rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
Heavy Strength Training in Head and Neck Cancer Survivors
Status: Not yet recruiting

Despite improvements in treatments, head and neck cancer survivors (HNCS) still endure acute and chronic side effects such as loss of muscular strength, limitations in physical functioning, fatigue, and swallowing difficulties that impact quality of life (QoL) and limit return to work. Light-to-moderate intensity strength training (LMST) has been shown to improve some side effects. Heavy lifting strength training (HLST) may further improve outcomes in some populations, however, only one small pilot study has focused on HNCS. The LIFTING 2 trial will be the first to examine the feasibility and effects of a HLST program versus no exercise in HNCS.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  males and females, 18 years of age and older any head and neck cancer subtype, stage, and treatment type at least 1-year posttreatment with adequate shoulder range of motion (must meet minimum cutpoints for active flexion and abduction to be eligible) no unmanaged medical conditions, alcohol, or drug abuse approved for exercise by oncologist and a certified exercise physiologist or kinesiologist ability to understand and communicate in English  Exclusion Criteria:  has met the Canadian Physical Activity strength training guidelines within the past one-month: at least two days per week of muscle and bone strength training activities using major muscle groups currently involved in a different exercise trial or clinical drug trial - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Neural Mechanisms of Family-Focused Treatment for Youth Depression
Status: Not yet recruiting

The goal of this interventional study is to compare the baseline neural mechanisms and parenting in depressed and non-depressed children and to examine baseline neural mechanisms and parenting as predictors of Family-Focused Treatment for Childhood-Depression (FFT-CD) outcomes. The main questions it aims to answer are:

What are differences between depressed and non-depressed participants on baseline neural and parenting indicators?
Do baseline neural and parenting indicators predict response to FFT-CD?
Does change in parenting and neural functioning mediate change in depression from baseline to follow-up?

Participants will:

complete baseline clinical measures
complete neuroimaging tasks via Functional Magnetic Resonance Imaging (fMR)
undergo a 12-session course of FFT-CD
complete follow up evaluations and neuroimaging

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Children must:  Have a current DSM-5 diagnosis of MDD, Persistent DD, or DDNOS (based on K-SADS-PL) OR not meet criteria for any DSM-5 mental health diagnosis (based on K-SADS-PL) Be ages 7-12 Be living with a parent(s) or guardian willing to participate Be able and willing to provide informed consent/assent  Parent must:  Not be currently pregnant Be able to read, understand consent forms, and provide consent on their child's behalf Be the biological parent (or grandparent in parental role) of the participating child & have lived with the child for more than 75% of the child's life.  All participants must:  Not have a disturbance that would interfere with participation such as autism spectrum disorder, psychosis, current substance dependence, current use of psychotropic medication, OCD, or MRI contraindication such as metal inside the body or claustrophobia Be proficient in English  Exclusion Criteria:  Thought or other disturbance in the child that would interfere with the ability to participate in treatment or assessments (e.g., psychotic disorder, autism spectrum disorder, OCD, active substance abuse/dependence, intellectual disability, as assessed on KSADS-PL) Severe conduct disorders in the child that threaten the home stability (e.g. juvenile justice or children's protective service involvement as assessed on KSADS-PL) due to the potential impact on retention Youth or primary caregivers do not speak English Either parent or child has contraindications for neuroimaging (e.g., claustrophobia, metal implants, braces, electronically, magnetically, or mechanically activated devices such as cochlear implants) The child is on an antidepressant medication, as it may complicate neuroimaging interpretation. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 7 Years - MaximumAge: 12 Years - StdAgeList: Child
Effects of rTMS on Respiratory Function and Gut Microbiota in Patients With Brain Injury
Status: Not yet recruiting

Impaired respiratory function may occur after brain injury, and will progress to restricted respiratory dysfunction without early intervention. At present, there is a lack of effective treatment options for respiratory dysfunction. Repetitive Transcranial Magnetic Stimulation(rTMS) is a non-invasive, painless and non-invasive neuroregulatory technique. In healthy people, rTMS applied to the respiratory motor cortex induces a contralateral respiratory muscle response. However, whether rTMS can improve respiratory function in patients with brain injury remains unclear. gut microbiota can affect muscle function and mass, and animal experiments have shown that probiotics can increase skeletal muscle mass and grip strength in mice. On the other hand, studies have found that rTMS can improve the nutritional status of patients with vegetative state by regulating the structure of gut microbiota. However, it remains unclear whether rTMS can improve respiratory muscle function in patients with brain injury by regulating gut microbiota. Therefore, the investigators intend to apply rTMS to the respiratory motor cortex to observe whether rTMS can improve respiratory function and reduce the incidence of pneumonia in patients with brain injury, and to observe the role of gut microbiota in this process.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  In line with the diagnostic criteria of "Chinese classification of cerebrovascular diseases(2015)" mRS Score 2-4 points or craniocerebral injury caused by trauma, GCS score > 8 points Between 18 and 70 years old The first incidence of cerebrovascular disease or traumatic brain injury, and the course of disease was 10-180 days Vital signs are stable, no progression Voluntary participation with informed consent  Exclusion Criteria:  Patients with a history of respiratory disease, including chronic bronchitis, chronic obstructive pulmonary disease, bronchiectasis, and lung cancer Severe bone malformations in the chest or spine Have other neurological or neuromuscular disorders History of thoracic and abdominal surgery Severe heart, lung, kidney, liver or other organ dysfunction Pregnant and lactating women Epilepsy Metal implant Patients who were judged by the investigator to be unsuitable for participation in this trial - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 70 Years - StdAgeList: Adult, Older Adult
Personalized Innovative Intervention Pathways to Promote EF in Children With CP
Status: Not yet recruiting

Cerebral palsy (CP) is an umbrella term, covering a group of disorders of movement and posture. It is now accepted that CP represents much more than a disorder of movements considering the frequent association with a broad range of impairments, including cognitive impairments. In general, multiple clinical characteristics that define and determine different functional profiles. Several studies on children with unilateral and bilateral CP have been shown that, despite the overall preserved intellectual functioning, there are specific neuropsychological impairments distinguishing the two forms, including deficits in different Executive Functions (EF) components. Executive Functions (EFs) represent a complex cognitive domain consisting of a set of top-down functions essential for adaptive goal-directed behaviour, allowing to formulate, plan, and organise ideas, cope with challenges and novelties, resist temptations and stay focused. EF represents general domain abilities transversal to several cognitive processes and underling different daily life activities and school learning skills. Empowering EF becomes therefore crucial in children with CP both to strengthen specific functional EF weaknesses and to achieve far transfer effects on other compromised domains, such as motor planning, academic skills,and/or visuospatial processing. To pursue this, the EF training needs to be integrated into the complex and multidisciplinary care context promoting innovative intervention methodologies based on scientific evidence. Recent researches and clinical practice, carried out in our Institute, supports the effectiveness of innovative interventions on EF using new technologies in typical and atypical development, such as Self-adapting web based softwares, Game-based tools or Educational Robotics. Literature suggests these technologies allow to promote timely intervention within a user-friendly context, while respecting the key criteria of evidence-based neuropsychological rehabilitation, both reducing hospitalisation times and supporting interest and motivation for participation. The primary aim of this study is to evaluate the applicability of technological intervention integrated with psychomotor activities to promote EF and then secondary to measure the effect on the functional profile of children with CP, including motor planning, visuo-spatial processing and learning skills, evaluating both short-term (T2) and long-term changes (T3).

Eligibility:
- EligibilityCriteria: Children with Cerebral Palsy:  Inclusion Criteria:  Children with confirmed diagnosis of CP Ages from 5 to 13 years old At least one cognitive index > 85 at WPPSI-IV or WISC-IV Functional weakness in EF  Exclusion Criteria:  Severe comorbidities and/or severe cognitive disability  For Typically developing children:  Ages from 5 to 13 years old No documented clinically relevant disorders - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 5 Years - MaximumAge: 13 Years - StdAgeList: Child
Outcome Study of Conventional Steroids vs. Steroids Combined With Mycopehnolate in Newly Diagnosed Immune Thrombocytopenia Purpura.
Status: Recruiting

Immune thrombocytopenia Purpura (ITP) is an autoimmune condition delineated by humoral as well as cell mediated immune response against thrombocyte surface proteins GPIIb/IIIa receptors, affecting primary homeostasis leading to mucocutaneous bleeding.ITP is characterized by platelet count <100 x 109/L. The conventional line of treatment for newly diagnosed ITP is steroids but significant disadvantages have been associated with long term use and a high risk of relapse when reducing the dose. The addition of MMF to the first line treatment of ITP resulted in substantial response and a lower risk of refractory ITP with decreased financial burden and improved outcome.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age:5-60years Platelet count<30x109  Exclusion Criteria:  Pregnancy Lactation h/o hepatitis B and C HIV reactive patients allergic to drug - HealthyVolunteers: No - Gender: All - MinimumAge: 5 Years - MaximumAge: 60 Years - StdAgeList: Child, Adult
Erythritol vs Ultrasonic Scaler Prophylaxis Systems on Dental Implants With Crowns Made by Different Materials
Status: Not yet recruiting

The aim of the study is to assess which prophylaxis methods is the most suitable for peri-implant hygiene between erythritol and ultrasonic scaler with peek inserts.

A randomized clinical trial will be conducted on the patient. Patients will be randomly divided into two groups:

Erythritol group: erythritol with a particle size of ~14 µm will be used for 5 seconds (AIRFLOW® PLUS EMS)
Ultrasonic scaler group: a piezoelectric handpiece with peek inserts (Mini Piezon EMS; PI EMS) will be used.

Different subgroups will be defined according to the material of the dental crown of the related implant.

The oral hygiene session will be carried out every 6 months (2-years follow-up; 6 sessions), after instruction and motivation of the patient, completion of the clinical chart with the recording of the Probing Depth (evaluation in mm of the peri-implant sulcus taken by a periodontal probe; 4 surfaces of the gingival margin are detected: vestibular, palatal/lingual, mesial, distal), Bleeding on Probing and Plaque Index.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age between 18 and 70 Presence of at least one dental implant Good compliance  Exclusion Criteria:  Patients with cardiac stimulators Patients with neurological disorders Patients with psychological disorders Pregnant women - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 70 Years - StdAgeList: Adult, Older Adult
Impact of Earthquake Trauma on Nurses' Compassion Fatigue: A Study From Kahramanmaraş, Turkey
Status: Not yet recruiting

This study investigates the impact of earthquake trauma on compassion fatigue among nurses working in emergency services following the devastating earthquakes on 6 February 2023, in Kahramanmaraş, Turkey. These earthquakes, with magnitudes of approximately 7.7 and 7.6, affected 11 provinces and resulted in over 50,000 deaths and 100,000 injuries, placing emergency service nurses at the forefront of dealing with the aftermath and trauma. The concept of compassion fatigue, characterised by a reduced capacity for empathy after repeated exposure to traumatic events, is a significant concern for nurses who have been directly involved in the care of earthquake victims. This study aims to explore the extent of earthquake trauma and compassion fatigue among these nurses, examining the relationship between these two conditions and their long-term effects. Given the limited research on post-traumatic stress disorder and compassion fatigue among emergency service nurses, this study seeks to contribute valuable insights into the psychological impacts of disaster response on healthcare professionals. The hypotheses tested aim to better understand the risks and psychological burdens faced by nurses in the wake of such natural disasters.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Working in the emergency department of a hospital located in a province affected by the February 6 Kahramanmaraş earthquakes, Having worked in the emergency department for at least one year, Not having any psychiatric illness that could increase anxiety and stress levels in the last year, Not taking any medication that could affect anxiety and stress levels in the last year, Volunteering to participate in the study.  Exclusion Criteria:  Data from nurses who wish to withdraw from the study after inclusion will not be considered for the research. - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: The study targets emergency department nurses in areas affected by the February 6 Kahramanmaraş earthquakes in Turkey. These nurses, with at least one year of experience, have faced the disaster's challenges firsthand. The focus is on those actively involved in disaster response and recovery, excluding individuals with recent psychiatric conditions or medication that could influence stress levels. Participation is voluntary, ensuring data integrity and ethical standards. Nurses withdrawing from the study will have their data excluded. - SamplingMethod: Non-Probability Sample
A 12 Months Prospective Study Comparing Functional Outcome Scores in Hip Arthroscopic Labral Repair Versus Debridement
Status: Not yet recruiting

This study aims to address hip labral tears and compare between arthroscopic labral repair versus debridement.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Sex: both sexes. Age: 18 years - 60 years. Femoroacetabular impingement (FAI) including all types (cam, pincer, and combined). Traumatic Labral tears  Exclusion Criteria:  Previous hip surgery. Hip joint dysplasia, defined by both center edge (CE) angles <25 degrees and Acetabular Index angle >10 degrees. Osteoarthritis grade >2 according to Tönnis classification. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 60 Years - StdAgeList: Adult
Efficacy of Olanzapine on Weight Gain in Advanced Gynecologic Cancer With Paclitaxel and Carboplatin: a Double Blind, Placebo-controlled Randomized Trial
Status: Not yet recruiting

Efficacy of olanzapine on weight gain in advanced stage gynecologic cancer
Proprotion of pateints in advanced stage gynecologic cancer who recieving paclitaxel and carboplatin chemotherapy gain weight on olanzapine or placebo

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Advanced stage gynecologic cancer receiving Paclitaxel and carboplatin chemotherapy ECOG 0-1 Normal CBC,Liver, renal function Communication in Thai language or Thai caregiver Inform consent  Exclusion Criteria:  Pregnancy Active infection Bowel obstruction or history of bowel surgery On dopamine receptor antagonists or psychiatric or anticonvulsant medication Olanzapine allery Abnormal function of liver and renal Diabetic melitus or morbid obesity patient can't selfcare - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - MinimumAge: 18 Years - MaximumAge: 70 Years - StdAgeList: Adult, Older Adult
The Efficacy of Aerobic Exercise Training on Autonomic Nervous System and Endothelial Function in Patients With Compensated Cirrhosis
Status: Not yet recruiting

The goal of this clinical trial is to explore the impact of a 16-week aerobic exercise regimen on the autonomic nervous system and endothelial function in patients with compensated cirrhosis who maintain sedentary lifestyles. The primary research question is:

1) What effect does 16 weeks of aerobic exercise have on changes in the autonomic nervous system and endothelial function in cirrhotic patients?

Additionally, the secondary research questions are:

How does a 16-week aerobic exercise program influence changes in muscle mass, muscle strength, and physical performance in cirrhotic patients?
Is there a correlation between muscle mass and parameters of the autonomic nervous system in cirrhotic patients?

Participants in the intervention group will undergo 150 minutes of moderate aerobic exercise per week for 16 weeks, accompanied by a personalized nutritional plan (1.2 grams of protein per kilogram of ideal body weight per day and a calorie intake of 35 kilocalories per kilogram of ideal body weight per day). The control group will solely receive nutritional guidance and maintain their sedentary lifestyle. The researchers will compare outcomes between these two groups.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  The diagnosis of cirrhosis is confirmed either through liver biopsy or the presence of portal hypertension, evidenced by esophageal varices on endoscopy, ascites, and/or compatible features on ultrasonography. The age range is between 45 and 75 years. Participants are classified as Child Pugh score class A. Participants report a sedentary lifestyle, defined as engaging in physical activity for less than 150 minutes of moderate-intensity physical activity per week, or less than 75 minutes of vigorous-intensity physical activity per week, or an equivalent combination of both.  Exclusion Criteria:  Active hepatocellular carcinoma (HCC) or remission of HCC within the past 3 months. Untreated large esophageal varices (EV) greater than F2 or history of upper gastrointestinal bleeding from portal hypertension or gastric varices. Active or history of hepatic encephalopathy (HE). Inpatient hospitalization for any reason or discharge from the hospital within the past 3 months. Complete portal vein thrombosis. Transjugular intrahepatic portosystemic shunt. Contraindications to exercise, such as recent myocardial infarction, unstable angina, electrocardiography changes within the past 24 hours, complete heart block, acute congestive heart failure, uncontrolled hypertension, hemoglobin level less than 11 g/dL, platelet count less than 50,000 cells/mm 3 . Use of Vitamin E and C supplements. End-stage renal disease without dialysis. Severe orthopedic problems that limit the ability to exercise. Inability to communicate with the research team via telemedicine system. Body mass index (BMI) exceeding 30 kg/m 2 . - HealthyVolunteers: No - Gender: All - MinimumAge: 45 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult
Oral Fluid vs IV Fluid After Primary TKA
Status: Recruiting

The goal of this study is to compared efficacy of oral fluid and intravenous fluid after primary unilateral total knee arthroplasty.

The main question it aims to answer is:

Does oral fluid replacement after primary unilateral total knee arthroplasty provide a patient recover faster than intravenous fluids replacement?

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age 40-85 years old ASA I, II Primary osteoarthritis  Exclusion Criteria:  Diuretics use Morbid obesity Previous knee surgery Cannot undergo spinal anesthesia - HealthyVolunteers: No - Gender: All - MinimumAge: 40 Years - MaximumAge: 85 Years - StdAgeList: Adult, Older Adult
Study of Wilms Tumors Among Patients of Shefa Al-Orman Children Cancer Hospital
Status: Recruiting

The goal of this cross sectional observational study is to determine the percentage of Wilms tumors among pediatric cancers at Shefa Al-Orman Children Cancer Hospital from june 2020 to june 2024,to study the outcome of patients with Wilms tumor treated according to SIOP Umbrella protocol during the study period and to study the treatment related complications during therapy according to common terminology criteria of adverse events version 5.0 (CTCAE Version 5.0).

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Children and young adolescene younger than 18 years of age admitted and treated at Shefa Al-orman Children Cancer Hospital during the study period  Exclusion Criteria:  Patients aged older than 18 years old, died early at presentation before starting chemotherapy, patients with non-Wilms renal tumors, relapsed renal tumors. - HealthyVolunteers: No - Gender: All - MaximumAge: 18 Years - StdAgeList: Child, Adult - StudyPopulation: Children and young adolescene younger than 18 years of age admitted and treated at Shefa Al-orman Children Cancer Hospital during the study period - SamplingMethod: Probability Sample
Turkish Validity and Reliability of the Social Frailty Index
Status: Not yet recruiting

The aim was to examine the validity and reliability of the Social Frailty Index in Turkish among older adults. 65 years and above older adults will be included included in the study. Older adults who agree to participate in the study will first be administered the Hodkinson Mental Test. Those who score 6 points and above will be included in the study. To evaluate the validity of the &#34;Social Frailty Index&#34;, Social Inclusion Scale, Older people&#39;s quality of life-brief (OPQOL-brief) and Lubben Social Network Scale will be applied to the participants. To determine the reliability of the &#34;Social Frailty Index&#34;, older adults who do not receive any treatment will be tested and re-tested at one-week intervals.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Getting a score of 6 or above on the Hodkinson Mental Test  Exclusion Criteria:  -Having another chronic disease that can cause pain Having a neurological disease Being blind Having an orthopedic, neurological or mental disability - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 65 Years - StdAgeList: Older Adult