rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
Physical Activity Monitoring in Myasthenia Gravis
Status: Recruiting

The goal of this observational study is to evaluate the feasibility of using wearable sensor and digital technologies to measure motor and speech function in adults with autoimmune Myasthenia Gravis (MG).

The main question[s] it aims to answer are:

To measure the correlation of sensor-based measures of motor function with existing outcome measures including the MG-ADL, MGQOL15r, QMG, MGComposite, and Neuro-QOL Fatigue scales.
To develop and validate tablet-based digital assessments of speech and facial expression and to compare with existing outcome measures.

Participants will wear a pendant sensor for 7 days and then participate in tablet-based and in-person myasthenia-specific physical examinations. This will be performed in concert with routine care in the Massachusetts General Hospital MG clinic.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Autoimmune generalized MG with or without history of thymoma, MGFA severity Class Ila/b, Illa/b or IVa Acetylcholine receptor antibody (AChR Ab) or muscle specific kinase receptor antibody (MuSK Ab) positive. Able to provide informed consent (physically/cognitively) and adhere with the protocol based on investigator's judgement Ambulatory, defined as able to independently walk a distance of 10 meters, with or without assistive device Male or female, aged 18-80 years Speaks English as primary language  Exclusion Criteria:  Inability to engage in activities that are essential for independent living, such as dressing, bathing, toileting, eating independently. Neurological or orthopedic problems independent of myasthenia which significantly affects gait in the investigator's judgement Any significant medical, laboratory, or psychiatric condition that, in the judgment of the investigators, would potentially interfere with the ability to participate in the study Residence in long-term care centers or institutions, nursing facilities, skilled nursing facilities, or recipients of hospice care, or incarceration MGFA severity class IVb (severe bulbar weakness) or V (MG crisis) Pregnant or breastfeeding women Concurrent participation in an interventional clinical trial (observational studies, biomarker studies and registries are acceptable) - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Adult patients with generalized autoimmune myasthenia gravis who are existing patients in the Mass General Hospital Neuromuscular Clinic - SamplingMethod: Non-Probability Sample
Effect of Combined Music and Taekwondo Training for Children With Autism Spectrum Disorder
Status: Not yet recruiting

The goal of this randomized controlled trial is to evaluate the effect of combined music and taekwondo training on the mental and physical condition of children with autism spectrum disorder. Participants will be asked to do combined music and taekwondo training or taekwondo training alone to evaluate if the combined training is better than the taekwondo training alone on mental and physical performance for children with autism spectrum disorder.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Chinese children aged 7 to 9 years who have been clinically diagnosed as ASD by developmental paediatricians or clinical psychologists based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria for ASD.  Exclusion Criteria:  children who have experience in Taekwondo training; children who have received music therapy within the previous 12 months; those who have severe sensory disorders (blindness or deafness); those who have underlying congenital abnormalities or other diseases that limit their ability to engage in physical activities. - HealthyVolunteers: No - Gender: All - MinimumAge: 7 Years - MaximumAge: 9 Years - StdAgeList: Child
Study of CM310 Injection in Adolescent Subjects With Atopic Dermatis
Status: Not yet recruiting

This is a multi-center, randomized, double blind, placebo-controlled phase 3 study to evaluate the efficacy, safety, PK, PD and immunogenicity of CM310 in children patients with moderate-to-severe atopic dermatitis.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Have the ability to understand the study and voluntarily sign a written informed consent form (ICF). With Atopic Dermatitis.  Exclusion Criteria:  Not enough washing-out period for previous therapies. Any major surgery planned during the research period. With intestinal parasitic infection within the 6 months before screening. With any circumstance that is not suitable to participate in this study. Major surgeries are planned during the study period. - HealthyVolunteers: No - Gender: All - MinimumAge: 12 Years - MaximumAge: 18 Years - StdAgeList: Child, Adult
A Study to Investigate the Pharmacokinetic/Pharmacodynamic Characteristics of IBI128(A New Xanthine Oxidase Inhibitor)
Status: Not yet recruiting

A Phase I study to evaluate the pharmacokinetic/pharmacodynamic characteristics,safety and tolerability of IBI128 after multidosing in Chinese health subjects.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Healthy male subjects between the ages of 18 and 50 years at screening; Subjects with a Body Mass Index (BMI) between 18.0 (inclusive) and 28.0 kg/m2 (inclusive); and a total body weight ≥55kg (male） and 45kg (female) Participants who are overtly healthy as determined by medical evaluation including medical history, laboratory tests, vital signs and standard 12 lead ECGs. Subject is willing to participate and to Sign written informed consent form.  Exclusion Criteria:  Subjects with a history of hypersensitivities to investigational products, including drug allergies (caused by aspirin, antibiotics, etc.), or a history of clinically significant hypersensitivities Subjects with evidence or a history of gastrointestinal disease (Crohn's disease, ulcer, acute or chronic pancreatitis, etc.) or surgery (except simple appendectomy or repair of hernia) that may influence drug absorption Subjects with evidence or a history of clinically significant hepatic (including carrier of viral hepatitis), renal, neurologic, immunologic, pulmonary, endocrine, hematological, neoplastic, cardiovascular or psychiatric (mood disorder, obsessive-compulsive disorder, etc.) diseases. Subjects with a history or current have mental disease. Subjects who have taken any medicine that may affect outcomes within 30 days before the first administration of the investigational product. Subject who have taken IBI128 in other studies. Subjects who have a history of acute arthiritis. Pregnant women or breast-feeding women or men and women who has possibility of pregnancy. Subjects judged not eligible for the study after reviewing the clinical laboratory results or other reasons by the investigator - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 50 Years - StdAgeList: Adult
The Effect of Two Non-pharmacological Methods on Pain and Anxiety Experienced During Intrauterine Device Application.
Status: Recruiting

The purpose of this study is to determine the effect of emotional freedom technique and music, which are effective in relieving pain and anxiety, on the pain and anxiety that occur during intrauterine device application.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Voluntarily agreeing to participate in the research Being between the ages of 18-49  Exclusion Criteria:  Having a verbal communication problem Being medically diagnosed with a psychiatric disorder Presence of wounds, scars and infections in the areas touched in the emotional freedom technique Having a hearing problem Having had an intrauterine device (IUD) inserted before Being exposed to domestic violence Being diagnosed with any medical condition (hypertension, diabetes, etc.) Having used analgesics seven hours before the procedure Having a gynecological examination just before IUD application - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - GenderBased: Yes - MinimumAge: 18 Years - MaximumAge: 49 Years - StdAgeList: Adult
Preventing Exercise Resistance With Sedentary Interruptions
Status: Recruiting

The goal of this randomised cross-over trial is to learn about the interaction between sedentary behaviour throughout the day and the metabolic effect of an exercise bout on that same day in office workers with an increased risk for chronic disease.

The main question this study aims to answer is if the lipid-lowering effects of an exercise bout can be more pronounced by implementing alternations between a seated and a standing working position throughout the day.

Participants will be asked to:

Complete three intervention periods for a duration of 2 days at their workplace,
Attend a supervised training session (60min) at the research facility at the end of each intervention period,
Attend three assessment days at the research facility where postprandial metabolism will be evaluated after a standardised meal test.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  between 30 and 65 years old, primarily work in an office environment for at least 0.75 full time equivalents, sedentary (on average >9h of sedentary time per day, assessed objectively), at an increased risk for disturbances in lipid profile (assessed with fingerstick (Analox®) total cholesterol >200 mg/dL or fingerstick triglycerides >150 mg/dL), written informed consent to participate in the study.  Exclusion Criteria:  medical conditions precluding physical activity (PA) participation, abusive alcohol intake (>20 units/week), pregnant or intention to become pregnant, change in dietary habits or weight loss (>2kg) in the last month before the study, a diagnosis of cardiometabolic diseases such as diabetes mellitus or cardiovascular diseases. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 30 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult
Effects Of Dynamic Stabilizatıon Exercises And HVLA Manipulatıon in Low Back Paın
Status: Not yet recruiting

Our aim is to contribute to the literature by comparatively examining the effects of DNS exercises and chiropractic HVLA manipulation on pain, pain-related functional impairment (disability), physical competence level, dynamic fitness level of core muscles and postural deviations in patients with chronic nonspecific low back pain.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  7 points in Oswetry Disability Index (ODI) Participants should be between the ages of 20 and 45 Normal radicular tests Being diagnosed with low back pain 6 months Not having perception problems and being able to cooperate well Signing the voluntary consent form  Exclusion Criteria:  Pregnancy History of previous spinal canal surgery Presence of neurological deficits Presence of cancer Having an inflammatory or rheumatologic disease Spinal deformities (due to infection or trauma, compression fracture) - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 20 Years - MaximumAge: 45 Years - StdAgeList: Adult
The Mom and Infant Outcomes (MOMI) Study
Status: Not yet recruiting

The investigator's long-term goal is to mitigate pregnancy-related mortality (PRM) risk by systematically delivering integrated clinical and supportive care that is effective, equitable, and scalable. The investigator's central hypothesis is that the Multi-modal Maternal Infant Perinatal Outpatient Delivery System (MOMI PODS) will mitigate postpartum (PP) risk and reduce disparities in PP risk by improving biopsychosocial profiles and facilitating access to evidence-based clinical and supportive care. To test this hypothesis, the investigators will conduct a hybrid type 1 randomized controlled trial (RCT) of MOMI PODS versus enhanced usual care (EUC, which we will term MOMI CARE) among a total sample of 384 mother-infant dyads (192/group) following pregnancy affected by a cardiometabolic and/or mental health condition. The investigators will enroll participants on PP day 1 and collect data at baseline and 6 months and 1 year PP. The investigators will collect implementation and service data across sites.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  index pregnancy affected by one or more of the following that is reflected in the medical record - chronic hypertension (with or without super-imposed preeclampsia); gestational hypertension; preeclampsia; eclampsia; hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome; type 1 diabetes mellitus; type 2 diabetes mellitus; gestational diabetes mellitus (GDM); a pre-existing or newly diagnosed depressive disorder (e.g., major depressive disorder, persistent depressive disorder) or anxiety disorder (e.g., generalized anxiety disorder, panic disorder); or undiagnosed depression or anxiety identified by prenatal screening [i.e., PHQ-9 score of >10, GAD-7 score of >10, Edinburgh Postnatal Depression Scale (EPDS) score of >12, or Center for Epidemiological Studies Depression Inventory (CES-D) score of >16).  Exclusion Criteria:  presence of a pre-existing, community driven MOMI PODS referral that has already been scheduled; maternal history of syncope during venipuncture; a seizure disorder; determination of maternal diminished capacity without a legally authorized representative present at enrollment; maternal age <18 without a parent or legal guardian present at enrollment. - HealthyVolunteers: No - Gender: Female - StdAgeList: Child, Adult, Older Adult
the Pericapsular Nerve Group (PENG) and Suprainguinal Fascia Iliaca Blocks (SIFIB) in Elderly Patients
Status: Recruiting

This clinical trial aims to compare the effect of the pericapsular nerve group (PENG) and suprainguinal fascia iliaca blocks (SIFIB) on pain management in elderly patients with subtrochanteric femur fractures.

The participants will be patients determined to have proximal femoral nailing. According to randomisation, each participant will receive either PENG or SIFIB postoperatively after spinal anaesthesia. The investigator will measure postoperative pain scores, total amount of analgesic consumption and motor ability postoperatively.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients over 65 Patients scheduled for proximal femoral nailing Patients with American Society of Anesthesiologists (ASA) Physical Status classification of I to IV.  Exclusion Criteria:  refusal to participate a history of neurological deficits or neuropathy infection at the site of block application coagulopathy allergy to local anaesthetics patients with severe cardiopulmonary insufficiency or renal impairment mental illness. prolonged surgery due to orthopaedic complications of more than 3 hours, necessitating conversion of spinal anaesthesia to general anaesthesia. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 100 Years - StdAgeList: Adult, Older Adult
Effect of Silymarin Against Methotrexate-induced Liver Injury in Rheumatic Diseases
Status: Recruiting

To study the effect of silymarin against methotrexate-induced liver injury in rheumatic diseases including rheumatoid arthritis, psoriatric arthritis and psoriasis

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Aged > 20 years  Diagnosis at least one of the following  Rheumatoid arthritis according to American College of Rheumatology/ The European Alliance of Associations for Rheumatology 2010(ACR/EULAR2010) with at least one joint swelling or tenderness or Psoriatric arthritis according to CASPAR classification criteria with at least one joint swelling or tenderness, or at least one site dactylitis or enthesitis or Psoriasis by dermatologist with active skin lesion No previous treatment with methotrexate or treatment with methotrexate within 30 day before randomization No previous treatment with other conventional synthetic DMARDs other than methotrexate such as sulfasalazine, hydroxycholoquine, leflunomide No previous treatment with biologic DMARDs such as anti-TNF Can follow the treatment protocal  Exclusion Criteria:  Pregnancy or planning for pregnancy Breastfeeding women Ongoing treatment with active malignancy GFR < 30 ml/min/1.73m2 Previous documented of HIV infection Chronic alcohol drinking ≥ 3 times/wk or drug abuse within 6 months prior to randomization Positive of HbsAg, anti HCV Previous documented of preexisting liver disease such as alcoholic liver disease, liver cirrhosis, autoimmune hepatitis AST or ALT > ULN ( 0-50 U/L ) WBC < 3,000/ul or platelet < 100,000 /ul, ANC < 1,500/ul ILD diagnosed by rheumatologist and pulmonologist from chest X ray and HRCT History documented silymarin hypersensitivity or severe adverse effects diagnosed by physician or pharmacist from PMK hospital or from history drug allergy or symptoms such as rash, chest tightness, dyspnea, diarrhea and hypotension Cannot follow up on treatment protocal - HealthyVolunteers: No - Gender: All - MinimumAge: 20 Years - StdAgeList: Adult, Older Adult
A Trial Investigating Lu AF28996 in Healthy Adult Participants
Status: Recruiting

The purpose of this study is to investigate repeated doses of Lu AF28996 in healthy participants and co-administered with two other compounds, and in a separate cohort following co-administration with antibiotics, to see how well the doses are tolerated and what the body does to the drug after administering it.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  The participant has a body mass index (BMI) ≥18.5 and ≤30 kilograms per meter squared (kg/m^2) at the Screening Visit and at the Safety Baseline Visit. The participant has a resting supine pulse ≥50 and ≤100 beats per minute (bpm) at the Screening Visit and at the Safety Baseline Visit. The participant has a resting supine systolic blood pressure ≥90 and ≤140 millimeters of mercury (mmHg) and a resting supine diastolic blood pressure ≥50 and ≤90 mmHg at the Screening Visit and at the Safety Baseline Visit. The participant has a normal circadian rhythm, defined as a person who usually wakes between 6:00 and 9:00 a.m. and goes to sleep between 9:00 p.m. and midnight.  Exclusion Criteria:  The participant is a member of the site staff or of their immediate families or is a subordinate (or immediate family member of a subordinate) to any of the site staff. Part B only, the participant is a woman of childbearing potential AND is using oral hormonal contraceptives. The participant has previously been enrolled in this trial. The participant has previously been dosed with Lu AF28996.  Note: Other inclusion and exclusion criteria may apply. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 55 Years - StdAgeList: Adult
The Effects of Progressive Clinical Pilates Exercises Applied as 2 Different Ways in Fibromyalgia
Status: Not yet recruiting

The aim of this study is to compare the effects of progressive clinical Pilates exercises applied as group under the supervision of a physiotherapist and home exercise programs on pain level, physical condition, functional status, psychosocial status and quality of life in individuals with fibromyalgia between the ages of 20-50.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Volunteer individuals between the ages of 20-50 Diagnosed with fibromyalgia according to the American College of Rheumatology criteria Pain level 3 and above according to visual analogue scale. Individuals who are sedentary (who have not engaged in physical activity at least 3 days a week in the last 3 months) will be included in the study.  Exclusion Criteria:  Having additional rheumatic disease Using NSAIDs and antidepressant drugs Individuals with orthopedic, neurological and cardiopulmonary diseases that prevent them from exercising Pregnant women Malignancy Individuals with uncontrolled systemic diseases (diabetes, systemic arterial hypertension, thyroid dysfunction, neurological, cardiorespiratory, musculoskeletal problems, etc.) - HealthyVolunteers: No - Gender: All - MinimumAge: 20 Years - MaximumAge: 50 Years - StdAgeList: Adult
Urban Care Farming on Living Well and Productive Engagement of Older Adults
Status: Recruiting

The goal of the randomized controlled trials is to learn about the effects of urban farming interventions on older adults' physical, mental, and social well-being of older adults aged 50 and above. The main questions the study aims to answer are Q1. Would participants who have undergone the urban care farming intervention have lower stress levels compared to those who did not undergo the intervention? Q2. Would the quality of life and biopsychosocial factors of older adults who participate in the urban farming interventions be better before the intervention and compared to those who did not participate? Q3. Would running intervention programs as such demonstrate cost-effectiveness? Participants will be enrolled in 24 weekly lessons providing hands-on urban farming techniques, including physical activity, planting, and social interactions. Researchers will compare older participants with similar demographic profile to determine if the biological, psychological, and social factors are better for the intervention group.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Aged between 50 and 80 Reside in Singapore Willing to take part in the intervention Agree for their data to be used for research purposes Ambulant and able to carry out some tasks independently  Exclusion Criteria:  Not willing to participate in the data collection (participants can opt not to answer some questions in the questionnaire but have to consent to the other data collection methods, e.g., Blood taking/test) Refusal to give informed consent Unable to give consent independently Have a disability of the upper or lower body that limits their mobility Have medical conditions which in the opinion of the research/investigative team that would compromise (or interfere with) their ability to participate in the study Had a recent severe medical episode (e.g., heart attack) - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 50 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult
Investigation of the Effect of Superimposed Neuromuscular Electrical Stimulation in Patients With Knee Osteoarthritis.
Status: Recruiting

The aim of the study is to investigate the effects of superimposed neuromuscular electrical stimulation with active contraction on physical function, muscle and joint structure, functionality, and quality of life in patients with knee osteoarthritis.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Having grade 2-3 knee osteoarthritis according to Kellgren and Lawrence Classification, Being between the ages of 40-65, , Being literate Volunteer  Exclusion Criteria:  Having Grade 2 or higher osteoarthritis in the hip, ankle, or foot joint Presence of a history of knee-related surgery (arthroplasty, meniscectomy, etc.) Having a deformity in the waist, leg, hip, knee, or ankle Having any inflammatory rheumatic, neurological, vestibular, cardiopulmonary disease Having active knee joint synovitis BMI>40 Having a condition that is contraindicate for electrotherapy (malignancy, pacemaker, epilepsy, deep vein thrombosis, loss of protective sensation, etc.) Having received physiotherapy in the last 3 months Being diagnosed with a psychiatric disease Having a cooperation problem that makes it difficult to comply with evaluation and treatment - HealthyVolunteers: No - Gender: All - MinimumAge: 40 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult