rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
Cross Cultural Adaptation, Validity and Reliability Test of the Arabic Version of the Outpatient Physical Therapy Improvement in Movement Assessment Log
Status: Not yet recruiting

Purpose of the study:

To translate, culturally adapt, and to test the validity and reliability of the Outpatient Physical Therapy Improvement in Movement Assessment Log in Arabic speaking language.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Participants are adult outpatients who took at least a month of physiotherapy sessions. Both genders will be included. At least 18 years of age. Participants must be conscious and ambulant. Participants able to read, write Arabic as a mother tongue and understand the instructions, questions in the questionnaire.  Exclusion Criteria:  Participants having the following conditions will be excluded from the study:  Patients who are not able to provide informed consent. Patients who are unable to complete the OPTIMAL instrument. Patients who have a severe cognitive impairment. Patients who are not receiving physical therapy. Patients who are not Arabic-speaking. Patients who have a history of malingering - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Egyptian adults who took at least a month of physiotherapy sessions. - SamplingMethod: Non-Probability Sample
Clinical Observation of Botulinum Toxin A Treatment in the Treatment of Rosacea
Status: Recruiting

the goal of this study is to study the clinical efficacy and safety of botox in the treatment of rosacea.

Eligibility:
- EligibilityCriteria: Inclusion Criteria  Meeting the diagnostic criteria of mild to moderate erythema telangiectasis rosette acne; more than 18 years old; to obey the rules of the treatment in the study, and can be followed up for 12 weeks; informed consent;  Exclusion Criteria:  Had received facial cosmetic surgery or botulinum toxin treatment within 6 months before this treatment; due to systemic diseases such as autoimmune diseases or menopause facial flush; had allergies botulinum toxin; pregnant or breastfeeding; other facial skin or oral disease therapy, including research before 4 weeks rose acne accept other treatment; With basic neuromuscular diseases (such as myasthenia gravis, amyotrophic lateral sclerosis, etc.); All landowners 4 weeks before the study whether any oral aminoglycoside drugs, benzodiazepines drugs or muscle relaxants; .Was removed during treatment observation data is not complete, incomplete treatment and patients can't take medication as prescribed. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 60 Years - StdAgeList: Adult
Lumbar ESPB in Hip Replacement Surgery
Status: Not yet recruiting

In this study, continuous erector spinae plane block (ESPB) will be compared to continuous epidural analgesia in patients undergoing elective hip replacement surgery. Opioid consumption, pain severity, quadriceps femoris muscle strength, ability to walk, and quality of recovery will be evaluated. Moreover, chronic pain severity in months after the hospital discharge will be assessed.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  primary hip replacement surgery due to coxarthrosis anesthetized with spinal technique able to use PCA pump having access to phone  Exclusion Criteria:  patients taking painkillers not related to coxarthrosis; having active cancer, dementia or challenging contact with the patient; suffering from depression or other psychiatric disorders that required antidepressant treatment; consuming alcohol or recreational drug addiction; contraindications to the regional block. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 100 Years - StdAgeList: Adult, Older Adult
Postural and Muscle Fatigue Analysis of Endodontic Residents
Status: Recruiting

Musculoskeletal disorders (MSDs) are a significant occupational health problem for dentists and have been linked to a decline in quality of life, often leading to stress-related illnesses and early retirement. Poor posture, poor movement or imbalances in the neck or shoulders can lead to the three most common pain syndromes in dentistry. The objectives of this study were to evaluate the working position adopted during an endodontic procedure and to determine the perception of symptoms of musculoskeletal disorders in first and second year students of the Master in Advanced Endodontics at the European University of Madrid (UEM), using the standardised Nordic Kuorinka questionnaire supplemented by a form with socio-demographic variables. This study has a descriptive cross-sectional observational design and included 10 students selected by convenience sampling. A video camera was used to record the procedures from three different angles for a maximum of 5 minutes. The information was processed using Microsoft Excel spreadsheet software, and the video recordings were assessed using Rodgers' Muscular Fatigue Analysis (RMFA) and Rapid Upper Limb Assessment (RULA).

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  - Students of the Master's Degree in Endodontics of the European University of Madrid (UEM), who have completed the two years of the annual teaching period of clinical practice.  Exclusion Criteria:  Subjects previously diagnosed with a musculoskeletal disorder. Subjects who had suffered previous trauma affecting the musculoskeletal system. Pregnant women in their third trimester. Subjects who refused to participate. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - StdAgeList: Child, Adult, Older Adult - StudyPopulation: 1st and 2nd year students of the Master's Degree in Endodontics of the European University of Madrid (UEM), who have completed the two years of the annual teaching period of clinical practice during the years 2022/24. - SamplingMethod: Non-Probability Sample
STUDY OF THE EFFECT OF RHYTHMIC AND NON-RHYTHMIC MUSICAL PRIMING ON THE SYNTAX CAPACITY OF PRESBYACOUSTIC OLDER ADULTS
Status: Not yet recruiting

Presbyacusis, or age-related hearing loss, is a public health problem, affecting 20% of men and 30% of women over the age of 70 according to the WHO. In the most incapacitating cases, hearing aids are required. Numerous studies have evaluated the benefits of hearing aids, particularly in terms of improved hearing and quality of life.

However, the specific effect of music on language skills has not yet been studied in hearing-impaired older adults.

In this context, it was decided to study the effect of musical priming on the syntactic abilities of adults aged 70 or older with presbyacusis.

This study is based on the hypothesis that music priming with regular music optimizes the syntax language skills of people with presbyacusis, as has already been proven in adults and normal-hearing children.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  No objection to participation in the study Men and women aged ≥ 70 years Patients diagnosed with presbyacusis (age-related bilateral and symmetrical sensorineural hearing loss, all stages combined), with or without the use of a bilateral hearing aid. If they use a hearing aid: hearing must have an average free-field fitted tonal threshold of 40 dB max and free-field fitted speech discrimination without lip-reading of 90-100% at 60dB in silence. MMSE score ≥ 24/30  Exclusion Criteria:  Person under legal protection (curatorship, guardianship) Person under court order Adult unable to provide consent Person with a neurocognitive disorder (post-stroke, dyslexia, dyspraxia) or neuro-psychiatric disorder (dementia, autism) Severe sensorineural hearing loss with mean free-field threshold > 40 dB and free-field speech discrimination without lip-reading of < 90-100% at 60dB in silence Asymmetrical sensorineural hearing loss due to an additional cause of hearing loss on one side.  Secondary exclusion criteria:  Person with syntax disorder (discovery of sentence comprehension or production disorders during syntax test) - HealthyVolunteers: No - Gender: All - MinimumAge: 70 Years - StdAgeList: Older Adult
Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer
Status: Recruiting

The purpose of this study is to evaluate the efficacy and safety of Zanidatamab plus CisGem (Cisplatin and Gemcitabine) with or without the addition of a programmed death protein 1/ligand-1 (PD-1/L1) inhibitor (physician's choice of either Durvalumab or Pembrolizumab, where approved under local regulations) as first line of treatment for participants with human epidermal growth factor receptor 2 (HER2)-positive biliary tract cancer.

Eligibility:
- EligibilityCriteria: Inclusion Criteria  Histologically- or cytologically-confirmed Biliary Tract Cancer (BTC), including Gallbladder Cancer (GBC), Intrahepatic Cholangiocarcinoma (ICC), or Extrahepatic Cholangiocarcinoma (ECC).. Locally advanced unresectable or metastatic BTC and not eligible for curative resection, transplantation, or ablative therapies. Received no more than 2 cycles of systemic therapy with gemcitabine and a platinum agent with or without a PD-1/L1 inhibitor (physician's choice of durvalumab or pembrolizumab, where approved under local regulations) for advanced unresectable or metastatic disease. HER2-positive disease (defined as IHC 3+; or IHC 2+/ ISH+) by IHC and in situ Hybridization (ISH) assay (in participants with IHC 2+ tumors) at a central laboratory on new biopsy tissue or archival tissue from the most recent biopsy. Assessable (measurable or non-measurable) disease as defined by Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1), per investigator assessment. Male or female ≥ 18 years or age (or the legal age of adulthood per country-specific regulations). Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. Adequate organ function Females of childbearing potential must have a negative pregnancy test result. Females of childbearing potential and males with a partner of childbearing potential must be willing to use 2 methods of birth control.  Exclusion Criteria  Prior treatment with a HER2-targeted agent Prior treatment with checkpoint inhibitors, other than durvalumab or pembrolizumab The following BTC histologic subtypes are excluded: small cell cancer, neuroendocrine tumors, lymphoma, sarcoma, mixed tumor histology, and mucinous cystic neoplasms detected in the biliary tract region. Use of systemic corticosteroids. Brain metastases Severe chronic or active infections History of allogeneic organ transplantation. Active or prior autoimmune inflammatory conditions History of interstitial lung disease or non-infectious pneumonitis. Participation in another clinical trial with an investigational medicinal product within the last 3 months. Females who are breastfeeding Any other medical, social, or psychosocial factors that, in the opinion of the investigator, could impact safety or compliance with study procedures. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
FeelFit: High-intensity Interval Training to Improve Self-reported Physical Fitness in Brain Tumor Patients
Status: Recruiting

The FeelFit study aims to assess the effectiveness of High-Intensity Interval Training (HIIT) in improving self-reported physical fitness in adult brain tumor patients during periods of stable disease, as compared to a waiting-list control group. Furthermore, several secondary and exploratory outcomes will be evaluated. The study is part of the GRIP (GuaRding quality survivorshiP) project, which aims to improve quality of life in brain tumor patients.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  reduced self-reported physical fitness; minimum age of 18 years; diagnosed with a primary brain tumor; stable disease, i.e. no signs of radiological or clinical tumor progression; no oncological treatment for at least two months prior to inclusion; able to speak, read and write in Dutch.  Exclusion Criteria:  Karnofsky Performance Score < 70; already participated in a HIIT program < 1 month prior; contraindication of exercise. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Study to Evaluate the Efficacy and Safety of TEL/AML/CTD in Elderly Patients With Essential Hypertension
Status: Recruiting

This study is to develop a predictive model for cardiocerebrovascular risk factors in elderly patients with essential hypertension with Telmisartan, Amlodipine, and Chlorthalidone Fixed-Dose Combination.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  A patient over 65-year-old with essential hypertension A patient with essential hypertension who require treatment with 3 or more antihypertensive medication, as determined by investigator's decision A patient with no MACCE within 6 months prior to the enrollment A patient who voluntarily signed the informed consent form  Exclusion Criteria:  A patient who participates in clinical trial A patient who are contraindicated for the Truset tablet according to the label. A patient who is unable to complete the study judged by the investigator. - HealthyVolunteers: No - Gender: All - MinimumAge: 65 Years - StdAgeList: Older Adult - StudyPopulation: Patients in General Hospital - SamplingMethod: Non-Probability Sample
Healthy Minds Comparison Study
Status: Not yet recruiting

The goal of this clinical trial is to understand the difference between two versions of the Healthy Minds application, a digital well-being program. The main question it aims to answer is the differences between versions of the Healthy Minds application and their effects on well-being.

Participants will complete a four-week well-being program and complete surveys via an app on their phone. Participants can expect to participate in the study for four months.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age ≥18 years Elevated symptoms of depression and anxiety Proficient in English Access to a smartphone  Exclusion Criteria:  Prior experience with meditation generally Prior use of the Healthy Minds application History of psychosis or mania Alcohol and/or substance use disorder - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Nasal Antisepsis for C. Auris Prevention
Status: Recruiting

This is a randomized, controlled, open-label trial of effect of 10% povidone iodine intranasal antisepsis on the detection of Candida auris.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  History of C. auris colonization or infection Patient in a participating facility  Exclusion Criteria:  History of severe allergy to iodine-based products, defined as anaphylaxis or rash Currently breastfeeding or pregnant Non-English language speaking - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Xerostomia-optimised IMRT Versus Standard IMRT in NPC
Status: Recruiting

This is a multi-center, non-inferiority, open-label, randomized controlled phase III clinical trial in primary diagnosed nasopharyngeal carcinoma (NPC) patients without distant metastasis. This study aims to compare the regional control, survival outcomes, radiation-related toxicities, and quality of life (QoL) of xerostomia-optimized intensity-modulated radiotherapy versus standard intensity-modulated radiotherapy in NPC patients

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Newly histologic diagnosis of nasopharyngeal non-keratinizing carcinoma (WHO II/III); All genders, range from 18-70 years old; ECOG score 0-1; Clinical stage I-IVa (AJCC/UICC 8th); Not received radiotherapy, chemotherapy and other anti-tumor treatment (including immunotherapy); No contraindications to chemotherapy or radiotherapy; Adequate organ function: white blood cell count ≥ 4×109/L, neutrophile granulocyte count ≥ 1.5×109/L, hemoglobin ≥ 90g/L, platelet count ≥ 100×109/L; alanine aminotransferase or aspartate aminotransferase < 2.5×upper limit of normal; blood urea nitrogen or creatinine ≤ 1.5×upper limit of normal or endogenous creatinine clearance ≥ 60ml/min (Cockcroft-Gault formula); Sign the consent form.  Exclusion Criteria:  Level II involvement with extracapsular extension (ECE), and/or had a maximum nodal axial diameter (MAD) of greater than 3cm in level II ;  -≥4 nodal regions of ipsilateral neck involvement;  Radiologically suspicious or confirmed involvement in level II area between skull base and the lateral process of C1; Parotid lymph node and/or parotid gland involvement; History of parotid disease or surgery; Previous malignancy or other concomitant malignant disease; Pregnancy or lactation. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 70 Years - StdAgeList: Adult, Older Adult
EW and Self-Guided PST in Cancer Survivors and Caregivers
Status: Recruiting

To assess the feasibility and acceptability of expressive writing + problem solving therapy (EW+PST) among cancer survivors and informal caregivers

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Cancer diagnosis of any type OR informal caregiver (family member, friend, and/or spouse who provides the majority of caregiving) of someone with cancer Patient of Virginia Commonwealth University (VCU) Massey Cancer Center OR informal caregiver (family member, friend, and/or spouse) of a VCU Massey Cancer Center patient  Exclusion Criteria:  Physical inability to write Non-English speaker/writer Inability to consent to study participation - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
The Effect of Visual and Audio Stimulus Offered to Father-to-be
Status: Recruiting

It was aimed to evaluate the effect of visual and auditory stimuli presented to father candidates on postpartum breastfeeding success of mothers, perception of spousal support and postpartum depression. The study, which was carried out in a randomized controlled experimental design, consists of nulliparous pregnant women and their spouses who came to the relevant health center for prenatal control between May 2023 and May 2024. In the study, 132 pregnant women (Experimental group 1:44, Experimental group 2:44, control group:44) were recruited with a priori power analysis. In the study, women and their spouses were assigned to the experimental and control groups by randomization. For randomization, single-group columns between 1-165 were created in the system using the Random Integer Generator method in the Numbers subheading of the random.org website. Considering the numbers 1, 2 and 3 in the column, nulliparous pregnant women coming to the polyclinic were randomly assigned to these numbers. Which numbers constitute which group was determined by drawing lots at the beginning of the research. In data collection, Introductory Information Form for women, Women's Perceived Spousal Support Scale in Early Postpartum Process, Breastfeeding Self-Efficacy Scale-Short Form, Breastfeeding Adaptation Scale and Edinburgh Postpartum Depression Scale; Introductory Information Form for men, Fathers; Breastfeeding Attitude and Participation Scale and Edinburgh Postpartum Depression Scale (for Men) were used. Data; It was evaluated in the SPSS program.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Criteria for inclusion of pregnant women in the study:  Being literate Being nulliparous 32-35. weeks of pregnancy between Having a single fetus There is no obstacle to vaginal birth There is no condition that prevents breastfeeding Being open to communication Volunteering to participate in the research  Criteria for inclusion of fathers in the study:  Being literate Being over 18 years of age Being a father for the first time Using a smartphone Being open to communication Volunteering to participate in the research  Exclusion Criteria:  Criteria for excluding pregnant women from the study:  Illiteracy Having a high risk pregnancy Having a diagnosed psychiatric disease  Exclusion criteria for women in the postpartum period from the study:  Having given birth prematurely Having had a caesarean section Development of complications in the mother and/or baby after birth A condition that prevents breastfeeding in the mother and/or baby  Criteria for not including fathers in the study:  Illiteracy Being under 18 years of age Having a diagnosed psychiatric disease - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - GenderBased: Yes - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Pupil-Indexed Noninvasive Neuromodulation
Status: Not yet recruiting

Vagus nerve stimulation (VNS) is thought to activate neural pathways that release chemicals which promote plasticity and learning. Previous work has shown that the auricular branch of the vagus nerve innervates landmarks on the external ear. Work from the PI's laboratory has shown that electrical current applied to the external ear modulates physiological indexes of brain states implicated in the therapeutic effects of VNS. The broad objective of this project is to better understand physiological mechanisms modulated by auricular stimulation to support possible therapeutic effects in the form of motor learning.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  ALL PROSPECTIVE SUBJECTS:  18-75 years of age  PROSPECTIVE SUBJECTS DIAGNOSED WITH STROKE:  Diagnosis of a single stroke resulting in hand impairment Diagnosis of stroke at least six months prior to the time of participation  Exclusion Criteria:  ALL PROSPECTIVE SUBJECTS:  History of vestibular disorders or dizziness Difficulty maintaining alertness and/or remaining still Pregnant or expecting to become pregnant Diagnosis of neurological and/or musculoskeletal disorder(s) (other than stroke) that affect movement Ocular disease and/or impairment in more than one eye History of seizure and/or epilepsy Implants, devices, or foreign objects in the brain/body that are incompatible with MRI Body size that is incompatible with MRI scanner dimensions  Anyone already enrolled and actively participating in another greater than minimal risk study.  PROSPECTIVE SUBJECTS DIAGNOSED WITH STROKE:  Other impairments secondary to stroke (e.g., attention, cognition, etc.) that would interfere with the ability to understand study goals or follow simple instructions, as judged by the investigators. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult