rpgv/AptaCom huggingface dataset:
Aptamer: 1G8-14 (ID# 7934)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGACAAGAAUAAACGCUCAAGGCAUUUCUGCUAGUCUGGUUGUAAGAUAUUCAACACGUGAGUUUCGACAGGAGGCUCACAACAGGC
Target: Ebola virus inhibitory domain (eVP35 IID) (EBOV) (eVP35)
Target chemistry: Protein
Affinity: 3.7 nM 
Reference: Jennifer M. Binning, Tianjiao Wang, Priya Luthra, Reed S. Shabman, Dominika M. Borek, Gai  Liu, Wei Xu, Daisy W. Leung, Christopher F. Basler, and Gaya K. Amarasinghe, ƒ??Development of RNA aptamers targeting ebolavirus VP35ƒ? Biochemistry 2013, 52, 8406-8419.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Apta 3 (ID# 8123)
Aptamer chemistry: DNA
Aptamer sequence: TCGCGCGAGTCGTCTGGGGGGGTGTATCGTTGACGAGTTGCGCGTGCGTCTCGTGCCGCATCGTCCTCCC
Target: Carcinoembryonic antigen (CEA)
Target chemistry: Protein
Affinity: 60.4 nM 
Reference: Melo, M.; Correa, C.; Cunha, P.; Goes, A.; Gomes, D.; Andrade, A. DNA aptamers selection for carcinoembryonic antigen (CEA). Bioorg. Med. Chem. Lett. 2020 May 23; 30(15): 127278. DOI: 10.1016/j.bmcl.2020.127278Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Azo-1 (ID# 8135)
Aptamer chemistry: DNA
Aptamer sequence: TCGCCTTGCCGGATCGCAGAGUAAGGCAGCUUACAAACAUUAAGGCACAGUGGUCCGUGAGCCUGACACC
Target: Human Thrombin
Target chemistry: Protein
Affinity: Not given. nM 
Reference: Morihiro, K.; Hasegawa, O.; Kasahara, Y.; Mori, S.; Kasai, T.; Kuwahara, M.; Obika, S. Azobenzene-modified DNA aptamers evolved by capillary electrophoresis (CE)-SELEX method. Bioorg. Med. Chem. Lett. 2021 Jan 1; 31: 127607. DOI: 10.1016/j.bmcl.2020.127607.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: TROP2 (Tac B1) (ID# 8162)
Aptamer chemistry: DNA
Aptamer sequence: TCGCCTTGCCGGATCGCAGATGCTGTTGTCACCTGCCTCGTCTCCCTCGTUGGUCCGUGAGCCUGACACC
Target: TROP2 FcHis / Human trophoblast antigen 2
Target chemistry: Protein
Affinity: 153 nM 
Reference: Uemachi, H.; Kasahara, Y.; Tanaka, K.; Okuda, T.; Yoneda, Y.; and S. Obika. 2021 . Hybrid-Type SELEX for the Selection of Artificial Nucleic AcidAptamers Exhibiting Cell Internalization Activity. Pharmaceutics 2021, 13, 888. https://doi.org/10.3390/pharmaceutics13060888Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Small-Cell Lung Cancer (HCH07) (ID# 7484)
Aptamer chemistry: DNA
Aptamer sequence: TACCAGTGCGATGCTCAGGCCGATGTCAACTTTTTCTAACTCACTGGTTTTGCCTGACGCATTCGGTTGAC
Target: Small-cell lung cancer (SCLC) cell-surface molecular markers
Target chemistry: Cells
Affinity: 38 nM 
Reference: Chen, Hui, et al. "Molecular Recognition of Small-Cell Lung Cancer Cells Using Aptamers." CHEMMEDCHEM, 3 (2008): 991-1001.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: S. Enterica Serovar Typhi IVP Pili Protein (S-PS8.4) (ID# 7532)
Aptamer chemistry: RNA
Aptamer sequence: GGGAACAGUCCGAGCCUCACUGUUAUCCGAUAGCAGCGCGGGAUGAGGGUCAAUGCGUCAUAGGAUCCCGC
Target: S. Enterica Serovar Typhi IVP Pili Protein
Target chemistry: Protein
Affinity: 7.2 nM 
Reference: Pan, Q., et al. "Aptamers That Preferentially Bind Type IVB Pili and Inhibit Human Monocytic-Cell Invasion by Salmonella enterica Serovar Typhi." Antimicrobial Agents and Chemotherapy, 49(2005): 4052-4060.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Cyclophilin B (M9-5) (ID# 7702)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGGACGAUGCGGGGACCUAUGCAGUAGCCAGUGUGGACUGGGCUGCCCCCCCCAGACGACUCGCCCGA
Target: Cyclophilin B (CypB) pancreatic cell line
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Ray, P. (2012). Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin b as a candidate pancreatic cancer biomarker. J. Clin. Invest., 122(5), 1734-1741. doi: 10.1172/JC162385Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: FMN-inhibited molecular switch (ID# 7765)
Aptamer chemistry: RNA
Aptamer sequence: GGGCGACCCUGAUGAGAUGAGGAUAUGCUUCGGCAGAAGGCUCUCGAAACGGUGAAAGCCGUAGGUUGCCC
Target: flavin mononucleotide (FMN)
Target chemistry: Small Organic
Affinity: na nM 
Reference: Garrett A. Soukup and Ronald R. Breaker. "Engineering precision RNA molecular switches" Proc. Natl. Acad. Sci. 96(1999):3584-3589.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Brain Penetrating Aptamer (A15) (ID# 7840)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGGACGAUGCGGCGUAUUGCGCGAGGAUUAUCCGCUCAUCGUUGUUGUUGUGCAGACGACUCGCCCGA
Target: Brain capillary endothelia and parenchyma
Target chemistry: Tissue
Affinity: Not Mentioned in Database
Reference: Cheng C, B Davidson, et al. (2013) In vivo SELEX for identification of brain-penetrating aptamers. Molecular Therapy - Nucleic Acids 2: e67.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: A15 (ID# 8102)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGGACGAUGCGGCGUAUUGCGCGAGGAUUAUCCGCUCAUCGUUGUUGUUGUGCAGACGACUCGCCCGA
Target: Brain Endothelia Cell
Target chemistry: Cells
Affinity: 48.74 ± 3.11 nM 
Reference: Cheng C, Chen YH, Lennox KA, Behlke MA, Davidson BL. In vivo SELEX for Identification of Brain-penetrating Aptamers. Mol Ther Nucleic Acids. 2013;2(1):e67. Published 2013 Jan 8. doi:10.1038/mtna.2012.59Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: LL4A (ID# 8244)
Aptamer chemistry: DNA
Aptamer sequence: GCTGGACTCACCTCGACCAGAGCCATTGGGTTTCCTAGGAAATAGGGCCTTTACTATGAGCGAGCCTGGCGCTGGACTCACCTCGA
Target: Transmembrane Protein CD63 (vemurafenib-resistant melanoma cells)
Target chemistry: Protein
Affinity: 84.63 ± 13.04 nM 
Reference: Li, Hui et al. “A Novel Aptamer LL4A Specifically Targets Vemurafenib-Resistant Melanoma through Binding to the CD63 Protein.” Molecular therapy. Nucleic acids vol. 18 (2019): 727-738. doi:10.1016/j.omtn.2019.10.005Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Tumour Marker MUC1 (S1.6) (ID# 7491)
Aptamer chemistry: DNA
Aptamer sequence: GGGAGACAAGAATAAACGCTCAAGCAACAGGGTATCCAAAGGATCAAATTCGACAGGAGGCTCACAACAGGC
Target: Tumour Marker MUC
Target chemistry: Peptide
Affinity: 0.2131 nM 
Reference: Ferreira, C., et al. "DNA Aptamers That Bi nd to MUC1 Tumour Marker: Design and Characterization of MUC1-Binding Single-Stranded DNA Aptamers." Tumor Biology, 27(2006): 289ƒ??301.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: C-Reactive Protein (CRP) (ID# 7719)
Aptamer chemistry: DNA
Aptamer sequence: GGCAGGAAGACAAACACGATGGGGGGGTATGATTTGATGTGGTTGTTGCATGATCGTGGTCTGTGGTGCTGT
Target: C-Reactive Protein (CRP)
Target chemistry: Protein
Affinity: 3.51 nM 
Reference: C-J Huang et al. "Integrated microfluidic system for rapid screening of CRP aptamers  utilizing systematic evolution of ligands by exponential enrichment (SELEX)." Biosens. Bioelectron. 25(2010):1761-1766.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: FMN-induced molecular switch (ID# 7759)
Aptamer chemistry: RNA
Aptamer sequence: GGGCGACCCUGAUGAGCCUUAGGAUAUGCUUCGGCAGAAGGACGUCGAAACGGUGAAAGCCGUAGGUUGCCC
Target: flavin mononucleotide (FMN)
Target chemistry: Small Organic
Affinity: na nM 
Reference: Garrett A. Soukup and Ronald R. Breaker. "Engineering precision RNA molecular switches" Proc. Natl. Acad. Sci. 96(1999):3584-3589.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Heparanase (3M NaSCN) (ID# 7789)
Aptamer chemistry: DNA
Aptamer sequence: GGGAGACAAGAATAAACGCTCAATTTAACGTATTTATTCAAGCTCGTATTCGACAGGAGGCTCACAACAGGC
Target: Heparanase (HPSE1)
Target chemistry: Protein
Affinity: 13 nM 
Reference: Simmons, SC, et al. Development of novel single-stranded nucleic acid aptamers against the pro-angiogenic and metastatic enzyme heparanase (HPSE1). PLoS One (2012) 7:e37938.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Heparanase (1.5M NaCl) (ID# 7790)
Aptamer chemistry: DNA
Aptamer sequence: GGGAGACAAGAATAAACGCTCAAATGGACTTTTGAATGTGGCAACAAATTCGACAGGAGGCTCACAACAGGC
Target: Heparanase (HPSE1)
Target chemistry: Protein
Affinity: 12 nM nM 
Reference: Simmons, SC, et al. Development of novel single-stranded nucleic acid aptamers against the pro-angiogenic and metastatic enzyme heparanase (HPSE1). PLoS One (2012) 7:e37938.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Acetylcholine (ACh 6R) (ID# 7807)
Aptamer chemistry: DNA
Aptamer sequence: ATCCGTCACACCTGCTCTCAGGGGATCACATTCTTGACGGTGTGATACAGTGCCTGGTGTTGGCTCCCGTAT
Target: Acetylcholine
Target chemistry: Small Organic
Affinity: Not Mentioned in Database
Reference: J.G. Bruno et al. Development of DNA aptamers for cytochemical detection of acetylcholine. In Vitro Cell. Dev. Biol.-Anim. 44(2008):63-72.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: MUC1 Tumor Marker (MUC1-5TR-1) (ID# 7810)
Aptamer chemistry: DNA
Aptamer sequence: GGGAGACAAGAATAAACGCTCAAGAAGTGAAAATGACAGAACACAACATTCGACAGGAGGCTCACAACAGGC
Target: MUC1 recombinant protein with five repeats of the variable tandem repeat region
Target chemistry: Protein
Affinity: 47.3 nM 
Reference: C Ferreira et al. DNA aptamers against the MUC1 tumour marker: design of aptamer-antibody sandwich ELISA for the early diagnosis of epithelial tumors. Anal. Bioanal. Chem. 390(2008):1039-1050.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Bacillus anthracis spores (BAS-6F) (ID# 7851)
Aptamer chemistry: DNA
Aptamer sequence: ATACGGGAGCCAACACCATCCCTCTTAGGATACAAAGCCAAACTGAGCCCGTGCAGAGCAGGTGTGACGGAT
Target: Bacillus anthracis spores
Target chemistry: Other
Affinity: Not Mentioned in Database
Reference: Bruno, J. G. and Carrillo, M. P. "Development of aptamer beacons for rapid presumptive detection of  Bacillus spores." J Fluoresc, 22 (2012): 915-924.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: M13a (ID# 7911)
Aptamer chemistry: DNA
Aptamer sequence: ACGCTCGGATGCCACTACAGCTAAGCAGGAAGGTATGGATTGGTTGCATTAGCTCATGGACGTGCTGGTGAC
Target: PSL
Target chemistry: Peptide
Affinity: 4.59 µM 
Reference: Hongcheng Mei, Tao Bing, Xiaojuan Yang, Cui Qi, Tianjun Chang, Xiangjun Liu, Zehui Cao, and Dihua Shangguan. 2012. Functional-Group Specific Aptamers Indirectly Recognizing Compounds with Alkyl Amino Group. Anal. Chem. 2012, 84, 7323-7329Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: MUC1-5TR-1 (ID# 7916)
Aptamer chemistry: DNA
Aptamer sequence: GGGAGACAAGAATAAACGCTCAAGAAGTGAAAATGACAGAACACAACATTCGACAGGAGGCTCACAACAGGC
Target: human breast adenocarcinoma (MCF7)
Target chemistry: Cells
Affinity: 47.3 nM 
Reference: John R. Stecker, Alissa A. Savage, John G. Bruno, Dana M. Garcia, Joseph R. Koke. "Dynamics and Visualization of MCF7 Adenocarcinoma Cell Death by Aptamer-C1q-Mediated Membrane Attack" Nucleic Acid Therapeutics, Vol.22, Num.4 (2012)Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Chagas Apt-79 (ID# 7949)
Aptamer chemistry: Chimeric
Aptamer sequence: GGGAGATAATGGTAACGGTUCUUUGUATAAGAATGCACGACACTTCTATAGTGTCACCTAAATGAATTCCGG
Target: T. cruzi Excreted Secreted Antigens (TESA)
Target chemistry: Protein
Affinity: See source nM 
Reference: de Araujo FF, Nagarkatti R, Gupta C, Marino AP, Debrabant A (2015) Aptamer-Based Detection of Disease Biomarkers in Mouse Models for Chagas Drug  Discovery. PLoS Negl Trop Dis 9(1): e3451. doi:10.1371/journal.pntd.0003451Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Hemoglobin Aptamer (ID# 7968)
Aptamer chemistry: DNA
Aptamer sequence: GGCAGGAAGACAAACACCAGGTGAGGGAGACGACGCGAGTGTTAGATGGTAGCTGTTGGTCTGTGGTGCTGT
Target: Hemoglobin
Target chemistry: Protein
Affinity: 7.6 nM 
Reference: J Li et al. On chip, aptamer-based sandwich assay for detection of glycated hemoglobins via magnetic beads. Biosensors and Bioelectronics 79 (2016): 887-893Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Glycated Hemoglobin Aptamer (ID# 7969)
Aptamer chemistry: DNA
Aptamer sequence: TGGCAGGAAGACAAACACATCGTCGCGGCCTTAGGAGGGGCGGACGGGGGGGGGCGTGGTCTGTGGTGCTGT
Target: Glycated Hemoglobin
Target chemistry: Protein
Affinity: 7.3 nM 
Reference: J Li et al. On chip, aptamer-based sandwich assay for detection of glycated hemoglobins via magnetic beads. Biosensors and Bioelectronics 79 (2016): 887-893Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: PSMA Dimeric Aptamer (ID# 8027)
Aptamer chemistry: DNA
Aptamer sequence: GCGTTTTCGCTTTTGCGTTTTGGGTCATCTGCTTACGATAGCAATGCTCGGCAAAAAAAAAAAAAAAAGCCG
Target: Prostate Specific Membrane Antigen (PSMA)
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Boyacioglu, O., Stuart, C. H., Kulik, G., & Gmeiner, W. H. (2013). Dimeric DNA Aptamer Complexes for High-capacity-targeted Drug Delivery Using pH-sensitive Covalent Linkages. Molecular therapy. Nucleic acids, 2(7), e107. https://doi.org/10.1038/mtna.2013.37Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Apt-3 (ID# 8116)
Aptamer chemistry: DNA
Aptamer sequence: ATAGGAGTCGACCGACCAGACCAACCCTACGCGTACCAACCAGATGACCTACGTGCGTCTACATCTAGACTC
Target: C promoter binding factor 1 (CBF1)
Target chemistry: Protein
Affinity: 34 nM 
Reference: Tezuka-Kagajo, Mari et al. “Development of Human CBF1-Targeting Single-Stranded DNA Aptamers with Antiangiogenic Activity In Vitro.” Nucleic acid therapeutics vol. 30,6 (2020): 365-378. doi:10.1089/nat.2020.0875Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: nDNA-547 (ID# 8141)
Aptamer chemistry: DNA
Aptamer sequence: ACCACAACGGTTTCCCAGGACGGATGCTTCCGTAATGACGCTTCCCATTACCCGTCCAATCAACTCAACTTC
Target: nano-sized DNA
Target chemistry: Small Organic
Affinity: 363 ± 135 nM nM 
Reference: Ogawa, A., & Itoh, Y. (2020). In Vitro Selection of RNA Aptamers Binding to Nanosized DNA for Constructing Artificial Riboswitches. ACS Synthetic Biology. doi:10.1021/acssynbio.0c00384Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Hepatitis C Virus Non-Structural Protein 3 (G9-1) (ID# 7529)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGAAUUCCGACCAGAAGCUUCGGGAUUUGAGGGUAGAAUGGGACUACCUUUCCUCUCUCCUUCCUCUUCU
Target: Hepatitis C Virus Non-Structural Protein 3
Target chemistry: Protein
Affinity: 11.6 nM 
Reference: Fukuda, et al. "Isolation and characterization of RNA aptamers specific for the hepatitis C virus nonstructural protein 3 protease." European Journal of Biochemistry, 267(2000): 3685-3694.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Beta 2-Integrin (D20) (ID# 7543)
Aptamer chemistry: RNA
Aptamer sequence: GGGCGCUAAGUCCUCGCUCAUGCGCGUCCCAUGGGGUAUAGAGGGGUCGAAGUGGACGCGCGACUCGGAUCCU
Target: Beta 2-Integrin
Target chemistry: Protein
Affinity: 500 nM 
Reference: Blind, M., et al. "Cytoplasmic RNA modulators of an inside-out signaltransduction cascade." Proceedings of National Academy of Sciences of the United States of America, 96(1999):3606ƒ??3610.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Aflatoxin M1 Aptamer (AFAS3) (ID# 7889)
Aptamer chemistry: DNA
Aptamer sequence: ATCCGTCACACCTGCTCTGACGCTGGGGTCGACCCGGAGAAATCGCATTCCCCTGTGGTGTTGGCTCCCGTAT
Target: Aflatoxin M1
Target chemistry: Small Organic
Affinity: 35.6 nM 
Reference: Malhotra, S., Pandey, A., Rajput, S. and Sharma, R. "Selection of aptamers for Aflatoxin M1 and their characterization." Journal of Molecular Recognition 27 (2014): 493-500.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Apt A1 (ID# 8000)
Aptamer chemistry: DNA
Aptamer sequence: GCAATGGTACGGTACTTCCGTCATCAGCTTGTGATGTGGATGCGAACTGCAAAAGTGCACGCTACTTTGCTAA
Target: BACE1
Target chemistry: Protein
Affinity: 68.6 nM 
Reference: Zhi-Man Liang, et al. “The BACE1-Specific DNA Aptamer A1 Rescues Amyloid-b Pathology and Behavioral Deficits in a Mouse Model of Alzheimer’s Disease”. 00. 00. 2019.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: UA-Mg-1 (ID# 8237)
Aptamer chemistry: DNA
Aptamer sequence: GGAGGCTCTCGGGACGACGGGCAAGAGGTTTTACTTACCTAAGGAATGTCGTGTCGTCCCGACTCTATGATGACTGT
Target: Uric acid (UA)
Target chemistry: Other
Affinity: 7-8 nM 
Reference: Liu, Y., Liu, J., ChemBioChem 2023, 24, e202200564.https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202200564Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: TGF-??1 (T18_1_3) (ID# 7475)
Aptamer chemistry: DNA
Aptamer sequence: CGCTCGGCTTCACGAGATTCGTGTCGTTGTGTCCTGTACCCGCCTTGACCAGTCACTCTAGAGCATCCGGACTG
Target: Transforming Growth Factor-??1 (TGF-??1)
Target chemistry: Protein
Affinity: 94 nM 
Reference: Kang, Jonghoon, et al. "Combinatorial selection of a single stranded DNA thioaptamer targeting TGF-??1 protein." Bioorganic & Medicinal Chemistry Letters, 18 (2008): 1835-1839.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Human Influenza A virus H3N2 (P30-10-16) (ID# 7527)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGAAUUCCGACCAGAAGGGUUAGCAGUCGGCAUGCGGUACAGACAGACCUUUCCUCUCUCCUUCCUCUUCU
Target: Human Influenza A virus H3N2
Target chemistry: Cells
Affinity: 0.188 nM 
Reference: Gopinath, S., et al. "An RNA aptamer that distinguishes between closely related human influenza viruses and inhibits haemagglutinin-mediated membrane fusion." Journal of General Virology, 87(2005): 479-487.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Apta 5 (ID# 8124)
Aptamer chemistry: DNA
Aptamer sequence: TCGCGCGAGTCGTCTGGGAGCTACGTTTAGCGAGTCCGACGCTCGGTGCCTCTTCCCGCATCGTCCTCCC
Target: Carcinoembryonic antigen (CEA)
Target chemistry: Protein
Affinity: 37.8 nM 
Reference: Melo, M.; Correa, C.; Cunha, P.; Goes, A.; Gomes, D.; Andrade, A. DNA aptamers selection for carcinoembryonic antigen (CEA). Bioorg. Med. Chem. Lett. 2020 May 23; 30(15): 127278. DOI: 10.1016/j.bmcl.2020.127278Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HA Clone B (ID# 8182)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGAAUUCCGACCAGAAGGGUUAGCGGUCGUCUUAAGUAGUUUUUGGUCCUUUCCUCUCUCCUUCCUCUUCU
Target: Hemagglutinin of H3N2
Target chemistry: Protein
Affinity: 115 pM 
Reference: Misono, T.S. and Kumar, P.K., 2005. Selection of RNA aptamers against human influenza virus hemagglutinin using surface plasmon resonance. Analytical biochemistry, 342(2), pp.312-317.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: V5 (ID# 8187)
Aptamer chemistry: DNA
Aptamer sequence: CGCTCGGATCGATAAGCTTCGCATAGACCCAGCTGGTCCGGAAAATAAGATGTCACGGATCCTCTAGAGCACTG
Target: Ovarian cancer vessels
Target chemistry: Tissue
Affinity: Not Mentioned in Database
Reference: Wang, Hongyu et al. “Morph-X-Select: Morphology-based tissue aptamer selection for ovarian cancer biomarker discovery.” BioTechniques vol. 61,5 249-259. 1 Nov. 2016, doi:10.2144/000114473Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: C3A WWP1 E3 ligase (ID# 8188)
Aptamer chemistry: DNA
Aptamer sequence: CCGTAATACGACTCACTATAGGTATGTGACGCGCGTCAATCGCTGTCCTACCAAGCTTTGCAGAGAGGATCCTT
Target: C-lobe, HECT domain, WWP1 E3 ligase
Target chemistry: Protein
Affinity: 1.9 nM 
Reference: Tucker, W., Kinghorn, A., Fraser, L., Cheung, Y.-W., & Tanner, J. (2018). Selection and Characterization of a DNA Aptamer Specifically Targeting Human HECT Ubiquitin Ligase WWP1. International Journal of Molecular Sciences, 19(3), 763. doi:10.3390/ijms19030763Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Protein Kinase C-d (ID# 7489)
Aptamer chemistry: DNA
Aptamer sequence: GCCAGGGGTTCCACTACGTAGAACACGACGGGAATACTGACTCTCCCCCATGTACCAGGGGGCAGAGAGAAGGGC
Target: Protein Kinase C-d
Target chemistry: Protein
Affinity: 122 nM 
Reference: Mallikaratchy, P., et al. "Selection of DNA ligands for protein kinase C-d." Chemical Communications, 2006 (2006): 3229-3231.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Unphosphorylated ERK2 (ID# 7655)
Aptamer chemistry: RNA
Aptamer sequence: GGCGUGACCUGAUGAGUCACGCUAAGGAGGAUUUCCGAAAGCGGCUACGGUCCGCCAGUGUUACGAAACGUUCCC
Target: Unphosphorylated ERK2
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Vaish et al. "Monitoring post-translational modifications of proteins with allosteric ribozymes." Nature Biotechnology, 20(2002): 810-815.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: theophylline-inhibited molecular switch (ID# 7763)
Aptamer chemistry: RNA
Aptamer sequence: GGGCGACCCUGAUGAGAUGAUACCAGCCGAAAGGCCCUUGGCAGCUCUCGAAACGGUGAAAGCCGUAGGUUGCCC
Target: theophylline
Target chemistry: Small Organic
Affinity: na nM 
Reference: Garrett A. Soukup and Ronald R. Breaker. "Engineering precision RNA molecular switches" Proc. Natl. Acad. Sci. 96(1999):3584-3589.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.