The Effects of Bariatric Surgery on Kidney Oxygenation in Obese Adults With Type 2 Diabetes and Hyperfiltration
Status: Recruiting

In this study the investigators will examine the effects of VAT reduction by bariatric surgery on kidney hypoxia and compare kidney oxygenation before- and after surgery in both sexes using BOLD-MRI and measures of kidney hemodynamic function. Furthermore, the investigators will assess whether kidney oxygenation is reduced in obese T2D men and women versus various controls as described below. This will determine whether kidney hypoxia can be appointed as a modifiable pathogenic factor in early DKD and non-surgical interventions targeting kidney hypoxia can be designed to slow DKD progression.

Eligibility:
- EligibilityCriteria: Group 1: T2DM patients with obesity and hyperfiltration  Inclusion criteria:  Caucasian; man or women aged ≥18 years and <55 years. Females must be pre-menopausal Type 2 diabetes mellitus or pre-diabetes with HbA1c ≥45mmol/mol and <10% (<94mmol/mol) BMI ≥35 eGFR>90 ml/min calculated as by CKD-EPI Provision of signed and dated, written informed consent prior to any study specific procedures Hypertension should be controlled, i.e., ≤ 155/95 mmHg. Scheduled for gastric bypass or gastric sleeve  Exclusion criteria:  Diagnosis of type 1 diabetes mellitus Post-menopausal females (defined as no menses >1 year and follicle stimulating hormone (FSH) >31 U/L) Cardiovascular disease event in the last 6 months prior to enrollment as assessed by the investigator, including: myocardial infarction, cardiac surgery or revascularization (CABG/PTCA), unstable angina, heart failure, transient ischemic attack (TIA) or significant cerebrovascular disease, unstable or previously undiagnosed arrhythmia. Chronic use of sodium-glucose transporter-2 inhibitors, oral glucocorticoids, non-steroidal anti-inflammatory drugs (NSAIDs), immune suppressants, chemotherapeutics, antipsychotics, tricyclic antidepressants (TCAs), diuretics, or monoamine oxidase inhibitors. Current urinary tract infection or active nephritis History of allergy/hypersensitivity to any of the test agents Contra-indication for MRI Any other condition that prevents participation as judged by investigator.  Group 2: Non-diabetic lean controls  Inclusion criteria:  Caucasian; male of female aged ≥18 years and <40 years. Females must be pre-menopausal Provision of signed and dated, written informed consent prior to any study specific procedures. Normal glucose tolerance confirmed by HbA1c No hypertension BMI ≥18,5 and <25 kg/m²  Exclusion criteria:  Macro-albuminuria (defined as UACR>30 mg/mmol) Post-menopausal females (defined as no menses >1 year and follicle stimulating hormone (FSH) >31 U/L)*. Cardiovascular disease event in the last 6 months prior to enrollment as assessed by the investigator, including: myocardial infarction, cardiac surgery or revascularization (CABG/PTCA), unstable angina, heart failure, transient ischemic attack (TIA) or significant cerebrovascular disease, unstable or previously undiagnosed arrhythmia. Chronic use of renin-angiotensin-system blockers, sodium-glucose transporter-2 inhibitors, GLP-1 receptor agonists, DPP-4 inhibitors, oral glucocorticoids, non-steroidal anti-inflammatory drugs (NSAIDs), immune suppressants, chemotherapeutics, antipsychotics, tricyclic antidepressants (TCAs), diuretics ormonoamine oxidase inhibitors. Current urinary tract infection or active nephritis History of allergy/hypersensitivity to any of the test agents Contra-indication for MRI - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 55 Years - StdAgeList: Adult - StudyPopulation: Participants in our patient group will be selected from the Bariatric outpatient clinic.  Participants in our control group will be selected from the student campus - SamplingMethod: Non-Probability Sample