Michigan Administrative Code › Department - Labor and Economic Opportunity › MIOSHA › General Industry and Construction Safety and Occupational Health Standards › Occupational Health Standards › Part 554 - BLOODBORNE INFECTIOUS DISEASES › Section R. 325.70012 - HIV and HBV research laboratories and production facilities

Current through Vol. 24-12, July 15, 2024
Rule 12.
(1)
					 This rule applies to research laboratories and production facilities that are
					 engaged in the culture, production, concentration, experimentation, and
					 manipulation of HIV and HBV. This rule applies to such laboratories and
					 facilities in addition to the other requirements of these rules. This rule does
					 not apply to clinical or diagnostic laboratories that are engaged solely in the
					 analysis of blood, tissues, or organs.
(2) Research laboratories and production
					 facilities shall be in compliance with all of the following requirements:
(a) All infectious liquid or solid waste
					 shall be incinerated or decontaminated by a method known to effectively destroy
					 bloodborne pathogens before being disposed of.
(b) Laboratory doors shall be kept closed
					 when work involving HIV or HBV is in progress.
(c) Contaminated materials that are to be
					 decontaminated at a site away from the work area shall be placed in a durable,
					 leakproof, labeled or color-coded container that is closed before being removed
					 from the work area.
(d) Access to
					 the work area shall be limited to authorized persons only.Written policies and
					 procedures shall be established whereby only persons who have been advised of
					 the biohazard, who meet any specific entry requirements, and who comply with
					 all entry and exit procedures shall be allowed to enter the work areas and
					 animal rooms.
(e) When other
					 potentially infectious material or infected animals are present in the work
					 area or containment module, a hazard warning sign that incorporates the
					 universal biohazard symbol shall be posted on all access doors. The hazard
					 warning sign shall be in compliance with the provisions of
					 R
					 325.70014(1).
(f) All activities that involve other
					 potentially infectious material shall be conducted in biological safety
					 cabinets or other physical containment devices within the containment module.
					 Work with such material shall not be conducted on the open bench.
(g) Laboratory coats, gowns, smocks,
					 uniforms, or other appropriate protective clothing shall be used in the work
					 area and animal rooms.Protective clothing shall not be worn outside of the work
					 area and shall be decontaminated before being laundered.
(h) Special care shall be taken to avoid skin
					 contamination with other potentially infectious materials. Gloves shall be worn
					 when handling infected animals and when making contact with other potentially
					 infectious materials is unavoidable.
(i) All waste from work areas, including
					 animal rooms, shall be incinerated or decontaminated by a method known to
					 effectively destroy bloodborne pathogens before disposal.
(j) Vacuum lines shall be protected with
					 high-efficiency particulate air (HEPA) filters, or equivalent filters, and
					 liquid disinfectant traps.Filters and traps shall be checked routinely and
					 maintained or replaced as necessary.
(k) Hypodermic needles, syringes, and other
					 sharp instruments shall be used only when a safer alternate technique is not
					 feasible. Only needle-locking syringes or disposable syringe with needle units
					 that have a needle as an integral part of the syringe shall be used for the
					 injection or aspiration of other potentially infectious material. Extreme
					 caution shall be used when handling needles and syringes to avoid
					 autoinoculation and the generation of aerosols during use and disposal. A
					 needle shall not be bent, sheared, replaced in the sheath or guard, or removed
					 from the syringe after being used. The needle and syringe shall be promptly
					 placed in a puncture-resistant container and decontaminated, preferably by
					 autoclaving, before being discarded or reused.
(l) A spill or accident that results in an
					 exposure incident shall be immediately reported to the laboratory director or
					 another responsible person. Spills shall immediately be contained and cleaned
					 up by appropriate professional staff who are trained and equipped to work with
					 potentially concentrated infectious material.
(m) A biosafety manual shall be prepared or
					 adopted and reviewed and updated at least annually. Personnel shall be advised
					 of potential hazards and shall be required to read and follow instructions on
					 practices and procedures.
(n) Both
					 of the following containment equipment requirements shall be complied with:
(i) Class I, II, or III certified biological
					 safety cabinets or other appropriate combinations of personal protection or
					 physical containment devices, such as any of the following, shall be used for
					 all activities with other potentially infectious material that poses a threat
					 of exposure to droplets, splashes, spills, or aerosols:
(A) Special protective clothing.
(B) Respirators.
(C) Centrifuge safety cups.
(D) Sealed centrifuge rotors.
(E) Containment caging for animals.
(ii) Biological safety cabinets
					 shall be certified when installed, at least annually, and when they are
					 relocated.