rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
Treatment of Fecal Incontinence and Functional Defecation Disorders Using Non-instrumental Biofeedback
Status: Recruiting

Background. Rehabilitation and re-education using instrumental anorectal biofeedback are the main treatment of anorectal functional disorders producing incontinence and outlet obstructed defecation. These treatments imply intubation of patient and several sessions of treatment leading to high consumption of resources and costs.

Hypothesis. A cognitive intervention based on original audiovisual programs developed specifically for the management of anorectal functional disorders is effective in correcting anorectal function disorders that cause fecal incontinence and evacuation disorders.

Aim. To prove In two different protocols (fecal incontinence and dyssinergic defecation) the efficacy of specifically developed non-instrumental biofeedback techniques.

Selection criteria. Patients with fecal incontinence and altered sphincter function and patients with outlet obstructed evacuation referred for biofeedback treatment.

Intervention. In separate studies (incontinence and dyssynergic defecation) patients will be randomized into biofeedback and placebo groups. One session of either biofeedback or placebo intervention will be performed at the beginning of the intervention period followed by reinforcement phone call after 2 months in incontinence and 7 days in dyssinergic defecation studies. A final visit for outcome assessment will be performed after 6 months in the incontinence study and after 4 weeks in the dyssinergic defecation study.

Biofeedback: patients will be taught to control anal and abdominal muscular activity by providing instructions using original video supports. Patients will be instructed to perform the same exercises daily at home in Schedule times.

Placebo: alternative exercises will be taught by watching commercial videos. Patients will be instructed to perform the same exercises at home following the same schedule as patients in biofeedback treatment.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Incontinence studies  Patients who have at least 4 episodes of fecal incontinence during the last 14 days. Patients able to follow instructions and attend study visits.  Dyssinergic defecation studies  Patients with constipation who present less than 3 complete spontaneous bowel movements per week and/or who have Bristol 1 or Bristol 2 type stools in more than 25% of the bowel movements in the 2 weeks prior to the study Patients able to follow instructions and attend study visits.  Exclusion Criteria:  Patients with organic digestive diseases such as inflammatory bowel disease, celiac disease, gastro-duodenal ulcer... Patients with neurological diseases (spinal cord injury, multiple sclerosis, Parkinson's disease). Patients with previous of active colon and/or rectal cancer. Patients with rectal fistula. Patients with rectal prolapse. Patients with total colectomy. Patients who have had any radiation to the pelvis in the last month. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult
Implementation of Contemporary Coronary CT Angiography in Clinical Practice
Status: Recruiting

Coronary CT angiography (CCTA) has been recognized as the first-line diagnostic test for most patients with suspected coronary syndrome, often acting as a gatekeeper for invasive coronary angiography. It is therefore pivotal to understand instances of discrepancies that are encountered in clinical practice. Moreover, most of the literature on this topic relies on obsolete machines or definitions of coronary artery stenosis that cannot be defined as severe.

The investigators aim 1) to report the real word data on the performance of last-generation CCTA in identifying obstructive coronary artery disease (also considering different thresholds of stenosis, i.e., moderate or severe) and 2) to identify predictors of discrepancies.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  CCTA with >64 rows ICA performed within one month from CCTA  Exclusion Criteria:  - age<18 years - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Real-world patients who underwent a last-generation CCTA and an ICA within one month from 2010 until 2023 - SamplingMethod: Non-Probability Sample
Effect of Cerebrolysin on the Blood Brain Barrier in Patients With Diabetes and Ischemic Stroke
Status: Recruiting

A prospective, single-center study would be carried out in the Neurology Department of the University Hospital "Dr. José Eleuterio González" in order to analyze the effect of cerebrolysin on the blood-brain-barrier in patients with ischemic stroke with personal history of type-2 diabetes

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age 18 - 80 years. Clinical and imaging criteria for ischemic stroke of the middle cerebral artery. Acute non-lacunar cerebral infarction. Cerebral infarction with a score on the NIH scale between 5 and 20 points. Patient with a previous diagnosis of type 2 diabetes mellitus, regardless of the form of diagnosis, time of evolution, previous or current treatment, adherence or not to treatment, presence or absence of microvascular and/or macrovascular complications. mRs ≤ 1 before the qualifying stroke (functionally independent for all activities of daily living). The patient and/or legal representative or direct family member has signed the informed consent form.  Exclusion Criteria:  Advanced disease or terminal with life expectancy < 6 months. - Over 80 years old Lacunar infarction or small vessel disease. Pre-existing medical, neurological, or psychiatric disease that would confound neurological or functional evaluations (eg, Alzheimer's disease, vascular dementia, Parkinson's disease, demyelinating disease, encephalopathy of any cause, history of significant alcohol or drug abuse). Pregnancy or lactation. Acute or chronic renal failure with creatinine clearance <30 mL/min. Allergy or any condition that represents a contraindication for the administration of Cerebrolysin. Treatment with another investigational drug within the past 30 days that may interfere with the study drug. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult
Improving Intrapartum Care for Saving Life at Birth in Ethiopia Through PartoMa Approach
Status: Recruiting

Overall Objective

To introduce PartoMa approach (locally agreed and achievable intrapartum guidelines and a continual in-house training program) to Ethiopian context through continuous fetal heart rate (FHR) monitoring using MOYO device and co-creation of context specific intrapartum care guideline for improving decision making in intrapartum care in Eastern Ethiopia.

Interventions

Locally agreed and achievable intrapartum guidelines
Low dose high frequency trainings (LDHF)
Partograph Overall Design

A quasi-experimental pre-post study (PartoMa study)

Setting

Department of Obstetrics and Gynaecology Haramaya Hospital and Hiwot Fana University Hospital, Ethiopia.

Population

Laboring women delivering at the study site from February 2023 to March 2025 and their offspring, as well as health providers. Women and their offspring will be enrolled at/after onset of labour and followed until discharge.

Endpoints

The primary endpoint is perinatal mortality. For further description and secondary outcomes, please see below.

Study Time

Data collection from June 2023 to May 2025.

Specific Objectives i. To assess FHR monitoring practice and use of obstetric guideline for decision making in Hiwot Fana University Hospital ii. To improve feto-maternal outcome through applying PartoMa approach in Hiwot Fana University Hospital.

iii. To determine the feasibility, acceptability and sustainability of low-dose high frequency trainings and PartoMa seminars in Hiwot Fana University Hospital.

iv. To document changes in pregnancy outcomes after the introduction of PartoMa approaches-seminars, low dose high frequency trainings, continuous FHR monitoring and tailored interventions-in Hiwot Fana University Hospital.

Setting

PartoMa Ethiopia will be implemented at Haramaya General Hospital and Hiwot Fana Comprehensive Specialized University Hospital, which are both busy maternity units in Eastern Ethiopia. Both are government hospitals with an annual delivery number of around 5,000.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  All women in labour delivering at the study site and their outcome, July - September 2023 and July -September 2025 All birth attendant at the study site in obstetrics and gynecology departments during the baseline and intervention period, July - September 2023 and July -September 2025  Exclusion Criteria:  NA - HealthyVolunteers: No - Gender: Female - MinimumAge: 18 Years - MaximumAge: 50 Years - StdAgeList: Adult
Swab Testing to Optimize Pneumonia Treatment With Empiric Vancomycin
Status: Not yet recruiting

This is a single center, pragmatic, randomized clinical trial (pRCT) examining whether reporting the results of a negative rapid PCR back to the provider via a pager alert results in decreased vancomycin utilization for critically ill adults with community-acquired pneumonia when compared with usual care.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Adult (age greater than or equal to 18) patients admitted/transferred to the Vanderbilt University Medical Center (VUMC) Medical Intensive Care Unit (MICU) from the VUMC Emergency Department or from a hospital floor within 48 hours of admission. Suspicion for pneumonia on admission (defined as an indication for antibiotics of "respiratory infection" and/or an order for a respiratory culture i.e., sputum culture, tracheal aspirate culture, or bronchoalveolar lavage (BAL) culture). No topical nasal decolonization during hospitalization prior to collection of MRSA nasal swab PCR.  Must match both of the following in either order:  The patient has been admitted to and physically located in the MICU. The patient has received a continuing vancomycin order, or a pharmacokinetics consult for a continuing vancomycin order, no later than 24 hours following their physical admission to the MICU.  Exclusion Criteria:  Hospital stay of longer than 48 hours prior to MICU admission. Known to be a prisoner - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Predicting Cognition After DBS for Parkinson's Disease 2
Status: Not yet recruiting

The aim of the study is to improve estimation of cognitive outcome after STN-DBS in PD in order to avoid risk factors by optimizing peri- and intraoperative management personalize therapeutic strategies for optimal long-term benefit.

The investigators will test possible predictors (clinical, neuropsychological, neuroimaging, electrophysiological and molecular) for the risk of cognitive dysfunction after deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson's disease (PD) at a single center (Charité - Universitätsmedizin Berlin, Germany). Data collection takes place prior to as well as 3, 12 and 60 months after the STN-DBS operation. Participation is proposed to all PD patients that are planned to undergo STN-DBS after careful examination of eligibility for this treatment according to standard operation procedures.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Diagnosis of idiopathic Parkinson's Disease Indication for STN-DBS  Exclusion Criteria:  Internistic, surgical or psychiatric contrainidications with respect to the DBS operation or treatment for the STN-DBS group Dementia Relevant language barrier - HealthyVolunteers: No - Gender: All - GenderBased: Yes - MinimumAge: 18 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult - StudyPopulation: PD patients that are planned to undergo STN-DBS. - SamplingMethod: Non-Probability Sample
An Observational Study to Identify New Health Problems Arising After an Intensive Care Unit Admission in People With Acute Respiratory Distress Syndrome in the United States
Status: Not yet recruiting

This is an observational study in which data already collected from people with acute respiratory distress syndrome (ARDS) admitted to an intensive care unit (ICU) are studied.

ARDS is a life-threatening condition in which fluid builds up in the lungs making breathing difficult.

In observational studies, only observations are made without participants receiving any advice or any changes to health care.

People who are admitted to ICU for serious illnesses, like ARDS, often experience new health problems during and after their ICU stays. These health problems that may include physical, mental, and/or emotional disorders, are called post-intensive care syndrome (PICS). Identifying these new health problems early can help people by timely treatments and care.

In this study, researchers want to identify any health problems that arise after ICU admission in people with ARDS in the United States (US). To do this, researchers will collect information on health problems, treatments, medicines, and healthcare visits in people with ARDS, 1 year before and after an ICU admission.

They will then look to see whether the health problems are in areas that have been described as the post intensive care syndrome (PICS).

In addition, they will measure healthcare related costs in the one year after admission and compare it to the one year prior to admission.

Researchers will also compare this information with data collected for people with pneumonia who did not require ICU admission. This will help them to identify any new health problems arising due to ICU stays.

The data will come from participants' medical claims information stored in the Optum Clinformatics Data Mart database from 2016 to 2022. The claims data will only be collected for people in the US.

Researchers will collect data from participants admitted to ICU for ARDS for a maximum of 1 year before and after their stay.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  continuous coverage of at least 365 days (>= 1 year) pre-index date for the cohort age >= 18 years not seen outside the healthcare system  Exclusion Criteria:  none - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: All adult patients in Optum Claims data with acute respiratory distress syndrome (ARDS) admitted to an intensive care unit (ICU) from January 1, 2016 until October 1, 2022. - SamplingMethod: Non-Probability Sample
Serum Elafin and Vascular Affection in Behcet Disease
Status: Not yet recruiting

To measure the level of serum elafin in patients with BD. To assess the relation between serum elafin levels and disease activity. To evaluate the vascular complications in BD and determine their relationship with disease activity.

To assess the correlation between serum elafin and vascular affection and their relation with disease activity.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients diagnosed as BD. Age of all participants (20-45) years.  Exclusion Criteria:  Age <20 or >45 years. Other autoimmune diseases. Cardiovascular diseases (heart failure, myocardial ischemia). Possible related risk factors (e.g. diabetes, dyslipidemia, smoking). chronic conditions (e.g. chronic kidney disease, malignancy, autoimmune diseases). - Gender: All - MinimumAge: 20 Years - MaximumAge: 45 Years - StdAgeList: Adult - StudyPopulation: Patients diagnosed as BD. Age of all participants (20-45) years. - SamplingMethod: Non-Probability Sample
Comparison of the Effect of Aminophylline, Magnesium Sulphate and Placebo in Prevention of Post Dural Puncture Headache in Parturient Undergoing Caesarean Section.
Status: Not yet recruiting

This study will be conducted to better comprehend the effect of aminophylline in comparison to magnesium sulphate on preventing and/or treating PDPH.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  All parturient who underwent cesarean section under spinal anesthesia. Patients who are willing to participate in the trial gave an informed consent. ASA physical status II. The age ranged from 20 to 40. Body Mass Index (BMI) ranged from 25 to 30 kg/m2.  Exclusion Criteria:  Patient refusal. Allergy to the studied drugs. Patients with contraindications to spinal anesthesia. Those with past history of chronic headache or recent onset of acute headache were excluded. Women who had multiple punctures (>2) during the spinal anesthesia procedure were excluded from the study. Patients with advanced decompensated cardiac, renal, hepatic disease. - Gender: Female - GenderBased: Yes - MinimumAge: 18 Years - MaximumAge: 35 Years - StdAgeList: Adult - StudyPopulation: All parturient who underwent cesarean section under spinal anesthesia.  Patients who are willing to participate in the trial gave an informed consent. ASA physical status II. The age ranged from 20 to 40. Body Mass Index (BMI) ranged from 25 to 30 kg/m2. - SamplingMethod: Non-Probability Sample
Effect of Benzocaine 20% Topical Anesthesia on Pain Levels When Placing Separators in Children Receiving Hall Technique Crowns
Status: Not yet recruiting

The goal of this RCT is to investigate the immediate effect of benzocaine 20% topical anesthesia on initial pain and discomfort levels associated with the placement of elastomeric orthodontic separators in children who are receiving Hall Technique crowns on primary molars, among children who have attended the Pediatric Dentistry Department, Dubai Dental Hospital (DDH), Mohammed Bin Rashid University (MBRU) in Dubai, the United Arab Emirates (UAE).

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Children with asymptomatic non pulpally involved carious primary molars who meet the indications of the HT in Dubai Dental Hospital. Children who require same tooth bilateral HT Crowns in either bilateral or diagonal pattern. Healthy male and female children, aged 4-10 years (ASA 1) with no conditions that affect sensory input/reaction. Children who are verbal and able to communicate. Not taking any painkillers, or other drugs that would influence with their pain perception. Cooperative children. Parents or guardians who consent for their children to be enrolled in the trial.  Exclusion Criteria:  Children who are indicated for bilateral HT but do not require EOS, due to pre-existing interdental spaces. Children who are indicated for bilateral HT but parents prefer or indicate preference for the Modified HT. Children with allergies to nickel or other metal components that constitute a PMC. Those with reported allergies to topical or local anesthetic. Children with special health care needs or those who are non-verbal and are unable to communicate their pain levels. Children/parents/guardians not willing to participate in the study. Patients that require treatment under conscious sedation or general anesthesia. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 4 Years - MaximumAge: 10 Years - StdAgeList: Child
THE EFFECT OF MOTIVATIONAL INTERVIEWING ON NURSING STUDENTS WITH SOCIAL ANXIETY
Status: Not yet recruiting

Studies support the idea that people diagnosed with social anxiety disorder score significantly lower on self-acceptance than healthy controls, and that self-compassion is inversely related to anxiety. Motivational interviewing has been shown to improve treatment outcomes as well as predict higher self-compassion and reduced resistance among participants.It also has the ability to increase the effectiveness of motivational interviewing as an intervention with perpetrators of intimate partner violence, promoting readiness for change and progression through stages of change. In this context, this study aims to examine the effect of motivational interviewing on social anxiety level, dating violence and self-compassion in nursing students with social anxiety.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Having moderate or marked social anxiety (55-80 points on the LSCQ) Volunteering to participate in the research Being in the pre-intention and intention stage according to the stage of change assessment form  Exclusion Criteria:  Having no or low, severe or very severe level of social anxiety (score of 54 and below and 81 and above on the LSCQ) Having any psychiatric diagnosis Having received psychotherapy for social anxiety before Attending a psychotherapy or counseling program - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 25 Years - StdAgeList: Adult
Fluidotherapy in Patients With Distal Radius Fractures
Status: Recruiting

Distal radius fractures are the most common fractures when looking at upper extremity fractures. The incidence of distal radius fractures is increasing day by day, and when looking at the databases of various countries, its annual prevalence reaches 70,000 in the UK and 640,000 in the USA. Most of these fractures are related to osteoporosis and require appropriate treatment. If not, it causes loss of work force, permanent disability, and limitation in daily activities.

Fluidotherapy has also proven to be effective in reducing hand edema in patients with carpal tunnel syndrome and stroke, examining its effect on nerve conduction velocities, and warming hypothermic patients. Compared to these treatment methods, fluid therapy reduces both joint capsule and muscle temperature by 9°C and 5.7°C, respectively. has been reported to increase.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  -Treating with a cast due to distal radius fracture being over 18 years old  Exclusion Criteria:  Presence of polytrauma History of previous limb-related surgery Hemiplegia in the involved limb Contracture in the involved limb Arterial and venous occlusions Lymphatic system disorders Heart and circulatory system disorders Hepatitis, Measles, Sepsis infectious diseases or fever Open wound on the applied hand. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 85 Years - StdAgeList: Adult, Older Adult
BostonGene and Exigent Genomic INsight Study
Status: Not yet recruiting

The BEGIN Study by BostonGene and Exigent Genomic INsight evaluates the efficacy of comprehensive molecular testing in advanced cancer patients. Using the BostonGene Tumor Portrait test, the study aims to identify actionable findings, assess feasibility, and determine patient enrollment in clinical trials. Four cohorts of 100 patients each will be studied over two years, focusing on treatment decisions and patient outcomes. This study seeks to demonstrate the clinical utility of genomic testing in guiding therapy for advanced cancer patients in community settings.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients must have a confirmed malignancy of:  Locally recurrent, unresectable, or metastatic breast cancer or; Unresectable stage III or metastatic non-small cell lung cancer or; Unresectable or metastatic melanoma or; Locally advanced or metastatic l sarcoma.  Life expectancy > 3 months as per the treating physician Willingness to provide informed consent Living in the United States at time of enrollment Agree to participate in genomic and molecular profiling  Exclusion Criteria:  not meeting the inclusion criteria - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Advanced cancer patients - SamplingMethod: Probability Sample