rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
A Prospective Study on Esophagogastrostomy by an Innovative Surgical Technique
Status: Recruiting

This is a single-center, open-label, Phase Ib/II study aiming to assess the perioperative safety and postoperative outcomes of a novel surgical technique in treating primary adenocarcinoma located in the upper 1/3 of the stomach or gastroesophageal junction (Siewert II or III).

The study will enroll 30 patients who will undergo totally laparoscopic proximal gastrectomy with esophagogastrostomy by fissure technique. Clinical data will be collected to evaluate perioperative safety. Patients will be followed for at least 3 months, during which endoscopy will be performed to analyze occurrences and reasons for anastomotic-related complications. Additionally, the quality of life after surgery will be evaluated by QLQ-C30 and QLQ-STO22.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age between 18 and 75 years old; Pathologically confirmed as adenocarcinoma; Primary tumor located in the upper 1/3 of the stomach or the gastroesophageal junction (Siewert II or III); If it is adenocarcinoma of the upper 1/3 of the stomach, cT1N0M0 should be met. For gastroesophageal junction adenocarcinoma, cT1-2N0M0 should be met, and clinical judgment should indicate no distant lymph node metastasis around the stomach. Bilateral resection margins should be greater than 2 cm, and more than half of the residual stomach should be preserved. No history of upper abdominal surgery (excluding laparoscopic cholecystectomy). No preoperative comprehensive treatments such as chemotherapy, radiotherapy, targeted therapy, immunotherapy, etc. Preoperative ECOG (Eastern Cooperative Oncology Group) score of 0/1. Preoperative ASA (American Society of Anesthesiologists) score I-III. Good function of important organs. Signed informed consent.  Exclusion Criteria:  Preoperative assessment indicating cT4b or Bulky lymph nodes enlargement or distant lymph nodes metastasis; Pregnant or lactating women; Patients with severe mental illness; Preoperative temperature ≥38°C or infectious diseases requiring systemic treatment; Severe respiratory diseases, with FEV1 < 50% of predicted value; History of other malignant tumors in the past 5 years; Severe liver or kidney dysfunction; Unstable angina or myocardial infarction within the last 6 months; History of stroke or cerebral hemorrhage within the last 6 months (excluding old infarcts); Systemic use of glucocorticoids within the last 1 month; Emergency surgery required due to complications of gastric cancer (bleeding, perforation, obstruction); Patient has participated in or is currently participating in other clinical trials (within the last 6 months). - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult
Understanding Adaptive Immune Response After COVID-19 Vaccination Boosters to Improve Vaccination Strategies in Vulnerable Groups.
Status: Recruiting

This is an experimental study without drug and device, non-profit, single-center.

The general objective of the project is to study how the adaptive immune response evolves against SARS-CoV-2 with repeated vaccination boosters and infections also in relation to the evolution of variations. This study will be relevant to frail populations who are the main targets of repeated vaccinations. Our project will benefit from the availability of a highly cohort characterized of vaccinated people, including cancer patients and elderly people, with prospective collection of samples for an in-depth evaluation of the evolution of the immune response with repeated exposure to doses of infection or vaccine. As part of the study, analyzes will be carried out on samples of patients enrolled in a manner prospective at the oncology departments of the IRCCS (Medical Oncology, Department of Radiotherapy advanced oncology and nuclear medicine) and elderly patients residing in retirement homes of the IRCCS. Patients will also be asked for consent to store any residual samples in the Tropica DITM Biobank.

Eligibility:
- EligibilityCriteria: Cancer patients  Inclusion criteria:  Age> 18 years. Solid tumor diagnosis [I, II, III, IV stage,]. Vaccinated with anti-SARS-CoV-2 vaccine or/and having history of past SARS-CoV-2 infections. Signed informed consent.  Exclusion criteria  Age < 18 years. Absence of signed informed consent.  Elderly subjects  Inclusion criteria:  Age> 70 years. Vaccinated with anti-SARS-CoV-2 vaccine or/and having history of past SARS-CoV-2 infections. Signed informed consent.  Exclusion criteria  Age < 70 years. Absence of signed informed consent. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Vibrotactile Feedback Belt in Patients With Unilateral Vestibular Hypofunction (UVH)
Status: Not yet recruiting

The goal of this clinical trial is to study the impact of a continuous vibrotactile feedback belt on balance, (fear of) falling, fatigue and overall functioning in participants with chronic disabling unilateral vestibular hypofunction.

The main questions it aims to answer are: • does wearing a vibrotactile feedback belt during waking hours for a week improve sense of balance and mobility, fear of falling, fatigue and overall functioning • does wearing a vibrotactile feedback belt influence static and dynamic balance and gait performance during balance and gait testing.

Participants will goes through different phases in an randomized order; a baseline phase, a sham phase (i.e., wearing the BalanceBelt while it is switched off) and an intervention phase (i.e., wearing the BalanceBelt while it is switched on).

It is expected that, just as with patients with bilateral loss of the balance organ, patients with a unilateral loss will also benefit from the BalanceBelt.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Diagnosed with severe unilateral vestibular dysfunction (i.e., a gain below 0.6 of the affected side and a gain between 0.8 and 1.1 of the contralateral side measured by the video-Head Impulse Test (vHIIT)). Duration of dizziness complaints >3 months (i.e. chronic dizziness). Self-reported imbalance with a fear of falling and/or actual falls. Is able to walk (with or without a walking aid). Self-reported overall Mobility and Balance Score (MBS) of 3-5 points Motivated to try the BalanceBelt. Provides written informed consent.  Exclusion Criteria:  Age < 18 years Presence of neurological, psychiatric or orthopaedic disorders, Persistent postural-perceptual dizziness (PPPD), reduced proprioceptive sensitivity or impaired vision which influences the postural stability. Not able to understand instructions and questionnaires in Dutch Not able/willing to visit Gelre Hospital Apeldoorn for necessary visits. Wheelchair bound at home - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
The Effect of Structured Digital-Based Education Given to Nursing Students
Status: Recruiting

Turkey is a risky country in terms of disasters. Preparedness and awareness for all disasters affecting the whole world gain value. Disaster literacy is an important approach to evaluating disaster preparedness and awareness processes. Disaster literacy is defined as the ability of an individual to access, read, understand, and use the information necessary to make informed decisions and follow instructions in the context of mitigation, preparation, response, and recovery during a disaster Disaster literacy needs to be increased to raise awareness among individuals and minimize disaster risk. Along with the awareness studies, it is also important to identify the disaster preparedness belief in order to encourage individuals to change potentially harmful behavior. Belief in disaster preparedness; It may vary according to the perception of experiencing a disaster, the perceived severity of the disaster, the benefits of being prepared for a disaster, the perceived barriers to being prepared for a disaster, being prepared, and the individual's belief in his or her ability to cope with a disaster. It may be useful to determine both disaster preparedness beliefs and disaster literacy levels of individuals at the social level. It is predicted that when multiple interventions are brought together in the learning process, there will be a faster and more lasting effect. In this study, which aims to use education and information technology together, a structured digital-based educational intervention is planned. The intervention program was structured by taking advantage of both the advantages of the digital world and active learning methods in order to keep the student active. The program is eight weeks and consists of seven dimensions and the purpose of the program is based on accessing information, understanding, information, making decisions, and applying information. The planned study aimed to determine the effect of structured digital-based education given to university students studying in the nursing department on their disaster literacy and disaster preparedness belief levels.

Eligibility:
- EligibilityCriteria: Inclusion criteria  To be enrolled in the nursing programme Ability to speak and understand Turkish Speak English at least at beginner level To have signed the informed consent form  Exclusion criteria  Having previously participated in any disaster training programme Failure to attend the eight-week digital-based disaster training programme twice in a row - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
The Effect of Exercise and Music on Sleep, Quality of Life and Emotional State in Children With Epilepsy
Status: Recruiting

This study was planned as a randomized controlled experimental study with a pretest-posttest design to determine the effect of parental supervision and video-guided progressive relaxation exercise (PRE) and music recital on sleep, quality of life and emotional states in children with epilepsy aged 9-16 years. The main questions it aims to answer are as follows:

According to the evaluation of children with epilepsy, does the progressive relaxation exercise applied to children have an effect on sleep, quality of life and emotional states? According to the evaluation of children with epilepsy, does music recital applied to children have an effect on sleep quality of life and emotional states? The study consisted of 45 children (15 children in the progressive relaxation exercise group, 15 children in the music recital group and 15 children in the control group). Ethics committee approval, permission from the institutions and informed consent of the children were obtained for the conduct of the study. A value of p<0.05 was considered statistically significant in data analysis.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Between the ages of 9-16, Does not have a chronic or genetic disease other than epilepsy, No mental, visual or hearing impairment, Having a mother who is at least a primary school graduate, Both he and his mother are open to communication and cooperation, Children who both themselves and their mothers volunteer to participate in the research and give verbal and written consent.  Exclusion Criteria:  Not between the ages of 9-16, Having a chronic or genetic disease other than epilepsy, Mentally, visually or hearing impaired, Mothers who are not primary school graduates, Both he and his mother are not open to communication and cooperation, Neither they nor their mothers volunteered to participate in the research, Children and mothers without smart phones - HealthyVolunteers: No - Gender: All - MinimumAge: 9 Years - MaximumAge: 16 Years - StdAgeList: Child
Inorganic Pyrophosphate Homeostasis (PPi) in Pediatric Chronic Kidney Disease
Status: Not yet recruiting

The investigator aim to identify the role of inorganic pyrophosphate and other anti-calcifying molecules in vascular disease in children with chronic kidney disease, with a view to developing therapeutic approaches aimed at limiting the onset of vasculopathy.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  All groups :  Minor patients (<18 years) Patients of both sexes Informed patients and parents who have signed the informed consent form Patients affiliated to social security  Control group :  - Patients with no particular pathology undergoing surgery and receiving a preoperative check-up  CKD groups :  Patients on dialysis for more than 3 months, regardless of technique Kidney transplant patients Patients with CKD, whatever the cause  Exclusion Criteria:  Progressive cancer or kidney disease Treatments that may modify PPi concentration (e.g. bisphosphonates) - HealthyVolunteers: No - Gender: All - MinimumAge: 0 Years - MaximumAge: 18 Years - StdAgeList: Child, Adult
Evaluation of Modified Hyrax Versus Quad Helix in Treatment of Posterior Cross Bite
Status: Recruiting

This study will be performed to evaluate the treatment of posterior cross-bite with modified hyrax & Quad helix appliances and to compare which one will provide better results in relation to chewing difficulty in children with posterior cross- bite in mixed dentition

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Children with posterior cross-bite in mixed dentition stage. Children with normal and mild growth pattern. Children with completely erupted upper first molars.  Exclusion Criteria:  Children with advanced periodontal diseases. Children having general diseases, syndromes. Children with previous orthodontic. Children with severe horizontal growth patterns. - HealthyVolunteers: No - Gender: All - MinimumAge: 6 Years - MaximumAge: 18 Years - StdAgeList: Child, Adult
Outcomes and Risk Factors of CPR in PICU
Status: Not yet recruiting

To detect the frequency and the underlying causes of cardiopulmonary arrest .
To detect outcome of CPR
To identify the associated risk factors for the different outcomes after CPR among those patients

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Including Children aged 1 month to 18 years who received at least 1 minute of CPR  Exclusion Criteria:  Exclusion of 1-Children aged below1 month and older than 18 years . terminal disease patients, such as malignancy - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 1 Month - MaximumAge: 18 Years - StdAgeList: Child, Adult - StudyPopulation: Children aged from 1 month to 18 years who suffered in-PICU CA between March 2024 to February 2025 will be included. Cardiopulmonary arrest was defined as the presence of unresponsiveness, apnea, absence of signs of life, and absence of a palpable central pulse or bradycardia of <60 bpm with poor perfusion in infants, requiring external cardiac compressions and assisted ventilation - SamplingMethod: Non-Probability Sample
Exploring CBTi's Dual Effect on Sleep, Diet, & Chrononutrition
Status: Recruiting

This study aims to investigate the effects of Cognitive Behavioral Therapy for Insomnia (CBTi) on both sleep patterns and dietary habits in Lebanese adults with insomnia. Sleep patterns and dietary habits are intricately linked, with dysregulated sleep associated with poor diet quality and increased snacking. Conversely, the types of nutrients consumed can affect hormonal balance and circadian rhythm. Insomnia and obesity are interrelated public health concerns, with CBTi showing efficacy in improving sleep. This study will recruit participants with insomnia and randomly assign them to receive either CBTi or basic sleep hygiene education. Baseline assessments will include validated questionnaires about insomnia, dietary habits, and physical activity and a 7-day 24-hour diet recall sheets, as well as actigraphy for sleep parameters, and physical activity assessments. The intervention will last for four weeks, with post-intervention assessments conducted similarly to baseline.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  English literate adult men and women participants aged 18 to 65 years with a complaint of insomnia.  Exclusion Criteria:  Participants under 18 years old or above 65 years old. Participants with a known sleep disorder other than insomnia (sleep apnea, narcolepsy, or restless leg syndrome). Participants with a history of neurological disease including epilepsy/seizures and traumatic brain injury. Participants with active psychosis. Participants with hearing impairment. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult
The Effect of Subtalar Joint Pronation Amount on Lower Extremity Alignment and Performance
Status: Recruiting

The lower extremity consists of segments that can be affected by the relative position of each other. Deviation of one segment from its normal alignment in the lower extremity also affects the alignment of other segments. The hip joint can affect the frontal plane alignment from proximal to distal, while the foot and ankle complex can also affect it from distal to proximal. Increased subtalar joint pronation in the kinetic chain from distal to proximal; is associated with decreased dorsiflexion angle and increased frontal plane projection angle. It has been shown that ankle dorsiflexion limitation causes changes in the biomechanics and kinematics of landing after jumping, but no study examining the effect of foot pronation on jump tests has been found in the literature. Since the foot is located at the most distal point and acts as a support base for the kinematic chain, the smallest dynamic change in the foot affects the balance of the whole body. Due to foot pronation, changes in the sole contact surface may make it difficult for the foot to adapt to the ground, balance and postural stabilization may be adversely affected, and an increase in the workload of the muscles around the joint may be observed. In another study, it is mentioned that there is limited evidence about the effect of foot posture on postural stability. Although there are studies in the literature examining the effects of subtalar joint pronation on lower extremity alignment and postural stability, studies need to examine the effects of different subtalar joint pronation amounts on lower extremity alignment, jumping performance, and postural stability. Our study will contribute to the literature with this aspect.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  - Being between the ages of 18-40  Pain, difficulty in walking and loss of function, etc. not having complaints Foot posture index value should be between 6-12 Not having any orthopedic disease Not having visual or hearing impairment Not having been involved in any physical therapy program in the last 6 months. Not having undergone any surgical procedure on the lower extremity Not using analgesic medication within the specified treatment days throughout the research period.  Exclusion Criteria:  Having a lower extremity congenital anomaly Having a history of lower extremity surgery or planned lower extremity surgery within the next 12 months Having any signs of pain in the lower extremities Having ligament hyperlaxity Having a history of tendon or cartilage injury Having serious illnesses Predominant knee pain from other knee structures, hip or lumbar spine Having a history of using any shoe insert-orthosis-insoles or knee injection in the last 3 months Having any neurological or systemic inflammatory arthritis disorder (neurological involvement that affects movement) - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 40 Years - StdAgeList: Adult
Stellate Ganglion Block for Preserving Arteriovenous Fistula in Hemodialysis Patients Undergoing Major Lower Limb Orthopedic Surgery
Status: Recruiting

The aim of this study is to evaluate the role of stellate ganglion blockade (SGB) for preserving arteriovenous fistula in hemodialysis patients undergoing major lower limb orthopedic surgery.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age 21 to 75 years. Both sexes. American Society of Anesthesiologists (ASA) physical status III. Chronic renal failure (CRF) patients. Undergoing major lower limb orthopedic surgery.  Exclusion Criteria:  Psychiatric disorders. History of substance abuse. Ipsilateral brachial and radial artery stenosis. Allergy to local anesthetics. Cardiovascular and respiratory disorders. Coagulopathy. Use of vasoactive medications. Obesity (body mass index >30 kg/m2). Smoking. - HealthyVolunteers: No - Gender: All - MinimumAge: 21 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult
Geriatric Locomotive Syndrome and Related Factors in Older Adults
Status: Recruiting

It has been stated that the results of physical function and physical performance affecting locomotive syndrome in elderly individuals are controversial and studies are still needed. However, no studies have been found examining its relationship with the decrease in physical activity level, decline in cognitive functions, kinesiophobia (fear of movement) and fatigue seen in old age. Early detection of locomotive syndrome risk factors in elderly individuals will help prevent this condition, detect the risk of falling in elderly individuals and increase their quality of life. Based on these deficiencies, it is aimed to examine the relationship between locomotive syndrome and kinesiophobia, physical activity level, physical performance, fatigue and cognitive functions in elderly individuals.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Individuals aged 65 and over, Volunteering to participate in research No cooperation and communication problems (Mini Mental State Test score above 24)  Exclusion Criteria:  Individuals with neurological and orthopedic problems  Uncontrolled hypertension Those with cardiac disease Those with cooperation and communication problems - HealthyVolunteers: No - Gender: All - MinimumAge: 65 Years - MaximumAge: 85 Years - StdAgeList: Older Adult - StudyPopulation: At Kırıkkale University Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, all elderly individuals aged 65 and over who meet the inclusion and exclusion criteria and who volunteer to participate in the study will be collected by face-to-face interview using evaluation forms. - SamplingMethod: Non-Probability Sample
Nociception Index Level (NOL) Perioperative Monitoring During Regional Anesthesia
Status: Recruiting

This prospective observational study was conducted to assess pain using NOL index under locoregional anesthesia for orthopedic surgery of the upper limb. We included 50 consecutive adult patients scheduled for orthopedic surgery of the upper limb under locoregional anesthesia. The locoregional anesthesia was performed under ultrasound, with or without neurostimulation. Intraoperative pain is assessed using NOL index monitoring, ALGISCORE and Numerical Scale, and second point study is the midazolam and propofol requirement.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  scheduled upper limb orthopedic surgery under regional anesthesia  Exclusion Criteria:  Patient less than 18 years old emergency surgery patient refusal of regional anesthesia chronic neurocognitive disease - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: all the patients scheduled to undergo an upper limb orthopedic surgery under regional anesthesia - SamplingMethod: Non-Probability Sample