rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
Metabolomics and Bariatric Surgery in Patients With Metabolically Unhealthy Obesity
Status: Recruiting

The goal of this observational study is to investigate metabolic changes in individuals undergoing bariatric surgery, specifically focusing on those with obesity and varying metabolic health statuses. The main questions it aims to answer are:

Can metabolic markers predict the transition from metabolically unhealthy obesity to metabolically healthy obesity after bariatric surgery?
How do metabolic profiles change in individuals with metabolically healthy obesity after bariatric surgery?
What are the metabolic differences between individuals with metabolically healthy and unhealthy obesity before and after bariatric surgery?

Participants will undergo routine evaluations and blood tests before and after bariatric surgery. These tests will include assessments of metabolic health markers and sampling of blood plasma for metabolomic analysis. The study will study changes in metabolic profiles between individuals who transition to metabolically healthy obesity and those who remain metabolically unhealthy after surgery.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients undergoing bariatric surgery at the Hospital del Mar in Barcelona. Criteria for bariatric surgery are:  Ages between 18 and 60 years. Body Mass Index (BMI) equal to or greater than 40, or equal to or greater than 35 kg/m2 with at least one obesity-related comorbidity (type 2 diabetes mellitus, hypertension, dyslipidemia, obstructive sleep apnea syndrome). Previous failure with conventional treatment involving diet and exercise.  Exclusion Criteria:  History of previous bariatric surgery. Presence of severe psychiatric disorders, severe eating disorders, alcohol or drug abuse. Contraindications for major abdominal surgery, active gastric ulcer, severe liver disease.  Pregnancy or lactation. - Gender: All - MinimumAge: 18 Years - MaximumAge: 60 Years - StdAgeList: Adult - StudyPopulation: The study population will consist of patients who have undergone bariatric surgery at the Hospital del Mar in Barcelona and meet the aforementioned inclusion criteria. These patients will be consecutively selected and must agree to participate in the study. - SamplingMethod: Non-Probability Sample
COVIDVaxStories: Randomized Trial to Reduce COVID-19 Vaccine Hesitancy in Populations of Color
Status: Recruiting

Pilot randomized controlled trial testing the investigator's previously developed storytelling method to create an interactive, multi-media storytelling intervention to address community-identified reasons for vaccine hesitancy among Black and Hispanic individuals in Central Massachusetts

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  >= 18 years of age identifies as Black and/or Hispanic lives in Massachusetts vaccinated for COVID-19.  Exclusion Criteria:  Unable to provide consent in English or Spanish Has not completed the primary series of COVID-19 vaccinations (2 shots for Moderna or Pfizer, one shot for Johnson & Johnson). - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 105 Years - StdAgeList: Adult, Older Adult
Head Down Tilt 15° to Increase Collateral Flow in Acute Ischemic Stroke
Status: Not yet recruiting

The DOWN-SUITE study is multicenter, randomised, controlled, open-label clinical trial with blinded outcome assessment comparing collateral status in patients with acute ischemic stroke treated with an in-hospital application of head down tilt -10° to -15° (HDT15) versus usual positioning (0° to +30°) before endovascular mechanical thrombectomy.

This study will involve adult patients who are eligible for mechanical thrombectomy and who have acute ischemic stroke due to left or right middle cerebral artery occlusion (M1 segment).

The investigators hypothesise that HDT15, applied in acute ischemic stroke patients with a large vessel occlusion, will improve collateral circulation, prolong the survival of the ischemic penumbra and improve the clinical benefit from mechanical thrombectomy compared with standard of care (usual positioning 0° to +30°).

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Acute ischemic stroke due to left or right MCA occlusion of the M1 segment (excluding occlusion of the internal carotid artery terminus + M1) Decision to treat with mechanical thrombectomy (with or without intravenous thrombolysis) Informed consent obtained from patient or patient's next of kin, or emergency consent procedure  Exclusion Criteria:  Impaired consciousness, defined as NIHSS score of 2 or 3 of the item 1a (level of consciousness): not alert, requires repeated stimulation or unresponsive. Vomiting upon stroke onset. History of glaucoma. History or imaging findings of intracranial hypertension of any aetiology  Major breath disorders, defined as follows:  oxygen saturation ≤92% in room air at admission severe chronic obstructive pulmonary disease (COPD) treated with long-term oxygen therapy. severe heart failure with NYHA class 3 or 4 (breathlessness during ordinary physical activity or at rest). Severe obesity, defined as body mass index (BMI) > 35. Patients participating in another interventional trial that would interfere with this study. Female patients who are pregnant - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Accuracy of Continuous Glucose Monitoring in Patients With Diabetes. A Prospective Observational Study
Status: Not yet recruiting

The goal of this observational study is to investigate the accuracy of the continuous glucose monitoring (CGM) compared to standard point-of-care (POC) blood glucose measurements in patients with diabetes in patients who during their hospital admission can experience circulatory impairment.

The main questions it aims to answer are:

• Do CGM measurements have a decreased accuracy compared to standard blood glucose measurements in periods with circulatory impairment?

Participants will be asked to wear a blinded CGM device (Dexcom G7, Dexcom Inc.) during their stay in the hospital but will receive standard care of their diabetes. The CGM device will be worn for up to 10 days.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Medical history with diabetes mellitus requiring antidiabetic drugs Age ≥18 years Surgery with estimated surgery time ≥45 minutes with expected stay for at least one night in hospital postoperatively OR Admission to the ICU with Circulatory impairment defined as need of vasopressors to maintain a mean arterial pressure (MAP) ≥65 mmHg and peripheral perfusion index <1.5  Exclusion Criteria:  Local skin symptoms including infection at the posterior aspect of the upper arm that does not allow the sensor to be placed on an unaffected skin area Contraindications to skin puncture (arteriovenous fistula for dialysis, post-mastectomy lymphoedema etc) Known allergy to plaster used in the CGM device - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: To the answer of our two research questions, we include both patients with diabetes undergoing surgery, and patients with diabetes admitted to the intensive care unit with circulatory impariment, as described in the criteria above.  We aim to exclude only patients with direct contraindications to the wear of the CGM. - SamplingMethod: Probability Sample
ADAPT-AST (Adaptive Antimicrobial Susceptibility Testing)
Status: Not yet recruiting

The goal of this study is to improve the way urinary tract infections (UTIs) are tested for antibiotic resistance. The main questions it aims to answer are:

Can the investigators use a method called Bayesian causal inference to create or check clinical prediction models that help predict if certain antibiotics will work for a urinary infection, using patient information from the National Health Service (NHS)?
Can this new ADAPT-AST method, which uses data and a smarter approach, do a better job of testing for urinary infection than the old methods? Will it help doctors make quicker decisions and save resources by being more efficient?

Participants in this study will not be receiving treatments. The study will involve:

Using statistical methods to predict UTI test results based on patient data. Evaluating whether this new approach can provide doctors with more timely and useful information for treating UTIs.

Assessing whether it can help save money and resources in the lab and pharmacy.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  o The specimens for which AST predictions & recommendations will be made are urine specimens processed by LCL Microbiology laboratory taken from patients ≥ 18 years old in LUHFT and/or GP locations that grew organisms within the period of the study dataset; these are the only specimens for which AST results will be available to train and test ADAPT-AST. Predictions will be made for all urine specimen types, including mid-stream urines, catheter specimens of urine and nephrostomy urine.  Exclusion Criteria:  Urine specimens processed by LCL that did not grow organisms within the period of the study dataset Urine specimens taken from patients < 18 years old Predictions will be made for asymptomatic bacteriuria screening specimens in pregnant women who have had specimens sent from a GP, but not those which have been sent from Liverpool Womens' NHS Foundation Trust (LWfT) Predictions for non-bacterial organisms grown in urine (i.e., fungi) will not be made. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Patients with a suspected Urinary Tract Infection - SamplingMethod: Non-Probability Sample
Feasibility of Emotion Regulation Group Therapy for Adolescent Self-Harm
Status: Recruiting

Deliberate self-harm (DSH) is a prevalent behaviour among adolescents but there is no current recommendation for an efficacious treatment. Emotion regulation group therapy (ERGT) is a brief treatment for DSH with a well-documented utility and feasibility in the adult population, and an adapted version for adolescents may provide equal benefits for adolescents, provided adjustments to prevent or decrease social contagion are present.

A quantitative feasibility open trial (N=20) followed up by a qualitative interview study will examine the feasibility, acceptability and preliminary effect of ERGT for adolescents.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  13-17 years of age; having engaged in deliberate self-harm (DSH)-behaviours ≥ 5 times the last year; having engaged in ≥1 DSH episode during the past month; having ongoing psychiatric treatment in the community; having at least one caregiver or other significant adult, committed to participate in the parent program; and stability of psychotropic medications  Exclusion Criteria:  a diagnosis of psychotic, bipolar I disorder or severe social anxiety disorder (SAD); ongoing substance dependence; the presence of co-occurring psychiatric disorders that require immediate treatment; having an autism spectrum disorder together with borderline intellectual disability or having an intellectual disability; insufficient understanding of the Swedish language - HealthyVolunteers: No - Gender: All - MinimumAge: 13 Years - MaximumAge: 17 Years - StdAgeList: Child
Effects of Telerehabilitation-Based Interventions on the Musculoskeletal System in Drivers
Status: Not yet recruiting

This study is designed to examine the effect of telerehabilitation application on the musculoskeletal system of drivers.The study will include 40 voluntary participants who work as drivers on inter-district routes in Sakarya. The participants' sociodemographic information, musculoskeletal problems, and postures will be assessed. Participants will be divided into two groups: one group will receive tele-rehabilitation with posture and stabilization exercises, while the other group will serve as the control group. The exercises will be implemented for 10 weeks, followed by an 8-week tapering period, after which the groups will be crossed over. A re-evaluation will be conducted after 10 weeks, with follow-up assessments scheduled for 3 months later.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Individuals working as drivers in intercity minibuses in Sakarya. Those who have been working as drivers for at least one year. Age between 30 and 65. Male gender. Those who can use a smartphone. Those who can use at least one of the following applications: WhatsApp, Zoom, or Teams.  Exclusion Criteria:  Orthopedic surgeries undergone within the past year. Inability to obtain consent to participate in the study. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Male - GenderBased: Yes - GenderDescription: The study will be conducted only on male drivers. - MinimumAge: 30 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult
Online, Gut-directed Hypnotherapy for Patients With Irritable Bowel Syndrome (IBS)
Status: Recruiting

Adult IBS patients with symptoms refractory to standard medical treatment will receive online nurse-administered, gut-directed hypnotherapy in groups. The primary outcome measure was change in gastro-intestinal symptom severity.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  IBS diagnosis  Exclusion Criteria:  Organic GI disease - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult
Compare the Efficacy and Safety of Dec-FB4 and FB4 as Conditioning Regimen for AML-MR
Status: Not yet recruiting

A multicenter, randomized, controlled clinical study comparing the efficacy and safety of allogeneic hematopoietic stem cell transplantation with decitabine-Fludarabine- busulfan (Dec-FB4) and Fludarabine-busulfan (FB4) as pretreatment regimens for the treatment of acute myeloid leukemia in adults with MR gene abnormalities

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age 16-65 years and with an ECOG physical fitness score of 0-2 and an HCT-CI of less than 3; Diagnosis: All enrolled cases were diagnosed with acute myeloid leukemia (AML-MR) after bone marrow cytomorphology, cytochemistry, immunophenotyping, chromosomal examination, and gene mutation, and achieved hematological remission (bone marrow smear primitive cells <5%) and negative MRD before transplantation. Have a medically qualified and suitable hematopoietic stem cell donor, including HLA-allogamous sibling donors, unrelated donors (HLA high-resolution 9-10/10 compatible) or related haploidentical donors; No dysfunction of the heart, liver, lungs, kidneys, or other important organs, as defined as follows: ALT and AST ≤3 times the upper limit of normal; total bilirubin ≤2 times the upper limit of normal); BUN and Cr ≤1.25 times the upper limit of normal; electrocardiograms not suggestive of acute myocardial infarction or serious arrhythmias; cardiac echocardiography left ventricular ejection fraction ≥50%, no significant cardiac enlargement, valvular disease, or congenital heart disease; pulmonary function examination FEV1, FVC, DLCO ≥ 60% of the predicted value. The patient and his/her legal representative have the desire and requirement to undergo hematopoietic stem cell transplantation and sign an informed consent, willingness and compliance with the treatment plan, follow-up schedule, laboratory tests, etc.  Exclusion Criteria:  AML in unremitting stage; or BM in remission but with concurrent CNS leukemia or presence of extramedullary lesions; Active hepatitis B (HBV-DNA ≥1×10^3 copies/ml); HIV-infected patients; Active infections requiring intravenous antibiotic therapy; There is severe impairment of vital organ function: respiratory failure, heart failure, decompensated hepatic insufficiency, renal insufficiency, etc; Patients who use drugs or chronic alcohol abuse to the extent that it interferes with the evaluation of test results; Mentally challenged/unable to obtain informed consent; Those judged by the investigator to be unsuitable for participation in this trial. - HealthyVolunteers: No - Gender: All - MinimumAge: 16 Years - MaximumAge: 65 Years - StdAgeList: Child, Adult, Older Adult
The Validity and Reliability Study of Turkish Version of the Sense of Competence in Dementia Care Staff (SCIDS) Scale
Status: Not yet recruiting

The purpose of the study is to adapt the SCIDS into the Turkish version and validate it in the social and cultural context of Turkey to assess staff competency in dementia care in the long-term care setting.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Working as a dementia care staff for at least 1 year  Exclusion Criteria:  Not volunteering - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Working as a dementia care staff in Acıbadem Health Group - SamplingMethod: Non-Probability Sample
Turkish Adaptation, Validity and Reliability of the Approaches and Study Skills Inventory in Physiotherapy Students
Status: Not yet recruiting

The quality and quantity of learning are determined by the learning approach adopted by the student. When learning and studying approaches are mentioned, individual differences between learners' learning intentions during a learning situation or while studying and what types of strategies are used to achieve these intentions come to mind. These learning approaches are thought to determine the quality of learning outcomes. Many measurement tools have been developed to quantitatively measure learning and studying approaches. These developed tools are mostly applied at the higher education level. Among the purposes of using measurement tools; These include identifying low-performing students through screening, evaluating and identifying areas of difficulty that require prediction or improvement plans, evaluating before and after academic improvement programs, and raising awareness and advising students on their academic strengths and weaknesses.

When multidimensional measurement tools that evaluate students' study approaches and skills are examined, it is seen that the use of the Approaches and Study Skills Inventory for Students (ASSIST) tool has become widespread in recent years. This vehicle; It has been reported that it measures learning strategies and skills for different students and is sensitive enough to distinguish between learning types.

The Portuguese, Norwegian and Danish versions of the survey, which was developed in English and intended to be translated into Turkish as the Study Skills and Approaches Scale, have also been translated, its psychometric properties have been demonstrated and it has been observed that it is becoming widespread in the literature.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Being between the ages of 18-30 Being a student at the Department of Physiotherapy and Rehabilitation of the Faculty of Health Sciences  Exclusion Criteria:  People with vision problems that would prevent participation in the study Participants who have not filled out the forms completely will be excluded from the research. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 30 Years - StdAgeList: Adult - StudyPopulation: The population of the research consists of undergraduate students of the physiotherapy and rehabilitation department. - SamplingMethod: Non-Probability Sample
Early Oral Hydration After Thoracoscopic Surgery
Status: Not yet recruiting

The goal of this clinical trial is to learn about the safety and feasibility of early oral hydration in patients receiving video-assisted thoracoscopic surgery after general anesthesia. The main questions aims to answer:

the safety and feasibility of oral hydration supplementation in the recovery room following general anesthesia.
the degree of improvement in sore throat and dry mouth after oral hydration.
the side effects and risks of oral hydration supplementation, such as the incidence of postoperative nausea and vomiting.
the impact of oral hydration supplementation in the recovery room following general anesthesia on hemodynamics.
patient satisfaction with oral hydration supplementation in the recovery room following general anesthesia.

Participants will receive a series of oral hydration from swab moistening, and ice cube hydration to water hydration in the recovery room. Researchers will compare with the standard, no-hydration group to see if it is safe and feasible to hydrate patients in the recovery room.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Males and females aged 18 to 70. Anesthesia physical status classification III or below Body Mass Index 30 or below Elective video-assisted thoracoscopic surgery  Exclusion Criteria:  Pre-operative throat pain Impaired mental status Tendency to choke (inc. dysphagia, stroke hx.) Nil Per Os (NPO) less than 8 hours Pregnancy Nausea and vomiting in Operating room or Post-anesthesia care unit - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 20 Years - MaximumAge: 70 Years - StdAgeList: Adult, Older Adult
Effect of Aquatic High Intensity Resistive Training on Patients With Chronic Heart Failure
Status: Recruiting

PURPOSE:

to evaluate effect of aquatic high intensity resistive training on cardiac function and exercise capacity in patients with chronic heart failure.

BACKGROUND:

Heart failure (HF) is a rapidly growing public health issue with an estimated prevalence of >37.7 million individuals globally. HF is a shared chronic phase of cardiac functional impairment secondary to many etiologies, and patients with HF experience numerous symptoms that affect their quality of life, including dyspnea, fatigue, poor exercise tolerance, and fluid retention.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age ranges from 45 to 60 years old. Have chronic heart failure (NYHA class I to III).  Left ventricular ejection fraction (LVEF) > 50% clinically stable with optimal pharmacological therapy in greater than three months All patients didn't participate in any rehabilitation programs prior to the study.  Exclusion Criteria:  Signs of acute heart failure, unstable angina, or severe arrhythmia three months prior to enrolment in the study.  Pacemakers. recently diagnosed acute coronary syndrome or a recent coronary intervention or both renal insufficiency (estimated glomerular filtration rate < 30 mL/min) liver abnormalities uncontrolled hypertension moderate-to-severe valvular disease uncompensated heart failure patients Chronic lung disease. Other disorders counteracting exercise conditions that limit lower limb mobility (for example, burns, fractures) - HealthyVolunteers: No - Gender: All - MinimumAge: 45 Years - MaximumAge: 60 Years - StdAgeList: Adult