Mississippi Administrative Code › Title 15 - Mississippi Department of Health › Part 22 - Medical Cannabis Program › Subpart 11 - Enforcement and Penalties › Appendix 15-22-11.A

Current through June 25, 2024
Key to Table 1:
*
CAS Number = Chemical Abstract Services Registry
				  number
*
CFU = Colony-forming unit, a method to estimate the
				  number of viable bacteria or fungal cells in a sample.
A. Microbial
								Contaminants
Analyte
Maximum Allowable
								Contaminants
Required Action
Total coliform
100 CFU/g
Use to make a concentrate or extract if the
								processing method effectively sterilizes the batch and retested or
								destroy
Shiga toxin- producing Escherichia
								coli
Detectable in 1 gram
Destroy
Salmonella
spp.
Detectable in 1 gram
Destroy
Aspergillus flavus, Aspergillus fumigatus,
								Aspergillus niger,
and
Aspergillus terreus
Inhalable: Detectable in 1 gram
Use to make a concentrate or extract if the
								processing method effectively sterilizes the batch and retest or destroy
Mycotoxins: Aflatoxin B1, B2, G1, and G2 Ochratoxin
								A
Cannabis product, except a cannabis product
								intended for topical application, prepared from an extract or concentrate of
								medical cannabis
Destroy
Total Mold and Yeast
10,000 CFU/g
Use to make a concentrate or extract if the
								processing method effectively sterilizes the batch and retest or destroy
B. Heavy Metals
Analyte
Maximum Allowable
								Concentration (ppm)
Required Action
Inhaled Flower
Inhaled
								Concentrates
Other
Arsenic
0.4
0.2
1.5
Remediate and retest, or Destroy
*Copper is required for vaping products only
Cadmium
0.4
0.2
0.5
Lead
1.0
0.5
0.5
Mercury
0.2
0.1
3.0
Total Chromium
1.2
0.6
2.0
Nickel
1.0
0.5
N/A
Copper
N/A
3.0*
N/A
C. Residual
								Solvents
Analyte
CAS Number
Maximum Allowable
								Concentration
Required Action
Acetone
67-64-1
1,000 ppm
Remediate and retest, or Destroy
Acetonitrile
75-05-8
410 ppm
Benzene
71-43-2
2 ppm
Butanes (measured as the cumulative residue of
								n-butane and isobutane) respectively
106-97-8 and 75-28-5,
5,000 ppm
Chloroform
67-66-3
60 ppm
Dichloromethane
75-09-2
600 ppm
Ethanol
64-17-5
5,000 ppm
Ethyl Acetate
141-78-6
5,000 ppm
Ethyl Ether
60-29-7
5,000 ppm
Heptane
142-82-5
5,000 ppm
Hexanes (measured as the cumulative residue of
								n-hexane, 2-methylpentane, 3-methylpentane, 2,2-dimethylbutane, and
								2,3-dimethylbutane)
110-54-3, 107-83-5, and 79-29-8
290 ppm
Isopropyl Acetate
108-21-4
5,000 ppm
Methanol
67-56-1
3,000 ppm
Pentanes (measured as the cumulative residue of
								n-pentane, iso- pentane, and neo- pentane)
109-66-0, 78-78-4, and 463-82-1
5,000 ppm
2-Propanol (IPA)
67-63-0
5,000 ppm
Propane
74-98-6
5,000 ppm
Toluene
108-88-3
890 ppm
Xylenes (measured as the cumulative residue of
								1,2-dimethylbenzene, 1,3-dimethylbenzene, and 1,4-dimethylbenzene, And the
								non-xylene, ethyl benzene)
1330-20-7 (95-47-6,108-38-3, and 106-42-3, and
								100-41-4)
2,170 ppm
Dimethylbenzene, and 1,4-dimethylbenzene, and the
								non-xylene, ethyl benzene)
D. Pesticides, Fungicides,
								Growth Regulators
Analyte
CAS Number
Maximum Allowable
								Concentration
Required Action
Abamectin
71751-41-2
0.5 ppm
Destroy
Acephate
30560-19-1
0.4 ppm
Acequinocyl
57960-19-7
2.0 ppm
Acetamiprid
135410-20-7
0.2 ppm
Aldicarb
116-06-3
0.4 ppm
Azoxystrobin
131860-33-8
0.2 ppm
Bifenazate
149877-41-8
0.2 ppm
Bifenthrin
82657-04-3
0.2 ppm
Boscalid
188425-85-6
0.4 ppm
Carbaryl
63-25-2
0.2 ppm
Carbofuran
1563-66-2
0.2 ppm
Chlorantraniliprole
500008-45-7
0.2 ppm
Chlorfenapyr
122453-73-0
1.0 ppm
Chlormequat chloride
7003-89-6
0.2 ppm
Chlorpyrifos
2921-88-2
0.2 ppm
Clofentezine
74115-24-5
0.2 ppm
Cyfluthrin
68359-37-5
1.0 ppm
Cypermethrin
52315-07-8
1.0 ppm
Daminozide
1596-84-5
1.0 ppm
DDVP (Dichlorvos)
62-73-7
0.1 ppm
Diazinon
333-41-5
0.2 ppm
Destroy
Dimethoate
60-51-5
0.2 ppm
Ethoprophos
13194-48-4
0.2 ppm
Etofenprox
80844-07-1
0.4 ppm
Etoxazole
153233-91-1
0.2 ppm
Fenoxycarb
72490-01-8
0.2 ppm
Fenpyroximate
134098-61-6
0.4 ppm
Fipronil
120068-37-3
0.4 ppm
Flonicamid
158062-67-0
1.0 ppm
Fludioxonil
131341-86-1
0.4 ppm
Hexythiazox
78587-05-0
1.0 ppm
Imazalil
35554-44-0
0.2 ppm
Imidacloprid
138261-41-3
0.4 ppm
Kresoxim-methyl
143390-89-0
0.4 ppm
Malathion
121-75-5
0.2 ppm
Metalaxyl
57837-19-1
0.2 ppm
Methiocarb
2032-65-7
0.2 ppm
Methomyl
16752-77-5
0.4 ppm
Methyl parathion
298-00-0
0.2 ppm
Myclobutanil
88671-89-0
0.2 ppm
Naled
300-76-5
0.5 ppm
Oxamyl
23135-22-0
1.0 ppm
Paclobutrazol
76738-62-0
0.4 ppm
Permethrins (measured as the cumulative residue of
								cis- and trans-isomers)
52645-53-1(54774-45-7 and 51877-74-8)
0.2 ppm
Phosmet
732-11-6
0.2 ppm
Piperonylbutoxide
51-03-6
2.0 ppm
Prallethrin
23031-36-9
0.2 ppm
Propiconazole
60207-90-1
0.4 ppm
Propoxur
114-26-1
0.2 ppm
Pyrethrins (measured as the cumulative residue of
								pyrethrin 1, cinerin 1 and jasmolin 1)
8003-34-7(121-21-1, 25402-06-6, and
								4466-14-2)
1.0 ppm
Pyridaben
96489-71-3
0.2 ppm
Spinosad
168316-95-8
0.2 ppm
Spiromesifen
283594-90-1
0.2 ppm
Spirotetramat
203313-25-1
0.2 ppm
Spiroxamine
118134-30-8
0.4 ppm
Tebuconazole
107534-96-3
0.4 ppm
Thiacloprid
111988-49-9
0.2 ppm
Thiamethoxam
153719-23-4
0.2 ppm
Trifloxystrobin
141517-21-7
0.2 ppm
E. Potency
Analyte
Labeling
Required Action
Tetrahydro-cannabinolic acid (THC-A)
Label claim is not within ±10 % of tested
								value
Revise label as necessary
Delta-9- tetrahydrocannabinol ([DELTA9-THC)
Cannabidiolic acid (CBD-A)
Cannabidiol (CBD)
Terpenoids (primary and secondary)
Label claim is not within ±10 % of tested
								value
Revise label as necessary
F. Moisture Content and Water
								Activity Testing
Measurement
Allowable
								Measurement
Required Action
Water activity
> 0.65 Aw
Destroy
Moisture content
> than 15%
Remediate and retest
Table 2
Quality Control
								Sample
Acceptance
								Criteria
Frequency
Positive control
Produces expected result, positive result
Per Batch
Negative control
Produces expected result, negative result
Per Batch
Duplicate sample
Results shall concur
Per Run
Analyst or technician Quantitative Performance
								Plate count comparisons monthly
Within 10% for all analysts
Monthly
Table 3
Quality Control
								Sample
Acceptance
								Criteria
Corrective
								Action
Positive control
Produces expected result, positive result
Re-prep and reanalyze the entire analytical batch,
								once. If problem persists, locate and remedy the source of unexpected result,
								then re-prep samples and reanalyze with a new set of controls.
Negative control
Produces expected result, negative result
Re-prep and reanalyze the entire analytical batch,
								once. If problem persists, locate and remedy the source of unexpected result,
								then re-prep samples and reanalyze with a new set of controls.
Laboratory replicate sample
Sample results shall concur
Reanalyze sample and associated replicate sample
								once. If problem persists, re-prep samples and reanalyze.
Table 4
Quality Control
								Sample
Acceptance
								Criteria
Corrective
								Action
Method Blank Sample
Not to exceed LOQ
Reanalyze entire analytical batch once. If method
								blank is still greater than the LOQ for any analyte, locate the source of
								contamination then re-prep samples and reanalyze.
Laboratory Control Sample
RPD <=20%
Reanalyze the entire analytical batch, once. If
								problem persists, re-prep samples and reanalyze or re-run the initial
								calibration curve.
Duplicate Sample
RPD <=20%
Reanalyze sample and associated replicate sample
								once. If problem persists, re-prep samples and reanalyze.
Matrix Spike Sample/Matrix Spike Duplicate
RPD <=20%
Reanalyze sample and associated matrix spike sample
								once. If problem persists, re-prep samples and reanalyze.
CCV
RPD <=20% except for lowest point, which can be
								±30%
Reanalyze all samples that followed the last CCV
								that met the acceptance criteria. If CCV still fails, re-run the initial
								calibration curve and all samples in the analytical sequence.