rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
Comparison Between Drinking Water and Normal Saline in Irrigating Traumatic Wound
Status: Not yet recruiting

There is a controversy regarding the roles of the Normal saline and Tap water in irrigation of the wound. It has been suggested that antiseptic solution including normal saline has cytotoxic effect while tap water damages the fibroblast. There are no high level evidence to support one type of solution over other, systematic review have found no difference in wound infection between irrigation with normal saline vs tap water. There are ten randomized controlled trial comparing tap water with normal saline for irrigating wound published between 1992 to 2016. These RCT are analyzed in three systemic review and meta-analysis published on 2016, 2019, 2022, which showed that tap water and normal saline has no difference in terms of infection rate. The infection rate observed in various studies ranges from 0-11.5% in normal saline group and 0-12.6% in tap water group with no statistically significant difference.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Laceration wound presenting within 6 hours of duration Lacerations involving upper and lower limbs, scalps, head and neck  Exclusion Criteria:  Lacerations involving, lips, ears, mucosal surface, perineal and peri anal region Punctured or penetrating wound Bite wounds by human or animals or snakes Dirty wound requiring surgical debridement Patient requiring irrigation of wound with more than 1 liter of fluid Wounds involving tendon, joint or bone Wound associated with open fracture Patient on corticosteroid, antibiotics or immunosuppressant Patient who are not able to come for follow-up Immunocompromised patient Patient with history of significant peripheral vascular disease - HealthyVolunteers: No - Gender: All - StdAgeList: Child, Adult, Older Adult
Effect of Different Modalities of Cryotherapy on Post-Operative Pain in Patients With Symptomatic Irreversible Pulpitis
Status: Not yet recruiting

Problem statement: The post-operative pain after endodontic treatment. aim of study: The study is aiming to compare postoperative pain after submucosal cold saline injection (submucosal cryotherapy) (SMC) versus intra-canal cryotherapy (ICC) in mandibular single rooted premolars with symptomatic irreversible pulpitis with symptomatic apical periodontitis (SAP). The material and methods: Subjects and methods: sixty patients will be randomly divided into three groups: the SMC group, the ICC group, and the control group. The patients' postoperative pain will be recorded at 12, 24, and 48 hours postoperatively by questioning them. Quantification of substance P will be done using an ELISA test from peri-radicular fluid swab.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Older than age of 18 years Participants willing to commit for the entire period of the trial and Both genders agreed to sign the written consent after full explanation of the study Having a mandibular single rooted premolar tooth with vital pulp These patients were also suffering from symptoms of symptomatic irreversible pulpitis and apical periodontitis, intermittent or continuous sharp pain that lasts longer after removal of the stimulus. on the basis of the clinical symptoms of severe preoperative pain (visual analogue scale)  Exclusion Criteria:  Vulnerable group; prisoners, pregnant females, mentally ill, etc… Teeth with open apices A previous root canal treatment Sinus tracts Presence of periodontal pockets >3 mm in the affected tooth - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
The Protein Disrupted in Schizophrenia 1 (DISC1) as a Novel Biomarker for Cardiac Disease
Status: Recruiting

To study the association between DISC1 RNA expression levels and cardiac function in patients with schizophrenia.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients with ICD-10 schizophrenia, schizotypal or delusional disorders (F20 to F29) Both inpatient and outpatient Capable of giving informed consent  Exclusion Criteria:  Current or previous diagnosis of cancer Current or previous treatment with chemotherapy Current pregnancy Mothers less than 6 months post-partum - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult - StudyPopulation: The cohort with schizophrenia will be recruited from outpatient and inpatient population from a single centre.  The cohort without mental health diagnosis will be selected from an existing population registered in the HUNT data and biobank and be matched for age (± 2 years) and sex of the patients. - SamplingMethod: Non-Probability Sample
Comparison of Two PPOS Models for Pituitary Suppression
Status: Not yet recruiting

The scarcity of evidence regarding the interchangeable use of different progestogens poses challenges, particularly in international egg donation and fertility preservation programs where standardizing protocols is crucial for achieving consistent efficacy, efficiency, and safety outcomes. Consequently, there's a pressing need for clinical studies to assess the effects of various progestogens on clinical outcomes in controlled ovarian hyperstimulation cycles. This study, a pioneering effort, aims to compare the effects of two progestogens on oocyte performance, safety, and efficiency in an egg donation program involving young, healthy, normo-responding patients.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  BMI of 18-29,9 kg/m2 Ultrasound count of antral follicles prior to COH ≥ 12 follicles Meeting the criteria for inclusion in the egg donation program Normal karyotype and no active sexually transmitted diseases No use of combined hormonal contraceptives one month before COH  Exclusion Criteria:  Patients excluded from the egg donation program Untreated sexually transmitted diseases, positive serology for HBV, HIV, HCV Blood disorders, neurodegenerative/psychiatric diseases, carriers of X-linked genetic diseases, oncological diseases, endometriosis. Oligomenorrhea (<1 menstrual cycle in 3 months) Use of combined hormonal contraceptives before COH - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - MinimumAge: 18 Years - MaximumAge: 34 Years - StdAgeList: Adult
Telehealth and Onsite Maintenance Exercise in COPD
Status: Recruiting

The goal of this pilot clinical trial is to compare telehealth and onsite supervised maintenance exercise program for adults with COPD.

The specific aims of the study are:

To compare 8-week supervised maintenance program delivered onsite and via tele-rehab with no maintenance for patients with COPD following discharge from traditional exercise or physical therapy or onsite outpatient rehabilitation programs on clinical outcomes (dyspnea, exercise capacity, physical function, physical activity, and quality of life) at 8 weeks and 4-months post-intervention.
To compare the differences in dyspnea, exercise capacity, physical function, physical activity, and quality of life between an 8-week maintenance program delivered onsite and via tele-rehab at 8-weeks and 4-months post-intervention in patients with COPD following discharge from traditional onsite outpatient rehabilitation.

Participants in both intervention groups (onsite and tele-rehab) will undergo a baseline onsite assessment followed by an 8-week supervised exercise intervention either onsite or in a telehealth setting. Control group will receive biweekly check in calls, but no active intervention.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  All adult patients 40 years and older with physician diagnosed COPD within 2 months of discharge following completion of a traditional onsite outpatient rehabilitation or physical therapy or exercise program for their condition Meeting the COPD criteria of postbronchodilator forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) ratio of less than 0.70 Able to walk independently with or without mobility devices Able to complete a six-minute walk test at discharge with or without supplemental oxygen maintaining an oxygen saturation at or above 85% Able to follow commands and instructions in the English language Have ability to connect to the internet  Exclusion Criteria:  • Those with significant mobility limitations such as those with a history of stroke, neurological comorbidities such as Parkinson's disease or relapsing multiple sclerosis, or significant degenerative osteoarthritis, or any other joint impairments that compromise ability to walk independently with or without an assistive device.  Patients who primarily rely on a wheelchair for mobility Patients with or without supplemental oxygen who are unable to complete a walking test without a drop in oxygen saturation to below 85% at discharge from traditional outpatient rehabilitation Patients with baseline hemodynamic compromise, unstable angina, a recent myocardial infarction within a week, uncontrollable atrial fibrillation not managed with medications, advanced stage heart failure (New York Heart Association class 4), or those with mechanical circulatory assist devices for the heart such a ventricular assist device (VADs) Inability to communicate in the English language - HealthyVolunteers: No - Gender: All - MinimumAge: 40 Years - StdAgeList: Adult, Older Adult
Molecular Characterizazion and Biological Samples Centralisation of Patients Affected by Oncoematolofic Pathology
Status: Recruiting

Currently, the molecular characterization of onco-hematological, onco-immunological and hematological diseases, at onset or in relapse, of patients with suspected diagnosis afferent to the CROP centers, is done through centralization of biological samples at reference laboratories outside the Tuscany Region.

In order to preserve the wealth of clinical and biological data and use it for the benefit of present and future patients treated at the CROP centers, it is useful to evaluate the feasibility of centralization and molecular typing of mutations present in tumor tissue at the IRCCS AOU Meyer Oncohematology Laboratories and subsequently the analysis of clinical data from patients with diseases not under study to lay the foundations of a translational database that can then be associated with a biobank in the future.

This will enable a targeted contribution to pediatric oncohematology research, investing in possible targeted therapies with those patient subgroups that benefit from personalized disease assessment in mind. The goal of the project is to improve the regional infrastructure dedicated to organized data collection and management of biological samples in adequate time resulting in better and more comprehensive data collection.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Diagnostic suspicion of oncologic, hematologic or onco-immunologic disease Suspected recurrence of oncological, onco-hematological, hematological or onco -immunological disease Availability of biological material Signature of informed consent Age between 0 and 30 years  Exclusion Criteria:  Failure to sign the consent Insufficiency of biological material for analysis Patients with HIV, HCV and HBV seropositivity (HBSAg) due to biohazard and bias related to patients' immunological status that could influence gene expression and tumor behavior. - HealthyVolunteers: No - Gender: All - MinimumAge: 0 Years - MaximumAge: 30 Years - StdAgeList: Child, Adult
Effect of Paracetamol and Mannitol Injection on Postoperative Analgesia in Patients With Thoracoscopic Lobectomy
Status: Not yet recruiting

This study thoroughly evaluates the efficacy of acetaminophen mannitol injection for postoperative analgesia in patients undergoing thoracoscopic lobectomy, by comparing it with a control group.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Obtain informed consent； Patients scheduled for partial lobectomy under thoracoscopy with general anesthesia； Classified as American Society of Anesthesiologists (ASA) physical status I~II； Age over 18 years； Patients voluntarily participate and sign the informed consent form  Exclusion Criteria:  Systolic blood pressure ≥180 mm Hg or <90 mm Hg, diastolic blood pressure ≥110 mm Hg or <60 mmHg heart rate <50 beats/min； Patients with severe liver or kidney dysfunction (severe liver dysfunction: ALT, conjugated bilirubin, AST, ALP, total bilirubin any one >2 times the upper limit of normal severe kidney dysfunction: creatinine clearance <60 ml/min)； Patients with diabetes and complications (diabetic ketoacidosis, hyperosmolar coma, various infections, major vascular changes, diabetic nephropathy, retinopathy, diabetic cardiomyopathy, diabetic neuropathy, diabetic foot, etc.)； Patients with severe pulmonary impairment, such as asthma or chronic obstructive pulmonary disease； History of psychiatric illness or long-term use of psychiatric drugs, chronic pain medication, or history of alcohol abuse； Neuromuscular diseases； Tendency towards malignant hyperthermia； Allergy to the study drug or other contraindications； Participation in another drug clinical trial within the past 30 days； Any cerebrovascular accidents such as stroke, transient ischemic attack (TIA) in the last 3 months； Unstable angina, myocardial infarction in the last 3 months； Undergone another surgery within the last 3 months； Coagulopathy - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 60 Years - StdAgeList: Adult
Effect of Lidocaine Block on Gastroesophageal Reflux Disease
Status: Not yet recruiting

The goal of this clinical trial is to explore Clinical Effect of Stellate Ganglion Block on Gastroesophageal Reflux Disease. The main question it aims to answer is:

• Can stellate ganglion block improve gastroesophageal reflux symptoms better on the basis of rehabilitation training? Participants will be randomly allocated into the control group or the experimental group, all under rehabilitation treatment, the experimental group will be given Stellate Ganglion Block once a day additionally. The study lasts 10 days for each participant. Researchers will compare the Gastroesophageal Reflux Disease Questionnaire, Pressure pain threshold, Self-Evaluation Questionnaire for Gastroesophageal Reflux Disease, to see if the Stellate Ganglion Block can help improve the symptom.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Gastroesophageal Reflux Disease diagnosis aged between 18 and 80 years old. subjects who tolerate cervical movements in sitting position. stable vital signs. normal consciousness  Exclusion Criteria:  contraindications for stellate ganglion block. peptic ulcer. previous or present gastric cancer. previous gastric surgery. recent fractures or cervical trauma. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult
Diagnostic Performance of Plasma Biomarkers of Alzheimer's Disease Compared With CSF Markers
Status: Not yet recruiting

.The goal of this interventional study is to estimate the diagnostic performance of plasma biomarkers of interest (Aβ40 and Aβ42, P-Tau and NFL), enabling discrimination between patients with and without a pathophysiological AD process. The main questions it aims to answer are:

to define a threshold value for each of the plasma,
to describe the correlations between the plasma biomarkers of interest and the other biological analyses performed as part of care, in particular triglyceridemia, cholesterolemia, glycemia and proteinemia,
to describe biomarker results in relation to comorbidities, in particular dyslipidemia and diabetes
to describe the final diagnosis and results obtained for plasma biomarkers, for patients with intermediate results according to the A/T/N classification (A-/T+ or A+/T-) Participants will be selected among patients undergoing lumbar puncture for the differential diagnosis of AD at Nancy University Hospital.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Man or woman aged 18 or over Person affiliated to a social security scheme or beneficiary of such a scheme Person who has received full information on the organization of the research and has signed an informed consent form Person whose care requires a lumbar puncture to measure markers of Alzheimer's disease  Exclusion Criteria:  Adult subject to a legal protection measure (guardianship, curatorship, safeguard of justice) An adult unable to give consent Persons deprived of their liberty by judicial or administrative decision Persons under psychiatric care under articles L. 3212-1 and L. 3213-1. Pregnant, parturient or breast-feeding women Persons staying in a health or social establishment for purposes other than research. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Effect of Lidocaine Block in Traumatic Brain Injury
Status: Not yet recruiting

The goal of this or clinical trial is to explore efficacy of stellate ganglion block on dysphagia and activities of daily living in Traumatic Brain Injury Patients. The main question it aims to answer are:

Can stellate ganglion block improve the dysphagia and activities of daily living in Traumatic Brain Injury Patients.

Traumatic Brain Injury Patients will be divided into the the control group and observation group evenly. All the patients were provided with routine therapy, while the patients in the observation group were given stellate ganglion block. The swallowing function, and activities of daily living of the two groups of patients before and after treatment were evaluated.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  age ≥ 18 years, meeting the diagnosis of Traumatic Brain Injury; presence of no contraindication for Stellate Ganglion Block; with stable vital signs and no severe liver or kidney dysfunction, metabolic disorders. informed consent form was obtained from the patient's family members, indicating their full - understanding of the study and agreement to participate.  Exclusion Criteria:  unable to cooperate in completing treatment and assessment due to personal reasons or other disorders; complicated with other intracranial lesions, such as stroke; with severe consciousness disorders caused by other diseases. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Efficacy of Lidocaine Block in Children With Cerebral Palsy and Dysphagia
Status: Not yet recruiting

The goal of this clinical trial is to test the efficacy of stellate ganglion block in children with cerebral palsy and dysphagia. The main question it aims to answer are:

• Can stellate ganglion block improve the dysphagia of children with cerebral palsy? Participants were randomly divided into two groups, all provided with routine therapy. Based on this, the experimental group was given stellate ganglion block. The video fluoroscopic swallowing study was done to test the swallowing function before and after the study.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  meeting the diagnostic criteria of cerebral palsy formulated by the 13th National Conference on Pediatric Cerebral Palsy Rehabilitation; age between 4 to 7 years; diagnosed as dysphagia confirmed by Dysphagia Disorder Survey or pediatric esophagoscopy;  Exclusion Criteria:  with dysphagia caused by other diseases or factors; progressive neurological disease or degenerative neurological disease; with severe heart disease, liver or kidney dysfunction, hematological disorders; with abnormalities in the oral cavity, pharynx, esophagus, or other parts of the digestive tract; with poor compliance. - HealthyVolunteers: No - Gender: All - MinimumAge: 4 Years - MaximumAge: 7 Years - StdAgeList: Child
Restorative Environments for Gait Therapy With VR
Status: Recruiting

The aim of our study is to investigate the effects of landscapes during gait therapy. The investigators will evaluate the impacts of restorative landscapes as they occur in urban, rural and forest environments. Older people will experience those landscapes using virtual reality (VR) goggles during their gait training. The investigators expect the landscapes to have an effect on the following three aspects: (1) stress reduction, (2) restoration of attention and (3) change in gait parameters. For this purpose, volunteers who are currently inpatient in one of our study centers and already participating in gait therapy will be assigned to a group. The control group will receive the standard therapy. The participants of the intervention groups will receive five additional VR training sessions to the standard therapy. In these sessions, the participants will walk through urban, rural and forest landscapes and perform balance improvement exercises. The five training sessions will take place within ten days. Allocation to the control or intervention groups and their landscapes is random. At the start and end of participation, tests defining stress levels and gait parameters are carried out so that comparisons can be made between before and after treatment. The goal of the study is to find out which type of landscape supports restoration and can therefore contribute to greater gait stability. The investigators expect that improved gait stability will be promoted by stress reduction and increased attention induced by the virtual environments. The investigators are investigating the consequences of repeated application of virtual landscapes and the relationship between the effect of the landscape and the preferences and habits of the study participants.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  age: > 65 years german-speaking ability to give informed consent attends gait safety training (usual care) inpatient for a duration of min. 2 weeks in one of the study sites items 7 - 15 of the De Morton Mobility Index (DEMMI): min. 2 points, max. 9 points 3-minute walking distance: > 30 m without rest, with or without walking aids, overground walking on flat surface  Exclusion Criteria:  epilepsy Partial weight bearing or conservatively or surgically treated billing with weight bearing as determined by symptoms Severe hearing impairment (if not corrected with hearing aid) Injuries to the eyes, face, or neck that prevent comfortable use of VR glasses. - HealthyVolunteers: No - Gender: All - MinimumAge: 65 Years - StdAgeList: Older Adult