rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
A Study on Self-Compassion,Depression,and Quality of Life Among Primary Caregivers of People With Dementia
Status: Recruiting

The goal of this observational study is to investigate the correlation between self-compassion, depression, and quality of life among primary caregivers of persons with dementia.

The main questions it aims to answer are:

What is the current status of self-compassion, depression, and quality of life among primary caregivers of persons with dementia?
Are there differences in self-compassion, depression, and quality of life among primary caregivers of persons with dementia based on different background variables?
What is the correlation between self-compassion, depression, and quality of life among primary caregivers of persons with dementia?

Participants will fill out the questionnaire to complete the study.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  primary caregivers of dementia patients diagnosed by specialists aged 18 and above who spend 8 hours or more daily (including overnight caregivers) providing care  Exclusion Criteria:  Those who do not agree to participate in the research Caregivers in a paid relationship with dementia patients, such as foreign domestic helpers and government-provided resident care attendant - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 99 Years - StdAgeList: Adult, Older Adult - StudyPopulation: The study will include primary caregivers of people with dementia. Participants will be adults aged 18 years and older who are currently providing care for a family member , Participants will be recruited from NTUH Neurology ward and Out-Patient Departments (OPD). - SamplingMethod: Probability Sample
Molecular Signature of Inactivity Induced Exercise Responsiveness
Status: Recruiting

Fitness is one of the best predictors for heart and brain disease. To increase ones fitness, the American Heart Association (AHA) says to exercise at least 150 minutes per week or 75 minutes per week if really hard. These exercise guides are pretty effective, however not everyone will get the same results. What individuals do outside of the exercise bout can influence the effectiveness of exercise. One of these factors is our time sitting, which has caused the phrase "sitting is the new smoking". Other studies have said that the metabolic benefits of exercise are decreased when you exercise after a few days of low activity (less than 5,000 steps per day). This is important in that exercise may not be able to fully offset these times of inactivity. However, these studies were only looking at different fats in the blood. As exercise increases fat burn up to 10 times in the muscle, more research is needed to understand how inactivity affects the muscle during exercise and after exercise. This study will help answer two questions: 1) How does a day of sitting a lot affect the muscle's ability to respond to exercise? and 2) How does a day of sitting a lot affect carbohydrate and fat burn during and after a bout of exercise? The investigators will answer these questions by having people complete one day of inactivity (less than 5,000 steps) or normal activity (more than 8,500 steps). Subjects will then come in the next day to bike somewhat hard for 1 hour. The investigators will take blood samples before, during, and after exercise to measure energy sources. The investigators will also collect pieces of skeletal muscle before and after exercise to see how the muscle responded to exercise. This study is significant for the publication of exercise guidelines to minimize risk of heart and metabolic diseases.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  free from acute or chronic illness (cardiac, pulmonary, liver, or kidney abnormalities, cancer, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other known metabolic disorders) free from orthopedic limitations (including any artificial joints) no known lidocaine allergy do not currently smoke or participate in other forms of tobacco use. not currently in a structured exercise program - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 35 Years - StdAgeList: Adult
The Effect of Semaglutide on Cardiovascular Markers and Liver Function
Status: Recruiting

Fifty patients with diabetes mellitus type 2 and non-alcoholic fatty liver disease (NAFLD) will be enrolled in the study.

25 patients will treated with semaglutide and 25 patients with dipeptidyl peptidase 4 (D-PP4) inhibitors.

At baseline, at four and at 12 months will evaluate the endothelial, cardiovascular and liver function.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Diabetes Mellitus type 2 NAFLD  Exclusion Criteria:  malignancies chronic inflammatory disease chronic kidney disease (estimated glomerular filtration rate <60 ml/min/m2 for a period of at least 90 days) peripheral vascular disease retinopathy previous therapy with a Glucagon-like peptide-1 agonist. None of the female patients was on hormone replacement treatment. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult - StudyPopulation: 50 subjects with T2DM and NAFLD, who attended the Diabetes Outpatients Clinic were enrolled in the study. 25 patients will reciece semaglutide 1 mg (treatment group) and 25 patients will receive DPP-4 inhibitors (either linagliptin or alogliptin or vildagliptin or sitagliptin - control group). Exclusion criteria were malignancies, chronic inflammatory disease, chronic kidney disease (estimated glomerular filtration rate <60 ml/min/m2 for a period of at least 90 days) peripheral vascular disease, retinopathy, and previous therapy with a Glucagon-like peptide-1 agonist. None of the female patients was on hormone replacement treatment. - SamplingMethod: Probability Sample
Effect of Vitamin D Injection on Hypertrophic Scars and Keloids
Status: Not yet recruiting

Scars and keloids cause patients severe morbidity and psychological distress. Hypertrophic scars rise above the skin but stay within the scar boundaries, while keloids expand.

The development of keloids and hypertrophic scars is a consequence of insufficient wound healing. These lesions are distinguished by excessive ECM deposition. Excessive ECM deposition is caused by increased inflammatory and proliferative processes and decreased remodeling activities. These scarring lesions are also linked to genetic and systemic causes

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  - Age from 12 years to 50 years. Patients with hypertrophic scars and keloids  Exclusion Criteria:  Age below 12 years and above 50 years. Patients received other treatment modalities for hypertrophic scars and keloids.  Systemic and other skin diseases. Patients were already receiving supplemental vitamin D. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 50 Years - StdAgeList: Adult
Virtual Reality on Pulmonary Function After Upper Abdominal Surgeries
Status: Recruiting

After upper abdomen surgery, respiratory muscle dysfunction is well recognised. After laparotomy and even laparoscopy, maximum static inspiratory and expiratory pressures are lowered, and recovery can take several days. A variety of reasons have been implicated in such respiratory muscle dysfunction, including irritation and inflammation, as well as injuries near the diaphragm, resulting in local mechanical failure, reflex inhibition, and pain.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients undergone open upper abdominal surgery (hernia repair, cholecystectomy, large bowel removal, conventional laparotomy) no prior surgical intervention for esophageal, gastric, or biliary tract resection age 18-60 years acceptable physical condition (permitting pulmonary function and functional capacity test).  Exclusion Criteria:  Cerebrovascular disease use of immunosuppressants within 30 days of surgery cardiovascular instability chest physical therapy within the 8 weeks preceding study enrollment visual impairment or hearing impairment; bed-ridden patients; any lung disorders insulin-dependent diabetes mellitus less than 6-months post thoracic or cardiac surgery musculoskeletal impairment cognitive disorders Patients undergoing laparoscopic surgery as this induces smaller changes in the postoperative breathing mechanics than laparotomy does heavy smokers or alcoholism - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 60 Years - StdAgeList: Adult
Single-center, Prospective Study on the Identification and Delineation of Brain and Lung Tumors and At-Risk Organs, and Functional Testing of Surrounding Tissues Based on Dual-Energy CT
Status: Recruiting

This study explored the feasibility of dual-energy CT in head and lung tumors. Dual-energy CT can achieve quantitative CT imaging based on traditional imaging by dual-energy spectral imaging, and enhance the clarity of head and lung tumors. In this study, we will prospectively explore the image accuracy and delineation accuracy of dual energy CT in radiotherapy to verify whether dual energy CT performs better with conventional CT.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Voluntarily participate in and sign the informed consent in person. 2. Over 18 years old, gender unlimited; 3. After imaging diagnosis of primary lung cancer or space-occupying lung lesions with oligometastases, MDT decided to treat SBRT 4. Clinical stage IA-IV (cT1-4N1-3M0-1); 5. No serious abnormality of blood system, heart, lung, liver, kidney function and immune deficiency; 6. Coagulation function: activated partial thromboplastin time (APTT) < the upper limit of normal 10 seconds, prothrombin time (PT) < the upper limit of normal 3 seconds, plasma fibrinogen 2-4g/L; 7. Hemoglobin ≥100g/L, WBC≥4×109/L, neutrophils ≥1.5×109/L, platelets ≥100×109/L 8. Bilirubin < 1.5 times the upper limit of normal value; Glutamic oxalic aminotransferase (ALT) & Glutamic pyruvic aminotransferase (AST) ≤1.5 times the upper limit of normal value; 9. Serum creatinine ≤1.5 times the upper limit of normal value; 10. The willingness of men or women of childbearing age to use contraception in the trial; 11. Physical condition score ECOG level 0 ~ 2; 12. Expected survival >3 months;13, Can acquire MRI scanning  Exclusion Criteria:  Patients could not tolerate or were unwilling to undergo CT examination; 2. The primary lesion has undergone surgery or radiotherapy or chemotherapy or targeted or immunotherapy; 3. Subjects who have received other drug trials within the last 1 month; 4. People with severe allergic history or idiosyncrasies; 5. Patients with a history of severe lung or heart disease; 6. Severe comorbidities, such as uncontrolled hypertension, heart failure, etc.; 7. Pregnant or lactating women; 8. Previous history of malignant tumor; 9. Refusal or inability to sign informed consent to participate in the trial; 10. Currently or planning to participate in other clinical trials; 11,Can not acquire MRI scanning - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: All patients with primary or metastatic tumors in the lungs and brains, in good general condition and are proposed to undergo SBRT - SamplingMethod: Non-Probability Sample
Focal Microvibration and Chronic Lumbosacral Radicular Pain
Status: Not yet recruiting

The goal of this clinical trial is to investigate the effectiveness of focal microvibration on patients affected by chronic lumbosacral radicular pain. The main question[s] it aims to answer are:

Can focal microvibration improve pain in this patient population?
Can focal microvibration improve quality of life in these patients? Participants will attach to their skin four little devices (10x20x0,5mm) delivering focal microvibration in the painful area according to researchers indications for 6 hours/day every day except Thursday and Sunday.

Researchers will compare patients treated with focal microvibration to patients treated with a sham device and to patients treated with standard pharmacological therapy.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Pain duration≥6 months Magnetic resonance imaging (MRI) showing compression of lumbosacral nerve roots Neuropathic symptoms in the innervation territory of the compressed spinal nerve roots Monolateral pain Pain intensity: moderate-severe i.e. numeric rating scale (NRS)≥4.  Exclusion Criteria:  Psychiatric patients Cancer patients Patients affected by disease characterized by spasticity or muscular stiffness:  Parkinson's disease, multiple sclerosis, stroke, spine injuries.  Patients with spinal or dorsal root ganglion stimulators Patients undergone central of peripheral stimulation in the past 3 months Patients affected by fibromyalgia. Patients undergone central nervous system surgery Patients with reduced renal function eGFR≤60ml/min/1,73m2 - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Effectiveness and Safety of Finerenone in Chinese CKD Patients Without Diabetes Mellitus
Status: Recruiting

Background： This study aimed to evaluate the effectiveness and safety of Finerenone in patients with chronic kidney disease (CKD) without diabetes mellitus(DM), however, evidence based on both clinical trails and real-world data are limited.

Methods:

Patients with CKD without DM were enrolled in this study from December 2022 to December 2024. In conjunction with the established treatment regimen for chronic kidney disease (CKD), study participants were additionally administered Finerenone. To evaluate the therapeutic impact and safety profile of the intervention, three primary biomarkers were monitored: 24-hour urinary protein (UTP), estimated glomerular filtration rate (eGFR), and serum potassium (sK+). These parameters were closely measured on a monthly basis, starting from the point of enrollment and continuing for a duration of twelve months or possibly longer.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  CKD without diabetes  Exclusion Criteria:  CKD with diabetes - HealthyVolunteers: No - Gender: All - MinimumAge: 20 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult - StudyPopulation: the medical histories of 43 individuals who received outpatient services at the Department of Nephrology in The First Affiliated Hospital of Harbin Medical University, located in Harbin, China. - SamplingMethod: Non-Probability Sample
The AI-CAC Model for Subclinical Atherosclerosis Detection on Chest X-ray
Status: Not yet recruiting

The AI-CAC model is an artificial intelligence system capable of assessing the presence of subclinical atherosclerosis on a simple chest radiograph. The present study will provide prospective validation of its diagnostic performance in a primary prevention population with a clinical indication for coronary artery calcium (CAC) testing.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Consent to participate in the study Age between 40 and 75 years Clinical indication from the treating physician to undergo chest CT for CAC score evaluation  Exclusion Criteria:  Prior cardiovascular events (myocardial infarction, coronary revascularization, transient ischemic attack, stroke, symptomatic peripheral vascular disease, arterial revascularization of peripheral districts) Cancer or other chronic diseases with an estimated prognosis of less than five years Technical contraindications to the execution of chest CT with electrocardiographic gating (highly penetrant atrial fibrillation, frequent ventricular extrasystoles) - HealthyVolunteers: No - Gender: All - MinimumAge: 40 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult
The Effect of Esketamine on Postoperative Pain Relief in Patients Undergoing Laparoscopic Surgery
Status: Recruiting

The purpose of this study is to investigate whether continuous intraoperative infusion of esketamine combined with the addition of esketamine to postoperative PCIA can improve postoperative pain and sleep quality in patients undergoing laparoscopic uterine surgery under general anesthesia.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patient Undergoing laparoscopic uterine surgery under general anesthesia (total hysterectomy, myomectomy); Patients gave the informed consent and signed the informed consent form. The ASA is Ⅰ-Ⅱ  Exclusion Criteria:  Patients allergic to anesthetics, ropivacaine, and esketamine or with contraindications to use; Patients with cognitive dysfunction or an inability to communicate; Transfer to the ICU after surgery; Patients with hyperthyroidism, tachyarrhythmia, or severe hypertension; Unwilling to use PCIA or refuse to participate in this trial; Patients with liver and kidney dysfunction - HealthyVolunteers: No - Gender: Female - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult
KAP for Use of SDF Among Dental Interns Before vs After Educational Intervention
Status: Not yet recruiting

This study is a KAP questionnaire to assess Egyptian intern dentists' knowledge, attitudes and practices regarding use of SDF before and after an educational intervention.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  - Dental Interns who are enrolled in the pediatric dental department, Faculty of Dentistry, Cairo University who are willing to participate.  Exclusion Criteria:  Dental Interns who are enrolled in the pediatric dental department , Faculty of Dentistry, Cairo University who are unwilling to participate. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - StdAgeList: Child, Adult, Older Adult - StudyPopulation: Interns who graduated dental school and are currently enrolled in the pediatric dental department, Faculty of Dentistry, Cairo University - SamplingMethod: Probability Sample
A Clinical Trial to Evaluate the Time Point of Anti-VEGF Pretreatment of PDR Based on Intraoperative FFA
Status: Not yet recruiting

The goal of this prospective randomized controlled study is to compare the therapeutic effect of injecting anti-VEGF drugs before surgery for patients with proliferative diabetic retinopathy at different time points. At present, studies have confirmed that anti-VEGF drugs are effective in inhibiting fundus neovascularization in proliferative diabetic retinopathy. The main question it aims to answer is which time point is better to injecting anti-VEGF drugs before surgery for patients with proliferative diabetic retinopathy.

Participants will be randomly divided into three groups. And time points of injecting anti-VEGF drugs before surgery for each group will be 3 days, 7 days, 14 days. And we have a new technology that can have fluorescein fundus angiography during operation, so it can reflect the condition of fundus neovascularization immediately and precisely. In that case, we can compare the Inhibitory effect of anti-VEGF drugs on fundus neovascularization at different time points.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  PDR is diagnosed in people 18 years of age or older with type 1 or type 2 diabetes， Hemoglobin A1c (HbA1c) ≤10% Persistent vitreous hemorrhage for more than one month or recurrent vitreous hemorrhage (within six months) Did not undergo retintis photocoagulation (PRP) Vitreous hemorrhage disease course within six months  Exclusion Criteria:  Patients who have had previous vitreoretinal surgery Intravitreal drug injection within 3 months Eye diseases other than PDR that may hinder vision improvement, such as optic atrophy or macular hole Thromboembolic events (including cerebrovascular or myocardial infarction) or clotting system disorders or receiving anticoagulation or antiplatelet therapy B-ultrasound or indirect fundus microscopy showing retina detachment (pull or hole origin) Vitrectomy, FFA contraindicated patients, patients with severe abnormality of cardiopulmonary, liver and kidney function - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Surgical Site Infections and the Microbiome: Understanding the Pathogenesis of Surgical Site Infections
Status: Not yet recruiting

This is a prospective, observational study of patients undergoing open GI surgery. At the time of operation, samples will be collected from the incision site and GI tract. The study will follow patients up to 30 days postoperatively, monitoring for signs of SSI. Samples will be taken from all patients who develop SSI. Sequencing will be performed on a subset of samples based on our specific aims.

Aim 1: conduct a case-control study of patients with SSI and age-, sex-, diagnosis-, and wound class-matched control patients without SSI, comparing microbiome alpha diversity and community composition with 16S RNA sequencing to determine the association with SSI.
Aim 2: identify the strain of bacteria isolated from SSIs using shotgun metagenomic sequencing and determine whether the specific strain was present in the skin and gut at the time of operation.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  We will include adult patients (age ≥ 18 years) Undergoing open abdominal surgery during the study period. Open abdominal surgery will include any abdominal procedure entering the peritoneal cavity through a midline incision with a skin incision that is 5cm or greater.  Exclusion Criteria:  Patients with planned minimally invasive surgery including laparoscopic or robotic surgery as these patients have lower rates of surgical site infections (SSIs). Patients who have a laparoscopic or robotic surgery converted to open surgery will be excluded. Appendectomy and cholecystectomy as these patients have lower risk of SSI. Vascular, gynecological, obstetric, urological or transplantation. Trauma patients. Patients without source control at the index operation including those with an open abdomen, no fascial closure, or temporary abdominal closure device (such as abthera dressing). Pediatric patients (age<18 years). Patients who decline swab/specimen collection. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: adults over the age of 18 years, who are undergoing open abdominal surgery with a midline incision. - SamplingMethod: Non-Probability Sample