rpgv/AptaCom huggingface dataset:
Aptamer: Anti-VEGF165 Unnatural Base DNA Aptamer #4 (ID# 7985)
Aptamer chemistry: Chimeric
Aptamer sequence: GCGGTAAACTGCGTCCGAAGGGGCTGCAGTGACCCGAATGGGTCCGCCGCGAAGCG
Target: VEGF165
Target chemistry: Protein
Affinity: 0.9 pM 
Reference: Kimoto M., Nakamura M., Hirao I. July 7 2016. Post-ExSELEX stabilization of an unnatural-base DNA aptamer targeting VEGF165 toward pharmaceutical applications. Nucleic Acids Research 44(15): 7487-7494.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Fibrinogen (85A) (T-Modified) (ID# 7986)
Aptamer chemistry: DNA
Aptamer sequence: CCTTCGTTGTCTGCCTTCGTAGCGGATCGAATTACGCGTTAACGGCAACCGATAACGGGACCGATTGCACACCCTTCAGAATTCGCACCA
Target: Fibrinogen
Target chemistry: Protein
Affinity: 6.2 µM 
Reference: Li M., Huanh Z., Du L., Altier C., Fang H., Wang B. 2008. Selecting Aptamers for a Glycoprotein through the Incorporation of the Boronic Acid Moiety. Journal of American Chemical SOciety 138(38): 12636-12638.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: 5TRG2 (ID# 7987)
Aptamer chemistry: RNA
Aptamer sequence: GAGACAAGAATAAACGCTCAAGGCTATAGCACATGGGTAAAACGACTTCGACAGGAGGCTCACAACAGGC
Target: MUC1-5TR-GalNAc; Tn antigen
Target chemistry: Protein
Affinity: 18.6 nM 
Reference: Ferreira, C.S.; Cheung, M.C.; Missailidis, S.; Bisland, S.; Gariepy, J. Phototoxic aptamers selectively enter and kill epithelial cancer cells. Nucleic acids research 2009, 37, 866-876.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: 1-F (ID# 7988)
Aptamer chemistry: DNA
Aptamer sequence: GAGGCATACCAGCTTATTATTGGGGCCGGGGCAAGGGGGGGGTACCGTGGTAGGACAGATAGTAAGTGCAATCTGCGAA
Target: CD117
Target chemistry: Protein
Affinity: 4.24 nM 
Reference: Zhao, N, Pei, S-N, Qi, J, Zeng, Z, Iyer, SP, Lin, P, et al. (2015). Oligonucleotide aptamer-drug conjugates for targeted therapy of acute myeloid leukemia. Biomaterials 67: 42-51Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HupB-4T (ID# 7989)
Aptamer chemistry: DNA
Aptamer sequence: GGGTAGCAGATGGGGGGGGGG
Target: HupB
Target chemistry: Protein
Affinity: 1.72 µM 
Reference: Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: DL650-E3 (ID# 7990)
Aptamer chemistry: RNA
Aptamer sequence: GGCUUUCGGGCUUUCAACAUCAGCCCCUCAGCC
Target: PC-3
Target chemistry: Cells
Affinity: 146 nM 
Reference: Powell Gray B, Kelly L, Ahrens DP et al. Tunable cytotoxic aptamer-drug conjugates for the treatment of prostate cancer. Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.1717705115 (2018)Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: AS1411 (ID# 7991)
Aptamer chemistry: DNA
Aptamer sequence: GGTGGTGGTGGTTGTGGTGGTGGTGG
Target: non-small lung cancer cell A549
Target chemistry: Cells
Affinity: Not Mentioned in Database
Reference: Zhang R, Gu Y, Wang Z, Li Y, Fan Q, Jia Y. Aptamer cell sensor based on porous graphene oxide decorated ion-selective-electrode: Double sensing platform for cell and ion. Biosensors and Bioelectronics. 2018 Jun 15.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Carbonic Anhydrase IX Aptamer (ID# 7992)
Aptamer chemistry: DNA
Aptamer sequence: AGCAGCACAGAGGTCAGATGTGGTGCGCAGTGATGTGGTTGGTCCTATGCGTGCTACCGTCCTATGCGTGCTACCGTGAA
Target: Carbonic anhydrase IX
Target chemistry: Protein
Affinity: n.d. nM 
Reference: Zhu, Lianhua et al. ƒ??CAIX aptamer-functionalized targeted nanobubbles for ultrasound molecular imaging of various tumorsƒ? International journal of nanomedicine vol. 13 6481-6495. 16 Oct. 2018, doi:10.2147/IJN.S176287Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Huizenga ATP-Binding aptamer (ID# 7993)
Aptamer chemistry: DNA
Aptamer sequence: CACCTGGGGGAGTATTGCGGAGGAAGGTTCCAGGTG
Target: ATP
Target chemistry: Protein
Affinity: 956 µM 
Reference: V. C. ??zalp, D. ??am, F. J. Hernandez, L. I. Hernandez, T.  Sch??fer, and H. A. ??ktem, Small molecule detection by lateral flow strips via aptamer-gated silica nanoprobes, Analyst, 2016, 141, 2595.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: B23 LH aptamer (ID# 7995)
Aptamer chemistry: RNA
Aptamer sequence: TATGGTATGCTGTGTGGTATGGGGTGGCGTGCTCT
Target: luteinising hormone
Target chemistry: Protein
Affinity: 321 nM 
Reference: Liang S, Kinghorn AB, Voliotis M, et al. Measuring luteinising hormone pulsatility with a robotic aptamer-enabled electrochemical reader. Nat Commun. 2019;10(1):852. Published 2019 Feb 20. doi:10.1038/s41467-019-08799-6Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Apt37 (ID# 7996)
Aptamer chemistry: DNA
Aptamer sequence: CGGTGCAGTGGATACATGCCAGCCGTAGCCATCGTGGATA
Target: Thymidine Kinase 1
Target chemistry: Protein
Affinity: 570 pM 
Reference: Aptamer-Based Sandwich Assay for Measurement of Thymidine Kinase 1 in Serum of Cancerous Patients  Mahmood Nazari, Seyed Latif Mousavi Gargari, Abbas Sahebghadam Lotfi, Mohammad Javad Rassaee, and Ramezan Ali Taheri  Biochemistry 2019 58 (18), 2373-2383Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Apt69 (ID# 7997)
Aptamer chemistry: DNA
Aptamer sequence: GCGTGCAGCATGACCACCGATGTCACACTTAATGAGAAT
Target: Thymidine Kinase 1
Target chemistry: Protein
Affinity: 510 pM 
Reference: Aptamer-Based Sandwich Assay for Measurement of Thymidine Kinase 1 in Serum of Cancerous Patients  Mahmood Nazari, Seyed Latif Mousavi Gargari, Abbas Sahebghadam Lotfi, Mohammad Javad Rassaee, and Ramezan Ali Taheri  Biochemistry 2019 58 (18), 2373-2383Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: NoPv1 (ID# 8199)
Aptamer chemistry: Peptide
Aptamer sequence: ATAGCAC
Target: PvCesA2
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Colombo, M., Masiero, S., Rosa, S., Caporali, E., Toffolatti, S. L., Mizzotti, C., Tadini, L., Rossi, F., Pellegrino, S., Musetti, R., Velasco, R., Perazzolli, M., Vezzulli, S., & Pesaresi, P. (2020). Nopv1: A synthetic antimicrobial peptide aptamer targeting the causal agents of grapevine downy mildew and potato late blight. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-73027-xMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Lup an 1 allergen β-conglutin (SGQ) (ID# 7785)
Aptamer chemistry: DNA
Aptamer sequence: GGTGGGGGTGG
Target: β-conglutin
Target chemistry: Protein
Affinity: 0.58 nM 
Reference: P Polo. Selection, characterisation and analytical  application of DNA  aptamer against the anaphylactic toxic allergen, β-conglutin, Lup an 1. (Doctoral Thesis). Retrieved from Tesis Doctorals en Xarxa. http://hdl.handle.net/10803/84036.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: R12 (ID# 8217)
Aptamer chemistry: RNA
Aptamer sequence: GGAGGAGGAGGA
Target: Bovine PrP; beta Bovine PrP
Target chemistry: Protein
Affinity: 8.5; 280 nM 
Reference: Kazuyoshi Murakami, Fumiko Nishikawa, Ken Noda, Takashi Yokoyama & Satoshi Nishikawa (2008) Anti-bovine Prion protein RNA aptamer containing tandem GGA repeat interacts both with recombinant bovine prion protein and its β isoform with high affinity, Prion, 2:2, 73-80Tsukasa Mashima, Akimasa Matsugami, Fumiko Nishikawa, Satoshi Nishikawa, Masato Katahira, Unique quadruplex structure and interaction of an RNA aptamer against bovine prion protein, Nucleic Acids Research, Volume 37, Issue 18, 1 October 2009, Pages 6249–6258, https://doi.org/10.1093/nar/gkp647Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Aptamer 1 – Switch antisense (ID# 8040)
Aptamer chemistry: DNA
Aptamer sequence: GACCGCCCCAGCCT
Target: SARS-CoV nucleocapsid, SARS-CoV-2 nucleocapsid
Target chemistry: Protein
Affinity: 4.93 nM 
Reference: Singh NK, Ray P, Carlin AF, Magallanes C, Morgan SC, Laurent LC, Aronoff-Spencer ES, Hall DA. "Hitting the diagnostic sweet spot: Pont-of-care SARS-CoV-2 salivary antigen testing with an off-the-shelf gluocometer". medRxiv preprint. doi: https://doi.org/10.1101/2020.09.24.20200394.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: TfRA4 (ID# 8192)
Aptamer chemistry: RNA
Aptamer sequence: GCGTCGTACCACGC
Target: TfR-positive cells
Target chemistry: Protein
Affinity: 487.3 ±108.8 nM nM 
Reference: Macdonald, J., Houghton, P., Xiang, D., Duan, W., & Shigdar, S. (2016). Truncation and Mutation of a Transferrin Receptor Aptamer Enhances Binding Affinity. Nucleic Acid Therapeutics, 26(6), 348–354. doi:10.1089/nat.2015.0585Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Thrombin (15mer) (ID# 7480)
Aptamer chemistry: DNA
Aptamer sequence: GGTTGGTGTGGTTGG
Target: Thrombin
Target chemistry: Protein
Affinity: 84 nM 
Reference: Bock, Louis, et al. "Selection of single-stranded DNA molecules that bind and inhibit human thrombin." Nature 355, (1992): 564-566.    S Uehara et al. 30 Poly(dA)-Tailed Thrombin DNA Aptamer to Increase DNase-Resistance and Clotting Inhibitory Activity. Bull. Chem. Soc. Jpn. 81(2008): 1485ƒ??1491Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Lead (Pb) binding aptamer (ID# 7709)
Aptamer chemistry: DNA
Aptamer sequence: GGTTGGTGTGGTTGG
Target: Lead (Pb)
Target chemistry: Other
Affinity: Not Mentioned in Database
Reference: B-F Ye et al. "Colorimetric photonic hydrogel aptasensor for the screening of heavy metal ions." Nanoscale 4(2012): 5998-6003.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Short Mitomer2 (ID# 7930)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: CUUAGCCCAUAGCUGGCUGC
Target: Mitochondria
Target chemistry: Other
Affinity: . nM 
Reference: Yuri Tawaraya, Mamoru Hyodo, Mst Naznin Ara, Yuma Yamada, and Hideyoshi Harashima, ƒ??RNA Aptamers for Targeting Mitochondria Using a Mitochondria-Based SELEX Methodƒ? Biol. Pharm. Bull. 37(8) 1411-1415 (2014)Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: SARS-CoV-2 Aptamer 1C – Apta-switch antisense (ID# 8041)
Aptamer chemistry: DNA
Aptamer sequence: TGTCCATTAACGCCC
Target: RBD of the Spike glycoprotein from SARS-CoV-2
Target chemistry: Protein
Affinity: 5.8 nM 
Reference: Singh NK, Ray P, Carlin AF, Magallanes C, Morgan SC, Laurent LC, Aronoff-Spencer ES, Hall DA. "Hitting the diagnostic sweet spot: Pont-of-care SARS-CoV-2 salivary antigen testing with an off-the-shelf gluocometer". medRxiv preprint. doi: https://doi.org/10.1101/2020.09.24.20200394.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Thiol-modified thrombin Aptamer (ID# 8159)
Aptamer chemistry: DNA
Aptamer sequence: CGGTTGGTGTGGTTGG
Target: Thrombin
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: doi:10.1016/j.aca.2013.09.060Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Thrombin (ID# 8194)
Aptamer chemistry: DNA
Aptamer sequence: GGTTGGTGTTGTTGG
Target: α-thrombin
Target chemistry: Protein
Affinity: 123.1 nM 
Reference: Müller, J., Wulffen, B., Pötzsch, B., & Mayer, G. (2007). Multidomain Targeting Generates a High-Affinity Thrombin-Inhibiting Bivalent Aptamer. ChemBioChem, 8(18), 2223–2226. doi:10.1002/cbic.200700535Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: AP32-4 (ID# 8118)
Aptamer chemistry: DNA
Aptamer sequence: CTGTTTGGTAGGCAG
Target: Metronidazole
Target chemistry: Small Organic
Affinity: 77.22 ± 11.27 nM 
Reference: Wei, Hao et al. “Screening and application of a truncated aptamer for high-sensitive fluorescent detection of metronidazole.” Analytica chimica acta vol. 1128 (2020): 203-210. doi:10.1016/j.aca.2020.07.003Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: T30695 (ID# 8164)
Aptamer chemistry: DNA
Aptamer sequence: GGGTGGGTGGGTGGGT
Target: Pb2
Target chemistry: Other
Affinity: Not Mentioned in Database
Reference: https://doi.org/10.1016/j.molliq.2019.111159.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: M4 (ID# 8165)
Aptamer chemistry: DNA
Aptamer sequence: GGGAGGGTGGGTGGGT
Target: Pb2
Target chemistry: Other
Affinity: Not Mentioned in Database
Reference: https://doi.org/10.1016/j.molliq.2019.111159.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: M16 (ID# 8166)
Aptamer chemistry: DNA
Aptamer sequence: GGGTGGGTGGGTGGGA
Target: Pb2
Target chemistry: Other
Affinity: Not Mentioned in Database
Reference: https://doi.org/10.1016/j.molliq.2019.111159.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: M4-16 (ID# 8167)
Aptamer chemistry: DNA
Aptamer sequence: GGGAGGGTGGGTGGGA
Target: Pb2
Target chemistry: Other
Affinity: Not Mentioned in Database
Reference: https://doi.org/10.1016/j.molliq.2019.111159.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: CD133-A15 (ID# 8149)
Aptamer chemistry: RNA
Aptamer sequence: CCCUCCUACAUAGGG
Target: AC133 epitope (CD133)
Target chemistry: Protein
Affinity: 83.2 ± 82.9 nM 
Reference: Shigdar, S. et al. Nov 19, 2012. "RNA aptamers targeting cancer stem cell marker CD133." Elsevier. Cancer Letters.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: S3-2-3 (ID# 8178)
Aptamer chemistry: DNA
Aptamer sequence: ATGGCCAGGGGGGAGGGG
Target: Esophageal cancer cells.
Target chemistry: Cells
Affinity: 265 nM 
Reference: Chen, X., Zhang, Y., Shi, Y., Niu, T., Li, B., & Guo, L. et al. (2021). Evolution of DNA aptamers against esophageal squamous cell carcinoma using cell-SELEX. The Analyst, 146(13), 4180-4187. doi: 10.1039/d1an00634gMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HIV-1 TAR RNA Hairpin Loop (B22-19) (ID# 7473)
Aptamer chemistry: DNA
Aptamer sequence: CCCTAGTTAGCCATCTCCC
Target: HIV-1 TAR RNA Hairpin Loop
Target chemistry: Small Organic
Affinity: 50 nM 
Reference: Sekkai et al. "In Vitro Selection  of DNA Aptamers Against the HIV-1 TAR RNA Hairpin." Antisense and Nucleic Acid Drug Development, 12 (2002): 265-274.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Interleukin-6 receptor (AIR-3A) (ID# 7839)
Aptamer chemistry: RNA
Aptamer sequence: GGGGAGGCUGUGGUGAGGG
Target: Cells presenting IL-6R
Target chemistry: Cells
Affinity: 8.5 nM 
Reference: Meyer C, U Hahn, et al. (2012) Interleukin-6 Receptor specific RNA aptamers for cargo delivery into target cells. RNA BiolMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Ampicillin (AMP17) (ID# 7854)
Aptamer chemistry: DNA
Aptamer sequence: GCGGGCGGTTGTATAGCGG
Target: Ampicillin
Target chemistry: Small Organic
Affinity: 13.4 nM 
Reference: Song KM, Jeong E, Ban C, et al. (2012) Aptasensor for ampicillin using gold nanoparticle based dual fluorescence-colorimetric methods. Anal Bioanal Chem. 402:2153-2161.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Ampicillin (AMP18) (ID# 7855)
Aptamer chemistry: DNA
Aptamer sequence: TTTAGTTGGGGTTCAGTTG
Target: Ampicillin
Target chemistry: Small Organic
Affinity: 9.8 nM 
Reference: Song KM, Jeong E, Ban C, et al. (2012) Aptasensor for ampicillin using gold nanoparticle based dual fluorescence-colorimetric methods. Anal Bioanal Chem. 402:2153-2161.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: EP23 (ID# 8104)
Aptamer chemistry: RNA
Aptamer sequence: ACGUAUCCCUUUUCGCGUA
Target: Epithelial cellular activating molecule (EpCAM)
Target chemistry: Cells
Affinity: 39.89 nM 
Reference: Bell DR, Weber JK, Yin W, Huynh T, Duan W, Zhou R. In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers. Proc Natl Acad Sci U S A. 2020 Apr 14;117(15):8486-8493. doi: 10.1073/pnas.1913242117. Epub 2020 Mar 31. Erratum in: Proc Natl Acad Sci U S A. 2021 Feb 16;118(7): PMID: 32234785; PMCID: PMC7165443.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: CBSA-5335 SF (ID# 8120)
Aptamer chemistry: DNA
Aptamer sequence: GAGACAAGGGACAAGGAG
Target: Cocaine
Target chemistry: Small Organic
Affinity: 36 nM 
Reference: Yu, H., Canoura, J., Guntupalli, B., Lou, X., & Xiao, Y. (2017). A cooperative-binding split aptamer assay for rapid, specific and ultra-sensitive fluorescence detection of cocaine in saliva. Chemical Science, 8(1), 131–141. doi:10.1039/c6sc01833eMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: CD133-B19 (ID# 8150)
Aptamer chemistry: RNA
Aptamer sequence: CAGAACGUAUACUAUUCUG
Target: CD133
Target chemistry: Protein
Affinity: 145.1±75.4 nM 
Reference: Shigdar, S. et al. Nov 19, 2012. "RNA aptamers targeting cancer stem cell marker CD133." Elsevier. Cancer Letters.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: AMP18 (ID# 8232)
Aptamer chemistry: DNA
Aptamer sequence: TTAGTTGGGGTTCAGTTGG
Target: Ampcillin
Target chemistry: Small Organic
Affinity: 9.8 nM 
Reference: Song KM, Jeong E, Jeon W, Cho M, Ban C. Aptasensor for ampicillin using gold nanoparticle based dual fluorescence-colorimetric methods. Anal Bioanal Chem. 2012 Feb;402(6):2153-61. doi: 10.1007/s00216-011-5662-3. Epub 2012 Jan 7. PMID: 22222912.https://pubmed.ncbi.nlm.nih.gov/28917799/Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Epithelial cell adhesion molecule (EpCAM) (EpDT3) (ID# 7739)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GCGACUGGUUACCCGGUCGT
Target: Cancer stem cell marker epithelial cell adhesion molecule
Target chemistry: Protein
Affinity: 54.5 nM 
Reference: S Shigdar et al. RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule. Cancer Sci 102(2011): 991-998.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Peroxidase DNAzyme ([B7]-3-0) (ID# 7834)
Aptamer chemistry: DNA
Aptamer sequence: ATTGGGAGGGATTGGGTGGG
Target: Hemin
Target chemistry: Protein
Affinity: 29 nM 
Reference: Zhu L, et al. (2012) In vitro selection of highly efficient G-quadruplex-based DNAzymes. Anal. Chem. 84: 8383-8390.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: K19 (ID# 7881)
Aptamer chemistry: DNA
Aptamer sequence: GACGCTTACTCAGGTGTGACTCGAAGGGGTTGGGTGGGTTTATACAAATTAATTAATATTGTATGGTATATTTCGAAGGACGCAGATGAAGTCTC
Target: Siglec-5
Target chemistry: Protein
Affinity: 12.37 nM 
Reference: Yang, M. et al. "Developing aptamer probes for acute myelogenous leukemia detection and surface protein biomarker discovery." Journal of Hematology & Oncology 2014, 7:5.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: PF20N-RO-MARAS-84-1 (ID# 8018)
Aptamer chemistry: DNA
Aptamer sequence: GTTGACGGGCGATTGGTCTT
Target: C-reactive Proteins (CRP)
Target chemistry: Protein
Affinity: 23.58 nM 
Reference: Tsao, Shih-Ming, et al.  “Generation of aptamers from a primer-free randomized ssDNA library using magnetic-assisted rapid aptamer selection.”  Scientific Reports 7, (2017):  1-11.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Anti -?1-Adrenergic Receptor-Autoantibodies (Aptamer 110) (ID# 7665)
Aptamer chemistry: DNA
Aptamer sequence: ACAGTAACCGCGTGAGGTCGA
Target: ?1-Adrenoceptor Autoantibodies(AABs)
Target chemistry: Protein
Affinity: n/a nM 
Reference: Haberland, A., et al. "Aptamer Neutralization of Beta1-Adrenoceptor Autoantibodies Isolated From Patients With Cardiomyopathies." Circulation Research, 109 (2011): 986-992.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Ampicillin (AMP4) (ID# 7853)
Aptamer chemistry: DNA
Aptamer sequence: CACGGCATGGTGGGCGTCGTG
Target: Ampicillin
Target chemistry: Small Organic
Affinity: 9.4 nM 
Reference: Song KM, Jeong E, Ban C, et al. (2012) Aptasensor for ampicillin using gold nanoparticle based dual fluorescence-colorimetric methods. Anal Bioanal Chem. 402:2153-2161.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Anti Aflatoxin M1 (ID# 7867)
Aptamer chemistry: DNA
Aptamer sequence: ACTGCTAGAGATTTTCCACAT
Target: Aflatoxin M1
Target chemistry: Protein
Affinity: 0.0182 nM 
Reference: Nguyen. Label Free detection of Aflatoxin M1 with electrochemical Fe3O4/polyaniline-based aptasensorMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.