rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
Influence of an Inspiratory Muscle Fatigue Protocol on Older Adults on Respiratory Muscle Strength, Muscle Oxygen Saturation, and Functional Capacity
Status: Not yet recruiting

Respiratory muscle training represents an effective method increasingly utilized in both sports and healthcare domains, employing various devices, among which threshold devices are prominent. The aim of this study is to determine the relationship between diaphragmatic fatigue and muscular strength in upper and lower limbs, in both healthy and pathological subjects, as well as the association between such fatigue and other variables, including maximal inspiratory pressure, functionality and muscle tissue oxygen levels.

According to our hypothesis, the execution of a protocol inducing diaphragmatic fatigue in older adults could influence muscular strength, cardiorespiratory function, exercise capacity, and muscle tissue oxygenation.

In this study, subjects will be divided into three groups: the experimental group , the activation group and the control group.

Measurements of variables, such as maximal inspiratory pressure, peripheral muscle tissue oxygen levels, diaphragmatic strength (ultrasound image) and functional capacity, will be conducted.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  • Being over 60 years old.  Physical independence in terms of gait and transfers  Exclusion Criteria:  Having any pathology that prevents the performance of physical activity.  Subjects with impaired cognitive abilities. Subjects with tympanic perforation or middle-inner ear pathology. Subjects with pulmonary hypertension, decompensated heart or respiratory failure. Subjects who have undergone lower limb surgery within the past 12 months. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 60 Years - MaximumAge: 99 Years - StdAgeList: Adult, Older Adult
Comparison of 2 Extracts of Saw Palmetto Versus Placebo on BPH Symptoms
Status: Not yet recruiting

A randomized, double-blind, placebo-controlled, parallel group study to compare 2 extracts of saw palmetto versus placebo on the symptoms of benign prostate hyperplasia (BPH) in 120 generally healthy participants, 45 - 80 years.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Male aged between 45-80 Medically diagnosed with BPH (Participant to provide written evidence of medical diagnosis) Score of 12-19 in the IPSS (moderate) Generally healthy Able to provide informed consent Agree not to participate in another clinical trial while enrolled in this trial Agree not the change their diet or exercise while enrolled in this trial  Exclusion Criteria:  Serious illness e.g., mood disorders such as depression, anxiety or bipolar disorder, neurological disorders such as MS, kidney disease, liver disease or heart conditions (A serious illness is a condition that carries a risk of mortality, negatively impacts quality of life and daily function and/or is burdensome in symptoms and/or treatments) Unstable illness e.g., diabetes and thyroid gland dysfunction (An unstable illness is any illness that is currently not being treated with a stable dose of medication or is fluctuating in severity) Have used a drug/natural therapy for BPH or other urological symptoms within the last 30 days? Have had a urinary infection in the last 30 days or have, chronic urinary tract infections, or diagnosed chronic prostatitis Have had urogenital surgery within the last 6 months. Have had a bladder biopsy and/or cystoscopy and biopsy within the past 30 days. Have been diagnosed with chronic persistent local pathology (e.g. interstitial cystitis, bladder stones) Receiving/ prescribed Coumadin (Warfarin) or other anticoagulation therapy Diagnosed genital anatomical deformities, uncontrolled diabetes mellitus, and history of spinal cord injury, uncontrolled psychiatric disorder, and/or abnormal secondary sexual characteristics. Diagnosed cancer including prostatic cancer; if suspected by the investigator, refer for medical assessment Active smokers and/or nicotine or drug abuse Chronic alcohol use (>14 alcoholic drinks week) Allergic to any of the ingredients in investigational, comparator or placebo formula Any condition which in the opinion of the investigator makes the participant unsuitable for inclusion Participated in any other clinical trial during the past 1 month - HealthyVolunteers: No - Gender: Male - MinimumAge: 45 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult
Comparsion Between Intravenous Infusion of Ketofol and Inhalational Anasthetics in Abdominal Cancer Surgeries for Post Operative Analgesia
Status: Not yet recruiting

( post operative pain between intravenous infusion ketofol and standard inhalational general anesthesia in abdominal cancer surgeries )

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  a. Inclusion criteria:  Age group 18 - 60 years old. Both gender ASA 1and 2  Exclusion Criteria:  a. Inclusion criteria:  Age group 18 - 60 years old. Both gender ASA 1and 2 b. Exclusion criteria: Patient refusal, History of cardiac or respiratory disease, psychological disorders,  High risk of regurgitation or aspiration based on a history of diabetes,  hiatus hernia, gastroesophageal reflux, and obesity,  neck pathology, Predicted difficult airway (history of difficult airway, mouth opening - Gender: All - StdAgeList: Child, Adult, Older Adult - StudyPopulation: Inclusion Criteria:  a. Inclusion criteria:  Age group 18 - 60 years old. Both gender ASA 1and 2  Exclusion Criteria:  a. Inclusion criteria:  Age group 18 - 60 years old. Both gender ASA 1and 2 b. Exclusion criteria: Patient refusal, History of cardiac or respiratory disease, psychological disorders,  High risk of regurgitation or aspiration based on a history of diabetes,  hiatus hernia, gastroesophageal reflux, and obesity,  neck pathology, Predicted difficult airway (history of difficult airway, mouth opening - SamplingMethod: Probability Sample
Effect of Diaphragmatic Breathing Exercise on Fatigue and Quality of Life in Pregnant Women With Gestational Diabetes
Status: Not yet recruiting

Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy. GDM, which is in the high-risk pregnancy category, causes fatigue during pregnancy due to both hormonal changes and pregnancy complications (1). Fatigue is a general complaint that occurs in almost all physical and mental diseases. Fatigue also negatively affects an individual's well-being, daily performance, activities of daily living (ADLs) and relationships. Fatigue is one of the symptoms that, if not controlled, negatively affects the individual's daily living activities and quality of life (2). While breathing itself is a way of relaxation, it is also a part of all relaxation exercises and is an exercise that can be used in daily life. Breathing correctly and deeply is the first step in learning to relax. (3). It is important to identify fatigue, minimize it, plan daily living activities and improve quality of life in patients with GDM. This study will be conducted as a randomized controlled study to determine the fatigue and quality of life of diaphragmatic breathing exercises, one of the non-pharmacological methods, on pregnant women with gestational diabetes.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Being between the ages of 19-35, 24-28. During the pregnancy week, Being a single and live fetus, No reading and writing problems, no mental disabilities or communication problems.  Exclusion Criteria:  Multiple pregnancy, Fetal congenital malformation, Having a diagnosed disease other than GDM There is a risk of miscarriage during pregnancy, - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - GenderBased: Yes - MinimumAge: 19 Years - MaximumAge: 35 Years - StdAgeList: Adult
Cerebellar rTMS in Patients With Multiple Sclerosis
Status: Not yet recruiting

To determine the efficacy of high frequency cerebellar repetitive transcranial magnetic stimulation on coordination in patients with multiple sclerosis.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Clinically definite MS (relapsing, remitting and secondary progressive) patients Patients who are medically stable and Free from relapses three months before Ambulant patients without an assistive device and score less than 5 on the Kurtzke Expanded Disability Status Scale (EDSS) Patients receiving their disease modifying drugs but no medication changing during the previous three months. Patients who had MRI evidence of lesions in the cerebellum or in the cerebellar pedunculi. Right handed patients. Severity of ataxia range from 4 to 10 according to scale of assessment and rating ataxia (SARA). Did not apply cerebellar transcranial magnetic stimulation before.  Exclusion Criteria:  Any other neurological deficits or orthopedics abnormalities. Ataxic manifestations for other cause rather than Multiple Sclerosis. Other neurological manifestations (e.g. spasticity, visual loss) Secondary musculoskeletal complication such as contractures or deformities. Cardiovascular, pulmonary, hepatic, renal, hemopoietic and thyroid diseases. Pregnant women. Addicted individuals. Previous surgeries in the brain. Any magnetic or metallic devices implanted (like cochlear implants) . Psychotic deficits or history of epileptic seizures. - HealthyVolunteers: No - Gender: All - MinimumAge: 20 Years - MaximumAge: 45 Years - StdAgeList: Adult
Effect of Kinesiotaping on Activation of Abdominal Muscles in Female Patients With Stress Urinary Incontinence
Status: Not yet recruiting

This study will be conducted to evaluate the effect of kinesiotaping on activation of abdominopelvic cavity for management of stress urinary incontinence females' patients.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Women suffering from mild to moderate stress urinary incontinence, clinically diagnosed by the gynecologist. Their ages will be ranged from 30-50 years old. Their body mass index (BMI) will be ranged from (20-25 kg/m2). They shouldn't have any musculoskeletal or neurological disorders.  Exclusion Criteria:  Current pregnancy. Malignant condition History of acute infection Neurological problem Mental problem to prevent evaluation and cooperation Having allergies to kinesiotaping Having uncontrolled metabolic diseases like diabetes and thyroid disease. Athletic females - HealthyVolunteers: No - Gender: Female - GenderBased: Yes - MinimumAge: 30 Years - MaximumAge: 50 Years - StdAgeList: Adult
Specific Versus Empirical Anthelminthic Treatment in Eosinophilia
Status: Not yet recruiting

There are a few guidelines recommend about management of eosinophilia worldwide, most of guielines recommend a thorough history-taking and physical examination. Subsequently, investigations are requested based on suspected causes. In cases where parasite infection is suspected, particularly in developing countries, stool microscopy and serology are recommended. However, limitations such as low sensitivity of stool microscopy, the inconvenience of collecting multiple stool samples, and the high cost and unavailability of serology may arise. Consequently, some physicians opt for empiric anthelminthic regimens in managing eosinophilic patients, even without stool tests or if stool test results are normal. If subsequent complete blood count (CBC) results show a recovery of absolute eosinophil count, it is assumed that eosinophilia was caused by a parasite infection. While some studies demonstrate the efficacy and simplicity of this approach, there is a risk of overestimating parasite infection in eosinophilic patients, potential adverse drug reactions from unnecessary anthelminthic treatment, and the possibility of drug resistance due to inappropriate dosing. To address this gap, no study has yet compared the efficacy between specific anthelminthic treatment based on test results and empirical anthelminthic treatment in eosinophilic patients. Therefore, the investigators are conducting this study.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Participants who come for check-ups at general practitioner, primary care unit, and Srivejchavat Premium Center have an absolute eosinophil count greater than 500 cells/microliter with a white blood cell count less than 10,000 cells/microliter. Age at least 18 years old Consent to participate in research  Exclusion Criteria:  Having any characteristics that need urgent care 1.1 Having history of unintended significant weight loss is defined as the loss of body weight exceeding 10% within a span of six months without deliberate attention.  1.2 Physical examination revealed a body temperature equal to or greater than 37.8 degrees Celsius, lymphadenopathy or hepatosplenomegaly.  1.3 CBC revealed blast cell  Receiving anthelminthic drug within 6 months Underlying cancer (active stage), HIV, HBV, HCV, collagen vascular disease, active TB Allergy to albendazole, ivermectin, or metronidazole Pregnancy or lactation Serum transaminase higher than 2 times of upper normal limit Taking medications that may induce eosinophilia within the past three months, such as herbal supplements, NSAIDs, Salicylic acid, Carbamazepine, Colchicine, Nitrofurantoin, Dapsone, or Minocycline, was reported. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Effect of Multifunctional Nutrition Tube on Cerebral Small Vessel Disease Patients
Status: Recruiting

Nasogastric tube feeding (NGT) has been widely used in cerebral small vessel disease (CSVD) patients with dysphagia but has a significant risk of complications. Intermittent Oro-esophageal Tube Feeding (IOE) is an established enteral nutrition approach that can be used with comprehensive rehabilitation therapy. This study aims to explore the clinical effect of IOE vs. NGT on CSVD Patients with Dysphagia. Compared to NGT, IOE, as an enteral nutrition support mode, in CSVD Patients with Dysphagia who received comprehensive rehabilitation therapy, showed advantages in improvement in dysphagia, nutritional status, ADL, QOL, pneumonia, and adverse events, which should be considered as the preferred approach.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Clinical diagnosis of CSVD, confirmed by MRI; Must be able to cooperate with treatment and questionnaire investigation, (Generally with a Mini-Mental State Examination (MMSE) score ≥ 24) ; Clinical diagnosis of dysphagia through the Functional Oral Intake Scale (FOIS) and Video Fluoroscopic Swallowing Study (VFSS); Age between 40 and 70 years; Enteral nutrition support was required and feasible. No history of prior stroke.  Exclusion Criteria:  Dysphagia related to other cerebrovascular diseases or caused by neurodegenerative diseases; Complicated with severe liver and kidney failure, tumors, or hematological disorders; Simultaneously need to undergo other therapy that might affect the outcomes of this study; Pregnant or nursing females. - HealthyVolunteers: No - Gender: All - MinimumAge: 40 Years - MaximumAge: 70 Years - StdAgeList: Adult, Older Adult
Multifunctional Nutrition Tube in Dysphagia for Nasopharyngeal Carcinoma
Status: Recruiting

This is a prospective multicenter study with patients with delayed dysphagia after radiotherapy for NPC. Patients enrolled are randomly divided equally into the observation group and the control group. All patients receive conventional care, and the observation group received IOE while the control group received NGT for enteral nutrition support. Baseline information (demographics, medical history, etc.), nutritional status at admission and after treatment, depression, dysphagia, and quality of life (QOL) after treatment as well as adverse events are compared.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age between 18 and 65 years. With the history of NPC and radiation therapy. With dysphagia occurred at least three years after radiotherapy (confirmed by videofluoroscopic swallowing study), in need of and feasible for enteral nutrition support. Conscious and with stable vital signs; Willing to participate and sign the written informed consent form either personally or by a family member.  Exclusion Criteria:  Presence of other diseases that might cause dysphagia. With distant metastasis of tumors, or complicated with severe systemic disorders or malignancies. Concurrent participation in other treatments that could interfere with the trial. Inability to cooperate with treatment due to aphasia, mental health issues, etc. Received tube feeding for enteral nutrition support within the past three years. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult
The Effect of Active Breathing Exercises in Stroke Patients With Respiratory Rhythm Disorder
Status: Recruiting

The goal of this clinical trial is to explore The Effect of Active Breathing Exercises in Stroke Patients With Respiratory Rhythm Disorder. Patients will be randomly divided into an observation group and a control group, all receiving routine rehabilitation treatment. On this basis, the observation group will be given Active Breathing Exercises. Researchers will compare dysphagia of two groups.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  diagnosed with Respiratory Rhythm Disorder age ≥ 18 years; meeting the diagnostic criteria of stroke; any degree of dysphagia at admission; steady vital signs, without severe cognitive impairment or sensory aphasia, able to cooperate with the assessment. transferred out within three weeks of hospitalization in the neurology department.  Exclusion Criteria:  complicated with other neurological diseases; tracheostomy tube plugged; unfeasible to the support of parenteral nutrition; simultaneously suffering from liver, kidney failure, tumors, or hematological diseases. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Effect of Different Feeding Modes on Psychological Condition and Experience in Stroke Patients
Status: Recruiting

The goal of this clinical trial is to compare the differences on Psychological Condition and Experience in ischemic stroke patients using Intermittent Oro-esophageal Tube and Nasogastric Tube. Patients will be randomly divided into an observation group and a control group, all receiving routine rehabilitation treatment. On this basis, the observation group will use Intermittent Oro esophageal Tube for enteral nutrition support, while the control group will use Nasogastric Tube. Researchers will compare Psychological Condition and Experience of two groups.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age>18 years. Meeting the diagnostic criteria for ischemic stroke . Dysphagia confirmed by Videofluoroscopic Swallowing Study. Clear consciousness. Stable vital signs.  Exclusion Criteria:  Dysphagia that might be caused by other diseases that might cause dysphagia, such as head and neck tumors, traumatic brain injury, myasthenia gravis, etc. Complicated with severe liver and kidney failure, tumors, or hematological disorders. Simultaneously in need to undergo other therapy that might affect the outcomes of this study. Pregnant or nursing females. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Efficacy of Stellate Ganglion Block in Obstructive Sleep Apnea
Status: Not yet recruiting

The goal of this clinical trial is to test the efficacy of stellate ganglion block in Obstructive Sleep Apnea. The main question it aims to answer are:

• Can stellate ganglion block improve Obstructive Sleep Apnea? Patients were randomly divided into two groups, all provided with routine therapy. Based on this, the experimental group was given stellate ganglion block. The video fluoroscopic swallowing study was done to test the swallowing function before and after the study.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients aged over 18 years diagnosed with OSA by polysomnography Patients with moderate to severe OSA (AHI > 15 events per hour) Patients who have undergone continuous positive airway pressure (CPAP) treatment for at least 3 months but have not achieved satisfactory therapeutic effects Patients who voluntarily agree to receive stellate ganglion block (SGB) treatment and sign the informed consent form  Exclusion Criteria:  Patients with a history of allergy or contraindications to local anesthetics or corticosteroids Patients with severe cardiovascular, cerebrovascular, respiratory, hepatic, or renal diseases Patients with a history of neck surgery or cervical spine disease Patients with psychiatric disorders or other medical conditions that may affect the safety or effectiveness of SGB treatment Pregnant or lactating women Patients who have participated in other clinical trials within the past 3 months - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Transcranial Direct Current Stimulation Combined With Intermittent Oral to Esophageal Tube on Dysphagia
Status: Recruiting

The study is a double-blind randomized controlled trial, lasting for 15 days for each participant. Patients with post-stroke dysphagia who receive treatment at the Rehabilitation Department are selected as the study subjects. The patients are randomly assigned to either the experimental group or the placebo group. All patients receive routine rehabilitation therapy and swallowing rehabilitation training, along with enteral nutrition support using Intermittent Oro-esophageal Tube. In addition to these interventions, patients in the experimental group receive transcranial direct current stimulation, while the instruments used for patients in the placebo group only illuminate an indicator light without any actual effect.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Meet the diagnostic criteria for ischemic stroke confirmed by MRI or CT; Age > 18 years; First-time stroke; Swallowing disorder confirmed by swallowing contrast study or flexible endoscopic evaluation of swallowing; Requires enteral nutrition support; Stable vital signs, no severe cognitive impairment or aphasia, able to cooperate with treatment; Transferred to the rehabilitation department within fifteen days of onset; Stable vital signs.  Exclusion Criteria:  Presence of contraindications for invasive oral endoscopy; Concurrent presence of other neurodegenerative diseases that may cause swallowing disorders, such as neurodegenerative diseases; Concurrent presence of other neurological disorders; Tracheostomized patients; Concurrent liver, kidney failure, tumor, or hematological disorders; Pregnancy; Presence of contraindications for transcranial direct current stimulation, such as epilepsy, cerebral edema; Recent use of centrally acting drugs that interfere with the effects of transcranial direct current stimulation, such as carbamazepine, phenytoin, valproic acid, etc. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult