rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
Effects of Modified Constraint-induced Movement Therapy With and Without Electrical Stimulation in Erb's Palsy
Status: Not yet recruiting

ERB's palsy is an injury of upper section of the brachial plexus (C5-6) leading to an internally rotated and adducted shoulder and a pronated forearm. Modified constraint-induced movement therapy improves the functionality of the affected limb, while electrical stimulation helps in the improvement of active range of motion and muscle strength in ERB's palsy patients. This study aims to investigate the effects of modified constraint-induced movement therapy with and without electrical stimulation on range of motion, muscle strength, and motor functions in patients with ERB's Palsy.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Children with a confirmed diagnosis of ERB's palsy. Muscle power of the affected limb should be between 1 to 4. Active finger range of motion,10-degree wrist extension, and thumb abduction.  Exclusion Criteria:  Children having contracture and stiffness of affected limb. Muscle power of affected limb 0 or 5. Children with cerebral palsy, visual, hearing, and cognitive problems, or any neuromuscular, and skeletal disorders. Previous history of neurological and orthopedic surgery - HealthyVolunteers: No - Gender: All - MinimumAge: 2 Years - MaximumAge: 6 Years - StdAgeList: Child
Revascularization for Symptomatic Non-acute Carotid Artery Occlusion
Status: Recruiting

The short-term and long-term efficacy of recanalization therapy needs to be further confirmed by large-sample prospective studies. The comparison of success rate, complication rate and efficacy among the three recanalization modalities also needs to be further explored. The purpose of this cohort study is to observe the success rate, efficacy and safety of recanalization treatment for non-acute occlusion, and to further compare the advantages and disadvantages of CEA, endovascular intervention and hybrid surgery.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Older than 18 years old; Sign the informed consent form; Carotid occlusion at least 24h; Patients with clinical localization symptoms: ipsilateral hemisphere ischemia symptoms or ipsilateral eye ischemia symptoms or cognition impairment, with or without anterior circulation blood supply area infarction; DSA confirmed common carotid artery or internal carotid artery (mTICI=0) occlusion; Perfusion imaging confirms the presence of hypoperfusion in the corresponding area(CBF decrease); The optimal medical treatment for patients who still have ischemic symptoms; Routine DWI and ADC sequence examinations are performed before surgery no new infarction;  Exclusion Criteria:  Intracranial arteriovenous malformation or aneurysm; Unstable angina, myocardial infarction (MI), or congestive heart failure in the last 6 months; Uncontrolled diabetes mellitus defined as glucose > 300 mg/dL (16.67 mmol/L); Patient is expected to have the ADP antagonist therapy interruption within 3 months after the procedure; Pregnant or in the perinatal period; Severe concomitant disease with poor prognosis (life expectancy < 3 years); Intolerance or allergies to any of the study medications, such as aspirin or clopidogrel; Allergy to iodine or radiographic contrast media; Concomitant vascular conditions precluding endovascular; Patients with large cerebral infarction within 2 weeks; History of ipsilateral vocal cord paralysis; Those with severe skin diseases who are expected to have difficulty healing the incision; Poor functional status before onset (mRS score 4-5 points). The area of infarction in the occluded vascular area exceeds half of the vascular supply area; Already have dementia or psychiatric illness and are unable to complete neurological and cognitive assessments. Any condition that in the surgeon's judgment suggests the patient an unsuitable surgical candidate. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult - StudyPopulation: People diagnosed with non-acute carotid occlusion, fulfilled the above eligible criteria in tertiary medical centers in China additionally will be enrolled consecutively. - SamplingMethod: Non-Probability Sample
Comparison of Thrust Manipulation of Sacroiliac Joint and Pelvic Stabilization Exercises in Post Partum Low Back Pain
Status: Recruiting

compare the effectiveness of SI joint thrust manipulation and pelvic stabilization exercises on Modified OSWESTRY Low Back pain Index (ODI) and Numeric Pain Rating Scale (NPRS) in patients with post-partum lower back pain.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  age 20-40 years Postpartum women (after 6 weeks)(3, 12) Postpartum LBP patient Patient pain increased by provocation test i.e. Faber test, High thrust test and Gaenslen test  Exclusion Criteria:  C-section inflammatory or malignant type of pain Neurological deficit Severe trauma Pelvic fracture Osteoporosis, spinal stenosis, spondylolysis, spondoloesthesisi - HealthyVolunteers: No - Gender: Female - MinimumAge: 20 Years - MaximumAge: 40 Years - StdAgeList: Adult
Effects of Bruegger's Exercises Versus Egoscue Exercise on Lower Cross Syndrome
Status: Recruiting

This study aims to find effects of Bruegger's Exercise versus Egoscue exercise on pain and hyperlordosis on patient with lower cross syndrome. This is interventional study which recruits 34 participants ,14 in each group.

Eligibility:
- EligibilityCriteria: Inclusion Criteria: • Females and males aged between 16 to 65 years  Participants had to present with low back pain Participants had to meet the criteria for lower crossed syndrome indicating tight hip flexors (Modified Thomas test) and erector spinae (visual assessment through toe touching) together with weak glutei (Prone Hip Extension Co-ordination/Strength Test) and abdominals (Trunk Flexion Co-ordination and Strength Test)and thoracic kyphosis. Angle of anterior pelvic tilt > 10 degrees  Exclusion Criteria: • Participants who would be undergoing other forms of treatment that may interfere with the study, for the duration of the study, including other manipulative and physical therapies specific to back pain.  Presence of other conditions that may mimic low back pain, e.g. nerve entrapment. Participants taking any medication that may interfere with the results of this study including, pain medication, anti-inflammatory medication, and muscle relaxants. Surgery on the back, pelvis, or sacrum is indicated or has previously occurred LBP having localised or radiating pain. Practiced any kind of exercise or sports activity during the last 6 months. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 16 Years - MaximumAge: 65 Years - StdAgeList: Child, Adult, Older Adult
Effect of Kinesio Taping on Pain, Posture and Function in Lower Cross Syndrome
Status: Recruiting

Determine the impact of Kinesio taping on pain, postural alignment and functional outcomes in individuals with lower cross syndrome.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age- 30 to 50 years. Female patients. Anterior pelvic tilting > 7-10 degrees. Postural imbalance characterized by anterior pelvic tilt, lumbar hyper lordosis, and associated muscle imbalances. Discomfort, pain, or limitations related to the lower back, pelvis, and hips attributed to LCS. Willing to provide informed consent to participate in the study.  Exclusion Criteria:  Musculoskeletal pathologies affecting the lower back, pelvis, hips, or lower extremities (e.g., herniated disc, lumbar radiculopathy, lumbar stenosis, hip labral tear). Kinesiotaping interventions for LCS in the past 3 months. Allergies to tape materials or skin sensitivities that might prevent safe tape application. Pregnant individuals due to potential discomfort. Open wounds, infections, or skin conditions at the taping application site. Severe cardiovascular, pulmonary, renal, or neurological diseases. In other clinical trials involving interventions for LCS. - HealthyVolunteers: No - Gender: Female - MinimumAge: 30 Years - MaximumAge: 50 Years - StdAgeList: Adult
Predictive Model for the Occurrence of Cerebral Vasospasm Complicating Subarachnoid Haemorrhage by Combined Analysis of the Kinetics of a Panel of Biomarkers.
Status: Not yet recruiting

The objective is to create a dynamic clinical prediction model that includes routinely measured care and biological biomarkers to predict cerebral vasospasm within 14 days of bleeding in patients treated in the neurosurgical intensive care unit for subarachnoid hemorrhage.

Patients admitted to intensive care will be followed for up to 14 days (D14 time horizon of interest), or until discharge from intensive care if earlier.

Blood samples will be taken from D1 to D10 to isolate the blood biomarkers of interest for each patient.

The measurement of biomarkers and cerebral vasospasm will be blinded to each other.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Subarachnoid hemorrhage (of aneurysmal or non-aneurysmal etiology) less than 4 days prior to admission to neuro-resuscitation, diagnosed on clinical presentation and confirmed by brain imaging. Free, informed and written consent signed by the patient (or, failing this, his or her representative). Patient entitled to or affiliated with social security  Exclusion Criteria:  Significant vasospasm on admission to the department, diagnosed on initial imaging Patient whose short-term survival (48 hours) appears compromised Contraindication to perfusion CT scan Pregnant or breast-feeding women Patient under legal protection (persons deprived of liberty or under guardianship) - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Effects OF NMES With and Without Dynamic Bracing on Spasticity and Movement Quality in CP
Status: Recruiting

The study aims at comparing Neuromuscular electrical Stimulation with and without dynamic bracing on spasticity and movement quality of lower limb in Children with Cerebral Palsy

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age between 5 to 12 years. Able to walk with or without an assistive device. Classification as level I-II on the Gross Motor Functional Classification System (GMFCS). Able to stand with or without support for 1 minute. Classification as levels I-III on the Manual Ability Classification System (MACS); and the ability to follow and accept verbal instructions. Muscle tone scored ≥2, according to Modified Ashworth Scale.  Exclusion Criteria:  Orthopedic Surgical intervention (e.g. tendon lengthening in lower limb) within the previous 12 months Treatment with botulinum toxin in the calf muscles within the previous 6 months Presence of structural deformities at the lower limbs and trunk, or instability in the ankle joint, which could compromise the child's safety and performance of the motor task Severe affective or psychiatric impairments; Serious vision or hearing problems Any neurological impairment (epilepsy or any other disease that would interfere with physical activity) - HealthyVolunteers: No - Gender: All - MinimumAge: 5 Years - MaximumAge: 12 Years - StdAgeList: Child
Comparative Effectiveness of Qigong Exercise Versus Wu Dang Tai Chi Chuan in CVD Risk Individuals
Status: Not yet recruiting

To compare whether the Qigong exercise or Wu Dang Tai Chi Chuan will be effective in improving exercise capacity and reducing stress in CVD-risk individuals. Based on preliminary data, Qigong and Tai-Chi may help treat anxiety and depression symptoms in patients with chronic illnesses as well as in healthy adults. Without the need for specialized equipment, Qigong and Tai-Chi are both readily adjustable mind-body exercises that may be done whenever and wherever. For this reason, Qigong and TaiChi should be extensively encouraged as ways to enhance emotional wellbeing

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  According to the Framingham risk calculator 10% to 20%+ for moderate to high-risk Patients at risk of CVD (last 6 months) Patients with either HTN, dyslipidemia, or diabetes Patients with less than 45 scores on the Berg Balance scale Stress from moderate to severe on PSS No regular physical exercise for at least 1 year Willing to take part  Exclusion Criteria:  History of stroke, CVD Acute Infection Acute injury Any diagnosed psychological issue MSK disorders Member of marital arts, dance - HealthyVolunteers: No - Gender: All - MinimumAge: 30 Years - MaximumAge: 50 Years - StdAgeList: Adult
Comparative Effects Of Gaze Stability Exercises And Optokinetic Exercises In Patients With Vestibular Hypofunction
Status: Recruiting

This randomized clinical trial will occur at Bahawal Victoria Hospital, Bahawalpur within 7 months after the approval of synopsis. The sample size for this trial will be 40 participants. Participants fulfilling the inclusion criteria will be recruited by using the convenience sampling randomly allocated into two groups by computer generator method. 20 participants will be assigned to Group A receiving gaze stability exercises and 20 to the Group B receiving optokinetic exercises, both alongside routine physical therapy. Each group will undergo 5 weekly sessions of treatment for 4 weeks.The assessment tools include Dizziness Handicap Inventory for dizziness; Mini-BESTest and modified-Clinical Test of Sensory Interaction of Balance for balance assessment while Vestibular Disorders Activities of Daily Living Scale for daily activities.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Participants will be of both genders. Participants age will be between 23 to 63 years. Participants diagnosed with unilateral vestibular disorders by ENT specialist. Individuals who have MOCA score ≤26. Participants with positive head thrust test. Participants with positive supine roll test.  Participants have one or more of the following characteristics:  Related burden symptoms that affected their daily activities. A history of dizziness/vertigo triggered by head or body movement.  Exclusion Criteria:  Individuals with a history of neurological or psychological deficit. Individuals with the diagnosis of benign paroxysmal positional vertigo as individuals.  Individuals who had a previous surgery that could affect balance or cause dizziness.  Individuals with orthopedic problems that prohibited the performance of the exercise and that impact one's balance and walking pattern.  Individuals who report spontaneous episodes of dizziness, which are not worsened by movements Individuals which are completely dependent on the assistive device during mobility.  Imbalance due to diabetic neuropathy.  - - HealthyVolunteers: No - Gender: All - MinimumAge: 20 Years - MaximumAge: 60 Years - StdAgeList: Adult
Effects of Reflexology and Generalized Stretching in Postmenopausal Females.
Status: Recruiting

To determine the combined Effects of reflexology and generalized stretching on insomnia, vasomotor symptoms and quality of life in postmenopausal females

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  BMI less than 30 kg/m2 Residents of rural areas Stable vital signs Participants with natural cessation of menstrual periods for at least 12 months Moderate and severe hot flash  Exclusion Criteria:  Participants with history of hysterectomy surgical menopause females Participants with orthopedic disorder Participants taking sleeping pills Women suffer from pathological conditions for example cardiac disease, cancer impaired skin integrity Participants with history of recent bone fracture Severe pathology(eczema) of feet - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - GenderBased: Yes - GenderDescription: post partum females - MinimumAge: 50 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult
Post-surgical Outcomes With Anabolic Agent Use in High-risk Ankle Fractures: A Pilot RCT
Status: Not yet recruiting

As the global population ages and the prevalence of poor bone health increases among older patients with ankle fractures, so does the risk of post-surgical complications. Prevention of post-surgical complications is of paramount importance to reducing morbidity, mortality, and healthcare costs.

There is growing evidence to support the use of bone-building medications, such as Teriparatide, in patients who have delayed fracture healing or non-unions; however, these medications have yet to be investigated in elderly patients with ankle fractures at high risk for delayed fracture healing and post-operative complications. This project aims to assess the safety and efficacy of short-term Teriparatide use in improving outcomes in a population most likely to suffer post-operative complications.

The proposed study is a pilot randomized controlled trial (RCT) with patients 60 years or older with an additional risk factor for delayed healing (i.e., osteoporosis, diabetes, vascular disease) who require ankle fracture surgery. Participants will be randomized to receive the study medication (Teriparatide) or placebo for three months. The primary objective of this study is to acquire vital data (i.e., recruitment rates, follow-up rates, adherence to treatment assignment) required to determine the feasibility of a full-scale multi-centre RCT. Additional aims are to evaluate repeat surgery, complications, time-to-union, and 90-day mortality. A complete a socio-economic and feasibility analysis will be completed.

This study will evaluate the novel clinical approach of augmenting surgical fixation with a medication to build bone density and strength, thereby improving bone health, preventing complications, and improving outcomes. This study will also inform planning for a larger clinical trial to reduce the morbidity, mortality, and cost associated with complications in this high-risk population.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Our study will include men and women over 60 years of age presenting to the emergency department with low energy ankle fractures (fall from standing height) requiring surgical treatment and who have one or more of the following risk factors, diabetes, osteoporosis, renal disease, steroid use, smoking history, peripheral neuropathy and/or vascular disease.  Exclusion Criteria:  Individuals will be excluded if they have received previous Teriparatide therapy, or they have hypercalcemia or hyperparathyroidism, as these are precautions to the use of Teriparatide. - HealthyVolunteers: No - Gender: All - MinimumAge: 60 Years - StdAgeList: Adult, Older Adult
Transcutaneous Auricular Vagus Nerve Stimulation on Dizziness & Balance in Elderly Population
Status: Recruiting

The objective of the study is to determine the effects of transcutaneous auricular vagus nerve stimulation on dizziness and balance on elderly population with unilateral vestibular hypofunction. Patients will be divided into experimental and control group. Randomized participants will be allocated into control and experimental group. Intervention Group A received Vagus Nerve Stimulation (VNS) and Caw Thorne Cooksey exercise while Group group B received Caw Thorne Cooksey exercise only. Both groups received intervention of 30 minutes daily for 4 weeks (16 sessions). Assessment was done at the baseline, after 2 weeks and after 4 weeks

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Able to give consent Age 60 and above Diagnosed patient of unilateral(Left) vestibular hypo function Both Genders BBS with 20-41  Exclusion Criteria:  Patient with any neurological impairment (Epilepsy, stroke ALS etc.) Central cause of vestibular hypo function History of vestibular neuritis, concussion, head injury or tumor. - HealthyVolunteers: No - Gender: All - MinimumAge: 60 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult
Generalized Versus Core Stabilization Antenatal Exercises For Lumbopelvic Pain
Status: Recruiting

Core stability training has gained popularity as a fitness trend and is now being used in rehabilitation programs as well the patient adherence to this intervention has been low due to its complex nature, particularly pregnant females .Limited literature is available to present the effect of core stabilization exercises in comparison to the other handful simplified techniques and exercises This study compares two interventions for this particular condition to identify a feasible and enjoyable therapeutic intervention for the pregnant women who suffer Lumbopelvic Pain.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  2nd Trimester of Pregnancy Multigravida Patients having Lumbopelvic pain Working women and housewives  Exclusion Criteria:  Hx of Metabolic Disease Hx of Pelvic Fracture and Surgery Radiculopathy Participants with absolute contraindications for the exercise - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - GenderBased: Yes - GenderDescription: Female - MinimumAge: 18 Years - MaximumAge: 30 Years - StdAgeList: Adult
Effects of Abdominal Binders and TENS on Puerperium Period After Cesarean Section
Status: Recruiting

To determine the combined effects of abdominal binders and TENS on post-operative pain, distress and constipation in puerperium period after cesarean section

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Participants on early puerperium period having constipation and willing to participate. Primigravida Body mass index (BMI) less than 30 kg/m2  Exclusion Criteria:  Laxatives-induced patients History of chronic constipation Post cesarean abdominal suture infection. People with chronic diseases, and who underwent non-routine or additional surgical procedures, such as hysterectomy, tubal ligation, and classical uterine incision. Participants with inability to tolerate the binder. Participants who show unwillingness to participate in the study - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - GenderBased: Yes - GenderDescription: PUERPERIUM PERIOD AFTER CESAREAN SECTION - MinimumAge: 18 Years - MaximumAge: 35 Years - StdAgeList: Adult
Effects of Manual Lymphatic Drainage and Therapeutic Ultrasound on Breast Engorgement
Status: Recruiting

To find the combined effects of the manual lymphatic drainage with therapeutic ultrasound on breast engorgement, pain and self-efficacy in post - partum women.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Both primiparous or multiparous breastfeeding women BMI: ≤30-≥25 (14) Immediate puerperium with normal or C - section non-premature childbirth (19) Postnatal lactating mother with symptoms of breast engorgement  Exclusion Criteria:  any breast infection, abscess, mastitis, breast cancer torn/bleeding or crack nipples any skin condition like dermatitis, psoriasis etc non-lactating mothers having heart pacemaker - HealthyVolunteers: No - Gender: Female - GenderBased: Yes - GenderDescription: POST - PARTUM WOMEN - MinimumAge: 18 Years - MaximumAge: 35 Years - StdAgeList: Adult
Effects of Traditional Moderate Intensity Training and High Intensity Interval Training in Polycystic Ovarian Syndrome
Status: Recruiting

To determine the comparative effects of traditional moderate intensity training and high intensity interval training on Anxiety, fatigue and Quality of Life in females with polycystic ovarian syndrome

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Participants with BMI greater than 25kg/m2 Oligo- or anovulation/irregular cycles i.e 35 days Married women Primary infertility A diagnosis of polycystic ovaries based on ultrasound results  Exclusion Criteria:  Use of psychiatric or psychotropic medications. Unresolved gynecological conditions i.e Cervical Dysplasia, Pelvic floor prolapse, Uterine Fibroids, Urinary Incontinence Diabetes, pregnancy, smoking, illness or injury that prevented or limited exercise performance and existing participation in regular physical activity - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - GenderBased: Yes - GenderDescription: POLYCYSTIC OVARIAN SYNDROME - MinimumAge: 18 Years - MaximumAge: 35 Years - StdAgeList: Adult