rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
Safety and Efficacy Study of Novel Gene Therapy ZM-02 for Retinitis Pigmentosa Patients
Status: Not yet recruiting

This trial is meant to evaluate the safety and efficacy of ZM-02 in Retinitis pigmentosa (RP) patients. Unilateral intravitreal injections (IVT) will be given into the subject's Study Eye.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients who meet all of the following criteria can be selected as subjects:  Clinically diagnosed with retinal pigment degeneration The vision of the eye being tested is no better than the index value, while the vision of the opposite eye is not better than that of the tested eye The subject has had visual experience above the index value In the OCT examination of the tested eye, the disappearance of the ellipsoid zone is observed, but the inner nuclear layer and the nerve fiber layer of the retina are still present The refractive power of the tested eye is between -6.00 D and +6.00 D Not infected with the Human Immunodeficiency Virus (HIV) and other acute and chronic infectious diseases Voluntarily sign an Informed Consent Form (ICF), and the age is not less than 18 years and not more than 65 years Able to fully understand and agree to cooperate with the implementation of the research protocol  Exclusion Criteria:  Subjects who meet any one of the following exclusion criteria will be excluded from the study:  Pregnant women, breastfeeding women, or male and female subjects who do not agree to contraception during the 12 months before and after medication Subjects with narrow anterior chamber angles or any other medical conditions that contraindicate pupil dilation Subjects allergic to corticosteroids, who are unable to tolerate the corticosteroid treatment described in the protocol, or have active 4. concurrent infections that contraindicate treatment Subjects with systemic diseases, or other medical or mental illnesses, or other safety concerns for the study Subjects with other symptoms and/or diseases or conditions that can alter visual function, including but not limited to glaucoma and central nervous system lesions (mild cataracts are not included in this restriction) Eye diseases that may interfere with the assessment of vision during the study and/or interfere with other ocular assessments such as OCT Diseases that may affect the clinical trial, such as tumors, metabolic, immune-related diseases, etc. Subjects who have undergone major eye surgery within the last 3 months before screening Subjects with a history of malignant tumors within the last 5 years Subjects with other retinal diseases not suitable for this study, such as retinal detachment Patients undergoing or potentially undergoing immunosuppressive treatment for other diseases, excluding this study Participation in any clinical trials other than this study within the last 3 months Subjects who have received gene therapy outside of this study Other reasons deemed by the researcher as unsuitable for participation in this study - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult
Cognitive Behavioral and Faith Fellowship to Improve Thy Health
Status: Not yet recruiting

Investigators will examine the efficacy of a faith-based depression intervention, in reducing symptoms of depression among African American adults in Wisconsin. Twelve church groups, each with 10 people (N=120) will be invited to participate. This intervention will be the first evidence-based, faith-based intervention designed for African Americans if validated.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  self-identify as an African American man or woman are ages 18 and older have symptoms of major depressive disorder, as evidenced by score of 10 and higher from the Patient Health Questionnaire-9 (PHQ-9).  Exclusion Criteria:  major psychotic illnesses, such as schizophrenia; current participation in psychotherapy current suicidal ideations (trained staff will conduct a suicide risk assessment and facilitate referral for appropriate care). Medication stabilization. Eligible participants who report recent changes to their psychiatric medications (i.e., initiation of a new medication, change in dose or type of medication) will delay their study enrollment for a stabilization period of 4 weeks. Baseline data collection will be re-administered - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Acute EpiDural Hematoma Treated With Middle Meningeal Artery Embolization: a Randomized Trial (AEDH-MT)
Status: Not yet recruiting

A prospective, multicenter, randomized controlled, open-label, blinded endpoint evaluation study.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age 18 or above； Patients with a clear history of head trauma and confirmed acute epidural hematoma by head CT； An EDH less than 30 cm3 and with less than a 15-mm thickness and with less than a 5-mm midline shift (MLS) in patients with a GCS score greater than 8 without focal deficit； Randomly within 6 hours after injury, and initiate treatment within 8 hours after injury； Epidural hematoma located on the convex surface of the brain (frontal, temporal, parietal, or occipital)； The patient or their representative agrees and signs an informed consent form.  Exclusion Criteria:  Patients who require craniotomy surgery to remove hematoma； Bilateral acute epidural hematoma； Combined acute subdural hematoma； There are obvious brain contusions, lacerations, intracerebral hematomas, etc； Combined intracranial tumors and other intracranial space occupying diseases； Severe damage to combined extracranial organs； mRS score before injury > 2； Coagulation dysfunction (preoperative INR>1.5), abnormal platelet count and function (platelet < 80×109/L)； There are contraindications for cerebral angiography, such as iodine contrast agent allergy, embolization material allergy, renal dysfunction (GFR<30ml/min), etc； There may be anatomical variations that may affect the safety of MMA embolization surgery and are not suitable for endovascular embolization； Severe comorbidities, such as severe heart failure (ejection fraction<50%), lung failure (partial pressure of blood oxygen<60mmHg), and severe liver dysfunction (prothrombin activity<40%), may prevent improvement of the condition or completion of follow-up； Having undergone major surgical procedures within 30 days before surgery, or planning to be hospitalized for surgical treatment within 90 days after surgery； Currently participating in other clinical trials； Pregnant women； Suffering from malignant tumors with an expected lifespan of less than 1 year； Unable to complete follow-up as required by the plan； The physician believes that the patient has other circumstances that are not suitable for participation in this study. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Clinical Characteristics and Surgical Outcomes of the Fellow Eye in Bilateral Retinal Detachments
Status: Not yet recruiting

To assess the clinical features and the surgical outcomes of RD repair surgery of the fellow eye in bilateral retinal detachments

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  All patients that underwent retinal detachment repair surgery for bilateral sequential retinal detachment between January 2016 and December 2023 at the Nancy Regional and University Hospital Center (via pars plana vitrectomy or scleral buckling) and with a minimum of 6 month of post-operative follow-up after the last surgery.  Exclusion Criteria:  Patients that underwent surgery at another facility Patients with a history of previous vitrectomy or Patients with a history of trauma from a penetrating injury or ruptured globe, retinal neovascular condition, hereditary vitreo-retinopathy - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: All patients that underwent retinal detachment repair surgery for bilateral sequentiel retinal detachment between January 2016 and December 2023 at the Nancy Regional and University Hospital Center - SamplingMethod: Non-Probability Sample
A Comparison Between STN-DBS and GPi-DBS in Meige Syndrome Evaluated by Flexible Electrodes
Status: Recruiting

Deep-brain stimulation (DBS) is an effective treatment for patients with Meige syndrome. The globus pallidus interna (GPi) and the subthalamic nucleus (STN) are both accepted targets for this treatment. Researchers designed this study to compare the 12-month outcomes for patients who undergo bilateral stimulation of the GPi or STN.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Primary Meige syndrome was diagnosed by an experienced neurologist. All patients had received systematic and regular treatment for at least 1 year before surgery, including oral drugs and local injection of botulinum toxin A, but the efficacy was not apparent, as the ability to engage with daily life and the quality of life of the patients significantly decreased. Tere were no other serious systemic diseases, such as severe organic heart disease, severe lung, liver and kidney dysfunction, and coagulation dysfunction. Tere was no history of neurological diseases other than Meige syndrome, such as Parkinson's disease or severe cognitive dysfunction. Tere were no serious psychiatric disorders, such as schizophrenia. Preoperative head magnetic resonance imaging (MRI) examinations were normal. Patients of missing follow-up and incomplete clinical data were excluded from the cases.  Exclusion Criteria:  Unilateral facial spas and blepharospasm. Patients with severe disease such as coronary heart disease, stroke. - HealthyVolunteers: No - Gender: All - MinimumAge: 30 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult
Effect of Intestinal Microecology After HDDT Combined With Probiotics for Helicobacter Pylori Eradication
Status: Not yet recruiting

The aim of this study was to evaluate the effect of Intestinal microecology after high dose dual therapy combined with probiotics for Helicobacter pylori eradication

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  age from 18 to 65 years; H.pylori infection diagnosed by 13C-urea breath test; no history of H. pylori eradication.  Exclusion Criteria:  allergy to amoxicillin; Zollinger-Ellison syndrome, GC,upper gastrointestinal bleeding, or active peptic ulcer; coexistence of significant concomitant illnesses, including heart disease, renal failure, hepatic disease, previous abdominal surgery, lactation, or pregnancy; use of PPI and antibiotics within the previous one month; unwillingness to participate in this study. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult
Effectiveness of Ultrapulse for the Treatment of Androgenic Alopecia Among Malaysian: A Quasi-experimental Study
Status: Not yet recruiting

The goal of this study is to to evaluate the effectiveness of Ultrapulse for the treatment of androgenic alopecia among Malaysian. The main questions it aims to answer are:

the efficacy of Ultrapulse in treatment of androgenic alopecia among Malaysian
the safety and adverse effect of Ultrapulse treatment.
the quality of life of androgenic alopecia among Malaysian.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  - Patient with androgenic alopecia with severity of Norwood-Hamilton Scale II to VI for male and Ludwig Scale I to III for female  Exclusion Criteria:  Use of topical or systemic medications affecting hair growth within the 6 months before recruitment Previous hair transplantation, underwent scalp reconstruction procedure, hair braiding or scalp tattoo - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Comparative Effects of Myofascial Stretch and Contract-relax in Children With Spastic cp
Status: Recruiting

Cerebral palsy (CP) is primarily a neuromotor disorder that affects the development of movement, muscle tone and posture.It is one of the three most common lifelong developmental disabilities, the other two being autism and mental retardation causing considerable hardship to affected individuals and their families. CP is a common problem, the worldwide incidence being 2 to 2.5 per 1000 live births. Myofascial therapy is definable by "the facilitation of mechanical, neural and psycho physiological adaptive potential as interfaced by the myofascial system". The PNF contract-relax technique consists of stretching the target muscle, keeping it in position while the patient isometrically contracts it and relaxes in sequence, producing effects such as maintenance and gain in joint mobility, increased muscle strength, and better motor control whereas The modified Ashworth scale is the most universally accepted clinical tool used to measure the increase of muscle tone This study will be randomized clinical trial and will be conducted in Rasool medical centre Gujrat and City hospital Gujrat. This study will be completed within duration of 6 months after the approval of synopsis.Convenience sampling technique will be used to collect the data. A sample size of total 20 patientswill be taken in the study. 20participants will be equally divided into two group's myofascial stretch and contract-relax stretching techniques having 10participants in each group. Informed consent will be sought from them and they will be clearly explained about the purpose of study.Myofascial Stretching will be applied to Group A and Contract-Relax stretching will be applied to Group B.

Results will be analyzed on SPSS.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age between 6 and 12 year(20). Spastic CP child will be including. Communication statusand oriented. Informed written consent of the children's parents was required.  Exclusion Criteria:  Orthopedic surgery on upper limb(1). Received botulinum toxin injection in the upper limb during the last 6 months or who wish to receive it within the period of study(2). Upper Extremities deformities Upper limb Contracture Formation - HealthyVolunteers: No - Gender: All - MinimumAge: 6 Years - MaximumAge: 12 Years - StdAgeList: Child
Effects of Complex Training in Cricket Fast Bowlers
Status: Recruiting

This study will be a randomized controlled trial and the data will be collected from National Cricket Academy and domestic cricket clubs. The sample size will be calculated by conducting a pilot study. There will be three groups. Group-A will be receiving Complex training, Group-B will be receiving Conventional training and Group C as a Control Group. Athletes with same physical fitness level will be recruited. There will be parallel assignment of the participants. Assessor will be kept blinded. All the parameters would be assessed at Baseline, 6 Weeks, 12 Weeks. Physical fitness will be assessed through Field Testing. Bowling performance will be assessed through speed machine and Kinovea Software. Work capacity will be assessed through step testing. Muscle strength will be assessed through Dynamometer. Lastly, BMD will be assessed though Bone Densitometer.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Male bowlers between 18 - 25 years Bowling speed 115-130 km/h Same Run-up speed (20-25 km/h) domestic teams Active in game from last 6 months Athletes with same 1 Repetition Maximum (Bench press and Leg press) Athletes with same BMI category (18.5 - 24.9)  Exclusion Criteria:  Red flags Resistance training from last 6 months Any disabling musculoskeletal injury Glenohumeral Internal Rotation Deficit Scapular Dyskinesia Athletes taking prohibited drugs, Ergogenic aids Any cardiovascular issue . Any systemic disease - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Male - MinimumAge: 18 Years - MaximumAge: 25 Years - StdAgeList: Adult
Mirror Therapy With Sensory Motor Training in Children With CP
Status: Recruiting

The study compares two interventions in CP children: mirror therapy with sensory motor training versus mirror therapy with motor training. Mirror therapy works by manipulating the brain out of pain, ultimately improving movement in patients with one-sided paralysis. It can be used in combination with other therapies to assist patients with cerebral palsy in retraining the brains, restoring function, and enhancing the overall quality of life. The purpose of this study is to use a combination of Mirror therapy with sensory motor training and motor training and observe which one of these combinations has the most desirable effects in improving movement and quality of life in CP Children

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Aged between 6 and 12 years Lack of use of the affected upper limb Level I-III of the Manual Ability Classification System (MACS) Level I-III in the Gross Motor Function Classification System (GMFCS)  Exclusion Criteria:  Disease not associated with congenital hemiplegia Presence of contractures in the affected upper limb affecting the functional movement Surgery in the six months previously to the treatment Botulinum toxin in the two months previously to or during the intervention Pharmacologically uncontrolled epilepsy - HealthyVolunteers: No - Gender: All - MinimumAge: 6 Years - MaximumAge: 12 Years - StdAgeList: Child
Effects of Strength Training of Non-paretic Upper and Lower Limb With or Without Mirror Therapy
Status: Not yet recruiting

The aim of this study is to find the effects of strength training with or without mirror therapy of non-paralytic upper limb for functional activities and in lower limb for gait pattern, balance and stability, and ADLs of paralytic side in patients with acute and sub-acute stroke. A randomized controlled trial that will include total 44 participants .The control group will undergo usual rehabilitation training along with strength training. The trial group will undergo strength training and mirror therapy of NHS on the basis of usual rehabilitation training. For the control group, training time will be 30 minutes, once a day, 3 days a week for 8 weeks. IN trial group, training time will be 30 minutes therapy, once a day, 3 days a week for 8 weeks. were allowed to rest for 3-5 min during each training. Data collected will be analyzed through SPSS 25.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Girls aged 17-24 years with regular --Menstrual cycle Unmarried girls  Exclusion Criteria:  Athletes Married women Girls who were regularly exercising Having any pelvic pathology Abnormal menstrual cycle. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - GenderBased: Yes - MinimumAge: 18 Years - MaximumAge: 24 Years - StdAgeList: Adult
Comparison of Retention Characteristics of Immediate vs Delayed Retainer Delivery Using 3D Digital Model Analysis
Status: Recruiting

Retention has been defined as "the holding of teeth following orthodontic treatment in the treated position for the period of time necessary for the maintenance of the result". Controversies regarding retention regime exist due to lack of high quality evidence regarding duration, type and timing of different type retainer.The present randomised controlled trial will be undertaken to assess the changes and compare if there is any difference in movement of teeth in post orthodontic treatment cases with immediate and delayed (post 7 days) delivery using beggs retainer and change in level of bone biomarker over 6 months period of retention .

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Subjects who required extraction. Optimal functional occlusion at end of treatment (PAR score >70%). Littles irregularity index (Pre-treatment <6mm in both upper and lower arch). Nonsurgical and non-orthopedic patients. Non syndromic patients and no impaction of teeth except third molars. Optimal periodontal condition and Good oral hygiene (probing depth <3mm, gingival index score <1 Good compliance regarding retainer wear.  Exclusion Criteria:  Subjects with incomplete orthodontic treatment. TMJ disorder patients. Any systemic disease affecting bone and general growth. Patients with incomplete records. Patient who fail to follow up or undergo complete treatment. Patient with learning difficulties Patients having antibiotic therapy within previous 3 months and used anti inflammatory drugs in the month before the study - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 45 Years - StdAgeList: Adult
Lung Sonar in Neonatal Respiratory Disorders
Status: Not yet recruiting

This study aimed to determine the value of chest ultrasonography in comparison to other tools as chest x-ray and ABG in diagnosis and follow up of neonates with respiratory disorders.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  neonates with a gestational age ≥28 weeks who are suffering from respiratory disorders.  Exclusion Criteria:  neonates having multiple congenital anomalies, chromosomal aberrations, hydrops fetalis and/or heart failure. - HealthyVolunteers: No - Gender: All - MinimumAge: 1 Day - MaximumAge: 28 Days - StdAgeList: Child - StudyPopulation: All neonates (Term and preterm) presented with respiratory disorders - SamplingMethod: Probability Sample
Investigation of the Effectiveness of Craniosacral Therapy in Patients With Multiple Sclerosis.
Status: Recruiting

Although the cause of Multiple Sclerosis (MS), one of the common demyelinating diseases of the central nervous system, has not yet been fully elucidated, autonomic nervous system dysfunction has been suggested in its etiology. Symptoms such as fatigue, problems with bladder, bowel, cardiovascular, sleep, sexual and sweating functions, abnormal sympathetic skin response or decreased heart rate variation support this hypothesis.

In the treatment of many neurological diseases such as Multiple Sclerosis, complementary medicine practices and non-traditional therapies have recently been shown to be effective in addition to conventional practices. One of these practices, craniosacral therapy (CST), uses manual palpation and manipulation of the craniosacral system to influence sensory, motor, cognitive and emotional processes in the nervous system. In addition, it is thought that applying external force to certain bone elements can have a positive effect on various symptoms in patients with MS, based on the knowledge that it can be transmitted within the system.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  18 to 65 years old Definitive diagnosis of MS by a neurologist EDSS score between 1-5.5 Not receiving active physical therapy services Volunteering.  Exclusion Criteria:  Having a neurological disease other than MS Attacks in the last three months Corticosteraoid use History of surgery on the spine Central and peripheral nervous system disease Pregnancy Oncological diseases Severe comorbid somatic and psychiatric disorders Receiving invasive/manipulative treatment. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult