rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
The Comparison of Different Root Coverage Techniques Using the Anatomical Recession Area Approach
Status: Not yet recruiting

The goal of this clinical trial is to compare the effectiveness of two treatments for gingival recession. The main questions it aims to answer are:

Which treatment method, Coronally Positioned Flap with Connective Tissue Graft or Modified Coronally Advanced Tunnel with connective tissue graft, is more effective in treating gum recession? How does the Anatomical Recession Rate, a new measurement technique, help in evaluating the success of these treatments?

The patients will be treated with coronally advanced flap or modified coronally advanced tunnel + connective tissue graft to see which method is more effective in reducing gum recession, as measured by using anatomical recession rate.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Participants aged 18 to 60 years. Individuals with the gingival recession of Miller Class I, II, or III in at least one tooth in the anterior mandibular or maxillary region. Participants must have at least 1 mm of keratinized tissue width around the affected tooth/tooth and be in good general health. Ability to provide informed consent for participation in the study.  Exclusion Criteria:  Individuals with uncontrolled systemic diseases that could impact periodontal healing (e.g., diabetes mellitus, cardiovascular diseases). Current smokers or those who have quit smoking less than 6 months before the study. Women who are pregnant or breastfeeding. Participants who have received periodontal or gingival recession treatment in the study area within the last year. Presence of acute periodontal or dental infections requiring immediate treatment, or extensive caries affecting the study teeth. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 60 Years - StdAgeList: Adult
Prophylactic Double Thermal Ablation and Complete Closure After Endoscopic Mucosal Resection of Large Non-Pedunculated Colorectal Polyps: A Randomized Controlled Trial
Status: Not yet recruiting

Large (≥20mm) colorectal polyps often harbor areas of advanced neoplasia, making them immediate colorectal cancer (CRC) precursors. Such polyps have to be completely removed to prevent CRC and to avoid surgery and/or adjuvant therapy. The laterally spreading lesions (LSLs) are removed via endoscopic mucosal resection (EMR). However, recurrence is common. Recent studies have found that the use of hybrid argon plasma coagulation (h-APC) for the ablation of the margin and base of resection post-EMR could significantly reduce the recurrence rate, and complete closure of the post-EMR defect can prevent other adverse pre- and post-procedure outcomes such as bleeding.

We hypothesize that performing hybrid argon plasma coagulation (h-APC) margin and base ablation post-EMR for large (≥20mm) colorectal LSLs will demonstrate a lower recurrence rate compared to Snare Tip Soft Coagulation (STSC) margin ablation. We also hypothesize that performing complete closure of the EMR defect will result in lower rates of adverse events compared to cases where no defect closure is performed.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  adult ≥18 years old patients undergoing EMR for a large (≥20mm) colorectal LSL patients providing written and informed consent for study participation.  Exclusion Criteria:  inflammatory bowel disease; non-elective colonoscopy; poor general health (American Society of Anesthesiologists classification >III); coagulopathy or thrombocytopenia (international normalized ratio ≥1.5 or platelets <50 x 109/L); pedunculated polyps (Paris class Ip, Isp); overt signs of deep submucosal invasive cancer (JNET 3); biopsy proven invasive carcinoma in a potential study polyp. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
A Multicenter Clinical Study of Yijing Keli in the Treatment of Ovarian Aging
Status: Recruiting

Ovarian aging (OA) seriously affects the physical and mental health of women. Nowadays, Chinese herbs have huge appeal and potential in treating OA. We have created a new Chinese herbal combination Yijing Keli, whereas its safety and efficacy still need to be validated. Hence, we will perform a population-based, multicenter study to confirm the safety and efficacy of Yijing Keli in therapy of OA. We aim to provide a solid evidence for TCM in therapy of OA.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  The age range of patient is 18-55 years old. The diagnostic criteria for ovarian aging. Sign the informed consent form.  Exclusion Criteria:  Patient is known to be allergic or unsuitable for the Chinese herbal compound. Women who are pregnant and lactating. Abnormal uterine bleeding, except ovulation disorders. Women is taking hormone drugs and has stopped taking them within 3 months; Women with endometriosis, myadenosis, submucosal fibroids or the size of non- submucosal fibroids is more than 4 cm. The nature of pelvic mass is unknown. Women with polycystic ovary syndrome, hyperprolactinemia, hyperandrogenemia, diabetes, thyroid and adrenal dysfunction and other endocrine diseases affecting ovulation. Patients with serious primary diseases such as cardiovascular, liver, kidney, lung, biliary, hematopoietic system (Hb<90g/L) and malignant tumor, and psychiatric patients. Patients are participating in other clinical trials or have participated in other clinical trials within the last month. Unsuitable for the study evaluated by the investigator. - HealthyVolunteers: No - Gender: Female - MinimumAge: 18 Years - MaximumAge: 55 Years - StdAgeList: Adult
Role of Cervical Spine Mobilization on Lateral Epicondylitis
Status: Recruiting

The study's primary goal is to examine the effectiveness of Mulligan's technique in reducing hyperalgesia in lateral epicondylitis, focusing on cervical spine, while also investigating its influence on central sensitization in relation to lateral epicondylitis.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  a positive Maudsley's test and Cozen's test, positive Spurling and axial distraction tests limited range of motion of the cervical spine a positive upper limb tension test (ULTT) middle-aged individuals (40-60 years old).  Exclusion Criteria:  participants with any pathologies participants involved in other studies patients undergoing corticosteroids treatment physical therapy sessions, or surgical interventions for elbow or cervical spine issues within the past year individuals afflicted by inflammatory, infectious, or systematic diseases participants experiencing bilateral elbow pain or tumor diseases are excluded. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 30 Years - MaximumAge: 50 Years - StdAgeList: Adult
Effects of the Singapore Youth Shoulder Overuse Injury Prevention Program Among Youth Volleyball Athletes in Singapore
Status: Not yet recruiting

The Singapore Youth Shoulder Overuse Injury Prevention Program (YoSO-IPP) includes an exercise segment and an education segment. This study will (1) assess the effects of the exercise segment, and (2) assess the effects of the education segment among youth volleyball athletes using a randomized controlled trial over 12 weeks. Performance outcome measures of shoulder eccentric external rotation strength, shoulder internal rotation range of motion, and thoracic rotation range of motion will be used to assess the effects of the exercise segment. Knowledge scores via an online questionnaire will be used to assess the effects of the education segment.

Hypothesis: The YoSO-IPP will have an effect on shoulder eccentric external rotation strength, shoulder internal rotation range of motion, and thoracic rotation range of motion and on knowledge scores.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  12 to 18 years old youth athlete; in the sport of volleyball; trains with an aim to compete; currently NOT undergoing any shoulder or elbow overuse injury prevention program  Exclusion Criteria:  Below 12 and above 18 years old; not in the sport of volleyball; trains without an aim to compete; currently undergoing a shoulder or elbow overuse injury prevention program - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 12 Years - MaximumAge: 18 Years - StdAgeList: Child, Adult
The Effect of Electro-fetal monıtorısıon Sound on Anxiety, paın and Postpartum Bonding at the First Phase of Delivery
Status: Recruiting

University of Health Sciences, Istanbul Umraniye training and Research Hospital, Clinic of Obstetrics and gynecology, birth, maternity and Child Health Hospital, Aydın to the clinic, pregnant women, pregnant women in active labor act, and received acceptance to delivery to the fetal heart sound by existing tripped; fetal heart sounds of pregnant women, anxiety, pain and the birth in order to determine the effect of connecting the end of the level will be conducted. The study will guide midwives in reducing the anxiety or pain of pregnant women.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Who are december the age range of 18- 35, The least literate, Which is the primiparous, who is at the 38-42 week of gestation With a single pregnancy in the vertex position, Who does not have a systemic disease that will interfere with normal delivery (gestational diabetes, preeclampsia, etc.), Who is in the active phase of labor * Pregnant women who have agreed to participate in the study and received informed consent will be included in the study  Exclusion Criteria:  37. week 42. not between the weeks dec It is a multipart, Anyone who has any problems with communication, Who has ceased to be involved in the study,  An unexpected complication develops (cesarean section of the pregnant woman, development of fetal distress in the fetus, etc.).  Oxytocin induction is applied Pregnant women who have been given pain medication (Aldolan, diazem) are - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - MinimumAge: 18 Years - MaximumAge: 35 Years - StdAgeList: Adult
Influence of an Inspiratory Muscle Fatigue Protocol on Healthy Youngs on Respiratory Muscle Strength, Vertical Jump Performance and Muscle Oxygen Saturation
Status: Not yet recruiting

Respiratory muscle training represents an effective method increasingly utilized in both sports and healthcare domains, employing various devices, among which threshold devices are prominent. The aim of this study is to determine the relationship between inspiratory muscle fatigue and muscular strength in lower limbs, in both healthy and pathological subjects, as well as the association between such fatigue and other variables, including maximal inspiratory pressure and muscle tissue oxygen levels.

According to our hypothesis, the execution of a protocol inducing inspiratory muscle fatigue in healthy youngs could influence muscular strength, exercise capacity and muscle tissue oxygenation.

In this study, subjects will be divided into three groups: experimental group , activation group and control group.

Measurements of variables, such as maximal inspiratory pressure, peripheral muscle tissue oxygen levels, diaphragmatic strength (ultrasound image) and vertical jump performance, will be conducted.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Aged between 18-45 years. Non-smoker. Engaged in sports activity at least 3 times a week for a minimum of one year.  Exclusion Criteria:  Having a medical condition that impedes engaging in physical activity. Individuals with compromised cognitive capacities. Subjects with any chronic disease (cardiorespiratory, neurological, metabolic, oncological, etc.). Subjects with tympanic perforation or middle-inner ear pathology. Subjects who have undergone lower limb surgery within the past 12 months. Subjects experiencing an active episode of lower limb pain. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 45 Years - StdAgeList: Adult
Effect of Pilates Exercises on Forward Head Posture in Breastfeeding Women
Status: Not yet recruiting

Musculoskeletal postural issues stemming from infant care positions can exert a significant impact on the cervical, thoracic, and lumbar spine. These positions can induce mechanical alterations in the spine's natural curvature, potentially resulting in long-term deformities in postnatal women such as forward head posture (FHP), ultimately contributing to physical disability over the long term.so, The purpose of this study is to determine the effect of Pilates exercises on FHP in breastfeeding women.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  All women are breastfeeding and will have FHP. They are between six to twelve months post-delivery. They should have a single, healthy, and full-term baby without complications. Their body mass index (BMI) will not exceed 30 Kg/m2. Their parity will range from 2 to 3 children. They are housewife.  Exclusion Criteria:  Cancer of the breast or the surrounding area, any previous breast or chest surgery, breast infection, retracted, cracked, inflamed or inverted nipples. Any cardiorespiratory disease, anemia, or diabetes mellitus. Recent fracture or surgery of the cervical spine or shoulder. History of physical and mental diseases. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - MinimumAge: 20 Years - MaximumAge: 35 Years - StdAgeList: Adult
Self-Compassion to Enhance the Well-Being of Caregivers of Children With Physical Disabilities
Status: Not yet recruiting

The goal of this clinical trial is to test the feasibility, acceptability and preliminary social/emotional well-being outcomes of a tailored, online self-compassion-based resilience course for caregivers of children with physical disabilities. The main questions it aims to answer are:

Is the online resilience course feasible and acceptable to caregivers of children with physical disabilities?
Is participation in the resilience course associated with improvements in caregiver stress, anxiety, depression, burden, self-compassion, and/or life satisfaction?

Participants will complete a screening, a verbal consent process and an electronic pre-course survey. Then, they will participate in a 6-session weekly online course with other caregivers and led by a certified Mindful Self-Compassion instructor. The course has been co-designed with caregivers and includes skills for recognizing and coping with difficult emotions while connecting with others who have similar caregiving experiences. After the course, participants will repeat the electronic survey and will provide feedback on the course during a live,online feedback session.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  At least 18 years old Reads and speaks in English Is the primary caregiver to a child aged 2-17 with a chronic physical disability that requires assistance in at least 2 functional areas (e.g., mobility, self-care, communication)  Exclusion Criteria:  No access to the internet/Zoom Hospitalized in the last year for mental health treatment Has a history of psychosis (e.g., schizophrenia) - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Effect Of Resistive Exercises Versus Aerobic Exercises On Varicose Veins In Postmenopausal Women
Status: Recruiting

The purpose of this study will be to determine the effect of resistive exercises on varicose veins in postmenopausal women, the effect of aerobic exercise on varicose veins in postmenopausal women and to compare between the effect of resistive exercise versus aerobic exercise on varicose veins in post menopausal women.

Eligibility:
- EligibilityCriteria: Inclusion criteria:  All women suffering from varicose veins. Their age will range from 50 to 65 years. Their body mass index will range from 25 to 29.9 kg/m2. Voluntary acceptance of participation in the study.  Exclusion Criteria:  Had history of serious vascular disease as deep venous thrombosis. Sensory deficient Any dermatological condition that interferes with the procedure. Any musculoskeletal or neurological disorders. Acute or healed ulcer wounds. Any heart disease or pulmonary disease. - HealthyVolunteers: No - Gender: Female - GenderBased: Yes - MinimumAge: 50 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult
Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction II
Status: Not yet recruiting

Rose Bengal Electromagnetic Activation with Green light for Infection Reduction II (REAGIR II) is a randomized, double-masked feasibility study. The purpose of this study is to determine differences in 6-month visual acuity between medical antimicrobial treatments alone versus antimicrobial treatment plus cross-linking with rose Bengal (RB-PDT).

Patients presenting to one of the Aravind Eye Hospitals in India or to the Federal University of São Paulo ophthalmology clinic in Brazil with smear-positive and/or culture positive typical (I.e. non-Nocardia or Mycobacteria) bacterial corneal ulcers and moderate to severe vision loss, defined as Snellen visual acuity of 20/40 of worse, will be eligible for inclusion. Those who agree to participate will be randomized to one of two treatment groups:

Group 6, RB-PDT Plus Early Steroids: topical 0.5% moxifloxacin plus topical difluprednate 0.05% plus RB-PDT
Group 7, Sham RB-PDT Plus Early Steroids: topical 0.5% moxifloxacin plus topical difluprednate 0.05% plus sham RB-PDT

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Corneal ulcer that is smear positive and/or culture positive (within 24 hours) for typical bacteria (i.e. non-Nocardia or Myobacteria) Moderate to severe vision loss, defined as Snellen visual acuity of 20/40 (6/12) or worse Corneal thickness ≥350 µm, as measured on AS-OCT Age over 18 years Basic understanding of the study as determined by the physician Commitment to return for follow up visits  Exclusion Criteria:  Evidence of concomitant infection on exam, gram stain, or confocal microscopy (i.e. herpes, both bacteria and acanthamoeba on gram stain) Impending or frank perforation at recruitment Involvement of sclera at presentation Presence of desmetocele at recruitment Non-infectious or autoimmune keratitis History of corneal transplantation History of intraocular surgery within the last three months* Pinhole visual acuity worse than 20/200 in the unaffected eye Participants who are decisionally and/or cognitively impaired - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Psychological Effects of a Set of Functional Fragrances
Status: Not yet recruiting

The goal of this clinical trial is to test the effectiveness of an intervention designed to improve wellness through aromatherapy. The main question it aims to answer is whether this intervention can deliver beneficial psychological effects on stress, anxiety and mood, as well as overall well-being.

Participants will receive a bottle with a no/neutral odor or an essential oil (or a blend of essential oils) for home administration and will be asked to complete a series of scales pre and post self-administration twice one week apart.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Adults (at least 18 years old)  Exclusion Criteria:  Allergies to Essential Oils Medical conditions that could have an effect on sense of smell - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult
Treatment of Fibromyalgia With the FibroNova Neuromodulation Device
Status: Not yet recruiting

Fibromyalgia (FM) is a chronic disorder that affects the musculoskeletal system, causing widespread pain, tenderness, and fatigue. It is estimated to affect 1-5% of the population. The primary symptom of fibromyalgia is widespread pain throughout the body, accompanied by tenderness and sensitivity to pressure.

Pharmacological treatments include drugs such as antidepressants, anticonvulsants, and painkillers. Another treatment option for fibromyalgia is the use of devices such as Quell. Other non-pharmacological treatment options for fibromyalgia include cognitive-behavioral therapy (CBT), biofeedback, and relaxation techniques.

Remote Electrical Neuromodulation (REN) is a non-pharmacological technology that induces subthreshold, non-painful neurostimulation signals that activate an endogenic pain-management system termed Conditioned Pain Modulation (CPM), to produce generalized pain relief in remote body areas. Multiple studies have shown that REN is safe and effective for the acute treatment of migraine in adults and adolescents, as well as migraine prevention.

The current study examines the safety and efficacy of REN technology, implemented via the FibroNova device for treating fibromyalgia pain and related symptoms.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patient age is 18-70. Meets ACR 2010 Diagnostic Criteria for FM. Naïve to Nerivio and to FibroNova devices. Possesses the basic cognitive and motor skills needed to operate his/her own smartphone. Must be able and willing to comply with the protocol. Must be able and willing to provide written informed consent.  Exclusion Criteria:  Change in prescribed medications for pain and/or fibromyalgia in the two months prior to enrolment. Pregnant or lactating. Has other significant comorbidities or pain problem(s) or undergoing specific therapies that in the opinion of the investigator may confound the study assessments.(e.g. active inflammatory joint disease, including spondyloarthropathy, or active malignancy, excluding Basal cell carcinoma). Newly diagnosed with fibromyalgia (under six months). Is currently implanted with an electrical and/or neurostimulation device (e.g., cardiac pacemaker or defibrillator, vagus nerve neurostimulator, deep brain stimulator, spinal stimulator, bone growth stimulator cochlear implant, Sphenopalatine ganglion stimulator bladder stimulator or Occipital nerve stimulator). Known uncontrolled epilepsy. Active substance use disorder that could interfere with study participation. Use of opioids during the 2 months prior to enrolment. Has undergone nerve block (occipital or other) during the 2 months prior to enrolment. Patients with severe depression, and/or suicidality Is participating in any other clinical study. Use of a neuromodulation device specifically indicated for FM ( e.g.Quell ) currently or in the 2 months prior to enrolment. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 70 Years - StdAgeList: Adult, Older Adult
Impact of Visceral Manipulation Versus Integrated Neuromuscular Inhibition Technique in Shoulder Impingement Syndrome
Status: Not yet recruiting

This study will be conducted To evaluate the effect of Visceral Manipulation versus Integrated Neuromuscular Inhibition Technique on the upper fiber of trapezius on pain intensity, pain threshold, shoulder range of motion, and function in shoulder impingement syndrome

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  -active myofascial trigger points in the upper trapezius muscle, and chronic Pain lasting more than 12 weeks BMI between 25 and 30 Kg/m².  Exclusion Criteria:  a previous fracture in the cervical spine or shoulder surgery acute inflammatory condition. Malignant tumor. Multiple osteophytes. Cervical posture abnormalities. Osteoporosis. - HealthyVolunteers: No - Gender: All - MinimumAge: 20 Years - MaximumAge: 40 Years - StdAgeList: Adult