rpgv/AptaCom huggingface dataset:
Aptamer: Clon-3 (ID# 8193)
Aptamer chemistry: DNA
Aptamer sequence: CCCTCCTCCTAACTGTTCCTACGAAACGAGCTTATGCGTAATGATGACTGTCGTAGTTCG
Target: PD-L1
Target chemistry: Protein
Affinity: 70.1 ± 14.2 nM nM 
Reference: Li, J., Ren, X., Zhao, J., & Lou, X. (2021). PD-L1 aptamer isolation via Modular-SELEX and its applications in cancer cell detection and tumor tissue section imaging. The Analyst, 146(9), 2910–2918. https://doi.org/10.1039/d1an00182eMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: A8 (ID# 8213)
Aptamer chemistry: DNA
Aptamer sequence: GGAGACCGTACCATCTGTTCGTGGAAGCGCTTTGCTCGTCCATTAGCCTTGTGCTCGTGC
Target: Listeria monocytogenes Internalin A
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Ohk, S.H., Koo, O.K., Sen, T., Yamamoto, C.M., Bhunia, A.K., 2010. Antibody-aptamer functionalized fibre-optic biosensor for specific detection of listeria monocytogenes from food. J. Appl. Microbiol. 109, 808–817.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Hepatitis B Virus (HBV) Polymerase (P protein) (A9) (ID# 7644)
Aptamer chemistry: RNA
Aptamer sequence: UGUUCAUGUCCUACUGUUCAAACAAAAAAACUGUGCACAAAAAUAAAUUGGGGCAUGGACA
Target: Hepatitis B Virus (HBV) Polymerase (P protein)
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Feng et al. "A SELEX-Screened Aptamer of Human Hepatitis B Virus  RNA Encapsidation Signal Suppresses Viral Replication." PLoS One, 6(2011): e27862Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Pro-Gastrin Releasing Peptide (ID# 7836)
Aptamer chemistry: DNA
Aptamer sequence: ATACCAGCTTATTCAATTTGCACCACTTATTGTTACTAATCTGAGATAGTAAGTGCAATCT
Target: Pro-gastrin releasing peptide (proGRP)
Target chemistry: Protein
Affinity: 1.2 µM 
Reference: M Mie et al. (2012) Selection of DNA aptamers with affinity for Pro-gastrin-Releasing Peptide (proGRP), a tumor marker for small cell lung cancer. Appl. Biochem. Biotechnol. Published Online ahead of Print: DOI 10.1007/s12010-012-9956-5Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Aptamer 1.12 (ID# 7900)
Aptamer chemistry: DNA
Aptamer sequence: TGGTGGCTGTAGGTCAGCATCTGATCGGGTGTGGGTGGCGTAAAGGGAGCATCGGACAACG
Target: Ochratoxin A (OTA)
Target chemistry: Protein
Affinity: 0.36 µM 
Reference: Jorge A. Cruz-Aguado, Gregory Penner, "Determination of Ochratoxin A with a DNA Aptamer", J. Agric. Food Chem. (2008), 56, 10456-10461.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: NaA43 (ID# 7955)
Aptamer chemistry: DNA
Aptamer sequence: GCGGCGGTACCAGGTCAAAGGTGGGTGAGGGGACGCCAAGAGTCCCCGCGGTTACATAGAG
Target: Sodium Ion
Target chemistry: Other
Affinity: 39.1 mM 
Reference: Torabi, S., Wu, P., McGhee, C., Chen, L., Hwang, K., Zheng, N., Cheng, J., & Lu, Y. (2015) In Vitro Selection of a Sodium-Specific DNAzyme and its Application in Intracellular Sensing. PNAS 112, (19):5903-5908Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Human Hepatocellular carcinoma (TLS11a) (ID# 7672)
Aptamer chemistry: DNA
Aptamer sequence: ACAGCATCCCCATGTGAACAATCGCATTGTGATTGTTACGGTTTCCGCCTCATGGACGTGCTG
Target: Human Hepatocellular carcinoma cell line (LH86)
Target chemistry: Cells
Affinity: 7.16 nM 
Reference: Meng, L. (2012). Targeted delivery of chemotherapy agents using liver cancer-specific aptamer. PloS One, 7(4), doi: 10.1371Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: ERK1/ ERK2 (Family II – Truncated) (ID# 7845)
Aptamer chemistry: RNA
Aptamer sequence: GGAAAGACGCUAGCGAAUUGGUUCCUCGAAAGGGGAAAGCGUUAUUAAGAAACCAAAAUUUCC
Target: Extracellular Regulated Kinase 1 and 2 (ERK 1 and ERK2)
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Seiwert, S., et al. "RNA aptamers as pathway-specific MAP kinase inhibitors." Chemistry & Biology, 7(2000): 833-834.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Sgc-3b (ID# 8069)
Aptamer chemistry: DNA
Aptamer sequence: TTTACTTATTCAATTCCCGTGGGAAGGCTATAGAGGGGCCAGTCTATGAATAAGTTT
Target: Selectin L.
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Bing, T., Shangguan, D., & Wang, Y. (2015). Facile Discovery of Cell-Surface Protein Targets of Cancer Cell Aptamers. Molecular & Cellular Proteomics, 14(10), 2692–2700. doi:10.1074/mcp.m115.051243Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: XQ-P3 (ID# 8137)
Aptamer chemistry: DNA
Aptamer sequence: ACCGACCGTGCTGGACTCATCTCGCTTTTTTCACGGTCCACACTACTATGAGCGAGCCTGGCG
Target: PD-L1
Target chemistry: Protein
Affinity: 15.36 nM 
Reference: Wu X, Li F, Li Y, Yu Y, Liang C, Zhang B, Zhao C, Lu A, Zhang G. A PD-L1 Aptamer Selected by Loss-Gain Cell-SELEX Conjugated with Paclitaxel for Treating Triple-Negative Breast Cancer. Med Sci Monit. 2020 Jun 23;26:e925583. doi: 10.12659/MSM.925583. PMID: 32574155; PMCID: PMC7331476.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: AptD2 (ID# 8163)
Aptamer chemistry: DNA
Aptamer sequence: GGCTGGTCCGCTGGGAACAAGGGCGGGAGGGAGGGTGTGGGTGCGACAAGCGGACCAGCC
Target: DEN-NS1
Target chemistry: Protein
Affinity: 104 nM 
Reference: Ken-ichiro Matsunaga, Michiko Kimoto, Vanessa Weixun Lim, Hui Pen Tan, Yu Qian Wong, William Sun, Shawn Vasoo, Yee Sin Leo, Ichiro Hirao, High-affinity five/six-letter DNA aptamers with superior specificity enabling the detection of dengue NS1 protein variants beyond the serotype identification, Nucleic Acids Research, 2021;, gkab515, https://doi.org/10.1093/nar/gkab515Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: TLR3-ECD (Family-1) (ID# 7606)
Aptamer chemistry: RNA
Aptamer sequence: GGUAGAUACGAUGGAUACCCCCUGUGGCCCGUCAACACAGGGGAAGUGGCAUGACGCGCAGCCA
Target: Toll-like receptor 3 Ectodomain
Target chemistry: Protein
Affinity: 2.1 nM 
Reference: Watanabe et al. "Isolation of RNA aptamers against human Toll-like receptor 3 ectodomain." Nucleic Acids Symposium Series No. 50 (2006): 251-252.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Escherichia coli (E. coli) O157:H7 (ID# 7660)
Aptamer chemistry: Chimeric
Aptamer sequence: GGGUCUUCCUGGACUGUCGAAAAUUCAGUAUCGGGAGGUUACGUAUUUGGUUUAUAGAUAGUAA
Target: Escherichia coli (E. coli) O157:H7
Target chemistry: Cells
Affinity: 110 nM 
Reference: Lee at al. "In vitro selection of Escherichia coli O157:H7-specific RNA aptamer." Biochemical and Biophysical Research Communications, 417(2012): 214-220.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Thrombin (15mer-29-mer dimer with 20T linker) (ID# 7812)
Aptamer chemistry: DNA
Aptamer sequence: GGTTGGTGTGGTTGGTTTTTTTTTTTTTTTTTTTTAGTCCGTGGTAGGGCAGGTTGGGGTGACT
Target: Thrombin
Target chemistry: Protein
Affinity: 0.35 nM 
Reference: H. Hasegawa et al. Improvement of aptamer affinity by dimerization. Sensors 8(2008): 1090-1098.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Mouse Transferrin Receptor (GS24) (ID# 7814)
Aptamer chemistry: DNA
Aptamer sequence: GAATTCCGCGTGTGCACACGGTCACAGTTAGTATCGCTACGTTCTTTGGTAGTCCGTTCGGGAT
Target: Mouse Transferrin Receptor (mTfR)
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: E F Neufeld et al. Aptamer-based endocytosis of a lysosomal enzyme. Proc. Natl. Acad. Sci. USA 105(2008): 15908-15913Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Lysozyme (Apt 60) (ID# 7822)
Aptamer chemistry: DNA
Aptamer sequence: AGCAGCACAGAGGTCAGATGGCAGGTAAGCAGGCGGCTCACAAAACCATTCGCATGCGGC
Target: Hen egg white lysozyme and recombinant human lysozyme
Target chemistry: Protein
Affinity: 3-Feb nM 
Reference: Tran DT, et al. (2010) Selection and characterization of DNA aptamers for egg white lysozyme. Molecules 15: 1127 - 1140.     Zou M et al. (2012) The homogeneous fluorescence anisotropic sensing of salivary lysozyme using the 6-carboxyfluorescein-labeled DNA aptamer. Biosens. Bioelectron. 32: 148-154.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Estrogen Aptamer (AptER-1) (ID# 7879)
Aptamer chemistry: RNA
Aptamer sequence: GGGCAGACGCACCGCGAACAAAACGCAAGACAGAGTGCCGACAAGAGCACTACAAGCTTCTGCCC
Target: Apo-estrogen receptor alpha
Target chemistry: Protein
Affinity: 16 nM 
Reference: Xu, D., Chatakonda, V., Kourtidis, A., Conklin, D., and Shi, H. "In Search of Novel Drug Target Sites on Estrogen Receptors Using RNA Aptamers." Nucleic acid therapeutics 24.3 (2014): 227-38.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: GNP DV2 (ID# 8072)
Aptamer chemistry: DNA
Aptamer sequence: GGAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCG
Target: Dichlorvos (DV)
Target chemistry: Small Organic
Affinity: 0.85 nM 
Reference: Chatterjee, B., Kalyani, N., Anand, A., Khan, E., Das, S., Bansal, V., … Sharma, T. K. (2020). GOLD SELEX: a novel SELEX approach for the development of high-affinity aptamers against small molecules without residual activity. Microchimica Acta, 187(11). doi:10.1007/s00604-020-04577-0Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Hepatitis C NS3 Protein (10G-1) (ID# 7535)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGAGCGGAAGCGUGCUGGGCCAGUAGUGUAUAGGGCUCGAAAUGUUCAUGGCUCAGUGGACAU
Target: Hepatitis C NS3 Protein
Target chemistry: Protein
Affinity: 990 pM 
Reference: Urvil, P., et al. "Selection of RNA  aptamers that bind specifically to the NS3 protease of hepatitis C virus." European Journal of Biochemistry, 248(1997):130-138.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Ochratoxin A (H12) (ID# 7757)
Aptamer chemistry: DNA
Aptamer sequence: GGGAGGACGAAGCGGAACCGGGTGTGGGTGCCTTGATCCAGGGAGTCTCAGAAGACACGCCCGACA
Target: Ochratoxin A (OTA)
Target chemistry: Small Organic
Affinity: 96 nM 
Reference: L Barthelmebs et al. Enzyme-linked aptamer assays (ELAAs), based on a competition format for a rapid and sensitive detection of ochratoxin A in wine. Food Control 22(2011): 737-743Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Hodgkin Lymphoma aptamer (ID# 7886)
Aptamer chemistry: DNA
Aptamer sequence: TACCAGTGCGATGCTCAGTAACTTTGAAGGAAAGGCTACAAACTCTTCCTGACGCATTCGGTTGAC
Target: HDLM2
Target chemistry: Cells
Affinity: 10 nM 
Reference: Parekh, P. et al. "Biostable ssDNA Aptamers Specific for Hodgkin Lymphoma." Sensors 2013, 13: 14543-14557.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Clone 2 (ID# 7902)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: CGACUGCAGAGCUUGCUACGUUGUAAUUCAAAACAAAGGUUUCCUGGACUCCCCGCAGGUCUUGUGAAUGGUACCGAGCUCGAAUUCCC
Target: Protein E (PE)
Target chemistry: Protein
Affinity: 1.2 nM 
Reference: Barfod, Anders et al. "In Vitro Selection of RNA Aptamers Directed Against Protein E: A Haemophilus influenzae Adhesin." Mol Biotech, 2014: 1-12.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HM69 (ID# 8023)
Aptamer chemistry: DNA
Aptamer sequence: TGCGTGTGTAGTGTGTCTGCATGCCCCTGTAATCGCCCATGGGTAGCCTCTTAGGGATTTGGGCGG
Target: Human Embryonic Stem Cells (hESC cells)
Target chemistry: Cells
Affinity: 9.67 nM 
Reference: Wang M, Wu H, Li Q, Yang Y, Che F, Wang G, Zhang L. Novel Aptamer-Functionalized Nanoparticles Enhances Bone Defect Repair By Improving Stem Cell Recruitment. Int J Nanomedicine. 2019;14:8707-8724https://doi.org/10.2147/IJN.S223164Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: DB99 (Clone A) (ID# 8196)
Aptamer chemistry: RNA
Aptamer sequence: CCGCCCAAATCCCTAAGAGCACAAACACCAAACACAACCACCCCAACCAGACACACTACACACGCA
Target: GD2
Target chemistry: Protein
Affinity: 21.21 nM 
Reference: Zhang, L., Wang, M., Zhu, Z., Chen, S., Wu, H., Yang, Y., Che, F., Li, Q., & Li, H. (2021). A GD2-aptamer-mediated, self-assembling nanomedicine for targeted multiple treatments in neuroblastoma theranostics. Molecular therapy. Nucleic acids, 26, 732–748. https://doi.org/10.1016/j.omtn.2021.08.021Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Dopamine (dopa2/c.4) (ID# 7766)
Aptamer chemistry: RNA
Aptamer sequence: GGGAAUUCCGCGUGUGCGCCGCGGAAGAGGGAAUAUAGAGGCCAGCACAUAGUGAGGCCCUCCUCCC
Target: Dopamine
Target chemistry: Small Organic
Affinity: Not Mentioned in Database
Reference: Sequence from C Mannironi, et al. "In Vitro Selection of Dopamine RNA Ligands." Biochemistry, 36 (1997):  9726-973.   Enzyme-linked assay from H Park and I R Paeng. "Development of direct competitive enzyme-linked aptamer assay for determination of dopamine in serum." Analytica Chimica Acta, 685 (2011): 65-73.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Clone 488 (ID# 7915)
Aptamer chemistry: RNA
Aptamer sequence: GCGCTAAGTCCTCGCTCAGCCCAUAAGUUGUCCCAAGUCUUGGGCGCAAAUACAUCCCACGCGCGACTCGGATCCG
Target: SelB
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Klug, S. J. et al. "In vitro selection of RNA aptamers that bind special elongation factor SelB, a protein with multiple RNA-binding sites, reveals one major interaction domain at the carboxyl terminus." RNA, 1995 5: 1180 - 1190.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Bovine Thrombin (T7 05 RNA) (ID# 7472)
Aptamer chemistry: RNA
Aptamer sequence: GCAAUGGUACGGUACUUCCUUUGGAAGAUAGCUGGAGAACUAACCAAAAGUGCACGCUACUUUGCUAA
Target: Bovine Thrombin
Target chemistry: Protein
Affinity: 164 nM 
Reference: X Liu, et al. "RNA aptamers speci?c for bovine thrombin." Journal of Molecular Recognition, 16 (2003): 23-27.  X Liu, et al. "Screening of functional antidotes of RNA aptamers against bovine thrombin." FEBS Lett. 562(2004): 125-128Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Acute myeloid leukemia cells (KH1C12) (ID# 7483)
Aptamer chemistry: DNA
Aptamer sequence: ATCCAGAGTGACGCAGCATGCCCTAGTTACTACTACTCTTTTTAGCAAACTGGACACGGTGGCTTAGT
Target: Acute myeloid leukemia cells (HL60)
Target chemistry: Cells
Affinity: 4.5 nM 
Reference: Sefah, Kwame, et al. "Molecular recognition of acute myeloid leukemia using aptamers." Leukemia, 23 (2009):235-244Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Interleukin 17A/F (IL-17A/F) (AptAF42dope1) (ID# 7706)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGCUAGCUGAUCGUACCAGUAGCGUGGCCUGGGGGGCCUAGUCGUGCGAUACUAACAGCUAACACCC
Target: Interleukin-17A/F
Target chemistry: Protein
Affinity: 35.8 nM 
Reference: Adachi, H et al. (2011). Antagonistic rna aptamer specific to a heterodimeric form of human interleukin-17a/f. Biochimie, 93(2011), 1081-1088. doi: 10.1016/j.biochi.2011.04.003Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Human Matrix Metalloprotease 9 (hMMP-9) (F3) (ID# 7742)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGUUACCAGCCUUCACUGCUCCCGGACGCGUCUGUAUCCGCUACCCGCCGCACCACGGUCGGUCACAC
Target: Human matrix metalloprotease 9 (hMMP-9)
Target chemistry: Protein
Affinity: 8.1 nM 
Reference: S Gomes et al. A 99mTc-MAG3-aptamer for imaging human tumours associated with high level of matrix metalloproteinase-9. Bioconjugate Chem. (2012). Accepted for print. DOI: 10.1021/bc300146c.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: H02 (ID# 7999)
Aptamer chemistry: RNA
Aptamer sequence: GGUUACCAGCCUUCACUGCGGACGGACAGAGAGUGCAACCUGCCGUGCCGCACCACGGUCGGUCACAC
Target: Cells expressing Integrin a5B1 & Recombinant a5B1 Integrin
Target chemistry: Cells
Affinity: 226-329.6 nM 
Reference: Fechter, P.; Cruz Da Silva, E.; Mercier, M.C.; Noulet, F.; Etienne-Seloum, N.; Guenot, D.; Lehmann, M.; Vauchelles, R.; Martin, S.; Lelong-Rebel, I.; Ray, A.M.; Seguin, C.; Dontenwill, M.; Choulier, L. RNA Aptamers Targeting Integrin a5B1 as Probes for Cyto- and Histofluorescence in Glioblastoma. Mol. Ther. –Nucleic Acids. 2019, 17, 63-77.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Tenascin-C (GBI-10) (ID# 7477)
Aptamer chemistry: DNA
Aptamer sequence: GGCTGTTGTGAGCCTCCTCCCAGAGGGAAGACTTTAGGTTCGGTTCACGTCCCGCTTATTCTTACTCCC
Target: Tenascin-C (TNC)
Target chemistry: Protein
Affinity: 150 nM 
Reference: Dion, Daniels, et al. "A tenascin-C aptamer identified by tumor cell SELEX: Systematic evolution of ligands by exponential enrichment." PNAS 100(2003): 15416-15421.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Interleukin-17A/F (IL-17A/F) (APTAF42) (ID# 7525)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGCUAGCUGAUCGUACCCAGUAGCGUGGCAUGGGGUGCCUAGUCGGGCGAUACUAACAGCUAACACCC
Target: Human Interleukin-17A/F
Target chemistry: Protein
Affinity: 72.2 nM 
Reference: Adachi, H., et al. "Antagonistic RNA aptamer specific to a heterodimeric form of human interleukin-17A/F." Biochemie, 93 (2011): 1081-1088.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Keratinocyte Growth Factor (14F) (ID# 7542)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGGACGAUGCGGUGGUCUCCCAAUUCUAAACUUUCUCCAUCGUAUCUGGGCAGACGACUCGCCCGA
Target: Keratinocyte Growth Factor (KGF)
Target chemistry: Protein
Affinity: 0.3 pM 
Reference: Pagratis, N., et al. "Potent 2'-amino-, and 2'-fluoro-2'- deoxyribonucleotide RNA inhibitors of keratinocyte growth factor." Nature Biotechnology, 25(1997):68-73.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Interferon-γ (2’NH2-17) (ID# 7843)
Aptamer chemistry: 2'-NH2-RNA
Aptamer sequence: GGGAGGACGAUGCGGUGGUAGCGCGAUAUAGCGCUGGUAGGGUUGCCGGUGAUCAGACGACUCGCCCGA
Target: Interferon-y/IFN-y/IFNG
Target chemistry: Protein
Affinity: 1.7 nM 
Reference: Kubik, Mark F., et al. "Isolation and Characterization of  2ƒ??-Fluoro-,  2ƒ??-Amino-,  and 2ƒ??-Fluoro-/Amino-Modified  RNA Ligands to  Human  IFN-7 That Inhibit  Receptor  Binding." Journal of Immunology, 159 (1997): 259-267.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Clone 1 (ID# 7901)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: CGACUGCAGAGCUUGCUACGUGAUCAAAUCGAGCUUUAACCCAACAGAGCAUCCGUAUCUAUCCAAAUGGGUACCGAGCUCGAAUUCCC
Target: Protein E (PE)
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Barfod, Anders et al. "In Vitro Selection of RNA Aptamers Directed Against Protein E: A Haemophilus influenzae Adhesin." Mol Biotech, 2014: 1-12.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: R10C5 (ID# 8114)
Aptamer chemistry: DNA
Aptamer sequence: GCAATGGTACGGTACTTCCGGACAGTGCTGAAAACTGTGACCCCCCAAAAGTGCACGCTACTTTGCTAA
Target: Legionella pneumophila (Lp)
Target chemistry: Other
Affinity: 116 nM 
Reference: Saad M, Chinerman D, Tabrizian M, Faucher SP. Identification of two aptamers binding to Legionella pneumophila with high affinity and specificity. Sci Rep. 2020 Jun 4;10(1):9145. doi: 10.1038/s41598-020-65973-3. PMID: 32499557; PMCID: PMC7272621.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: MCP-1 (ADR7) (ID# 7463)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGGACGAUGCGGGAACUCACCGGGAAGAAGCCCGUUCCGUCACAGACAUGUUCCGCAUCGUCCUCCC
Target: Monocyte chemoattractant protein-1 (mouse)
Target chemistry: Protein
Affinity: 180 pM 
Reference: Rhodes, Andrew, et al. "The generation and characterisation of antagonist RNA aptamers to MCP-1." FEBS Letter, 506 (2001): 85-90.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Interferon-? (2’NH2-30) (ID# 7469)
Aptamer chemistry: 2'-NH2-RNA
Aptamer sequence: GGGAGGACGAUGCGGCAGGUAAUUACAUGAAGGUGGGUUAGGUACUUUCAGGGUCAGACGACUCGCCCGA
Target: Interferon-y/IFN-y/IFNG
Target chemistry: Protein
Affinity: 2.7 nM 
Reference: Kubik, Mark F., et al. "Isolation and Characterization of  2ƒ??-Fluoro-,  2ƒ??-Amino-,  and 2ƒ??-Fluoro-/Amino-Modified  RNA Ligands to  Human  IFN-7 That Inhibit  Receptor  Binding." Journal of Immunology, 159 (1997): 259-267.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: OSM (ADR58) (ID# 7499)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGGACGAUGCGGAUCGCCCUGAACCGGCCCAGCAGACUGCUGACGGCACGAUCCGCAUCGUCCUCCC
Target: Human Oncostatin M (OSM)
Target chemistry: Protein
Affinity: 7 nM 
Reference: Rhodes, Andrew, et al. "The generation and characterization of antagonist RNA aptamers to human oncostatin M." Journal of Biological Chemistry, 275 (2000): 28555-28561.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Neurotensin receptor NTS-1 (P19) (ID# 7580)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGGACGAUGCGGACAGAUACGGAACUACAGAGGUCAAUUACGGUGGCCACGCAGACGACUCGCCCGA
Target: Neurotensin receptor NTS-1
Target chemistry: Protein
Affinity: 0.37 nM 
Reference: Daniels et al. "Generation of RNA Aptamers to the G-Protein-Coupled  Receptor for Neurotensin, NTS-1." Journal of Analytical Biochemistry, 305(2002): 214-226.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.