A Study to Investigate the Effect of Urine Acid-base Disequilibrium on the Pharmacokinetics of Captopril
Status: Recruiting

The aim of this study is to evaluate the effect of urine acid-base disequilibrium on the pharmacokinetics of captopril in healthy male volunteers.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Healthy male volunteer aged 19 to 50 years at screening  Body weight between 50.0 kg and 90.0 kg and body mass index (BMI) between 18.5 kg/m2 and 29.9 kg/m2 at screening  Body Mass Index (kg/m2) = Weight (kg)/{Height (m)}2 Participants who voluntarily decided to participate and agreed in writing to comply with study instructions after receiving sufficient explanation and complete understanding of the study Participants who are suitable as test subjects for this test as determined by the investigator through physical examination, clinical laboratory tests, and interviews, etc.  Exclusion Criteria:  Participants who have or have a history of clinically significant hepatobiliary system (severe liver failure, viral hepatitis, etc.), kidney (severe renal impairment, etc.), nervous system, immune system, respiratory system, digestive system, endocrine system, blood/tumor, cardiovascular system (heart failure, Torsades de pointes, etc.), urinary system, mental system (mood disorder, obsessive-compulsive disorder, etc.), and sexual dysfunction, etc. Evidence or past history of gastrointestinal disease (Crohn's disease, gastrointestinal ulcer, gastritis, gastroesophageal reflux disease, etc.) or past history of gastrointestinal surgery (except for simple appendectomy and hernia repair) that might affect the safety and PK assessment of the investigational product. Hypersensitivity to drugs including captopril, sodium bicarbonate, and torsemide or other drugs (aspirin, antibiotics, etc.) or history of clinically significant hypersensitivity reactions Participants with genetic problems such as lactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption Positive serum test (HBs antigen, HCV antibody, HIV antigen-antibody, and RPR) at screening Past history of alcohol and drug abuse or a positive urine test for drugs with abuse potential at screening  Any abnormalities in vital signs after 3 minutes rest at screening  Systolic blood pressure < 90 mmHg or > 150 mmHg, Diastolic blood pressure < 60 mmHg or > 100 mHg QT/QTcF > 450 msec or any abnormalities on electrocardiogram (ECG) at screening  Any abnormalities in blood tests at screening  AST (SGOT), ALT (SGPT) > 60 IU/L, creatinine clearance (CKD-EPI equation) < 80 mL/min Past or planned treatment with any prescription drugs or herbal medicine within 2 weeks, or any over the counter drugs, health functional foods, or vitamin supplements within 1 week, prior to the first scheduled dose (individual who is eligible based on other criteria may participate in the study at the discretion of the investigator). Participants who have taken drugs that induce drug-metabolizing enzymes such as barbiturates or inhibit drug metabolism such as clarithromycin within 1 month prior to the first scheduled dose Treatment with any investigational product in another clinical trial within 6 months prior to the first scheduled dose - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Male - MinimumAge: 19 Years - MaximumAge: 50 Years - StdAgeList: Adult