California Code of Regulations › Title 27 - Environmental Protection › Division 4 - Office of Environmental Health Hazard Assessment › Chapter 1 - Safe Drinking Water and Toxic Enforcement Act of 1986 › Article 8 - NO Observable Effect Levels › Section 25805 - Specific Regulatory Levels: Chemicals Causing Reproductive Toxicity

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) Exposure to
				  a chemical at a level which does not exceed the level set forth in subsection
				  (b) for such chemical has no observable effect assuming exposure at one
				  thousand (1,000) times that level.
(b)
Chemical Name
Level (micrograms/day)
Acrylamide
140
Atrazine
100 (oral)
Avermectin B1
4.4
Benzene
24 (oral)
49 (inhalation)
Bisphenol A (BPA)
3 (dermal exposure from
solid materials)
Butyl Benzyl Phthalate (BBP)
1,200 (oral)
Cadmium
4.1 (oral)
Chlorpyrifos
0.58 (oral and inhalation)
Chlorpyrifos
7.2 (dermal)
Chromium (hexavalent compounds)
8.2 (oral)
Cyanide Salts that readily dissociate in solution
							 (expressed as cyanide)
9.8 (oral)
2,4-Diamino-6-chloro-
s
-triazine
							 (DACT)
100 (oral)
2,4-D butyric acid (2,4-DB, 2,4-dichlorophenoxybutyric
							 acid)
910
1,2-Dibromo-3-chloropropane (DBCP)
4.3 (inhalation)
3.1 (oral)
Des-ethyl atrazine (DEA)
100 (oral)
Des-isopropyl atrazine (DIA)
100 (oral)
Di(
n
-butyl)phthalate (DBP)
8.7
Di(2-ethylhexyl)phthalate (DEHP), for intravenous
							 exposures only
4200 (adults)
600 (infant boys, age 29 days-24 months)
210 (neonatal infant boys, age 0-28 days) [Levels for
							 male children and adolescents can be calculated by application of the default
							 bodyweights specified in Title 27, California Code of Regulations, Section
							 25703(a)(8) to
							 the procedure specified in Title 27, California Code of Regulations, Sections
							 25801 and
							 25803]
Di(2-ethylhexyl)phthalate (DEHP), for oral exposures
							 only
410 (adults)
58 (infant boys, age 29 days-24 months)
20 (neonatal infant boys, age 0-28 days) [Levels for
							 male children and adolescents can be calculated by application of the default
							 bodyweights specified in Title 27, California Code of Regulations, Section
							 25703(a)(8) to
							 the procedure specified in Title 27, California Code of Regulations, Sections
							 25801 and
							 25803]
Di-
n
-hexyl phthalate (DnHP)
2200 (oral)
Di-isodecyl phthalate (DIDP)
2200
m
-Dinitrobenzene
38 (oral)
Disodium cyanodithioimidocarbonate
56 (oral)
[170 (oral) as 32% pesticidal formulation]
Ethyl dipropylthiocarbamate
700 (oral and inhalation)
6700 (dermal)
Ethylene glycol (ingested)
8,700 (oral)
Ethylene glycol monoethyl ether (EGEE)
750 (oral)
960 (inhalation)
Ethylene glycol monoethyl ether acetate (EGEEA)
1100 (oral)
1400 (inhalation)
Ethylene glycol monomethyl ether
63 (oral)
Ethylene glycol monomethyl ether acetate
98 (oral)
Ethylene oxide
20
Hydramethylnon
120 (oral)
Hydrogen cyanide
10 (oral)
Lead
0.5
Linuron
460
Metham Sodium
290
Methanol
47,000 (inhalation)
23,000 (oral)
Methyl bromide as a structural fumigant
810 (inhalation)
n
-Hexane
28,000 (oral)
20,000 (inhalation)
N-Methylpyrrolidone
3200 (inhalation)
17000 (dermal)
Potassium dimethyldithiocarbamate
720
Potassium cyanide
25 (oral)
Propazine
100 (oral)
Quizalofop ethyl
590
Simazine
100 (oral)
Sodium cyanide
19 (oral)
Sodium dimethyldithiocarbamate
23 (oral) [58 (oral) as 40%
pesticidal formulation]
Sulfur dioxide
10000
Thiophanate-methyl
600 (oral)
Toluene
7000
(c)
				  Unless a specific level is otherwise provided in this section, an assessment by
				  an agency of the state or federal government that is the substantial equivalent
				  of the assessment described in subsection (a) of Section
				  25803, and establishes a maximum
				  allowable dose level in the manner provided in paragraph (b)(1) of Section
				  25801, shall constitute the
				  allowable dose level having no observable effect within the meaning of Section
				  25249.10(c) of
				  the Act.
1. New
					 section filed 2-24-88 as an emergency; operative 2-27-88 (Register 88, No. 11).
					 A Certificate of Compliance must be transmitted to OAL within 120 days or
					 emergency language will be repealed on 6-27-88.
2. New section
					 refiled 6-27-88 as an emergency; operative 6-27-88 (Register 88, No. 27). A
					 Certificate of Compliance must be transmitted to OAL within 120 days or
					 emergency language will be repealed on 10-25-88.
3. New section
					 refiled 10-17-88 as an emergency; operative 10-25-88 (Register 88, No. 44). A
					 Certificate of Compliance must be transmitted to OAL within 120 days or
					 emergency language will be repealed on 2-22-89.
4. New section
					 refiled 2-21-89 as an emergency; operative 2-22-89 (Register 89, No. 10). A
					 Certificate of Compliance must be transmitted to OAL within 120 days or
					 emergency language will be repealed on 6-22-89.
5. Certificate of
					 Compliance transmitted to OAL 6-9-89 and filed 7-10-89 (Register 89, No.
					 30).
6. Amendment of subsection (b) filed 4-9-92; operative 5-11-92
					 (Register 92, No. 15).
7. Amendment of subsection (b) filed
					 7-18-2002; operative 8-17-2002 (Register 2002, No. 29).
8. Amendment
					 of section heading and subsection (c) filed 1-7-2003; operative 2-6-2003
					 (Register 2003, No. 2).
9. Amendment of subsection (b) filed
					 2-25-2003; operative 3-27-2003 (Register 2003, No. 9).
10. Amendment
					 of section heading and subsection (b) filed 7-1-2003; operative 7-31-2003
					 (Register 2003, No. 27).
11. Amendment of section heading and
					 subsection (b) filed 12-23-2004; operative 1-22-2005 (Register 2004, No.
					 52).
12. Amendment of subsection (b) filed 8-12-2005; operative
					 9-11-2005 (Register 2005, No. 32).
13. Amendment of subsection (b)
					 filed 5-19-2006; operative 6-18-2006 (Register 2006, No. 20).
14.
					 Amendment of subsection (b) filed 8-3-2006; operative 9-2-2006 (Register 2006,
					 No. 31).
15. Amendment of subsection (b) filed 8-31-2007; operative
					 9-30-2007 (Register 2007, No. 35).
16. Change without regulatory
					 effect renumbering title 22, section
					 12805 to title 27, section
					 25805, including amendment of
					 subsection (c), filed 6-18-2008 pursuant to section
					 100, title 1, California Code of
					 Regulations (Register 2008, No. 25).
17. Amendment of subsection (b)
					 filed 6-23-2008; operative 7-23-2008 (Register 2008, No. 26).
18.
					 Amendment subsection (b) filed 12-2-2008; operative 1-1-2009 (Register 2008,
					 No. 49).
19. Amendment of subsection (b) filed 11-18-2010; operative
					 12-18-2010 (Register 2010, No. 47).
20. Amendment of subsection (b)
					 filed 12-16-2010; operative 1-15-2011 (Register 2010, No. 51).
21.
					 Amendment of subsection (b) filed 3-30-2011; operative 4-29-2011 (Register
					 2011, No. 13).
22. Amendment of subsection (b) filed 6-29-2011;
					 operative 7-29-2011 (Register 2011, No. 26).
23. Amendment of
					 subsection (b) filed 9-26-2011; operative 10-26-2011 (Register 2011, No.
					 39).
24. Amendment of subsection (b) filed 4-10-2013; operative
					 7-1-2013 (Register 2013, No. 15).
25. Amendment of subsection (b)
					 filed 6-25-2013; operative 10-1-2013 (Register 2013, No. 26).
26.
					 Amendment of subsection (b) filed 7-11-2013; operative 10-1-2013 (Register
					 2013, No. 28).
27. Amendment of subsection (b) filed 8-8-2013;
					 operative 10-1-2013 (Register 2013, No. 32).
28. Amendment of
					 subsection (b) filed 6-13-2016; operative 10-1-2016 (Register 2016, No.
					 25).
29. Change without regulatory effect amending subsection (b)
					 filed 7-27-2016 pursuant to section
					 100, title 1, California Code of
					 Regulations (Register 2016, No. 31).
30. Amendment of subsection (b)
					 filed 4-4-2017; operative 7-1-2017 (Register 2017, No. 14).
31.
					 Amendment of subsection (b) filed 5-3-2017; operative 7-1-2017 (Register 2017,
					 No. 18).
32. Amendment of subsection (b) filed 7-17-2018; operative
					 10-1-2018 (Register 2018, No. 29).
33. Amendment of subsection (b)
					 filed 3-11-2019; operative 7-1-2019 (Register 2019, No. 11).
34.
					 Amendment of subsection (b) filed 6-24-2020; operative 10-1-2020 (Register
					 2020, No. 26).
Note: Authority cited: Section
						25249.12,
						Health and Safety Code. Reference: Sections
						25249.5,
						25249.6,
						25249.9,
						25249.10
						and
						25249.11,
						Health and Safety Code.