Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia Consortium
Status: Recruiting

Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia (MarkVCID) is an NIH-funded consortium dedicated to finding biomarkers involved in age-related thinking and memory problems. Alzheimer's disease and other dementias leave signatures on brain scans or in the blood called biomarkers. The MarkVCID study will measure a panel of candidate biomarkers in 1800 participants and watch them closely to see what they tell us about changes in brain function and risk of memory loss.

Age-related problems in thinking and memory represent some of the greatest risks to public health in the US and globally. Diseases that affect small blood vessels in the brain have been shown to be major contributors to these changes. However, research and patient care can be held back by limited biomarkers that identify who should be treated.

The MarkVCID Consortium includes 17 US medical centers, a Coordinating Center, an External Advisory Committee, and NIH leadership. Data and biospecimens collected as part of this research study will be stored in a research database and biorepositories, so that researchers can use this information to study brain function.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age ≥ 60 and ≤ 90 years Diagnosis of normal cognition with at least one criterion for vascular risk*, subjective cognitive decline (preliminary diagnosis based on self-report question or eCog-12), mild cognitive impairment, or mild dementia based on standard research criteria Fluent in English or Spanish No contraindications to MRI including CVR  No confounding neurologic, psychiatric, or medical disease  *Participants with normal cognition must meet at least one criterion (diabetes, OR hypertension plus, OR MRI factors) for vascular risk prior to enrollment:  Diabetes (at least one of the following):  Fasting (8-hour fast, usually overnight) blood sugar ≥126 mg/dL (≥7 mmol/L, or ≥1260 mg/L) Random or Post-prandial blood sugar ≥200 mg/dL (≥11.11 mmol/L, or ≥2000 mg/L) HbA1C ≥6.5% (or ≥47.5412 mmol/mol) Treatment with an anti-diabetic medicine  Hypertension plus (at least two of the following):  Use of anti-hypertensive medications for lowering blood pressure for ≥ 10 years Current use of two or more anti-hypertensive medications for lowering blood pressure One measured blood pressure in a research or clinical setting in the last 2 years with SBP ≥140 or DBP ≥90 A second measured blood pressure in a research or clinical setting on a different date in the last 2 years with SBP ≥140 or DBP ≥90 Evidence of likely HTN end-organ damage (e.g., LVH, albuminuria, eGFR<60, CHF)  MRI factors (at least one of the following):  Peri-Ventricular Fazekas Extent Grade or Deep Fazekas Extent Grade ≥ 2 1 or more microbleeds 1 or more lacunar infarcts  Exclusion Criteria:  Neurologic Disease: Based on the available data and investigator's impression, exclude those with confounding neurologic disease that would interfere with test performance or with biomarker analysis:  Frontotemporal lobar degeneration (FTLD) Lewy body dementia (LBD) Parkinson's disease Multi system atrophy Traumatic brain injury (TBI)-related cognitive impairment TBI that interferes with MRI biomarker analyses (e.g., large volume traumatic lesion) Non-small vessel strokes that interfere with test performance (e.g., post-stroke cognitive impairment or aphasia) Non-small vessel strokes that interfere with MRI biomarker analysis (e.g., large volume strokes) CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) Individuals known to be receiving, or planning to receive, anti-amyloid immunotherapy*  Other neurologic conditions that interfere with test performance or biomarker analysis  Individuals prescribed anti-amyloid immunotherapy after MarkVCID enrollment should be kept in the study.  Medical and Psychiatric Conditions: Exclude those with medical and psychiatric conditions that would confound the course or interfere with test performance:  Schizophrenia or other active/severe psychotic disorders Medical or psychiatric conditions likely to interfere with participation or retention (e.g., metastatic or malignant CNS cancer, active/severe depression or anxiety, HIV- Associated Neurocognitive Disorder)  Contraindications to MRI procedures, such as:  Claustrophobia Cardiac pacemaker Intracranial clips/metal implants  Contraindications to CVR:  COPD or other respiratory condition requiring oxygen therapy Asthma or other respiratory condition requiring current use of medications such as inhalers - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 60 Years - MaximumAge: 90 Years - StdAgeList: Adult, Older Adult - StudyPopulation: The study population will be selected from a variety of sources across the MarkVCID Consortium sites. These sources include, but are not limited to:  MarkVCID1 or other research studies Alzheimer's Disease Research Center database Patient registries such as Volunteer for Health Community centers or organizations  Clinics:  Primary care Neurology Stroke Center Outpatient Diabetes Memory & Aging - SamplingMethod: Non-Probability Sample