Drainage Fluid Biomarkers and Postoperative Gastrointestinal Dysfunction in Laparoscopic Colorectal Surgery
Status: Recruiting

Postoperative gastrointestinal dysfunction (POGD), often referred to as postoperative ileus (POI) after colorectal surgery, is characterized by symptoms such as nausea, vomiting, abdominal distension, and delayed bowel movements. The incidence of this issue varies among medical institutions, impacting patient nutrition, prolonging hospital stays, and increasing healthcare costs.

The complex pathogenesis of POGD involves a brief neurogenic phase (within 3 hours) and a more prolonged inflammatory phase (beginning at 3-4 hours and lasting for days). The inflammatory phase is crucial and is recognized as initiated by mast cells and damage-associated molecular patterns that activate macrophages in the intestinal muscle layer. Subsequently, it triggers a series of cascading inflammation reactions through the release of inflammatory factors and recruitment of inflammatory cells, which contributes to the development and exacerbation of POGD. Studies have demonstrated changes in inflammatory cells and factors in the abdominal fluid following abdominal surgery, emphasizing the clinical significance of analyzing drainage fluid to predict postoperative gastrointestinal function.

This study analyzes inflammatory markers in drainage fluid following laparoscopic colorectal cancer surgery. The aim is to enhance the accuracy of predicting gastrointestinal recovery outcomes and contribute to the evolving field of Enhanced Recovery After Surgery (ERAS).

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Preoperative diagnosis of colorectal cancer through colonoscopy biopsy. Patients aged 18-80 years. Underwent laparoscopic radical resection for colorectal cancer with confirmed postoperative pathology. No prior radiotherapy, chemotherapy, or immunotherapy before surgery. Voluntary participation in the study and signing of a written informed consent form.  Exclusion Criteria:  Pregnant or lactating women. Severe liver dysfunction (Child-Pugh class B or above); severe renal dysfunction (serum creatinine level greater than 177). Patients with severe heart failure, chronic obstructive pulmonary disease, and other underlying diseases. Patients with pre-existing severe infections (developing sepsis or not improving after antibiotic treatment) before surgery. Patients with postoperative fistulas or those requiring a two-stage anastomosis. Intraoperative and postoperative intraperitoneal chemotherapy. Blood disorders (leukemia, lymphoma, aplastic anemia, etc.). Patient or family member withdraws midway. Those with serious post-operative infections (e.g., incisional, lung, and urinary tract infections) Intraoperative conversion to open laparotomy. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Patients aged 18-80 with preoperative colorectal cancer diagnosis through colonoscopy biopsy underwent laparoscopic radical resection, excluding prior radiotherapy, chemotherapy, or immunotherapy, and voluntarily participated by signing informed consent. - SamplingMethod: Non-Probability Sample