rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
Negative Serology by Immunoenzymatic Test (EIA) in HIV-infected Children Treated Early With Antiretroviral in the ANRS-Pediacam Study: Pathophysiological Mechanisms
Status: Not yet recruiting

The objective of the study is to identify the pathophysiological mechanisms responsible for the induction and maintenance of negative serologies by EIA tests in HIV-infected children treated early with HAART in the ANRS 12225-Pediacam III cohort in Cameroon

The hypothesis of better control of HIV infection through interactions between immunological, viral, and genetic factors was made to build the following objectives:

Immunological aspect: lack of humoral response or immune activation
Virological aspect: Reduced HIV reservoir size
Determine the HLA phenotype in the different groups of children included and the KIR genotypes.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Case control study  Children included and followed in the ANRS 12225 study - Pediacam III Having plasma samples in the bio bank during the above-mentioned periods Case:children with at least one negative HIV serology made by ELISA, permanent or transientduring follow-up.  Control (4 groups)  HIV-infected children with positive serology and viral load (VL) <400 copies /ml HIV-infected children with positive serology and VL ≥400 copies / ml HIV-uninfected children born to HIV-positive mothers HIV-uninfected children born to HIV-uninfected mothers Selection of cases and controls will be matched on gestational age (premature <37, term ≥37 weeks) and year of birth (2007-2008 and 2009-2010).  Cross sectional study Inclusion criteria  All children still followed in the ANRS - Pediacam III cohort Written consent of one of the parents or the guardian and assent of the child if aged ≥ 11 years and complete disclosure of HIV statusfor infected children for participation to the study.  Exclusion Criteria:  Refusal by one of the parents or the guardian for the child's participation in the study No assent of the child (if aged ≥ 11 years and with complete disclosure of HIV status, for infected children) - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - StdAgeList: Child, Adult, Older Adult
Effect of Kinesiotaping on Pain,Edema and Kinesiophobia in Patients With Complex Regional Pain Syndrome
Status: Not yet recruiting

Patients will be divided into 2 groups according to the random numbers table, and both groups will receive a conventional physical therapy and rehabilitation program and nutritional support. Afterwards, edema-reducing kinesiotaping will be applied to one group. The applied kinesio tape will remain on the patient for 5 days and will be taped again after 2 days without tape. In this way, taping will be done 3 times in total, once a week for 3 weeks. During this period, patients will continue their routine physical therapy program and measurements will be taken by the same researcher in the 1st week of treatment and 3 weeks later.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Clinical diagnosis of reflex sympathetic dystrophy Ability to be included in a physical therapy program  Exclusion Criteria:  Hemiplegia Malignancy Polyacrylamide allergy Open wound in the area to be applied - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult
Telemedicine-Based Virtual Reality Clinic for the Treatment of Phobias
Status: Recruiting

The purpose of this study is to assess the feasibility of conducting a randomized controlled efficacy trial comparing the delivery of exposure therapy via a telemedicine-based virtual reality clinic (Doxy.me VR) vs. standard telemental health (TMH) to adults with intense fear of dogs, snakes, and/or spiders. The secondary purpose is to preliminarily examine the efficacy of using Doxy.me VR vs. TMH in reducing phobia severity.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  In order to be eligible to participate in this study, an individual must meet all of the following criteria:  Is an adult ≥ 18 years old Has a self-reported fear of dogs, snakes, and/or spiders Indicates Subthreshold or Present Specific Phobia symptoms as determined by the study therapist via administration of the Diagnostic Assessment Research Tool (DART) Specific Phobia Module Has access to the internet AND a computer OR smartphone with video conferencing capabilities Will reside in the state of Florida for the duration of the study  Exclusion Criteria:  An individual who meets any of the following criteria will be excluded from participation in this study:  Is participating in ongoing mental health therapy from a non-study therapist Has had changes to psychotropic medication use within six weeks preceding enrollment in the trial Reports active suicidal and/or homicidal intent or plan as determined by the study therapist via administration of the Diagnostic Assessment Research Tool (DART) Risk Assessment Module Reports active auditory, visual, and/or tactile hallucinations via the Diagnostic Assessment Research Tool (DART) Psychosis Module screening question Reports a history of epilepsy or seizures - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Exploring Adherence and Knowledge Among Diabetic Individuals in Periodontal Care
Status: Not yet recruiting

Objective(s) The primary objective is to evaluate the adherence of diabetic patients to periodontal care, accomplished either through oral communication (group A, control) or through a photograph of their smile, and focusing on their gum health evaluated by a periodontist (group B, test).

Secondary objectives include assessing the prevalence of periodontal disease (PD) in this diabetic sample population and evaluating the presence of specific biomarkers related to it.

The final objective is to assess the agreement between the diagnosis of periodontitis based on the photographs and the diagnosis given after the dental visit, based on the clinical examination. The aim is to determine if the photos could potentially serve as a reliable indicator for periodontal risk assessment.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Type 1 or type 2 diabetes  Exclusion Criteria:  last dental visit<1 year patient unable to give consent - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Comparison of IMES Versus DN on ATrPs of AC
Status: Recruiting

The aim of our study to compare DN and IMES for pressure pain threshold, ROM and the shoulder function in active trigger points with adhesive capsulitis. This study will add to the growing body of knowledge that if these two techniques yield comparable outcomes and if one technique is superior to the other, which should be the alternative of therapy. Moreover, it would add to the society as there are very limited researches done in Pakistan using needling for trigger points in adhesive capsulitis.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  • Age 40 to 60 year of both genders  Diagnosed patients of stage 3 Adhesive capsulitis with type I and II diabetes Involvement of at least 3 shoulder girdle muscles in Active MTrPs (subscapularis, latissimus dorsi, deltoid (anterior, middle, posterior) Active MTrPs in shoulder girdle muscles (subscapularis, supraspinatus, deltoid (anterior, middle, posterior), teres minor, latissimus dorsi) Reproduction of the patient's symptoms at active trigger point, Taut band, Hypersensitive spot, Referred pain pattern, local twitch response Minimum 60 degrees of active/passive shoulder abduction range of movement.  Exclusion Criteria:  Systemic inflammatory joint disease of shoulder joint (RA, OA polymyalgia rheumatic) Cerebral Vascular Accident Fibromyalgia, neurological deficits of upper limb (Nerve root entrapment, Cervical radiculopathy, Thoracic outlet syndrome) History of Fracture, Dislocation, Acute soft tissue injury, Acute bursitis Avascular necrosis of humeral head or visceral referred pain to shoulder Pregnancy, Hypothyroidism, skin infection Patients who are using Antiplatelet Therapy with in past 3 days of study Extreme fear of needles - HealthyVolunteers: No - Gender: All - MinimumAge: 30 Years - MaximumAge: 60 Years - StdAgeList: Adult
Effects of Tupler and Scoop Exercises in Diastasis Recti
Status: Recruiting

To compare the effects of tupler and scoop exercises on inter recti distance, low back pain, abdominal strength and urogynecological symptoms in diastasis.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  BMI 25kg|m^2 to 30kg\m^2or greater multiparous women Participants included will be 3 months post-partum females Caesarean delivery who will have with the presence of DRA >2 finger width and >2cm  Exclusion Criteria:  patients who had hernia trauma to bowel or bladder malignancies neurologic disease and its associated balance disorders, pelvic or abdominal surgery (except for a caesarean section) were considered as the exclusion criteria of this study - HealthyVolunteers: No - Gender: Female - GenderBased: Yes - GenderDescription: DIASTASIS - MinimumAge: 18 Years - MaximumAge: 40 Years - StdAgeList: Adult
Modified Intermittent Eating on Weight Loss (INTEREST-3 Trial)
Status: Not yet recruiting

Obesity is becoming a major global public health issue. Calorie restriction (CR) is the most important treatment for weighting loss. In recent years, two novel types of intermittent fasting recently have gained more attention: the 5:2 diet and time-restricted eating (TRE). TRE requires individuals to eat in a specified number of hours per day (typically 4 to 10 hours) without energy intake restriction. The 5:2 diet involves 5 feast days and 2 fast days per week; participants eat ad libitum without restriction on feast days while 25% of energy needs (approximately 500-800 kcal per day) are consumed on fast days. However, the effects of dietary strategy of intermittent fasting plus time-restricted eating (modified time-restricted eating: TRE 5 days and fasting 2days per week) on weight loss and cardiometabolic risk factors in obese adults have not been proved. This randomized controlled trial aimed to evaluate the effect of modified time-restricted eating (mTRE) and CR on weight loss and cardiometabolic risk factors in obese adults compared to usual health care over 12 months.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Man or women aged 18-75 years; Body mass index (BMI)of 28.0 to 45.0 kg/m2;  Exclusion Criteria:  History of HIV, hepatitis B or C (self-report) or active pulmonary tuberculosis; Diagnosis of type 1 and type 2 diabetes; History of malignant tumors; Serious liver dysfunction or chronic kidney disease (AST or ALT > 3 times the upper limit of normal, or eGFR<30 ml/min/1.73 m2); History of serious cardiovascular or cerebrovascular disease (angina, myocardial infarction or stroke) in the past 6 months; History of severe gastrointestinal diseases or gastrointestinal surgery in the past 12 months; History of Cushing's syndrome, hypothyroidism, acromegaly, hypothalamic obesity; Being a smoker or having been a smoker in the 3 months prior to their screening visit; Taking medications affecting weight or energy intake/energy expenditure in the last 6 months, including weight loss medications, antipsychotic drugs or other medications as determined by the study physician; Currently participating in weight loss programs or weight change in the past 3 months (> 5% current body weight) ; Women who are pregnant or plan to become pregnant; Patients who cannot be followed for 24 months (due to a health situation or migration); Patients who are unwilling or unable to give informed consent. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult
Examination of the Acute Effect of Mollii Suit in Children With Cerebral Palsy
Status: Recruiting

The aim of our study is to examine the acute effect of Mollii Suit application on balance and muscle tone problems in children with spastic cerebral palsy.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  volunteering to participate in the study Having a diagnosis of spastic CP 1 or 2 on the Gross Motor Classification System (GMFCS) Between the ages of 4-18.  Exclusion Criteria:  Having GMFCS 3,4,5 Botulinum Toxin A performed before 3 months or surgical intervention before 6 months Having an invasive medical pump (baclofen, insulin, etc.) - HealthyVolunteers: No - Gender: All - MinimumAge: 4 Years - MaximumAge: 18 Years - StdAgeList: Child, Adult
MAIN-IMAGE Registry
Status: Recruiting

All comers registry with patients with chronic coronary syndrome or acute coronary syndrome who underwent intracoronary imaging during cardiac catherization. The aim is to identify plaque characteristics on OCT or IVUS that are associated with adverse cardiac events including myocardial infarction and atherosclerotic progression.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  patients undergoing pre-intervention optical coherence tomography imaging  Exclusion Criteria:  - - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: ACS or SAP patients - SamplingMethod: Non-Probability Sample
Emergency Medical Staff Workload Analysis
Status: Recruiting

The aim of this study is to identify trauma determinants and leverage this understanding to develop solutions applicable to the prevention and treatment of PTSD among emergency medical personnel. By categorizing stimuli associated with traumatic professional experiences, the study aims to enhance existing therapeutic protocols through exposure therapy. The specific objectives are as follows:

Analysis and characterization of occupational workloads among doctors and emergency medical personnel, focusing on the scale of burdens associated with PTSD symptoms.
Development of categories for aggravating and potentially traumatizing stimuli within the medical staff of rescue teams.
Examination of the feasibility of incorporating the obtained results into cognitive-behavioral therapy protocols.
Assessment of the potential for implementing the results in solutions utilizing virtual reality technology.
Formation of an interdisciplinary international research team.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  completed medical studies or emergency medical course assistance in life-threatening conditions  Exclusion Criteria:  Intellectual disability Inability to self-complete the research questionnaires - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 21 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Medical staff involved in treating life-threatening conditions - SamplingMethod: Non-Probability Sample
A Mobile Application to Improve Postoperative Outcomes in Colorectal Cancer
Status: Recruiting

The unplanned readmission rate after colorectal cancer surgery is still high, despite the implementation of enhanced recovery programs. The use of a mobile-based application for perioperative remote monitoring may improve the postoperative outcomes and reduce the unplanned postoperative readmissions.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients aged more than 18 years old. Patients scheduled for elective curative colorectal resection, including right (or extended) colectomy, left colectomy, rectal resection (with or without ileostomy), total colectomy, recanalization, or multiple colon resection. Patients willing to comply with the study procedures. Proficient understanding of the Italian language  Exclusion Criteria:  Any condition that, in the opinion of the investigator, may interfere with the study procedures. Patients scheduled for palliative surgery. Patients with a planned elective intervention requiring urgent or emergent surgery will be withdrawn from the study. Pregnant or breastfeeding women. Inability to comply with the study procedures. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Phenotypisation of Sleep Pattern in Hypertensive Patients With Non Dipper Pattern
Status: Recruiting

High blood pressure is the most common modifiable risk factor for cardiovascular diseases (CV). The large interindividual variability in clinical expression of the disease and response to treatment, however, makes the management of the hypertensive patient complex.Therefore, identifying phenotypes of hypertensive patients associated with a specific CV outcome or who tend to respond/not respond to treatment is of paramount importance for improving CV prevention.

It has been shown that the phenotype of hypertensive patient with poor control of nighttime blood pressure values, especially when associated with a "non-dipper" profile, was associated with an increased risk of developing CV and cerebrovascular complications.

The non-dipper profile and nocturnal hypertension are caused by several factors including excessive salt intake and dysautonomia. However, they are also inevitably influenced by sleep duration and the presence of sleep disorders: obstructive sleep apnea (OSA), but also insomnia and periodic movements of the lower limbs,such as those frequently seen in restless legs syndrome, are among the the main determinants related to altered nighttime pressure pattern. However, such disturbances are not systematically assessed during the performance of monitoring 24h pressor and their impact in the outcome of the hypertensive patient is unknown.

The primary objective of this study is to phenotype non-dipper patients with or without nocturnal hypertension to determine the prevalence of sleep disorders such as sleep apnea syndrome, insomnia, and restless legs syndrome (RLS) (OSA diagnosed considering AHI>5 events/hour, insomnia and RLS according to ICSD 3 criteria) and correlate the presence of various sleep disorders with cardiac organ damage, vascular, and renal damage mediated by hypertension.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  >18 years old; arterial hypertension defined as: a) office systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg AND either 24-hour ambulatory systolic BP ≥130 mmHg and/or diastolic BP ≥80 mmHg OR b) the presence of antihypertensive treatment; non-dipper pattern at 24-hour BP monitoring (confirmed on repeated ABPM including one performed within 3 months prior to enrolment and one after enrolment, both on the same antihypertensive treatment, if any), defined as a nocturnal decrease systolic and/or in diastolic BP values <10% compared to the corresponding daytime values; signed written informed consent;  Exclusion Criteria:  shift workers atrial fibrillation/flutter; pregnancy and lactation; terminal malignant disease, life expectancy <6 months; limb amputation; dementia. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Patients with non-dipper status with or without nocturnal hypertension - SamplingMethod: Non-Probability Sample
RCT of Traditional Islamically Integrated Psychotherapy (TIIP) for Muslims With OCD in Pakistan
Status: Not yet recruiting

The current study aims to determine the effectiveness of the first culturally adapted Traditional Islamically Integrated Psychotherapy (TIIP) for Muslims with OCD in Pakistan along with the module effectiveness in reducing OCD symptoms with comorbidities like anxiety, depression, stress, thought control, thought-action fusion, and enhancing the spiritual quality of life of participants.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  The client diagnosed with OCD according to DSM-5-TR; ii) The minimum score on Y-BOCS is 08 (i.e., indicating moderate level of symptoms), iii) the age range is from 18 to 40 years iv) the client has a minimum of eight years of formal education.  Exclusion Criteria:  The client is having a comorbid diagnosis of severe psychiatric illness (e.g., psychotic disorders, personality disorder, substance use disorder, neurocognitive disorder), ii) the client is having a comorbidity of chronic physical illness, iii) the client refused to sign the informed consent form, and iv) the client has experience undergoing manualized faith-based CBT. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 40 Years - StdAgeList: Adult
Detecting Minimal Residual Diseases (MRD) and Monitoring Clonal Evolution Using Ultrasensitive Chromosomal Aberrations Detection (UCAD) in Multiple Myeloma
Status: Recruiting

The presence of minimal residual disease (MRD) is an important prognostic factor for multiple myeloma, while copy number variation (CNV) is a widely accepted biomarker used for multiple myeloma (MM). Detecting MRD and monitoring clonal evolution by monitoring CNV using low-pass whole genome sequencing is promising due to its high analytical sensitivity. To evaluate the correlation between MRD detected by flow cytometry and low-pass whole genome sequencing, nearly 200 samples were collected for this study. We applied ultrasensitive chromosomal aberrations detection to detect CNV for each patient. The follow-up samples were then collected and sequencing used the same method.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Subjects diagnosed with MM. With available baseline and sequential next-generation flow-MRD data.  Exclusion Criteria:  Subjects without baseline and sequential next-generation flow-MRD data. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Multiple myeloma patients with baseline and sequential next-generation flow-MRD data are included in this study. - SamplingMethod: Probability Sample
engAGE: Managing cognitivE decliNe throuGh Theatre Therapy, Artificial Intelligence and Social Robots drivEn Interventions
Status: Recruiting

The objectives of the engAGE project are to counteract and slow down cognitive decline progression, to enhance the intrinsic capacity of the users, and to support the wellbeing of older persons with mild cognitive impairment (MCI) by providing an ecosystem of services based on an innovative system that integrates social robots.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  mild cognitive impairment (MCI); Montreal Cognitive Assessment (MoCA) score 21 - 25; Memory Assessment Clinics - Questionnaire (MAC-Q) ≥ 25; Reisberg scale 2 - 4; Clinical Frailty Scale score 1 - 3; 4-items GDS score ≤ 1; have an informal caregiver to support in carrying out the main daily activities.  Exclusion Criteria:  lack of informal caregivers; significant visual or hearing impairment. - HealthyVolunteers: No - Gender: All - MinimumAge: 65 Years - StdAgeList: Older Adult