rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
Effects of Autostereoscopic 3D Visual Training on Binocular Vision Function of Myopes
Status: Not yet recruiting

This study intends to conduct a relatively comprehensive binocular visual function examination and follow-up on two groups of myopic subjects, one receiving autostereoscopic 3D vision training and the other receiving 2D vision training as a control. The aim is to explore the impact of autostereoscopic 3D vision training on the accommodation and convergence functions of myopes. Additionally, synchronized EEG-fNIRS signals will be collected to investigate whether changes in binocular visual function are accompanied by corresponding alterations in brain function.

Eligibility:
- EligibilityCriteria: Inclusion criteria:  Age 18 to 30 years  Refractive errors:  spherical: -9.00 to -0.50 diopters (D), cylindrical: -2.50 to -0 D, and binocular difference within 2.0 D  Monocular best-corrected visual acuity ≥20/20 Normal stereoacuity Participants capable of understanding the purpose of this study and providing informed consent Participants capable of cooperating with relevant examinations.  Exclusion Criteria:  History of ophthalmic disease other than refractive error, such as strabismus, cataracts, glaucoma, retinal or optic nerve diseases Use of any medications affecting accommodative function or wearing orthokeratology lenses in the past 1 month History of ocular trauma or surgery Suffering from systemic or mental illnesses. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 30 Years - StdAgeList: Adult
A Study on the Correlation Between Endometriosis and Intra-tissue Microbiota
Status: Recruiting

Endometriosis (EM) is a common gynecological condition, but the pathogenesis of it has not yet been clarified. Here, the investigators wanted to investigate the correlation between endometriosis and the intra-tissue microbiota. The investigators planed to collect serum, vaginal swabs, cervical mucus, feces, peritoneal fluid, and endometrial tissue for sequencing and experiments.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Women aged 18-52 years old. Regular menstruation with a cycle of 28-35 days. No sexual intercourse 1 week before the operation. No systemic or local use of antibiotics and probiotics for 6 months prior to surgery. No history of acute or chronic pelvic inflammatory disease. Subjects fully understand the significance of the study and sign the informed consent form.  Exclusion Criteria:  In pregnancy. Intraoperative conditions or pathological examination suggest a malignant or junctional disease. Severe anatomical abnormalities of the pelvis. Pelvic contamination with large amounts of blood during laparoscopic operation. History of gene therapy, blood transfusion, stem cell therapy, or bone marrow transplantation Psychiatric, personality disorders, or abuse of psychoactive substances. Immunodeficiencies, allergies, or autoimmune diseases. Contraindications to endotracheal intubation anesthesia. Absolute or relative contraindications to laparoscopic or hysteroscopic surgery. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - MinimumAge: 18 Years - MaximumAge: 52 Years - StdAgeList: Adult - StudyPopulation: Participants in this study will be recruited in the obstetrics and Obstetrics and Gynecology Medical Center of Zhujiang Hospital. With reference to the inclusion and exclusion criteria, patients admitted for surgery were under screening. - SamplingMethod: Non-Probability Sample
SOX Combined With Tislelizumab and LDRT for Neoadjuvant Treatment of Locally Advanced Gastric Cancer
Status: Not yet recruiting

Neoadjuvant chemotherapy or chemoradiotherapy has become the standard neoadjuvant regimen for locally advanced G/GEJ cancer and has been recommended by a series of treatment guidelines. Although with clinical benefits of neoadjuvant chemotherapy or chemoradiotherapy, the pCR and long-term survival rates are still unsatisfactory and perioperative treatment mode for locally advanced G/GEJ cancer still needs further optimization. In this study, we will explore the efficacy and safety of chemotherapy combined with tislelizumab and LDRT in the neoadjuvant treatment for locally advanced G/GEJ cancer.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age 18-75 years. Histologically or cytologically confirmed diagnosis of locally advanced G/GEJ adenocarcinoma (cT3-T4a, N+, M0) as assessed by exploratory laparoscopic surgery, ultrasonography and/or CT/MRI. Resectable G/GEJ cancer, as judged by experienced surgeons. Eastern Cooperative Oncology Group performance score (ECOG PS) ≤1. Agree to provide blood, feces, and tissue specimens. The expected survival is longer than 3 months. There was no previous antitumor treatment (including chemotherapy, radiotherapy, targeted therapy, immunotherapy, interventional therapy, and other treatments with antitumor effects). Adequate organ and hematological function. Strict contraception. Patients must be able to understand and be willing to sign the written informed consent form. A signed informed consent form must be appropriately obtained prior to the conduct of any trial-specific procedure.  Exclusion Criteria:  Undergoing other drug clinical trials or having participated in any drug clinical trials one month before enrollment. Other tumors that have not been treated or exist at the same time, except carcinoma in situ of the cervix, treated basal cell carcinoma or superficial bladder tumor. If the tumor was cured and no evidence of disease was found for more than 3 years, the patient can be enrolled. All other tumors must be treated at least 3 years before enrollment. Allergic to oxaliplatin, S-1, tislelizumab and similar drugs, or suspected allergies. With serious gastrointestinal diseases that affect the absorption of oral chemotherapy drugs, such as chronic inflammatory bowel disease. History of gastric perforation within 6 months. Clinical manifestations include significant arrhythmia, myocardial ischemia, severe atrioventricular block, heart failure, and severe heart valve disease; Or those with severe lung function impairment; Or those with impaired blood system, liver and kidney function who cannot tolerate radiotherapy and chemotherapy; Or severe bone marrow failure; Or those with uncontrollable infections. With uncontrollable mental illness. Pregnant or lactating women. Unable to comply with the research program or procedures. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult
Multimodality Imaging Assessment of the Severity of Mitral Regurgitation
Status: Recruiting

To investigate to assess the severity of mitral regurgitation by multimodality imaging.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  age ≥ 18 years old all-caused moderate or severe MR assessed by Trans-Thoracic Echocardiography (TTE) : 1) EROA ≥0.3cm^2; 2) RVol ≥45ml The patient has signed an informed consent form.  Exclusion Criteria:  unstable angina, acute myocardial infarction and surgical history of coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) within 3 months before recruit acute heart failure or acute worsening of chronic heart failure requiring vasoactive drug therapy severe infections, septicaemia severe hepatic insufficiency ( Child-Pugh class C) severe renal insufficiency ( chronic kidney disease (CKD) stage 5: estimated glomerular filtration rate (eGFR) <15ml/min or dialysis) hypotensive state, shock ( systolic blood pressure <90mmHg or mean arterial pressure <70mmHg with tissue hypoperfusion and urine output <30ml/h) uncontrolled diseases of the haematological system: acute gastrointestinal bleeding, intracranial haemorrhage or haemorrhage from other organs, acute pulmonary embolism or deep vein thrombosis, congenital or acquired haemorrhagic disease such as haemophilia, anaphylactic purpura and acute leukaemia, severe abnormalities in haematological parameters such as platelet count <20*10^9/l and international normalized ratio (INR) >3 contraindication for Trans-Esophageal Echocardiography (TEE) such as oesophageal constriction, oesophageal tumour, oesophageal fistula, oesophageal varices, cervical vertebral instability contraindication for CMR such as metal foreign matter in the body, claustrophobia contraindication for intravenous anaesthesia such as allergy to anaesthetics pregnancy or breastfeeding The patient does not sign an informed consent form. Due to other reasons the patient is not suitable for enrollment assessed by the researcher. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Efficacy of Gamification With Escape-Room for Arrhythmia Identification in Critical Patients
Status: Recruiting

Introduction: Health education provided through the escape-room is still a recent approach in educational methodology and tends to be a strategy that benefits nursing students, particularly in gaining knowledge and skills. However, few studies have explored the use of both in-person and virtual escape-room as an educational methodology in nursing. Objective: To assess the effectiveness of the gamification strategy through the in-person escape-room model compared to the virtual model in enhancing cognitive and affective competencies for recognizing cardiac arrhythmias in critical care patients within the nursing field. Method: A randomized clinical trial to be conducted with nursing students from higher education institutions in the Federal District, Brazil. Students will undergo a theoretical class on cardiac arrhythmias in critical patients and will then be randomized to experience either the in-person or virtual escape-room scenario. Knowledge tests, the Depression, Anxiety, and Stress Scale, Satisfaction and Self-confidence Scale in nursing management learning, and perceived gains will be administered pre and post-intervention. Results with p≤0.05 will be considered significant. Expected Results: It is anticipated that this study will contribute to the enhancement and broadening of cognitive and affective competencies in nursing students, improving the quality of care through an active educational strategy like the escape-room, and consequently reducing costs for the Unified Health System by minimizing errors in recognizing clinical changes in critical patients. Additionally, the study aims to address gaps in understanding the use of educational escape-rooms in the field of nursing.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Students enrolled in the undergraduate nursing program who have successfully completed the course related to adult and elderly health.  Exclusion Criteria:  Healthcare professionals, including those participants who, at any point during the research stages, choose to withdraw or who have not completed/participated in one of the study phases. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
The Effect of Mint Flavored Chewing Gum on Hyperemesis Gravidarum Nausea Vomiting Severity, Coping With Stress and Anxiety Level in Pregnants With Hyperemesis Gravidarum
Status: Recruiting

In the research planned as a randomized controlled study, the experimental groups will be administered routine hyperemesis gravidarum (HG) treatment as well as chewing mint-flavored gum, while the control group will only receive routine HG treatment and no intervention will be performed. This study aims to contribute to the literature by investigating the effect of chewing mint-flavored gum on the severity of nausea and vomiting, coping with stress, and anxiety levels due to hyperemesis gravidarum in pregnant women.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Pregnant women aged 18 and over At least primary school graduate The one who is married Pregnant women who are younger than 16 weeks of gestation and diagnosed with hyperemesis Those who agreed to participate in the study  Exclusion Criteria:  Those with a history of chronic disease Having a health problem that may cause nausea and vomiting in the current pregnancy Those who are allergic to mint - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
The Effect of Breastfeeding Counseling on Social Support Perception, Breastfeeding Self-Efficacy and Outcomes
Status: Not yet recruiting

The purpose of this study is to examine the effects of the Breastfeeding Self-Efficacy Resources Development Nurse Consultancy Program (EMÖZGEDAP), based on Dennis's Breastfeeding Self-Efficacy Theory along with the hypno-breastfeeding philosophy given to mothers and family relatives, on social support perception, breastfeeding self-efficacy and outcomes. The study will involve pregnant women and close others assigned randomly to the intervention (n=50) or control (n=50) groups in a state hospital in Turkey. Individual counseling will be provided to the intervention group within the scope of the EMÖZGEDAP, based on Denis's Breastfeeding Self-Efficacy theory and hypnobreastfeeding philosophy. EMÖZGEDAP, which will be applied to pregnant women and their family relatives, will consist of 5 sessions lasting 7.5 hours (2 sessions with the woman and her family relatives, two sessions with the woman alone, and one with her family relatives alone). The Antenatal Breastfeeding Self-Efficacy Scale will be evaluated before the counseling program is given in the antepartum period. Breastfeeding and Nutrition Results, Postpartum Breastfeeding Self-Efficacy Scale, Breastfeeding Self-Efficacy Scale for Fathers, Assessment Scale for Perceived Support of Close Others in Relation to Breastfeeding Self-Efficacy and Scale of Perception of Close Others' Support For Breastfeeding Self-Efficacy will be evaluated at the 1st, 3rd, and 6th months postpartum.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Being 18 years or older, 28-37. be between weeks, Being primiparous, Having a healthy singleton pregnancy, Being at least a primary school graduate, Living with his/her spouse, There is a relative who will support the mother, whom she defines as a relative (spouse, the woman's mother, or mother-in-law), and this person also agrees to participate in the study, There is no condition that prevents breastfeeding for the mother and the baby (medication use, history of any psychiatric or chronic disease, history of any disease in the baby such as cleft palate-lip, etc.),  Exclusion Criteria:  Not filling out the forms in the study or filling them incompletely, The participant wishes to leave the research, The emergence of a condition that prevents breastfeeding in the mother and baby, Moving from the city where the work is done or moving out of the town, Family support is for less than 1 month, - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult
Comparison of Holmium Laser and Thulium Laser for Mini PCNL
Status: Not yet recruiting

This is a single institution, single surgeon, randomized controlled trial to evaluate the Boston Scientific Lumenis Pulse 120H Moses 2.0 holmium laser versus the Olympus Soltive Superpulsed thulium fiber laser (TFL) for medium-to-large stones in the mini PCNL setting.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Scheduled to undergo mini PCNL for nephrolithiasis Stone burden (multiple stones acceptable) with largest stone 1cm - 3 cm in greatest dimension on bone window of noncontrast CT within a 6 month preoperative period. Able to give informed consent Age 21 or older  Exclusion Criteria:  Patients scheduled to undergo concurrent non-PCNL procedure such as contralateral ureteroscopy Inability to give informed consent Age less than 21 Body Mass Index (BMI) >45 Pregnant or breastfeeding patients Stone burden outside of inclusion criteria range Untreated urinary tract infections Uncontrolled bleeding disorder and coagulopathy Abnormal upper tract anatomy such as presence of ureteral strictures or complete ureteropelvic junction (UPJ) obstruction Patients with urinary diversion such as ileal conduit or neobladder Any preexisting medical condition or situation that, in the investigator's opinion, could put the participant at significant risk, confound the study results, or interfere significantly with the participants' participation in the study Are currently prescribed buprenorphine or methadone, or carry active diagnosis of chronic opioid use disorder - HealthyVolunteers: No - Gender: All - MinimumAge: 21 Years - MaximumAge: 90 Years - StdAgeList: Adult, Older Adult
Impact Evaluation of a Targeted mHealth Intervention to Improve Uptake of Postpartum Contraception in Kenya
Status: Recruiting

The goal of this study is to explore approaches to improve postpartum contraceptive counseling, information, and uptake through a collaboration between the Harvard Chan School, Rutgers School of Public Health, Jacaranda Health, Jhpiego, and IPSOS, leveraging an existing mobile health platform for intervention delivery and Jacaranda's established partnership with the Kenyan Ministry of Health, county health offices and public maternity hospitals.

Jacaranda's PROMPTS mHealth platform has reached over two million pregnant women and new mothers, providing them with needed, tailored information about prenatal and postpartum health along with access to a mobile helpdesk to triage users' questions. Using a targeted human-centered-design process with early postpartum mothers, we developed targeted messaging around family planning and contraceptive method options, with the goal of integrating this new content into Jacaranda's PROMPTS platform. We will conduct a randomized controlled trial with pregnant women engaged with the PROMPTS platform to determine the impact of the intervention package on information and utilization of postpartum contraception. If proven effective, the results of this intervention will be integrated into Jacaranda's PROMPTS system at full scale.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age 15 and over, Pregnant at 7-8 months gestation, Consented to be enrolled in the PROMPTS text-messaging platform and who have provided informed consent to be part of this research study Have access to a mobile phone  Exclusion Criteria:  None - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - MinimumAge: 15 Years - StdAgeList: Child, Adult, Older Adult
Programmed Intermittent Epidural Bolus (PIEB) Techniques for Labour Analgesia
Status: Not yet recruiting

Epidural Analgesia remains the most effective form of pain relief in labour. After initiating epidural analgesia, there are many epidural drug regimens that can be employed to maintain analgesia for the duration of labour using an epidural catheter. Due to recent advances in medical technology, new epidural pumps, which allow both patient controlled epidural analgesia boluses (PCEA, a common standard of care in many hospitals) and programmed intermittent epidural boluses (PIEB, automatic boluses given in addition to the PCEA bolus), are now available. In this randomized double-blind trial, we aim to evaluate the effects of different combinations of PIEB (epidural bolus volume) and PIEB (bolus volume and time interval) on labour patient-controlled epidural analgesia (PCEA) usage. In theory, the more effective the PIEB combination (the ideal drug volume and ideal time interval), the less PCEA boluses (extra epidural drug) will be used as well as less clinician boluses and less lower limb weakness (motor block) as assessed by the Bromage Score.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age 18 to 50 yrs In active labour ASA 2 patients (pregnant patients are considered to be ASA 2) Singleton pregnancy > 37 weeks gestation Booking BMI 18 to 35  Exclusion Criteria:  BMI < 18 BMI > 35 Systemic opioids within the previous 6 hours Presence of a fetal anomaly Pre-eclampsia Bleeding disorders (including coagulation disorders) Recent spinal surgery Spinal injury Elevated intracranial pressure (ICP) Neuraxial disorders of any description Signs of local or systemic infection Patient refusal for neuraxial analgesia - HealthyVolunteers: No - Gender: Female - GenderBased: Yes - GenderDescription: parturient 37+ weeks - MinimumAge: 18 Years - MaximumAge: 50 Years - StdAgeList: Adult
T30 for Astigmatism in Digital Device Users
Status: Not yet recruiting

This study aims to determine if Total30 lenses for astigmatism can be successfully fit in participants who are heavy digital device users.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Adult (18- to 40-year-old) 0.00 LogMAR visual acuity or better in their habitual CLs or by manifest refraction in both eyes Smart phone with text messaging capabilities Existing wearers of soft, frequent replacement toric CLs within past 6 months Frequent digital device user (e.g., phone, iPad, computer, social media, video streaming, etc.) defined as at least 8 hours of usage per day Willing to follow the required wear schedule Astigmatism ranging from 0.75 D to 2.50 D in each eye Willing to wear their CLs at least 13 hours/day  Exclusion Criteria: Have known systemic health conditions that are thought to alter tear film physiology (e.g., Sjögren's syndrome).  Have a known history of being diagnosed with dry eye disease Have a history of ocular surgery within the past 12 months Have a history of severe ocular trauma, active ocular infection or inflammation Have a history of viral eye disease Currently using isotretinoin-derivatives or ocular medications Currently using a dry eye treatment including but not limited to artificial tears Currently using rewetting drops daily or occasionally If they are pregnant or breast feeding Need for spectacle add power of any amount (presbyopic) Currently wearing T30fA CLs Have a history of wearing hard CLs Subjects who show excessive lens oscillation with the T30fA lenses during the fitting process yet show 0.0 logMAR acuity, will be excluded from the study. Patients who report unstable vision while wearing their habitual or study CLs (e.g., rotational instability of CLs) Willing to not use any artificial tears or dry eye treatments during the study Willing to not use rewetting drops during the study - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 40 Years - StdAgeList: Adult