rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
Evaluate the Efficacy and Safety of D-2570 in Participants With Moderate-to-Severe Plaque Psoriasis
Status: Recruiting

This is a randomized, double-blind, placebo-controlled, multicenter clinical trial in participants with moderate-to-severe plaque psoriasis .

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Subject voluntarily takes part in the study after being fully informed,signs a written ICF, and agrees to follow procedures specified in the study protocol; Plaque psoriasis assessed by the investigator as suitable for systemic treatment and stable (defined as stable as no significant outbreak of morphological change or disease activity assessed by the investigator) for at least 6 months prior to signing informed consent; During the screening period and before taking the investigational drug for the first time, psoriatic surface area (BSA) ≥10%, PGA score ≥ 3, PASI score ≥ 12; Hematology, Blood chemistry and Urinalysis examination were basically normal.  Exclusion Criteria:  Erythrodermic psoriasis, pustular psoriasis, guttate psoriasis, reverse psoriasis, drug-induced psoriasis; Have other skin lesions that affect the evaluation of treatment outcomes, such as eczema; History of herpes zoster/herpes simplex, or presence of herpes zoster/herpes simplex infection during the screening period; Have a history of tuberculosis, or active tuberculosis, or latent tuberculosis, or suspected clinical manifestations of tuberculosis infection; Other conditions that the investigator considers inappropriate for participation in the study. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 70 Years - StdAgeList: Adult, Older Adult
Correlation of Toxins With Gastrointestinal (GI) and Overall Health
Status: Not yet recruiting

The goal of this observational study is to evaluate the levels of urinary environmental toxins, heavy metals, PFAS and mycotoxins with gastrointestinal (GI) and overall health.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients suffering from gastrointestinal and/or other symptoms Patients willing to provide urine samples Patients willing to provide consent  Exclusion Criteria:  Use of antibiotics 2 weeks prior to the study Patients unwilling to consent - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: The patient group will include individuals presenting with digestive and/or non-digestive symptoms or conditions and whose medical evaluation includes 'toxin assessment,' as determined by the treating physician. - SamplingMethod: Non-Probability Sample
Effect of Agonist GLP1 on Adipose Tissue in Patients Undergoing Bariatric Surgery
Status: Not yet recruiting

Normalizing weight gain and preventing the redistribution of body fat is a major health issue, and could help prevent the onset of various symptoms of metabolic syndrome. Above all, it is important to understand the mechanisms by which these different treatments affect adipose tissue. To this end, the investigators will first study the impact of GLP-1 analogues on adipose tissue. The main objective is to show that subjects treated with a GLP-1 agonist have a significant change in their oxytocin levels compared with subjects not treated with a GLP-1 agonist.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patient over 18 years of age. Patient able to read and understand the information/consent leaflet. Patient with BMI > 35 with at least one comorbidity. Or BMI > 40 Indication for digestive surgery validated in a multidisciplinary consultation meeting and prior agreement accepted by the CPAM. Membership of a social security scheme Patient's signed informed consent For subjects in the GLP-1 analogue group: GLP-1 analogue taken for at least 3 months. For non-GLP-1 analogue group: never taken GLP-1 analogues.  Exclusion Criteria:  Pregnant or breast-feeding women. Vulnerable patients (under guardianship) Patients deprived of liberty - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Telerehabilitation Program Bases Aerobic and Baduanjin Exercises in Post Stroke Elderly Patients
Status: Recruiting

It is an interventional study in which 60 stroke patients estimated to enroll according to random allocation and will divided into two groups. The study group participants will involve in Telerehabilitation sessions will be based on low-impact rhythmic movements, guided by video with the Baduanjin exercise program ,the control group will receive the same aerobic exercises only

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  • The subject selection will be according to the following criteria:  All Patients of this study will be diagnosed as stroke and the diagnosis will be confirmed by computed tomography or MRI (El-Tamawy et al., 2021). Age of patients will be more than or equal 65years (males and females). All patients will be hemodynamically stable.  Exclusion Criteria:  • The potential participants will be excluded if they meet one of the following criteria:  Patients who cannot follow instructions as sensory aphasia, blindness, dementia, and deafness. Patients with any orthopedic, neurological, or chest disorders that affect trunk muscles control or cause respiratory disorders as COPD. Patients with psychiatric disorders. Patients with unstable cardiovascular conditions. uncontrolled hypertension, or other concomitant respiratory diseases participate at any research or rehabilitation program during the period of this study - HealthyVolunteers: No - Gender: All - MinimumAge: 65 Years - MaximumAge: 75 Years - StdAgeList: Older Adult
Bihemispheric Transcranial Direct Current Stimulation* on Speech Fluency
Status: Recruiting

It will be determined whether bihemispheric stimulation (anodal to the left IFG and cathodal to the right IFG) is used with fluency-facilitating conditions for 5 consecutive days in individuals with stuttering and whether there is a difference in terms of the effects seen in speech fluency compared to the sham condition.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  developmental stuttering age between 18 and 60 years right hand dominant  Exclusion Criteria:  history of seizures, head trauma, hearing problems, cochlear implant, intracranial metal implantation, medications that affects the central nervous system, implanted neurostimulators, cardiac pacemakers, or medication infusion devices any speech and language disorder other than developmental stuttering neurological or psychiatric disorders, brain surgery, tumours, neurodevelopmental disorders, or attention deficit hyperactivity disorder - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 60 Years - StdAgeList: Adult
Scheimpflug Versus Placido-disc System in Evaluation of Corneal Higher-Order Aberrations
Status: Not yet recruiting

Aim of work:

To assess the agreement between placido-based topographer (wavelight allegro topolyzer vario) and scheimpflug -based (Oculus Pentacam ) regard measuring corneal higher order aberrations before and after LASIK.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients with refractive errors from +6 diopters to -8 diopters sphere and up to -6diopters cylinder.  Exclusion Criteria:  Patients with systemic diseases such as diabetes. keratoconus or keratoconus suspect, amblyopic eyes. Patients with best corrected visual acuity (BCVA) not achieving 20/25. glucoma Previous ocular surgeries or trauma. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 45 Years - StdAgeList: Adult - StudyPopulation: Patients who will undergo LASIK - SamplingMethod: Non-Probability Sample
Masseter Muscle Thickness in Gasser Ganglion Radiofrequency Treatment
Status: Not yet recruiting

Trigeminal neuralgia is common painful disorder in pain medicine clinics. Gasserian ganglion radiofrequency thermocoagulation is one of the treatment option in patients with trigeminal neuralgia in refractory cases. The most commonly involved branch in trigeminal neuralgia is the mandibular branch. Masseter muscle is innervated by mandibulary nerve branch of the trigeminal nerve.

The radiofrequency thermocoagulation therapy is used to ablate the affected trigeminal nerve branch and some of patients complain of subjective masseter weakness after this procedure.

In theoretical basis, muscles innervated by target nerve are affected from ablation procedure. In this study the primary aim is to evaluate the change of the masseter muscle thickness in patients treated by gasserian ganglion radiofrequency thermocoagulation. The results may also show possible functional effect of the procedure related with masseter muscle.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Pain refractory to medical therapy for at least 3 months Planning radiofrequency thermocoagulation of gasserian ganglion Accept ultrasound measurements to be performed  Exclusion Criteria:  Refused to participate in the study Not attending follow-ups regularly Coagulation disorder Pregnancy Localized or systemic infection - HealthyVolunteers: No - Gender: All - MinimumAge: 40 Years - MaximumAge: 85 Years - StdAgeList: Adult, Older Adult
Diabetes, Metabolic Syndrome and Risk of Malaria in Cameroon
Status: Recruiting

Non-communicable diseases (NCDs) such as diabetes are increasing in countries where malaria transmission is common. This study aims to investigate the relationship between NCDs and parasitic infections in Cameroon. The investigators will assess the risk of malaria, as well as other parasitic diseases, in a prospectively followed group of adults with diabetes, compared with those without diabetes. Malaria parasites and intestinal worms will be tested using blood and stool collected at four time points during a one-year follow-up. In addition, this project will investigate how natural protection against malaria is affected by diabetes and other risk factors for heart diseases.

Eligibility:
- EligibilityCriteria: Inclusion Criteria: Age 21 years and above with diagnosis of type 2 diabetes -  Exclusion Criteria: pregnancy  - - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 21 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Adult patients with type 2 diabetes identified at the outpatient diabetes clinic of Limbe Regional Hospital will be invited to the study. Community comparators matched on age and sex will be identified in the patients' family or in the home community to control for exposure to similar malaria transmission. - SamplingMethod: Non-Probability Sample
Awareness Training in Children With Autism Spectrum Disorder.
Status: Recruiting

The proposed protocol aims to facilitate awareness and understanding of autism spectrum disorder among children aged 8 to 14 with an IQ between 85 and 115. Conducted once a week for 60 minutes, the protocol encompasses two initial group sessions followed by 5 group meetings, introducing activities to foster self-awareness, cognitive understanding, and an inclusive environment. Subsequently, the protocol advances to 12 individual sessions focused on emotional well-being and self-awareness, integrating Oculus technology and chest sensors for heart rate monitoring. Initiating the intervention, individual family meetings are scheduled to outline intervention goals and phases. The initial group sessions focus on social bonding, cognitive understanding, and creating an accepting atmosphere among participants. Utilizing activities addressing neurodiversity awareness and technological tools like tablets, the sessions encourage discussions on individual differences and sensitivities. The subsequent individual sessions are structured to explore personal values, identify inner critical voices, and develop emotional awareness through exercises exploring emotions and physical sensations. Progressively, the intervention introduces mindfulness, guiding participants to acknowledge emotions as normal and encouraging alignment of daily actions with personal values. Following this, sessions center on building observational skills, recognizing past behaviors, and fostering strengths tied to values. Participants are encouraged to distinguish between their critical "consultant" and the value-driven "explorer," fostering personal growth and reflection. The protocol's later stages delve into identifying personal strengths linked to core values and exploring value-driven goals. Visual exercises, metaphors, and flexible self-views are emphasized, promoting adaptability and self-evolution. The protocol concludes by advocating a flexible self-view, embracing change, and connecting oneself to ever-evolving metaphors like "a cup with changing contents" or "the ever-changing sky." These sessions culminate with visual relaxation facilitated through Oculus technology while simultaneously monitoring participants' heart rates using chest sensors. This comprehensive approach integrates technological tools with emotional and cognitive exercises, providing a multifaceted framework to enhance self-awareness and promote acceptance within the context of neurodiversity.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  85<IQ<115  Exclusion Criteria:  presence of other medical disorders - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 8 Years - MaximumAge: 14 Years - StdAgeList: Child
Social Relations Training for Children With ASD
Status: Recruiting

The following protocol was developed with the intention of significantly improving social skills by focusing on increasing relationship skills among children with ASD. Divided into two distinct parts, "Basic Social Relationships" and "Intermediate Social Relationships," the protocol has 4 stages for the former and 5 stages for the latter. Each phase is preparatory to the next, and in addition, a teaching procedure is implemented that adopts three prompt levels (partial, moderate and total), gradually aiming to reduce the assistance provided to encourage independent response. This gradual approach is designed to stimulate greater independence in social interactions.

The training lasts between 6 and 12 months, with one or two weekly group meetings lasting forty-five minutes each. Before the start and at the end of the protocol, participants are assessed using the Vineland scale to evaluate their adaptive behaviors.

The primary goal is to enable children with autism to develop meaningful social skills, providing them with concrete tools to interact more effectively and independently with their peers, thus improving their quality of life and social involvement. The protocol involves two distinct groups, experimental and control group.

The experimental group involves the use of a social robot that acts as a mediator in the interactions among participants. The role of the social robot is to facilitate, reinforce and support the participants' responses during the activities. The therapist coordinates with the social robot, helping to guide, reinforce and support participants' interactions.

In the control group, the therapist takes on the role of mediating interactions, helping and facilitating participants' responses. There is no involvement of a social robot; therefore,the therapist self acts directly to guide, reinforce and support the participants' social interactions.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  language in sentences Griffiths: QS>75  Exclusion Criteria:  presence of other medical disorders - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 5 Years - MaximumAge: 10 Years - StdAgeList: Child
Web-Based Cognitive Behavior Therapy for Procrastination
Status: Not yet recruiting

The main purpose of this study is to present the development process and project flow of an internet-based self-help intervention programme to reduce the level of procrastination among university students.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  volunteering to participate in the study being 18 years of age or older being an undergraduate student having internet access and an e-mail address with gmail extension getting a score above 3.5 points from the Tuckman Procrastination Behaviour Scale, having a score lower than 20 points for the depression sub-dimension, 15 points for the anxiety sub-dimension and 19 points for the stress sub-dimension of the DASS 21 scale (the participant is expected to meet all sub-dimension conditions).  Exclusion Criteria:  not being in a psychological help process not having any psychiatric diagnosis - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Evaluation of the Diagnostic and Prognostic Efficacy of MRI in Acute Sensorineural Hearing Loss and Ménière's Disease
Status: Recruiting

Evaluation of the diagnostic and prognostic efficacy of nuclear magnetic resonance imaging in patients with acute sensorineural hearing loss or in patients suffering from probable or definite MD. The neuroradiological and audiological evaluation are held on in the same day in order to better clarify the radiological and clinical correlates.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  age > 18 years  onset of symptoms less than 10 days no previous episodes of sudden ipsilateral hearing loss no systemic or oral corticosteroid intake in the previous month Informed consent  Exclusion Criteria:  Current or previous otopathy and/or labyrinth diseases of known cause Known nervous system disorders Patients with renal insufficiency (creatinine level > 1.5 mg/dL) Patients with pacemakers, other metal implants, claustrophobics and known psychiatric disorders Pregnant patients Materials and methods Diagnostic evaluation at enrollment (T0) Audiological or ENT examination Liminal tonal audiometric exam, vocal, impedance measurement, otoacoustic emissions, video-impulse test, oVEMPS, cVEMPS, stabilometry Hematological tests: complete blood count, ESR, PCR, creatininemia, CMV IgM, EBV IgM, ANA, glycemia, study of predisposing genetic factors - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Patients suffering from acute sudden hearing loss and Meniere's disease according to the criteria of the American Academy of Otolaryngology. - SamplingMethod: Probability Sample
Comparison of Absorbance Values, Sensory Evaluations and Periodontal Effects of Five Different Products for Clean Aligners Cleansing
Status: Recruiting

The aim of the study is to evaluate the most efficient product for the cleaning of Invisalign® clear aligners (Align Technology Inc., San Jose, CA, USA) through objective and subjective assessments after the use of 5 different products. For each aligner, one product is used for 2 weeks until all of them are used, therefore 5 different aligners are required for the study. A periodontal evaluation is conducted to assess variations during the time frame of the study.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients undergoing orthodontic treatment with Invisalign® clear aligners.  Exclusion Criteria:  Failing to follow cleaning method instructions Failing to fill in the questionnaires - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 14 Years - StdAgeList: Child, Adult, Older Adult
Impact of Ursodeoxycholic Acid Treatment on the Gallbladder Polyp Evolution
Status: Not yet recruiting

The goal of this observational study is to learn about the impact of ursodeoxycholic acid treatment on the gallbladder polyp evolution in patients with gallbladder polyps that undergo follow up. The main question it aims to answer is:

• Whether ursodeoxycholic acid could decrease the gallbladder polyp size and therefore spare unnecessary follow up or surgical interventions

Participants will be managed according to the standard practice of the department they are attended:

According to the established practice in the Department of Surgery, patients that either do not have an indication for cholecystectomy or decline the offered intervention, and are subjects for a follow up, are usually prescribed Ursodeoxycholic Acid, at 10-15 mg/kg/day for at least 6 months.
According to the standard practice of Gastroenterology Department, patients are followed up according to the published guidelines.

Researchers will compare the groups that receive or not ursodeoxycolic acid treatment to see if the polyp size evolution differs significantly.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients with gallbladder polyps eligible for standard follow up (without indication for cholecystectomy or patient decline surgery or polyps < 5mm without risk factors such as age>60 years, primary sclerosing cholangitis, asian ethnicity, sessile polypoid lesion)  Exclusion Criteria:  Patients with gallbladder polyps that received ursodeoxycolic acid doses lower than 10mg/kg/day - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Consecutive patients referred for an outpatient consultation to the Departments of Surgery and Gastroenterology due to gallbladder polyps. - SamplingMethod: Probability Sample
Exosome-based Liquid Biopsies for Upper Gastrointestinal Cancers Diagnosis
Status: Recruiting

This study constitutes a case-control investigation employing a retrospective approach. Plasma samples from individuals with esophageal cancer, benign esophageal diseases, gastric cancer, benign gastric diseases, and a healthy control group were systematically collected. Advanced Data-Independent Acquisition (DIA) proteomics and single-vesicle membrane protein detection techniques were employed to quantify protein content within exosomes. Specific protein biomarkers indicative of early-stage upper gastrointestinal tumors were identified. External validation of these protein markers was conducted using Parallel Reaction Monitoring (PRM) technology on an independent validation cohort. The objective is to establish protein marker predictions for early diagnosis of upper gastrointestinal tumors and prognostication of therapeutic efficacy.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Confirmed diagnosis of upper gastrointestinal cancers or benign upper gastrointestinal diseases through gastroscopy and pathological examination. Collection of plasma samples prior to surgical treatment. Availability of complete clinical data.  Exclusion Criteria:  Previous reception of anti-tumor treatments (including radiotherapy, chemotherapy, etc.) before blood collection. Coexistence of other systemic tumors. Absence of plasma sample collection before surgical treatment. Incomplete clinical data. Pregnancy status - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - StdAgeList: Child, Adult, Older Adult - StudyPopulation: The study population included a range of subjects with upper gastrointestinal cancers and diseases, including patients with malignant and benign upper gastrointestinal diseases and healthy controls, who were admitted to the main study center and other collaborating sub-center hospitals. - SamplingMethod: Non-Probability Sample