rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
Effect of Electromyostimulation and Strengthening Exercises on Pain, Fatigue and Physical Performance in Motocross Athletes
Status: Not yet recruiting

Motocross, a popular sport, involves riding motorized vehicles on rugged tracks with obstacles. It's physically demanding, with high speeds and a risk of accidents. Grip strength is crucial, especially in the arms and forearms, which are prone to injury. Physiotherapy often employs strength exercises, including electromyostimulation. However, there's little research on their effectiveness for motocross athletes. This study aims to compare electromyostimulation combined with strength training versus strength training alone in relieving pain, fatigue, and improving strength in motocross athletes.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Having at least 5 years of professional motocross training experience Being between 18 and 30 years old Volunteering to participate in the study  Exclusion Criteria:  To be absent from the 6-week EMS and strengthening program for more than 2 consecutive sessions Having suffered any injury that prevents you from training in the last 6 months Being receiving a physiotherapy program other than the protocol to be used in the study - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 30 Years - StdAgeList: Adult
Modified Thoracoabdominal Nerve Plane Block In Living Liver Donors
Status: Not yet recruiting

Ultrasound-guided Modified Thoracoabdominal Nerve Plane Block (M-TAPA) is performed deep into the costochondral aspect at the 9th-10th costal level by injecting local anesthetics deep into the chondrium. It provides blockage of both the anterior and lateral cutaneous branches of the thoracoabdominal nerve. As there are studies showing M-TAPA block to be effective for postoperative analgesia for other abdominal surgeries, its effect on patients undergoing living liver donor surgery has not been studied yet. We hypothesize that M-TAPA block performed in living liver donors would reduce opioid consumption in the first 48 hours after surgery.

Eligibility:
- EligibilityCriteria: Inclusion Criteria: Patients American Society of Anesthesiologists (ASA) classification I- II Scheduled for living liver donation surgery for liver transplantation under general anesthesia  Exclusion Criteria: Patients  with history of bleeding diathesis, receiving anticoagulant treatment, with allergies or sensitivity to drugs used, with an infection on the puncture site who do not accept the procedure or participate in the study - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult
Prognostic Indicators of Gullian-Barre Syndrome
Status: Not yet recruiting

Prognostic indicators of Gullian-Barre syndrome and the predictive factors associated with worse prognosis in the Guillain-Barré syndrome (GBS), which can be helpful to fully evaluate the disease progression and provide proper treatments.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients 2 - 18 years old with guillian barrie syndrome admitted at Assiut university children hospital.  Acceptance to participate in this study .  Exclusion Criteria:  Patients aged less than 2 years and more than 18 years old . Children or Parents who refused to participate in this study. - HealthyVolunteers: No - Gender: All - MinimumAge: 2 Years - MaximumAge: 18 Years - StdAgeList: Child, Adult - StudyPopulation: children with GBS, presenting with weakness, diagnosed on clinical and/or electrophysiological grounds, were enrolled. The enrolled children underwent a detailed clinical-assessment followed by nerve conduction studies. - SamplingMethod: Non-Probability Sample
Comparison Between Drugs for Control of Emetic Attacks During Caesarean Delivery
Status: Not yet recruiting

Single shot spinal anesthesia is widely used for most surgical operations especially in obstetric such as hysterectomy, tubal ligation after vaginal delivery, cesarean and curettage etc.; however, in general, cesarean is considered as the most common indication for spinal anesthesia in pregnant women Intra-operative nausea and vomiting/retching (NVR) may be experienced by 20% to 80% of women undergoing cesarean section (CS) with subarachnoid anesthesia (SA) in the absence of antiemetic prophylaxis.

Different treatment options are available to reduce post operative nausea and vomiting (PONV) so we will make a Comparison between Propofol, Ondansetron and Pregabalin for Control of Emetic Attacks during Caesarean Delivery with Spinal Anesthesia

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age: 21-40 years old. Physical status American Society of Anesthesiologists (ASA)I&II. Body mass index (BMI) < 35&>20 kg/m2. Elective uncomplicated cesarean section under spinal anesthesia.  Exclusion Criteria:  Patient refusal. Patients with known history of allergy to study drugs. Advanced hepatic, renal and respiratory diseases. Psychological and mental disorders. Patient with reduced level of consciousness. Hypertensive, cardiac, and diabetic patients. Patients receiving anticoagulants therapy or suspected coagulopathy. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - MinimumAge: 21 Years - MaximumAge: 40 Years - StdAgeList: Adult
Treatment of Ectopic Pregnancy by Low Dose of Methotrexate
Status: Not yet recruiting

Evaluate the efficacy and safety of the use of low dose regimen of methotrexate in treatment of tubal undisturbed tubal ectopic pregnancy

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  undisturbed ectopic tubal pregnancy Bhcg < 5000 Haemodynamicaly stable Normal liver and kidney functions Commitment for fullow up untill ectopic pregnancy resolvede  Exclusion Criteria:  disturbed ectopic pregnancy Bhcg >5000 Persistent abdominal pain Lactating women women with abnormal liver and kidney functions - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - MinimumAge: 18 Years - MaximumAge: 45 Years - StdAgeList: Adult - StudyPopulation: the study will include women with undisturbed ectopic tubal pregnancy Bhcg < 5000 Haemodynamicaly stable Normal liver and kidney functions Commitment for fullow up untill ectopic pregnancy resolved - SamplingMethod: Non-Probability Sample
A Clinical Trial of TQ05105 Tablets in the Treatment of Chronic Graft-versus-host Disease
Status: Not yet recruiting

This is an open, multi-center clinical study designed to evaluate the efficacy and safety of TQ05105 Tablets in patients with chronic graft-versus-host disease

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Voluntary and signed informed consent, good compliance; Age 18-70 years old; Karnofsky Performance Scale (KPS) ≥60 points; Life expectancy ≥ 6months. Received allogeneic hematopoietic stem cell transplantation; Diagnosis of moderate-to-severe chronic graft-versus-host disease (cGVHD) Received systemic therapies for cGVHD; Stable dose of glucocorticoids, other immunosuppressant therapy received within 2 weeks prior to screening; Absolute Neutrophil Count (ANC) ≥ 1.0×10 9/L ；platelet count (PLT) ≥30×10 9 /L; Hemoglobin ≥80g/L; There were no obvious abnormalities in liver and kidney function and coagulation function; Men and women of childbearing age agree to use contraceptive measures during the study period and within 6 months after the end of the study  Exclusion Criteria:  Currently present or occured other malignancies within 3 years prior to first administration; Known or suspected active acute graft versus host disease (aGVHD); Presence of infection requiring treatment within 7 days prior to randomization; Failed allogeneic hematopoietic stem cell transplantation within 6 months or 2 prior allogeneic hematopoietic stem cell transplants; Use of Janus-activated kinase (JAK) inhibitors, Bruton's tyrosine kinase (BTK) inhibitors, or other, chemotherapeutic agents within 2 weeks prior to randomization; Has a variety of factors that affect oral medications (e.g., inability to swallow, chronic diarrhea, intestinal obstruction, etc; Those who have a history of psychotropic drug abuse and cannot be abstained from or have a mental disorder; Have any severe or uncontrolled serious illness, including but not limited to uncontrolled hypertension, heart disease, hepatitis and epilepsy that require treatment; Have any severe or uncontrolled serious illness, including but not limited to，uncontrolled hypertension heart disease, hepatitis and epilepsy that require treatment; Those who are allergic to the study drug or its components; Participation in other clinical trials or major surgery within 4 weeks prior to the first dose; Subjects judged by the investigator to be unsuitable for enrollment; - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 70 Years - StdAgeList: Adult, Older Adult
Study of ATX-01 in Participants With DM1
Status: Not yet recruiting

The goal of this clinical trial is to test ATX-01 in participants with myotonic dystrophy type 1 (DM1). The main question it aims to answer is if ATX-01 is safe and well tolerated. The trial will compare the safety and tolerability of ATX-01 and a matching placebo.

There will be a single-ascending dose part of the trial and a multiple-ascending dose part. In the single-ascending dose, participants will receive one dose of ATX-01 or placebo. In the multiple-ascending dose part, participants will receive three doses of ATX-01 or placebo.

ATX-01 is a novel anti-miR (synthetic single stranded oligonucleotide) that inhibits a microRNA called miR-23b.

Eligibility:
- EligibilityCriteria: Key Inclusion Criteria:  Participants with a documented clinical diagnosis of DM1 (CTG expansion of >150 repeats in DMPK gene measured in peripheral blood mononuclear cells) Ambulatory, defined as able to complete a 10-meter walk/run test at screening without the use of assistive devices such as canes, walkers, or orthoses, except for ankle-foot orthoses Presence for >3 seconds of grip myotonia as confirmed by a central reader  Key Exclusion Criteria:  Participants with congenital DM1 Medical Research Council Muscle Scale score of less than 4 on ankle dorsiflexion or significant tibialis anterior atrophy that prevents a muscle biopsy Use of mexiletine or other agent for within 21 days or 5 half-lives, whichever is longer, prior to screening - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 64 Years - StdAgeList: Adult
Acute Coronary Syndrome and Acupressure
Status: Not yet recruiting

This study aims to examine the effect of acupressure on physiological parameters and anxiety levels in individuals diagnosed with Acute Coronary Syndrome (ACS).

H1-1: Acupressure applied to individuals diagnosed with ACS has an effect on the level of anxiety.

H1-2: Acupressure applied to individuals diagnosed with ACS has an effect on blood pressure.

H1-3: Acupressure applied to individuals diagnosed with ACS has an effect on heart rate.

H1-4: Acupressure applied to individuals diagnosed with ACS has an effect on respiratory rate.

H1-5: Acupressure applied to individuals diagnosed with ACS has an effect on the pain level.

H1-6: Acupressure applied to individuals diagnosed with ACS has an effect on cortisol levels.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Volunteer to participate in the study,  Those aged 18 and over Able to speak Turkish Diagnosed with ACS for the first time Cardiopulmonary resuscitation not applied No orientation problems (those who score 15 on the Glasgow Coma Scale) Not diagnosed with psychiatric disease No amputation, fistula, lymphedema, neuropathy or hemiplegia in any of the Upper Extremities Those who underwent femoral intervention for CAG procedure Those who have not used any integrative practices based on pressure and stimulation such as acupressure, acupuncture and reflexology in the last month. Vital signs (28) are within normal range:  Blood pressure: 90/60-120/80 mmHg Heart rate: 60-100 min Respiratory rate: 12-18 min  Exclusion Criteria:  Those with arrhythmia (AF, VT etc.) Patients who have previously undergone Coronary Angiography Diagnosed with myocarditis, pericarditis Those who do not take any speed-breaking drugs (beloc, arlec, etc.). Patients who underwent radial intervention for CAG procedure - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Comparison of Neuromuscular and Aquatic Exercise Programs on Fall Risk and Physical Function in Geriatrics
Status: Not yet recruiting

Objective: The aim of this study is to compare neuromuscular and aquatic Exercise programs on fall risk and physical function in geriatrics.

Methods: As a result of the power analysis (G-Power), 36 participants are planned to be included in this study Block randomization will be used to divide participants into 2 groups, each with at least 18 participants: Group 1 (NE Group) and Group 2 (AE Group) (Randomizer.org). NE (Neuromuscular Exercise) group will participate in a 12-week exercise program consisting of sensorimotor system training, postural stability and control, global and local joint stabilization, balance training, muscle strength, breathing, and functional movement patterns.AE (Aqıuatic Exercise) Group will participate in an aquatic exercise program, which includes warm-up, mobility and strength, stretching, and cooling exercises in a 140 cm deep pool with a water temperature of 32 °. Data will be collected using the International Physical Activity Survey Short Form (IPAQ-SF), Montreal Cognitive Assessment Scale (MoCA), Geriatric Pain Measure, Optojump-next (Microgate, Bolzano, Italy), 6-minute Walk Test, 30-second-Sit-to-Stand Test, Four Step Square Test, Berg Balance Scale, Fear of Falling Avoidance Behavior Questionnaire.

Practice Implications: This current study will contribute to the understanding of how neuromuscular exercises affect falls and physical function in geriatrics.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Being able to speak and understand Turkish, Getting a score at least 21 points on the Montreal Cognitive Assessment Scale (MoCA), Being able to walk without using any assistive device, Being able to adapt to the training program and wanting to participate in the study voluntarily  Exclusion Criteria:  Presence of neurological, musculoskeletal, inner ear or eye diseases that will cause functional disability and impaired standing balance, Those who have had changes in their medical treatments in the last 6 months, Those with a history of lower extremity surgery as it may affect balance tests, Volunteers who do not attend at least one of the training and evaluations for any reason. Volunteers who want to leave the study voluntarily. Volunteers who cannot continue working due to any additional disease that develops. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 65 Years - MaximumAge: 85 Years - StdAgeList: Older Adult
Evaluation of the H.O.O.V.E.S. Healing Intensives Program
Status: Not yet recruiting

The aim of this study is to measure the impact of these H.O.O.V.E.S. healing intensives on Veteran participants using several psychological instruments. The investigators are planning to administer the demographic questionnaires and psychological instruments to Veteran participants before the healing intensives. Psychological instruments will be administered immediately pre-intervention, pre- and post-session for each session, post-intervention, 90, 120 and 360 days post-intervention. The primary aim is to assess for statistically significant changes pre- to post session and pre- to post-intervention.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Veterans who have served in the military Must be enrolled in a H.O.O.V.E.S. Healing Intensives Program English speakers - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 120 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Veterans enrolled in a H.O.O.V.E.S. healing intensives program and must have served in the military. - SamplingMethod: Non-Probability Sample
NAPO - Novel Approach for Oligospermia
Status: Not yet recruiting

This randomized controlled trial aims to assess whether treatment with denosumab can improve semen quality in infertile men selected by serum anti-mullerian hormone (AMH) as a positive predictive biomarker, and with severely impaired semen quality (concentrations between 0.01 million/mL to 2 million/mL).

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Infertile men ≥ 18 years and < 60 years of age Sperm concentration ≤ 2 million pr. mL Serum AMH levels ≥28 pmol/L. The participants must have appropriate Danish or English language skills and give written informed consent.  Exclusion Criteria:  Chronic diseases, defined as diagnosis where signs, symptoms, and treatment imply an expected long duration and lack of a cure, such as diabetes mellitus, metabolism disorders, osteoporosis, colitis, etc. Sperm concentration <0.01 million pr. mL Men with current or previous malignancies, or at potential risk of testicular cancer after baseline examination and ultrasound will be excluded. Men with hypocalcemia at baseline, defined as albumin corrected calcium < 2,17 mmol/L or total calcium < 2.14 mmol/L Serum vitamin D (25OHD) levels < 25 nmol/L estimated Glomerular Filtration Rate (eGFR) < 60 mL/min/1,73 m2 Insufficient dental status Vasectomy Hypersensitivity to latex, Denosumab, or to any of the excipients (acetic acid, sodium hydroxide, Sorbitol (E420), Polysorbate 20) will be excluded. Serum FSH <3 IU/L Testis size > 17 mL BMI ≥ 35 kg/m2 - HealthyVolunteers: No - Gender: Male - MinimumAge: 18 Years - MaximumAge: 60 Years - StdAgeList: Adult
A Real-world Study of Octreotide Microspheres in Chinese Patients With Neuroendocrine Tumors
Status: Not yet recruiting

The aim of this multicenter, open-label, observational study is to evaluate the safety and efficacy of octreotide microspheres in the treatment of advanced neuroendocrine tumors in real clinical practice, especially to evaluate the treatment of octreotide microspheres in various subgroups of neuroendocrine tumor patients.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Sign an informed consent form and voluntarily participate in this study; Patients with unresectable or metastatic neuroendocrine tumors confirmed by histopathology. Patients with recurrence and progression after surgery or local treatment can also be included in the study; Age ≥ 18 years old; Treatment with octreotide microspheres.  Exclusion Criteria:  Confirmed pregnant or lactating women; Participating in any research with intervention measures outside of routine clinical practice; Other situations unsuitable for inclusion in the study determined by the researcher. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Patients with advanced neuroendocrine tumors treated with octreotide microspheres will be eligible to participate in the study. - SamplingMethod: Probability Sample
Study of CM310 in Patients With Uncontrolled Seasonal Allergic Rhinitis
Status: Not yet recruiting

Allergic rhinitis (AR) is a non-infectious chronic inflammatory disease of the nasal mucosa mainly mediated by immunoglobulin E after exposure to allergens in atopic individuals. The typical symptoms of AR are paroxysmal sneezing, watery rhinorrhea, itching, and nasal congestion, which may be accompanied by ocular symptoms, including eye itching, tearing, redness, and burning sensation, which are more common in patients with hay fever allergies. Bronchial asthma is associated with bronchial asthma in 40% of patients with AR, suggesting a comorbid feature of allergic disease.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Voluntarily sign the informed consent form.  Exclusion Criteria:  Have any condition that are not suitable for participating in this study. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult
Biceps Tenodesis Alone Versus Biceps Tenodesis and Labrum Repair in Superior Labrum Anteroposterior (SLAP) Lesion Type IV
Status: Not yet recruiting

Aim of this study is comparing results Biceps Tenodesis Alone Versus Biceps Tenodesis and labrum Repair in Superior Labrum Anteroposterior (SLAP) Lesion Type IV

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Traumatic and degenerative etiology. No shoulder deformity . No inflammatory joint disorders. Type of the SLAP is SLAP type IV.  Exclusion Criteria:  History of the disease. Bilateral shoulder. DM . Epilepsy . psychological disturbance. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 50 Years - StdAgeList: Adult
The Effect of Unripe Carob Fruit in Celiac Patients
Status: Not yet recruiting

The aim of this study was to investigate the effects of the consumption of cookies produced by adding the unripe part of carob fruit, which has high insoluble fiber, polyphenol and antioxidant content, on the oxidative parameters (TAS and MDA), intestinal permeability (zonulin, GIP) and microbiota of celiac patients and to develop new products containing unripe carob fruit for celiac patients in this direction.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Have been diagnosed with celiac disease within a maximum period of 1 year, Have not received dietary treatment by a dietitian before Body Mass Index value between 18.5-25.0 kg/m2, Who have consumed carob fruit and have not had any allergies, Signed the Informed Consent Form, Between the ages of 19 and 64, Who has not had gastrointestinal tract surgery, Without mental disorder, Without inflammatory disease, No antibiotics or probiotics for the last 1 month, Not taking prescription drugs and/or fiber supplements, Not taking vitamin, mineral supplements, Not during pregnancy and lactation, Without excessive alcohol consumption (>2 drinks/day)  Exclusion Criteria:  Diagnosed with celiac disease for more than 1 year, Have gastrointestinal diseases other than celiac disease, Have previously received dietary treatment by a dietitian, following a diet other than a gluten-free diet, Body Mass Index values below 18.5 kg/m2 and above 25.0 kg/m2, Who have consumed carob fruit and have had any allergies, Not signing the Informed Volunteer Consent Form, Not between the ages of 19-64, Gastrointestinal tract surgery, With a mental disorder, With inflammatory disease, Taking antibiotics or probiotics for the last 1 month, Taking prescription medication and/or fiber supplements, Taking vitamin and mineral supplements, During pregnancy and lactation, Excessive alcohol consumption (>2 drinks/day) - HealthyVolunteers: No - Gender: All - MinimumAge: 19 Years - MaximumAge: 64 Years - StdAgeList: Adult