rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
Interactive Telehealth Intervention to Increase Longitudinal Adherence to Repeat Faecal Immunochemical Test Screening
Status: Not yet recruiting

In Hong Kong, Colorectal cancer ranks second in both cancer incidence and mortality. The government-subsidized population-based CRC screening program (the Program) was launched for asymptomatic individuals aged 50-75 years to undergo biennial FIT screenings. A subsidized follow-up colonoscopy is offered to participants with positive FIT results. Participants are advised to repeat the FIT screening 2 years after receiving a negative result. An automated noninteractive short message service (SMS) text reminder, used by the Program as standard care (SC), is delivered to participants who are due for repeat FIT. According to unpublished data, despite SC, only 34% of participants adhere to biennial repeat FIT in the CRC screening program. Nonadherence to repeat FIT screening is caused by forgetfulness and is associated with an individual's psychological health behaviour.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  50-75 years old already enrolled in the Program with negative FIT results in 2022 eligible for the Program inclusion and due for repeat FIT screening in 2024 either the participants themselves or their family members / caregivers have access to and agree to be contacted via WhatsApp ability to understand Chinese  Exclusion Criteria:  who have incomplete conversations with the chatbot, lack of access to WhatsApp, or are unable to provide informed consent will be excluded - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 50 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult
The Role of Intermediaries in Connecting Individuals to Local Physical Activity - Study Protocol
Status: Recruiting

Intermediaries help people to connect to community-based services and supports, including physical activity and exercise groups (physical activities). They do this by acting as a link person. After receiving a referral or self-referral, they conduct an assessment, connect people to services in the community, and follow-up with people over time.

This project will investigate if connecting to physical activities through an intermediary can improve health and wellbeing. It will also investigate people's experiences of working with an intermediary. This project is a pilot feasibility study, which means the investigators are evaluating the measures used and the way the trial is designed to see if they are suitable for a larger study in the future.

Eligibility:
- EligibilityCriteria: Inclusion criteria  Aged ≥18 years Referred to intermediary service for any reason OR self-referred to intermediary service for any reason Meets the eligibility criteria of the intermediary service Intermediary facilitates a connection to local physical activity  Exclusion criteria  Non-community dwelling e.g., hospital in-patients, living in residential care facilities Diagnosis of dementia Inappropriate for health or social reasons (such as terminal illness, family or other social crisis) Refused to engage with the intermediary service Unable to give explicit informed consent - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - StdAgeList: Child, Adult, Older Adult - StudyPopulation: Participants are adults aged >18 years old, able to give explicit informed consent, referred to an intermediary and that the intermediary plans to connect to local physical activities. - SamplingMethod: Non-Probability Sample
Cognitive Disorders in Hereditary Spastic Paraplegia Type 4
Status: Recruiting

Hereditary spastic paraplegia type 4 is the most frequent mutation of hereditary spastic paraplegias. It is commonly described as pure, with progressive weakness of the lower limbs, pyramidal syndrome and vesico-sphincter disorders. However, cognitive disorders have been reported for over 20 years, but remain poorly characterized.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patient over 18 years of age, living in the Grand Est region (France) Patient with a pathogenic or probably pathogenic variant (class 4 or 5) in the SPAST gene.  Exclusion Criteria:  dementia comorbidities or cognitive disorders unrelated to the pathology that may affect neuropsychological tests. - HealthyVolunteers: No - Gender: All - StdAgeList: Child, Adult, Older Adult - StudyPopulation: Patients followed in the Grand Est region for type 4 spastic paraplegia with identification of a pathogenic or probably pathogenic variant in the SPAST gene. - SamplingMethod: Non-Probability Sample
Endovascular Treatment of Acute Ischemic Stroke With Underlying Intracranial Artery Stenosis
Status: Recruiting

The study is a prospective multicentre registry study. Patients admitted to 10 stroke centres nationwide from September 2022 to September 2025 with acute ischaemic stroke due to large vessel occlusion considering underlying ICAS and treated with emergency endovascular thrombolysis were included for analysis. Patients who met the general inclusion criteria underwent thrombectomy and the necessary remedial treatment.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  CT scan to exclude intracranial haemorrhage；CT angiography (CTA), magnetic resonance angiography (MRA) or digital subtraction angiography showing occlusion of the distal intracranial carotid artery or the first segment of the middle cerebral artery；ELVO with a base ICAS of > 70%；Mechanical thrombectomy within 6h after symptom onset in ischemic stroke；NIHSS≥6；receiving endovascular treatments；informed consent form signed by the patient or their legal representatives.  Exclusion Criteria:  Hemorrhagic body, coagulation factor deficiency or oral anticoagulant therapy(INR > 3.0)；Baseline platelet count <50,000/µL；Baseline blood glucose <50mg/dL or >400mg/dL；Intractable hypertension(systolic blood pressure >220 mmHg or diastolic blood pressure >110 mmHg) that cannot be controlled by medication；Patients intubated without a NIHSS score assessed by a neurologist or emergency physician prior to intubation；Stroke attack with epilepsy affecting baseline NIHSS score；End-stage diseases leading to less than one year of expected survival for patients；Severe allergy to contrast media；Patients with renal insufficiency (blood creatinine ≥ 3 mg/dL)；Female patients who are pregnant or breastfeeding；The patient is participating in other drugs or device studies that may affect this study；Patient with cerebral vasculitis - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Patients with acute cerebral infarction with underlying intracranial artery stenosis receiving endovascular treatment - SamplingMethod: Non-Probability Sample
Expecting Mother's Study of Consumption or Avoidance of Peanut and Egg
Status: Not yet recruiting

Peanut allergy is the most common cause of fatal and near-fatal food-allergic reactions and egg allergy is among the two most common causes of food-induced anaphylaxis. The proposed research will explore the development of sensitization to these food(s) in infants based on maternal consumption or avoidance during pregnancy and breastfeeding.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Participant must be able to understand and provide informed consent Parental permission must be provided for infants Adults, 18 years and older and their child Pregnant women in first or second trimester, carrying a fetus with a first-degree relative with any self- reported or physician-diagnosed allergic disease (asthma, allergic rhinitis, atopic eczema or food allergy) Intention to breastfeed more than 3 months Must have history of eating peanut and egg and have tolerated consumption with no food allergy reactions Willing to be randomized to consumption or avoidance diet  Exclusion Criteria:  Inability or unwillingness of a participant to give written informed consent or comply with study protocol. Chronic infection or inflammatory disease such as cystic fibrosis or inflammatory arthritis. Renal/liver/cardiac insufficiency. Mothers with peanut or egg allergy. Mothers who refuse to eat peanut (or peanut products) and/or eggs (or products containing eggs) . Known immunodeficiency. Current, diagnosed, mental illness or current, diagnosed, or self-reported, drug or alcohol abuse that, in the opinion of the investigator, would interfere with the participant's ability to comply with study requirements. Past or current medical problems or findings from physical examination or laboratory testing that are not listed above, which, in the opinion of the investigator, may pose additional risks to the mother or infant from participation in the study, may interfere with the participant's ability to comply with study requirements or that may impact the quality or interpretation of the data obtained from the study. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - GenderBased: Yes - GenderDescription: To understand the mechanisms whereby maternal diet either positively or negatively affects the development of their infant from the womb through the first few months of life, it is necessary to recruit healthy pregnant women. - MinimumAge: 18 Years - MaximumAge: 40 Years - StdAgeList: Adult
Targeted Navigation in Hepatocellular Carcinoma (HCC)
Status: Not yet recruiting

The investigators are trying to learn more about the personal perceptions and experiences regarding the needs of patients with liver cancer to help improve the care of all patients. The investigators would like to know whether there are needs that patients have or are aware of, especially those needs that the investigators have not been able to address. The investigators aim to develop a program that helps participants and participant's families to navigate the process of being diagnosed with liver cancer and receiving treatment.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  HCC Patients:  Enrolled or eligible for enrollment in Unified Prospective Registry and Biorepository of Patients with Chronic Liver Disease or Hepatobiliary Cancers Including Hepatocellular Carcinoma (HCC) and Cholangiocarcinoma. Diagnosis of hepatocellular carcinoma, confirmed by clinical chart review and International Classification of Diseases, Tenth Revision (ICD-10) C22.0. Adults, age 18 or older Able to provide informed consent  All other interviewees:  Advocates who will self-identify as having had HCC. Others who self-identify as either a caregiver or support person of an HCC patient.  Physicians/Licensed Independent Practitioners, Social Workers, Nurse Navigators, and Research Coordinators will all self-identify as being involved in the care of HCC patients.  Exclusion Criteria:  Unable to speak Spanish or English West Haven Grade 2 or higher hepatic encephalopathy19 or other cognitive impairment. Adults unable or unwilling to consent Individuals who are not yet adults (infants, children, teenagers) Prisoners Given that this study is minimal risk and there are no risks to a potential fetus, investigators will not exclude pregnant women; however, no data about pregnancy or their fetus is being collected - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Zinc Supplementation in Sickle Cell Disease
Status: Not yet recruiting

The goal of this short term prospective Phase II study is to compare the effects of two alternate daily doses of zinc (25 and 40 mg/day) in 34 randomly assigned homozygous Sickle Cell Disease (SCD-SS) patients aged 15-35 years old. The main question it aims to answer is: Which biomarkers are most responsive to zinc supplementation, and what is the maximum tolerated zinc dose that induces the desired changes in biomarkers of bone turnover? Participants will be recruited from 7 American Society Hematology Research Collaborative SCD Centers. Eligible SCD subjects will be invited to participate in the 16-week study, involving 2 baseline blood draws 4 weeks apart, followed by a 12-week zinc intervention. The findings from this study will be used to determine the dosage of zinc to be used in a larger, future study on the long term impact of zinc supplementation on bone health in SCD-SS.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age: ≥ 15.0 to ≤ 35.0 years Diagnosis: SCD-SS, in steady state (defined as a minimum of 10 days following pain crisis) Male or Female (n=17 of each) stratified by age group (15-25 ; 25-35 years)  Exclusion Criteria:  Taking zinc supplements and unable/willing to stop for 3 months prior to study start On chronic transfusion therapy (defined as >8 Transfusions/year) Unable swallow pills or take daily supplement as instructed Renal dysfunction (defined as creatinine > 1.5 mg/dL or estimated glomerular filtration rate < 60) - HealthyVolunteers: No - Gender: All - MinimumAge: 15 Years - MaximumAge: 35 Years - StdAgeList: Child, Adult
Short-term Intravenous Fluids for Prevention of Post-ERCP Pancreatitis
Status: Not yet recruiting

This study will explore the efficacies of several practical short-term (peri-procedural) intravenous fluid regimens in the prevention of post- endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). PEP is the most common serious ERCP-related adverse event (AE), occurring in 5-15% of patients, and associated with significant morbidity, mortality, and healthcare utilization. Given the current lack of data on effectiveness of short-term fluid regimens in PEP prevention to inform practice, the results of the proposed study have the strong potential to impact ERCP practices worldwide, whether positive or negative.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  age 18-75 years (due to higher likelihood of undiagnosed cardiac disease or renal insufficiency in patients >75 years of age) ability to give informed consent native major papillary anatomy ability and willingness to obtain bloodwork the day after ERCP  Exclusion Criteria:  prior ERCP with sphincterotomy and/or sphincteroplasty confirmed or suspected cholangitis or sepsis confirmed pancreatitis, hyperlipasemia, or hyperamylasemia within the preceding 7 days NYHA Class II or greater heart failure active pulmonary edema myocardial infarction or ischemia within the preceding 3 months renal insufficiency with CrCl < 40 mL/minute CPT Class B or C cirrhosis and/or end-stage liver disease room air oxygen saturation <90% or requirement of home O2 hypernatremia with Na+ ≥ 150 mEq/L or Na+ <130 mEq/L uncontrolled hypertension or hypotension pregnant status - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult
A Confirmatory Trial of Multidisciplinary Digital Therapeutics for Patellofemoral Pain Syndrome
Status: Not yet recruiting

This randomized controlled confirmatory study will be evaluating an mobile application, MORA Cure (ETH-01K), owned by EverEx, Inc., to examine safety and effectiveness in individuals with patellofemoral pain syndrome.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients with peripatellar or posterior patellar pain in one or more knee joints for 3 months or longer Patients with peripatellar or posterior patellar pain provoked by squatting Patients who have pain provoked by 2 or more following activities: prolonged sitting, cycling, running, going up or down stairs, kneeling, compression of the patella, palpation of the patellar facets Patients who signed a written informed consent form  Exclusion Criteria:  Patients with osteoarthritis which scored 3 or higher grade of the Kellgren-Lawrence scale Patients diagnosed with a fracture or dislocation around the knee within the last 3 months Patients who had knee surgery within the last 3 months Patients diagnosed with patellar tendinitis based on imaging within 3 months Patients taking narcotic pain medications for pain control Patients taking or planning to take any medication that is a contraindication within the next 16 weeks at the time of screening Patients who are pregnant Patients currently participating in another clinical trial or have participated in another clinical trial within the past 3 months at the time of screening Patients deemed unsuitable for this study by the investigator - HealthyVolunteers: No - Gender: All - StdAgeList: Child, Adult, Older Adult
Identification of Minimum Focal Points in Vision Curve Formation
Status: Recruiting

The primary objective of this study is to identify how many focal points and at which distances are necessary for reliable visual curve formation and area of the curve (AoC) calculation using mathematical models and comparing the results to measurements acquired from participants that underwent uncomplicated pseudophakic presbyopia surgery.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  age over 40, previous bilateral premium cataract surgery, best corrected visual acuity (BCVA) < 0,2 logMAR  Exclusion Criteria:  taking topical medication to reduce intraocular pressure (IOP), macular diseases, corneal diseases, inability to understand the procedure, postoperative astigmatism >1.50 diopters, postoperative clouding of the posterior capsule - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 40 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult - StudyPopulation: participants that underwent uncomplicated pseudophakic presbyopia correction with bilateral premium intraocular lenses (IOL) implantation - SamplingMethod: Non-Probability Sample
the Effect of Minimally Invasive Technique Assisted by Magnetic Resonance Neurography
Status: Recruiting

The goal of this clinical trial is to to compare the therapeutic effect of minimally invasive surgery guided by magnetic resonance neurography(MRN) compared with non-magnetic resonance assisted minimally invasive surgery in patients with moderate to severe gluteal muscle contracture(GMC). The main question it aims to answer are: magnetic resonance neurography can better help optimize the surgical path of minimally invasive surgery in the treatment of gluteal muscle contracture.

Participants will underwent preoperative magnetic resonance examination according to different groups, and then the experimental group designed individualized surgical approach and MRN-assisted minimally invasive release according to the imaging findings. In the control group, preoperative magnetic resonance examination was only used to assist in the diagnosis and evaluation of gluteal muscle contracture, and the magnetic resonance results were not used to assist in the design of surgical approach. In the control group, non-MRN-assisted minimally invasive release was performed. The researchers will compare the intraoperative surgery-related indicators and postoperative hip function scores and complications of patients in different groups to see if magnetic resonance-assisted surgery has a better postoperative effect.

Eligibility:
- EligibilityCriteria: Inclusion Criteria：  （1). Meet the clinical and imaging diagnostic criteria of GMC ; (2).According to Zhao &#39;s classification system, patients with moderate to severe GMC diagnosed by medical history, symptoms and physical examination ; (3).Conservative treatment is ineffective for at least 6 months, and daily life is significantly affected ; (4).willing to be hospitalized and receive minimally invasive surgery ; (5). Can cooperate to complete the follow-up ; (6).Patients or immediate family members signed informed consent ; (7). Age 18-65 years old  Exclusion Criteria:  . There is clinical or imaging evidence that there is or may be spinal or lower extremity neurological disease ; . There is evidence of hip dysplasia or subluxation ; .after evaluation of intolerance to surgical anesthesia ; .coagulant dysfunction ; . unable to complete the follow-up for various reasons ; . Patients can not complete the scale assessment for other reasons - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult
Biomechanical and Morphological Characterization of PTTD
Status: Recruiting

Posterior tibial tendon dysfunction (PTTD) is a progressive condition of the tendon of the tibialis posterior muscle with symptoms of tendinopathy or even rupture. Functionally, it is associated with the inability to lock the mid foot and thus manifests itself as a main contributor to adult acquired flatfoot deformity.

Concerning treatment, clinical decision making is currently based on a classification integrating various parameters as pain, flexibility of the foot joints, the condition of the posterior tibial tendon assessed through ultrasound imaging and radiographic assessment of arthritic changes. Surprisingly, this classification does not consider any morphologic characteristics (the shape of a bone or joint) or functional, biomechanical characteristics of the foot and ankle, i.e. based on kinematics (e.g. range of motion) and/or kinetics (center of pressure, angular velocity, moment, power absorption and power generation of a joint).

Detailed biomechanical characteristics of the foot and ankle can be reliably collected by instrumented gait analysis wherein a 3D camera system is combined with a force plate and plantar pressure platform. Kinematic studies in the field of PTTD typically considered the foot as a structure consisting of three segments: hind foot, forefoot and hallux. Consequently, the mid foot segment (the Chopart and Lisfranc joints) has been neglected, although it is this segment that is particularly affected in PTTD patients.

The aim of this research is to overcome the limitations of the current classification system and treatment of PTTD patients, by complementing the current standard-of-care clinical assessment with better insight in the pathologic changes that occur in PTTD patients.

Eligibility:
- EligibilityCriteria: Inclusion criteria:  Patient groups:  Posterior tibial tendon dysfunction (all clinical stages) Age 18-675 year ICF obtained  Control group:  No pain complaints No pes plano valgus, PTTD or pes cavo varus or other foot and ankle pathology Age 18-75 year ICF obtained  Exclusion criteria patient and control groups:  Being younger than 18 years Inability to walk without mobility aids Inability to walk < 100 meter Difference in leg length > 3cm Subjects with BMI>30 kg/m², due to less accurate gait analysis by absence of anatomical landmarks Subjects unable to perform a gait analysis Any medical condition possibly affecting normal gait. Pregnancy: at the start or during the study - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult
Spanish Version of Credibility and Expectancy Questionnaire in Patients With Musculoskeletal Injuries
Status: Recruiting

Physiotherapy treatment of musculoskeletal injuries should be performed following the main clinical guidelines of person-centered care. Patients' perception of the abilities and facilities provided by physiotherapists boost a convenient therapeutic relationship. This relation is linked with more satisfaction and adherence during the treatment, as well as credibility and expectancy of the patient related to the treatment. Thus, Credibility and Expectancy questionnaire is normally used to assess that point. CEQ presents good psychometric properties when used in Physisiotherapy interventions, but there is not a spanish version of this questionaire.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Volunteer patients who are going to start physiotherapy treatment due to musculoskeletal injuries. Age above 18 years old. Understanding of the study purpose and signing the informed consent.  Exclusion Criteria:  Patients with cognitive deprivation. Not able to fill in the questionnaires autonomously. Mother tongue different from Spanish. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Patients who are going to start physiotherapy treatment due to musculoskeletal injuries. - SamplingMethod: Probability Sample