rjac/clinicaltrials.gov-summary_and_eligibility huggingface dataset:
Beetroot Extract Supplementation Associated With an Exercise Protocol for Chronic Kidney Disease Patients
Status: Not yet recruiting

Chronic kidney disease (CKD) patients often present systemic inflammation and oxidative stress, resulting in metabolic disorders and high rates of disease-associated cardiovascular death. The literature has indicated that dietary control, the use of bioactive compounds, and the practice of regular physical exercise are essential for the prevention and management of CKD and its complications. In this context, beetroot (Beta vulgaris rubra) deserves attention as it is a source of several bioactive compounds, such as nitrate, betaine, and betalain, with beneficial effects for CKD patients, including anti-inflammatory, antioxidant effects, reduction of blood pressure, and vasodilatory action. The antioxidant and anti-inflammatory properties, in addition to their vasodilatory and antihypertensive capacity, can make supplementation of beetroot an excellent nutritional strategy to help in the treatment of CKD patients. So, this research project will bring contributions to the scientific world, providing strategies for application in clinical practice and the care of patients with CKD, on the use of beetroot associated with an exercise protocol as a non-pharmacological strategy in modulating inflammation, oxidative stress, and improved functional capacity. Furthermore, when supplemented hours before physical training, has been identified as an important factor in improving performance in these activities. Therefore, this study aims to evaluate the effects of supplementation (acute and chronic) of beetroot extract associated with an exercise protocol on complications associated with CKD.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients with CKD undergoing conservative treatment (stages G3a-G4); Aged between 18 and 65 years old; Patients undergoing nutritional monitoring for more than 6 months.  Exclusion Criteria:  Patients using catabolic drugs; Smokers Pregnant women; Using antibiotics and of proton pump inhibitors in the last 3 months; Antioxidant supplements and habitual intake of beetroot or nitrate supplement; Those who are clinically unstable (unstable angina, atrial fibrillation, significant cardiac arrhythmia and acute illness in the last month; and glycemic lability); Unable to exercise (amputation without prosthesis); musculoskeletal pain at rest or with minimal physical activity, inability to sit or walk without assistance, use of a walking device, dyspnea at rest or with light exertion; Those with autoimmune diseases and infectious diseases, cancer, liver disease and AIDS. Patients with parathormone (PTH) levels above 500pg/mL; Those who are allergic or intolerant to the components of the juice. Patients with any impediment to completing the proposed exercise protocol, such as due to travel or difficulty accessing the location where the research will be carried out. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult
Effects of Cinnamomum Supplementation in Chronic Kidney Disease Patients
Status: Not yet recruiting

Patients with chronic kidney disease (CKD) experience many complications related to inflammation and oxidative stress that are closely related to the progression of kidney failure and increased mortality. Furthermore, these patients may have intestinal dysbiosis associated with persistent uremia, generating greater production of uremic toxins arising from the metabolism of intestinal bacteria and also helping to maintain the inflammatory process and oxidative stress. In this context, some nutritional strategies have been proposed as an adjuvant therapeutic alternative to modulate inflammation and improve the antioxidant response of patients with CKD, and even more so to modulate the intestinal microbiota. Based on the consolidated knowledge of the role of nutrients and bioactive compounds on the expression of genes related to inflammation, oxidative stress, and also the modulation of the intestinal microbiota, cinnamon, a member of the Lauraceae family, has been widely used as a spice and traditional herbal medicine for centuries and has indicated beneficial benefits in cardiovascular diseases, obesity, diabetes. The bioactive compounds in cinnamomum, such as cinnamaldehyde, cinnamic acid, and cinnamate, can attenuate oxidative stress, inflammation, hyperglycemia, intestinal dysbiosis, and dyslipidemia, which are common complications in CKD patients. Therefore, the present project proposes a longitudinal clinical trial study that aims to evaluate the effects of cinnamomum on transcription factors and inflammatory markers, oxidative stress and modulation of intestinal health in patients with CKD on hemodialysis.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  patients with CKD undergoing conservative treatment stages G3a-G4 patient in stage 5 (GFR < 15 mL/min), undergoing hemodialysis for more than 6 months and having an arteriovenous fistula (AVF) as vascular access.  Exclusion Criteria:  pregnant, lactating, smoker patients patients using antibiotics in the last 3 months, antioxidant supplements and habitual cinnamon intake patients with autoimmune and infectious diseases, cancer, liver disease and AIDS, illiterate people and people with disabilities (visual, hearing) patients who are allergic or intolerant to the components of the capsules. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult
Optimized Rehabilitation of Older Adults With Hip Fracture and Signs of Cognitive Impairment - Feasibility Study
Status: Recruiting

Older adults suffering from a hip fracture are a significant concern, with higher incidence rates among women. Mortality rates post-hip fracture are alarming, with up to 8-fold increased risk within 3 months and significant percentages within 30 days and 12 months. Older adults with hip fracture face challenges in regaining pre-fracture level of function, especially those with cognitive impairment, which affects 25% to 40% of cases and increases mortality risk. While interventions exist, such as progressive strength training and structured exercise programs, patients with hip fracture don't consistently restore pre-fracture function, particularly in cognitively impaired patients, who are often excluded from studies. Limited evidence exists on effective management for this subgroup, with a lack of clarity on community-based rehabilitation. Although guidelines suggest exercise interventions for patients with mild to moderate cognitive impairment, the specifics remain uncertain due to insufficient research focused solely on this population.

This feasibility study aims to assess the practicality and safety of implementing a 12-week individualized, progressive exercise program for older adults with hip fracture and cognitive impairment in an outpatient setting. Additionally, the investigators seek to gather qualitative insights through observations and interviews regarding participants' experiences and the perceived value of rehabilitation post-hip fracture, particularly focusing on the exercise intervention provided.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Recently (within 3 weeks) underwent surgical repair of a hip fracture (femoral neck or trochanteric fracture) Independent pre-fracture ambulatory function (≥2 on the New Mobility Score on indoor walking) Having signs of cognitive impairment measured with the Mini-Mental Score Examination of <24 points, or a verified dementia diagnosis, or on information from the patient record Living in their own home, nursing home, or assisted living facilities Informed consent by patient  Exclusion Criteria:  Pathological hip fracture Having signs of severe dementia measured with the Mini-Mental State Examination (<10 points) Non-Danish speaking Patients with an unstable health condition (e.g. not treated high blood pressure (>180 mm HG)) evaluated by medical consultant "Safety concerns" (e.g. underlying comorbidities that might be associated with serious adverse events) - not safe to participate in the opinion of the investigator Having behavioral or psychotic disorders Alcohol or drug abuse Unable to participate in the intervention (e.g. due to blindness, no language) Patients with any weight-bearing restrictions after surgery - HealthyVolunteers: No - Gender: All - MinimumAge: 65 Years - StdAgeList: Older Adult
Optic Nerve Sheath Diameter in Hypertensive Emergency
Status: Not yet recruiting

This prospective observational study investigates the potential of point-of-care ultrasonography of the optic nerve sheath diameter (ONSD) to rule out papilledema in patients with suspected hypertensive emergency. The primary focus is on assessing ONSD sensitivity in identifying papilledema (hypertensive retinopathy grade 4), while secondary endpoints include hypertensive retinopathy grade 3, hypertensive encephalopathy, and the need for intravenous rapid-acting medications to lower elevated blood pressure. This study aims to determine the diagnostic characteristics of this procedure for the diagnosis of hypertensive retinopathy, thus assessing its potential as a screening tool to rule out hypertensive retinopathy by the acute internal medicine doctor.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  ≥ 18 years old Any patient presenting to the emergency department (ED) with suspected hypertensive emergency i.e.: blood pressure of > 200 millimetres of mercury (mmHg) systolic and/or > 120 mmHg diastolic  Exclusion Criteria:  Patients with preexisting optic nerve head changes such as glaucoma, pre-existing retinal artery/vein occlusions or any other condition that makes assessment of the fundi impossible. Primary neurological cause of hypertension: ischemic cerebrovascular incident - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Patients presenting to the emergency department with suspected hypertensive emergency. - SamplingMethod: Non-Probability Sample
Impact of Early Mobilization on SAH Patients Physiological Parameters
Status: Not yet recruiting

The aim of the study is to evaluate the physiological response to out-of-bed mobilization in patients admitted to the intensive care unit for subarachnoid hemorrhage. More specifically, the aim is to measure the impact on cerebral perfusion, lung aeration, cardiovascular and respiratory parameters.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age ≥ 18 years  Aneurysmal SAH Severity score World Federation Neurological Surgeons I to IV Secured aneurysm Eligible for their first early mobilization  Exclusion Criteria:  Sedated patient Disturbed alertness, coma Unsecured aneurysm Patients under legal protection (guardianship, curatorship, safeguard of justice) - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Patients admitted to intensive care for aneurysmal subarachnoid hemorrhage (SAH) and eligible for their first outof-bed mobilization - SamplingMethod: Non-Probability Sample
Single Versus Dual Implant Fixation of Distal Femur Fractures
Status: Not yet recruiting

The goal of this clinical trial is to compare two types of surgical fixation in patients with specific kinds of distal femur fractures. The main questions it aims to answer is which operation for distal femur fractures is better for efficient return to work and everyday activities.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Age greater than or equal to 18 years Surgically treated displaced distal femur extra articular or complete articular fractures  Exclusion Criteria:  Patients with injury features that preclude treatment with 2 implants Patients unlikely to follow-up due to homelessness, or planning follow up at another institution Body Mass Index (BMI) > 40 Injury due to ground level fall Patient that speaks neither English or Spanish Patients with multisystem injuries that could preclude return to work < 18 years of age Prisoner - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
Xanthohumol and Viral Infections (XL)
Status: Recruiting

The aim of the present study is to determine if a regular oral supplementation of xanthohumol attenuate the severity of symptoms and duration of´viral infections.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  healthy BMI >18 kg/m² or < 28kg/m²  Exclusion Criteria:  food intolerances, food allergies, chronic inflammatory diseases, metabolic diseases, viral or bacterial infections within the last 3 weeks of inclusion, intake of immunosuppressive medication, severe acute respiratory syndrome coronavirus type 2-infection in the last 4 months, influenza infection in the "current" flu season - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 70 Years - StdAgeList: Adult, Older Adult
Hop Compounds on the Immune System (VH)
Status: Recruiting

The aim of the present study is to determine the effect of Iso-alpha-Acids and Xanthohumol from hops on the immune response of healthy participants over a timeframe of 6 hours.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  healthy BMI: >18,5 kg/m² or <30 kg/m²  Exclusion Criteria:  food intolerances, food allergies, chronic inflammatory diseases, metabolic diseases, viral or bacterial infections within the last 3 weeks of inclusion, intake of immunosuppressive medication - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 70 Years - StdAgeList: Adult, Older Adult
Prediction of Lymph Node Metastasis in Patients With Thyroid Malignancy by a New Scale
Status: Recruiting

The incidence of papillary thyroid cancer (PTC) has been on the rise in recent years, and 20%-50% of PTC patients will have lymph node metastasis. Lymph node involvement in PTC patients is usually related to the recurrence of PTC after surgery, and 30% of patients recur without lymph node dissection, with the risk of central cervical lymph node metastasis being the greatest, so it seems to be a good choice to perform lymph node dissection on patients after thyroidectomy, but in fact, there are controversies at home and abroad as to whether to perform lymph node dissection or not. The 2021 Chinese Society of Clinical Oncology (CSCO) guidelines for the diagnosis and treatment of differentiated thyroid cancer state that prophylactic central lymph node dissection (PCND) may increase the incidence of postoperative complications, but due to the high metastatic rate of PTC and the ability of PCND to effectively prevent recurrence and reoperation, countries in the East Asian region perform prophylactic lymph node dissection on almost all patients with PTC. However, for more countries in Europe and the United States, performing PCND has become a non-essential, individualized option. The aim of this study is to collect multifactorial data from more than 1,000 patients who have undergone previous thyroidectomy from 2021 to 2023, and to develop a novel scoring scale that can be used to individualize patients' scores based on a variety of factors prior to surgery, so that patients can be more accurately predicted to have lymph node metastasis and need prophylactic lymph node dissection prior to surgery, and patients who do not need dissection can avoid surgery. For patients who do not need lymph node dissection, complications caused by surgery can be avoided, while for patients who do have lymph node metastasis, recurrence of their cancer can be prevented. This will change the status quo of not being able to accurately determine the actual situation through simple preoperative examination or performing prophylactic lymph node dissection for all PTC patients.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Papillary thyroid cancer Conscious and able to communicate normally Age 16-80 years  Exclusion Criteria:  Preoperative or postoperative pathology suggests other types of tumors, such as medullary carcinoma or undifferentiated carcinoma. Less than 16 years of age - HealthyVolunteers: No - Gender: All - MinimumAge: 16 Years - MaximumAge: 80 Years - StdAgeList: Child, Adult, Older Adult - StudyPopulation: From 2021 to 2023, 500 patients with previous papillary thyroid cancer surgery were selected at the Second Affiliated Hospital of Xi'an Jiaotong University for the quantitative rating scale, as well as 300 newly admitted papillary thyroid cancer patients for subsequent validation. - SamplingMethod: Probability Sample
RCT GBR One Stages Comparing A-Oss and Autogenous Bone Versus A-Oss and LCR-A
Status: Not yet recruiting

The aim of this randomized controlled trial is to evaluate the tridimensional bone stability after horizontal one-stage GBR using collagene membrane (OssMem) with a mix of Bovine Bone Substitute (A-Oss) and autogenous bone (test group) versus A-Oss and LCR-A, a synthetic bone (control group).

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Patients that required an implant supported restoration and staged horizontal guided bone regeneration (defect of class IV according to Cawed and Howell) in both mandible or maxilla. Patents able to understand and sign an informed consent. Patients were to be 18 years or older with a residual horizontal ridge thickness of 4 mm or less (Cawood-Howell Class III- IV) in the intended implant site. Smokers will be categorized into: 1) non smokers; 2) moderate smokers (smoking up to 10 cigarettes/day); 3) heavy smokers (smoking more than 11 cigarettes/day). Only categories 1 and 2 will be included.  Exclusion Criteria:  General contraindications to implant surgery. Patients irradiated in the head and neck area. Immunosuppressed or immunocompromised patients. Patients treated or under treatment with intravenous amino-bisphosphonates. Patients with untreated periodontitis. Patients with poor oral hygiene and motivation. Uncontrolled diabetes. Pregnancy or nursing. Substance abuser. Heavy smokers (smoking more than 11 cigarettes/day). Psychiatric problems or unrealistic expectations. Lack of opposite occluding dentition in the area intended for implant placement. Immediate implants (extractive sites will have to be healed from 6-8 weeks). Patients participating in other studies, if the present protocol cannot be properly adhered to. Patients referred only for implant placement and cannot be followed ant the treating centre. Patients unable to be followed for 5 years - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
LUNGevity: Lung Cancer Stigma Community Based Participatory Research
Status: Not yet recruiting

Lung cancer survival rates are low for intersectional underserved groups. Lung cancer stigma and intersectional stigma related to minoritized group status leads to increased morbidity and mortality and health disparities. Mindfulness interventions have been shown to decrease stigma and the negative impacts of stigma, however, these interventions have never been tested to decrease lung cancer stigma specifically. In this study, the investigators will use Community Based Participatory Research framework and MOST methodology to build and optimize a brief virtual mindfulness intervention to decrease lung cancer stigma, through first building a diverse coalition of lung cancer patients on a participatory action council.

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Participants must be patients 18 years of age or older with a history of tobacco use to qualify for study inclusion. At least a portion of the participants will also need to be current lung cancer patients. Participants must be able to read and understand English and have normal to corrected vision and hearing. For the Community Advisory Board (CAB), participants must have been diagnosed with lung cancer, be at least 18 years of age or older, and self-identify as being part of an underrepresented group identity.  Exclusion Criteria:  Any potential participants who do not meet the above inclusion criteria will be excluded from the study. Patients who are under the age of 18 and who do not have a history of tobacco use will be excluded from participating in the study. Individuals who cannot read or understand English or who do not have normal to corrected vision and hearing will be excluded from the study. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult
SOI Immediately vs Delayed
Status: Not yet recruiting

The aim of this randomized controlled trial is to compare the clinical and radiographic of immediately loaded, immediate (post-extractive, test group) versus delayed (control group) implants with new SOI surface

Eligibility:
- EligibilityCriteria: Inclusion Criteria:  Any patient with at least one hopeless tooth in the mandible or maxilla, located between premolars, with intact post extractive alveolus. The implants must to engage at least 3 (mandible) to 5 (maxilla) mm of residual native bone over the socket. Patients with 18 years or older, and able to sign an informed consent. Smokers will be included and categorized into: 1) non smokers; 2) moderate smokers (smoking up to 10 cigarettes/day); 3) heavy smokers (smoking more than 11 cigarettes/day). Heavy smokers will be excluded. Biotype will be categorized in thin (≤1 mm), medium (>1 - <2 mm) or thick (≥2 mm).  Exclusion Criteria:  General contraindications to implant surgery. Patients irradiated in the head and neck area. Immunosuppressed or immunocompromised patients. Patients treated or under treatment with intravenous amino-bisphosphonates. Patients with untreated periodontitis. Patients with poor oral hygiene and motivation. Uncontrolled diabetes. Heavy smokers. Pregnancy or nursing. Substance abuser. Psychiatric problems or unrealistic expectations. Lack of opposite occluding dentition in the area intended for implant placement. Patients with infection and or inflammation in the area intended for implant placement. Patients participating in other studies, if the present protocol cannot be properly adhered to. Patients referred only for implant placement and cannot be followed ant the treating centre. Patients unable to be followed for 5 years - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult