rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
Hip Activation vs. Hip Activation + Core Stabilization
Status: Recruiting

The purpose of this investigation is to compare the effects of a combined hip activation and core stabilization training home exercise program (HEP) versus a hip activation training HEP alone on lower extremity (LE) frontal plane mechanics in healthy individuals.

Specific Aim 1: To determine whether between- and/or within-group differences exist on the Forward Step-Down test (FSDT) when comparing a combined hip activation and core stabilization training HEP as compared to a hip activation training HEP.

Specific Aim 2: To determine whether between- and/or within-group differences exist on the peak external knee abduction moment when comparing a combined hip activation and core stabilization training HEP to a hip activation training HEP.

Specific Aim 3: To determine whether between- and/or within-group differences exist on gluteal and core muscle surface electromyography (sEMG) when comparing a combined hip activation and core stabilization training HEP to a hip activation training HEP.

Specific Aim 4: To determine whether a dose-response relationship exists between HEP compliance and change on the FSDT, peak external knee abduction moment, and sEMG.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Participants will be current first- or second-year Doctor of Physical Therapy (DPT) students in the School of Allied Health Professions (SAHP) at Louisiana State University Health Shreveport over the age of 21.  Exclusion Criteria:  Current pain or pathology in either LE which currently limits their ability to perform the FSDT or drop landing task, a history of low back pain in the last three months, known pregnancy, as pregnancy is a risk factor for diastasis rectus abdominis (DRA) which may be exacerbated by participation in the intervention and could be a confounding variable, and current participation in other clinical trials. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 22 Years - StdAgeList: Adult, Older Adult
Chronic Sleep Deprivation and Changes in Cortical and Hippocampal Volume
Status: Not yet recruiting

Sleep is a physiological state that is essential for human performance, including academic, occupational, interpersonal, and psychological aspects. Sleep disruption or deprivation leads to a loss of psychomotor skills and an increased association with various diseases. Therefore, it is critical to assess how chronic sleep deprivation affects medical residents who work long shifts, including those assigned during their training.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  New resident physicians assigned to the High Specialty Medical Unit, Hospital de Especialidades No. 1 Centro Médico Nacional Del Bajío.  Exclusion Criteria:  - Patients who have ingested caffeine, nicotine or alcohol in the last 24 hours. Patients with sleep disorders who present a score greater than 5 in the initial assessment of the Pittsburgh Sleep Quality Index. Patients with psychiatric treatment. Patients ingesting medications that intervene in the awake state. Patients with drug abuse (marijuana, cocaine, etc.). Patients with claustrophobia. Patients with metallic implants. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 24 Years - MaximumAge: 30 Years - StdAgeList: Adult - StudyPopulation: All first-year medical residents admitted to our hospital unit who meet the inclusion criteria will be informed of the purpose of the study and, after signing the informed consent, will undergo cranial magnetic resonance imaging. - SamplingMethod: Non-Probability Sample
A Phase 1b Proof-of-concept Trial Exploring the Effects of FE 999322 and FE 999324 in Adults With Mild to Moderate Ulcerative Colitis
Status: Not yet recruiting

To explore the safety of FE 999322 (microbiota suspension) and FE 999324 (microbiota capsule) versus placebo in subjects with active mild to moderate ulcerative colitis (UC).

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Subject aged ≥18 at screening Established diagnosis of ulcerative colitis by standard clinical, endoscopic and histological criteria, for more than 3 months at screening  Exclusion Criteria:  Active disease or history of Crohn's disease Active disease or history of irritable bowel syndrome (IBS) or any other chronic intestinal disease apart from UC Active gastrointestinal infection. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Effects of Railway Vibration on Sleep and Disease
Status: Recruiting

This study will investigate the biological mechanisms linking sleep disruption by vibration and noise, and the development of cardiometabolic disease. In a laboratory sleep study, the investigators will play railway vibration of different levels during the night. The investigators will also measure objective sleep quality and quantity, cognitive performance across multiple domains, self-reported sleep and wellbeing outcomes, and blood samples. Blood samples will be analyzed to identify metabolic changes and indicators of diabetes risk in different nights. Identifying biomarkers that are impacted by sleep fragmentation will establish the currently unclear pathways by which railway vibration exposure at night can lead to the development of diseases in the long term, especially metabolic disorders including diabetes.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  1) live in or around the city of Gothenburg area (Sweden)  Exclusion Criteria:  aged <18 or >30 years; habitual sleep and wake timings more than ±1 hour different from the study sleep times (i.e. habitual sleep time should be 22:00-00:00 and habitual wake time should be 06:00-08:00); BMI>25 kg/m2; regular sleep medication use (prescribed or "over-the-counter"); poor hearing acuity (measured during screening via pure tone audiometry); diagnosed with sleep disorders; diagnosed with diabetes indications of sleep apnea on the STOP-BANG questionnaire; shift work; smoking, vaping, snus, or other nicotine use; pregnant or breastfeeding - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 30 Years - StdAgeList: Adult
Gain in Stretched Penile Length After Phalloplasty With & Without Penile Traction in Children.
Status: Recruiting

The goal of this Randomized Controlled Trial is to assess the gain in stretched penile length after phalloplasty with & without penile traction in children of age group 4 to 13 years presenting in hospital with the complaint of concealed penis.

The main question[s] it aims to answer is:

• Gain in stretched penile length after phalloplasty with and without penile traction in children.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Infants and children aged 4 years to 13 years of age. Presenting with concealed penis for circumcision.  Exclusion Criteria:  Congenital Buried Penis Webbed penis Structural abnormalities of the penis such as hypospadias, Epispadias etc. Existing co-morbid syndromes or conditions Unfit for general anesthesia Known bleeding diathesis Incomplete foreskin Any previous penile surgery - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Male - GenderBased: Yes - GenderDescription: Male - MinimumAge: 4 Years - MaximumAge: 13 Years - StdAgeList: Child
HOme-Based Self-management and COgnitive Training CHanges Lives (HOBSCOTCH)-Parkinson's Disease (HOBSCOTCH-Parkinson's)
Status: Recruiting

The goal of this pilot study is to assess the feasibility of adapting and delivering the existing home-based epilepsy self-management intervention, HOBSCOTCH, for people with Parkinson's Disease (PD)

The main questions it aims to answer are:

Can the current HOBSCOTCH program be adapted for people with PD?
Will people with PD experience improved quality of life similar to that found in people with epilepsy after participating in the HOBSCOTCH program?

Participants will be asked to:

attend nine, one-hour virtual (online and/or by telephone) HOBSCOTCH-PD sessions with a one-on-one certified HOBSCOTCH-PD coach
complete a brief clinical questionnaire about their diagnosis of PD
complete two questionnaires before and after the HOBSCOTCH-PD sessions about their quality of life and about memory and thinking processes
keep a short daily diary about their PD symptoms and use of the self-management strategies taught in the HOBSCOTCH-PD program
complete a brief Satisfaction Survey after the entire HOBSCOTCH-PD program

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age 30 - 75 years Diagnosis of Parkinson's Disease per participant's provider Literate, English-speaking with grade 12 or equivalent in education Self-reported cognitive/memory difficulties Telephone and internet access  Exclusion Criteria:  Cognitive dysfunction that precludes participation in giving informed consent Significant visual impairment precluding reading or writing No reliable telephone or internet access - HealthyVolunteers: No - Gender: All - MinimumAge: 30 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult
Recovery Kinetics Following a Soccer Training in Middle-aged Males
Status: Recruiting

This study aims at investigating the recovery kinetics of skeletal muscle damage, neuromuscular fatigue and performance following a single soccer trainning session in middle aged males. The participants will perform a soccer training session [A single training session including 60 minutes of warm up, soccer technical exercises and small-sided game] and a cotrol trial (No intervention included, only daily measurements) in randomized, repeated measures, crossover design. Assesesments related to skeletal muscle damage, performance and neuromuscular fatigue will be executed before the training session and daily for four consecutive days after training.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Free of musculoskeletal injuries No use of ergogenic supplements or medication Free of chronic diseases age of 40-60 years  Exclusion Criteria:  Musculoskeletal injury Use of alcohol, caffeine and any type of ergogenic supplements or medication during the course of the study - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Male - MinimumAge: 40 Years - MaximumAge: 60 Years - StdAgeList: Adult
Nutrition Under Noninvasive Ventilation
Status: Not yet recruiting

Even though nutrition is a fundamental component of Intensive care unit (ICU) therapy, critically ill patients are frequently malnourished, a factor well known for its strong association with a higher risk of complications, prolonged ICU/hospital length of stay, and greater ICU readmission and mortality rates. Noninvasive ventilation (NIV) use has increased considerably over the past twenty years, making this supportive technique a keystone of acute respiratory failure (ARF) treatment. In this setting, respiratory support is provided through an interface, usually a mask or a helmet, that frequently represents an important obstacle to nutrition delivery, making oral intake impossible and posing the necessity to start enteral (EN) or parenteral nutrition (PN). Moreover, while critical care guidelines regarding nutritional management of patients receiving mechanical ventilation (MV) are well established, data and recommendations about the appropriate nutritional support to patients in NIV are still very limited. Due to this limited data, we want to describe characteristics and nutritional management of patients undergoing NIV in ICU, and to evaluate the difference between the mean caloric and protein intake of these patients and the recommended caloric and protein target for critically ill patients. Secondarily, we want to evaluate the difference of the caloric and protein intake among groups of patients undergoing different nutritional modality and to assess potential associations of the nutritional characteristics with patient outcomes.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Adult patients; Admission to the Intensive Care Unit of Maggiore della Carità University Hospital from March 1st 2020 to February 28th 2023; Noninvasive ventilation treatment for acute respiratory failure of any cause; Duration of noninvasive ventilation treatment of more than two days; Informed consent signed.  Exclusion Criteria:  Patients under 18 years of age; Duration of noninvasive ventilation treatment of less than two days. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Adult patients admitted to the Intensive Care Unit of Maggiore della Carità University Hospital from March 1st 2020 to February 28th 2023, undergoing noninvasive ventilation for any diagnosis of acute respiratory failure and for any cause (to avoid endotracheal intubation, as alternative to invasive ventilation, as weaning from invasive ventilation) will be considered. - SamplingMethod: Non-Probability Sample
Assessment Of Serum And Tissue Levels Of Cold-Inducible RNA-Binding Protein In Patients With Lichen Planus
Status: Recruiting

Lichen planus (LP) is a chronic inflammatory mucocutaneous disease of unknown etiology.

Pathogenesis of LP is not completely understood, but it's considered a T-cell-mediated autoimmune disease. Cold-inducible RNA binding protein (CIRP or CIRBP) is a member of the glycine-rich RNA-binding protein family, Recent studies proved that CIRP acts as a tumor promoter through its actions on different cellular proliferation levels, Recently, the role of the damage associated molecular proteins and cytokines was highlighted in the pathogenesis of many disorders including psoriasis, alopecia areata, vitiligo, rheumatoid arthritis, other autoimmune diseases as well as several types of cancer. The aim of this study is to compare serum and tissue levels of CIRP in patients with LP and healthy controls.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients from both sexes aged 18 - 60 years, having clinical and dermoscopic confirmed LP and did not receive any topical or systemic treatment in the last 3 months for LP.  Exclusion Criteria:  1 . Pregnancy and lactation. 2. Patients with any infections or sepsis. 3. Patients with any other dermatological diseases associated with increased CIRP levels (eg. psoriasis, vitiligo or alopecia areata).  4. Patients with systemic illness (cardiac, renal, hepatic or respiratory), malignancy, with history of connective tissue diseases or on immunosuppressive treatment.  5. Patients who received any topical or systemic treatment for LP 3 months before the study.  6. Patients with oral, nail or scalp LP. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 60 Years - StdAgeList: Adult - StudyPopulation: 40 patients with LP and 40 age and gender matched healthy controls who will attend the Dermatology Outpatient Clinics, Sohag University Hospitals. Diagnosis of LP will be clinically and will be confirmed by dermoscopy. - SamplingMethod: Probability Sample
A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis
Status: Recruiting

The purpose of this study is to evaluate the efficacy of guselkumab in pediatric participants with moderately to severely active ulcerative colitis at the end of maintenance therapy among participants who were induction responders.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Weight greater than or equal to (>=) 10 kilogram (kg) at the time of consent for screening A pathology report to support a documented diagnosis of Ulcerative Colitis (UC) must be available in the source documents. There is no maximum duration for which a participant needs to be diagnosed with UC. If the pathology report to support a documented diagnosis of UC is not available in the source documents, the screening endoscopy with biopsies (obtained within 3 weeks before first study intervention administration) needs to support the diagnosis of UC. Moderately to severely active UC, defined by a baseline modified Mayo (without physician's global assessment) score of 5 through 9 inclusive, with a screening Mayo endoscopy subscore >= 2 as determined by a central review of the video of the endoscopy, and a baseline Mayo rectal bleeding subscore >=1 Medically stable on the basis of physical examination, medical history, and vital signs, performed at screening. Any abnormalities must be consistent with the underlying illness in the study population and this determination must be recorded in the participant's source documents and acknowledged by the investigator Participants must have had an inadequate response and/or intolerance to biologic therapy and/or conventional therapies or be dependent upon corticosteroids  Exclusion Criteria:  Have UC limited to the rectum only or to less than (<) 20 centimeter of the colon Presence of a stoma Has had any kind of bowel resection within 6 months or any other intra-abdominal surgery within 3 months of baseline Have severe colitis or have evidence of Crohn's Disease (CD) - HealthyVolunteers: No - Gender: All - MinimumAge: 2 Years - MaximumAge: 17 Years - StdAgeList: Child
Acute Physiological Effects of Greek Traditional Dancing
Status: Not yet recruiting

In Greece, people of different age groups, including young children to older adults, are involved in traditional dance. To date, the well-know benefits of dancing include entertainment, socialization and increased physical activity. However, the acute effects of Greek traditional dancing on health, physical performance and muscle damage indices remain largely unknown. Therefore, the aim of this project is to evaluate the acute effect of Greek traditional dancing on health-, physical performance-, and muscle damage-related parameters by considering the impact of dancing tempo (slow vs moderate vs fast). In a crossover repeated measures design 10 pre- and 10 post-menopausal women will participate in the three dancing sessions of different tempo in a random order.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Premenopausal and postmenopausal women. Abstain from vigorous physical activity and/or exercise during the last (at least) 6 months prior to the study. Free of musculoskeletal diseases and injuries. Free of cardiometabolic diseases. Free of mental health disorders No body weight loss >10% over the last 6 months prior to the study Non-smokers  Exclusion Criteria:  Perimenopause and menopause women Participation vigorous physical activity and/or exercise during the last (at least) 6 months prior to the study Presence of musculoskeletal diseases and injuries. Presence of cardiometabolic diseases. Presence of mental health disorders Body weight loss >10% over the last 6 months prior to the study Smokers - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - GenderBased: Yes - GenderDescription: Healthy pre-menopausal and post-menopausal women - MinimumAge: 20 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult
Photobiomodulation for Oral Mucositis and Functional Impairments During Hematopoietic Stem Cell Transplantation
Status: Not yet recruiting

The goal of this clinical trial is to test the efficacy of laser photobiomodulation in adult hematologic cancer patients undergoing hematopoietic stem cell transplantation (HSCT). The main questions it aims to answer are: • Is photobiomodulation with laser in the oral cavity, compared to standard care, effective in preventing oral mucositis and functional impairments in adult patients receiving HSCT? • What is the level of patient´s acceptability of photobiomodulation with laser in the oral cavity during HSCT? Participants once a day will receive photobiomodulation (diode laser device) in their oral cavity from the first day of transplantation conditioning until third day post-transplant. Researchers will compare with usual care to see if photobiomodulation helps preventing oral mucositis and functional impairment.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Adults over 18 years of age with hematological neoplasms who require medical indication of an HSCT according to the Transplant Committee at Clinica Dávila With sufficient understanding of Spanish.  Exclusion Criteria:  Observed cognitive deficit Patients who do not meet the criteria of clinical stability, progression of the disease, and that do not fulfill requirement of the National Hematopoietic Stem Cell Transplantation Program. Participants with an oral infection from any type of Candida prior to HSCT. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 70 Years - StdAgeList: Adult, Older Adult
StressLess Yoga Study
Status: Recruiting

The purpose of this study is to assess the feasibility and acceptability of using an asynchronous online yoga program to reduce stress. The study will use an 8 week asynchronous yoga intervention of two different types of yoga (high in breath work and meditation; low in vigorous movement/postures vs. low breath work and meditation; high movement/postures). In addition to self-report stress, measures include sleep, heart rate variability, mindfulness, Essential Properties of Yoga, and acceptability questions.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Aged 18 years or older Self-identification as "stressed" Scoring 8 or higher on the Perceived Stress Scale (PSS) indicating moderate-to-high stress Willingness to complete the 8-week yoga intervention Willingness to attend baseline and follow-up visits Ability to read and write in English Having practiced yoga ≤ 2x in the last 6 months  Exclusion Criteria:  Serious or unstable psychiatric illness (e.g., psychosis, mania) Major coexisting medical illness (e.g., cancer, COPD, obesity) - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Magnesium and Riboflavin Treatment for Post-Concussion Headache
Status: Recruiting

This clinical trial will try to determine if the supplements magnesium and riboflavin will reduce the pain and duration of headaches in persons diagnosed with a concussion. The participant will be randomized to either active magnesium and riboflavin capsules or placebo (inert) capsules. The capsules will be taken once a day for 14 days. The participant will also complete a short diary form for the 14 days and will have 3 follow up visits either by telephone or in person.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Seen at University of Virginia Student Health and Wellness Center or Emergency Department for Initial Visit for Concussion; Less than 3 days have elapsed since their injury; Able to swallow capsules  Exclusion Criteria:  Concussion complicated by cranial bleed, skull fracture, additional severe injury; Kidney disfunction or failure; Significant gastro-intestinal dysfunction; Varsity Athlete; Two or more previous concussions; Women who are pregnant or breast feeding; Taking tetracycline, fluoroquinolone, iron digoxin, chlorpromazine or penicillamine - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 40 Years - StdAgeList: Adult