rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
Food Intake, Endocrine Factors and Brown Fat
Status: Not yet recruiting

This study will investigate how the acute intake of foods with high and low hedonic reward differentially affects brown adipose tissue and the interplay between gut peptides, brown fat, and the brain (gut-BAT-brain axis).

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  • Males and females  Between 18 and 45 years old. For the lean group: BMI<25.0 kg/m2 For the group with overweight/obesity: BMI>27.5 kg/m2 and a waist circumference of over 94 cm (men) or 80 cm (women).  Exclusion Criteria:  • Inability to have PET/CT (claustrophobia, weight > 150 kg);  Pregnancy and pregnancy-related conditions (postpartum/lactation during the last 12 months, or planning to become pregnant soon); Major alterations in the menstrual cycle (e.g., amenorrhea); Use of nicotine-based products; Hypo- or hyper- thyroidism (medical history, TSH, T3 or T4 levels out of the normal range); Diabetes mellitus (fasting Hb1Ac >6.5% or fasting glycaemia>125 mg/dL) or abnormal oral glucose tolerance test (2h OGTT > 7.8 mmol/L); Hypertension (blood pressure > 160/100 mmHg) or abnormal cardiovascular status (arrhythmia and/or long QTc in ECG, abnormal cardiac murmur, previous history of cardiovascular disease); Abnormal coagulopathy (e.g., clotting abnormality); Malignancies, immunological, autoimmune and primary/secondary immunodeficiency disorders (including or not any active treatment). Virus or bacterial infection (both asymptomatic and symptomatic picture) within the 30 days prior to the study start; Episode of fever or major surgery, burns and traumas within the month prior to the study start Chronic infections requiring chronic antibiotic or anti-viral treatment Whole blood donation in the last 3 months (>400 mL of blood) or plans for blood donation during the entire protocol period Weight change (intentional or not) over the last 6-months > than 5% of body weight, or plan to lose weight during the study, Use of any medication that, in the opinion of local clinician/researcher, would negatively affect or mitigate full participation and completion, or could influence the study results. This especially applies to the use of β or α adrenergic receptors agonists/antagonists (e.g., β-blockers). In addition, participants in use of medication for glucose control or weight loss such as GLP-1 analogs will not be included. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 45 Years - StdAgeList: Adult
Coagulation Activation in Patients With Pemphigus
Status: Not yet recruiting

Aim of work:

To evaluate the plasma markers of coagulation activation: prothrombin F1+2 and d-dimer levels in pemphigus patients with active disease and compare them with age and sex-matched controls.
To evaluate the correlation of these markers with disease severity score by using Pemphigus Disease Area Index (PDAI) and with disease activity by measurement of anti-desmoglein 1 and 3 antibody titers.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  pemphigus vulgaris patients at active stage of the disease. patients between the ages of 18 and 60.  Exclusion Criteria:  Patients with other autoimmune bullous diseases. Patients with other skin diseases. Patients with chronic liver, renal or haematological diseases. Patients with malignant tumors. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 60 Years - StdAgeList: Adult - StudyPopulation: Patients with active pemphigus who are either in a relapse for less than a week or are newly diagnosed cases will be included. The active stage of PV is defined as the de novo development of blisters on a healthy (unaffected or healed) site of either the skin or the mucous membrane.  Clinical assessment, histopathological analysis (acantholysis and intraepidermal splitting) will be used to confirm the diagnosis of each patient.  Control group: Healthy age and sex-matched subjects, who are free of chronic systemic diseases or dermatological conditions, will be enrolled as control. - SamplingMethod: Non-Probability Sample
Study Evaluating SC262 in Subjects With r/r B-cell Malignancies (VIVID)
Status: Not yet recruiting

SC262-101 is a Phase 1 study to evaluate SC262 safety and tolerability, anti-tumor activity, cellular kinetics, immunogenicity, and exploratory biomarkers.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Male or Female Subject aged 18-80 years at the time of signing the informed consent  Histologic diagnosis of NHL (based on World Health Organization 2016 criteria) including:  LBCL, including Diffuse Large B Cell Lymphoma (DLBCL) not otherwise specified (NOS) (including DLBCL arising from indolent lymphoma), Primary Mediastinal Large B-Cell Lymphoma (PMBCL), High-Grade B-Cell Lymphoma (HGBCL), and Follicular Lymphoma (FL) Grade 3B FL Marginal Zone Lymphomas (MZL) Mantle Cell Lymphoma (MCL) Relapsed or refractory disease after no more than 1 prior CD19-directed CAR T cell therapy Eastern Cooperative Oncology Group (ECOG) performance status of 0-1 At least 1 measurable (PET-positive) lesion per Lugano classification Life expectancy ≥12 Weeks  Exclusion Criteria:  Prior CD22-directed therapy including CD22-directed CAR T cell therapy or other CD22 -directed antibody or cell therapy (e.g., Natural Killer (NK) cell) History of central nervous system (CNS) involvement of lymphoma within 1 year prior to enrollment. Autologous hematopoietic stem cell transplantation (HSCT) within 3 months before treatment with Lymphodepleting (LD) chemotherapy (or allogeneic HSCT at any time) Active autoimmune disease or any other diseases requiring immunosuppressive therapy or corticosteroid therapy (defined as >10 mg/day prednisone or equivalent) History or presence of CNS disorder, such as seizure disorder, cerebrovascular ischemia/hemorrhage, dementia, cerebellar disease, or any autoimmune disease with CNS involvement, within 12 months of enrollment. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult
Comparing the Dose-response Profiles of Uterotonics After Initial Carbetocin Administration - an Ex-vivo Study in Desensitized Human Myometrium
Status: Recruiting

This study will investigate the effects of drugs called "uterotonics" that help with the contraction of the uterus after a baby is born. This uterine contraction is very important to stop the bleeding after delivery. An uncontracted uterine state is called "uterine atony", which can lead to an excessive amount of post-delivery bleeding. Carbetocin is an uterotonic drug that works well to prevent post-delivery bleeding. In some cases, carbetocin is not enough to contract the uterus, and ongoing bleeding continues. When that happens, there are other uterotonic medications that can be used. In this study, we aim to find which uterotonic drug, amongst those available (oxytocin, carbetocin, ergometrine or carboprost), is more effective to lower the risk of post-delivery bleeding once carbetocin has already been administered.

This study will be done by using a very small sample of uterine tissue, taken from the incision site, following delivery by cesarean section. The sample is taken to the laboratory and will be exposed to carbetocin followed by other uterotonic drugs. The information obtained from this study will help modify the treatment for uterine atony and post-delivery bleeding to lower the risk further.

Eligibility:
- EligibilityCriteria: Inclusion criteria  Patients who give written consent to participate in this study Patients with gestational age 37-41 weeks Non-laboring patients, not exposed to exogenous oxytocin Patients requiring elective primary or first repeat CD Patients undergoing CD under spinal anesthesia  Exclusion criteria  Patient refusal Patients who require general anesthesia Patients in labour and those receiving oxytocin for induction of labour Emergency CD placenta accreta spectrum disorder Patients who have had previous uterine surgery or >1 previous CD Patients with any condition predisposing to uterine atony and PPH (BMI > 40 kg/m2, Patients on medications that could affect myometrial contractility, such as insulin, nifedipine, labetalol or magnesium sulphate. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - MinimumAge: 18 Years - MaximumAge: 45 Years - StdAgeList: Adult
The Effects of Music on Neck Pain
Status: Recruiting

The effects of passive music listening on pain, anxiety and quality of life in patients with chronic neck pain in addition to physical therapy will be examined.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  patients with neck pain for more than 3 months with pain severity of 5 or greater according to the visual analogue scale (VAS)  Exclusion Criteria:  individuals who regularly take painkillers or anti-depressant and cortisone; and individuals having severe chronic illness and spine surgery were excluded from the study - HealthyVolunteers: No - Gender: All - MinimumAge: 30 Years - MaximumAge: 50 Years - StdAgeList: Adult
The Effect of the Association EGCG, Folic Acid and Vitamin B12 in Preventing the Persistence of HPV Infection.
Status: Not yet recruiting

The purpose of the study is to test the effect of the administration of a dietary supplement consisting of epigallocatechin gallate (EGCG), vitamin B12 and folic acid in the treatment of infections with papilloma virus of the cervix.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  HR-HPV DNA test positivity  Exclusion Criteria:  No HSIL - HealthyVolunteers: No - Gender: Female - MinimumAge: 25 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult
Impact of Workload and Fatigue on Sleep in OR Nurses
Status: Not yet recruiting

This study aims to explore the impact of individual workload and fatigue levels on the sleep quality of operating room (OR) nurses, highlighting a critical aspect of healthcare professionals' well-being that directly affects patient safety and care quality. Operating room nurses face unique challenges due to the high-stress, fast-paced environment of surgical settings, which can lead to increased stress levels, emotional challenges, and a higher incidence of fatigue compared to other nursing specialties. Factors contributing to this fatigue include the demanding nature of surgical procedures, the need for constant vigilance, and the irregular hours associated with shift work, all of which can impair sleep quality.

The literature review suggests that while the relationship between workload, fatigue, and sleep quality has been extensively studied in general nursing populations, there is a lack of specific focus on operating room nurses. These professionals work under distinct conditions that may exacerbate the effects of workload and fatigue on sleep quality, yet comprehensive studies targeting this group are limited. Understanding the nuances of how workload and fatigue specifically impact the sleep quality of OR nurses is crucial for developing targeted interventions aimed at improving their health and job performance, thereby enhancing patient care and safety.

This cross-sectional and correlational study seeks to fill the gap in the literature by examining the specific effects of workload and fatigue on sleep perception among OR nurses. By identifying these relationships, the study aims to contribute valuable insights into strategies for mitigating fatigue and improving sleep among this critical group of healthcare workers, with the ultimate goal of ensuring both nurse well-being and patient safety.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Nurses who have been working as operating room nurses in the hospitals where the study is conducted for at least one year, Nurses who are willing to participate in the study will be included.  Exclusion Criteria:  Data from nurses who wish to withdraw from the study at any stage will be excluded from the research. - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: The study focuses on operating room (OR) nurses with at least one year of experience in various hospitals. These participants are chosen for their specialized knowledge in the surgical environment, ensuring they provide insights into workload, fatigue, and sleep quality. Inclusion is based on voluntary consent, aiming to collect data from a group well-versed in the unique challenges and stressors of OR settings. This demographic is particularly valuable for exploring how their demanding roles affect sleep and well-being. - SamplingMethod: Non-Probability Sample
the Impact of Manual or Mechanical Ways to Perform PLR on the Accuracy of Evaluation of Fluid Responsiveness
Status: Recruiting

Our goal was to study the impact of different ways to perform passive leg raising (PLR) on the accuracy of evaluation of fluid responsiveness.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  (1) patients who appear to be of volume deficiency during postoperative period (increasing lactate levels, in need of vasopressor agents to maintain blood pressure, oliguria, and weak consciousness), and need to evaluate their fluid responsiveness; (2) patients who have undergone cardiac thoracotomy surgery; (3) patients who are transferred into the intensive care department for monitoring after surgery.  Exclusion Criteria:  (1) Age < 18 years old, or > 75 years old (2) pregnancy or lactation; (3) refusal to sign the informed consent form for enrollment; (4) patients who are clearly unable to perform passive leg raising (PLR) (intra-abdominal pressure ≥16cmH2O, high risk of lower limb venous thrombosis, intracranial hypertension, and recent undergone abdominal or pelvic surgery); (5) patients with the contraindications of using ICON Cardiac Monitor ( patients with a rate-responsive implantable cardiac pacemaker which uses electrical impedance measurements to obtain minute ventilation, patients currently undergoing external defibrillation therapy, patients using high-frequency oscillation ventilation, patients with artificial heart or heart assist device like IABP or VA-ECMO); (6) patients with the contraindications of fluid resuscitation therapy ( pulmonary edema, intracranial hypertension and so on); (7) patients who underwent partial aortic resection with artificial vessel replacement surgery ( such as after aortic aneurysm or aortic dissection vessel replacement surgery); (8) patients clinical doctors assessed as unsuitable for PLR. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult
A Study of Clinical Outcomes in Patients With Relapsed/Refractory Multiple Myeloma (RRMM) Treated With T-cell Redirectors Outside of Clinical Trials
Status: Recruiting

The purpose of this study is to describe the use of teclistamab in the treatment of patients with RRMM outside of clinical trials.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Have a documented diagnosis of multiple myeloma Received the first dose of teclistamab on or before 31 December 2022, regardless of the duration of teclistamab treatment Received at least one dose of teclistamab Provision of a patient-signed informed consent form (ICF), or an ICF waiver for deceased patients as applicable based on country/site-specific requirements  Exclusion Criteria:  Received teclistamab as part of an interventional clinical trial - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Study population include patients who have initiated the treatment with T-cell redirectors outside of a clinical trial setting. - SamplingMethod: Non-Probability Sample
Surgical ICU Nurses' Attitudes on End-of-Life Care
Status: Not yet recruiting

This study aims to explore the attitudes and behaviors of nurses working in surgical intensive care units (ICUs) towards end-of-life care, alongside identifying the barriers they face in providing such care. Despite the universal need for end-of-life care, with an estimated 56.8 million people requiring it annually, only a fraction receive adequate services. The concept of a "good death" has evolved, now emphasizing patient and family wishes, and aligning with clinical, cultural, and ethical standards. In the U.S., a significant portion of deaths occur in hospitals, often involving surgical interventions in the final stages of life. Nurses in ICUs play a crucial role in delivering end-of-life care, making their attitudes and behaviors pivotal to the quality of care provided. Previous studies have indicated a positive correlation between nurses' attitudes towards end-of-life care and their ethical conduct in care delivery. However, research specifically focusing on surgical ICU nurses and the challenges they encounter in end-of-life care is limited. This study seeks to fill that gap, enhancing understanding of the factors that influence end-of-life care in surgical ICUs and potentially guiding improvements in care practices and policy.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Nurses working in the Surgical Intensive Care Unit, Nurses willing to participate in the study will be included.  Exclusion Criteria:  Nurses who wish to withdraw from the study at any stage after being included will not have their data included in the research. - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: The study population consists of nurses employed in Surgical Intensive Care Units (SICUs) who have voluntarily agreed to participate in this research. This group is targeted due to their direct involvement and experience with end-of-life care practices within a highly specialized and critical care environment. The inclusion of SICU nurses allows for a focused examination of the attitudes, behaviors, and perceived barriers towards end-of-life care in a setting that frequently confronts the complexities of life-threatening conditions and death. This specific population provides valuable insights into the challenges and needs associated with end-of-life care in surgical intensive care contexts, contributing to the development of more effective care strategies and policies to support both patients and healthcare professionals in this sensitive area of medical care. - SamplingMethod: Non-Probability Sample
Nursing Students' Perceptions and Participation in Surgical Clinical Learning
Status: Not yet recruiting

This cross-sectional study investigates the perceptions of nursing students regarding the clinical learning environment (CLE) in surgical services and their participation in clinical practices. Surgical services present a complex, dynamic, and intense learning environment crucial for the development of nursing students' professional competencies. The study explores the challenges nursing students face in these settings, including limited opportunities for participation in intraoperative processes and intensive care units, and the impact of these challenges on their learning outcomes and professional development.

Previous research has highlighted various factors that can either facilitate or hinder nursing students' ability to engage effectively in clinical practices, such as the learning atmosphere, support from nurse educators, peer support, and effective communication. However, there is a noted gap in understanding the specific difficulties encountered in surgical services, the adequacy of students' clinical skills and knowledge, and their ability to apply theoretical knowledge in practice.

By examining nursing students' experiences, this study aims to shed light on the suitability and quality of CLEs in surgical services, contributing valuable insights for optimizing clinical learning and enhancing nursing education programs. The hypotheses tested whether nursing students' perceptions of CLEs in surgical services and their participation in clinical practices are influenced by their descriptive characteristics.

Keywords: Nursing Student, Surgical Services, Clinical Practice, Clinical Learning Environment

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Nursing students taking a surgical course for the first time, Those who are not graduates of a vocational health high school, Those not working as health professionals, Nursing students willing to participate in the study were included.  Exclusion Criteria:  Students who wished to withdraw from the sample at any stage of the research were excluded from the study - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: The study population consists of nursing students enrolled in a surgical nursing course for the first time, excluding those with a vocational health high school background or current healthcare professionals. This selection aims to ensure participants have similar educational experiences and are in a critical phase of integrating theoretical knowledge with practical skills. Focusing on students not yet working in health services allows for a clearer assessment of educational impacts without professional biases. Participation is voluntary, emphasizing engaged learners likely to provide insightful feedback on their clinical learning environment in surgical settings. This approach aims to identify educational facilitators and barriers within a specific, challenging clinical context. - SamplingMethod: Non-Probability Sample
miroliverELAP® for the Treatment of Acute Liver Failure: A Phase 1 Trial
Status: Not yet recruiting

The clinical trail will assess the safety of miroliverELAP for the treatment of acute liver failure without underlying chronic liver disease. miroliverELAP is an external liver assist combination product consisting of a single-use MIRO-001 bioengineered liver graft and an extracorporeal blood circuit. miroliverELAP Is intended to support the native (failed) liver for up to 48-hours of continuous treatment to allow time for liver recovery or to identify a transplantable liver.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  8 years to 80 years old at the time of signing the informed consent  Subject must:  be deemed competent to consent by an independent qualified practitioner, or have consent given by a Legally Authorized Representative  Be diagnosed with acute liver failure as defined as:  INR ≥ 2.5, and Hepatic Encephalopathy Grade II-III (West Haven Criteria), and Less than 4 weeks (28 days) of disease duration Subject is not a candidate for liver transplant and will not become a candidate in the event of worsening conditions.  Exclusion Criteria  Underlying chronic liver disease, including:  Acute-on-chronic liver disease Acute alcoholic-associated hepatitis Cirrhosis Grade IV West Haven Encephalopathy Criteria Previous liver transplant Currently requires chronic hemodialysis Uncontrolled- documented infection, hypotension or refractory shock Liver injury due to trauma Any current liver cancer Currently on medications with a narrow therapeutic index, as defined in Section 11.10.1 Platelet count < 40,000 μL If the subject is intubated and has an acute lung injury  Experiencing a bleeding event, defined as:  Active gastrointestinal or other overt bleeding event, or Hemoglobin drop > 3g/dL within the past 24 hours, or Received ≥ 3 units of red blood cell transfusion within the past 24 hours Female that is currently pregnant, planning to be pregnant, or currently breastfeeding Refusal to receive blood products - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult