reglab/statecodes huggingface dataset:
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 52 - Voluntary Registration of Environmental Assessors [Repealed] › Section 69203 - REA II Criteria for Registration. [Repealed]

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
1. Change
				  without regulatory effect renumbering title 14, section
				  19033 to title 22, section
				  69203, including amendment of
				  section and NOTE, filed 7-27-2006 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2006, No. 30).
2. Change without regulatory
				  effect repealing section filed 1-7-2013 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2013, No. 2).
Note: Authority cited: Sections
					 25570.3
					 and
					 58004.5,
					 Health and Safety Code. Reference: Sections
					 25570-
					 25570.4,
					 Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 52 - Voluntary Registration of Environmental Assessors [Repealed] › Section 69204 - REA II Application for Registration. [Repealed]

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
1. Change
				  without regulatory effect renumbering title 14, section
				  19034 to title 22, section
				  69204, including amendment of
				  section and NOTE, filed 7-27-2006 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2006, No. 30).
2. Change without regulatory
				  effect repealing section filed 1-7-2013 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2013, No. 2).
Note: Authority cited: Sections
					 25570.3
					 and
					 58004.5,
					 Health and Safety Code. Reference: Sections
					 25570-
					 25570.4,
					 Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 52 - Voluntary Registration of Environmental Assessors [Repealed] › Section 69205 - DTSC's Review of Application. [Repealed]

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
1. Change
				  without regulatory effect renumbering title 14, section
				  19035 to title 22, section
				  69205, including amendment of
				  section heading, section and NOTE, filed 7-27-2006 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2006, No. 30).
2. Change without regulatory
				  effect repealing section filed 1-7-2013 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2013, No. 2).
Note: Authority cited: Sections
					 25570.3
					 and
					 58004.5,
					 Health and Safety Code. Reference: Sections
					 25570-
					 25570.4,
					 Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 52 - Voluntary Registration of Environmental Assessors [Repealed] › Section 69206 - REA II Denial of Registration. [Repealed]

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
1. Change
				  without regulatory effect renumbering title 14, section
				  19036 to title 22, section
				  69206, including amendment of
				  section and NOTE, filed 7-27-2006 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2006, No. 30).
2. Change without regulatory
				  effect repealing section filed 1-7-2013 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2013, No. 2).
Note: Authority cited: Sections
					 25570.3
					 and
					 58004.5,
					 Health and Safety Code. Reference: Sections
					 25570-
					 25570.4,
					 Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 52 - Voluntary Registration of Environmental Assessors [Repealed] › Section 69207 - REA II Renewal of Registration. [Repealed]

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
1. Change
				  without regulatory effect renumbering title 14, section
				  19037 to title 22, section
				  69207, including amendment of
				  section and NOTE, filed 7-27-2006 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2006, No. 30).
2. Change without regulatory
				  effect repealing section filed 1-7-2013 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2013, No. 2).
Note: Authority cited: Sections
					 25570.3
					 and
					 58004.5,
					 Health and Safety Code. Reference: Sections
					 25570-
					 25570.4,
					 Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 52 - Voluntary Registration of Environmental Assessors [Repealed] › Section 69208 - REA II Rescission of Registration. [Repealed]

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
1. Change
				  without regulatory effect renumbering title 14, section
				  19038 to title 22, section
				  69208, including amendment of
				  section and NOTE, filed 7-27-2006 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2006, No. 30).
2. Change without regulatory
				  effect repealing section filed 1-7-2013 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2013, No. 2).
Note: Authority cited: Sections
					 25570.3
					 and
					 58004.5,
					 Health and Safety Code. Reference: Sections
					 25570-
					 25570.4,
					 Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 52 - Voluntary Registration of Environmental Assessors [Repealed] › Section 69209 - REA II Appeal Procedures. [Repealed]

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
1. Change
				  without regulatory effect renumbering title 14, section
				  19039 to title 22, section
				  69209, including amendment of
				  section and NOTE, filed 7-27-2006 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2006, No. 30).
2. Change without regulatory
				  effect repealing section filed 1-7-2013 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2013, No. 2).
Note: Authority cited: Sections
					 25570.3
					 and
					 58004.5,
					 Health and Safety Code. Reference: Sections
					 25570-
					 25570.4,
					 Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 52 - Voluntary Registration of Environmental Assessors [Repealed] › Section 69210 - REA II Audits. [Repealed]

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
1. Change
				  without regulatory effect renumbering title 14, section
				  19040 to title 22, section
				  69210, including amendment of
				  section and NOTE, filed 7-27-2006 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2006, No. 30).
2. Change without regulatory
				  effect repealing section filed 1-7-2013 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2013, No. 2).
Note: Authority cited: Sections
					 25570.3
					 and
					 58004.5,
					 Health and Safety Code. Reference: Sections
					 25570-
					 25570.4,
					 Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 52 - Voluntary Registration of Environmental Assessors [Repealed] › Section 69211 - Performance Standards. [Repealed]

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
1. Change
				  without regulatory effect renumbering title 14, section
				  19041 to title 22, section
				  69211, including amendment of
				  section and NOTE, filed 7-27-2006 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2006, No. 30).
2. Change without regulatory
				  effect repealing section filed 1-7-2013 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2013, No. 2).
Note: Authority cited: Sections
					 25570.3
					 and
					 58004.5,
					 Health and Safety Code. Reference: Sections
					 25570-
					 25570.4,
					 Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 52 - Voluntary Registration of Environmental Assessors [Repealed] › Section 69212 - State Licensing Match System. [Repealed]

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
1. Change
				  without regulatory effect renumbering title 14, section
				  19042 to title 22, section
				  69212, including amendment of
				  section and NOTE, filed 7-27-2006 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2006, No. 30).
2. Change without regulatory
				  effect repealing section filed 1-7-2013 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2013, No. 2).
Note: Authority cited: Sections
					 25570.3
					 and
					 58004.5,
					 Health and Safety Code; section
					 11350.6,
					 Welfare and Institutions Code. Reference: Sections
					 25570-
					 25570.4,
					 Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 52 - Voluntary Registration of Environmental Assessors [Repealed] › Section 69213 - Limitations on Registration for Aliens. [Repealed]

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
1. Change
				  without regulatory effect renumbering title 14, section
				  19043 to title 22, section
				  69213, including amendment of
				  section and NOTE, filed 7-27-2006 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2006, No. 30).
2. Change without regulatory
				  effect repealing section filed 1-7-2013 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2013, No. 2).
Note: Authority cited: Sections
					 25570.3
					 and
					 58004.5,
					 Health and Safety Code. Reference: Sections
					 25570-
					 25570.4,
					 Health and Safety Code; 8
					 U.S.C. Sections 1621,
					 1641 and
					 1642.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 52 - Voluntary Registration of Environmental Assessors [Repealed] › Section 69214 - Sunset Review. [Repealed]

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
1. Change
				  without regulatory effect renumbering title 14, section
				  19044 to title 22, section
				  69214, including amendment of
				  section and NOTE, filed 7-27-2006 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2006, No. 30).
2. Change without regulatory
				  effect repealing section filed 1-7-2013 pursuant to section
				  100, title 1, California Code of
				  Regulations (Register 2013, No. 2).
Note: Authority cited: Sections
					 25570.3
					 and
					 58004.5,
					 Health and Safety Code. Reference: Sections
					 25570-
					 25570.4,
					 Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 1 - General › Section 69401 - Purpose and Applicability

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
Health and Safety Code section
					 25256.1
					 requires the Office of Environmental Health Hazard Assessment (hereafter
					 referred to as "OEHHA") "to evaluate and specify the hazard traits,
					 toxicological and environmental endpoints, and any other relevant data to be
					 included" in the Toxics Information Clearinghouse ("Clearinghouse") mandated
					 under Health and Safety Code section
					 25252
et seq
. The law envisions that the Clearinghouse will "provide
					 a decentralized, Web-based system for the collection, maintenance and
					 distribution of specific chemical hazard trait and environmental and
					 toxicological endpoint data." As such, it will provide basic scientific
					 information that will be available to agencies, the public, and industry and
					 government scientists and engineers evaluating chemicals in consumer products.
					 Health and Safety Code section
					 25252
					 requires the Department of Toxic Substances Control (hereafter referred to as
					 "Department" or "DTSC") to develop criteria for chemical evaluations that
					 include but are not limited to traits, characteristics and endpoints in the
					 Toxics Information Clearinghouse.
Chapter 54 specifies hazard traits, toxicological and
					 environmental endpoints, and other relevant data to be included in the
					 Clearinghouse as required by Health and Safety Code section
					 25256.1.
					 This information is intended for use pursuant to Health and Safety Code
					 sections
					 25252
					 et seq., Chapter 53 to division 4.5 of California Code of Regulations, Title
					 22.
1. New
					 chapter 54 (articles 1-7, sections
					 69401-69407.2), article 1
					 (sections 69401-69401.2) and section filed
					 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 1 - General › Section 69401.1 - Hazard Trait Framework

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
This Chapter and its components reflect a framework for
					 organizing information on chemical hazards for use by the Department in
					 implementing Health and Safety Code section
					 25252
					 et seq. This Chapter provides a structure for relating scientific information
					 to the hazard traits, and general guidance on whether or not a given chemical
					 exhibits a hazard trait based on the scientific evidence. The framework is
					 organized around four major categories of hazard traits: toxicological,
					 environmental, exposure potential and physical. Beneath each of these are
					 specific hazard traits, the major toxicities and adverse characteristics of
					 chemical substances. The toxicological and environmental hazard traits are
					 manifested as endpoints, which are the kinds of adverse health and
					 environmental effects observed in scientific studies. Other relevant data are
					 also included for the toxicological and environmental hazard traits. These data
					 can be observed through scientific study and provide less-direct but useful
					 evidence of the potential presence of a hazard trait. For exposure potential
					 and physical hazard traits, data from scientific studies can also be used to
					 determine the presence or absence of the hazard trait. A non-exclusive list of
					 additional relevant data that may be useful in evaluating chemicals is provided
					 in Article 7.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 1 - General › Section 69401.2 - Definitions

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) "Adverse
				  effect" for toxicological hazard traits and endpoints means a biochemical
				  change, functional impairment, or pathologic lesion that negatively affects the
				  performance of the whole organism, or reduces an organism's ability to respond
				  to an additional environmental challenge. "Adverse effect" for environmental
				  hazard traits and endpoints means a change that negatively affects an
				  ecosystem, community, assemblage, population, species, or individual level of
				  biological organization.
(b)
				  "Authoritative organization" means a state, national, international or
				  non-governmental entity whose scientific findings on the safety, risks or
				  hazards of chemical agents are relied upon by state, national or international
				  governments and their supporting public health or environmental entities in
				  regulating or otherwise protecting human health or the environment from threats
				  posed by those chemical agents. Authoritative organizations include the
				  following:
(1) OEHHA, DTSC and other State of
				  California Boards, Departments, Offices or Agencies
(2) The National Academy of Sciences,
				  including the National Research Council and the Institute of Medicine
(3) Departments or Agencies of the United
				  States government, including but not limited to: the Consumer Product Safety
				  Commission, Environmental Protection Agency, National Toxicology Program,
				  National Institute of Environmental Health Sciences, National Institutes of
				  Health, National Institute for Occupational Safety and Health, the Occupational
				  Safety and Health Administration, and the Department of
				  Transportation
(4) Environmental
				  and public health regulatory agencies of other states
(5) Canadian government agencies including
				  Environment Canada and Health Canada
(6) Governmental bodies within the European
				  Union, including the European Chemicals Agency and national
				  governments
(7) Any agency or
				  program within the United Nations including the World Health Organization and
				  its International Agency for Research on Cancer.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 2 - Toxicological Hazard Traits - Carcinogenicity, Developmental Toxicity, and Reproductive Toxicity › Section 69402 - General

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
This article specifies carcinogenicity, developmental
					 toxicity and reproductive toxicity hazard traits, endpoints and other relevant
					 data for these three traits.
1. New
					 article 2 (sections
					 69402-69402.6) and section filed
					 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 2 - Toxicological Hazard Traits - Carcinogenicity, Developmental Toxicity, and Reproductive Toxicity › Section 69402.1 - Carcinogenicity

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The
				  carcinogenicity hazard trait is defined as the occurrence of increased
				  incidence, reduced latency, or increased severity or multiplicity in neoplasia
				  following exposure to a chemical substance.
(b) Toxicological endpoints for
				  carcinogenicity include, but are not limited to those indicating malignant or
				  benign neoplasia or pre-neoplasia of alimentary, cardiovascular, endocrine,
				  genital, hematopoietic, integumentary, musculoskeletal, nervous, respiratory,
				  special senses, or urinary systems as well as any other systemic neoplastic
				  lesions observed in human or animal studies.
(c) Other relevant carcinogenicity data
				  include but are not limited to data on: mechanisms of carcinogenesis such as
				  exposure-related modifications to the physiology or response of cells, tissues
				  and organs (for example, mitogenesis, compensatory cell division, hyperplasia,
				  or signaling pathways used by cells to manage critical processes related to
				  increased risk for cancer); changes in key cellular structures at the molecular
				  level such as mutation and other genotoxicity endpoints; epigenetic changes
				  associated with increased cancer risk; structural similarity to other
				  carcinogenic chemical substances.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 2 - Toxicological Hazard Traits - Carcinogenicity, Developmental Toxicity, and Reproductive Toxicity › Section 69402.2 - Evidence for Carcinogenicity Hazard Trait

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) Each of the following constitutes strong
				  evidence of carcinogenicity for a given chemical substance:
(1) Identification as known to the state to
				  cause cancer in Title 27, California Code of Regulations, section
				  27001.
(2) Meeting the U.S. Environmental Protection
				  Agency's criteria for being identified as Carcinogenic to Humans or Likely to
				  Be Carcinogenic to Humans or as a Group A, B1 or B2 carcinogen.
(3) Meeting the International Agency for
				  Research on Cancer criteria for Group 1, 2A, or 2B classification.
(4) Meeting the criteria for classification
				  as known to be or reasonably anticipated to be a human carcinogen by the U.S.
				  National Toxicology Program.
(5)
				  Meeting the criteria for being classified as a Category 1 Known or Presumed
				  Carcinogen under the United Nation's Globally Harmonized System for
				  Classification and Labeling of Chemicals.
(6) Identification as or other recognition
				  that the chemical substance is a known or potential carcinogen in a report by
				  the National Academy of Sciences' National Research Council or Institute of
				  Medicine.
(7) Recognition as a
				  known or potential carcinogen by an authoritative
				  organization.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 2 - Toxicological Hazard Traits - Carcinogenicity, Developmental Toxicity, and Reproductive Toxicity › Section 69402.3 - Developmental Toxicity

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The
				  developmental toxicity hazard trait is defined as the occurrence of adverse
				  effects on the developing organism following exposure to a chemical substance
				  prior to conception (either parent), during prenatal development, or
				  postnatally to the time of sexual maturation. Developmental toxicity occurs
				  during the postnatal period only if the developing organism shows greater
				  quantitative or qualitative susceptibility to the chemical substance than does
				  the adult organism.
(b)
				  Toxicological endpoints for developmental toxicity include but are not limited
				  to those indicating: death of the developing organism, structural abnormality,
				  altered growth, functional deficiency or other adverse effect on the developing
				  organism. These observations in animals or humans can be manifested at any
				  point in the lifespan of the organism or its offspring.
(c) Other relevant data include, but are not
				  limited to: mechanistic data at the molecular level such as genotoxicity or
				  epigenetic toxicity, or at the cellular, organ, or organism level; structural
				  or mechanistic similarity to other chemical substances that are toxic to
				  developing organisms.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 2 - Toxicological Hazard Traits - Carcinogenicity, Developmental Toxicity, and Reproductive Toxicity › Section 69402.4 - Evidence for Developmental Toxicity Hazard Trait

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) Each of the following constitutes strong
				  evidence of developmental toxicity for a given chemical substance:
(1) Identification as known to the state to
				  cause reproductive toxicity with developmental toxicity denoted as an endpoint
				  in Title 27, California Code of Regulations, section
				  27001.
(2) Meeting the National Toxicology Program
				  criteria as having clear or sufficient evidence of adverse effects for
				  developmental toxicity.
(3) Meeting
				  the criteria for being classified as Category 1, known or presumed human
				  reproductive toxicant based on developmental toxicity data, under the United
				  Nation's Globally Harmonized System for Classification and Labeling.
(4) Identification in the National Institute
				  for Occupational Safety and Health's Pocket Guide to Chemical Hazards as having
				  teratogenic or other developmental effect.
(5) Identification as a known or potential
				  developmental toxicant or having the capacity to cause developmental toxicity
				  in a report published by the National Academy of Sciences' National Research
				  Council or Institute of Medicine.
(6) Identification as having sufficient
				  evidence of carcinogenicity by the International Agency for Research on Cancer,
				  with a clear statement that the chemical substance induces transplacental
				  carcinogenesis noted in an International Agency for Research on Cancer
				  Monograph on the Evaluation of Carcinogenic Risks to Humans.
(7) Recognition as a developmental toxicant
				  by an authoritative organization.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 2 - Toxicological Hazard Traits - Carcinogenicity, Developmental Toxicity, and Reproductive Toxicity › Section 69402.5 - Reproductive Toxicity

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The
				  reproductive toxicity hazard trait is defined as the occurrence of adverse
				  effects on the reproductive system or reproductive function of females or males
				  following exposure to a chemical substance.
(b) Toxicological endpoints for reproductive
				  toxicity include, but are not limited to: adverse alterations to the female or
				  male reproductive organs, the related endocrine system, or pregnancy outcomes;
				  adverse effects on onset of puberty, gamete production and transport,
				  reproductive cycle normality, sexual behavior, fertility, gestation,
				  parturition, or lactation; developmental toxicity, premature reproductive
				  senescence, or other modifications that compromise the integrity of the
				  reproductive system or reproductive function in animals or humans.
(c) Other relevant data include but are not
				  limited to: data on endocrine disruption, genotoxicity,
in
				  vitro
measures of the capacity of a chemical to damage the function or
				  structure of germ cells such as sperm or oocytes or cells critical for
				  reproductive function, such as Sertoli and Leydig cells in males; structural or
				  mechanistic similarity to other substances that are toxic to reproductive
				  systems.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 2 - Toxicological Hazard Traits - Carcinogenicity, Developmental Toxicity, and Reproductive Toxicity › Section 69402.6 - Evidence for Reproductive Toxicity Hazard Trait

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) Each of the following constitutes strong
				  evidence of reproductive toxicity for a given chemical substance:
(1) Identification as known to the state to
				  cause reproductive toxicity with male or female reproductive toxicity or both
				  denoted as an endpoint in Title 27, California Code of Regulations, section
				  27001.
(2) Meeting the National Toxicology Program
				  criteria as having clear or sufficient evidence of adverse effects for
				  reproductive toxicity.
(3) Meeting
				  the criteria for being classified as Category 1 for known or presumed effects
				  on human reproduction or on development based on male or female reproductive
				  toxicity data under the United Nations' Globally Harmonized System for
				  Classification and Labeling of Chemicals.
(4) Identification as a known or potential
				  male or female reproductive toxicant or both or having the capacity to cause
				  reproductive toxicity in a report by the National Academy of Sciences' National
				  Research Council or Institute of Medicine.
(5) Identification in the National Institute
				  for Occupational Safety and Health ("NIOSH") Pocket Guide to Chemical Hazards
				  with having reproductive organs as the target organ or as having sterility or
				  other reproductive effects.
(6)
				  Recognition as a reproductive toxicant by an authoritative
				  organization.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 3 - 3. Other Toxicological Hazard Traits › Section 69403 - General

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
This article specifies toxicological hazard traits and
					 endpoints and other relevant data for toxicological hazard traits that are not
					 otherwise addressed in Article 2 of this Chapter.
1. New
					 article 3 (sections
					 69403-69403.17) and section filed
					 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 3 - 3. Other Toxicological Hazard Traits › Section 69403.1 - Cardiovascular Toxicity

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The
				  cardiovascular toxicity hazard trait is defined as the occurrence of adverse
				  effects on the structure or function of the heart or the vascular system
				  following exposure to a chemical substance.
(b) Toxicological endpoints for
				  cardiovascular toxicity include but are not limited to observations indicating:
				  structural effects associated with cell necrosis, cellular degeneration,
				  proliferation, fibrosis, or inflammation of the heart or vasculature,
				  atherosclerosis, thickening of arterial walls, or cardiac hypertrophy;
				  functional effects such as arrhythmia or changes in rhythmicity or
				  contractility of the heart, hypo- or hyper- tension, decreased cardiac output,
				  alteration of vascular reactivity or vessel dilation or contraction; outcomes
				  of structural or functional impairment including high blood pressure,
				  myocardial infarct, or cardiac failure; epidemiological or laboratory animal
				  observations of cardiovascular morbidity or mortality in association with
				  chemical substance exposure.
(c)
				  Other relevant cardiovascular toxicity data include but are not limited to:
				  markers of systemic inflammation; alteration of the electrophysiology of
				  isolated cardiomyocytes; dysregulation of cytokines; platelet activation and
				  aggregation; perturbation of clotting; changes in cardiomyocytes gene
				  expression involved in heart disease; alterations of cell signaling related to
				  vascular or heart disease;
in vitro
measures of cardiovascular
				  toxicity such as cytotoxicity to isolated vascular endothelial cells;
				  structural or mechanistic similarity to other chemical substances that are
				  toxic to the cardiovascular system.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 3 - 3. Other Toxicological Hazard Traits › Section 69403.2 - Dermatotoxicity

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The
				  dermatotoxicity hazard trait is defined as the occurrence of adverse effects on
				  the structure or function of the skin including its barrier properties and its
				  ability to maintain heat, fluid, or electrolyte homeostasis following exposure
				  to a chemical substance.
(b)
				  Toxicological endpoints for dermatotoxicity include but are not limited to
				  those indicating: allergic sensitization, allergic reactions, acute or subacute
				  irritation, photosensitivity, or corrosivity measured in
in
				  vivo
and
in vitro
skin models.
(c) Other relevant dermatotoxicity data
				  include, but are not limited to:
in vitro
measures of
				  dermatotoxicity such as toxicity in cell-based models; structural or
				  mechanistic similarity to other chemical substances that are
				  dermatotoxic.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 3 - 3. Other Toxicological Hazard Traits › Section 69403.3 - Endocrine Toxicity

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The
				  endocrine toxicity hazard trait is defined as the occurrence of adverse effects
				  following exposure to a chemical substance on the structure or function of the
				  endocrine system, including endocrine disruption and metabolic
				  syndrome.
(b) Toxicological
				  endpoints for endocrine toxicity include but are not limited to those
				  indicating: adverse effects on endocrine organs; adverse perturbations of the
				  synthesis, secretion, transport, binding, action, or elimination of natural
				  hormones or their receptors in the body that are responsible for the
				  maintenance of homeostasis, metabolism, reproduction, development or
				  behavior.
(c) Other relevant data
				  include but are not limited to: binding of a chemical substance or its
				  metabolites to hormones or hormonal receptors or inhibition of hormone
				  synthesis
in vitro
experimental models; induction of hormone
				  metabolic enzymes; modulation of genes involved in metabolic syndrome;
				  structural or mechanistic similarity to other chemical substances that are
				  toxic to endocrine systems.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 3 - 3. Other Toxicological Hazard Traits › Section 69403.4 - Epigenetic Toxicity

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The
				  epigenetic toxicity hazard trait is defined as changes, at the cellular or
				  organism level, in gene expression or gene function that do not involve changes
				  in the DNA sequence and contribute to adverse effects in an organism following
				  exposure to a chemical substance.
(b) Toxicological endpoints for epigenetic
				  toxicity include, but are not limited to those indicating: toxicity in humans
				  or animals associated with epigenetic mechanisms such as chemically induced DNA
				  methylation, histone modification, nucleosome remodeling, or non-coding RNA.
				  Chemically induced epigenetic endpoints may be observed in an exposed organism
				  or its offspring.
(c) Other
				  relevant epigenetic toxicity data include but are not limited to:
in
				  vitro
or other data using biological models indicative of chemically
				  induced epigenetic toxicity in an exposed organism or its offspring; structural
				  or mechanistic similarity to other chemical substances that induce adverse
				  epigenetic effects.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 3 - 3. Other Toxicological Hazard Traits › Section 69403.5 - Genotoxicity

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) Genotoxicity is
				  defined as the occurrence of a chemical substance-induced change, either direct
				  or indirect, to the cellular genome, including DNA sequences or
				  chromosomes.
(b) Toxicological
				  endpoints for genotoxicity include but are not limited to those indicating: DNA
				  damage, mutations in genes, chromosomal aberrations, micronuclei, sister
				  chromatid exchange, aneuploidy, polyploidy, DNA adduct formation, or
				  unscheduled DNA synthesis in humans, animals, other organisms or cell
				  lines.
(c) Other relevant data
				  include but are not limited to: data on protein-adduct formation; electrophilic
				  potential; abasic sites; protein-DNA crosslinks; structural or mechanistic
				  similarity to other chemical substances that are genotoxic.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 3 - 3. Other Toxicological Hazard Traits › Section 69403.6 - Hematotoxicity

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The
				  hematotoxicity hazard trait is defined as the occurrence of adverse effects on
				  blood or blood-forming tissues following exposure to a chemical
				  substance.
(b) Toxicological
				  endpoints for hematotoxicity include, but are not limited to those indicating:
				  alterations in the number, types or lifetime of circulating blood cells, or in
				  the ratio of cell types; decrease in the oxygen transporting capacity of
				  hemoglobin or red blood cells; increase or decrease in blood clotting activity
				  resulting from interference in platelet response or function or other causes;
				  bone marrow toxicity; aplastic, hemolytic or myelodysplastic anemia.
(c) Other relevant data include but are not
				  limited to:
in vitro
measures of toxicity in isolated blood
				  cells or blood-forming tissues; structural or mechanistic similarity to other
				  chemical substances that are hematotoxic.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 3 - 3. Other Toxicological Hazard Traits › Section 69403.7 - Hepatotoxicity and Digestive System Toxicity

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The hepatotoxicity and digestive system
				  toxicity hazard trait is defined as the occurrence of adverse effects on the
				  structure or function of the liver, gall bladder, or gastrointestinal tract
				  following exposure to a chemical substance.
(b) Toxicological endpoints for
				  hepatotoxicity and digestive system toxicity include, but are not limited to
				  those indicating: liver damage; fatty liver; hepatitis; canicular cholestasis;
				  vascular changes; steatosis; bile duct damage; gall bladder disease;
				  gastrointestinal tract dysfunction including emesis and acid reflux disorder;
				  sinusoidal damage; cirrhosis; inflammation or hyperplasia of the
				  gastrointestinal epithelium.
(c)
				  Other relevant hepatotoxicity and gastrointestinal toxicity data include but
				  are not limited to those indicating: elevated pro-inflammatory cytokines,
				  induction or inhibition of xenobiotic metabolizing enzymes; generation of
				  reactive metabolites; disruption of glucose or glycogen metabolism; impaired or
				  unbalanced serum protein production; in vitro indicators of hepatotoxicity;
				  structural or mechanistic similarity to other chemical substances that are
				  hepatotoxic or cause digestive system toxicity.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 3 - 3. Other Toxicological Hazard Traits › Section 69403.8 - Immunotoxicity

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) Immunotoxicity
				  is defined as the occurrence of adverse effects on the components or function
				  of the immune system following exposure to a chemical substance.
(b) Toxicological endpoints for
				  immunotoxicity include but are not limited to those indicating: allergic
				  sensitization, those indicating hypersensitivity (types I-IV); changes in
				  circulating immune cell numbers; gross and histopathological changes in
				  lymphoid organs; alterations in cytokine production and release; changes in
				  number or behavior of regulatory effector cells;
in vivo
suppression or enhancement of the immune response; changes in specific
				  immunoglobulins; changes in immune organ weights;
in vitro
or
ex vivo
indicators of heightened or suppressed immune
				  response; initiation or exacerbation of autoimmunity.
(c) Other relevant immunotoxicity data
				  include but are not limited to: high antigenicity; structural or mechanistic
				  similarity to other chemical substances that are immunotoxic.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 3 - 3. Other Toxicological Hazard Traits › Section 69403.9 - Musculoskeletal Toxicity

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The
				  musculoskeletal toxicity hazard trait is defined as the occurrence of adverse
				  effects on the structure or function of the musculoskeletal system following
				  exposure to a chemical substance. The musculoskeletal system includes bones,
				  muscles, cartilage, tendons, ligaments, joints and connective tissue.
(b) Toxicological endpoints for
				  musculoskeletal toxicity include, but are not limited to those indicating:
				  necrosis, inflammation, discomfort or pain of the musculoskeletal system;
				  arthritis; decreased joint movement; changes in mineral content of bone
				  including tooth mottling; osteomalacia; osteoporosis; bone malformation or
				  other skeletal growth disorders; abnormal bone mass or density indices; tooth
				  loss; cell proliferation or altered ratio of musculoskeletal cells;
				  fibromyalgia; adverse muscle or neuromuscular function.
(c) Other relevant musculoskeletal toxicity
				  data include, but are not limited to:
in vitro
indicators of
				  musculoskeletal toxicity; structural or mechanistic similarity to other
				  chemical substances that are toxic to the musculoskeletal system.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.