rpgv/AptaCom huggingface dataset:
Aptamer: L-Arginine(44Arg11) (ID# 7583)
Aptamer chemistry: RNA
Aptamer sequence: GACGAGAAGGAGCGCUGGUUCUACUAGCAGGUAGGUCACUCGUC
Target: L-Arginine
Target chemistry: Small Organic
Affinity: 60 nM 
Reference: Famulok, M., " Molecular Recognition of Amino Acids by RNA-Aptamers: An L-Citrulline Binding RNA Motif and its Evolution into an L-Arginine Binder." Journal of the American Chemical Society, 116 (1994): 1698-1706.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Thyroxine (ApT4-A’) (ID# 7585)
Aptamer chemistry: RNA
Aptamer sequence: GGUGGAGGGGGACGUGCUGCAUCCGCAGUGCGUCUUGGGUUGUG
Target: Thyroxine
Target chemistry: Small Organic
Affinity: 50 µM 
Reference: Levesque et al. "In vitro selection and characterization of RNA aptamers binding thyroxine hormone." Biochemical Journal, 403(2007): 129-138.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: C-Reactive Protein (ID# 7819)
Aptamer chemistry: RNA
Aptamer sequence: GCCUGUAAGGUGGUCGGUGUGGCGAGUGUGUUAGGAGAGAUUGC
Target: C-Reactive Protein (CRP)
Target chemistry: Protein
Affinity: 125 nM 
Reference: A Bini, M Mascini, et al. Development of an optical RNA-based aptasensor for C-reactive protein. Anal. Bioanal. Chem. 390(2008): 1077-1088Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Enthalpy Driven Aptamer SYL-H2C (ID# 8044)
Aptamer chemistry: DNA
Aptamer sequence: GAGCTCGGGGTTTGGGGGTTCGGGGTCGGTTCGGTTTCTT
Target: EpCAM
Target chemistry: Protein
Affinity: 34.7 nM 
Reference: Huang, M., Song, J., Huang, P., Chen, X., Wang, W., Zhu, Z., Song, Y., & Yang, C. (2019). Molecular Crowding Evolution for Enabling Discovery of Enthalpy-Driven Aptamers for Robust Biomedical Applications. Analytical Chemistry, 91(16), 10879–10886. https://doi.org/10.1021/acs.analchem.9b02697Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Glucose-bisboronic acid aptamer-sensor (ID# 8045)
Aptamer chemistry: DNA
Aptamer sequence: CTCTCGGGACGACAGCCGAGTTGATTCAACAGCCGAGTCGTCCC
Target: Glucose
Target chemistry: Small Organic
Affinity: 5 nM 
Reference: Yang KA, Barbu M, Halim M, et al. Recognition and sensing of low-epitope targets via ternary complexes with oligonucleotides and synthetic receptors. Nat Chem. 2014;6(11):1003-1008. doi:10.1038/nchem.2058Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: S3 (ID# 8057)
Aptamer chemistry: DNA
Aptamer sequence: TCTGAGAATAGTGGTTTGCTGTATGGTGGGCGTTGAAAGAGGGG
Target: CD109
Target chemistry: Protein
Affinity: 10.5332 - 13.3326 nM 
Reference: Xiong, H., Yan, J., Cai, S., He, Q., Peng, D., Liu, Z., & Liu, Y. (2019). Cancer protein biomarker discovery based on nucleic acid aptamers. International Journal of Biological Macromolecules. doi:10.1016/j.ijbiomac.2019.03.165Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Tb-L8 (ID# 8062)
Aptamer chemistry: DNA
Aptamer sequence: GGTGTGGGCGACATGGGGGTTGGTGGTGTAGGAGCGCCAT
Target: Thrombin
Target chemistry: Protein
Affinity: 33 nM 
Reference: Qiao, N., Li, J., Wu, X., Diao, D., Zhao, J., Li, J., … Lou, X. (2019). Speeding up in vitro Discovery of Structure-Switching Aptamers via Magnetic Cross-Linking Precipitation. Analytical Chemistry. doi:10.1021/acs.analchem.9b00081Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Human Neutrophil Elastase (DNA I) (ID# 7576)
Aptamer chemistry: DNA
Aptamer sequence: TAGCGATACTGCGTGGGTTGGGGCGGGTAGGGCCAGCAGTCTCGT
Target: Human Neutrophil Elastase (HNE)
Target chemistry: Protein
Affinity: 17 nM 
Reference: Lin et al. "Peptide conjugation to an in vitro-selected DNA ligand improves enzyme inhibition." PNAS, 92(1995): 11044-11048.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Anti-IgE Aptamer, D 17.4 ext (ID# 7666)
Aptamer chemistry: DNA
Aptamer sequence: GCGCGGGGCACGTTTATCCGTCCCTCCTAGTGGCGTGCCCCGCGC
Target: IgE (human)
Target chemistry: Protein
Affinity: 3.6 nM 
Reference: Aptamer Selection Reference: Wiegand, T.W., et al. "High-Affinity Oligonucleotide Ligands to Human IgE Inhibit Binding to FCE Receptor I." Journal of Immunology, 157 (1996): 221-230  Liss, M., et al. "An Aptamer-Based Quartz Crystal Protein Biosensor." Anal. Chem.,74 (2002): 4488-4495.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: 20-10 (ID# 8013)
Aptamer chemistry: DNA
Aptamer sequence: TATGGCGTGGCAAGCTTGGCCCGCTTCTCAAGCATGGTTATCTAC
Target: E. coli
Target chemistry: Cells
Affinity: 10.1 nM 
Reference: Kim HR, Song MY, Chan Kim B. Rapid isolation of bacteria-specific aptamers with a non-SELEX-based method. Analytical Biochemistry. 2020 Feb;591:113542. DOI: 10.1016/j.ab.2019.113542.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: VA 6 (ID# 8014)
Aptamer chemistry: DNA
Aptamer sequence: CGACCTTAGCCTATGTTTTCTCTACCGGCTATGTTACGCGGGTCG
Target: VEGF165
Target chemistry: Protein
Affinity: 71 nM 
Reference: Lee, K.H., Zeng, H. A general double library SELEX strategy for aptamer selection using unmodified nonimmobilized targets. Anal Bioanal Chem 409, 5081–5089 (2017).Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: 20-7 (ID# 8015)
Aptamer chemistry: DNA
Aptamer sequence: CGCAATACCAAAGTGGCGAGAGCGCTGTCTTGAGTGAGTGGTTGG
Target: E. coli
Target chemistry: Cells
Affinity: 8.0 nM 
Reference: Kim HR, Song MY, Chan Kim B. Rapid isolation of bacteria-specific aptamers with a non-SELEX-based method. Analytical Biochemistry. 2020 Feb;591:113542. DOI: 10.1016/j.ab.2019.113542.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: 20-5 (ID# 8016)
Aptamer chemistry: DNA
Aptamer sequence: ATTTCGCCCCCGTGTTCCGACTGGTATCTTCACGTCTTCGAGTGT
Target: E. coli
Target chemistry: Cells
Affinity: 3.9 nM 
Reference: Kim HR, Song MY, Chan Kim B. Rapid isolation of bacteria-specific aptamers with a non-SELEX-based method. Analytical Biochemistry. 2020 Feb;591:113542. DOI: 10.1016/j.ab.2019.113542.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Mango III A10U (ID# 8021)
Aptamer chemistry: RNA
Aptamer sequence: GGCACGUACGAAGGAAGGUUUGGUAUGUGGUAUAUUCGUACGUGC
Target: Thiazole Orange - Biotin (TO1-Biotin)
Target chemistry: Small Organic
Affinity: 1.7 nM 
Reference: Trachman, R. J., Autour, A., Jeng, S. C. Y., Abdolahzadeh, A., Andreoni, A., Cojocaru, R., … Ferré-D’Amaré, A. R. (2019). Structure and functional reselection of the Mango-III fluorogenic RNA aptamer. Nature Chemical Biology, 15(5), 472–479. doi:10.1038/s41589-019-0267-9Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Aptamer A1 (ID# 8032)
Aptamer chemistry: DNA
Aptamer sequence: CCTGCCTTTGGAACCGACCGCCAGGCCGAGGAAAGGCACCGACAGC
Target: HA protein of CJ01 H1N1 Influenza Virus
Target chemistry: Protein
Affinity: 3.36 nM 
Reference: Kwon, J., Narayan, C., Kim, C., Han, M. J., Kim, M., & Jang, S. K. (2019). Development of a Subtype-Specific Diagnostic System for Influenza Virus H3N2 Using a Novel Virus-Based Systematic Evolution of Ligands by Exponential Enrichment (Viro-SELEX). Journal of Biomedical Nanotechnology, 15(7), 1609–1621. https://doi.org/10.1166/jbn.2019.2789 Gold L, Ayers D, Bertino J, Bock C, Bock A, Brody EN, et al. (2010) Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery. PLoS ONE 5(12): e15004. https://doi.org/10.1371/journal.pone.0015004Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: XA1 (ID# 8158)
Aptamer chemistry: DNA
Aptamer sequence: CTTACGACTGTGGTCGGGTGGTGGGCCTCTAGAGGGGTGTCGTAAG
Target: XLR-11
Target chemistry: Small Organic
Affinity: 310 nM 
Reference: Yu, H., Luo, Y., Alkhamis, O., Canoura, J., Yu, B., & Xiao, Y. (2021). Isolation of Natural DNA Aptamers for Challenging Small-Molecule Targets, Cannabinoids. Analytical chemistry, 93(6), 3172–3180. https://doi.org/10.1021/acs.analchem.0c04592Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Aptamer MA (ID# 8176)
Aptamer chemistry: DNA
Aptamer sequence: CTTACGACTCAGGCATTTTGCCGGGTAACGAAGTTACTGTCGTAAG
Target: methylenedioxypyrovalerone (MDPV)
Target chemistry: Small Organic
Affinity: 7 nM 
Reference: Haixiang Yu, Weijuan Yang, Obtin Alkhamis, Juan Canoura, Kyung-Ae Yang, Yi Xiao, In vitro isolation of small-molecule-binding aptamers with intrinsic dye-displacement functionality, Nucleic Acids Research, Volume 46, Issue 8, 4 May 2018, Page e43, https://doi.org/10.1093/nar/gky026Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: CoV2-6C3 (ID# 8195)
Aptamer chemistry: DNA
Aptamer sequence: CGCAGCACCCAAGAACAAGGACTGCTTAGGATTGCGATAGGTTCGG
Target: SARS-CoV-2 Spike Protein RBD
Target chemistry: Protein
Affinity: 44.78 nM 
Reference: Sun, M., Liu, S., Wei, X., Wan, S., Huang, M., Song, T., Lu, Y., Weng, X., Lin, Z., Chen, H., Song, Y., & Yang, C. (2021). Aptamer Blocking Strategy Inhibits SARS-CoV-2 Virus Infection. Angewandte Chemie (International ed. in English), 60(18), 10266–10272. https://doi.org/10.1002/anie.202100225Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Internalin A of Listeria monocytogenes (ID# 7769)
Aptamer chemistry: DNA
Aptamer sequence: ATCCATGGGGCGGAGATGAGGGGGAGGAGGGCGGGTACCCGGTTGAT
Target: Internalin A (InlA)
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: S.H. Ohk et al. Antibody-aptamer functionalized fibre-optic biosensor for specific detection of Listeria monocytogenes from food. J. Appl. Microbiol. 109(2010): 808-817.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: S21 (ID# 8065)
Aptamer chemistry: DNA
Aptamer sequence: GAGGCTCTCACATCGCGCCTTTCCCCAGCTTTCGGTGTGAGAGCCTC
Target: Cas9
Target chemistry: Protein
Affinity: 0.63 nM 
Reference: Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: NC3S (ID# 8079)
Aptamer chemistry: DNA
Aptamer sequence: TTGCACTATGTTTTAGCTAGGGTTCCCTCCGGAGATAGTAAGTGCAA
Target: N‑Cadherin
Target chemistry: Protein
Affinity: 20.08 ± 0.72 nM 
Reference: Gao T , Ding P , Li W , Wang Z , Lin Q , Pei R . Isolation of DNA aptamers targeting N-cadherin and high-efficiency capture of circulating tumor cells by using dual aptamers. Nanoscale. 2020 Nov 19;12(44):22574-22585. doi: 10.1039/d0nr06180h. PMID: 33174555.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Apt-07S (ID# 8108)
Aptamer chemistry: DNA
Aptamer sequence: GTACTGTCAATTGGAAGTGGTGTTACGTTGTGTAGTCAAATCAGTGC
Target: HepG2 (Kd = 194.7nM) and SMMC-7721 (Kd = 224.2nM)
Target chemistry: Cells
Affinity: 194.7 and 224.2 nM 
Reference: Yu XX, Ge KL, Liu N, Zhang JY, Xue ML, Ge YL. Selection and Characterization of a Novel DNA Aptamer, Apt-07S Specific to Hepatocellular Carcinoma Cells. Drug Des Devel Ther. 2020 Apr 20;14:1535-1545. doi: 10.2147/DDDT.S244149. PMID: 32368012; PMCID: PMC7182459.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: THC1.2 (ID# 8156)
Aptamer chemistry: DNA
Aptamer sequence: CTTACGACCCAGGGGGGTGGACAGGCGGGGGTTAGGGGGGTCGTAAG
Target: THC
Target chemistry: Small Organic
Affinity: 40 nM 
Reference: Yu, H., Luo, Y., Alkhamis, O., Canoura, J., Yu, B., & Xiao, Y. (2021). Isolation of Natural DNA Aptamers for Challenging Small-Molecule Targets, Cannabinoids. Analytical chemistry, 93(6), 3172–3180. https://doi.org/10.1021/acs.analchem.0c04592Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Acetylcholine Receptor Antibody (mAB198) (SE RNA VII) (ID# 7482)
Aptamer chemistry: 2'-NH2-RNA
Aptamer sequence: UGGGCCGGAGGUUAGCUUGCCCAUGGCAAGCAGGGCGCCACGGACCCA
Target: Acetylcholine Receptor Antibody (mAB198)
Target chemistry: Protein
Affinity: 60 nM 
Reference: Lee, Seong-Wook and Sullenger, Bruce. "Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies." Nature Biotechnology, 15 (1997): 41-45.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Anti-acetylcholine Autoantibodies (SE RNA) (ID# 7538)
Aptamer chemistry: 2'-NH2-RNA
Aptamer sequence: UGGGCCGGAGGUUAGCUUGCCCAUGGCAAGCAGGGCGCCACGGACCCA
Target: Anti-acetylcholine Autoantibodies
Target chemistry: Protein
Affinity: 60 nM 
Reference: Lee and Sullenger. "Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies." Nature Biotechnology, 15(1997):Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Ramos Cells (TD05) (ID# 7664)
Aptamer chemistry: DNA
Aptamer sequence: AACACCGTGGAGGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCCGGTG
Target: Ramos Cells (B-cell lymphoma cell line)
Target chemistry: Cells
Affinity: 74.7 nM 
Reference: Tang et al. "Selection of Aptamers for Molecular Recognition  and Characterization of Cancer Cells." Analytical Chemistry, 79(2007): 4900-4907.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Histone (H4K16Ac) (ID# 7722)
Aptamer chemistry: DNA
Aptamer sequence: AGACGTAAGTTAATTGGACTTGGTCGTGTGCGGCACAGCGATTGAAAT
Target: H4K16Ac
Target chemistry: Peptide
Affinity: 47 nM 
Reference: Lin et al. "Recognition Imaging of Acetylated Chromatin Using a DNA Aptamer." Biophysical Journal, 97(2009): 1804-07.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: hVap1_Stem (ID# 7922)
Aptamer chemistry: DNA
Aptamer sequence: TCTAGCCCACTGCATAGAGGTAGCCACGTATGTTCGTGGCTACCGGTG
Target: VEGF
Target chemistry: Protein
Affinity: 5.6 nM 
Reference: Meng, Hsein-Wei, and John Pagano. "Discovering Aptamers by Cell-SELEX against Human Soluble Growth Factors Ectopically Expressed on Yeast Cell Surface." Plos-One 9.3 (2014): 1-12. Print.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Beta-Estradiol Aptamer (BES.1) (ID# 7961)
Aptamer chemistry: DNA
Aptamer sequence: GGCTCTCGGGACGACATGGATTTTCCATCAACGAAGTGCGTCCGTCCC
Target: Beta-Estradiol (Estrogen)
Target chemistry: Small Organic
Affinity: 6 µM 
Reference: Yang K, Pei R, Stefanovic D, Stojanovic M.N. (2011) Optimizing Cross-reactivity with Evolutionary Search for Sensors. J. Am. Chem. Soc.134:1642-1647.
Aptamer: Epithelial Cell Adhesion Molecule (EpCAM) SYL3C (ID# 7980)
Aptamer chemistry: DNA
Aptamer sequence: CACTACAGAGGTTGCGTCTGTCCCACGTTGTCATGGGGGGTTGGCCTG
Target: Cancer Cells
Target chemistry: Cells
Affinity: 38 nM 
Reference: Selection of DNA Aptamers against Epithelial Cell Adhesion Molecule for Cancer Cell Imaging and Circulating Tumor Cell Capture  Yanling Song, Zhi Zhu, Yuan An, Weiting Zhang, Huimin Zhang, Dan Liu, Chundong Yu, Wei Duan, and Chaoyong James Yang  Analytical Chemistry 2013 85 (8), 4141-4149  DOI: 10.1021/ac400366bMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: PSMA Aptamer (SZTI01) (ID# 8017)
Aptamer chemistry: DNA
Aptamer sequence: GCGTTTTCGCTTTTGCGTTTTGGGTCATCTGCTTACGATAGCAATGCT
Target: Prostate-specific membrane antigen (PSMA)
Target chemistry: Protein
Affinity: Unknown  
Reference: Boyacioglu, O., Stuart, C. H., Kulik, G., & Gmeiner, W. H. (2013). Dimeric DNA Aptamer Complexes for High-capacity–targeted Drug Delivery Using pH-sensitive Covalent Linkages. Molecular Therapy - Nucleic Acids, 2, e107. doi:10.1038/mtna.2013.37Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: C10 (ID# 8026)
Aptamer chemistry: DNA
Aptamer sequence: CCCGGGTGTGGTGGGTGGGCAGGGGGGTTAGCATCTCACCAGCTCCGCA
Target: CD19+
Target chemistry: Protein
Affinity: 49.6 nM 
Reference: Mayer, Gunter, et al.  “Fluorescence-activated cell sorting for aptamer SELEX with cell mixtures.”  Nature Protocols 5, (2010): 1993-2004.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: EAg3-Py (ID# 8034)
Aptamer chemistry: DNA
Aptamer sequence: TTTTTTTTGGGCGAAGACCGGGACGGGAGGAAAGAGATGTTTGGTTTT
Target: Hepatitis B - E Antigen (HBeAg)
Target chemistry: Protein
Affinity: 0.4 nM 
Reference: Aptamer Binding Assay for the E Antigen of Hepatitis B Using Modified Aptamers with G-Quadruplex StructuresYanming Liu, Connie Le, D. Lorne Tyrrell, X. Chris Le, and Xing-Fang LiAnalytical Chemistry 2020 92 (9), 6495-6501DOI: 10.1021/acs.analchem.9b05740Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: L-Tyrosinamide (pe35) (ID# 7519)
Aptamer chemistry: DNA
Aptamer sequence: AATTCGCTAGCTGGAGCTTGGATTGATGTGGTGTGTGAGTGCGGTGCCC
Target: L-Tyrosinamide
Target chemistry: Small Organic
Affinity: 45 µM 
Reference: Vianini et al. "In vitro selection of DNA aptamers that bind L-tyrosinamide." Bioorganic & Medicinal Chemistry, 9 (2001): 2543-2548.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: NAD (ID# 7552)
Aptamer chemistry: RNA
Aptamer sequence: GGAACCCAACUAGGCGUUUGAGGGGAUUCGGCCACGGUAACAACCCCUC
Target: NAD
Target chemistry: Small Organic
Affinity: 2.5 nM 
Reference: Lauhon and Szostak. "RNA Aptamers That Bind Flavin and Nicotinamide Redox Cofactors." Journal of the American Chemical Society, 117(1994): 1246-1257.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: NADH (ID# 7667)
Aptamer chemistry: RNA
Aptamer sequence: GGAACCCAACUAGGCGUUUGAGGGGAUUCGGCCACGGUAACAACCCCUC
Target: NADH
Target chemistry: Small Organic
Affinity: 37 nM 
Reference: Lauhon and Szostak. "RNA Aptamers That Bind Flavin and Nicotinamide Redox Cofactors." Journal of the American Chemical Society, 117(1994): 1246-1257.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: DNA Blocker (Part of Lysozyme Aptasensor) (ID# 7703)
Aptamer chemistry: DNA
Aptamer sequence: ATCTACGAATTCATCAGGGCTAAAGAGTGCAGAGTTACTTAGCCCGTGA
Target: Lysozyme
Target chemistry: Other
Affinity: Not Mentioned in Database
Reference: Fu et al. "An ultrasensitive peroxidase DNAzyme-associated aptasensor that utilizes a target-triggered enzymatic signal amplification strategy." Chemical Communications, 47(2011): 9876-9878.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Carcinoembryonic Antigen Aptamer (YJ-1) (ID# 7712)
Aptamer chemistry: Chimeric
Aptamer sequence: GCGGAAGCGUGCUGGGCUAGAAUAAUAAUAAGAAAACCAGUACUUUCGU
Target: Carcinoembryonic Antigen (CEA)
Target chemistry: Protein
Affinity: 0.77 nM 
Reference: YJ Lee et al. An RNA aptamer that binds carcinoembryonic antigen inhibits hepatic metastasis of colon cancer cells in mice. Gastroenterology 143(2012): 155-165.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: L-Selectin (LD201t1) (ID# 7772)
Aptamer chemistry: DNA
Aptamer sequence: TAGCCAAGGTAACCAGTACAAGGTGCTAAACGTAATGGCTTCGGCTTAC
Target: L-Selectin binding to sialyl Lewis X
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Hicke, Brain, et al. "DNA Aptamers Block L-Selectin Function In Vivo Inhibition of Human Lymphocyte Traf?cking in SCID Mic." Journal of Clinical Investigation, 98 (1996): 2688-2692Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: L-Selectin Multivalent Aptamer (ID# 7951)
Aptamer chemistry: DNA
Aptamer sequence: TAGCCAAGGTAACCAGTACAAGGTGCTAAACGTAATGGCTTCGGCTTAC
Target: L-Selectin
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Chang EK, Eckert MA, Ali MM, Riazifar H, Pone EJ, Liu L, et al. (2015) Facile Supermolecular Aptamer Inhibitors of L-Selectin. PLoS ONE 10(3): e0123034. doi:10.1371/journal.pone.0123034Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Acetamiprid Binding Aptamer (S18) (ID# 8001)
Aptamer chemistry: DNA
Aptamer sequence: TGTAATTTGTCTGCAGCGGTTCTTGATCGCTGACACCATATTATGAAGA
Target: Acetamiprid
Target chemistry: Small Organic
Affinity: 4.98 µM 
Reference: Isolation and Identification of the DNA Aptamer Target to AcetamipridJiang He, Yuan Liu, Mingtao Fan, and Xianjin LiuJournal of Agricultural and Food Chemistry 2011 59 (5), 1582-1586DOI: 10.1021/jf104189gMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Gonadotropin-releasing hormone 1 (A10) (ID# 7492)
Aptamer chemistry: L-RNA
Aptamer sequence: CGGCCGAUAGAAAGACUACUUGAGCCCUUAAAUGAGGUUAUGUGCGGCCG
Target: Gonadoliberin/Gonadotropin-releasing hormone 1 (GnRH)
Target chemistry: Peptide
Affinity: 190 nM 
Reference: Leva, S., et al. "GnRH Binding RNA and DNA Spiegelmers: A Novel Approach toward GnRH Antagonism." Chemistry and Biology, 9 (2002): 351-359.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Receptor Tyrosine Kinase (RET) Mutant (D4) (ID# 7500)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GCGCGGGAAUAGUAUGGAAGGAUACGUAUACCGUGCAAUCCAGGGCAACG
Target: Receptor Tyrosine Kinase (RET) Mutant
Target chemistry: Protein
Affinity: 35 nM 
Reference: Cerchia, Laura, et al. "Neutralizing Aptamers from Whole-Cell SELEX Inhibit the RET Receptor Tyrosine Kinase." PLoS Biology, 3 (2004): e123Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.