rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
SOLACEA-H in Heparin-sparing Haemodialysis
Status: Not yet recruiting

The aim of the study is to evaluate the efficacy of the SOLACEA-H dialyser, particularly in patients at high risk of haemorrhage, during post-dilution haemodiafiltration sessions with complete or partial heparin sparing. It will be compared with another dialyser (HYDROLINK-NVU)

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  On haemodialysis for at least 3 months Dialysis in a haemodialysis department of the Ramsay-Santé group No active infection Medically stable Blood flow ≥ 300 ml/min Haemoglobin level stable and within recommended norms for a dialysis patient, id est > 10g/dl Bipunction No known allergy to SOLACEA H or HYDROLINK-NVU Willingness to comply with study procedures for the duration of the study For women of childbearing age: effective contraception, or absence of active pregnancy (negative pregnancy test) Member or beneficiary of a social security scheme Patient having been informed and having signed an informed consent form  Exclusion Criteria:  Patient on oral anticoagulants for the duration of the study Patient on dialysate for the duration of the study Patient Medically unstable or fragile Severe hepatic impairment Patient hospitalised without consent Concurrent participation in another clinical study Protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision Pregnant, breast-feeding or parturient women Patient unable to receive heparin Known allergy to latex or phthalates - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Trueness of Full Arch Scans and Generated Digital Implant Models
Status: Not yet recruiting

The goal of this clinical trial study is to evaluate the accuracy of the full digital workflow for four-implant, screw-retained mandibular hybrid prostheses in patients with completely edentulous mandible.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients having a completely edentulous lower arch that could be restored by fixed screw-retained implant hybrid dentures. Patients having a substantial bone height and width at prospective implant sites to install four standard-size inter-foraminal implants. Sufficient crown height space according to criteria of all-on-4. good oral hygiene and motivation  Exclusion Criteria:  Patients with bad oral hygiene. Patients with limited mouth opening. Vulnerable groups. Uncooperative patients. Patients receiving or undergoing radiotherapy or chemotherapy. Patients with systemic diseases affecting bone metabolism. Smokers - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 45 Years - MaximumAge: 60 Years - StdAgeList: Adult
Effect of Kinesio Taping Versus Myofascial Release on Menstrual Low Back Pain
Status: Not yet recruiting

the aim of this study is to investigate the efficacy of kinesio taping versus myofascial release technique on menstrual low back pain in young females

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Healthy young virgin females suffering from menstrual low back pain diagnosed by the gynecologist. Their ages will be ranged from 18-25 years&#39; old Their body mass index will be ranged from 20-25 kg/m2. All females have regular menstruation  Their pain intensity is scored as &gt; 4 on VAS just before or during the first 3 days of the menstruation  -  Exclusion Criteria:  Females will be excluded from the study if they have:  Any orthopedic problems such as trauma at lower spine, congenital malformation at spine and scoliosis. Any gynecological problem such as irregular menstrual cycle, secondary dysmenorrhea due to endometriosis, ovarian cyst, uterine fibroid and congenital malformation or pelvic inflammation. Athletic females  Allergy to kinesio taping.  - - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - GenderBased: Yes - GenderDescription: this study for girls suffering from menstrual LBP clinically diagnosed by the gynecologist. - MinimumAge: 18 Years - MaximumAge: 25 Years - StdAgeList: Adult
Aggressive Risk-Prevention Therapies for Coronary Atherosclerotic Plaque (ART-CAP)
Status: Not yet recruiting

The purpose of this study is to evaluate the effect medication on your heart. All patients between 18-80 years of age, at intermediate or high risk for coronary heart disease (calculated based on age, gender, race, and history of smoking, diabetes, high blood pressure, high cholesterol, family history of early coronary heart disease) with/without symptoms suggestive of heart disease, including chest pain or shortness of breath on exertion, will be selected to take part in this study. CT scan will be used to assess to see if the prescribed treatment changes the blood vessels in heart.

The investigators are doing this study because they want to develop better tools to predict, diagnose, and treat coronary heart disease. This research will help improve care for patients with coronary heart disease by evaluating heart vessel narrowing and improving the decision-making for treatment.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Non-obstructive atherosclerotic coronary artery plaque (stenosis of 0-39% or stenosis of 40-69% with FFR-CT >0.8) in a major epicardial vessel > 2 mm in diameter.  Exclusion Criteria:  coronary/PAD/carotid revascularization or ischemic stroke or TIA within 6 months prior to enrollment Valvular heart disease of moderate or worse severity or requiring interventional procedures or surgery LVEF <35% in the past 12 months Pulmonary hypertension with PASP>50 mm Hg in the past 12 months Myocarditis or pericarditis in the past 12 months Known Cardiomyopathy (hypertrophic, infiltrative, restrictive, dilated, etc.) Heart failure NYHA class 3 or 4 Hospitalization for heart failure in the preceding 6 months Life expectancy of <1 year An organ-transplant recipient or if felt to require listing for solid organ transplantation during study status Inability to give informed consent Active malignancy (except basal cell skin cancer) Cirrhosis ESRD Pregnancy or planning to conceive during the study period Known intolerance or perceived contraindication to any of the study drugs during the study period including statins or aspirin if indicated eGFR<30 ml/min/m2 Inability to receive iodinated contrast for CCTA Chronic immunosuppression therapy Uncontrolled psychiatric illness - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult
Posterior Innominate Mobilization Versus Muscle Energy Technique on Lumbopelvic Angles in Sacroiliac Joint Dysfunction
Status: Recruiting

the goal of this clinical trial study is to compare between posterior innominate mobilization and muscle energy techniqueon lumbopelvic angles in sacroiliac joint dysfunction patients.

the main questions they aim to answer are

are there statistical significant effects of posterior innominate mobilization versus muscle energy technique on lumbopelvic angles in sacroiliac joint dysfunction patients ?

are there statistical significant effects of posterior innominate mobilization versus muscle energy technique on pain intensity level in sacroiliac joint dysfunction patients ?

purpose of the study is to measure the effect of muscle energy technique versus posterior innominate mobilization on lumbopelvic angles in sacroiliac joint dysfunction

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Internal torsion of ilium on sacrum in sacroiliac joint dysfunction patients Normal weight - BMI greater than or equal to 18.5 to 24.9 kg/m^2 Patients with age from 25 to 45 Patients with VAS more than 3 Pain around SIJ and groin area Patients testing positive at least 3 of six SIJ pain provocation tests (Ganesen's test, Distraction test, Compression test, Thigh thrust test, Sacral thrust test, Patrick and fabric test)  Exclusion Criteria:  Underlying neuro defects in leg Sacroiliitis Spondylolisthesis Pre diagnosed disease of central or peripheral nervous system Current pregnancy Rheumatological disease History of major surgery of lower extremity or spine Osteoporosis Recent injection of corticosteroids in SIJ - HealthyVolunteers: No - Gender: All - MinimumAge: 25 Years - MaximumAge: 45 Years - StdAgeList: Adult
Short Term Effect of Wearing a Tie
Status: Not yet recruiting

The goal of this randomized controlled study is to assess the short term effect of wearing a ties on musculoskeletal system. In this scope viscoelastic properties and the mechanosensitivity of the muscles, and cervical range of motion will be measured. In addition to these measurements activity limitation due to wearing a tie and trunk mobility will be assessed.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age of 18 to 25 years Given a signed consent Low level of physical activity Having a BMI between 18 kg/m2 and 25 kg/m2 No pain in neck, upper and lower back (numerical pain rating scale below 3 points)  Exclusion Criteria:  Having a systemic or metabolic disease Having a mental disorder Chronic drug use Any condition that may result in muscle atrophy Musculoskeletal surgery history in last 3 months Having a cervical, thoracal or lumbar radiculopathy or myelopathy Having a whiplash syndrome or fibromyalgia Having performed any strenuous exercises within the 24 h prior to measurements - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Male - GenderBased: Yes - GenderDescription: Participants' gender must be stated as male in their identity - MinimumAge: 18 Years - MaximumAge: 25 Years - StdAgeList: Adult
Prehab Prior to Stem Cell Transplantation in Multiple Myeloma
Status: Not yet recruiting

The primary purpose of this study is to see if individuals with Multiple Myeloma are able and interested in taking part in a tailored exercise program while undergoing their chemotherapy prior to a stem cell transplant. We also hope to learn if this type of program, along with a flexible delivery format (in-person and virtual), helps in maintaining or improving physical fitness, muscle mass and strength, and quality of life during chemotherapy.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Have a diagnosis of Multiple Myeloma Be transplant eligible Be undergoing chemotherapy prior to an autologous stem cell transplant as part of their cancer treatment Be an Alberta resident Be ≥18 years of age Be able to read and understand English.  Exclusion Criteria:  Their disease status/comorbidities preclude exercise testing or participation They are unable to commit to the 10-week exercise program and/or testing sessions at the Cancer Rehabilitation Clinic at the University of Alberta They do not have regular access to the internet and/or an electronic device in the home. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
A Flexible Individualized ExeRcise Programme for Cancer Patients During ChEmotherapy
Status: Not yet recruiting

The primary aim of this study is to measure the feasibility of delivering a co-designed exercise programme for patients with cancer receiving chemotherapy treatment.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Aged >18. Histological confirmed diagnosis of stage I to IIIc breast or colorectal cancer. Scheduled to receive chemotherapy ± immunotherapy with curative intent. Medical clearance from oncologist to partake in regular exercise in accordance with American College of Sports Medicine (ACSM) preparticipation screening algorithm. Ability to provide written informed consent.  Exclusion Criteria:  Advanced/metastatic disease. Scheduled to receive concurrent chemoradiotherapy. Scheduled to receive high-dose chemotherapy during hospital admission. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Physiologically Based Cord Clamping To Improve Neonatal Outcomes In Moderate And Late Preterm Newborns
Status: Recruiting

Before birth, the baby's lungs are filled with fluid and babies do not use the lungs to breathe, as the oxygen comes from the placenta. As delivery approaches, the lungs begin to absorb the fluid. After vaginal delivery, the umbilical cord is clamped and cut after a delay that allows some of the blood in the umbilical cord and placenta to flow back into the baby. Meanwhile, as the baby breathes for the first time, the lungs fill with air and more fluid is pushed out. However, it does not always work out that way.

A baby born prematurely may have breathing problems because of extra fluid staying in the lungs related to the immaturity of the lung structure. Thus, the baby must breathe quicker and harder to get enough oxygen enter into the lungs. The newborn is separated from the mother to provide emergency respiratory support. Although the baby is usually getting better within one or two days, the treatment requires close monitoring, breathing help, and nutritional help as the baby is too tired to suck and swallow milk. Sometimes, the baby cannot recover well and show greater trouble breathing needing intensive care. This further separates the mother and her baby. A possible mean to help the baby to adapt better after a premature birth while staying close to the mother is to delay cord clamping when efficient breathing is established, either spontaneously or after receiving breathing help at birth. In this study, we intend to test this procedure in moderate or late preterm infants and see whether the technique helps the baby to better adapt after birth and to better initiate a deep bond with the mother.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Pregnant women followed-up in Brugmann University Hospital will be eligible to participate if:  The delivery takes place between 32 0/7 and 36 6/7 weeks of gestation They carry singletons  Exclusion Criteria:  Fetal anomalies including congenital malformations, anemia, and growth restriction with abnormal Dopplers. Abnormal placentation such as placenta previa. Signs of fetal distress necessitating an emergency cesarean section. Maternal health issue including severe anemia (defined as hemoglobin level < 7 g/dL), preeclampsia, and bleeding disorders. Maternal refusal of the use of blood products. General anesthesia for cesarian section. Planned cord blood banking. Total language barrier without possibility of translation - HealthyVolunteers: No - Gender: All - MinimumAge: 32 Weeks - MaximumAge: 36 Weeks - StdAgeList: Child
Hoosier Sport: Developing and Implementing a Sustainable Campus-Community Partnership in Rural Indiana
Status: Recruiting

The clinical trial aims to develop and pilot test a multilevel physical activity (PA) intervention called the Hoosier Sport program. The study follows a participatory co-design protocol involving youth, parents, and community leaders to provide direct input into the intervention's design. The ultimate goal is to contribute to health equity in the community by promoting sustainable physical activity. Hoosier Sport involves delivering enhanced physical education classes, teaching about nutrition and exercise, as well as developing leadership skills in middle school rural students.The intervention will last for 8-weeks with PE classes occur twice a week. Additionally, Hoosier Sport will create more opportunities for students to be active at school (e.g., in home room) through providing virtual classes and other activities.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Has PE class the semester during Hoosier Sport- Parent provides informed consent  Exclusion Criteria:  Answer yes to any question on the Physical Activity Readiness for Everybody (PARQ+) - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 9 Years - MaximumAge: 15 Years - StdAgeList: Child
High-intensity Versus Low-intensity Laser Acupuncture in Chronic, Non-specific Low Back Pain
Status: Not yet recruiting

The purpose of this study is to investigate the efficacy of high-intensity laser acupuncture versus low intensity laser acupuncture on peak torque of trunk extensors, fatigue of trunk extensors, back pain, ROM and function in patients with chronic nonspecific low back pain (CNLBP).

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  The patients had CNSLBP with age from 20 to 40 years from both genders. Patients will be referred from an orthopedist with diagnosis of chronic low back pain without underlying pathological causes. The patients with chronic nonspecific low back pain more than 3months. Minimum pain intensity of 30 mm on the visual analogue scale (VAS) for pain, which ranges from 0 to 100 mm. Patients with normal BMI ranges between 18.5:24.9 kg/m2. The study populations must be willing to participate in the study  Exclusion Criteria:  Neurological, infectious diseases and systemic illness such as rheumatologic diseases,systemic lupus erythematosus, diabetes mellitus type I or II. Psychiatric/mental deficit. Patients who had a previous surgical history (within 6 months) will also excluded. participation in other treatment within the previous 3 month. Pregnancy. History of spinal fracture, tumor, osteoporosis - HealthyVolunteers: No - Gender: All - MinimumAge: 20 Years - MaximumAge: 40 Years - StdAgeList: Adult
Care Choreographies and the Making of the Psychosocial in Genetic Counseling
Status: Recruiting

Background:

Genetic counselors play a new and evolving role in medical care. Recent advances in genetic testing are changing many health care treatments, and genetic counselors play a key role in teaching people how their genes may affect both health and treatments. Genetic counselors may also help guide people through complex talks about their treatment risks; their chances for recovery; and their social and emotional health and wellbeing. Researchers want to learn more about the role genetic counselors play in health care.

Objective:

To observe how genetic counselors at NIH manage the social and psychological aspects of patient care.

Eligibility:

Genetic counselors who work at NIH. People aged 18 years or older who are scheduled to meet with one of these counselors are also needed.

Design:

An investigator will sit in on the session between the counselor and the participant. The investigator will take notes. The session will not be recorded. The investigator will leave at any point if asked.

The investigator will focus on talk about social and psychological care. That person will also listen to talk about risk; diagnosis; odds of recovery; and hope, grief, and loss. That person will note strategies that help the participant manage their emotions and how they perceive their risks.

Counselors may later have a 1-hour interview with the investigator. They will answer questions about their experiences as a care provider at NIH.

Participants will have only 1 session with the investigator. Counselors may have 4 to 10 sessions with an investigator over 8 months.

Eligibility:
- EligibilityCriteria: INCLUSION CRITERIA:  To be eligible for this protocol, participants must be genetic counselors currently practicing at NIH, be a patient having a session with one of the aforementioned genetic counselors, and be at least 18 years of age. For Phase I (direct observation), we will aim to recruit genetic counselors from at least one clinical team at NIH.  For Phase II (open-ended interviews), we will recruit approximately 20 NIH staff members from those in Phase I for interviews. Potential participants for Phase II will be recruited through a purposive sampling approach, identified for their expertise in the psychological or social dimensions of clinical genetics. Potential participants will include participants in Phase I but will also include potential interviewees of interest practicing outside those who are observed in Phase I. We anticipate concluding enrollment by June 2024.  EXCLUSION CRITERIA:  Anyone who is under 18, is neither a genetic counselor (or those with whom they have genetic counseling sessions) nor allied health professional, or is unable to provide consent, will not be included in the protocol. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 115 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Genetic counselors at NIH and their respective patients. - SamplingMethod: Non-Probability Sample
Multi-Scale Analysis of Phenotypes in Heart Failure (MAP-HEART)
Status: Not yet recruiting

Background:

More than 6.5 million people in the United States live with heart failure (HF), and more than a million new cases are diagnosed each year. Treatments have improved in recent years, but researchers want to understand more about how HF develops. To do this, they need to compare blood and other samples from many people with HF.

Objective:

To collect blood and other samples from people with HF. These samples will be used to identify and study proteins and other factors that may lead to decreased heart function over time.

Eligibility:

People aged 18 years and older with heart failure.

Design:

Participants will be asked to join the study based on a review of their medical records.

They will have 1 study visit. They will provide a blood sample: About 3 tablespoons will be collected from a needle inserted into a vein.

Other tests are optional: Participants may provide urine and stool samples. They may have a cotton swab rubbed on the inside of the mouth to collect DNA.

Participants may also take 3 questionnaires. They will answer questions about dietary, social, and other factors that affect their health. Participants will receive compensation.

Researchers will follow the participants health by monitoring their medical records for up to 5 years.

Eligibility:
- EligibilityCriteria: INCLUSION CRITERIA:  In order to be eligible to participate in this study, an individual must meet all of the following criteria:  Clinical diagnosis of HF documented by a provider s note in the medical record Able and willing to undergo the consent process and provide consent Willing to comply with required study activities 18 years of age or older Male or female (or other gender-specified category)  EXCLUSION CRITERIA:  An individual who meets any of the following criteria will be excluded from participation in this study:  History of ventricular assist device History of cardiac transplant Living or residing outside of the geographic location designated for the study - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 100 Years - StdAgeList: Adult, Older Adult - StudyPopulation: We will prospectively recruit a diverse community cohort of 2000 participants with clinical HF from the District of Columbia / Maryland/Virginia metropolitan region (DMV). - SamplingMethod: Probability Sample