rpgv/AptaCom huggingface dataset:
Aptamer: AP-1 cJun/cJun Aptamer-19 (ID# 7940)
Aptamer chemistry: DNA
Aptamer sequence: GGGAGATCACTTACGGCACCGTATAGTCGTACATGAACGAGTGTGAGTGTTAAGCCTTTGGCGACAGGGCTCGGAACC
Target: Activator Protein-1 Family cJun/cJun Homodimer
Target chemistry: Protein
Affinity: 0.5 nM 
Reference: Walters RD, McSwiggen DT, Goodrich JA, Kugel JF (2014) Selection and Characterization of a DNA Aptamer That Can Discriminate between cJun/cJun and cJun/cFos. PLoS ONE 9(6): e101015. doi:10.1371/journal.pone.0101015Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: GR-3 (ID# 7984)
Aptamer chemistry: DNA
Aptamer sequence: ATCCAGAGTGACGCAGCAGATAAGTAGGTATCCGTTTGAAAAACTTTTCTGACCGTCCGACTATGGACACGGTGGCTTAGT
Target: glucagon receptor (GCGR)
Target chemistry: Protein
Affinity: 52.7?ñ5.1 nM 
Reference: Wang, Guodong, et al. "Selection and characterization of DNA aptamer against glucagon  receptor by cell-SELEX". Nature: Scientific Reports (7): 7179. DOI:10.1038/s41598-017-05840-wMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: GWDB-30 (ID# 8042)
Aptamer chemistry: DNA
Aptamer sequence: ACGTTCGGATCGCACTAGAGCCCAAATCTCAGAAACCCATTCTCTACACACCTTGTACCTTCTGAACGTTCTCACGCA
Target: Calreticulin
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: https://patents.google.com/patent/CN105063056A/enMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: L-Selectin (LD201) (ID# 7466)
Aptamer chemistry: DNA
Aptamer sequence: CTACCTACGATCTGACTAGCCAAGGTAACCAGTACAAGGTGCTAAACGTAATGGCTTCGGCTTACTCTCATGTAGTTCC
Target: L-Selectin
Target chemistry: Protein
Affinity: 1.8 nM 
Reference: Hicke, Brain, et al. "DNA Aptamers Block L-Selectin Function In Vivo  Inhibition of Human Lymphocyte Traf?cking in SCID Mic." Journal of Clinical Investigation, 98 (1996): 2688-2692.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HER3 (A30) (ID# 7478)
Aptamer chemistry: RNA
Aptamer sequence: GAAUUCCGCGUGUGCCAGCGAAAGUUGCGUAUGGGUCACAUCGCAGGCACAUGUCAUCUGGGCGGUCCGUUCGGGAUCC
Target: HER3
Target chemistry: Protein
Affinity: 45 nM 
Reference: Chi-Hong et al. "Inhibition of heregulin signaling by an aptamer that preferentially binds to the oligomeric form of human epidermal growth factor receptor-3." Proceedings of the National Academy of Sciences of the United States of America 100,(2003):9226-9231.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Lysozyme (ID# 7563)
Aptamer chemistry: RNA
Aptamer sequence: GGGAAUGGAUCCACAUCUACGAAUUCAUCAGGGCUAAAGAGTGCAGAGUUACUUAGUUCACUGCAGACUUGACGAAGCUU
Target: Lysozyme
Target chemistry: Protein
Affinity: 31 nM 
Reference: Cox and Ellington. "Automated Selection of Anti-Protein Aptamers." Bioorganic & Medicinal Chemsitry, 9 (2001): 2525-2531/Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Heteroaryl dihydropyrimidine (Aptamer 21) (ID# 7596)
Aptamer chemistry: RNA
Aptamer sequence: GGGUAGGCCAGGCAGCCAACUAGCGAGAGCUUAAAUCUCUGAGCCCGAGAGGGUUCAGUGCUGCUUAUGUGGACGGCUU
Target: Heteroaryldihydropyrimidine (HAP)
Target chemistry: Small Organic
Affinity: 50 nM 
Reference: Lau et al. "Evolution and Protein Packaging of Small-Molecule RNA Aptamers." ACS NANO, 5(2011): 7722-7729.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Apramycin (LGA11) (ID# 7791)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGAAGGCGGCGCGUAGGCGAGCUUUAGGCCCGACAUUCCCCUAAAAAAGCUUGUUCUAUUCGUGGACGAUGCGCAC
Target: Apramycin and other aminolycosides (AMGs)
Target chemistry: Small Organic
Affinity: 28.4 nM 
Reference: N. Derbyshire et al. Toggled RNA aptamers against aminoglycosides allowing facile detection of antibiotics using gold nanoparticle assays. Anal. Chem. (2012) 84: 6595-6602.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Apramycin (LS13) (ID# 7792)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGAAGGCGGCGCGUAGGCGAGCUUUACCAGUUUUAUUUGUUUUAUUGUUAUAUGCUUAUUCGUGGACGAUGCGCAC
Target: Apramycin and other aminolycosides (AMGs)
Target chemistry: Protein
Affinity: 35.9 nM 
Reference: N. Derbyshire et al. Toggled RNA aptamers against aminoglycosides allowing facile detection of antibiotics using gold nanoparticle assays. Anal. Chem. (2012) 84: 6595-6602.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Gentamicin (LGA11) (ID# 7793)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGAAGGCGGCGCGUAGGCGAGCUUUAGGCCCGACAUUCCCCUAAAAAAGCUUGUUCUAUUCGUGGACGAUGCGCAC
Target: Gentamicin and other Aminoglycosides (AMGs)
Target chemistry: Small Organic
Affinity: 22.3 nM 
Reference: N. Derbyshire et al. Toggled RNA aptamers against aminoglycosides allowing facile detection of antibiotics using gold nanoparticle assays. Anal. Chem. (2012) 84: 6595-6602.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Kanamycin (LGA11) (ID# 7794)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGAAGGCGGCGCGUAGGCGAGCUUUAGGCCCGACAUUCCCCUAAAAAAGCUUGUUCUAUUCGUGGACGAUGCGCAC
Target: Kanamycin and other aminoglycosides (AMGs)
Target chemistry: Small Organic
Affinity: 52.8 nM 
Reference: N. Derbyshire et al. Toggled RNA aptamers against aminoglycosides allowing facile detection of antibiotics using gold nanoparticle assays. Anal. Chem. (2012) 84: 6595-6602.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Neomycin (LGA11) (ID# 7795)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGAAGGCGGCGCGUAGGCGAGCUUUAGGCCCGACAUUCCCCUAAAAAAGCUUGUUCUAUUCGUGGACGAUGCGCAC
Target: Neomycin and other aminogycosides (AMGs)
Target chemistry: Small Organic
Affinity: 40.3 nM 
Reference: N. Derbyshire et al. Toggled RNA aptamers against aminoglycosides allowing facile detection of antibiotics using gold nanoparticle assays. Anal. Chem. (2012) 84: 6595-6602.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Paromomycin (LGA11) (ID# 7796)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGAAGGCGGCGCGUAGGCGAGCUUUAGGCCCGACAUUCCCCUAAAAAAGCUUGUUCUAUUCGUGGACGAUGCGCAC
Target: Paromomycin and other Aminoglycosides (AMGs)
Target chemistry: Small Organic
Affinity: 21.4 nM 
Reference: N. Derbyshire et al. Toggled RNA aptamers against aminoglycosides allowing facile detection of antibiotics using gold nanoparticle assays. Anal. Chem. (2012) 84: 6595-6602.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Streptomycin (LGA11) (ID# 7797)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGAAGGCGGCGCGUAGGCGAGCUUUAGGCCCGACAUUCCCCUAAAAAAGCUUGUUCUAUUCGUGGACGAUGCGCAC
Target: Streptomycin and other Aminoglycosides (AMGs)
Target chemistry: Small Organic
Affinity: 49.9 nM 
Reference: N. Derbyshire et al. Toggled RNA aptamers against aminoglycosides allowing facile detection of antibiotics using gold nanoparticle assays. Anal. Chem. (2012) 84: 6595-6602.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Tobramycin (LGA11) (ID# 7798)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGAAGGCGGCGCGUAGGCGAGCUUUAGGCCCGACAUUCCCCUAAAAAAGCUUGUUCUAUUCGUGGACGAUGCGCAC
Target: Tobramycin and other Aminoglycosides (AMGs)
Target chemistry: Small Organic
Affinity: 19.2 nM 
Reference: N. Derbyshire et al. Toggled RNA aptamers against aminoglycosides allowing facile detection of antibiotics using gold nanoparticle assays. Anal. Chem. (2012) 84: 6595-6602.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Gentamycin (LS13) (ID# 7799)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGAAGGCGGCGCGUAGGCGAGCUUUACCAGUUUUAUUUGUUUUAUUGUUAUAUGCUUAUUCGUGGACGAUGCGCAC
Target: Gentamycin and other Aminoglycosides (AMGs)
Target chemistry: Small Organic
Affinity: 26.7 nM 
Reference: N. Derbyshire et al. Toggled RNA aptamers against aminoglycosides allowing facile detection of antibiotics using gold nanoparticle assays. Anal. Chem. (2012) 84: 6595-6602.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Kanamycin (LS13) (ID# 7800)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGAAGGCGGCGCGUAGGCGAGCUUUACCAGUUUUAUUUGUUUUAUUGUUAUAUGCUUAUUCGUGGACGAUGCGCAC
Target: Kanamycin and other Aminoglycosides (AMGs)
Target chemistry: Small Organic
Affinity: 69.9 nM 
Reference: N. Derbyshire et al. Toggled RNA aptamers against aminoglycosides allowing facile detection of antibiotics using gold nanoparticle assays. Anal. Chem. (2012) 84: 6595-6602.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Neomycin (LS13) (ID# 7801)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGAAGGCGGCGCGUAGGCGAGCUUUACCAGUUUUAUUUGUUUUAUUGUUAUAUGCUUAUUCGUGGACGAUGCGCAC
Target: Neomycin and other Aminoglycosides (AMGs)
Target chemistry: Small Organic
Affinity: 37 nM 
Reference: N. Derbyshire et al. Toggled RNA aptamers against aminoglycosides allowing facile detection of antibiotics using gold nanoparticle assays. Anal. Chem. (2012) 84: 6595-6602.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Paromomycin (LS11) (ID# 7802)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGAAGGCGGCGCGUAGGCGAGCUUUACCAGUUUUAUUUGUUUUAUUGUUAUAUGCUUAUUCGUGGACGAUGCGCAC
Target: Paromomycin and other Aminoglycosides (AMGs)
Target chemistry: Small Organic
Affinity: 19.8 nM 
Reference: N. Derbyshire et al. Toggled RNA aptamers against aminoglycosides allowing facile detection of antibiotics using gold nanoparticle assays. Anal. Chem. (2012) 84: 6595-6602.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Streptomycin (LS11) (ID# 7803)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGAAGGCGGCGCGUAGGCGAGCUUUACCAGUUUUAUUUGUUUUAUUGUUAUAUGCUUAUUCGUGGACGAUGCGCAC
Target: Streptomycin and other Aminoglycosides (AMGs)
Target chemistry: Small Organic
Affinity: 19.8 nM 
Reference: N. Derbyshire et al. Toggled RNA aptamers against aminoglycosides allowing facile detection of antibiotics using gold nanoparticle assays. Anal. Chem. (2012) 84: 6595-6602.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Tobramycin (ID# 7804)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGAAGGCGGCGCGUAGGCGAGCUUUACCAGUUUUAUUUGUUUUAUUGUUAUAUGCUUAUUCGUGGACGAUGCGCAC
Target: Tobramycin and other Aminoglycosides (AMGs)
Target chemistry: Small Organic
Affinity: 24.8 nM 
Reference: N. Derbyshire et al. Toggled RNA aptamers against aminoglycosides allowing facile detection of antibiotics using gold nanoparticle assays. Anal. Chem. (2012) 84: 6595-6602.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Mouse Transferrin Receptor (FB4) (ID# 7816)
Aptamer chemistry: RNA
Aptamer sequence: GGGCGAAUUCCGCGUGUGCUGAGGGCGGAAGAACUAAUUUGGGACGGAUUGCGGCCGUUGUCUGUGGCGUCCGUUCGGG
Target: Mouse Transferrin Receptor (mTfR)
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: E F Neufeld et al. Aptamer-based endocytosis of a lysosomal enzyme. Proc. Natl. Acad. Sci. USA 105(2008): 15908-15913Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Plasminogen Activator Inhibitor-1 (paionap-5) (ID# 7829)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGGCCACCAACGACAUUGAACCACGUAGGCUCGUUUCUGAGCCGAUCUCGAUGUUGAUAUAAAUAGUGCCCAUGGAUC
Target: Plasminogen Activator Inhibitor-1
Target chemistry: Protein
Affinity: 1.58 nM 
Reference: Madsen, J.B., et al. "RNA Aptamers as Conformational Probes and Regulatory Agents for Plasminogen Activator Inhibitor-1." Biochemistry, 49, (2010), 4103-4115.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Plasminogen Activator Inhibitor-1 (paionap-40) (ID# 7830)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGGCCACCAACGACAUUUAUCGAAUUGAUAACCUUACGCGAGAGCGUAGUUCGUUGAUAUAAAUAGUGCCCAUGGAUC
Target: Plasminogen Activator Inhibitor-1
Target chemistry: Protein
Affinity: 1.23 nM 
Reference: Madsen, J.B., et al. "RNA Aptamers as Conformational Probes and Regulatory Agents for Plasminogen Activator Inhibitor-1." Biochemistry, 49, (2010), 4103-4115.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: upanap-12 (ID# 7837)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGGCCACCAACGACAUUUGCGACUGUUAUAACCUAACAGCGACGUAAAGAUAGUUGAUAUAAAUAGUGCCCAUGGAUC
Target: Urokinase-type plasminogen activator
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Daniel Miotto Dupont, Jeppe Buur Madsen, Roland Karl Hartmann, et al. Serum-stable RNA aptamers to urokinase-type plasminogen activator blocking receptor binding. RNA 2010 16: 2360-2369Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Atrazine R12.23 (ID# 7936)
Aptamer chemistry: DNA
Aptamer sequence: TGTACCGTCTGAGCGATTCGTACGAACGGCTTTGTACTGTTTGCACTGGCGGATTTAGCCAGTCAGTGTTAAGGAGTGC
Target: Atrazine
Target chemistry: Small Organic
Affinity: 0.62 nM 
Reference: Williams, R.; Crihfield, C.; Gattu, S.; Holland, L.; Sooter, L. In Vitro Selection of a Single-Stranded DNA Molecular Recognition Element against Atrazine. International Journal of Molecular Sciences, 2014, 15, 14332-14347. ISSN 1422-0067 doi: 10.3990/ijms150814332Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Atrazine R12.28 (ID# 7937)
Aptamer chemistry: DNA
Aptamer sequence: TGTACCGTCTGAGCGATTCGTACCATTAGTGGGTGCTCCTTACCTGATGGTCATCTAGCCAGTCAGTGTTAAGGAGTGC
Target: Atrazine
Target chemistry: Small Organic
Affinity: 5.1 nM 
Reference: Williams, R.; Crihfield, C.; Gattu, S.; Holland, L.; Sooter, L. In Vitro Selection of a Single-Stranded DNA Molecular Recognition Element against Atrazine. International Journal of Molecular Sciences, 2014, 15, 14332-14347. ISSN 1422-0067 doi: 10.3990/ijms150814332Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: 21st clone (ID# 8039)
Aptamer chemistry: DNA
Aptamer sequence: AGCGTCGAATACCACTACAGCCCGCACTCAACCACCGTTCCTTTGTTTAATTTTGCACATCTAATGGAGCTCGTGGTCAG
Target: Shp2
Target chemistry: Protein
Affinity: 24.9 nM 
Reference: Zhang, Wei Yun, et al.  “Highly parallel single-molecule amplification approach based on agarose droplet polymerase chain reaction for efficient and cost-effective aptamer selection.”  Analytical Chemistry 84, (2012): 350-355.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: M1 (ID# 8085)
Aptamer chemistry: DNA
Aptamer sequence: ATACGACTCACTATTAGGGACCACATAAACATGCATCGCTCAATAACGGGATATTGTTGTGCTAGACTACTGACTACAA
Target: Maltose-binding protein (MBP)
Target chemistry: Protein
Affinity: 173 nM 
Reference: Wang Y, Li Z, Yu H. Aptamer-Based Western Blot for Selective Protein Recognition. Front Chem. 2020 Oct 29;8:570528. doi: 10.3389/fchem.2020.570528. PMID: 33195056; PMCID: PMC7658645.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: H1 (ID# 8086)
Aptamer chemistry: DNA
Aptamer sequence: ATACGACTCACTATTAGGGATGTCCACCATATAGATCGATTTAAGTCCCTCGTTATTAATGCTAGACTACTGACTACAA
Target: Poly(histidine) tag (His-tag)
Target chemistry: Protein
Affinity: 86 nM 
Reference: Wang Y, Li Z, Yu H. Aptamer-Based Western Blot for Selective Protein Recognition. Front Chem. 2020 Oct 29;8:570528. doi: 10.3389/fchem.2020.570528. PMID: 33195056; PMCID: PMC7658645.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: T2 (ID# 8139)
Aptamer chemistry: DNA
Aptamer sequence: CACTCACGTCAGTGACATGCATGCCGATGACTAGTCGTCACTAGTGCACGTAACGTGCTAGTCAGAAATTTCGCACCAC
Target: Plasmodium vivax lactate dehydrogenase (PvLDH)
Target chemistry: Protein
Affinity: 670 nM 
Reference: Cheung YW, Röthlisberger P, Mechaly AE, et al. Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker. Proc Natl Acad Sci U S A. 2020;117(29):16790-16798. doi:10.1073/pnas.2003267117Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: FANA R8-3 (ID# 8173)
Aptamer chemistry: Chimeric
Aptamer sequence: AAAAGGTAGTGCTGAATTCGGTCGCGATTAACATTAAACCGCATAAAAAGGGTGGCCGGAUUCGCUAUCCAGUUGGCCU
Target: SARS-CoV-2 S Protein
Target chemistry: Protein
Affinity: 68.1 nM 
Reference: Ferreira-Bravo, I. A. and J. J. DeStefano. 2021. Xeno-nucleic Acid (XNA) 2'-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor Binding Domain of SARS-CoV-2 S Protein Block ACE2 Binding. bioRxivhttps://doi.org/10.1101/2021.07.13.452259Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: APT-1 (ID# 8204)
Aptamer chemistry: DNA
Aptamer sequence: GCCTGTTGTGAGCCTCCTAACGACACACCAAACTGGAGCCATGCAGGTAGGAACGGGTACATGCTTATTCTTGTCTCCC
Target: Platelets
Target chemistry: Cells
Affinity: 109.28 nM 
Reference: Alemi, F, et al. The identification of single strand DNA aptamers which specifically bind to platelets using cell SELEX technique. Iranian Journal of Veterinary Science and Technology, 13 (2021): 68-83. doi: https://dx.doi.org/10.22067/ijvst.2021.72518.1079Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: STR1 (ID# 8231)
Aptamer chemistry: DNA
Aptamer sequence: TAGGGAATTCGTCGACGGATCCGGGGTCTGGTGTTCTGCTTTGTTCTGTCGGGTCGTCTGCAGGTCGACGCATGCGCCG
Target: Streptomycin
Target chemistry: Small Organic
Affinity: 199.1 nM 
Reference: Zhou N, Wang J, Zhang J, Li C, Tian Y, Wang J. Selection and identification of streptomycin-specific single-stranded DNA aptamers and the application in the detection of streptomycin in honey. Talanta. 2013 Apr 15;108:109-16. doi: 10.1016/j.talanta.2013.01.064. Epub 2013 Feb 28. PMID: 23601877.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HIV-1 Reverse Transcriptase (4.3) (ID# 7470)
Aptamer chemistry: DNA
Aptamer sequence: AGCAGCACAGAGGTCAGATGGCAGGTTTCGACGTACAATGCTATGGAGGCTTTATGATCGCCTATGCGTGCTACCGTGAA
Target: HIV-1 RT
Target chemistry: Protein
Affinity: 190 pM 
Reference: Mosing et al. "Capillary Electrophoresis-SELEX Selection of  Aptamers with Affinity for HIV-1 Reverse Transcriptase." Analytical Chemistry, 77 (2005): 6107-6112.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Kanamycin A (sla 16) (ID# 7555)
Aptamer chemistry: RNA
Aptamer sequence: GGGAAUGGAUCCACAUCUACGAAUUCACCGCGGGGUUGCGGACCGGGAGCUCCAGCUUCACUGCAGACUUGACGAAGCUU
Target: Kanamycin A
Target chemistry: Small Organic
Affinity: 300 nM 
Reference: Lato et al. "In vitro selection of RNA lectins: using combinatorial chemistry to interpret ribozyme evolution." Chemistry & Biology, 2(1995): 291-303.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Phenylalanine (ID# 7559)
Aptamer chemistry: RNA
Aptamer sequence: AUUGGAUCGGUAGUAUUUAGGGUGAGACACUUCAUGCCUUUGUUGCAGGCUGGGGUGAAGGCGCUACAUGGCGUCUGAAA
Target: Phenylalanine
Target chemistry: Small Organic
Affinity: 34 µM 
Reference: Illangasekare and Marus. "Phenylalanine-Binding RNAs and Genetic Code Evolution." Journal of Molecular Evolution, 54(2002): 298-311.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: PCB72 (Aptamer 9.3) (ID# 7620)
Aptamer chemistry: DNA
Aptamer sequence: AGCAGCACAGAGGTCAGATGCACTCGGACCCCATTCTCCTTCCATCCCTCATCCGTCCACCCTATGCGTGCTACCGTGAA
Target: Polychlorinated biphenyl 72 (PCB)
Target chemistry: Small Organic
Affinity: 66 nM 
Reference: Mehta et al. "Selection and characterization of PCB-binding DNA aptamers." Analytical Chemistry 84(2012): 1669-1676.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: PCB106 (Aptamer 9.3) (ID# 7621)
Aptamer chemistry: DNA
Aptamer sequence: AGCAGCACAGAGGTCAGATGCACTCGGACCCCATTCTCCTTCCATCCCTCATCCGTCCACCCTATGCGTGCTACCGTGAA
Target: Polychlorinated biphenyl 106 (PCB)
Target chemistry: Small Organic
Affinity: 99 nM 
Reference: Mehta et al. "Selection and characterization of PCB-binding DNA aptamers." Analytical Chemistry, 84(2012): 1669-1676.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Interleukin 10 (IL-10) Receptor (R5A1) (ID# 7676)
Aptamer chemistry: RNA
Aptamer sequence: GGGCUCAUGCACGUUUGCUCCUGUAAUUGGCGUAUGUAACCCAGGCACCAAACACCCCAGGCCGGGCCAUGAUCCACAUA
Target: Interleukin -10 receptor (IL-10)
Target chemistry: Protein
Affinity: 12 nM 
Reference: Berezhnoy, A, et al. (2012). Isolation and optimization of murine il-10 receptor blocking oligonucleotide aptamers using high- throughput sequencing. The American Society of Gene & Cell TherapyMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Chloramphenicol-binding aptamer(c7) (ID# 7711)
Aptamer chemistry: DNA
Aptamer sequence: AGCAGCACAGAGGTCAGATGACTTCAGTGAGTTGTCCCACGGTCGGCGAGTCGGTGGTAGCCTATGCGTGCTACCGTGAA
Target: chloramphenicol (cam)
Target chemistry: Small Organic
Affinity: 0.766 µM 
Reference: J Mehta et al. In vitro selection and characterization of DNA aptamers recognizing chloramphenicol. J. Biotechnol. 155(2011): 361-369.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.