rpgv/AptaCom huggingface dataset:
Aptamer: Human Norovirus SMV-25 (ID# 7933)
Aptamer chemistry: DNA
Aptamer sequence: AGTATACGTATTACCTGCAGCCATCTGTGTGAAGACTATATGGCGCTCACATATTTCTTTCCGATATCTCGGAGATCTTGC
Target: Human Norovirus
Target chemistry: Other
Affinity: 232 nM 
Reference: Escudero-Abarca BI, Suh SH, Moore MD, Dwivedi HP, Jaykus L-A (2014) Selection, Characterization and Application of Nucleic Acid Aptamers for the Capture and Detection of Human Norovirus Strains. PLoS ONE 9(9): e106805. doi:10.1371/journal.pone.0106805Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Aptamer 25 (ID# 7941)
Aptamer chemistry: DNA
Aptamer sequence: AGTATACGTATTACCTGCAGCCATCTGTGTGAAGACTATATGGCGCTCACATATTTCTTTCCGATATCTCGGAGATCTTGC
Target: Human norovirus (SMV-VLP)
Target chemistry: Other
Affinity: 232 nM 
Reference: Escudero-Abarca, B. I. et al.  "Selection, Characterization and Application of Nucleic Acid Aptamers for the Capture and Detection of Human Norovirus Strains."  PLOS One 2014: 1-11.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: CAP/CAM Aptamer (ID# 7981)
Aptamer chemistry: RNA
Aptamer sequence: AGCAGCACAGAGGTCAGATGACTTCAGTGAGTTGTCCCACGGTCGGCGAGTCGGTGGTAGCCTATGCGTGCTACCCGTGAA
Target: Chloramphenicol
Target chemistry: Other
Affinity: 7.7 µM 
Reference: Mehta J, Van Dorst B, Rouah-Martin E, et al. (2010) In vitro selection and characterication of DNA aptamers recognizing chloramphenicol. Journal of Biotechnology 155: 361-369.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: IR-A43 (ID# 8101)
Aptamer chemistry: DNA
Aptamer sequence: TATGAGTGACCGTCCGCCTGTATCCGCAGTATCGGCATTCAGCGACCCGGGCCACGACAACAGCCACACCACCAGCCAAA
Target: recombinant insulin receptor extracellular domain
Target chemistry: Protein
Affinity: 70 nM 
Reference: Yunn NO, Park M, Park S, Lee J, Noh J, Shin E, Ryu SH. A hotspot for enhancing insulin receptor activation revealed by a conformation-specific allosteric aptamer. Nucleic Acids Res. 2021 Jan 25;49(2):700-712. doi: 10.1093/nar/gkaa1247. PMID: 33410883; PMCID: PMC7826266.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: C42 (ID# 8109)
Aptamer chemistry: DNA
Aptamer sequence: GCTGTGTGACTCCTGCAATGGTAGCGGGTAGGGGAGGGAGGGTGAATGGAGGATGTTCATGGCAGCTGTATCTTGTCTCC
Target: Human PD1
Target chemistry: Cells
Affinity: 23 nM 
Reference: Khedri M, Abnous K, Rafatpanah H, Nabavinia MS, Taghdisi SM, Ramezani M. Development and Evaluation of Novel Aptamers Specific for Human PD1 Using Hybrid Systematic Evolution of Ligands by Exponential Enrichment Approach. Immunol Invest. 2020 Jul;49(5):535-554. doi: 10.1080/08820139.2020.1744639. Epub 2020 May 19. PMID: 32429721.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Bovine Catalase (CAT 1) (ID# 7692)
Aptamer chemistry: DNA
Aptamer sequence: CTTCTGCCCGCCTCCTTCCGACCTAGCAGTGGACATGTGGCAGGGTGAAGTGGCATCGTCGGAGACGAGATAGGCGGACACT
Target: Bovine Catalase
Target chemistry: Protein
Affinity: 237 nM 
Reference: Ashley, J. et al. Selection of bovine catalase aptamers using non-selex. Electrophoresis 33(2012):2783-2789.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: G-NB3 (ID# 8113)
Aptamer chemistry: DNA
Aptamer sequence: GATTGTTACTGTCACGAGGATTGGGGGTTGGGTGGATAGGCTGGCGTCGGGGCAGGTCAGTATAGCACATTAGTTCAGATAC
Target: Activated Protein C
Target chemistry: Protein
Affinity: 0.17 nM 
Reference: Hamedani, N. S., Müller, J., Tolle, F., Rühl, H., Pezeshkpoor, B., Liphardt, K., … Pötzsch, B. (2020). Selective Modulation of the Protease Activated Protein C Using Exosite Inhibiting Aptamers. Nucleic Acid Therapeutics. doi:10.1089/nat.2020.0844Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Hepatitis C Virus RdRp (r10/43) (ID# 7476)
Aptamer chemistry: DNA
Aptamer sequence: GGGAGACAAGAATAAACGCTCAAGGGCGTGGTGGGTGGGGTACTAATAATGTGCGTTTGTTCGACAGGAGGCTCACAACAGGC
Target: Hepatitis C Virus RdRp
Target chemistry: Protein
Affinity: 1.3 nM 
Reference: Jones et al. "High-Affinity Aptamers to Subtype 3a Hepatitis C Virus Polymerase Display Genotypic Specificity." Antimicrobial Agents and Chemotherapy, 50 (2006): 3019-3027.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: L-Valine (ID# 7554)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGCUCAGAAUAAACGCUCAAAUCCGUGGACAGGGCGUAAGCGCCUUCGACAUGAGACACGGAUCCUGCGACGAAUUCAGC
Target: L-Valine
Target chemistry: Small Organic
Affinity: 12 mM 
Reference: Majerfeld and Yarus. "An RNA Pocket for an Aliphatic Hyrdrophobe." Nature Structural Biology, 1(1994): 287-292.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Vaccinia virusƒ??infected A549 cells (TV08) (ID# 7663)
Aptamer chemistry: DNA
Aptamer sequence: ATCGTCTGCTCCGTCCAATATGATGACACCTGCATAATTTATAGTGAGTCTTGATTCACGCTGCATTTGGTGTGAGGTCGTGC
Target: Vaccinia virus (WR Strain)ƒ??infected A549 cells
Target chemistry: Cells
Affinity: 2.7 nM 
Reference: Tang et al. "Generating Aptamers for Recognition of Virus-Infected Cells." Clin. Chem., 55(2009): 813-822.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Anti-NF-kB p65 (R1) (ID# 7752)
Aptamer chemistry: RNA
Aptamer sequence: GAAGCUUACAAGAAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUGGGUCGAAUUCCGCUCA
Target: NF-kB p65
Target chemistry: Protein
Affinity: 11 nM 
Reference: Wurster, S. E, and Maher, L. J. "Selection and characterization of anti-NF-kB p65 aptamers." RNA, 14(2008): 1037-1047.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Anti Glioblastoma Cells (GBM128) (ID# 7873)
Aptamer chemistry: DNA
Aptamer sequence: GAATTCAGTCGGACAGCGACGGTGGGAGCCCCAAATAATTCTTGCGATTATTAGTGTAAGCGGATGGACGAATATCGTCTCCC
Target: Glioblastoma Cell
Target chemistry: Cells
Affinity: 20 nM 
Reference: Kang et al. Selection of DNA Aptamers against Glioblastoma Cells  with High Affinity and Specificity (PLOSone)Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Aptamer TY04 (ID# 7938)
Aptamer chemistry: DNA
Aptamer sequence: ATCGTCTGCTCCGTCCAATATATCAAAGGCGAATTTTGTCAAGGTGTTAAACGATAGTCCCTACCTTTGGTGTGAGGTCGTGC
Target: Multiple myeloma cells (MM.1S)
Target chemistry: Cells
Affinity: Not Mentioned in Database
Reference: Dai, H. et al. "Aptamer TY04 inhibits the growth of multiple myeloma cells via cell cycle arrest."  Tumor Biology 2014: 1-8.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: GBM128 (ID# 7943)
Aptamer chemistry: DNA
Aptamer sequence: GAATTCAGTCGGACAGCGACGGTGGGAGCCCCAAATAATTCTTGCGATTATTAGTGTAAGCGGATGGACGAATATCGTCTCCC
Target: Glioblastoma
Target chemistry: Cells
Affinity: 20 nM 
Reference: Kang D, Wang J, Zhang W, Song Y, Li X, et al. (2012) Selection of DNA Aptamers against Glioblastoma Cells with High Affinity and Specificity. PLoS  ONE 7(10): e42731. doi:10.1371/journal.pone.0042731Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: RA16 (ID# 8056)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGAGAACAAUGACCUGCGGUGCCAAGCCGUCGGGUUAUGUUGAUCUCCUCAAGGACGAGUGCAUUGCAUCACGUCAGUAG
Target: NCl-H460
Target chemistry: Cells
Affinity: 24.75\u2009±\u20092.28 nM 
Reference: Wang, Hanlu, et al. “In Vivo SELEX of an Inhibitory NSCLC-Specific RNA Aptamer from PEGylated RNA Library.” Molecular Therapy - Nucleic Acids, Cell Press, 9 Dec. 2017, www.sciencedirect.com/science/article/pii/S2162253117303013.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Hepatocyte Growth Factor Receptor (CLN0003) (ID# 7860)
Aptamer chemistry: DNA
Aptamer sequence: GGAGGGAAAAGTTATCAGGCTGGATGGTAGCTCGGTCGGGGTGGGTGGGTTGGCAAGTCTGATTAGTTTTGGAGTACTCGCTCC
Target: HGF-R / c-Met
Target chemistry: Protein
Affinity: 0.091 nM 
Reference: Boltz A, Plater B, Hock B, et al. (2011) Bi-specific Aptamers Mediating Tumour Cell Lysis. J Biol Chem. 286: 21896-21905Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Cortisol Aptamer 15-1 (ID# 8004)
Aptamer chemistry: DNA
Aptamer sequence: GAATGGATCCACATCCATGGATGGGCAATGCGGGGTGGAGAATGGTTGCCGCACTTCGGCTTCACTGCAGACTTGACGAAGCTT
Target: Cortisol
Target chemistry: Small Organic
Affinity: 16.1 nM 
Reference: Martin, J. A., Chávez, J. L., Chushak, Y., Chapleau, R. R., Hagen, J., & Kelley-Loughnane, N. (2014). Tunable stringency aptamer selection and gold nanoparticle assay for detection of cortisol. Anal. Bioanal. Chem. 2015 Mar 13; 406(19): 4637–4647. doi:10.1007/s00216-014-7883-8Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: hIL-10RA Aptamer (#411-J) (ID# 8005)
Aptamer chemistry: RNA
Aptamer sequence: CCCAUCCCUCUUCCUCUCUCCCUCGGUACUGCUACAGCAAUGCAUCUACGUCUCUGUGGAUUCGACGACUCGCUGAGAUCGAGA
Target: hIL-10RA
Target chemistry: Protein
Affinity: 18 nM 
Reference: Levay, Agata, et al. “ Identifying high-affinity aptamer ligands with defined cross-reactivity using high-throughput guided systematic evolution of ligands by exponential enrichment.” Nucleic Acids Research 12, (2015): 1-10.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: PL1 (ID# 8058)
Aptamer chemistry: DNA
Aptamer sequence: ATACCAGCTTATTCAATTGTAGAGTATAAAAAGAGTGATGATCTTTTGTAGGTTTTTTAGATAGTAAGTGCAATCT
Target: PD-L1
Target chemistry: Protein
Affinity: 81.46-110 nM 
Reference: Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: TV06 (ID# 8067)
Aptamer chemistry: DNA
Aptamer sequence: ATCCAGAGTGACGCAGCACGGCACTCACTCTTTGTTAAGTGGTCTGCTTCTTAACCTTCATCGACACGGTGGCTTA
Target: STIP1 (TOV-21G, Ovarian Cancer)
Target chemistry: Protein
Affinity: Not Mentioned in Database
Reference: Van Simaeys, D., Turek, D., Champanhac, C., Vaizer, J., Sefah, K., Zhen, J., … Tan, W. (2014). Identification of Cell Membrane Protein Stress-Induced Phosphoprotein 1 as a Potential Ovarian Cancer Biomarker Using Aptamers Selected by Cell Systematic Evolution of Ligands by Exponential Enrichment. Analytical Chemistry, 86(9), 4521–4527. doi:10.1021/ac500466xMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: PP3 (ID# 8068)
Aptamer chemistry: DNA
Aptamer sequence: ATCCAGAGTGACGCAGCACGAGCCAGACATCTCACACCTGTTGCATATACATTTTGCATGGACACGGTGGCTTAGT
Target: Hemagglutinin
Target chemistry: Protein
Affinity: 2.61-3.87 nM 
Reference: Parekh, P., Tang, Z., Turner, P. C., Moyer, R. W., & Tan, W. (2010). Aptamers Recognizing Glycosylated Hemagglutinin Expressed on the Surface of Vaccinia Virus-Infected Cells. Analytical Chemistry, 82(20), 8642–8649. doi:10.1021/ac101801jMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: G123 (ID# 8206)
Aptamer chemistry: DNA
Aptamer sequence: CACGACGCAAGGGACCACAGGGAGGGAGGGTGGGCAAAGGGCCCTAAGTCCGTAACAAAAACACAGCACGACACCGCAGAGGCA
Target: CXCL9
Target chemistry: Protein
Affinity: 78-106 nM 
Reference: Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: E. Coli Release Factor 1 (Clone II-1) (ID# 7528)
Aptamer chemistry: RNA
Aptamer sequence: GGACCGAGAAGUUACCCUGUAAUCUUAGGAUGAAUCGCAUGCUCUAGCGACCUUUUCGGCUUCGGCGUACGCACAUCGCAGCAAC
Target: E. Coli Release Factor 1
Target chemistry: Small Organic
Affinity: 30 nM 
Reference: Sando, et al. "In vitro selection of RNA aptamer against Escherichia coli release factor 1." Bioorganic & Medicinal Chemistry Letters, 17(2007): 1216-1220.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Trypanosoma brucei (2-16) (ID# 7548)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGACGAUAUUCGUCCAUUCGGGUGGCCCGUGUCUGAGCGGGGACGGCCACUUGAGCGCCGCUGUCCGACUGAAUUCUCGACC
Target: Trypanosoma brucei
Target chemistry: Cells
Affinity: 0.75 nM 
Reference: Homann and Goringer. "Combinatorial selection of high affinity RNA ligands to live African trypanosome." Nucleic Acid Research, 27(1999): 2006-2014.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: ADP (ID# 7653)
Aptamer chemistry: RNA
Aptamer sequence: GGGCGACCCUGAUGAGCACACGAGGGGGAAACCCCGGACAAUCAGACACGGUGUUCGAAACGGUGAAAGCCGUAGGUUGCCCUUU
Target: ADP
Target chemistry: Small Organic
Affinity: Not Mentioned in Database
Reference: Srinivasan et al. "ADP-Specific Sensors Enable Universal Assay of Protein Kinase Activity." Chemistry & Biology, 11(2004): 499-508.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Non-small Cell Lung Cancer (S6) (ID# 7662)
Aptamer chemistry: DNA
Aptamer sequence: ACGCTCGGATGCCACTACAGGTGGCCAGTCACTCAATTGGGTGTAGGGGTGGGGATTGTGGGTTGCTCATGGACGTGCTGGTGAC
Target: Non-small Cell Lung Cancer
Target chemistry: Cells
Affinity: 28.2 nM 
Reference: Zhao et al. "Recognition of subtype non-small cell lung cancer by DNA aptamers selected  from living cells." Analyst 134(2009):1808-1814.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Anti-NF-kB p65 (D1) (ID# 7754)
Aptamer chemistry: RNA
Aptamer sequence: GCAUGCAGUGUCUAUUCUCGAGUAGCGAUCGUUGAAGGGGUAUAAGGUUGGCAGAUCGCUAGCAUGCAACUGACUCGGAUAAGCA
Target: Anti-NF-kB p65
Target chemistry: Protein
Affinity: 149 nM 
Reference: Wurster, S. E, and Maher, L. J. "Selection and characterization of anti-NF-kB p65 aptamers." RNA, 14(2008): 1037-1047.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Lysozyme (Apt 80) (ID# 7821)
Aptamer chemistry: DNA
Aptamer sequence: AGCAGCACAGAGGTCAGATGGCAGGTAAGCAGGCGGCTCACAAAACCATTCGCATGCGGCCCTATGCGTGCTACCGTGAA
Target: Hen egg white lysozyme and recombinant human lysozyme
Target chemistry: Protein
Affinity: 2.8 nM 
Reference: Tran DT, et al. (2010) Selection and characterization of DNA aptamers for egg white lysozyme. Molecules 15: 1127 - 1140.     Zou M et al. (2012) The homogeneous fluorescence anisotropic sensing of salivary lysozyme using the 6-carboxyfluorescein-labeled DNA aptamer. Biosens. Bioelectron. 32: 148-154.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: M3 Aptamer (ID# 8007)
Aptamer chemistry: DNA
Aptamer sequence: AAGGAGCAGCGTGGAGGATATACACCGTCATCAGAGGGAGCATCTCTAGTCAGGACTGTGATGAATTAGGGTGTGTCGTCGTGGT
Target: MDA-MB-231 cells
Target chemistry: Cells
Affinity: 45.6 nM 
Reference: Li, W.M.; Zhou, L.L.; Zheng, M.; Fang, J. Selection of Metastatic Breast Cancer Cell-Specific Aptamers for the Capture of CTCs with a Metastatic Phenotype by Cell-SELEX. Mol. Ther. Nucleic Acids 2018, 12, 707-717.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: RNA aptamer-1-based sensitive detection of SARS-CoV nucleocapsid protein (ID# 8030)
Aptamer chemistry: RNA
Aptamer sequence: GGGAGAGCGGAAGCGUGCUGGGCCUGUCGUUCGCUGUGUCUUGCUACGUUACGUUACACGGUUGGCAUAACCCAGAGGUCGAUGG
Target: SARS-CoV Nucleocapsid (N) Protein
Target chemistry: Protein
Affinity: 1.65 nM 
Reference: Ahn, Dae-Gyun,et al. "RNA aptamer-based sensitive detection of SARS coronavirus nucleocapsid protein" The Royal Society of Chemistry, (2009):1896-1901.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: OS-7.9 Aptamer (ID# 8190)
Aptamer chemistry: DNA
Aptamer sequence: ATCCAGAGTGACGCAGCAGGGCACATTGTTCACACACAGATCACATTACGGAAAACACAACTACACGAAATGTCGTTGGTGGCCC
Target: Human Osteosarcoma MG-63
Target chemistry: Cells
Affinity: 12.8 nM 
Reference: Tsogtbaatar, K., Sousa, D. A., Ferreira, D., Tevlek, A., Aydın, H. M., Çelik, E., & Rodrigues, L. (2021). In vitro selection of DNA aptamers against human osteosarcoma. Investigational New Drugs. doi:10.1007/s10637-021-01161-yMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Ricin Toxin (C5) (ID# 7457)
Aptamer chemistry: DNA
Aptamer sequence: ATAGGAGTCACGACGACCAGAACCGTAGGTTCGGGGCGGAGTGGTCCGGAAGGTGGCGTGGTATGTGCGTCTACCTCTTGACTAAT
Target: Ricin Toxin
Target chemistry: Small Organic
Affinity: 58 nM 
Reference: J Tang et al. "The DNA aptamers that specifically  recognize ricin toxin are selected by two in vitro selection method." Electrophoresis, 27 (2006): 1303-1311.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Insulin Receptor Antibody (MA20) (#1) (ID# 7474)
Aptamer chemistry: 2'-NH2-RNA
Aptamer sequence: GGGAGAGCGGAAGCGUGCUGGGCCUGGUUGCUGUAAAAAUAGACACGAAUCUGCCGACCAUAACCCAGAGGUCGAUGGAUCCCCCC
Target: Insulin Receptor Antibody (MA20)
Target chemistry: Antibody
Affinity: 30 nM 
Reference: Lee, Seong-Wook and Sullenger, Bruce A. "Isolation of a Nuclease-resistant Decoy RNA That Selectively Blocks  Autoantibody Binding to Insulin Receptors on Human Lymphocytes." Journal of Experimental Medicine, 184 (1996): 315-324.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: Prion Protein (ID# 7557)
Aptamer chemistry: 2'-NH2-RNA
Aptamer sequence: GGGAGAAAGGGAAGCUUGAGGUGCUAUGGAGUGGAGGAGUUGAAGGUGUCGGGGUUGGCAGAAGAAGGCGAGCGUACGGAUCCAUC
Target: Prion Protein
Target chemistry: Protein
Affinity: 100 nM 
Reference: Proske et al. "Prion-Protein-Specific Aptamer Reduces PrPSc Formation." Chem-Biochem, 3(2002): 717-725.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: LPS (B2) (ID# 7686)
Aptamer chemistry: DNA
Aptamer sequence: CTTCTGCCCGCCTCCTTCCTAGCCGGATCGCGCTGGCCAGATGATATAAAGGGTCAGCCCCCCAGGAGACGAGATAGGCGGACACT
Target: Lipopolysaccharide (LPS)
Target chemistry: Small Organic
Affinity: 12 nM 
Reference: Kim, S. (2012). Harnessing aptamers for electrochemical detection of endotoxin. Analytical Biochemistry ,424(2012), 12-20. doi: 10.1016/j.ab.2012.02.016Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: MUC1 (MA3) (ID# 7725)
Aptamer chemistry: DNA
Aptamer sequence: AACCGCCCAAATCCCTAAGAGTCGGACTGCAACCTATGCTATCGTTGATGTCTGTCCAAGCAACACAGACACACTACACACGCACA
Target: MUC1
Target chemistry: Protein
Affinity: 38.3 nM 
Reference: Y Hu et al. Novel MUC1 aptamer selectively delivers cytotoxic agent to cancer cells in vitro. PLoS ONE 7(2012): e31970.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: CD4 (aptamer 12) (ID# 7735)
Aptamer chemistry: 2'-F-RNA
Aptamer sequence: GGGAGACAAGAAUAAACGCUCAAGUGACGUCCUGAUCGAUUGUGCAUUCGGUGUGACGAUCUUUCGACAGGAGGCUCACAACAGGC
Target: CD4 protein found on CD4+ T-Cells
Target chemistry: Protein
Affinity: 0.5 nM 
Reference: K A Davis et al. "Staining of cell surface human CD4 with 2'-F-pyrimidine-containing RNA aptamers for flow cytometry." Nucleic Acids Res 26(1998):3915-3924.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HER-2 (HB5) (ID# 7745)
Aptamer chemistry: DNA
Aptamer sequence: AACCGCCCAAATCCCTAAGAGTCTGCACTTGTCATTTTGTATATGTATTTGGTTTTTGGCTCTCACAGACACACTACACACGCACA
Target: HER2 peptide
Target chemistry: Protein
Affinity: 18.9 nM 
Reference: Z Liu et al. Novel HER2 aptamer selectively delivers cytotoxic drug to HER2-positive breast cancer cells in vitro. J Transl Med 10(2012): 148-157.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: HAE N55 (ID# 7942)
Aptamer chemistry: DNA
Aptamer sequence: ATACCAGCTTATTCAATTCCCAAATTGCCACCACTTACAGCATGATAACATACTACATCTTTTCATCAAGATAGTAAGTGCAATCT
Target: Inflamed Human Aortic Endothelial Cells
Target chemistry: Cells
Affinity: 82 nM 
Reference: Ji, Kaili., Lim, Wee Siang., Li, Sam Fong Yau., Bhakoo, Kishore. (2013) A two-step stimulus-response cell-SELEX method to generate a DNA aptamer to recognize inflamed human aortic endothelial cells as a potential in vivo molecular probe for atherosclerosis plaque detection. Anal Bioanal Chem (2013) 405:6853-6861. DOI 10.1007//s00216-013-7155-zMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: EF508 (ID# 8096)
Aptamer chemistry: DNA
Aptamer sequence: TAGGGAAGAGAAGGACATATGATACTGGCCTTGACACCCTGTTGTGGCTTGATGACAATAACATTGACTAGTACATGACCACTTGA
Target: Enterococcus faecalis bacteria
Target chemistry: Other
Affinity: 37 nM 
Reference: Kolm C, Cervenka I, Aschl UJ, et al. DNA aptamers against bacterial cells can be efficiently selected by a SELEX process using state-of-the art qPCR and ultra-deep sequencing. Sci Rep. 2020;10(1):20917. Published 2020 Dec 1. doi:10.1038/s41598-020-77221-9Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Aptamer: SP6 (ID# 8169)
Aptamer chemistry: DNA
Aptamer sequence: GGGAGAGGAGGGAGATAGATATCAACCCATGGTAGGTATTGCTTGGTAGGGATAGTGGGCTTGATGTTTCGTGGATGCCACAGGAC
Target: SARS-Co V-2 Spike (RBD independent mechanism to neutralize SARS-CoV-2)
Target chemistry: Protein
Affinity: 21 ± 4.6 nM 
Reference: Schmitz, A., Weber, A., Bayin, M., Breuers, S., Fieberg, V., Famulok, M., & Mayer, G. (2021). A SARS‐CoV‐2 Spike Binding DNA Aptamer that Inhibits Pseudovirus Infection by an RBD‐Independent Mechanism. Angewandte Chemie International Edition, 60(18), 10279-10285.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.