rpgv/AptaCom huggingface dataset:
Aptamer: Antibac 2 (ID# 7977)
Aptamer chemistry: DNA
Aptamer sequence: TCGCGCGAGTCGTCTGGGGGACTAGAGGACTTGTGCGGCCCCGCATCGTCCTCCC
Target: peptidoglycan
Target chemistry: Other
Affinity: 195.9 nM 
Reference: A Graziani et al. High efficiency binding aptamers for a wide range of sepsis 1 bacterial agents. JMB Papers in Press. 2017: JMB16-11004.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Antibac1 (ID# 7982)
Aptamer chemistry: DNA
Aptamer sequence: TCGCGCGAGTCGTCTGGGGACAGGGAGTGCGCTGCTCCCCCCGCATCGTCCTCCC
Target: Peptidoglycan
Target chemistry: Other
Affinity: 415 nM 
Reference: Ferreira IM, de Souza Lacerda CM, de Faria LS, Corrêa CR, de Andrade AS. Selection of peptidoglycan-specific aptamers for bacterial cells identification. Appl Biochem Biotechnol. 2014 Dec;174(7):2548-56. doi: 10.1007/s12010-014-1206-6. Epub 2014 Sep 4. PMID: 25185503.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: CTBA4T-B1 (ID# 8088)
Aptamer chemistry: DNA
Aptamer sequence: ATCTCGAGTCATAGGGGGCGCGAACATACGCGGTTGGTGTGGTTGGCTGACTCGT
Target: Thrombin
Target chemistry: Peptide
Affinity: 19 pM 
Reference: Mao, Yu et al. “Evolution of a highly functional circular DNA aptamer in serum.” Nucleic acids research vol. 48,19 (2020): 10680-10690. doi:10.1093/nar/gkaa800Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Pyoverdine Aptamer (ID# 8197)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: CCAAAGAGCACUCCAUUCGAUGGUCGUUUUUCGCACAUUCGCUCCGCGAUAGACG
Target: Pyoverdine
Target chemistry: Small Organic
Affinity: 100 nM 
Reference: Anisuzzaman, S., Banerjee, S., Jiang, N., Shrotriya, P., & Nilsen‐Hamilton, M. (2022). Selection and development of aptamers for pyoverdine. The FASEB Journal, 36(S1). https://doi.org/10.1096/fasebj.2022.36.s1.l7887https://www.researchgate.net/profile/Sharif-Anisuzzaman/publication/359769298_Selection_and_development_of_aptamers_for_Pyoverdine/links/624daf76b0cee02d6954821d/Selection-and-development-of-aptamers-for-Pyoverdine.pdfMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: PSMA Aptamer (A10-3) (ID# 7498)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGGACGAUGCGGAUCAGCCAUGUUUACGUCACUCCUUGUCAAUCCUCAUCGGC
Target: PSMA
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Lupold, Shawn, et al. "Identification and Characterization of Nuclease-stabilized RNA Molecules That Bind Human Prostate Cancer Cells via the Prostate-specific  Membrane Antigen." American Association for Cancer Research Journal 62, (2002): 4029-4033Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Pb(II) (ID# 7593)
Aptamer chemistry: DNA
Aptamer sequence: ACTCACTATGGAAGAGATGGCGACATCTCTTCTCCGAGCCGGTCGAAATAGTGAGT
Target: Pb(II)
Target chemistry: Small Organic
Affinity: 4 nM 
Reference: Lu et al. "New highly sensitive and selective catalytic DNA biosensors for metal ions." Biosensors and Bioelectronics, 18(2003): 529-540.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: A10 (ID# 8138)
Aptamer chemistry: DNA
Aptamer sequence: TTGAAGTGACTCCGCACTGGGTGGGTGGGAGGGTCGTGCGGCTGGTCATAGCAGGGT
Target: Bovine pregnancy-associated glycoproteins (bPAGs)
Target chemistry: Protein
Affinity: 11.7 nM 
Reference: Liu, C., Lu, C., & Shi, G. (2020). Selection, identification, and application of DNA aptamers against bovine pregnancy-associated glycoproteins 4. Analytical and Bioanalytical Chemistry. doi:10.1007/s00216-020-02666-wMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Adenosine Triphosphate  (1-1MIN) (ID# 7510)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGAUCUACGGAUCUCAGGGCUCUUACGGGAGCUACAUGGAAGGAGUCCAUGUGU
Target: Adenosine Triphosphate / ATP
Target chemistry: Small Organic
Affinity: 4.8 µM 
Reference: P Sazani, R Larralde, and J Szostak.(2004) "A Small Aptamer with Strong and Specific Recognition of the Triphosphate of ATP." J Am Chem Soc. 126: 8370-8371.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: P-Selectin (PF377) (ID# 7614)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: ACGCUCAACGAGCCAGGAACAUCGACGUCAGCAAACGCGAGCGCAACCAGUAACACC
Target: P-Selectin
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Burnette et al. "RNA Aptamer Therapy for Vaso-Occlusion in Sickle Cell Disease." Nucleic Acids Therapeutics, 21(2011): 275-283.    Jenison et al. "Oligonucleotide Inhibitors of P-Selectin Dependent Neutrophil-Platelet Adhesion." Antisense & Nucleic Acid Development, 8(1998): 265-279.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Dopamine (dopa1.30/c.30) (ID# 7767)
Aptamer chemistry: RNA
Aptamer sequence: GUCUCUGUGUGCGCCAGAGAACACUGGGGCAGAUAUGGGCCAGCACAGAAUGAGGCCC
Target: Dopamine
Target chemistry: Small Organic
Affinity: Not Mentioned in Database
Reference: Mannironi, C., et al. "In Vitro Selection of Dopamine RNA Ligands." Biochemistry, 36 (1997):  9726-9734.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Dopamine (DNA version of dopa1.30/c.30) (ID# 7768)
Aptamer chemistry: DNA
Aptamer sequence: GTCTCTGTGTGCGCCAGAGAACACTGGGGCAGATATGGGCCAGCACAGAATGAGGCCC
Target: Dopamine
Target chemistry: Small Organic
Affinity: 0.7 µM 
Reference: R Walsh and M DeRosa. Retention of function in the DNA homolog of the RNA dopamine aptamer. Biochem. Biophys. Res. Commun. 388(2009): 732-735.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: AMPA GluR2 (AN58) (ID# 7809)
Aptamer chemistry: RNA
Aptamer sequence: GGGCGAAUUCAACUGCCAUCUAGGCAGUAACCAGGAGUUAGUAGGACAAGUUUCGUCC
Target: AMPA GluR2 Glutamate Receptor Channel
Target chemistry: Protein
Affinity: 419 pM 
Reference: Z. Huang et al. RNA aptamers selected against the GluR2 glutamate receptor channel. Biochemistry 46(2007): 12648 - 12655.   Z. Huang et al. One RNA aptamer sequence, two structures: a collaborating pair that inhibits AMPA receptors. Nucleic Acids Res.. 37(2009): 4022 - 4032Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: F5R1 (ID# 8218)
Aptamer chemistry: DNA
Aptamer sequence: ATCGAGTGTGTACGGGGTCCGGTAGGGTGGCGAGGTCTTCCTGTCGTAGCAGGATCCA
Target: alpha-synuclein
Target chemistry: Protein
Affinity: 2.40 nM 
Reference: Yuan Zheng, Jing Qu, Fenqin Xue, Yan Zheng, Bo Yang, Yongchang Chang, Hui Yang, Jianliang Zhang, Novel DNA Aptamers for Parkinson’s Disease Treatment Inhibit α-Synuclein Aggregation and Facilitate its Degradation, Molecular Therapy - Nucleic Acids, Volume 11, 2018, Pages 228-242, ISSN 2162-2531Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Interferon-γ (2’F-1) (ID# 7771)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGGACGAUGCGGACACCGUUAAUCUGAGGCCCUGUCCUAUUCCUUCACGCCUCAGA
Target: Interferon-y/IFN-y/IFNG
Target chemistry: Protein
Affinity: 4.4 nM 
Reference: Kubik, Mark F., et al. "Isolation and Characterization of  2ƒ??-Fluoro-,  2ƒ??-Amino-,  and 2ƒ??-Fluoro-/Amino-Modified  RNA Ligands to  Human  IFN-7 That Inhibit  Receptor  Binding." Journal of Immunology, 159 (1997): 259-267.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: B1-4 (ID# 7903)
Aptamer chemistry: DNA
Aptamer sequence: CCGCCCAAATCCCTAAGAGAAGACTGTAATGACATCAAACCAGACACACTACACACGCA
Target: IFN-Gamma
Target chemistry: Protein
Affinity: 74.5 nM 
Reference: Cao B, Hu Y, Duan J, Ma J, Xu D, et al. (2014) Selection of a Novel DNA Aptamer for Assay of Intracellular Interferon-Gamma. PLoS ONE 9(5): e98214.  doi:10.1371/journal.pone.0098214Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Enterotoxigenic Escherichia coli (E. coli) fimbriae protein K88 (clone 37) (ID# 7924)
Aptamer chemistry: DNA
Aptamer sequence: GAGACCGTACCATCTGTTCGTGGAAGCGCTTTGCTCGTCCATTAGCCTTGTGCTCGTGC
Target: K88
Target chemistry: Protein
Affinity: 25 nM 
Reference: Li, H. et al. Aptamer selection for the detection of Escherichia coli K88. 2011. Canadian Journal of Microbiology 57.6: 453-9.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: ApoE 06 (ID# 7963)
Aptamer chemistry: DNA
Aptamer sequence: GATAAACGCCTTGATTAAAGGCCCAGTTCTTTAGGCCTACACGTGCTGCGACATTAATT
Target: Apolipoprotein E
Target chemistry: Protein
Affinity: 938 pM 
Reference: Wang, J., Gong, Q., Maheshwari, N., Eisenstein, M., Luz Arcila, M., Kosik, K., & Soh, T. Particle Display: A Quantitative Screening Method for Generating High-Affinity Aptamers. Angew. Chem. Int. Ed. 2014, 53, 4796ƒ??4801Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Interferon-Gamma (ID# 7971)
Aptamer chemistry: DNA
Aptamer sequence: CCGCCCAAATCCCTAAGAGAAGACTGTAATGACATCAAACCAGACACACTACACACGCA
Target: Interferon-gamma (IFN-c)
Target chemistry: Protein
Affinity: 74.5 nM 
Reference: Cao, B., Hu, Y., Duan, J., Ma, J., Xu, D., & Yang, X. D. (2014). Selection of a novel DNA aptamer for assay of intracellular interferon-gamma. PloS one, 9(5), e98214.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: BC1 (ID# 8099)
Aptamer chemistry: DNA
Aptamer sequence: ATGACGGGGGTCTAGGCAAGTAATAACGGGGGCAAGCTTTTCTATCTCGTTCTAGGGTA
Target: Osteocalcin (OC)
Target chemistry: Protein
Affinity: 69.34 nM 
Reference: Chinnappan R, Zaghloul NS, AlZabn R, Malkawi A, Abdel Rahman A, Abu-Salah KM, Zourob M. Aptamer selection and aptasensor construction for bone density biomarkers. Talanta. 2021 Mar 1;224:121818. doi: 10.1016/j.talanta.2020.121818. Epub 2020 Oct 29. PMID: 33379043.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: OC10 (ID# 8100)
Aptamer chemistry: DNA
Aptamer sequence: ATGAGTAGTGCGGAGGGATGTGAATACTGACGCGGTCATAGTCGCTGTTGTACCATTGA
Target: beta-crosslap (BC)
Target chemistry: Protein
Affinity: 148.4 nM 
Reference: Chinnappan R, Zaghloul NS, AlZabn R, Malkawi A, Abdel Rahman A, Abu-Salah KM, Zourob M. Aptamer selection and aptasensor construction for bone density biomarkers. Talanta. 2021 Mar 1;224:121818. doi: 10.1016/j.talanta.2020.121818. Epub 2020 Oct 29. PMID: 33379043.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: SP3 (ID# 8112)
Aptamer chemistry: DNA
Aptamer sequence: AAGGATGACTGACGACGATGGGAATGGAGAGGAAGGGGATATAGGTATGTTGGATGTAG
Target: Sepiapterin reductase deficiency (SR)
Target chemistry: Other
Affinity: 37.3 nM 
Reference: Eissa S, Alkhaldi S, Chinnappan R, Siddiqua A, Abduljabbar M, Abdel Rahman AM, Dasouki M, Zourob M. Selection, characterization, and electrochemical biosensing application of DNA aptamers for sepiapterin. Talanta. 2020 Aug 15;216:120951. doi: 10.1016/j.talanta.2020.120951. Epub 2020 Mar 20. PMID: 32456943.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: YFL-4 (ID# 8179)
Aptamer chemistry: DNA
Aptamer sequence: GCAGGACACCGTAACACGGGCTGATGCTCTCTTTATTTTACCTAAATAAAGTGTCCTGC
Target: Lactoferrin
Target chemistry: Protein
Affinity: 0.953 nM 
Reference: Yu, F., Li, H., Sun, W., Xu, D. and He, F., 2019. Rapid selection of aptamers based on protein microarray. RSC advances, 9(17), pp.9762-9768.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HD1-60.29-15dA (ID# 8223)
Aptamer chemistry: DNA
Aptamer sequence: GGTTGGTGTGGTTGGAAAAAAAAAAAAAAAAGTCCGTGGTAGGGCAGGTTGGGGTGACT
Target: Thrombin
Target chemistry: Protein
Affinity: 4.9 nM 
Reference: Müller J, Wulffen B, Pötzsch B, Mayer G. Multidomain targeting generates a high-affinity thrombin-inhibiting bivalent aptamer. Chembiochem. 2007 Dec 17;8(18):2223-6. doi: 10.1002/cbic.200700535. PMID: 17990265.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Gonadotropin-releasing hormone 1 (60-mer S42) (ID# 7493)
Aptamer chemistry: L-DNA
Aptamer sequence: GCGGCGGAGGGTGGGCTGGGGCTGGGCCGGGGGGCGTGCGTAAGCACGTAGCCTCGCCGC
Target: Gonadoliberin/Gonadotropin-releasing hormone 1 (GnRH)
Target chemistry: Peptide
Affinity: 45 nM 
Reference: Leva, S., et al. "GnRH Binding RNA and DNA Spiegelmers: A Novel Approach toward GnRH Antagonism." Chemistry and Biology, 9 (2002): 351-359.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Tetracycline (cb28 minimer) (ID# 7522)
Aptamer chemistry: RNA
Aptamer sequence: GGCCUAAAACAUACCAGAUUUCGAUCUGGAGAGGUGAAGAAUUCGACCACCUAGGCCGGU
Target: Tetracycline
Target chemistry: Small Organic
Affinity: ~1 µM 
Reference: Berens C, Thain, A, Schroeder R. (2001) A tetracycline-binding RNA aptamer. Bioorg Med Chem. 9:2549-2556.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Bacillus thuringiensis spores (ID# 7756)
Aptamer chemistry: DNA
Aptamer sequence: CATCCGTCACACCTGCTCTGGCCACTAACATGGGGACCAGGTGGTGTTGGCTCCCGTATC
Target: Bacillus thuringiensis spores
Target chemistry: Cells
Affinity: Not Mentioned in Database
Reference: M Ikanovic et al. Fluorescence assay based on aptamer-quantum dot binding to Bacillus thuringiensis spores. J Fluoresc 17(2007): 193-199Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Microcystin (RC6) (ID# 7827)
Aptamer chemistry: DNA
Aptamer sequence: CACGCAACAACACAACATGCCCAGCGCCTGGAACATATCCTATGAGTTAGTCCGCCCACA
Target: Microcystin
Target chemistry: Small Organic
Affinity: 28-61 nM 
Reference: Ng A, Zourob M, et al. (2012) Selection, characterization and biosensing application of high affinity congener-specific microcystin-targeting aptamers. Environ. Sci. Technol. 46: 10697-10703.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Microcystin-LR (AN6) (ID# 7828)
Aptamer chemistry: DNA
Aptamer sequence: GGCGCCAAACAGGACCACCATGACAATTACCCATACCACCTCATTATGCCCCATCTCCGC
Target: Microcystin-LR
Target chemistry: Small Organic
Affinity: 50 nM 
Reference: Ng A, Zourob M, et al. (2012) Selection, characterization and biosensing application of high affinity congener-specific microcystin-targeting aptamers. Environ. Sci. Technol. 46: 10697-10703.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: VEGF (3R02 bivalent) (ID# 7857)
Aptamer chemistry: DNA
Aptamer sequence: TGTGGGGGTGGACTGGGTGGGTACCTTTTTTTTTTTGTGGGGGTGGACTGGGTGGGTACC
Target: Vascular Endothelial Growth Factor (VEGF)
Target chemistry: Protein
Affinity: 30 pM 
Reference: Nonaka, Y. "Affinity Improvement of a VEGF Aptamer by in Silico Maturation for a Sensitive VEGF-Detection System." Anal. Chem., 85 (2013): 1132-1137.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Fcγ receptor IIIα / CD16α (CLN0020) (ID# 7859)
Aptamer chemistry: DNA
Aptamer sequence: GGAGGGAAAAGTTATCAGGCCACTGCGGGGGTCTATACGTGAGGAAGAAGTGGGCAGGTC
Target: FcγrIIIα / FcgrIIIa / CD16a
Target chemistry: Protein
Affinity: 22 nM 
Reference: Boltz A, Plater B, Hock B, et al. (2011) Bi-specific Aptamers Mediating Tumour Cell Lysis. J Biol Chem 286: 21896-21905Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Okadaic Acid Aptamer (OA-34) (ID# 7877)
Aptamer chemistry: DNA
Aptamer sequence: GGTCACCAACAACAGGGAGCGCTACGCGAAGGGTCAATGTGACGTCATGCGGATGTGTGG
Target: Okadaic acid
Target chemistry: Small Organic
Affinity: 77 nM 
Reference: Eissa, S., Ng, A., Siaj, M., Tavares, A., and Zourob, M. "Selection and Identification of DNA Aptamers against Okadaic Acid for Biosensing Application." Analytical Chemistry 85.24 (2013): 11794-801.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Botulinum neurotoxin type A (BoNT A) Aptamer (ID# 7952)
Aptamer chemistry: DNA
Aptamer sequence: CTTGAGTGTCATGGACGTTCCGGTCTTGGGCGGGATATTTGTTTGTTTTCTGCCTATGTT
Target: BoNT A Light Chain (BoNT/A-rLc)
Target chemistry: Protein
Affinity: 34 nM 
Reference: (1) Bogomolova, A., Aldissi, M. ƒ??Real-time and label-free analyte detection in a flow-through mode using immobilized fluorescent aptamer/quantum dots molecular switches.ƒ? Biosensors and Bioelecgtronics, 66 (2015): 290-296. (2) Lou, X., et al. ƒ??Micromagnetic selection of aptamers in microfluidic channels.ƒ? PNAS, 106, 9 (2009): 2989-2994.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Thrombin 03 (ID# 7962)
Aptamer chemistry: DNA
Aptamer sequence: CAGCGCTAGGGCTTTTAGCGTAATGGGTAGGGTGGTGCGGTGCAGATATCGGAATTGGTG
Target: Thrombin
Target chemistry: Protein
Affinity: 7.03 pM 
Reference: Wang, J., Gong, Q., Maheshwari, N., Eisenstein, M., Luz Arcila, M., Kosik, K., & Soh, T. Particle Display: A Quantitative Screening Method for Generating High-Affinity Aptamers. Angew. Chem. Int. Ed. 2014, 53, 4796ƒ??4801Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: PAI-1 01 (ID# 7964)
Aptamer chemistry: DNA
Aptamer sequence: CATTGAGATAGCTAGTTGTAGCTGCGTCATAGGCTGGGTTGGGTCTAGTGGTTGGGTGTG
Target: Plasminogen Activator Inhibitor-1
Target chemistry: Protein
Affinity: 339 pM 
Reference: Wang, J., Gong, Q., Maheshwari, N., Eisenstein, M., Luz Arcila, M., Kosik, K., & Soh, T. Particle Display: A Quantitative Screening Method for Generating High-Affinity Aptamers. Angew. Chem. Int. Ed. 2014, 53, 4796ƒ??4801Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: 4-1BB 07 (ID# 7965)
Aptamer chemistry: DNA
Aptamer sequence: GTCAGATTCCACTATAGTAGGTTGGGTAGGGTGGTCGCAGTGGATGATATGTCGTAGGGG
Target: 4-1BB Ligand
Target chemistry: Protein
Affinity: 2.32 nM 
Reference: Wang, J., Gong, Q., Maheshwari, N., Eisenstein, M., Luz Arcila, M., Kosik, K., & Soh, T. Particle Display: A Quantitative Screening Method for Generating High-Affinity Aptamers. Angew. Chem. Int. Ed. 2014, 53, 4796ƒ??4801Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Spinach (ID# 8022)
Aptamer chemistry: RNA
Aptamer sequence: GGGCUAUUGCUGGAGGGGCGCCACAUGAAAGUGGUGGUUGGGUGCGGUCGGCGAUAGCUC
Target: 3,5-dimethoxy-4-hydroxybenzylidene imidazolinone (DHMBI)
Target chemistry: Small Organic
Affinity: 512 nM 
Reference: Paige, J. S., Wu, K. Y., & Jaffrey, S. R. (2011). RNA Mimics of Green Fluorescent Protein. Science, 333(6042), 642–646. doi:10.1126/science.1207339Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: s5rev (ID# 8035)
Aptamer chemistry: DNA
Aptamer sequence: CATGCTTCCCCAGGGAGATGACCGGGGCGTACACCGTCGCGGCACATGTCTGAATGCGTTTAGTCTCTGTGG
Target: CD44
Target chemistry: Protein
Affinity: 238 nM 
Reference: Pęcak, Aleksandra, et al. “Anti-CD44 DNA Aptamers Selectively Target Cancer Cells.” Nucleic Acid Therapeutics, vol. 30, no. 5, 2020, pp. 289–298., doi:10.1089/nat.2019.0833.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Anti-HSA Structure-switching Aptamer (ID# 8060)
Aptamer chemistry: DNA
Aptamer sequence: CGTACCGGCCAGTGATTACGACGAGACGAGCTTATGCGTATTGATGCCTAACTATCTACA
Target: HSA (Human Serum Albumin)
Target chemistry: Protein
Affinity: 20 ± 4 nM 
Reference: Qiao, N., Li, J., Wu, X., Diao, D., Zhao, J., Li, J., … Lou, X. (2019). Speeding up in vitro Discovery of Structure-Switching Aptamers via Magnetic Cross-Linking Precipitation. Analytical Chemistry. doi:10.1021/acs.analchem.9b00081Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: S6-1 (ID# 8061)
Aptamer chemistry: DNA
Aptamer sequence: TCAAGTCACAGGTTCCAGGTAATACCTAAGGGTATGCTCTCGCCTATTATATGGAGCACG
Target: human malignant glioma cell line SHG44
Target chemistry: Cells
Affinity: 44 ± 15 nM 
Reference: Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: R10C1 (ID# 8121)
Aptamer chemistry: DNA
Aptamer sequence: GCAATGGTACGGTACTTCCCCACCCCACGCTGCTCCCAAAAGTGCACGCTACTTTGCTAA
Target: Legionella pneumophila (Lp)
Target chemistry: Other
Affinity: 135 nM 
Reference: Saad, M.; Chinerman, D.; Tabrizian, M.; Faucher, S. Identification of two aptamers binding to Legionella pneumophila with high affinity and specificity. Sci Rep. 2020 Jun 4; 10: 9145. doi: 10.1038/s4598-020-65973-3. PMCID: PMC7272621. PMID: 32499557.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HBA1 (ID# 8130)
Aptamer chemistry: DNA
Aptamer sequence: ATGCGGATCCCGCGCGCGACCGTGTCAGCGGGGACTAGCGGTGTAGCGCGAAGCTTGCGC
Target: Avian Influenza Virus Subtype H5N1
Target chemistry: Other
Affinity: 70 nM 
Reference: Kim, S.; Choi, J.; Kim, A.; Lee, S.; Yoon, M. Development of ssDNA Aptamers for Diagnosis and Inhibition of the Highly Pathogenic Avian Influenza Virus Subtype H5N1. Biomolecules 2020 July 28; 10(8): 1116. DOI: 10.3390/biom10081116.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HBA2 (ID# 8131)
Aptamer chemistry: DNA
Aptamer sequence: ATGCGGATCCCGCGCGGGTCTGAGGAGTGCGCGGTGCCAGTGAGTGCGCGAAGCTTGCGC
Target: Avian Influenza Virus Subtype H5N1
Target chemistry: Other
Affinity: 122 nM 
Reference: Kim, S.; Choi, J.; Kim, A.; Lee, S.; Yoon, M. Development of ssDNA Aptamers for Diagnosis and Inhibition of the Highly Pathogenic Avian Influenza Virus Subtype H5N1. Biomolecules 2020 July 28; 10(8): 1116. DOI: 10.3390/biom10081116.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.