rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
Can a Novel Manual Therapy Technique Help Relieve Stress? Assessing Effects of Primal Reflex Release on the Body's Stress Response
Status: Not yet recruiting

Stress, when left unmanaged, can have detrimental effects on both physical and mental health, contributing to conditions such as high blood pressure, anxiety, and even cardiovascular disease. Effective stress management therapies may help maintain overall well-being and reduce the risk of long-term health complications. The Primal Reflex Release Technique (PRRT) is a novel manual therapy that may reduce markers related to stress such as heart rate variability (HRV) and patient-reported outcomes (PROs). Therefore, the purpose of this study is to elucidate the potential for PRRT to improve HRV and PROs.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Subject can refrain from caffeinated beverages in the 6 hours prior to data collection Subject is not currently taking any beta blockers Subject is comfortable with a manual therapy technique where the clinician touches your face and head  Exclusion Criteria:  Subject has had caffeine within 6 hours Subject is currently taking any beta blockers - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 64 Years - StdAgeList: Adult
A CCTA Imaging Trial to Evaluate the Effect of Obicetrapib/Ezetimibe on Coronary Plaque
Status: Not yet recruiting

This placebo-controlled, double-blind, randomized, Phase 3 study is being conducted in adult participants with high-risk atherosclerotic cardiovascular disease (ASCVD) who are not adequately controlled by their maximally tolerated lipid-modifying therapy, to assess the impact of the obicetrapib 10 mg + ezetimibe 10 mg FDC daily on coronary plaque and inflammation characteristics, evaluated using cardiovascular computed tomography angiography (CCTA).

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  LDL >70md/dL Total coronary plaque > 75mm3 BMI 18-40 Max tolerated lipid modifying therapy eGFR greater/equal to 40  Exclusion Criteria: - HbA1c >10  Contraindications for CCTA History of coronary artery bypass graft Active liver disease - HealthyVolunteers: No - Gender: All - MinimumAge: 45 Years - StdAgeList: Adult, Older Adult
Efficacy of Photodynamic Therapy and LASER Disinfection in Periodontal Therapy for Treatment of Periodontitis
Status: Recruiting

The goal of this clinical trial is to Investigate the clinical and microbiological efficacies of Laser disinfection and ICG-mediated aPDT as adjunct to RSD for patients with periodontitis. The main question it aims to answer is:

Does the use of laser disinfection or ICG-mediated aPDT as adjunct to RSD are effective in improving clinical parameters and reducing the load of periodontal pathogens.

Participants will undergo full-mouth supragingival debridement by using ultrasonic device at baseline.

All patients will be instructed to brush their teeth twice daily and will be supplied with the same type of tooth paste and toothbrush, with suitable interdental aids.

All the patients will be instructed to attend again after 7 days. One week later, sites randomly allocated to control (Ctrl) group and test groups which will receive, in addition to RSD, either aPDT or periodontal pocket disinfection (Biolase). For all groups, sites with initial PPD 4-6 mm will be treated with RSD using area specific (Graecy) curettes.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Adult subjects (>18 years), non-smoker, with no history of any systemic disease such as diabetes mellitus. Additionally, subjects are not currently under active periodontal therapy or joining other trial in the last 3 months. All patients must be diagnosed with generalized periodontitis with at least 3 teeth in three different sextants (Anterior teeth and premolars) with 4-6 mm PPD and positive BOP. Periodontitis cases will be defined by presence of interdental CAL affecting ≥2 non adjacent teeth or if CAL at buccal/lingual aspects associated with PPD >4mm at ≥2 teeth.  Exclusion Criteria:  Patients will be excluded if they were not diagnosed with periodontitis, smokers, those consuming antibiotics, regular user of nonsteroidal anti-inflammatory drugs, or receiving periodontal treatment 3-months prior to the study. Additionally, pregnant or mothers in a breastfeeding period, and those not willing to participate will be also excluded. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Differents Laser Applications on Plantar Fasciitis
Status: Not yet recruiting

The objective of this randomized controlled clinical trial (RCT) with a double-blind technique and longitudinal chronology, entitled &#34;Effect of different laser applications on Plantar Fasciitis&#34;, is to evaluate and compare the effectiveness of laser therapy low-level (LLLT) in local spot mode versus sweep mode in the reduction of pain associated with plantar fasciitis.

The main questions it seeks to answer are:

What is the comparative effectiveness between low-level laser therapy in local spot mode and sweep mode in reducing pain in patients with plantar fasciitis?
What are the optimal therapeutic parameters (session duration, frequency and power) for LLLT in both modes, maximizing pain reduction in patients with plantar fasciitis?

Participants in this study will perform the following tasks:

Undergo low-level laser therapy sessions in local spot mode or sweep mode.
Comply with the instructions on the duration and frequency of the sessions.
Record the pain levels experienced before and after each session.

The investigators will compare the group undergoing local spot mode low-level laser therapy with the group undergoing sweeping mode low-level laser therapy to evaluate whether there are significant differences in pain reduction effects.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Confirmed Diagnosis of Plantar Fasciitis  Exclusion Criteria:  Additional Serious Medical Conditions - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: subjects who present plantar fasciitis and go to the podiatry clinic within the indicated period - SamplingMethod: Probability Sample
Genitourinary Syndrome of Menopause in Thai Gynecologic Cancer Survivors
Status: Not yet recruiting

Women often face common cancers like ovarian, uterine, and cervical cancers. Improvements in cancer detection and treatment mean more women survive. However, survivors can encounter challenges like ongoing pain, treatment complications, and fertility issues.

Treating these cancers often involves surgeries that might include removing ovaries or using pelvic radiation. This can trigger menopause in younger women, causing problems like vaginal dryness, itching, and urinary issues.

Women who've gone through menopause often deal with these symptoms, affecting their daily lives, confidence, and intimate relationships. Though treatments are available, lack of awareness, embarrassment, and not discussing these issues with doctors can make managing them difficult.

The main treatment for these symptoms is using vaginal estrogen, but it might not be suitable for some cancer survivors. Non-hormonal options like lubricants and moisturizers are alternatives. This study in Thailand aiming to explore how common these issues are among gynecological cancer survivors, their feelings about it, and how it affects their quality of life.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Participant with gynecologic cancer (cancer of ovary, fallopian tube, uterus, cervix, vagina, and vulva.) Time passed more than 6 months since last cancer treatment.  Exclusion Criteria:  Participant not entering menopause after cancer treatment. Participant with cancer progression. Participant currently suffer from severe pain, fatigue, or discomfort. Participant deny to participate. - HealthyVolunteers: No - Gender: Female - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Gynecologic cancer survivors, age more than 18 years old that came to the Gynecology Clinic at Khon Kaen University Hospital for routine cancer surveillance. - SamplingMethod: Probability Sample
Glaucoma Evaluation With the P200TE
Status: Recruiting

Images captured on the P200TE device on glaucoma patients

Eligibility:
- EligibilityCriteria: Inclusion Criteria  Subjects were 22 years of age or older on the date of informed consent;  Subjects were able to understand the written informed consent and willing to participate as evidenced by signing the informed consent;  BCVA 20/40 or better in the study eye;  History of visual field defects within the previous year from the study visit or measured the day of the study visit consistent with glaucomatous optic nerve damage with at least one of the following two findings:  On pattern deviation (PD), there existed a cluster of 3 or more points in an expected location of the visual field depressed below the 5% level, at least 1 of which is depressed below the 1% level; or  Glaucoma hemi-field test "outside normal limits;"  Glaucomatous optic nerve damage as evidenced by any of the following optic disc or retinal nerve fiber layer structural abnormalities:  Diffuse thinning, focal narrowing, or notching of the neuroretinal rim, especially at the inferior or superior poles with or without disc hemorrhage; and  Optic disc neural rim asymmetry of the two eyes consistent with loss of neural tissue.  Exclusion Criteria  Subjects unable to tolerate ophthalmic imaging;  Subjects with ocular media not sufficiently clear to obtain acceptable OCT images in the study eye;  Subject has a condition or is in a situation which the investigator feels may put the subject at significant risk, may confound the study results, or may interfere significantly with the subject's participation in the study;  No reliable visual field test result within the past year of the study visit, defined as fixation losses > 33% or false positives >33%, or false negatives >33% in the study eye;  Presence of any ocular pathology except glaucoma in the study eye. - HealthyVolunteers: No - Gender: All - MinimumAge: 22 Years - StdAgeList: Adult, Older Adult
Prognosis of Disseminated and Cerebral Toxoplasmosis Hospitalized in Intensive Care in the Era of PCR Diagnosis
Status: Not yet recruiting

Toxoplasmosis is a common infection whose clinical severity can sometimes justify admission to intensive care, especially in immunocompromised patients.

This study should make it possible to evaluate the impact of different anti-infective treatment regimens and to highlight clinical-biological and prognostic differences depending on the type of underlying immunosuppression.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Adult patient hospitalized in intensive care At least 1 organ failure (SOFA> or =2) PCR toxoplasmosis on CSF, blood, BAL, or bone marrow positive within 7 days before or after admission to ICU  Exclusion Criteria:  Post-mortem diagnosis Primary outcome not available Patient living informed and not opposed to the reuse of their data in this research. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 100 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Patients hospitalized in intensive care for toxoplasmosis (positive toxoplasmosis PCR) between 2012 (01/01/2012) and 2023 (02/01/2023) - SamplingMethod: Non-Probability Sample
Resistance Profile of Escherichia Coli in Infections of Community Origin: The Importance of Antimicrobial Stewardship
Status: Not yet recruiting

The main objective of the study is to describe the antimicrobial resistance profile of E. coli isolated in patients from the community - defined as those with cultures collected within 48 hours of hospital admission - and admitted to the intensive care unit.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  All 18 years and old patients admitted to the ICU Positive cultures for E. coli Any sample collected within 48 hours of hospital admission  Exclusion Criteria:  Lack of necessary data - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Adult patients with severe Escherichia coli infections, isolated from any culture material collected within less than 48 hours of hospital admission, admitted to the intensive care unit of a tertiary hospital. - SamplingMethod: Probability Sample
Microbiota Directed Food for Children With Moderate Acute Malnutrition
Status: Not yet recruiting

Moderate acute malnutrition (MAM) refers to a condition characterized by a significant deficit in weight-for-length measurements in children aged 6 to 59 months. It is a crucial public health concern with detrimental effects on child growth, development, and overall well-being. Addressing MAM is crucial to prevent its progression to severe acute malnutrition (SAM) and to ensure healthy child development. To meet the nutritional requirement of MAM children, icddr,b have come up with a novel intervention named microbiota-directed food (MDF), a ready-to-use supplementary food.we propose this efficacy trial to establish the evidence on the effect of this novel intervention on ponderal growth, microbial and proteomic recovery among the children with MAM in comparison to the standard RUSF.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Parent(s) willing to sign consent form Children aged 6-24 months WLZ score <-2 to ≥-3 and/or MUAC ≥115 mm to <125 mm without bilateral pedal edema at the time of randomization  Exclusion Criteria:  Medical conditions: Malnourished children with complications requiring acute phase treatment in a hospital, children with tuberculosis or any chronic illness(es). Any congenital/acquired disorder affecting growth, i.e., known case of trisomy-21 or cerebral palsy; children on an exclusion diet for the treatment of persistent diarrhea; having known history of soy, peanut or milk protein allergy Severe anaemia (< 8 gm/dl) Antibiotic use (within last 7 days before the onset of intervention) Receiving concurrent treatment for another condition children participating in other food intervention program - HealthyVolunteers: No - Gender: All - MinimumAge: 6 Months - MaximumAge: 24 Months - StdAgeList: Child
Encouraging Positive Parenting Habits Through Digital Media: Feasibility Study
Status: Not yet recruiting

This study evaluates the feasibility and preliminary impacts of a new parenting program consisting of a series of educational videos, automatically delivered via a popular texting platform. The program content for the feasibility study is focused on teaching parents strategies to better manage one of the commonly reported challenges that children face, a transition to a non-preferred activity. Parents with young children experiencing behavior difficulties with daily transition routines are invited to participate in the study.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Parents of children, aged 4-10, experiencing behavior difficulties with daily transition routines (parent-report).  Exclusion Criteria:  Children not living with participating parents at least 5 days per week every week. While participating parents are informed that the program was developed for children demonstrating symptoms of ADHD, the low symptom number will not be used as an exclusion criteria. - HealthyVolunteers: No - Gender: All - MinimumAge: 4 Years - MaximumAge: 10 Years - StdAgeList: Child
VEXUS and NGAL in the Diagnosis and Prognosis of Sepsis-associated Acute Kidney Injury
Status: Not yet recruiting

In this prospective observational study, patients hospitalized in our mixed intensive care unit, aged between 18 and 80, and diagnosed with sepsis and septic shock according to sepsis-3 criteria will be included.

To determine whether patients develop AKI during the first five days of ICU admission, creatinine and urine output will be monitored daily for the first five days of ICU admission according to KDIGO criteria. Clinical diagnosis and treatment of AKI will be made according to KDIGO.

According to KDIGO, patients will be divided into two groups: those who develop AKI and those who do not.

By comparing plasma NGAL and VEXUS scores between groups, the sensitivity and specificity of the VEXUS score in determining AKI will be determined.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  sepsis septic shock  Exclusion Criteria:  Poor abdominal echogenicity, other conditions causing shock (hypovolemic, cardiogenic, neurogenic), life expectancy less than 24 hours, pregnancy, vasospastic disease, intraperitoneal pressure > 15 mm Hg, obstructive renal failure liver and kidney transplanted patients, liver and kidney tumors, patients receiving dialysis treatment, single kidney and other kidney abnormalities, right heart failure, acute mesenteric ischemia chronic renal failure - Gender: All - MinimumAge: 18 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult - StudyPopulation: sepsis and septic shock in ICU - SamplingMethod: Probability Sample
Fully Hybrid 18F-PSMA PET/MRI as One-stop Approach for the Diagnosis of Clinically Significant Prostate Cancer.
Status: Recruiting

This project aims to evaluate the role of fully hybrid PET/MRI with 18FPSMA and multiparametric MR imaging (mpMRI) as one-stop approach for the diagnosis of clinically significant prostate cancer (csPCa).

Our main hypothesis is that adding 18F-PSMA PET to mpMRI prior to biopsy, will reduce the number of false negative findings, while at the same time, allowing also to reduce the number of unnecessary prostate biopsies in patients with low-risk, clinically indolent PCa.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Men at least 18 years of age referred with clinical suspicion of prostate cancer candidate for prostate biopsy Feasibility to undergo all procedures listed in protocol Ability to provide written informed consent  Exclusion Criteria:  Prior diagnosis of prostate cancer Contraindication to MRI (e.g. claustrophobia, pacemaker, estimated GFR lower or equal to 50mls/min) Contraindication to prostate biopsy - HealthyVolunteers: No - Gender: Male - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Men with clinical suspicion of clinically significant prostate cancer (csPCa). - SamplingMethod: Probability Sample
Achieving Rapid, Safe and Sustained Glucose Control in Adolescents With Suboptimally Controlled Type 1 Diabetes Using Advanced Hybrid Closed Loop Systems
Status: Not yet recruiting

The rational of this study is to assess if AHCL systems are able to achieve a better metabolic control (better glucometric data) after 2 weeks, 1 months. 6 months and 1 year after the start, in adolescents in not good glycaemic control.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  All children met the American Diabetes Association (ADA) criteria for T1D diagnosis with a current HbA1c of ≥8.5%.  Age range 12-17 yrs old  Exclusion Criteria:  Patients with a diagnose of genetic form of diabetes will be excluded. - HealthyVolunteers: No - Gender: All - MinimumAge: 12 Years - MaximumAge: 17 Years - StdAgeList: Child - StudyPopulation: diabetics adolescents in not good glicaemic control - SamplingMethod: Non-Probability Sample
Predicting Adenomatous Polyps in the Colon Using Images of a Human Tongue
Status: Recruiting

This is a prospective, multicenter, single-arm clinical investigation designed to evaluate the accuracy of the Gixam™ System in identifying subjects with colorectal adenomas compared to optical colonoscopy. Subjects arriving for a standard of care colonoscopy at the investigation site will be offered to participate in the study. Following an informed consent process, images of the subjects' tongue will be obtained with the Gixam™ System and a prediction score will be generated by the Gixam™ AI model. Subjects will thereafter proceed to their SOC colonoscopy, and the Gixam™ score will be compare with colonoscopy findings to evaluate its performance.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Males or females Age: 18-75 years, inclusive  Scheduled for colonoscopy procedure at investigation site subject to one of the below criteria:  Screening - defined as first colonoscopy or consecutive colonoscopy without previous findings, previous colonoscopy performed at least 10 years ago (- 1 year); Patient with finding of colorectal adenoma or sessile serrated polyp in previous colonoscopy (must be documented in patient's medical history). Able to comprehend and provide informed consent.  Exclusion Criteria:  Subject who is not a suitable candidate for a colonoscopy Lynch or Familial Adenomatous Polyposis (FAP) inherited syndromes Current or previous Inflammatory Bowel Disease (IBD - Crohn's, Ulcerative Colitis) of significant duration Patients with a disability to extend their tongue. Patients with tongue piercings. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 45 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult
Community Services Navigation to Advance Health Equity in Breast Cancer Screening
Status: Not yet recruiting

The goal of this study is to evaluate if adding community services navigation to the standard referral process for social needs is an effective and scalable strategy for addressing disparities in follow-up to abnormal breast cancer screening results. The investigators will determine the effectiveness of social needs referrals combined with a community services navigation intervention in the screening mammography setting to improving breast screening outcomes in underserved women.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  English and Spanish speakers Received an abnormal result of a screening mammogram Self-reports at least one social need on the B-SINCERE Screener  Exclusion Criteria:  -Prior diagnosis of breast cancer - HealthyVolunteers: No - Gender: All - GenderBased: Yes - GenderDescription: Female - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult