rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
Towards Optimal Fertility, Fathering and Fatherhood studY
Status: Not yet recruiting

This case-control study involving fertile and subfertile couples aims to identify male factors related to pregnancy likelihood, create a fertility index measure combining male and female factors to predict pregnancy likelihood, and examine how male factors relate to the semen physical and biological characteristics.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Subfertile couples:  men aged ≥21-49 years men with a female partner aged 21-39 years couples who are not able to conceive for at least 12 months couples who are Singapore citizen or permanent resident  Fertile couples:  men aged 21-49 years men with a female partner aged 21-39 years men with proven fertility defined as those female partners who are currently pregnant and with viable intrauterine pregnancy at gestational weeks of less or equal to 16 at the time of the study couples with attempted time to conceive within 12 months to achieve this pregnancy or with unplanned pregnancy couples who are Singapore citizen or permanent resident  Exclusion Criteria:  Subfertile couples:  male infertility of a known aetiology including azoospermia, retrograde ejaculation, genetic disorders, cancer treatment, or testes trauma female infertility diagnosis as confirmed by diagnostic imaging or having severe endometriosis female partners with irregular menstrual cycle >35 days couples with known chromosomal abnormalities  Fertile couples:  couples who achieve pregnancy after oocyte or spermatozoa donation couples with known chromosomal abnormalities female partners with known uterine abnormalities - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - GenderBased: Yes - GenderDescription: Based on biological sex identity for males and females - MinimumAge: 21 Years - MaximumAge: 49 Years - StdAgeList: Adult - StudyPopulation: The subfertile couples will be recruited from the infertility clinics, while the fertile couples will be recruited from the antenatal clinics. Both groups will also be recruited from on-going preconception and pregnancy programs in the hospital. - SamplingMethod: Non-Probability Sample
Effects of Acupoint Massage Around Eyes on Ocular Biological Indexes
Status: Recruiting

This study aims to investigate whether the acupoint eye exercise could impact the biological parameters of the eye.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  healthy people of all ages  Exclusion Criteria:  presence of systemic diseases history of other eye diseases, surgeries, and/or medications, as well as eye trauma incomplete healing of the surgical site after eye surgery consumption of coffee, tea, or vasodilators within 6 hours before the commencement of the test exclusion of children, pregnant, and lactating women - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult
The Effect of Artificial Intelligence Supported Mobile Learning on Nutrition/Hydration Control and Individual Management
Status: Not yet recruiting

The adherence to recommended nutrition and fluid restrictions is crucial for the success of hemodialysis treatment. However, approximately 80% of patients receiving HD treatment are non-compliant with fluid restriction, leading to various complications. Cardiovascular complications are among the most common complications associated with this issue. When reviewing national and international literature on the subject, it is observed that in order to improve treatment adherence in HD patients, written materials are often used in addition to individual or group education sessions, focusing mainly on assessing patients&#39; quality of life and self-efficacy. However, a mobile-supported learning method that enables patients to manage their nutrition and fluid control individually is not commonly utilized.

This research aims to investigate the impact of an artificial intelligence-supported mobile application developed for HD patients on the control of nutrition/fluid intake and individual management.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  18 years and over, Conscious and able to communicate, Having received hemodialysis treatment for the last 3 months, Able to use an Android-based phone (for those who do not have a personal mobile phone, an application will be installed on the primary caregiver&amp;#39;s phone), Having a digital literacy scale score over 17, Patients who agree to participate in the research will be included in the research.  Exclusion Criteria:  Patients diagnosed with acute renal failure Having vision problems - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Automated Screening for Clinically Ascertained Loss of Cerebral Functions
Status: Not yet recruiting

Rationale: The low organ donation rate in Germany is associated with the inadequate identification of patients at risk of developing irreversible loss of brain function (ILBF; i.e. brain death). An automated digital screening tool, DETECT (AutomateD ScrEening for Clinically AscerTainEd Loss of Cerebral FuncTions in Patients with Severe Brain Damage), has been developed to prospectively identify intensive care patients who are at risk of developing ILBF.

Objective: The objective of the study is to evaluate the effectiveness of an automated digital screening tool in the identification of patients with severe brain damage who are at risk of impending ILBF compared to standard practice without digital support.

Study design: Stepped-Wedge, multicenter, cluster-randomized, controlled trial

Study population: The study includes patients aged 18 years or older with primary and/or secondary acute brain damage, requiring mechanical ventilation, and who are deceased upon hospital discharge.

Intervention: DETECT periodically processes real-time data from the corresponding electronic medical record system to screen for a combination of coma, indicated by a Richmond Agitation Sedation Scale (RASS) score of - 4 or - 5 or Glasgow Coma Scale (GCS) score of 6-3, along with manually assessed absence of bilateral pupillary light reflexes. Both findings are considered early indicators of impending ILBF. In case of positive screening results, an automated notification will be sent via the hospital's email server to the corresponding transplant coordinators and intensivists. The email sent aims to prompt clinical assessment of the reported patient and, if necessary, initiate a guideline-based ILBF examination.

Primary study endpoint: The primary endpoint is the identification of patients who eventually develop ILBF during hospitalization.

Secondary study endpoints: Secondary outcomes encompass the missed identification of potential ILBF cases (as retrospectively classified) and the rate of deceased organ donations. Upon completion of the study, a survey will be conducted to investigate the stakeholders' experiences with DETECT.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Primary and/or secondary acute brain damage At least 18 years or older Necessity of mechanical ventilation Deceased upon hospital discharge  Exclusion Criteria:  • none - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
the 95% Effective Dose of Ciprofol for Adjunctive Sedation Undergoing Knee Arthroplasty in Elderly People
Status: Recruiting

Regional anesthesia is a common clinical anesthesia method, and regional anesthesia-assisted sedation play a central role in promoting patient comfort and relieving anxiety. With increasing age, elderly people experience changes in pharmacokinetics and pharmacodynamics and increased drug sensitivity. Ciprofol has advantages in adverse events such as hypotension and respiratory depression. There are fewer studies on the recommended dosage of ciprofol-assisted sedation for intrathecal anesthesia in elderly patients. The aim of study is to identify the 95% effective dose of ciprofol-assisted sedation in elderly patients undergoing spinal anesthesia using a biased coin design up-and-down sequential method(BCD-UDM)

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age ≥ 65 years ASA grade I~III BMI 18~28 kg/m2  Exclusion Criteria:  Contraindications to intrathecal anesthesia Suffering from severe psychiatric or neurologic disorders or taking sedative drugs within the last 3 months Difficult airway or having respiratory diseases such as upper airway obstruction Severe cardiovascular system diseases Severe hepatic or renal dysfunction Allergy or contraindication to propofol and its drug-related components Patient Prefusal - HealthyVolunteers: No - Gender: All - MinimumAge: 65 Years - StdAgeList: Older Adult
The Effects of Ischemic Conditioning in Individuals With Parkinson's Disease
Status: Not yet recruiting

Ischemic conditioning (IC) is a promising therapy that can mimic the physiological effects of physical exercise. IC consists of using a cuff to measure blood pressure and calibrate 200 mmHg on the upper or lower limb. Thus, at alternating intervals of 5 minutes, ischemia or reperfusion occurs, depending on whether the cuff is inflated or deflated. IC induces changes in spinal cord excitability for the last reflex reactions of recruited motoneurons with improved balance control in healthy young people and improved learning in the elderly. The objective of the present study is to evaluate the chronic effect of IC on the motor function and cognitive performance of patients with Parkinson's disease. Furthermore, the investigators will evaluate secondary outcomes such as mobility, quality of life, and immunological responses.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  PD patients aged 40 years or older; Diagnosis of PD without cognitive complaints or with complaints, but without impact on daily activities;  Exclusion Criteria:  Patients with uncontrolled diabetes mellitus or peripheral neuropathy; Uncontrolled arterial hypertension (BP>160/100mmHg); Uncontrolled diabetes (Fasting glucose > 250mg/dl, peripheral retinopathy or diabetic ketoacidosis); Uncontrolled dyslipidemia (total chol > 220mg/dL); Pre-existing autoimmune diseases; Infectious conditions for less than 1 month; Neurological problems that prevent training from being carried out; History of anemia, cerebral vascular disease, myocardial infarction in the last 6 months; Previous deep vein thrombosis; Smoking < 6 months; Symptomatic peripheral arterial obstructive disease; Cognitive dysfunction: Moca < 24. - HealthyVolunteers: No - Gender: All - MinimumAge: 40 Years - MaximumAge: 90 Years - StdAgeList: Adult, Older Adult
The Effect of Hybrid Telerehabilitation-Based Structured Exercise Programs in Patients With Multiple Sclerosis
Status: Recruiting

The aim of our study is to compare the effects of hybrid telerehabilitation (TR)-based exercise program applied in patients with MS, only TR-based exercise program and only clinical-based exercise program on walking speed, functional capacity, peripheral muscle saturation and fatigue. Forty-five individuals with MS with EDSS scores between 0-4 will be included in the study. The patients will be randomized into three groups: Group A, Group B, and Group C. Group A- Telerehabilitation group will be included in an aerobic and strengthening exercise program over the synchronized videoconference system with the physiotherapist 2 days a week for 8 weeks. Group B- Hybrid Telerehabilitation group will be included in the same exercise program 2 days a week for 2 weeks in the clinic, and will continue remotely over the synchronized videoconference system with the physiotherapist 2 days a week for 6 weeks. In Group C-Clinical Based Rehabilitation group, the same exercise program will be applied in the clinic 2 days a week for 8 weeks. In addition to aerobic and strengthening exercises, traditional breathing exercises and energy conservation techniques will be taught to all three groups within the scope of patient education Demographic and clinical information of all patients to be included in the study will be recorded with a "Case Evaluation Form". The gait speed of the patients will be evaluated with the Timed 25-step walking test, their functional capacity with the 6-minute walking test, their Quadriceps muscle activation will be tested with the EMG muscle activation, the fatigue will be evaluated with the "Modified Fatigue Impact Scale", and the Patient Satisfaction with the "Global Rating Scale". In addition, feasibility evaluation will be made by calculating the attendance rate of the patients to the programs. All data will be evaluated by statistical analysis methods.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  EDSS score of 0 - 4.0 Having high-speed internet access via smartphone or computer Getting at least 24 points from the Mini Mental Test Being at Stage 3 or above according to the Functional Ambulation Scale.  Exclusion Criteria:  Having hearing or vision problems. Participating in any exercise program. Having other accompanying neurological, cardiovascular or orthopedic disorders A history of MS attacks or a change in medication in the last 6 months. Being in a physical condition that cannot do the exercises. Comorbid conditions that negatively affect oxygen transport (severe anemia, peripheral artery diseases, etc.) - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult
Vaporized Cannabis Administration and Co-Administration of Alcohol on Impairment
Status: Not yet recruiting

This human laboratory study will use cognitive, behavioral, and subjective measures to characterize impairment associated with co-use of alcohol and vaporized cannabis. Participants (n=32) will complete 7 double-blind, double-dummy outpatient sessions in randomized order. In each session, participants will self-administer placebo (0 mg THC) or active vaporized cannabis (5 or 25 mg THC, via a handheld vaporizer called the Mighty Medic) and a placebo drink (BAC 0.0%) or alcohol drink calculated to produce a breath alcohol concentration (BAC) of 0.05%. Participants will also complete a positive control session in which the participant administers placebo cannabis and alcohol at a target BAC of 0.08% (the legal threshold for driving impairment in most U.S. states).

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Have provided written informed consent Be at least 21 years of age Be in good general health based on a physical examination, medical history, vital signs, and screening urine and blood tests Not be pregnant or nursing (if female). All females must have a negative serum pregnancy test at the screening visit and a negative urine pregnancy test at each study visit Have not donated blood in the prior 30 days Report at least 1 day of binge drinking in the past 3 months (greater than 4 or 5 drinks on a single occasion for women and men, respectively) Report at least 1 use of cannabis in the past 3 years Provide negative urine test for illicit drug use (excluding THC) and negative breath alcohol test (0% BAC) at screening and before study sessions Report at least 1 lifetime instance of simultaneous alcohol and cannabis use Current concomitant prescription medication use that may interact with the investigational study drug, including inhibitors and inducers of CYP2CP and CYP3A4 as well as highly-protein bound drugs and drugs with a narrow therapeutic index such as warfarin, cyclosporine, and amphotericin B  Exclusion Criteria:  Psychoactive drug use (aside from cannabis, nicotine, alcohol, or caffeine) in the past month History of or current evidence of significant medical condition that would put the participant at risk Evidence of current psychiatric condition (MINI for DSM-V) Meet criteria for severe alcohol use disorder (MINI for DSM-V) CIWA-Ar score > 9 Use of cannabis, on average, more than 3 days/week over past 3 months Enrollment in another clinical trial or receiving of any drug as part of research within past 30 days Shipley vocabulary score <18 (corresponds to 5th grade reading level) - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 21 Years - StdAgeList: Adult, Older Adult
Cross-Cultural Adaptation, Validity and Reliability of the Turkish Version of the ADAP Shoulder Scale
Status: Recruiting

Shoulder pain is a common musculoskeletal problem that increases disability and decreases quality of life in addition to socio-economic impact. Chronic pain is defined as pain lasting longer than 3 months. Chronic pain is a multidimensional and complex experience. According to this model, chronic pain is a multidimensional and complex experience. This experience may be accompanied by different pain beliefs, pain avoidance behaviours, pain-related fear of movement, anxiety and depression. Many conditions involving the shoulder complex including traumatic and non-traumatic pain, subacromial impingement, postoperative pain, rotator sheath tears, rotator sheath tendinopathy, shoulder arthritis, adhesive capsulitis, shoulder instabilities may lead to pain-related fear of movement.

Until now, pain-related fear and avoidance behaviours in patients with shoulder pain have been evaluated with the Tampa Kinesiophobia Scale, Pain Avoidance Beliefs Scale and Fear of Pain Scale. However, only patients with low back pain were included in the development of these scales. There was no scale developed specifically for shoulder pain. To fill this gap in the literature, Ansanello et al. developed the "Avoidance Daily Activities Photo Scale for Patients With Shoulder Pain (ADAP)" scale to evaluate pain avoidance behaviours in individuals with shoulder pain. Cross-cultural adaptation, validity and reliability of the Turkish version of the ADAP scale has not been studied.

The aim of our study was to perform cross-cultural adaptation, validity and reliability of the Turkish version of the Avoidance of Daily Activities Photo Scale for Patients with Shoulder Pain (ADAP Shoulder Scale).

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients with shoulder pain who have had pain for at least three months and who are between the ages of 18 and 64.  Exclusion Criteria:  Having rheumatological, neurological or musculoskeletal diseases, non-invasive interventions performed in the last 3 months, active infections, history of cancer, conditions requiring post-traumatic surgery. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 64 Years - StdAgeList: Adult - StudyPopulation: Patients with shoulder pain were included in the study. Patients with shoulder pain, pain for at least three months and aged between 18 and 64 years, and for the re-test only participants with unchanged health status were included in the study. Patients with rheumatological, neurological or musculoskeletal diseases, invasive intervention in the last 3 months, active infection, history of cancer, post-traumatic condition requiring surgery were excluded. - SamplingMethod: Probability Sample
Predictive Factors for Medullary Thyroid Cancer Aggressiveness
Status: Not yet recruiting

This study is a retrospective study trying to find the predictive factors for medullary thyroid aggressiveness in terms of tumor metastasis and patients' survival.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients who underwent thyroidectomy for medullary thyroid cancer (total thyroidectomy, completion thyroidectomy) +/- central/lateral neck dissection  Exclusion Criteria:  Age < 18 years - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: All patients >18 years old who underwent surgery for medullary thyroid cancer are enrolled in this study - SamplingMethod: Non-Probability Sample
Exercise for Improving Radiotherapy Efficacy in Rectal Cancer
Status: Not yet recruiting

This is a single arm feasibility study of exercise for improving short- course neoadjuvant radiotherapy efficacy in people diagnosed with locally advanced rectal cancer. The study aims to recruit up to 30 patients from the Queen's Centre for Oncology and Haematology of Castle Hill Hospital, Cottingham, diagnosed with locally advanced rectal cancer. Consenting patient's will be provided with a 7 weeks course of structured aerobic exercises and resistance training in the periods before, during and after their radiotherapy treatment. The patients will be followed up for 6 months post short course neoadjuvant radiotherapy, with a total of 3 assessment periods.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  18 years or older Have been diagnosed with locally advanced rectal cancer using MRI (Magnetic Resonance Imaging) and histological finding, Have been offered short-course neoadjuvant radiotherapy in the Queens Centre, Castle Hill Hospital Willing and able to comply with all study requirements Able and willing to voluntarily give informed consent to take part.  Exclusion Criteria:  Inability to understand basic written and spoken English, as research materials will all be written in English. Any movement deficiencies limiting ability to engage in exercise. Impaired cognition and/or capacity limiting ability to provide informed consent. Cardiovascular and/or cardiopulmonary conditions that will impede ability to safely perform exercise. Severe psychiatric disorders. With any other health condition which oncologists and research team agrees will impede ability to safely perform exercises. Presence of metastatic cancer. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Clinical Study of Resistant Starch in Improving Constipation
Status: Recruiting

Constipation is one of the most common gastrointestinal (GI) disorders in clinical practice, with approximately 11-20% of adults worldwide suffering from constipation. Clinically, the frequency of defecation is reduced, or the defecation is laborious, obstructed, difficult, and the stool is dry and difficult to solve, which is called constipation. Clinically, constipation is difficult to treat and over-reliance on laxatives often leads to water and electrolyte imbalance, gastrointestinal dysfunction, melanosis of the colon, relaxation of anal sphincter and other problems, and even leads to colorectal cancer, diabetes, anorexia nervosa and other complications in some cases. Therefore, it is very important to find a safe and effective laxative drug or diet to improve and relieve constipation symptoms. The health promotion effect of resistant starch is mainly due to the short-chain fat and gas produced by microbial fermentation in the colon, and its role in preventing colorectal cancer and some diet-related chronic diseases is stronger than dietary fiber, and it can effectively overcome the adverse odor, rough texture, poor quality and other drawbacks of food fortified with dietary fiber. Ruminococcus bromii is a specific microorganism that degrades resistant starch. The starch decomposing enzyme of R. bromii has a unique tissue structure and forms a multi-enzyme complex. Through the adhesion protein and dockerin module, it is attached to the cell surface through the scaffold protein in the cellulose body. Big data analysis showed that the relative abundance of R. bromii in healthy people was significantly higher than that in patients with constipation. Therefore, the purpose of this clinical trial is to supplement resistant starch to patients with constipation: (1) Observe whether the symptoms of patients with constipation have improved; (2) Analyze the changes of intestinal microorganisms in patients with constipation; and (3) Verify whether the relative abundance of R. bromii is increased and analyze the correlation between the relative abundance of R. bromii in intestine and the improvement of constipation symptoms in patients with constipation.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  The clinical manifestation is constipation, which meets the diagnostic criteria of Roman IV constipation.  Exclusion Criteria:  Colonoscopy excludes patients with colorectal tumors within one or two years - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult