. "High-affinity RNA ligands to basic fibroblast growth factor inhibit receptor binding." Proceedings of the National Academy of Sciences of the  United States of America, 90(1993): 11227ƒ??11231.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: ErbB2 (SE15-8) (ID# 7597)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: AGCCGCGAGGGGAGGGAUAGGGUAGGGCGCGGCU
Target: ErbB2 in Breast Cancer Cells
Target chemistry: Protein
Affinity: 3.49 nM 
Reference: Kim and Jeong. "In Vitro Selection of RNA Aptamer and Specific Targeting of ErbB2 in Breast Cancer Cells." Oligonucleotides, doi:10.1089/oli.2011.028.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: M64CA (ID# 7668)
Aptamer chemistry: DNA
Aptamer sequence: TTCGGGAATGATTATCAAATTTATGCCCTCTGAT
Target: MPT64 Protein
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Qin, L., et al.(2009). "The selection and application of ssDNA aptamers against MPT64 protein in Mycobacterium tuberculosis." Clin Chem Lab Med, 47(4), 405-411. doi: 10.1515/CCLM.2009.097Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: GL21.T (ID# 7907)
Aptamer chemistry: RNA
Aptamer sequence: AUGAUCAAUCGCCUCAAUUCGACAGGAGGCUCAC
Target: Axl tyrosine kinase receptor
Target chemistry: Protein
Affinity: 12 nM 
Reference: Laura Cerchia, Carla L Esposito, Simona Camorani, Anna Rienzo, Loredana Stasio,  Luigi Insabato, Andrea Affuso and Vittorio de Franciscis,"Targeting Axl With an High-affinity Inhibitory Aptamer". Molecular Therapy vol.20 no.12, 2291-2303, Dec2012.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Rd29C33-T7 (ID# 8070)
Aptamer chemistry: DNA
Aptamer sequence: GCACACCGATGGCGGTCCTGTTTAGGGGGTGTGC
Target: Melamine
Target chemistry: Small Organic
Affinity: 0.92-0.98 nM 
Reference: Gu, Chunmei et al. “Label-free fluorescence detection of melamine with a truncated aptamer.” The Analyst vol. 141,14 (2016): 4511-7. doi:10.1039/c6an00537cMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: IFN-γ-binding aptamer (ID# 8230)
Aptamer chemistry: DNA
Aptamer sequence: GGGGTTGGTTGTGTTGGGTGTTGTGTCCAACCCC
Target: IFN-γ
Target chemistry: Protein
Affinity: 3 nM 
Reference: Development of an aptamer beacon for detection of interferon-gamma. Tuleuova, et. al (2010)https://pubmed.ncbi.nlm.nih.gov/20121141/Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Cyanocobalamin (35-mer) (ID# 7513)
Aptamer chemistry: RNA
Aptamer sequence: CCGGUGCGCAUAACCACCUCAGUGCGAGCAAGGAA
Target: Cyanocobalamin
Target chemistry: Small Organic
Affinity: 88 nM 
Reference: Lorsch and Szostak. "In vitro selection of RNA aptamers specific for cyanocobalamin." Biochemistry, 33 (1994): 973-982.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: M64RA (ID# 7669)
Aptamer chemistry: DNA
Aptamer sequence: TGGGAGCTGATGTCGCATGGGTTTTGATCACATGA
Target: MPT64 Protein
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Qin, L., et al.(2009). "The selection and application of ssDNA aptamers against MPT64 protein in Mycobacterium tuberculosis." Clin Chem Lab Med, 47(4), 405-411. doi: 10.1515/CCLM.2009.097Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: SP6 RNA polymerase (S05) (ID# 7673)
Aptamer chemistry: RNA
Aptamer sequence: UUGCUUGGAAUGCGUUAUAGUCUCUUAGGUGUGUA
Target: SP6 RNA Polymerase
Target chemistry: Protein
Affinity: 9.5 nM 
Reference: Mori, Y. (2012). Inhibitory RNA aptamer against sp6 RNA polymerase. Biochemical and Biophysical Resarch Communications, 420 (2012), 440-443.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Interleukin 8 (8A-35) (ID# 7970)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGGGCUUAUCAUUCCAUUUAGUGUUAUGAUAACC
Target: Interleukin-8 (CXCL-8)
Target chemistry: Protein
Affinity: 1.72 pM 
Reference: Sung HJ, Choi S, Lee JW, Ok CY, Bae YS, Kim YH, Lee W, Heo K, Kim IH. Inhibition of human neutrophil activity by an RNA aptamer bound to interleukin-8. Biomaterials. 2014 Jan;35(1):578-89. doi: 10.1016/j.biomaterials.2013.09.107. Epub 2013 Oct 13.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Cd(II)-specific aptamer (CAP) (ID# 7979)
Aptamer chemistry: DNA
Aptamer sequence: GGGGACTGTTGTGGTATTATTTTTGGTTGTGCAGT
Target: Cadmium (II)
Target chemistry: Other
Affinity: 2.15 nM 
Reference: Zhu, YF., Wang, YS., Zhou, B. et al. Anal Bioanal Chem (2017). doi:10.1007/s00216-017-0436-1.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: 1501s malaria aptamer (ID# 8025)
Aptamer chemistry: DNA
Aptamer sequence: GGTATAGACCCCTGAGTCCTACCGAGGGCACGGCA
Target: PvLDH (Malaria)
Target chemistry: Protein
Affinity: 670 nM 
Reference: Cheung, Y.-W., Röthlisberger, P., Mechaly, A. E., Weber, P., Levi-Acobas, F., Lo, Y., … Tanner, J. A. (2020). Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker. Proceedings of the National Academy of Sciences, 202003267. doi:10.1073/pnas.2003267117Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: SW1A (ID# 8183)
Aptamer chemistry: DNA
Aptamer sequence: AGGCCCGCCGGGTGGGTGGGGGGGTTTGCGGGCCT
Target: SMMC-7721 cells (liver cancer)
Target chemistry: Protein
Affinity: 123.62 ± 17.53 nM 
Reference: Li, L., Wan, J., Wen, X., Guo, Q., Jiang, H., Wang, J., … Wang, K. (2021). Identification of a New DNA Aptamer by Tissue-SELEX for Cancer Recognition and Imaging. Analytical Chemistry, 93(19), 7369–7377. doi:10.1021/acs.analchem.1c01445Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: SL1108_18 (ID# 8242)
Aptamer chemistry: DNA
Aptamer sequence: TCGGAATGAATGTCTGCCTTGCACTGGTGCGGTCC
Target: RBD of SARS-COV-2 Spike protein (monomer or trimer)
Target chemistry: Protein
Affinity: 0.4-0.6 nM 
Reference: Gelinas, A. D., Tan, T. K., Liu, S., Jaramillo, J. G., Chadwick, J., Harding, A. C., Zhang, C., Ream, B. E., Chase, C. N., Otis, M. R., Lee, T., Schneider, D. J., James, W. S., & Janjic, N. (2023). Broadly neutralizing aptamers to SARS-COV-2: A diverse panel of modified DNA antiviral agents. Molecular Therapy - Nucleic Acids, 31, 370–382. https://doi.org/10.1016/j.omtn.2023.01.008Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Plasmodium vivax lactate dehydrogenase (pL1) (ID# 7693)
Aptamer chemistry: DNA
Aptamer sequence: GTTCGATTGGATTGTGCCGGAAGTGCTGGCTCGAAC
Target: Plasmodium vivax lactate dehydrogenase  (PvLDH)
Target chemistry: Protein
Affinity: 16.8 nM 
Reference: Seonghwan, L. (2012). A highly sensitive aptasensor towards plasmodium lactate dehydrogenase for the diagnosis of malaria. Biosensors and Bioelectronics, 35(2012), 291-296.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Plasmodium falciparum lactate dehydrogenase  (pL1) (ID# 7694)
Aptamer chemistry: DNA
Aptamer sequence: GTTCGATTGGATTGTGCCGGAAGTGCTGGCTCGAAC
Target: Plasmodium falciparum lactate dehydrogenase  (PfLDH)
Target chemistry: Protein
Affinity: 38.7 nM 
Reference: Seonghwan, L. (2012). A highly sensitive aptasensor towards plasmodium lactate dehydrogenase for the diagnosis of malaria. Biosensors and Bioelectronics, 35(2012), 291-296.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Human Matrix Metalloprotease 9 (hMMP-9) (F3Bomf) (ID# 7743)
Aptamer chemistry: Chimeric
Aptamer sequence: UGCCCUGCCCUCACCCGUUAGCCUGAGCGCCCCGCA
Target: Human matrix metalloprotease 9 (hMMP-9)
Target chemistry: Protein
Affinity: 20 nM 
Reference: S Gomes et al. A 99mTc-MAG3-aptamer for imaging human tumours associated with high level of matrix metalloproteinase-9. Bioconjugate Chem. (2012). Accepted for print. DOI: 10.1021/bc300146c.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Lysozyme Aptamer (ID# 7975)
Aptamer chemistry: DNA
Aptamer sequence: TTTTTTATCAGGGCTAAAGAGTGCAGAGTTACTTAG
Target: Lysozyme
Target chemistry: Protein
Affinity: N/A µM 
Reference: J Zhao et al. High-Resolution and Universal Visualization of Latent Fingerprints Based on Aptamer-Functionalized Core-Shell Nanoparticles with Embedded SERS Reporters. ACS Appl. Mater. Interfaces 8(2016): 14389-14395.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: E. Coli 5S RNA (Helix 89 RNA) (ID# 7516)
Aptamer chemistry: RNA
Aptamer sequence: GGUGAUACCGCCCAAGAGUUCAUAUCGACGGCGGUGU
Target: E. Coli 5S RNA
Target chemistry: Small Organic
Affinity: 3 µM 
Reference: Ko, J. et al. "Identification of a structural motif of 23S rRNA interacting with 5S rRNA." FEBS Letters, 508 (2001): 300-304.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Daunomycin (10.10) (ID# 7586)
Aptamer chemistry: DNA
Aptamer sequence: ACCATCTGTGTAAGGGGTAAGGGGTGGGGGTACGTCT
Target: Daunomycin
Target chemistry: Small Organic
Affinity: 272 nM 
Reference: Wochner et al. "A DNA aptamer with high affinity and specificity for therapeutic anthracyclines." Analytical Biochemistry, 373(2008): 34-42.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Endothelial Integrin Alpha-V Beta-3 (Clone 17.16) (ID# 7613)
Aptamer chemistry: RNA
Aptamer sequence: UUCAACGCUGUGAAGGGCUUAUACGAGCGGAUUACCC
Target: Alpha-V Beta-3
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Brunette et al. "RNA Aptamer Therapy for Vaso-Occlusion in Sickle Cell Disease." Nucleic Acids Therapeutics, 21(2011): 275-283.    Mi et al. "Targeted inhibition of av??3 integrin with an RNA aptamer impairs endothelial cell growth and survival." Biochemical and Biophysical Research Communications, 338(2005): 956-963.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Membrane-Bound IgM (TD05.17) (ID# 7717)
Aptamer chemistry: Chimeric
Aptamer sequence: AGGAGGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCT
Target: Membrane-bound IgM (mIgM )/ B-cell receptor (BCR )/ Leukemia / Lymphoma
Target chemistry: Protein
Affinity: 43 nM 
Reference: R Mallikaratchy et al. "A multivalent DNA aptamer specific for the B-cell receptor on human lymphoma and leukemia." Nucleic Acids Res. 39(2011): 2458-2469.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HIV-1 Tat protein (ID# 7730)
Aptamer chemistry: RNA
Aptamer sequence: ACGAAGCUUGAUCCCGUUUGCCGGUCGAUCGCUUCGA
Target: HIV-1 Tat protein
Target chemistry: Protein
Affinity: 120 pM 
Reference: R Yamamoto et al. A novel RNA motif that binds efficiently and specifically to the Tat protein of HIV and inhibits the trans-activation by Tat of transcription in vitro and in vivo. Genes to Cells 5(2000):371-388Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: PC 12-31 (ID# 8009)
Aptamer chemistry: DNA
Aptamer sequence: CCCTCCGGGGGGGTCATCGGGATACCTGGTAAGGATA
Target: Escherichia Coli (E.Coli)
Target chemistry: Other
Affinity: 87.03 nM 
Reference: S. Marton, F. Cleto, M.A. Krieger, J. Cardoso, Isolation of an aptamer that binds specifically to E. coli, PLoS One. 11 (2016) 1–17, https://doi.org/10.1371/journal.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.