rpgv/AptaCom huggingface dataset:
Aptamer: N5 (ID# 8080)
Aptamer chemistry: DNA
Aptamer sequence: GATTGAGTAGATAGTGGTTCTGTACGTAGTGAAAGAGTGG
Target: PD-L1
Target chemistry: Protein
Affinity: 441 nM 
Reference: Li, X., Li, Z., & Yu, H. (2020). Selection of threose nucleic acid aptamers to block PD-1/PD-L1 interaction for cancer immunotherapy. Chemical Communications. doi:10.1039/d0cc06032aMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: T-2 (ID# 8098)
Aptamer chemistry: DNA
Aptamer sequence: CGCGTGAGCGGGGAGGCGATGCCCAGGCTAACTTGACTCA
Target: thyroglobulin
Target chemistry: Protein
Affinity: 3.18 nM 
Reference: Zhu, C., Li, L., Fang, S., Zhao, Y., Zhao, L., Yang, G., & Qu, F. (2020). Selection and Characterization of an ssDNA Aptamer against Thyroglobulin. Talanta, 121690. doi:10.1016/j.talanta.2020.121690Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: RhD antigen‑specificity 1 (ID# 8105)
Aptamer chemistry: DNA
Aptamer sequence: GGCCTGGTCTGTTAGCCGGGTAGCAGCCCCGGCACCTATT
Target: RhD+ red blood cells
Target chemistry: Cells
Affinity: 580.5±142.0 nM 
Reference: Zhang Y, Xu H, Wang X, Wang L, Liu R, Li L, Zhou H. Single‑strained DNA aptamers mask RhD antigenic epitopes on human RhD+ red blood cells to escape alloanti‑RhD immunological recognition. Mol Med Rep. 2020 Apr;21(4):1841-1848. doi: 10.3892/mmr.2020.10985. Epub 2020 Feb 12. PMID: 32319623; PMCID: PMC7057830.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: RhD antigen‑specificity 2 (ID# 8106)
Aptamer chemistry: DNA
Aptamer sequence: GGGTAGCAGCCCCGCGGAGGGTCGGCTATAAGAACCAAGA
Target: RhD+ red blood cells
Target chemistry: Cells
Affinity: 737.7±161.8 nM 
Reference: 'Zhang Y, Xu H, Wang X, Wang L, Liu R, Li L, Zhou H. Single‑strained DNA aptamers mask RhD antigenic epitopes on human RhD+ red blood cells to escape alloanti‑RhD immunological recognition. Mol Med Rep. 2020 Apr;21(4):1841-1848. doi: 10.3892/mmr.2020.10985. Epub 2020 Feb 12. PMID: 32319623; PMCID: PMC7057830.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HPA-2 (ID# 8107)
Aptamer chemistry: DNA
Aptamer sequence: CCAGGAGGACCCTATTCTCGTGTATCGACGAGATCCAGTG
Target: Helicobacter pylori
Target chemistry: Other
Affinity: 19.3 ± 3.2 nM 
Reference: Wu, Hangjie et al. “Rapid Detection of Helicobacter pylori by the Naked Eye Using DNA Aptamers.” ACS omega vol. 6,5 3771-3779. 21 Jan. 2021, doi:10.1021/acsomega.0c05374Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: f-4 (ID# 8155)
Aptamer chemistry: DNA
Aptamer sequence: CGCCAAAGCTCGATCAATAACCGAAAGAAAAGGCACATCA
Target: fetuin
Target chemistry: Other
Affinity: 6.2 µM 
Reference: Discovery of indole-modified aptamers for highly specific recognition of protein glycoformsAlex M. Yoshikawa, Alexandra Rangel, Trevor Feagin, Elizabeth M. Chun, Leighton Wan, Anping Li, Leonhard Moekl, Michael Eisenstein, Sharon Pitteri, H. Tom SohbioRxiv 2021.03.13.435263; doi: https://doi.org/10.1101/2021.03.13.435263Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Sp1 (ID# 8168)
Aptamer chemistry: DNA
Aptamer sequence: TTCTTCCCTTTTATTAGTCCTGTATTCCTCTACTGTTGCC
Target: Shigella sonnei
Target chemistry: Cells
Affinity: 5.980 nM 
Reference: Gong, Wenhui, et al. “Selection, Identification, and Application of Dual DNA Aptamers against Shigella Sonnei.” Analytical Methods, vol. 7, no. 8, 2015, pp. 3625–3631., https://doi.org/10.1039/c5ay00214a.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: PSA-1 (ID# 8202)
Aptamer chemistry: DNA
Aptamer sequence: GGACGGTTGCGCTATATTTAACCAAAAGTCTGGATTAACA
Target: PSA (glycosylated)
Target chemistry: Protein
Affinity: 177 +/-65 nM 
Reference: Diaz-Fernandez, A, et al. "Focusing aptamer selection on the glycan structure of prostate-specific antigen: Toward a more specific detection of prostate cancer." Biosensors and Bioelectronics, 128 (2019): 83-90. doi: https://doi.org/10.1016/j.bios.2018.12.040Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: 4520-8 (ID# 8211)
Aptamer chemistry: DNA
Aptamer sequence: TCGGCTTCGGGTACCTATTATCGGTTTAGCCCAGTCAGAA
Target: Staphylococcal protein A
Target chemistry: Protein
Affinity: 0.22 nM 
Reference: Baumstummler, A., Lehmann, D., Janjic, N., Ochsner, U.A., 2014. Specific capture and detection of staphylococcus aureus with high-affinity modified aptamers to cell surface components. Lett. Appl. Microbiol. 59, 422–431.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: D1 (ID# 8214)
Aptamer chemistry: DNA
Aptamer sequence: GGTTGACGGCAGTCGGCGGTATGCGCATATCGTGTTGGTA
Target: Human Collagen XIα1 (C-telopeptide region)
Target chemistry: Peptide
Affinity: 23 +/- 5 nM 
Reference: Lorenzo-Gomez, R, et al. Aptamers targeting a tumor-associated extracellular matrixcomponent: The human mature collagen XIa1. Analytica Chimica Acta, 1189 (2022): 339206. doi: https://doi.org/10.1016/j.aca.2021.339206Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: BI1 (ID# 8220)
Aptamer chemistry: DNA
Aptamer sequence: AGCGATACTGCGTGGCTGGAGGCGGGTAGGGCCAGAGTTC
Target: BACE1
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Jun Xiang, Wen Zhang, Xiao-Fang Cai, Min Cai, Zhong-Hai Yu, Feng Yang, Wen Zhu, Xiang-Ting Li, Ting Wu, Jing-Si Zhang, Ding-Fang Cai, DNA Aptamers Targeting BACE1 Reduce Amyloid Levels and Rescue Neuronal Deficiency in Cultured Cells, Molecular Therapy - Nucleic Acids, Volume 16, 2019, Pages 302-312, ISSN 2162-2531.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Ancrod-55 (ID# 8224)
Aptamer chemistry: DNA
Aptamer sequence: GGACCGACCCTTTAGCATTTATGACCCTTGTCATCGGGCT
Target: ancrod
Target chemistry: Protein
Affinity: 3.0 nM 
Reference: Alomran, N, Raja, C, Alsolaiss, J, Casewell, NR, Zourob, M. (2022) Exploring the utility of ssDNA aptamers directed against snake venom toxins as new therapeutics for snakebite envenoming. Toxins, 14, 469. https://doi.org/10.3390/toxins14070469.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Batroxobin-26 (ID# 8225)
Aptamer chemistry: DNA
Aptamer sequence: TGTCTGGTATGCAAAGGACTGCTGTACTGTTAGCTTTTG
Target: batroxobin
Target chemistry: Protein
Affinity: 4.7 nM 
Reference: Alomran, N, Raja, C, Alsolaiss, J, Casewell, NR, Zourob, M. (2022) Exploring the utility of ssDNA aptamers directed against snake venom toxins as new therapeutics for snakebite envenoming. Toxins, 14, 469. https://doi.org/10.3390/toxins14070469.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Cytochrome c (ID# 8227)
Aptamer chemistry: DNA
Aptamer sequence: CCGTGTCTGGGGCCGACCGGCGCATTGGGTACGTTGTTGC
Target: Cytochrome c
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: https://patents.google.com/patent/CN108801989B/enMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Aptamer 3-83 (ID# 8246)
Aptamer chemistry: DNA
Aptamer sequence: AGGGCTATGAGCCCTGCGCCGACGTCAGGCGCACCGAGAC
Target: Uridine 5' diphosphate
Target chemistry: Other
Affinity: 274.8 µM 
Reference: Guo, S., Lin, J., Lin, L. et al. Selecting small molecule DNA aptamers with significant conformational changes for constructing transcriptional switches and biosensors. Sci. China Chem. 66, 1529–1536 (2023). https://doi.org/10.1007/s11426-022-1540-yMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Cellobiose (Cel#16) (ID# 7497)
Aptamer chemistry: DNA
Aptamer sequence: GCGGGGTTGGGCGGGTGGGTTCGCTGGGCAGGGGGCGAGTG
Target: Cellobiose
Target chemistry: Small Organic
Affinity: 600 nM 
Reference: Yang, Q., et al. "DNA ligands that bind tightly and selectively to cellobiose." PNAS, 95 (1998): 5462-5467.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Daunomycin (10.10v) (ID# 7558)
Aptamer chemistry: DNA
Aptamer sequence: ACCATCTGTGTAAGGGGTAAGGGGTGGGGGTGGGTACGTCT
Target: Daunomycin
Target chemistry: Small Organic
Affinity: 272 nM 
Reference: Wochner, et al. "A DNA aptamer with high affinity and specificity for therapeutic anthracyclines." Analytical Biochemistry, 373(2008): 34-42.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Pepocin (9-41U22) (ID# 7572)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGUCUGAAGUCGGACUUGUUAUCAAUUCACUUCAGACU
Target: Pepocin
Target chemistry: Protein
Affinity: 18 nM 
Reference: Hirao et al. "RNA Aptamers That Bind to and Inhibit the Ribosome-inactivating Protein, Pepocin." The Journal of Biological Chemistry, 275(2000): 4943-4948.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HIV-1 Reverse Transcriptase (R1T) (ID# 7782)
Aptamer chemistry: DNA
Aptamer sequence: CGCCTGATTAGCGATACTCAGGCGTTGGGTGGGTGGGTGGG
Target: HIV-1 RT
Target chemistry: Protein
Affinity: 1.1 nM 
Reference: D Michalowski et al. Novel bimodular DNA aptamers with guanosine  quadruplexes inhibit phylogenetically diverse HIV-1 reverse transcriptases. Nucleic Acid Res. 36(2008): 7124-7135.   Y-T Lai and J DeStefano. DNA aptamers to human immunodeficiency virus reverse transcriptase selected by a primer-free SELEX method: characterization and comparison with other aptamers. Nucleic Acid Therapeutics 22(2012): 162-176.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: CCRF-CEM (sgc8c) (ID# 7813)
Aptamer chemistry: DNA
Aptamer sequence: ATCTAACTGCTGCGCCGCCGGGAAAATACTGTACGGTTAGA
Target: Acute lymphoblastic leukemia (CCRF-CEM)
Target chemistry: Cells
Affinity: 0.78 nM 
Reference: Sequence:   Shangguan et al. "Optimization and Modifications of Aptamers Selected from Live Cancer Cell Lines." Chem. Biochem., 8, (2007): 603-6.    Doxorubicin conjugation:   Y-F Huang et al. Molecular assembly of an aptamer-drug conjugate for targeted drug delivery to tumor cells. Chembiochem. 10(2009):862-868.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Anti Lung Carcinoma ( EJ4) (ID# 7871)
Aptamer chemistry: DNA
Aptamer sequence: GAAGACGAGCGGCGAGTGTTATTACGCTTGGAAACAACCCC
Target: Lung Adenocarcinoma (H23)
Target chemistry: Cells
Affinity: 60 nM 
Reference: Jimenez et al. Generation of Lung Adenocarcinoma DNA Aptamers for  Cancer Studies (PLOSone)Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: DTA-64 (ID# 7978)
Aptamer chemistry: DNA
Aptamer sequence: GGGGTTAAATATTCCCACATTGCCTGCGCCAGTACAAATAG
Target: DEK
Target chemistry: Protein
Affinity: N/A µM 
Reference: N Mor-Vaknin et al. DEK-targeting DNA aptamers as therapeutics  for inflammatory arthritis. Nature Communications 8(2017): 14252.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: WT62 (ID# 8071)
Aptamer chemistry: DNA
Aptamer sequence: TCGGTTGAGTGAGATTAGTCAAATGTTTAGAAGACAACCTC
Target: HIV-1 Reverse Transcriptase
Target chemistry: Protein
Affinity: 7.51±0.29x10^-8 nM 
Reference: Hannongbua, S., Ratanabunyong, S., Aeksiri, N., Yanaka, S., Yagi-Utsumi, M., Kato, K., & Choowongkomol, K. (2020). Characterization of new DNA Aptamers for anti‐HIV‐1 Reverse Transcriptase. ChemBioChem. doi:10.1002/cbic.202000633Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: CBSA-5335 LF (ID# 8119)
Aptamer chemistry: DNA
Aptamer sequence: CTCCTTCAACGAAGTGGGTCTCCTTCAACGAAGTGGGTCTC
Target: Cocaine
Target chemistry: Small Organic
Affinity: 36 nM 
Reference: Yu, H., Canoura, J., Guntupalli, B., Lou, X., & Xiao, Y. (2017). A cooperative-binding split aptamer assay for rapid, specific and ultra-sensitive fluorescence detection of cocaine in saliva. Chemical Science, 8(1), 131–141. doi:10.1039/c6sc01833eMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Apt22 (ID# 8212)
Aptamer chemistry: DNA
Aptamer sequence: ATGGACGAATATCGTCTCCCAGTGAATTCAGTCGGACAGCG
Target: Salmonella Paratyphi A
Target chemistry: Cells
Affinity: 47 nM 
Reference: Yang, M., Peng, Z., Ning, Y., Chen, Y., Zhou, Q., Deng, L., 2013. Highly specific and cost-efficient detection of salmonella paratyphi a combining aptamers with single-walled carbon nanotubes. Sensors 13, 6865–6881.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: S-adenosyl homocysteine (CTH-5) (ID# 7514)
Aptamer chemistry: RNA
Aptamer sequence: GGGCGGAUGAGACGCUUGGCGUGUGCUGUGGAGAGUCAUCCG
Target: S-adenosyl homocysteine
Target chemistry: Small Organic
Affinity: 0.1 nM 
Reference: Gebhardt, K., et al. "RNA Aptamers to S-Adenosylhomocysteine: Kinetic Properties, Divalent Cation  Dependency, and Comparison with Anti-S-adenosylhomocysteine Antibody." Biochemistry, 39 (2000): 7255-7265.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HMBA (aptabeacon) (ID# 7716)
Aptamer chemistry: DNA
Aptamer sequence: ACAGGTTGGTCTGGTTGGGTTTGGCTCCTGTGTACGCAACCTGCG
Target: 6X His-tag
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: X Tan et al. Molecular beacon aptamers for direct and universal quantitation of recombinant proteins from cell lysates. Anal. Chem. [published online ahead of print August 23, 2012]. doi: 10.1021/ac301764qMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Mouse Lipocalin-2 (mLcn2) (Oligo 569) (ID# 7744)
Aptamer chemistry: RNA
Aptamer sequence: CCUCCGGCUCAUACCUUUUCGAAGACAAGCUUCGACAGGAGG
Target: Mouse Lipocalin-2 (mLcn2)
Target chemistry: Protein
Affinity: 340 nM 
Reference: L. Zhat et al. An RNA aptamer-based microcantilever sensor to detect the inflammatory marker, mouse lipocalin-2. Anal. Chem. 84(2012):8763-8770.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Salmonella Typhimurium OmpC Protein (T-2) (ID# 7876)
Aptamer chemistry: RNA
Aptamer sequence: UAGUGUGAGAGCCGUGAGUGAAAGGCCGCGACAAAGAUCGGA
Target: S. Typhimurium OmpC Protein
Target chemistry: Protein
Affinity: 20 nM 
Reference: Han, S. R. and Lee, S. "In Vitro Selection of RNA Aptamer Specific to Salmonella Typhimurium." Journal of Microbiology and Biotechnology, 23.6(2013): 878-84.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: XA-A9 (ID# 8093)
Aptamer chemistry: DNA
Aptamer sequence: TTGCCCACAGATCTGTGGAAGCCGAACCGCGTGCTAGTCGTG
Target: Thy-1 membrane glycoprotein
Target chemistry: Protein
Affinity: 15 nM 
Reference: Wang H, Li X, Lai LA, Brentnall TA, Dawson DW, Kelly KA, Chen R, Pan S. X-aptamers targeting Thy-1 membrane glycoprotein in pancreatic ductal adenocarcinoma. Biochimie. 2021 Feb;181:25-33. doi: 10.1016/j.biochi.2020.11.018. Epub 2020 Nov 23. PMID: 33242496; PMCID: PMC7863625.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: XA-B216 (ID# 8094)
Aptamer chemistry: DNA
Aptamer sequence: TTGCCCACCTCCCTGTGCGGGCCACAGAGCAGCAGTGTCGTG
Target: Thy-1 membrane glycoprotein
Target chemistry: Protein
Affinity: 36 nM 
Reference: Wang H, Li X, Lai LA, Brentnall TA, Dawson DW, Kelly KA, Chen R, Pan S. X-aptamers targeting Thy-1 membrane glycoprotein in pancreatic ductal adenocarcinoma. Biochimie. 2021 Feb;181:25-33. doi: 10.1016/j.biochi.2020.11.018. Epub 2020 Nov 23. PMID: 33242496; PMCID: PMC7863625.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: XA-B217 (ID# 8095)
Aptamer chemistry: DNA
Aptamer sequence: TTGCCCACCGTACTGTGCAGGTCGAACTACAGGCACGTCGTG
Target: Thy-1 membrane glycoprotein
Target chemistry: Protein
Affinity: 2 nM 
Reference: Wang H, Li X, Lai LA, Brentnall TA, Dawson DW, Kelly KA, Chen R, Pan S. X-aptamers targeting Thy-1 membrane glycoprotein in pancreatic ductal adenocarcinoma. Biochimie. 2021 Feb;181:25-33. doi: 10.1016/j.biochi.2020.11.018. Epub 2020 Nov 23. PMID: 33242496; PMCID: PMC7863625.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: CD63-1 (ID# 8097)
Aptamer chemistry: DNA
Aptamer sequence: TAACACGACAGACGTTCGGAGGTCGAACCCTGACAGCGTGGG
Target: CD63
Target chemistry: Protein
Affinity: 38.71 nM 
Reference: Song Z, Mao J, Barrero RA, Wang P, Zhang F, Wang T. Development of a CD63 Aptamer for Efficient Cancer Immunochemistry and Immunoaffinity-Based Exosome Isolation. Molecules. 2020 Nov 27;25(23):5585. doi: 10.3390/molecules25235585. PMID: 33261145; PMCID: PMC7730289.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: CSS.1 (ID# 8201)
Aptamer chemistry: DNA
Aptamer sequence: GACGACGCCCGCATGTTCCATGGATAGTCTTGACTAGTCGTC
Target: Cortisol
Target chemistry: Small Organic
Affinity: 245 nM 
Reference: Niu, C., Ding, Y., Zhang, C., & Liu, J. (2022). Comparing two cortisol aptamers for label-free fluorescent and colorimetric biosensors. Sensors & Diagnostics, 1(3), 541–549. https://doi.org/10.1039/d2sd00042cMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Avian Myeloblastosis Virus (a.1.1) (ID# 7574)
Aptamer chemistry: RNA
Aptamer sequence: CGUCCCGUGCGCAAAAGUUCUUAGCGCUAGCAGUCCUAGUUGC
Target: Avian Myeloblastosis Virus (AMV) RT
Target chemistry: Protein
Affinity: 0.5 nM 
Reference: Chen and Gold. "Selection of High-Affinity RNA Ligands to Reverse Transcriptase: Inhibition of  cDNA Synthesis and RNase H Activity." Journal of Biochemistry, 33(1994): 8746-8756.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: GE54 (ID# 7909)
Aptamer chemistry: DNA
Aptamer sequence: TATTTTTATATTTGTTTGACAGTCGCTTGCTTGTGTAGGCGTT
Target: Rabies Virus glycoprotein(RABV)
Target chemistry: Protein
Affinity: 307 nM 
Reference: Hong-Ru Liang, Gui-Qiu Hu, Xiang-Hong Xue, Lu Li, Xue-Xing Zheng,Yu-Wei Gao, Song-Tao Yang, Xian-Zhu Xia, "Selection of an aptamer against rabies virus: A new class of molecules with antiviral activity". Virus Research 184 (2014) 7-13.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Cocaine Aptamer (ID# 7966)
Aptamer chemistry: DNA
Aptamer sequence: GACAAGGATAAATCCTTCAATGAAGTGGGTCACTCATCTGTGA
Target: Cocaine
Target chemistry: Small Organic
Affinity: Not Mentioned in Database
Reference: Yang, Z. et al. Community Sewage Sensors towards Evaluation of Drug Use Trends: Detection of Cocaine in Wastewater with DNA-Directed Immobilization Aptamer Sensors. Sci. Rep. 6, 21024; doi: 10.1038/srep21024 (2016).Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: LZH5B (ID# 8024)
Aptamer chemistry: DNA
Aptamer sequence: GTGACGCAGCAGCTACTTGGGCCCTGGTTTCTGTGCTGGACAC
Target: HepG2 Liver Cancer Cells
Target chemistry: Cells
Affinity: 12 nM 
Reference: Zhang, L., Wang, S., Yang, Z., Hoshika, S., Xie, S., Li, J., …Tan, W. (2019). An Aptamer‐Nanotrain Assembled from 6‐Letter DNA Delivers Doxorubicin Selectively to Liver Cancer Cells. Angewandte Chemie. doi:10.1002/ange.201909691Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Aptamer A14 (ID# 8033)
Aptamer chemistry: DNA
Aptamer sequence: CCTGCCTTTGGCAGCCGGGCGAAGGCAACCCGACACCGACAGC
Target: HA protein of CJ01 H1N1 Influenza Virus
Target chemistry: Protein
Affinity: 2.98 nM 
Reference: Kwon, J., Narayan, C., Kim, C., Han, M. J., Kim, M., & Jang, S. K. (2019). Development of a Subtype-Specific Diagnostic System for Influenza Virus H3N2 Using a Novel Virus-Based Systematic Evolution of Ligands by Exponential Enrichment (Viro-SELEX). Journal of Biomedical Nanotechnology, 15(7), 1609–1621. https://doi.org/10.1166/jbn.2019.2789Gold L, Ayers D, Bertino J, Bock C, Bock A, Brody EN, et al. (2010) Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery. PLoS ONE 5(12): e15004. https://doi.org/10.1371/journal.pone.0015004Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: L-Citrulline (44Cit11) (ID# 7517)
Aptamer chemistry: RNA
Aptamer sequence: GACGAGAAGGAGUGCUGGUUAUACUAGCGGUUAGGUCACUCGUC
Target: L-Citrulline
Target chemistry: Small Organic
Affinity: 68 µM 
Reference: Famulok, M., "  Molecular Recognition of Amino Acids by RNA-Aptamers: An L-Citrulline Binding RNA Motif and its Evolution into an L-Arginine Binder." Journal of the American Chemical Society, 116 (1994): 1698-1706.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: C-Reactive Protein Monomer (ID# 7565)
Aptamer chemistry: RNA
Aptamer sequence: GCCUGUAAGGUGGUCGGUGUGGCGAGUGUGUUAGGAGAGAUUGC
Target: Monomeric C-Reactive Protein (CRP)
Target chemistry: Protein
Affinity: 187.7 nM 
Reference: M S Wang et al. "C-reactive protein (CRP) aptamer binds to monomeric  but not pentameric form of CRP." Analytical and Bioanalytical Chemistry, 401(2011): 1309-1318.    M S Wang and S M Reed. Direct visualization of electrophoretic mobility shift assays using nanoparticle-aptamer conjugates. Electrophoresis. 33(2012): 348-351.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.