rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
Medical Thoracoscopy for Diagnosing Unexplained Pleural Effusion: a National Multicenter Retrospective Study
Status: Not yet recruiting

This study is a national multicenter retrospective study. Patients with unexplained pleural effusion who underwent thoracoscopic or video-assisted thoracoscopic biopsy for patients in recent 10 years were retrospectively collected from multiple centers to understand the proportion and final etiological composition of pleural effusion in China.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients with unexplained pleural effusion who underwent thoracoscopic or video-assisted thoracoscopic biopsy  Exclusion Criteria:  Patients who cannot obtain a final diagnosis - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Patients with pleural effusion who underwent medical thoracoscopy were included in the study. Patients who could not obtain a final diagnosis were excluded from the study - SamplingMethod: Non-Probability Sample
The Effects of Acupressure on Improving Postoperative Gastrointestinal Symptom Distress in Esophageal Cancer Patients
Status: Not yet recruiting

This study is a quasi-experimental design clinical trial with the primary objective of comparing the health status of patients with esophageal cancer. Participants were divided into an experimental group and a control group. Patients in the experimental group received routine care and acupressure for 5 consecutive days starting from the day after entering the ward after esophageal cancer surgery, in the control group, participants received routine care, and Participants were assessed on the Gastrointestinal Symptom Distress Scale at the end of the intervention. The aim of this study was to verify the effectiveness of acupressure in improving of gastrointestinal symptoms distress after esophageal cancer surgery.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Hospitalized men and women who agree to participate in this study Patients diagnosed with esophageal cancer based on pathological tissue section results Nutritional support through jejunostomy in post esophagectomy patients A sufficient level of education to understand study procedures and be able to communicate with site personnel  Exclusion Criteria:  Pregnant or lactating women Diagnosed and treated for peripheral vascular disease within 3 months prior to surgery. Those with unstable vital signs and septicemia infection after surgery. Those who are suffering from blood diseases with abnormal coagulation function, or Currently taking anticoagulant drugs. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 85 Years - StdAgeList: Adult, Older Adult
Integrated Assessment of Cervicocerebral Vessels to Improve the Brain Injury for CAGB Patients (IACV Study)
Status: Recruiting

The goal of this study is to establish a prospective study to focus on the high-risk stroke population who require coronary artery bypass graft surgery. It will divide the eligible patients into 1:1 group by simple randomization method. The control group adopt the traditional diagnosis and treatment mode, and only head CT plain scan and carotid artery ultrasound shall be performed. If necessary, relevant disciplines would be consulted but no integrated assessment of cervicocerebral vessels be arranged. The final treatment plan would be decided by the surgeon alone. The experimental group adopt the multidisciplinary collaboration and integrated evaluation mode. In addition to routine diagnosis and treatment as above-mentioned, integrated assessment of cervicocerebral vessels shall be performed, including transcranial color-coded doppler, cerebral perfusion with multislice CT, and cognitive function assessment. Based on the above results, surgical plans will be formulated jointly by multiple disciplines including neurologists, vascular surgeons, ICU physicians and cardiac surgeons. Researchers will compare the two groups to investigate whether integrated assessment of cervicocerebral vessels can reduce the incidence of brain injury compared with conventional diagnosis and treatment mode.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients who require CABG surgery; Age ≥18 years with a history of stroke or transient ischemic attack; Combined with typical symptoms of stroke; Previous imaging findings suggest a high risk of stroke  Exclusion Criteria:  < 18 years old; > 80 years old; Combined with congenital cerebrovascular malformation; Emergency operation; Reluctant to sign an informed consent form; Reluctant to follow up - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult
Optimizing Surgical Decisions in Young Adults With Breast Cancer
Status: Not yet recruiting

The goal of this study is to understand and improve the breast surgical decision-making process for young women newly diagnosed with breast cancer. As part of this study, the investigators will evaluate the impact and use a web-based tool called CONSYDER that is designed to provide useful information to young breast cancer patients. It is also meant to improve communication between young women and their surgeons with the purpose of helping patients make appropriate surgical decisions.

Participants will complete surveys within 1 week of the surgical consult and 6 months after surgery. Patients who receive neoadjuvant chemotherapy will also be surveyed after the completion of neoadjuvant treatment but prior to surgery. Some patients will be invited for an interview after their surgery as part of the evaluation. A subset of patients/surgeons will also have their surgical consultation audio-recorded.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Female aged 18-44 New diagnosis of Stage 0, 1, 2, or 3 unilateral breast cancer English or Spanish speaking  Exclusion Criteria:  Diagnosis of de novo Stage 4 breast cancer Recurrent early-stage breast cancer Bilateral breast cancer - HealthyVolunteers: No - Gender: Female - MinimumAge: 18 Years - MaximumAge: 44 Years - StdAgeList: Adult
BRING-UP Prevention
Status: Recruiting

The aim of this observational study is to assess in patients with a documented athero-thrombotic event: coronary artery disease (CAD), cerebrovascular disease (CVD), peripheral artery disease (PAD):

the level of adherence to guideline recommendations with the assumption to improve the rate of patients at goal for cholesterol levels.
the level of adherence to guideline recommendations and the rate of patients at goal for the other relevant and modifiable risk factors for cardiovascular event recurrence.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Both sexes at birth, age ≥18 years  At least one of the following clinical conditions:  Documented CAD defined as:  Prior Acute Coronary Syndrom (ACS) Prior Coronary Artery Bypass Graft (CABG) Prior Percutaneous Coronary Intervention (PCI) Documented PAD (previous peripheral bypass surgery or angioplasty, limb or foot amputation, intermittent claudication with objective evidence of peripheral artery disease, Ankle Brachial Index (ABI)<90). Documented CVD: Ischemic stroke, previous carotid vascular interventions. Signed informed consent.  Exclusion Criteria:  Active neoplasia or very severe disease compromising short-medium term life expectancy. Participation in interventional studies. Patients already enrolled into the study from another participating center or in the previous enrolling phase. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Patients discharged (after ordinary hospitalisation or day hospital) or managed as outpatients with a documented prior athero-thrombotic event: coronary artery disease (CAD), cerebrovascular disease (CVD), peripheral artery disease (PAD). - SamplingMethod: Non-Probability Sample
PREhabilitation in Patients Awaiting Acute Inpatient Cardiac SurgEry
Status: Not yet recruiting

This is a single centre, single arm pilot feasibility study to determine the feasibility and practicality of prehabilitation in acute inpatients waiting for cardiac surgery. We will be looking into participant eligibility, acceptability, recruitment rates, completion rates and barriers to implementing a prehabilitation programme. Secondary outcomes include safety (incidence of adverse events directly related to the study), improvement in 6 minutes walk test (6MWT), hand grip strength, quality of life, and spirometry. At the end of the trial, we will be seeking the feedback of the participants to help us improve the design further.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  All patients over the age of 18 scheduled for acute cardiac surgery in CHH will be given consideration to participate in this clinical trial.  Exclusion Criteria:  Patients who are unable or unwilling to participate in any of the elements of prehabilitation will be excluded. These include those that have cognitive disability (including unconsciousness), cardiac or clinical instability, functional or anatomical impairment which impairs ability to participate, language barrier or patient refusal. Patients that have impending surgery within 72 hours of arrival to hospital will be excluded. Patients who are awaiting surgery in district hospitals or outside of Castle Hill Hospital will be excluded. A non-exhaustive list of exclusion criteria is included below.  Cardiac/ clinical instability such as:  Recurrent unstable angina/ crescendo angina Untreated decompensated heart failure Malignant arrhythmias awaiting treatment Resting tachycardia (HR>100 bpm) Left ventricular outflow obstruction such as Aortic Stenosis with pre-syncopal or syncopal symptoms Unresolved acute pericarditis or myocarditis Second or third degree heart block without pacemaker Aortic Dissection Myxoma  Functional/ anatomical impairment such as:  Severe musculoskeletal conditions that would prohibit exercise Amputees Registered blind - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Differences in Speed of Recovery From Anesthesia for Intraoral Surgery
Status: Not yet recruiting

The goal of this clinical trial is to compare two groups of patients going in general anesthesia for intraoral surgery, the first group TIVA with propofol and the second group inhalational with sevoflurane. The main questions it aims to answer are to asses speed and quality of recovery from general anesthesia.

Participants will fill out a questionnaire to evaluate the quality of recovery from anesthesia using the QoR-40 1h, 24h, and 30 days after waking up from anesthesia in comparison to the results of the same questionnaire before surgery. Also, the investigators will perform a hand grip and bite strength test on the patients after waking up from anesthesia in the operating room, after 1 hour in the recovery room, and after 24 hours compared to preoperative values.

The investigators will compare TIVA and Volatile groups to see if there are any differences in recovery seed, muscle strength recovery, postoperative nausea and vomiting, and shivering between groups.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  patients older than 18 years ASA status 1-3, Patients who have an indication for an intraoral surgical procedure longer than 30 minutes. patients who agreed to the research and signed the consent  Exclusion Criteria:  ASA status higher than 3, the need for postoperative care in the ICU, surgery lasting more than 2 hours, known allergies to drugs used in the trial, refusal to participate - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Dry Needling and Therapeutic Exercise on Sleep in Individuals With Chronic Neck Pain and Sleep Disturbance
Status: Not yet recruiting

Feasibility study investigating the effects of dry needling on individuals with chronic neck pain and sleep disturbance.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Neck pain lasting greater than 3 months 28,29 Age: 18-75 years Presence of sleep disturbance - to be defined as a score ≥ 8 on the Insomnia Severity Index Ability to understand study procedures and to comply with them for the entire length of the study  Exclusion Criteria:  Previous surgery to the neck or thoracic spine Central nervous system disorders Systemic joint disease (e.g. rheumatoid arthritis) Infection Cancer Raynaud's disease Pregnancy Immunocompromised disease (e.g., diabetes mellitus, HIV, AIDS, lupus) Insufficient English-language skills to complete all questionnaires.  Contraindications to dry needling:  Presence of needle phobia History of abnormal reaction to needling or injection History of bleeding disorder (e.g., current anticoagulant therapy or known thrombocytopenia) - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult
Chinese Obesity and MEtabolic Surgery Database (COMES Database)
Status: Recruiting

The purpose of the Chinese Obesity and MEtabolic Surgery Database (COMES Database) is to collect data and examine the long-term effects of metabolic and bariatric surgery on obesity and metabolic disorders in the Chinese population.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients diagnosed as obesity undergoing metabolic and bariatric surgery.  Exclusion Criteria:  Patients treated by non-surgical modalities. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - StdAgeList: Child, Adult, Older Adult - StudyPopulation: Patients diagnosed as obesity undergoing metabolic and bariatric surgery. - SamplingMethod: Non-Probability Sample
Evaluation of Memantine in the Preservation of Memory and Neurocognition Following CSI
Status: Recruiting

The goal of this clinical trial is to evaluate the role of memantine in preservation of memory and neurocognition in patients undergoing craniospinal irradiation. Participants will be randomised into two arms and the interventional arm will receive memantine along with the standard treatment. Researchers will compare the neurocognitive tests of participants in both the arms to see if memantine leads to significant preservation of memory and cognition post radiation therapy.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age at irradiation: 5 to 39 years Planned for CSI (with or without boost dose) with or without systemic chemotherapy Informed consent or assent taken Karnofsky Performance Status / Lansky Performance Status ≥ 60  Exclusion Criteria:  Re-irradiation Prior exposure to memantine Inability to undergo Wechsler test - HealthyVolunteers: No - Gender: All - MinimumAge: 5 Years - MaximumAge: 39 Years - StdAgeList: Child, Adult
A Prospective Study on the Treatment of cLM Based on ICG Imaging
Status: Recruiting

The goal of this prospective randomized controlled study is to explore the role of indocyanine green-fluorescence imaging in management of cystic lymphatic malformation.. To clarify the application value of indocyanine green-fluorescence imaging in both diagnosis and treatment of cystic lymphatic malformation (cLM) in children, is helpful for exploring pathogenesis of cLM, and providing a clearer scientific basis for subsequent surgical intervention. It also provides alternative for the future diagnosis and treatment of cLM.

Participants will receive indocyanine green-fluorescence imaging before operation, while the patients in control group will receive traditional operation.

Researchers will compare difference in curative effect between two groups.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  (1) no previous intervention; (2) cLM diagnosed by pretreatment magnetic resonance imaging (MRI); (3)3 to 6 months post-treatment follow-up; (4) Superfacial cLM  Exclusion Criteria:  (1) history of iodine allergy; (2) syndromic cLM ; (3) severe liver and kidney dysfunction; (4) intralesional hemorrhage; (5) intralesional infection - HealthyVolunteers: No - Gender: All - MinimumAge: 30 Days - MaximumAge: 16 Years - StdAgeList: Child
Chinese Occupational Population Cohort of Lifestyle and Physical Fitness (LiFitChina)
Status: Recruiting

The incidence and prevalence of metabolic risk factors such as obesity, hypertension, diabetes, and dyslipidemia, as well as cardiovascular diseases (CVD), are continuously rising among the occupational population in China, primarily comprising the middle-aged and young adults. Unhealthy lifestyles and declining physical fitness are independent risk factors affecting cardiovascular health. Additionally, the level of physical fitness is influenced by postnatal lifestyles. Lifestyle factors related to cardiovascular health in the occupational population encompass various aspects, including smoking, physical activity, diet, sleep, psychological stress, etc. These factors may interact or have a synergistic effect, necessitating a comprehensive assessment.

This project proposes a prospective cohort study design to establish a monitoring cohort for lifestyle and physical fitness among the occupational population. The study will track and follow individuals with or without any CVD metabolic risk factors, collecting information on general status, lifestyle, physical fitness, and health examination data. Exposure factors such as lifestyle and physical fitness will be measured annually, and the occurrence of CVD-related health outcomes will be observed. The aim is to develop a comprehensive evaluation index for cardiovascular health lifestyle, analyze the direct and indirect impacts of lifestyle and physical fitness on the occurrence and development of CVD, and explore potential mediating and moderating effects of physical fitness in the association between lifestyle and cardiovascular health.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  adults between 18-59 years of age occupational staff willing to accept long-term follow-up  Exclusion Criteria:  participants with previous CVD history such as myocardial infarction, stroke and severe aortic stenosis; with cancer; with congenital genetic diseases, or cannot cooperate with the investigation and follow-up due to acquired diseases, such as congenital heart disease, paralysis, deafness, dementia, mental abnormality, developmental retardation, etc.; with exercise contraindications; duration of pregnancy; refuse to sign the informed consent. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 59 Years - StdAgeList: Adult - StudyPopulation: occupational person free of cardiovascular disease at baseline in China - SamplingMethod: Non-Probability Sample
PaThERAS: ERAS Protocols in Thyroid & Parathyroid Surgery
Status: Recruiting

Enhanced recovery after surgery protocols are evidence-based multidisciplinary programs implemented in the perioperative setting to improve postoperative recovery and attenuate the surgical stress response. They have been used with success after many different types of surgery to improve perioperative patient outcomes. However, evidence on their effectiveness in thyroid and parathyroid surgery remains sparse. Goal of PaThERAS study is to investigate the clinical benefits and cost-effectiveness of enhanced recovery protocols for the perioperative management in patients undergoing total thyroidectomy for large goiters/ cancers and parathyroidectomy for symptomatic hyperparathyroidism in non-day-care setting.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients diagnosed to have ASA Grade 1 and Grade 2 patients with thyroid and/or parathyroid (1° and 2° hyperparathyroidism) disease undergoing the following procedures via open or endoscopic approach • Total thyroidectomy/Focused parathyroidectomy/BNE with excision of enlarged glands +/- any additional procedure (Eg: Central compartment neck dissection, Lateral neck dissection, Cervical thymectomy etc)  Exclusion Criteria:  Patients undergoing thyroid and/or parathyroid surgery who  Undergo hemithyroidectomy Refuse to consent to participate in the study in the cohort group ASA Grade 3 and Grade 4* *Comorbidities of severe nature which may independently impact perioperative hospital stay, complications and outcomes in the study and control group - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
The Effect of Airway and Chest Wall Oscillation on Respiratory Functions in COPD Patients in Acute Exacerbation
Status: Not yet recruiting

Chronic obstructive pulmonary disease (COPD); It is a common, treatable and preventable disease characterized by progressive and irreversible airflow limitation and has systemic effects with respiratory system involvement. Increased respiratory workload, decreased work .

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Being classified as GOLD stage 3 or 4 based on spirometric evaluation in the medical history. Having a hospital admission within the specified time frame, evaluated by a pulmonary specialist, and admitted to the pulmonary diseases service with a diagnosis of COPD exacerbation. Being 40 years of age or older. Voluntarily agreeing to participate in the study.  Exclusion Criteria:  Having a hospital admission with a diagnosis of asthma attack in the last 5 years. Monitoring suspicious focal points for pneumonia on lung radiology. Hospitalization due to reasons other than exacerbation despite having a diagnosis of COPD. Presence of pulmonary fibrosis or suspicious findings of fibrosis on radiology. Systemic fungal infections. Having cognitive impairment affecting the decision to participate in the study, such as confusion, orientation disorder, or dementia. Patients with lung cancer or metastasis in the lungs. Diagnosis of conditions provoking shortness of breath other than COPD exacerbation, such as pneumonia, pneumothorax, heart failure, and pulmonary embolism. Presence of a new-onset rhythm disorder or ischemic changes requiring intervention on the EKG, excluding sinus tachycardia and multifocal atrial tachycardia. Chronic kidney failure requiring hemodialysis. Patients with conditions causing weakness in the lower extremities, such as arthritis, neurological disease, deep vein thrombosis, peripheral artery disease, muscle weakness, fractures, osteoarthritis, etc. Having ankylosing spondylitis with a Cobb angle of 10 degrees or more in the radiographic evaluation of the vertebral column. Having undergone surgery on the upper extremities, lower extremities, neck, and back. - HealthyVolunteers: No - Gender: All - MinimumAge: 40 Years - StdAgeList: Adult, Older Adult
Nasogastric/Orogastric Tube Placement Confirmation in Neonates Utilizing Self-contained pH Device, a Feasibility Study
Status: Recruiting

This study is looking at using a self-contained pH device that will assist in confirming placement of a nasogastric or orogastric tube placed in the stomach of hospitalized infants.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  All patients admitted to the NICU at the University of Minnesota Masonic Children's Hospital, Minneapolis, MN requiring placement of an NG/OG tube are eligible to enroll.  Exclusion Criteria:  Participant deemed unsuitable for study by the treating provider. Participants who are on the following medications: proton-pump inhibitor (PPI's) or H2 blockers within one week prior to the device assessment. - HealthyVolunteers: No - Gender: All - MaximumAge: 2 Years - StdAgeList: Child - StudyPopulation: Infants admitted to the University of Minnesota Masonic Children's Hospital neonatal intensive care unit. - SamplingMethod: Non-Probability Sample