rpgv/AptaCom huggingface dataset:
Aptamer: P2MC (ID# 8117)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGACCGCTTAAGCTTAAAGGAGCGGTTACGAATGCGATGACTTAGGTACCATTGCACTACGGTACCTAAACAGTTCCTTTGGATCCGAATTCGCCGC
Target: Doxycycline
Target chemistry: Other
Affinity: 0.780 ± 1.76 nM 
Reference: Tickner, Zachary J et al. “Selection of High-Affinity RNA Aptamers That Distinguish between Doxycycline and Tetracycline.” Biochemistry vol. 59,37 (2020): 3473-3486. doi:10.1021/acs.biochem.0c00586Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HGF (H38-15) (ID# 7464)
Aptamer chemistry: DNA
Aptamer sequence: AGATGCCTGTCCAGCATCGAGCGCCAGCTTTGCTGATGGGTGGCCACCCTTGCCCTGGGTTTGAATTTCGATCCTATCGGTAGCTAGACTGCTTTGTCCTCG
Target: Human  Hepatocyte Growth Factor
Target chemistry: Protein
Affinity: 19 nM 
Reference: Saito, Takesh et al. "Generation of Inhibitory DNA Aptamers Against Human  Hepatocyte Growth Factor." DNA and Cell Biology, 24 (2005): 624-633.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Sialyllactose (Sl-11) (ID# 7501)
Aptamer chemistry: DNA
Aptamer sequence: GTACGAATTCACGAGGTTGCCAGCGGGGCCAGCCACTTCTGTCAGTGAATTCCTGCTCGTATATCTACTCGCCCGCCTGCGAGCATGGAGTCGGATCCTCTA
Target: Sialyllactose
Target chemistry: Other
Affinity: 4.9 µM 
Reference: Masud, M, et al. "Sialyllactose-binding modified DNA aptamer bearing additional functionality by SELEX." Bioorganic & Medicinal Chemistry, 12 (2004): 1111-1120.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Hematoporphyrin IX (ID# 7503)
Aptamer chemistry: DNA
Aptamer sequence: TAGGGAATTCGTCGACGGATCCCAATGGGGTCGGGCGGGCCGGGTGTCATGGTGGACGGAGATGGGACGTAGAGGGCGGTCTGCAGGTCGACGCATGCGCCG
Target: Hematoporphyrin IX (HPIX)
Target chemistry: Small Organic
Affinity: 1.6 µM 
Reference: A Okazawa, A Kobayashi, et al. (2000) In vitro selection of hematoporphyrin binding DNA aptamers. Bioorg Med Chem Lett. 10:2653-2656.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Trypanosoma cruzi-Thrombospondin Parasite Receptor (T6) (ID# 7568)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: ACCGAGUCCAGAAGCUUGUAGUACUCAAUACUCAAGCAAGCCCAGCCCUACCAACCCCGGAGCCUAGAUGGAGUUGAAUUCUCCCUAUAGUGAGUCGUAUUAC
Target: Trypanosoma cruzi-Thrombospondin Parasite Receptor
Target chemistry: Cells
Affinity: 400 nM 
Reference: Ulrich et al. "In Vitro Selection of RNA Aptamers That Bind to Cell Adhesion Receptors of Trypanosoma cruzi and Inhibit Cell Invasion." The Journal of Biological Chemistry, 277 (2002): 20756-20762.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: RNA Tobramycin Molecular Beacon (BA 14-2) (ID# 7462)
Aptamer chemistry: RNA
Aptamer sequence: GGAAUGGAUCCACAUCUACGAAGGCUUUGAAGGUGAGACCGUGCAAAUGAGGAUGGUGUGGAUGAUUAGGGUUGUCGGUUUUCACUGCAGACUUGACGAAGCUU
Target: Tobramycin
Target chemistry: Small Organic
Affinity: 16 µM 
Reference: Morse, Daniel. "Direct selection of RNA beacon aptamers." Biochemical and Biophysical Research Communications, 359 (2007): 94ƒ??101.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: L-tryptophan(Trp 70-727) (ID# 7590)
Aptamer chemistry: RNA
Aptamer sequence: GGGAUCCUAAGCUCUAUCGGCUGGACGACGGGGACGCCACUGGACUAGGUAAGCCAGGACCGUACGUCGGGAGCCGUCAGAAUAAAAGCGGCCUAGCGAUCGAU
Target: L-tryptophan
Target chemistry: Protein
Affinity: 15 nM 
Reference: Majerfeld and Yarus. "A diminutive and specific RNA binding site for L-tryptophan." Nucleic Acids Research, 33(2005): 5482-5493.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: C-Reactive Protein (CRP1-1) (ID# 7818)
Aptamer chemistry: RNA
Aptamer sequence: GGGCGAAUUCGGGACUUCGAUCCGUAGUACCCACCAGGCAUACACCAGCACGCGGAGCCAAGGAAAAAUAGUAAACUAGCACUCAGUGCUCGUAUGCGGAAGCU
Target: C-Reactive Protein (CRP)
Target chemistry: Protein
Affinity: 2.25 nM 
Reference: N Orito, Y Kikuchi, et al. High-affinity RNA aptamers to C-reactive protein (CRP): newly developed pre-elution methods for aptamer selection. J. Phys. Conf. Ser. 352(2012): 012042. doi:10.1088/1742-6596/352/1/012042.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: ATP C32 (ID# 7925)
Aptamer chemistry: RNA
Aptamer sequence: GGUUGGCAGCAGAAGAUAGCAGUACACGGGAGCACUACCAUAAAGAAUGAUGAGUGCACUACAAGCGAGUUAUCUCCUUGAUGUCGGUCAAGGGAGGGAUCCUA
Target: ATP
Target chemistry: Small Organic
Affinity: 27 µM 
Reference: Weill L., Louis D., and Sargueil B., 2004.Selection and Evolution of NTP-Specific Aptamers. Nucleic Acids Research, 2004 Vol. 32 No. 17, 5045-5058Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Chitin (Chi#52) (ID# 7844)
Aptamer chemistry: DNA
Aptamer sequence: TAGGGAATTCGTCGACGGATCCCCTAAGGGGGGACTCAGCATTTTGTGCGGGCGGCGCTAACACAATCAGATAGAGCGGGGTTCTCCAGGTCGACGCATGCGCCG
Target: Chitin
Target chemistry: Other
Affinity: Not Mentioned in Database
Reference: Fukusaki E, Kobayashi A, et al. (2000) DNA aptamers that bind to chitin. Bioorg. Med. Chem. Lett. 10:423-425.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Advanced Glycation End Products (Clone 9) (ID# 7533)
Aptamer chemistry: DNA
Aptamer sequence: AGCTCAGAATGGATCCAAACGCTCATAACTCACTCCATACTCACTTGCTGATTCGCCAACAACACACCCTTAAACAGTCCCTTCGACATGAGAATTCGGCCGGATC
Target: Advanced Glycation End products (AGE)
Target chemistry: Protein
Affinity: 1 pM 
Reference: Higashimoto, Y., et al. "In vitro selection of DNA aptamers that block toxic effects of AGE on cultured retinal pericytes." Microvascular Research, 74 (2007): 65-69.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Interleukin-6 receptor (AIR-3) (ID# 7838)
Aptamer chemistry: RNA
Aptamer sequence: GGAAGAAAGAGGUCUGAGACAUUCUCUUAUAGGGGAGGCUGUGGUGAGGGAAUAUUAAGAGAAUUAACGGUCUAGUUCACCUCGACUUCUGGAGUUGACGUUGCUU
Target: Soluable interleukin-6 receptor (sIL-6R)
Target chemistry: Protein
Affinity: 19.7 nM 
Reference: Meyer C, U Hahn, et al. (2012) Interleukin-6 Receptor specific RNA aptamers for cargo delivery into target cells. RNA BiolMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: ATP C27 (ID# 7927)
Aptamer chemistry: RNA
Aptamer sequence: GGUUGGCAGCAGAAGAUAGCAGAACAAGCAGAUCGGCAAGGGUUUCAUUCGGGAUCGAAGGUAACUUGAAUCGUGCGCUGAAUCGUCGGUCAAGGGAGGGAUCCUA
Target: ATP
Target chemistry: Small Organic
Affinity: 21 µM 
Reference: Weill L., Louis D., and Sargueil B., 2004.Selection and Evolution of NTP-Specific Aptamers. Nucleic Acids Research, 2004 Vol. 32 No. 17, 5045-5058Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Amyloid Peptide BetaA4(1ƒ?? 40) (B55) (ID# 7485)
Aptamer chemistry: RNA
Aptamer sequence: GGGAAUUCGAGCUCGGUACCUUUACCGUAAGGCCUGUCUUCGUUUGACAGCGGCUUGUUGACCCUCACACUUUGUACCUGCUGCCAACUGCAGGCAUGCAAGCUUGG
Target: Amyloid Peptide BetaA4(1ƒ?? 40)
Target chemistry: Peptide
Affinity: 29 nM 
Reference: Ylera, Francisco, et al. "Selection of RNA Aptamers to the Alzheimer's Disease Amyloid Peptide." Biochemical and Biophysical Research Communities, 290 (2002): 1583-1588.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: SARS Coronavirus NTPase/Helicase (ES15-1) (ID# 7531)
Aptamer chemistry: RNA
Aptamer sequence: GAUAAUACGACUCACUAUAGGGUUCACUGCAGACUUGACGAAGCUUGCAGAAAAGGGGGAAGAAGAGGGUGAUUCAGGCGAGAGAAUGGAUCCACAUCUACGAAUUC
Target: SARS Coronavirus NTPase/Helicase
Target chemistry: Protein
Affinity: 1.2 nM 
Reference: Jang, K., et al. "Isolation of inhibitory RNA aptamers against severe acute respiratory  syndrome (SARS) coronavirus NTPase/Helicase." Biochemical and Biophysical Research Communications, 366(2008): 738-744.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Trypanosoma cruzi-Laminin Parasite Receptor (L28) (ID# 7566)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: ACCGAGUCCAGAAGCUUGUAGUACUUAUGUCCCAUCGAACGCAGUGUAUCUUGCACCGACUCUCUGCCUAGAUGGAGUUGAAUUCUCCCUAUAGUGAGUCGUAUUAC
Target: Trypanosoma cruz-Laminin Parasite Receptor
Target chemistry: Cells
Affinity: 209 nM 
Reference: Ulrich et al. "In Vitro Selection of RNA Aptamers That Bind to Cell Adhesion Receptors of Trypanosoma cruzi and Inhibit Cell Invasion." The Journal of Biological Chemistry, 277 (2002): 20756-20762.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Trypanosoma cruzi-Fibronectin Parasite Receptor (F4) (ID# 7567)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: ACCGAGUCCAGAAGCUUGUAGUACUGACCCUUCCCGACGCACGGACCAGUGAUGCCAACCCACCCGCCUAGAUGGAGUUGAAUUCUCCCUAUAGUGAGUCGUAUUAC
Target: Trypanosoma cruzi-Fibronectin Parasite Receptor
Target chemistry: Cells
Affinity: 124 nM 
Reference: Ulrich et al. "In Vitro Selection of RNA Aptamers That Bind to Cell Adhesion Receptors of Trypanosoma cruzi and Inhibit Cell Invasion." The Journal of Biological Chemistry, 277 (2002): 20756-20762.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Trypanosoma cruzi-Heparan Parasite Receptor (HS6) (ID# 7570)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: ACCGAGUCCAGAAGCUUGUAGUACUACCGCAACGUUGGCGUUCGGCGUUGGCCGCGUCAUCGCUAGCCUAGAUGGAGUUGAAUUCUCCCUAUAGUGAGUCGUAUUAC
Target: Trypanosoma cruzi-Heparan Parasite Receptor
Target chemistry: Cells
Affinity: 40 nM 
Reference: Ulrich et al. "In Vitro Selection of RNA Aptamers That Bind to Cell Adhesion Receptors of Trypanosoma cruzi and Inhibit Cell Invasion." The Journal of Biological Chemistry, 277 (2002): 20756-20762.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Anterior Gradient Homolog 2 (C14B0) (ID# 7842)
Aptamer chemistry: DNA
Aptamer sequence: TCTCGGACGCGTGTGGTCGGCGGGTGGGAGTTGTGGGGGGGGGTGGGAGGGTTCTTTGTTTGATCTTTCTCGCTGCCTGGCCCTAGAGTGTCGCTGCCTGGCAGAGTG
Target: Anterior Gradient Homolog 2 (AGR2)
Target chemistry: Protein
Affinity: 8.5 nM 
Reference: Wu et al. "Identification, Characterization and Amplification of a G-Quadruplex Structured DNA Aptamer Against Cancer Biomarker Protein Anterior Gradient Homolog 2." PLOS, 9 (2012):e46393.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Tobramycin (J6) (ID# 7458)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGAAUUCCGACCAGAAGCUUAGUAUAGCGAGGUUUAGCUACACUCGUGCUGAUCGUUUGGUACGGGACCUGCGUGUAGCCCAUAUGUGCGUCUACAUGGAUCCUCA
Target: Tobramycin
Target chemistry: Small Organic
Affinity: 2 nM 
Reference: Wang, Yong, et al. "Specific binding of aminoglycoside antibiotics to RNA." Chemistry & Biology 2 (1995): 281-290Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Yeast phenylalanine tRNA (B2) (ID# 7459)
Aptamer chemistry: RNA
Aptamer sequence: GGGAAUUCCGCGUGUGCUACGUAUCUUCAGGCGGUAACUAACUGUGCUGAGUCUAAUCUUUGUGAGGGACGGUAACAUAUGGUUCCCGCGUGGUCCGUUCGGGAUCCUC
Target: Yeast phenylalanine tRNA
Target chemistry: Small Organic
Affinity: 12 nM 
Reference: Scarabino, Daniela, et al. "tRNA prefers to kiss." EMBO Journal 18 (1999): 4571-4578Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: ERK 1/ ERK2 (Family II) (ID# 7546)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGAGCCAUACCUGACAAAGACGCUAGCGAAUUGGUUCCUCACUCAAAAGUAGGGGAAAGCGUUAUUAAGAAACCAAAAUUUGACAGGUUACGCAUCCUGCAUCCUC
Target: Extracellular Regulated Kinase 1 and 2 (ERK 1 and ERK2)
Target chemistry: Protein
Affinity: 4.7 nM 
Reference: Seiwert, S., et al. "RNA aptamers as pathway-specific MAP kinase inhibitors." Chemistry & Biology, 7(2000): 833-834.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Bisphenol A(#3) (ID# 7578)
Aptamer chemistry: DNA
Aptamer sequence: GGGCCGTTCGAACACGAGCATGCCGGTGGGTGGTCAGGTGGGATAGCGTTCCGCGTATGGCCCAGCGCATCACGGGTTCGCACCAGGACAGTACTCAGGTCATCCTAGG
Target: Bisphenol A(BPA)
Target chemistry: Small Organic
Affinity: 8.3 nM 
Reference: Jo et al. "Development of Single-Stranded DNA Aptamers for Specific Bisphenol A Detection." Oligonucleotides, 21(2011): 85-91.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Biotin (ID# 7553)
Aptamer chemistry: RNA
Aptamer sequence: GGAACACUAUCCGAUGGCACCGACCAUAGGCUCGGGUUGCCAGAGGUUCCACACUUUCAUCGAAAAGCCUAUGCUAGGCAAUGACAUGGACUCCUUGGUCAUUAGGAUCG
Target: Biotin
Target chemistry: Small Organic
Affinity: 5.7 µM 
Reference: Wilson et al. "Functional Requirements for Specific Ligand Recognition by a Biotin-Binding RNA Pseudoknot." Journal of Biochemistry, 37(1998): 14410-14419.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Kanamycin B (K8) (ID# 7523)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGCUCGGUACCGAAUUCUCGCCCUAUAGGGGUGUUGAGGGAAAUGUGUGCGACAAGGUGCGGUGGCCAGAACUUUUCGUUCUCAUCAAAAGCUUUGCAGAGGAUCCUU
Target: Kanamycin B
Target chemistry: Small Organic
Affinity: 180 nM 
Reference: Kwon et al., "In Vitro Selection of RNA against Kanamycin B." Molecules and Cells, 11 (2001): 303-311.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Protein Tyrosine Phosphatase (N71yc16) (ID# 7541)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGAUACCAGCUUAUUCAAUUCUGGCAAUGGGCUAUCCCAAGUGCUAGGCUUCAGGGAGCGAGGACCAGACGACGUACCUAACCCUAAGGUGAGAUAGUAAGUGCAAUCU
Target: Protein tyrosine phosphatase (PTPase)
Target chemistry: Protein
Affinity: 18 nM 
Reference: Bell, S., et al. "RNA Molecules That Bind to and Inhibit the Active Site of a Tyrosine Phosphatase." The Journal of Biological Chemistry, 273(1998):14309-14314.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HIV-1 R5 Glycoprotein gp120 (B4) (ID# 7530)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: AAUUAACCCUCACUAAAGGGAACUGUUGUGAGUCUCAUGUCGAAGAGCGGUUAAGGGAGAUUUAGGCAGCAGCUUGGACAGUGUAUCGGCUGAGUUGAGCGUCUAGUCUUGUCU
Target: HIV-1 R5 SU Glycoprotein
Target chemistry: Protein
Affinity: 5 nM 
Reference: Khati, M., et al. "Neutralization of Infectivity of Diverse R5 Clinical Isolates of Human Immunodeficiency Virus Type 1 by gp120-Binding 2'F-RNA Aptamers." Journal of Virology, 77(2003): 12692-12698.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Influenza B Hemagglutinin (A20) (ID# 7808)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGCUCAGCCUUCACUGCACUCCGGCUGGUGGACGCGGUACGAGCAAUUUGUACCGGAUGGAUGUUCGGGCAGCGGUGUGGCAGGGAUGAGCGGCACCACGGUCGGAUCCAC
Target: Influenza B Hemagglutinin (HA)
Target chemistry: Protein
Affinity: 720 pM 
Reference: S. Gopinath et al. An efficient RNA aptamer against human influenza B virus hemagglutinin. J. Biochem. 139(2006): 837-846.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: PrP Fibrils (SAF-93) (ID# 7487)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGACAAGACUAGACGCUCAACUACGAACUCAUGACACAAGGAUGCAAUCUCAUCCCGCCAGCCCACCGUUUCGACAUGAGACUCACAACAGUUCCCUUUAGUGAGGGUUAAUU
Target: PrP Fibrils
Target chemistry: Protein
Affinity: 23.4 nM 
Reference: Rhie, A., et al. "Characterization of 2'-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion." Journal of Biological Chemistry, 278 (2003): 39697-705.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HIV-1 R5 SU Glycoprotein gp120 (B40) (ID# 7731)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGACAAGACUAGACGCUCAAUGUGGGCCACGCCCGAUUUUACGCUUUUACCCGCACGCGAUUGGUUUGUUUUCGACAUGAGACUCACAACAGUUCCCUUUAGUGAGGGUUAAUU
Target: HIV-1 R5 gp120
Target chemistry: Protein
Affinity: 21 nM 
Reference: A. K. Dey et. al. Structural characterization of an anti-gp120 RNA aptamer that neutralizes R5 strains of HIV-1. RNA 11:873-884Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Theophylline + Flavin Mononucleotide (AR7) (ID# 7750)
Aptamer chemistry: RNA
Aptamer sequence: GGAUAAUAGCCGUAGGUUGCGAAAGCGACCCUGAUGAGCCUUAGGAUAUGUCUGGAUACCAUGCAUGAUGCACCUUGGCAGUCUUACAGAAGGACGUCGAAACGGUAGCGAGAGCUC
Target: Theophylline and FMN
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Seetharaman et al. "Immobilized RNA switches for the analysis of complex chemical and biological mixture." Nature Biotechnology, 19(2001):336-341.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Rapt1 (ID# 8055)
Aptamer chemistry: DNA
Aptamer sequence: CTCCCATGCTATTATGGCTAGCGCAGGAGGCCACACCGGA
Target: Recombinant Clostridium Difficile Toxin B
Target chemistry: Protein
Affinity: 8.9 nM 
Reference: Liu, Meng et. al. "In Vitro Selection of a DNA Aptamer Targeting Degraded Protein Fragments for Biosensing" Angewandte Chemie 10.(2020)Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Colicin E3 (F1-1) (ID# 7490)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGAAUUCCGACCAGAAGCUUACUGUCCUCCCUUCAGAGAGCGCGGGACCCUUAACUUGGGGCCCACGAACAGCUUCAGUUCCGUCUCGGCGUCAUAUGUGCGUCUACAUGGAUCCUCA
Target: Colicin E3
Target chemistry: Protein
Affinity: 2 nM 
Reference: Hirao, I., et al. "In Vitro Selection of RNA Aptamers that Bind to Colicin E3 and Structurally  Resemble the Decoding Site of 16S Ribosomal RNA." Biochemistry, 43 (2004): 3214-3221.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: 8-OHdG (22) (ID# 7687)
Aptamer chemistry: DNA
Aptamer sequence: TAATACGACTCACGTATAGGGAATTCGTCGACGGATGCGGGCGATCGGCGGGGGGTGCGTGCGCTCTGTGCCAGGGGGTGGGACAGATCATATGGGGGTGCTCAGGTCGACGCATGCGCCG
Target: 8-OHdG
Target chemistry: Other
Affinity: 0.1 nM 
Reference: Miyachi, Y. (2009). Selection of a dna aptmaer that binds 8-ohdg using gmp-agarose. Bioorganic & Medicinal Chemistry Letters, 19(2009), 3619-3622.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: ppERK2/ERK2 (ID# 7488)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGAGCCAUACCUGACAAAGACGCUAGCGAAUUGGUUCCUCACUCAAAAGUAGGGGAAAGCGUUAUUAAGAAACCAAAAUUUGACAGGUUACGCAUCCUGCAUCCUCCAGGUUACGCAUCC
Target: ppERK2/ERK2
Target chemistry: Protein
Affinity: 4.7 nM 
Reference: Seiwert, S., et al. "RNA aptamers as pathway-specific MAP kinase inhibitors." Chemistry and Biology, 7 (2000): 833-843.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Crude Extracellular Mixture of E. coli – cis (ID# 7647)
Aptamer chemistry: DNA
Aptamer sequence: CACGGATCCTGACAAGGATGTGTGCGTTGTCGAGACCTGCGACCGGAACACTACACTGTGTGGGATGGATTTCTTTACAGTTGTGTGCAGCTCCGTCCGACTCTTCCTAGCTATGGTTCGATCAAGA
Target: Crude Extracellular Mixture (CEM) of E. coli
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Ali et al. "Fluorogenic DNAzyme Probes as Bacterial Indicators." Angewandte Chemie International Edition, 50 (2011): 3751-3754.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Adenosine (ID# 7604)
Aptamer chemistry: DNA
Aptamer sequence: ACTCATCTGTGAGACTCACTATAGGAAGAGATGTCAACTCGTGCACGAGTTGACATCTCTTCTCCGAGCCGGTCGAAATATTGGAGGAAGCTCGAGCTGGAGGAAAAGTGAGTCTCACAGATGAGT
Target: ATP
Target chemistry: Small Organic
Affinity: 1 mM 
Reference: Liu and Lu. "Adenosine-Dependent Assembly of Aptazyme-Functionalized Gold Nanoparticles and Its Application as a Colorimetric Biosensor." Analytical Chemistry, 76 (2004): 1627-1632.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: ADCC Bi-specific Aptamer (bsA17) (ID# 7861)
Aptamer chemistry: DNA
Aptamer sequence: CCACTGCGGGGGTCTATACGTGAGGAAGAAGTGGGCAGGTCGCAGGTCGGAGGGAAAAGTTATCAGGCTGGATGGTAGCTCGGTCGGGGTGGGTGGGTTGGCAAGTCTGATTAGTTTTGGAGTACTCGCTCC
Target: CD16a positive cell lines
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Boltz A, Plater B, Hock B, et al. (2011) Bi-specific Aptamers Mediating Tumour Cell Lysis. J Biol Chem. 286: 21896-21905.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Sialyl Lewis X  (5) (ID# 7465)
Aptamer chemistry: RNA
Aptamer sequence: CCGUAAUACGACUCACUAUAGGGGAGCUCGGUACCGAAUUCAAGGUACUCUGUGCUUGUCGAUGUGUAUUGAUGGCACUUUCGAGUCAACGAGUUGACAGAACAAGUAGUCAAGCUUUGCAGAGAGGAUCCUU
Target: Sialyl Lewis X
Target chemistry: Other
Affinity: 0.085 nM 
Reference: Jeong, Sunjoo, et al. "In Vitro Selection of the RNA Aptamer against the Sialyl Lewis X and Its Inhibition of the Cell Adhesion." Biochemical and Biophysical Research Communications, 281 (2001): 237ƒ??243.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Malaria.1 (ID# 8053)
Aptamer chemistry: DNA
Aptamer sequence: CCAAACGCGCTGGTTTGGAATGCTTAGAGTTTGATCGATGCCTAA
Target: Plasmodium falciparum
Target chemistry: Cells
Affinity: 60 nM 
Reference: Oteng, Eugene, et al. "High-efficiency enrichment enables identification of aptamers to circulating Plasmodium falciparum-infected erythrocytes" Scientific Reports 10, 9706Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Thrombin Aptamer 2 (ID# 8160)
Aptamer chemistry: DNA
Aptamer sequence: TTTTTTTTTTTTTTTTTTTTAGTCCGTGGTAGGGCAGGTTGGGGTGACT
Target: Thrombin
Target chemistry: Protein
Affinity: 0.027 nM 
Reference: doi:10.1039/C7TB01276D Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.