rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
Livelihoods Intervention With Urban Refugee Youth in Kampala, Uganda
Status: Recruiting

Displaced and refugee youth in Uganda are more vulnerable to health risks due to financial insecurity. As such, the investigators aim to explore the utility of an intervention aimed at improving livelihoods, called Creating Futures. Creating Futures is a group intervention that aims to help young people build their livelihoods, and was designed for use with youth (18-24) in urban informal settlements in South Africa.

Since there is a dearth of knowledge regarding efficacious interventions in refugee camps/settlements to engage young people in HIV testing and linkage to care, the investigators will harness various health promotion techniques including mHealth, comics, and the Creating Futures livelihoods intervention to address the urgent needs for: 1) HIV testing interventions with refugee/displaced adolescent and young people in Kampala, and 2) innovative HIV self test (HIVST) delivery strategies to increase linkage to confirmatory testing and HIV care. The investigators will conduct a three-arm cluster randomized controlled trial (cRCT) to evaluate the effectiveness of HIVST delivery methods among AYP living in Kampala. The specific objectives are to: Evaluate the feasibility and effectiveness of: 1) HIVST alone; 2) HIVST in combination with mHealth; and 3) HIVST, mHealth and Creating Futures in combination in increasing routine HIV testing, HIV status knowledge, and linkage to confirmatory testing and HIV care. The investigators aim to examine if adding a livelihoods program to HIV self-testing improves HIV prevention outcomes and other facets of well-being among urban refugee youth in Kampala.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Living in one of the five selected Kampala informal settlements (Kabalagala, Kansanga, Katwe, Nsambya, or Rubaga) Identify as a displaced person, refugee, or as having a refugee or displaced parent(s) Aged 16-25 years Own or have daily access to a mobile phone Speak French, English, Kirundi, Kinyarwanda, or Swahili  Exclusion Criteria:  Not living in one of the five selected informal settlements Does not identify as a displaced person, refugee, or as having a refugee or displaced parent(s) Aged 15 and under or 26 and older Does not have access to a mobile phone or shares a phone Does not speak one of French, English, Kirundi, Kinyarwanda, or Swahili - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 16 Years - MaximumAge: 25 Years - StdAgeList: Child, Adult
Timing of TAP Blocks in Bariatric Surgery
Status: Not yet recruiting

This clinical trial aims to determine the optimal timing for administering a Transversus Abdominis Plane (TAP) block in bariatric surgery, specifically investigating whether initiating TAP blocks at the beginning of surgery is more beneficial than at the end, which is the current practice. The study targets obese patients undergoing bariatric surgery, with a focus on reducing postoperative pain and opioid use. Key outcomes include recovery duration, pain levels, opioid consumption, and respiratory function. Successful results could establish early TAP block initiation as a standard practice, offering faster recovery, decreased opioid reliance, and reduced healthcare costs.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients undergoing primary bariatric surgery at St. Joseph's Healthcare Hamilton surgery including Sleeve Gastrectomy (SG) or Roux-en-Y Gastric Bypass Surgery (RYGB) Patients >18 Years of Age  Exclusion Criteria:  Patients undergoing a revisional bariatric surgery Patients with a history of chronic pain or opioid use. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Dial-Bicarb Trial: Effects of a Lower vs. Higher Concentration of Dialysate Bicarbonate
Status: Not yet recruiting

This is a pragmatic, two-arm, parallel-group, open-label, individual-randomized, superiority trial that will be conducted in hemodialysis units across Ontario. Patients at each dialysis unit will be randomly allocated into one of two study arms in a 1:1 ratio to receive a dialysate bicarbonate concentration of either 32 or 38 mmol/L. The intervention will be embedded into routine care and delivered by hemodialysis unit personnel.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  - Patients at participating dialysis units who have received hemodialysis for at least 90 days  Exclusion Criteria:  Patients on in-centre nocturnal hemodialysis or in-centre frequent (greater than four times weekly) hemodialysis - HealthyVolunteers: No - Gender: All - StdAgeList: Child, Adult, Older Adult
Development of a Healthcare Service Platform for Successful Aging
Status: Recruiting

The goal of this living-lab clinical trial is to test the effectiveness of digital health monitoring and feedback platform for community dwelling older adults. The main questions it aims to answer are:

Identify digital sensing variables that are predictive of mental and physical health declines and health emergencies of older adults
Develop digital health monitoring service to inform individualized daily health status of older adults users
Develop ICT network to share the daily health status and emergency signals with community based healthcare service providers and family caregivers if an older adult user approves of them to receive their health information.

Participants will be asked to participate in a living lab using a wearable sensor, motion sensor, and smartphone applications for 6 weeks and also take part in pre-mid-post surveys to evaluate the usability, accuracy, and effectiveness of the digital healthcare service platform to improve health managements and connections with community and family caregivers.

If there is a comparison group: Researchers will compare age and gender matched control group to see if health status of the living-lab group is better than the control group.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Community dwelling older adults who are 65 years old and older  Exclusion Criteria:  Older adults with cognitive, sensory, and functional problems that may hinder them from participating surveys. Older adults with iOS mobile device that would not allow them to use the developed mobile application. Older adults in nursing home or who are hospitalized because this platform is designed to support independent living of an older adults in their home. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 65 Years - StdAgeList: Older Adult
" Fume Events in Air Flights: Consequences on Cabin Air Quality and on Aircrews Health of a French Fleet of Aircraft"
Status: Not yet recruiting

The subject of the study focuses on commercial aircraft's cabins air quality, under conditions of both fume events and non-fume events. It also delves into the immediate and delayed repercussions of these events on the health of aviation crew members. The expological facet of this study is directed at the detection and quantification of organophosphorus compounds originating from engine oils. The epidemiological facet is geared towards the identification of potential neurological consequences.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  be of legal age (18 years) have signed the consent form  Exclusion Criteria:  be pregnant be over 67 years of age - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 67 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Healthy aircrew population of a French airline exposed with (exposed) and whithout (non-exposed) fume events. - SamplingMethod: Probability Sample
Responsiveness and Minimal Important Change of Two Measures of Pain Intensity in People With Low Back Pain
Status: Not yet recruiting

This is an observational study aimed at evaluating the responsiveness and minimal important change of two measures of pain intensity in people with low back pain. It consists of a battery of self-administered questionnaires which will be given to individuals with low back pain to complete before and after a rehabilitation treatment. Relationships among the different outcome measures will be also evaluated.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Non specific low back pain Adult age Ability to understand the Italian language  Exclusion Criteria:  Refuse to adhere to the study Definite causes of low back pain Central or peripheral neurological signs Systemic illness or psychiatric deficits Recent myocardial infarction, cerebrovascular events, or chronic lung or renal diseases - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 90 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Non-speciﬁc low back pain is deﬁned as low back pain not attributable to a recognizable, known speciﬁc pathology (eg, infection, tumour, osteoporosis, lumbar spine fracture, structural deformity, inﬂammatory disorder,radicular syndrome, or cauda equina syndrome). - SamplingMethod: Probability Sample
Evaluation of Telemedicine Medical Abortion Service in Ecuador
Status: Not yet recruiting

This research seeks to demonstrate that a telemedicine model for the provision of legal abortion services in Ecuador is safe, feasible and acceptable to users requesting a medication abortion and who are less than 12 weeks pregnant.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Woman is seeking abortion care and wants to use telemedicine service for her medication abortion procedure. Woman has access to an internet connection or a device that allows remote consultation. Woman is 15 years of age or older. Woman can provide an address to which abortion medications will be mailed. Woman reports having no contraindications to a medical abortion. The study provider does not suspect ectopic pregnancy or a nonviable pregnancy. The gestational age allows sufficient time for the woman to take the misoprostol no later than 84 days of gestation. A feasible plan is made that the woman agrees to confirm complete abortion and to seek care to manage incomplete abortion complications. The woman understands the study procedures and is likely to comply with study instructions and has granted informed consent to participate in the study.  Exclusion Criteria:  Medically ineligible for procedure. Provider determines that a medical abortion using the telemedicine approach is not appropriate for that person. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - MinimumAge: 15 Years - StdAgeList: Child, Adult, Older Adult - StudyPopulation: Women seeking abortion - SamplingMethod: Non-Probability Sample
Focal Therapy for Localized Prostate Cancer
Status: Recruiting

This prospective registry and longitudinal study that is designed to carefully measure details of prostate cancer patients' outcomes with focal therapy. The goal of which is to improve patient care.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Subject has elected or already undergone focal therapy as their standard of care treatment method and declined alternative treatment (active surveillance, radical prostatectomy, and radiation therapy) PSA ≤ 20 Ability to complete informed consent form  Exclusion Criteria:  Contraindication to follow-up multi parametric MRI or prostate biopsy Unable to tolerate general or regional anesthesia - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Male - GenderBased: Yes - GenderDescription: Male - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Subjects who have biopsy-proven adenocarcinoma of the prostate, who have met all study inclusion and exclusion criteria, and have elected to receive or have already received the focal therapy as part of their routine prostate cancer treatment, will be invited to participate in this observational registry study. - SamplingMethod: Non-Probability Sample
Safety, Tolerability and Pharmacokinetics of LNZ101 and LNZ100 Ophthalmic Solutions in Healthy Adult Chinese With Presbyopia
Status: Not yet recruiting

Phase I Clinical Study to Evaluate the Safety, Tolerability and Pharmacokinetics of LNZ101 and LNZ100 Ophthalmic Solutions in Chinese Healthy Adult Subjects with Presbyopia

Eligibility:
- EligibilityCriteria: Inclusion Criteria  Be able and willing to provide written informed consent prior to any study procedure being performed. Be able to and willing to use investigational products per study requirements and attend all study assessments, including admission to and stay in the CRU on required study days. Be Chinese healthy male or female subjects aged 45-75 years (inclusive) at screening. Be diagnosed and documented to have presbyopia by the investigator at the screening visit.  Exclusion Criteria:  Have known contraindications or sensitivity to the use of any of the investigational products or its components, or any other medications required by the protocol. Have any active systemic or ocular disorder that has a potential risk to or impact on subject safety, study process or study results other than refractive disorder. Have presence of any abnormality of the lids, ocular surface, or lacrimal duct system that in the investigator's opinion could affect ophthalmic solution absorption in either eye. Have prior (within 14 days of the first dose), current or anticipated use of any contact lenses during study participation. Be ineligible for this trial in the opinion of the investigator. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 45 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult
Evaluation of Metastatic Disease and Oncological Treatment in Patients With Colon Cancer Using Zebra Fish Avatars
Status: Recruiting

In order to improve and individualize cancer treatment personalized treatments developed much further. Colon cancer is treated with surgery and thereafter adjuvant oncological treatment. The selection of chemotherapy is today mainly done according to best guess. Today only a small fraction of oncological treatment may be known to be effective in a person before treatment start, most often it is trial and error. A fast reliable system for looking at response to different treatments in each unique patient is much needed and would, if successful, completely change the way we give oncological treatment today. This system would also be possible to use to evaluate new treatments and if successful, implement in the clinical setting. In this project we will implant a part of the patient's tumour tissue into a zebrafish embryo and evaluate tumour growth and frequency of metastatic disease as well as response to given oncological treatment.

2.2 Objective: The objective of this project is to explore the usefulness of zebrafish (Danio Rerio) embryo models to determine tumor biology and treatment response in colon cancer. An overarching goal would be, before start of any oncological treatment in a patient, to have evaluated the response of oncological treatment in the zebrafish avatar and only treat with a combination of drugs known to have effect against the patient's own tumour.

2.3 Study design: This protocol describes a series of prospective studies in different cohorts of patients with colon cancer to investigate the applicability of zebrafish embryo models. The common denominator of the sub-studies is prospective collection of tumor tissue implanted in zebrafish embryos in order to evaluate if the model is robust enough for growing colon cancer tissue and evaluate growth pattern and response to chemotherapy. This study protocol is designed according to and in adherence with the SPIRIT guidelines.

2.4 Intervention: In all sub-studies the intervention is inoculation of tumor cells in zebrafish embryos followed by observation of tumor behavior and testing of treatments.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Colon cancer planned for radical colon resection signed informed consent  Exclusion Criteria:  Not willing to participate - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Effect of Nonsurgical Periodontal Therapy on Salivary Biomarkers Related to Bone Turnover in Smoker and Nonsmoker Periodontitis Patients
Status: Not yet recruiting

To assess the alteration in the level of salivary osteopontin (OPN), osteonectin(ON) and histatin-1 following NSPT in smoker and nonsmoker unstable periodontitis patients at different time intervals(one month and three months) .
To evaluate the response of clinical periodontal parameters ( plaque index ,bleeding on probing ,probing pocket depth ,clinical attachment loss)following NSPT in smoker and nonsmoker unstable periodontitis patients at different time intervals (one month and three months)

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  participants will be systemically healthy without history of any systemic diseases. hadn't underwent periodontal treatment during the previous 6 months and not taken medication during the previous 3 months. present with at least 20 teeth, those who only diagnosed with 4-6 mm probing pocket depth, generalized ,unstable periodontitis who had bone loss > 30% , probing probing pocket depth at ≥4mm . Periodontitis cases were defined if clinical attachment loss was detected at ≥2 non- adjacent teeth or when buccal (facial) showed clinical attachment loss ≥3mm associated with probing pocket depth >3mm at ≥ 2 teeth . The patients in the smokers group will be current smokers ( cigarette smokers) with smoking habit for over 3 years  Exclusion Criteria:  Subjects have any intraoral plaque retentive factors such as those wearing partial denture, crown and bridges, and orthodontic appliances ,furcation involved teeth, overhang filling, tooth anomaly. receiving antibiotic therapy during the previous 3 months. those with systemic diseases such as diabetes mellitus, cardiovascular or renal diseases, etc…., pregnant or lactating women, not willing to participate or continue to conduct the study. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - StdAgeList: Child, Adult, Older Adult
Fascial Anthropometry in Archery Athletes
Status: Not yet recruiting

In archery, the body morphological and anthropometric characteristics of the prominent athletes change. It is important to examine facial anthropometry, especially since the athlete's equipment touches the facial area, and there are no studies on this subject. The aim of this study is to determine the relationship between facial anthropometric measurements and anthropometry-related parameters and sports performance in archery athletes.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Being between the ages of 9-18 years. Having been practicing archery at least twice a week for at least 2 years. Not having changed the bow category since it started. Fonseca Anamnestic Questionnaire result is between 0-15 points volunteering to participate in the study  Exclusion Criteria:  Having had surgery involving the spine and upper extremities in the last year Scoliosis being diagnosed Having an orthopedic, neurological or musculoskeletal disease that involves the upper extremity and prevents shooting Having received orthodontic treatment orthodontic surgery to have had Being actively involved in another sports branch for at least 1 year - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 9 Years - MaximumAge: 18 Years - StdAgeList: Child, Adult - StudyPopulation: being archer at least two years. - SamplingMethod: Probability Sample
Assessment of Collagen Membrane Interest in Distal Cuff Lesions Repair
Status: Not yet recruiting

Rotator cuff refers to a set of 4 shoulder tendons. These tendons are the sub-scapularis, supra-spinatus, infra-spinatus and teres minor. Rotator cuff tear corresponds to total or partial tendon disinsertion at the greater tuberosity level or a few centimeters in upstream.

Rotator cuff surgery is an increasingly popular procedure practiced in France. In limited cuff lesions (distal or intermediates) and in absence of contraindication, absence of tendons' healing is around 10 to 20%. Sofcot estimates that 90% of caps' heals remain healed 10 years after surgery in distal lesions. However, even in case of a healed cuff, if tendon quality is not good, function will be impaired.

Bioinductive implant Regeneten® is an advanced healing solution for biological improvement and regeneration of tendons on all types rotator cuff tear. A randomized study was initiated whose main objective was to evaluate integrity of repaired tendon with MRI one year after intervention according to Sugaya's classification. Results showed a recurrence rate of 8.3% in Regeneten® group compared to 25.8% in witness group.

In this context, this study is based on hypothesis that adding Regeneten® during rotator cuff repair could be beneficial on tendon healing rate but also on tendon quality healing.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patient, male or female, aged ≥ 18 years Patient candidate for rotator cuff repair affecting supraspinatus tendon (distal lesion) +/- infraspinatus on a non-pseudo-paralytic shoulder +/- proximal lesion of subscapularis Patient with GI ≤ 2 for each muscle Non-smoking patient Patient who is not involved in a work accident Patient candidate for total rotator cuff repair completely covering the footprint during surgery  Exclusion Criteria:  Patient with contraindication to MRI Patient operated for cuff revision - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Theory-Driven Manualized Approach to Improving New Learning and Memory in Healthy Aging and MCI
Status: Not yet recruiting

The purpose of this research study is to investigate the effectiveness of a memory enhancement technique in an aging population.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Inclusion Criteria:  read and speak English fluently  Exclusion Criteria:  prior stroke or neurological injury/disease (i.e. traumatic brain injury, Multiple Sclerosis, or Stroke). history of significant psychiatric illness (for example, bipolar disorder, schizophrenia, or psychosis). significant alcohol or drug abuse history (inpatient treatment). Benzodiazepines and steroid use Diagnosis of dementia - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 60 Years - StdAgeList: Adult, Older Adult
Cognitive Behavioral Therapy for Chronic Pain in Adults With Cerebral Palsy
Status: Not yet recruiting

The purpose of this study is to understand if cognitive behavioral therapy can improve pain-related thought patterns and pain-related impairment in adults with cerebral palsy.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  At least 18 years of age Diagnosis of cerebral palsy Reports that pain at least "somewhat" interfered with at least one aspect of life in the past 7 days Clinically elevated Pain Catastrophizing Scale (PCS) score Endorses the ability and willingness to participate in all assessment and group sessions regardless of randomization outcome Shows developmental readiness to benefit from CBT via the Behavior, Thought, Feeling Questionnaire (BTFQ)  Exclusion Criteria: (if met then participant will not eligible to participate)  1. Previously received Cognitive Behavioral Therapy (CBT) for chronic pain - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult