rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
Diagnostic Accuracy of Pocket-size Lung Ultrasound in Pneumonia Etiology and Complications in Hospitalized Children
Status: Not yet recruiting

Background and study aims Pneumonia is the leading infectious cause of death in children worldwide. Although the diagnosis is clinical, a chest radiograph (CXR) is often necessary to clarify it, exposing the patient to radiation. Ultrasound has been increasingly used in the evaluation of the lung parenchyma without exposing patients to radiation. The pocket-size Point-of-Care Ultrasound (POCUS) can be used at the patient's bedside proving comfort and saving time. Evidence suggests that ultrasound can detect CAP (community-acquired pneumonia) in children with similar accuracy and reliability as CXR. However, few studies evaluated the ability to distinguish the aetiology of pneumonia and none used a pocket-size POCUS device. This study aims to assess, for the first time, the diagnostic accuracy of a pocket-size POCUS device for the etiological diagnosis of CAP vs. CXR, in paediatric ages. Secondarily, the investigators intend to evaluate the correlation between CXR image vs. ultrasound, the correlation between clinical progression and ultrasound images, and the diagnostic accuracy to detect complications.

Who can participate:

The investigators will include, consecutively, all children aged >12 months and <18 years hospitalized to the Paediatric Department with the diagnosis of CAP on admission. The investigators will exclude children hospitalized with nosocomial pneumonia, with cystic fibrosis diagnosis or on long-term domiciliary ventilation.

What does the study involve:

The diagnostic accuracy between POCUS and CXR in differentiating the type of pneumonia will be assessed. All participants will perform a POCUS at admission, daily during hospitalization, 15 days and 1 month after discharge. All children will also undergo a CXR upon admission and whenever necessary.

What are the possible benefits and risks of participating:

Children will have a more frequent and serial assessment of CAP, which does not involve risks.

Where is the study run from:

The study if from Centro Materno Infantil do Norte - Centro Hospitalar Universitário de Santo António, a tertiary paediatric referral centre.

When is the study starting and how long is it expected to run for:

The recruitment period is expected to start in January/2024 and end in January 2025.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age >12 months and <18 years Hospitalization in the Paediatric Department CAP diagnosis on admission (based on the physician's clinical judgment, namely through clinical, analytical and/or CXR criteria)  Exclusion Criteria:  Nosocomial pneumonia Cystic fibrosis diagnosis Long-term use of domiciliary ventilation. - HealthyVolunteers: No - Gender: All - MinimumAge: 12 Months - MaximumAge: 18 Years - StdAgeList: Child, Adult
Needs Navigation for Caregivers of AYAs
Status: Recruiting

The overall aim of the study is to address unmet health-related social needs and reduce outcome disparities among AYA cancer survivors. Aim 1 aimed to refine a needs navigation model in partnership with expert consultants. Aim 2 and 3 will involve the deployment and pilot testing of the adapted needs navigation intervention among caregivers of younger AYAs with cancer.

Eligibility:
- EligibilityCriteria: Inclusion Criteria: We are enrolling dyads (AYA and caregivers) for this study.  AYA patient participants:  Age 15 - 26 years old English or Spanish-speaking In between 3-months of diagnosis of cancer date and up to 1-year post-treatment completion without progression or recurrence of cancer  Caregiver/financial partner participants:  Parent or financially-responsible adult of non-adult AYA (<18 years) OR Identified by the AYA as caregiver, parent, or partner who is financially-responsible or a financial partner for AYA  Exclusion Criteria:  Dyad with caregiver or younger AYA that previously participated in study AAAU2405 Unable to complete financial survey questions or contraindicated (as outlined in Protection of Human Subjects) Dyad with younger AYAs who are enrolled on hospice or receiving other end-of-life care - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 15 Years - MaximumAge: 26 Years - StdAgeList: Child, Adult
Rehabilitation Device for Hand Mirror Therapy
Status: Not yet recruiting

This study is a randomized and open comparative study that uses two parallel groups: a control group training with conventional therapy and another group that trains with the device "Miraπ". The participants are patients with stroke with motor weakness in one hand. Two measurement visits are required. During those visits, different hand function assessments will be carried out to analyze the motor function of the subjects hand. The measurements will be done during their inpatient rehabilitation stay, one at time of admission and the second at discharge, each taking 20 minutes. In the time between the measurement visits, the hand therapy takes place fivemtimes a week.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Participants currently accepted and cleared for rehabilitation in the inpatient rehabilitation unit by the rehabilitation medical director. Participants with paralysis or motor function problems of only one hand. Participants spasticity of the affected hand ( as assessed by by the occupational therapist) Participants need mirror therapy because of their health condition. Participants are able to memorize easy tasks, and able to follow instructions e.g., moving the healthy fingers.  Exclusion Criteria:  Participants who are not cleared physically or medically to participate in standard acute inpatient rehabilitation therapies by the rehabilitation medical director Participants who are not able to memorize easy tasks, e.g., moving the healthy fingers. Participants with spasticity of the affected hand ( as assed by the occupational therapist) Vulnerable populations - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Screening Anal HPV Colonization in Men Sex Men Using Pre-exposure Prophylaxis for HIV (ANAPreP'HPV)
Status: Recruiting

This is an interventional study investigating HPV carriage and liquid-based cytology at anal level. It will be offered to all patients undergoing PreP consultations at Besançon University Hospital. The anal swab will be taken by the doctor using a cyto-brush during the consultation.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Men sex Men Using Pre-exposure Prophylaxis for HIV Follow up au CHU de Besançon.  Exclusion Criteria:  Women No MSM Under 18 History of HPV related cancer - HealthyVolunteers: No - Gender: Male - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Trauma-Informed Guilt Reduction Therapy Compared to Prolonged Exposure
Status: Not yet recruiting

The goal of this clinical trial is to learn if receiving Trauma-Informed Guilt Reduction (TrIGR) Therapy is as effective as receiving Prolonged Exposure Therapy among veterans with PTSD and trauma related guilt. The main questions it aims to answer are:

Will TrIGR be comparable to PE in terms of PTSD symptom reduction? Will it TrIGR be comparable to PE in improving functioning and reducing depression symptoms? Will it be superior in improving trauma-related guilt and shame?

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  U.S. Veterans age 18 or older who served in the military since the start of Operation Enduring Freedom/Operation Iraqi Freedom; OEF/OIF) meets diagnostic criteria for PTSD; a score of 2 or higher ("true" to "extremely true") on feeling trauma-related guilt much or all of the time or scoring 3 or higher ("very true" or "extremely true") on at least one guilt cognition factor (hindsight bias/responsibility, wrongdoing, or lack of justification) on the Trauma Related Guilt Inventory not currently receiving trauma-focused treatment such as PE or CPT willingness to attend psychotherapy and assessment sessions  Exclusion Criteria:  current risk of suicidal/homicidal behavior that requires immediate intervention current severe substance use disorder (in the past two months) based on DSM-5 criteria current unmanaged psychosis or mania life threatening or unstable medical illness inability to read - HealthyVolunteers: No - Gender: All - GenderBased: Yes - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Acceleration Time Assessment for Prediction of Critical Limb Ischemia
Status: Not yet recruiting

Critical Limb Ischaemia (CLI), the final stage of arterial disease, is a therapeutic emergency whose prognosis depends largely on the time taken to diagnose it. The growing prevalence of this condition and the associated healthcare costs make it an important public health objective. Diagnostic criteria for Critical Limb Ischaemia differ between learned societies and countries.

Its diagnosis is most frequently based on the combination of a clinical criterion (ischaemic decubitus pain and/or necrotic wounds, with a time to onset > 2 weeks) and a haemodynamic criterion (ankle systolic pressure (ASP) < 50mmHg or toe systolic pressure (TSP) < 30 mmHg or transcutaneous oxygen pressure (TCPO2) < 30 mmHg).

Recent studies have highlighted the importance of pulsed Doppler flow analysis in quantifying arteriopathy of the lower limbs, both by systematically analysing flow modulation and by measuring the systolic rise time of distal arteries (dorsal artery of the foot and lateral plantar artery).

The main aim of our study is therefore to validate a reliable and accessible diagnostic tool for screening patients suffering from CLI so that they can be referred to a reference centre as early as possible.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age ≥ 18 years; Patient referred to the vascular medicine department of one of the investigating centres for arterial Doppler ultrasound of at least one lower limb and for whom a measurement of the systolic pressure index at the toe will be performed.  Presence of proven arterial disease, asymptomatic or not, defined by the presence of one of the following criteria:  Rest ankle systolic pressure index ≤ 0.90 Rest toe systolic pressure index ≤ 0.70  Exclusion Criteria:  Patient with haemodynamic instability, unable to tolerate a delay in therapeutic management caused by the ultrasound examination and measurement of systolic pressure at the toe; Patients with surgical management of the lower limb (in relation to lower limb arteriopathy), already scheduled at the time of inclusion. Patients with a life expectancy of less than 24 hours; History of transmetatarsal amputation or amputation at a more proximal level compromising the measurement of systolic pressure and occlusion at the toe and/or TCPO2; Refusal to participate - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Patient referred to the vascular medicine department of one of the investigating centres for arterial Doppler ultrasound of at least one lower limb - SamplingMethod: Non-Probability Sample
Enhancing Digitally Delivered Diabetes Education With Real-Time CGM
Status: Not yet recruiting

The current research study will add continuous glucose monitoring devices to the evidence-based text messaging diabetes education program for patients with type 2 diabetes for 6 months. Results on the effectiveness of this intervention will be compared for non-insulin using patients.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Diagnosed with type 2 diabetes Are on non-inuslin therapies HbA1c 7.5% to greater than or equal to 12.0% Access to a mobile phone that accepts texts and counts steps  Exclusion Criteria:  Are using insulin therapies Are pregnant Are currently participating in another CGM-related study - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Effectiveness of Balance Training And Dynamic Neuromuscular Stabilization Training in Amateur Athletes With Chronic Ankle Instability
Status: Recruiting

The goal of this clinical trial is to determine and compare the effects of balance and dynamic neuromuscular stabilization training on ankle function ability, functional instability severity, physical activity level, muscle strength, proprioception, stabilization, balance, reaction time and performance of amateur athletes with chronic ankle instability. The main questions it aims to answer are:

Do balance and dynamic neuromuscular stabilization training positively affect functionality, balance, stabilization, proprioception and performance in amateur athletes with chronic ankle sprains?
Does balance training or dynamic neuromuscular stabilization training have a more positive effect on functionality, balance, stabilization, proprioception and performance in amateur athletes with chronic ankle sprains?

Participants will apply:

a dynamic neuromuscular stabilization training program consisting of a series of special exercises based on the developmental kinesiology steps of a healthy baby.
balance training which consist of an effective postural stability program.
conventional training program which consist of stretching, joint range of motion, strengthening and postural control exercises.

Researchers will compare balance and dynamic neuromuscular stabilization training to see if effectiveness of ankle function ability, functional instability severity, physical activity level, muscle strength, proprioception, stabilization, balance, reaction time and performance.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Being between the ages of 18-25 Being a non-smoker Being an athlete at amateur level Score 25 or less on the Cumberland Ankle Instability Questionnaire At least 1 acute ankle inversion sprain resulting in swelling, pain, and dysfunction that occurred at least 12 months before the study Feeling of giving way in the ankle at least 2 times in the last 6 months  Exclusion Criteria:  If the patient has any mental problems Neurological diseases Cerebellar, vestibular, cochlear and inner ear dysfunction Surgeries on musculoskeletal structures, chronic musculoskeletal disorders, severe acute lower extremity injuries or head trauma in the last 6 months - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 25 Years - StdAgeList: Adult
Effect of Footcore Exercises on Navicular Drop and Plantar Pressure Distribution in Asymptomatic Individual With Flatfoot
Status: Recruiting

Pes Planus is a medical condition in which arch of the foot is flattened, causing the entire sole of the foot to contact the floor. For those with flat feet, footcore exercises might be an effective non-invasive therapy. Footcore exercises aim to strengthen the intrinsic foot muscles that maintain the foot arch, enhance foot function and reduce the risk of injury in persons with flatfoot.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Individuals having flat feet. those with a height difference of ≥ 10 mm during the navicular drop test. No history of foot or ankle surgery.  Exclusion Criteria:  Any lower limb injury Healing fracture of lower limb33 Any neuromuscular disorder 25 Recent surgery Any open wound. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 30 Years - StdAgeList: Adult
Application of L-PRF in Periodontal Surgery
Status: Recruiting

The study will compare the clinical outcomes of the two procedures, open flap debridement (OFD) compared to open flap debridement with leukocyte and platelet-rich fibrin (L-PFR) as well as differences in patient postoperative pain perception.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients between age 18 and 89 Patients needing open flap debridement procedures for periodontal disease in one or more teeth in the same arch bilaterally (split mouth) Patients must be nonsmokers, former smokers, or current smokers who smoke <10 cigarettes per day, by self-report Female patients to include non- pregnant women of child-bearing potential.  Exclusion Criteria:  Patients who disclose that they will not be able to cooperate with the follow-up schedule. Patients who are mentally incompetent, prisoners, or pregnant (as obtained via chart review or self-report) Pregnant women or women intending to become pregnant during the study period Smokers who smoke > 10 cigarettes per day - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 89 Years - StdAgeList: Adult, Older Adult
Safer Aging With Diabetes Monitoring
Status: Not yet recruiting

Older adults with type 2 diabetes are at higher risk for severe hypoglycemia and its related complications (including hospitalization and death) when taking insulin. This study proposes to evaluate, in a randomized clinical trial, a strategy of safe insulin prescribing based on an educational program that leverages continuous glucose monitoring to support older adults at high risk for hypoglycemia. If the aims of this project are achieved, this novel care strategy could be widely applied to reduce severe hypoglycemia episodes in older, high-risk adults with type 2 diabetes.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age 75 years and older Diagnosis of Type 2 Diabetes Current treatment with insulin Increased hypoglycemia risk (prior year hypoglycemia by self-report or utilization) Able to communicate in English Able to access email and the Internet  Exclusion Criteria:  On renal dialysis Dementia Pacemaker or Automatic Implantable Cardioverter Defibrillator Using insulin pump Severe Mental Illness Severe Visual Impairment In Hospice Current or recent CGM use - HealthyVolunteers: No - Gender: All - MinimumAge: 75 Years - StdAgeList: Older Adult
De Quervain's Disease in the Acute Phase:a Study Aimed at Evaluating the Effectiveness of Standard Physiotherapy Treatment (HANDGUIDE), Compared to Experimental Treatment After Performing Ultrasound-guided Infiltrative Therapy.
Status: Recruiting

The objective of the study is to compare pain reduction and disability reduction in two groups of patients diagnosed with de Quervain syndrome who will undergo ultrasound-guided infiltrative treatment with corticosteroid as per normal clinical practice:

the control group will subsequently be subjected to a standard treatment based on the European guidelines of the HANDGUIDE group,
the experimental group will subsequently carry out a program of eccentric exercises.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients of both sexes with a minimum age of 18 years; Medical diagnosis of de Quervain syndrome assessed through orthopedic clinical examination e confirmation by ultrasound; Signing of the informed consent and participation in the study.  Exclusion Criteria:  Patients who are not self-sufficient or not able to understand and want; Presence of other pathologies in the hand affected by de Quervain pathology, such as intersection syndrome, neuropathies, fractures, rhizoarthrosis, arthrosis of the radio-carpal or intercarpal joint, intercarpal instability, cervical radiculopathy, rheumatic or metabolic pathologies; Pregnant or breastfeeding women. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Radiographic Changes in the Maxillary Sinus Following Closed Sinus Augmentation
Status: Recruiting

A closed sinus augmentation is performed for dental implant placement.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Partially edentulous patients (18-85 years of age) requiring maxillary sinus augmentation for dental implant placement. At least 5mm of native bone below the maxillary sinus. Nonsmokers. If diabetic, current HbA1C <7.0 (less than or equal to 7.0)  Exclusion Criteria:  Maxillary sinus disease. Pregnancy or attempting to become pregnant. Diseases that affect bone metabolism. Use of medications known to affect bone metabolism. Tobacco use. Alcoholism or recreational drug use. Diabetic with HbA1C >7.0 (above 7.0) - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 85 Years - StdAgeList: Adult, Older Adult
Disability of People With Fibromyalgia in Poland
Status: Not yet recruiting

Fibromyalgia is a syndrome characterized by chronic, generalized pain in muscles and joints with the presence of characteristic, symmetrically occurring so-called "tender points" - areas of the body that are excessively sensitive to pressure. The condition is associated with a feeling of chronic fatigue, mood and sleep disturbances and a sensation of body stiffness. These complaints are bothersome and significantly impair patients' functioning in every aspect of their lives. There are few studies evaluating the functioning and disability of people with fibromyalgia. No such study has been conducted in Poland to date. Therefore, the purpose of this study is to evaluate the functioning and disability of fibromyalgia patients and the relationship of the level of disability with selected factors, such as pain intensity, emotional state, sleep quality, etc.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  People aged 18 and over People suffering from fibromyalgia People who give informed consent to participate in the study  Exclusion Criteria:  Tłumaczenie  Underage persons People without fibromyalgia People who do not give informed consent to participate in the study - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Adults with fibromyalgia in Poland. - SamplingMethod: Probability Sample
Extended Reality-Assisted Therapy for Chronic Pain Management
Status: Not yet recruiting

The goal of this clinical trial is to test a home-based virtual reality rehabilitation application in patients with chronic low back pain. The main question it aims to answer are:

Is a prototype of a novel VR software application effective at reducing pain, improving daily function, improving range of motion, and reducing fear of movement in adult patients with chronic low back pain compared with a passive VR intervention? Participants in the treatment group will use the application daily for 20 minutes for a period of 3 weeks at home and unsupervised. Researchers will compare use of the VR application with a control group that watches 2D video to see if the treatment group have improved pain, disability, range of motion, and fear of movement.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Adults aged 18-65 of either sex Diagnosis of chronic low back pain of >12 weeks, with or without associated somatic referred leg pain Average pain intensity over the previous month ≤7/10 and ≥ 2/10)  Exclusion Criteria:  Spondylolysis, fracture, cauda equina syndrome, active spinal infection Acute radiculopathy or compromised nerve root Recent spinal surgery (<12 months) or lower limb surgery (<3 months) Major depressive symptoms as indicated by the Patient Health Questionnaire-2 depression screen score of 4 or more. Current or prior diagnosis of epilepsy, seizure disorder, dementia, migraines, balance disorder, or other neurological diseases that may prevent the use of virtual reality or adverse effects. Cardiopulmonary or pulmonary disorder with contraindication to physical exercise Pregnancy - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult