reglab/statecodes huggingface dataset:
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 3 - 3. Other Toxicological Hazard Traits › Section 69403.10 - Nephrotoxicity and Other Toxicity to the Urinary System

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The nephrotoxicity hazard trait is
				  defined as the occurrence of adverse effects on the structure or function of
				  the kidney and other components of the urinary system following exposure to a
				  chemical substance.
(b)
				  Toxicological endpoints for nephrotoxicity and other urinary system toxicity
				  include, but are not limited to those indicating: abnormal urine volume or
				  chemistry; abnormal blood chemistry; alterations in glomerular filtration rate
				  or tubular re-absorptive capacity; pathological changes to the kidney;
				  formation of calculi in the ureter or bladder; muscular or epithelial damage in
				  the urinary bladder.
(c) Other
				  relevant data include, but are not limited to:
in vitro
indicators of nephrotoxicity; structural or mechanistic similarity to other
				  chemical substances that are nephrotoxic.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 3 - 3. Other Toxicological Hazard Traits › Section 69403.11 - Neurodevelopmental Toxicity

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The
				  neurodevelopmental toxicity hazard trait is defined as the occurrence of
				  adverse effects on development of the nervous system resulting from exposure to
				  a chemical substance during the developmental period, including effects on the
				  structure or function of the central or peripheral nervous system, such as
				  neurochemical, neurophysiological, neuroanatomical, or behavioral
				  alterations.
(b) Toxicological
				  endpoints for neurodevelopmental toxicity include but are not limited to:
				  alterations in neuromuscular, sensory, cognitive (learning and memory),
				  integrative or autonomic functions; neuropathological changes including gross
				  change in size or shape of the brain or brain regions, death of neuronal
				  precursors, abnormal proliferation, migration, differentiation, or alterations
				  in transient developmental structures, or hydrocephalus.
(c) Other relevant developmental
				  neurotoxicity data include but are not limited to evidence of neurotoxicity in
				  adult animals; in vitro indicators of toxicity such as in isolated neuronal
				  precursor cells or stem cells, or neurosphere models; structural or mechanistic
				  similarity to chemicals that are toxic to the developing nervous
				  system.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 3 - 3. Other Toxicological Hazard Traits › Section 69403.12 - Neurotoxicity

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The
				  neurotoxicity hazard trait is defined as the occurrence of adverse effects,
				  following exposure to a chemical substance, on the structure or function of the
				  central or peripheral nervous system, such as neurochemical,
				  neurophysiological, or behavioral effects.
(b) Toxicological endpoints for neurotoxicity
				  include, but are not limited to those indicating: pathological changes in the
				  central or peripheral nervous systems; abnormal electrical activity of the
				  central or peripheral nervous systems; altered neurochemical synthesis,
				  storage, secretion or uptake; impairments in neuromuscular control; mood
				  disorders; behavioral changes; impaired cognition including IQ
				  decrements.
(c) Other relevant
				  neurotoxicity data include but are not limited to:
in
vitro
indicators of neurotoxicity in isolated nervous system
				  cells; structural or mechanistic similarity to other chemical substances that
				  are neurotoxic.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 3 - 3. Other Toxicological Hazard Traits › Section 69403.13 - Ocular Toxicity

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The
				  ocular toxicity hazard trait is defined as the occurrence of adverse changes to
				  the components or function of the visual system following exposure to a
				  chemical substance.
(b)
				  Toxicological endpoints for ocular toxicity include but are not limited to
				  those indicating: damage to the iris, conjunctiva, lens or cornea; abnormal
				  reaction to light; damage to the eye lids or nictitating membranes; functional
				  or structural damage to the retina; damage to or induction of functional
				  abnormalities to the ocular portions of the central nervous system.
(c) Other relevant ocular toxicity data
				  include, but are not limited to physicochemical properties such as pH and
				  chemical reactivity; data on dermal irritancy or corrosivity; structural or
				  mechanistic similarity to other chemical substances that induce ocular
				  toxicity.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 3 - 3. Other Toxicological Hazard Traits › Section 69403.14 - Ototoxicity

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The ototoxicity
				  hazard trait is defined as the occurrence of adverse effects on the structure
				  or function of the inner ear or the vestibulo-cochlear nerve, or auditory
				  portions of the central nervous system, which could result in temporary or
				  permanent disturbances of hearing, balance, or both following exposure to a
				  chemical substance.
(b)
				  Toxicological endpoints for ototoxicity include, but are not limited to those
				  indicating: hearing impairment; abnormal balance; changes to cellular
				  components of the inner ear; change in auditory response or electrical activity
				  in the vestibulo-cochlear nerve or auditory areas of the brain.
(c) Other relevant ototoxicity data include
				  but are not limited to:
in vitro
indications of ototoxicity;
				  structural or mechanistic similarity to other chemical substances that are
				  ototoxic.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 3 - 3. Other Toxicological Hazard Traits › Section 69403.15 - Reactivity in Biological Systems

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The reactivity in biological systems
				  hazard trait is defined as the occurrence of rapid reactions with molecules in
				  the body that lead to alterations in critical molecular function and ultimately
				  adverse health outcomes.
(b)
				  Toxicological endpoints for reactivity in biological systems include, but are
				  not limited to: covalent binding to or oxidation of cellular macromolecules;
in vivo
generation of reactive oxygen species or oxidative
				  stress; catalytic generation of hydroxyl radicals
in
				  vivo
.
(c) Other relevant
				  data include, but are not limited to:
in vitro
measurements of
				  covalent binding to or oxidation of DNA, lipids or proteins; detection of
				  reactive species in cell culture; structural or mechanistic similarity to other
				  chemical substances that are reactive in biological systems.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 3 - 3. Other Toxicological Hazard Traits › Section 69403.16 - Respiratory Toxicity

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The
				  respiratory toxicity hazard trait is defined as the occurrence of adverse
				  effects on the structure or function of the respiratory tract following
				  exposure to a chemical substance, including respiratory tract injury or
				  decreased ability of the lungs to function in gas exchange.
(b) Toxicological endpoints for respiratory
				  toxicity include, but are not limited to those indicating: respiratory
				  irritation; pathological changes to the airway or other lung structures;
				  inflammation; fibrosis; hypersensitivity pneumonitis; airways
				  hyperresponsiveness; altered lung function; asthma; airways remodeling;
				  increased respiratory infections; altered composition of bronchoalveolar lavage
				  fluid.
(c) Other relevant data
				  include but are not limited to:
in vitro
evidence for
				  respiratory toxicity; particle size distribution inclusive of respirable
				  particles; respirable fibers; long half-life in the lung; chemical reactivity;
				  redox potential; structural or mechanistic similarity to other chemical
				  substances that are toxic to the respiratory system.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 3 - 3. Other Toxicological Hazard Traits › Section 69403.17 - Evidence for Other Toxicological Hazard Traits

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) For a given chemical substance, either of
				  the following constitutes strong evidence of any of the hazard traits
				  identified in this article:
(1) An
				  authoritative organization identifies or otherwise indicates that the chemical
				  substance has the hazard trait by:
(A)
				  Concluding based on well-conducted scientific studies that the chemical has the
				  hazard trait.
(B) Using the hazard
				  trait in a hazard identification, dose-response assessment or risk
				  assessment.
(C) Including the
				  chemical substance on a list of substances identified as having, or being
				  regulated based on, the hazard trait.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 4 - 4. Environmental Hazard Traits › Section 69404 - General

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
This article specifies environmental hazard traits and
					 endpoints and other relevant data for these traits.
1. New
					 article 4 (sections
					 69404-69404.10) and section filed
					 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 4 - 4. Environmental Hazard Traits › Section 69404.1 - Domesticated Animal Toxicity

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The domesticated animal toxicity hazard
				  trait is defined as the occurrence of adverse health effects on pets or
				  livestock from exposure to a chemical substance.
(b) Environmental endpoints for domesticated
				  animal toxicity include but are not limited to observations of reproductive or
				  developmental toxicity, morbidity or mortality of pets or livestock following
				  exposure to a chemical substance.
(c) Other relevant data include but are not
				  limited to endpoint data described in Articles 2 or 3 or Article 4 subsections
				  69404.6,
				  69404.7,
				  69404.8, or
				  69404.9 of this Chapter, showing
				  the potential for effects in a pet or livestock species.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 4 - 4. Environmental Hazard Traits › Section 69404.2 - Eutrophication

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The
				  eutrophication hazard trait is defined as contributing to adverse changes in
				  aquatic or soil ecosystems resulting from the release of excess chemical
				  nutrients or substances increasing the availability of nutrients. Observed
				  adverse changes typically include excessive plant growth, hypoxia in aquatic
				  systems and changes in species composition.
(b) Environmental endpoints for
				  eutrophication include, but are not limited to those indicating: excessive
				  plant growth; hypoxia; or changes in species composition following the release
				  of excess nutrients or substances increasing the availability of
				  nutrients.
(c) Other relevant data
				  include but are not limited to modeling to predict the impact of chemicals on
				  nutrient levels and plant growth in aquatic and terrestrial
				  ecosystems.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 4 - 4. Environmental Hazard Traits › Section 69404.3 - Impairment of Waste Management Organisms

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The impairment of waste management
				  organisms hazard trait is defined as adverse changes to biota relied upon in
				  aerobic and anaerobic sewage treatment and waste recycling.
(b) Environmental endpoints for impairment of
				  waste management organisms include but are not limited to: toxicity to
				  microorganisms, such as bacteria and algae, used in sewage treatment processes
				  or respiration inhibition of activated sludge following exposure to a chemical
				  substance.
(c) Other relevant data
				  include but are not limited to mechanistic or structural similarity to other
				  chemicals that impair waste management organisms.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 4 - 4. Environmental Hazard Traits › Section 69404.4 - Loss of Genetic Diversity, Including Biodiversity

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The loss of genetic diversity hazard
				  trait is defined as contributing to adverse change in the genetic make-up of a
				  species, community, assemblage or ecosystem following exposure to a chemical
				  substance.
(b) Environmental
				  endpoints for loss of genetic diversity, including biodiversity include, but
				  are not limited to those indicating: reduction in the abundance of species
				  within a community, assemblage or ecosystem, or the genetic make-up of local
				  populations in aquatic or terrestrial ecosystems.
(c) Other relevant data include but are not
				  limited to: in silico predictions of changes in genetic diversity; associative
				  data from field studies linking exposure to a chemical substance with changes
				  in genetic diversity or biodiversity.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 4 - 4. Environmental Hazard Traits › Section 69404.5 - Phytotoxicity

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The
				  phytotoxicity hazard trait is defined as the occurrence of adverse effects on
				  the reproduction, development, growth, function or survival of plants following
				  exposure to a chemical substance. For the purpose of this hazard trait,
				  "plants" mean vascular and nonvascular plants, algae, fungi and lichen present
				  in the aquatic and terrestrial environment, including harvested
				  species.
(b) Environmental
				  endpoints for phytotoxicity include, but are not limited to those indicating:
				  adverse effects on survival, fecundity, fertility, growth, abundance,
				  production, function or normal physiology in plants; gross developmental
				  anomalies.
(c) Other relevant
				  phytotoxicity impairment data include but are not limited to: mechanistic or
				  structural similarity to other phytotoxicants;
in
vitro
evidence of exposure-related adverse impacts in plants;
				  associative data from field studies linking exposure to a chemical substance
				  with observed phytotoxicity.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 4 - 4. Environmental Hazard Traits › Section 69404.6 - Wildlife Developmental Impairment

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The wildlife developmental impairment
				  hazard trait is defined as the occurrence of adverse effects on the structure
				  or function of the developing organism, including aquatic and terrestrial
				  organisms, following exposure to a chemical substance.
(b) Environmental endpoints for wildlife
				  development impairment include, but are not limited to those indicating:
				  malformations, exposure related adverse impacts on rate of development,
				  neurodevelopment, metamorphosis, or morphometrics in animal organisms,
				  including aquatic and terrestrial species.
(c) Other relevant developmental impairment
				  data include but are not limited to: mechanistic or structural similarity to
				  other chemical substances that impair wildlife development; data on mechanisms
				  of mammalian developmental toxicity as described for the toxicological hazard
				  traits in Article 2 subsection
				  69402.3 of this Chapter;
				  mechanistic data specific to non-mammalian wildlife; associative data from
				  field studies linking exposure to a chemical substance with adverse changes in
				  development.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 4 - 4. Environmental Hazard Traits › Section 69404.7 - Wildlife Growth Impairment

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The wildlife growth impairment hazard
				  trait is defined as the occurrence of adverse changes in absolute growth,
				  proportional growth or growth rate in organisms, including aquatic and
				  terrestrial organisms, following exposure to a chemical substance.
(b) Environmental endpoints for wildlife
				  growth impairment include, but are not limited to those indicating
				  abnormalities in growth rates or body size indices observed in animals,
				  including aquatic and terrestrial species.
(c) Other relevant growth impairment data
				  includes but are not limited to: mechanistic or structural similarity to other
				  chemicals that impair wildlife growth; mechanistically based markers of data on
				  growth retardation; associative data from field studies linking exposure to a
				  chemical substance with adverse changes in wildlife growth.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 4 - 4. Environmental Hazard Traits › Section 69404.8 - Wildlife Reproductive Impairment

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The wildlife reproductive impairment
				  hazard trait is defined as the occurrence of adverse effects on the
				  reproductive system or sexual function of wildlife, including aquatic and
				  terrestrial organisms, following exposure to a chemical substance that may
				  reduce reproductive capacity in the environment.
(b) Environmental endpoints for wildlife
				  reproductive impairment include, but are not limited to those indicating:
				  adverse changes in reproductive endocrine function, sexual maturation,
				  structure and function of reproductive organs, including intersex and imposex
				  organs, secondary sex characteristics, behavior related to reproduction such as
				  mating and parental care, vitellogenin production, fecundity, fertility, or
				  offspring sex ratio observed in the laboratory or in a wild population,
				  including aquatic and terrestrial species. Endpoints of toxicity described for
				  the toxicological hazard traits in Article 2 sections
				  69402.5 and
				  69403.3 of this Chapter are also
				  valid endpoints for wildlife reproductive impairment.
(c) Other relevant reproductive impairment
				  data include but are not limited to: mechanistic or structural similarity to
				  other chemical substances that impair wildlife reproduction;
in
				  vitro
evidence of exposure related perturbations of the
				  hypothalamic-pituitary-gonadal axis; agonism of the aryl hydrocarbon receptor;
				  binding or disruption of the function of the estrogen or androgen receptors;
				  toxicogenomic responses associated with reproductive impairment; other relevant
				  data as described for toxicological hazard traits in Article 2 section
				  69402.5 or Article 3 section
				  69403.3 of this Chapter;
				  associative data from field studies linking exposure to a chemical substance
				  with reductions in animal reproduction.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 4 - 4. Environmental Hazard Traits › Section 69404.9 - Wildlife Survival Impairment

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The wildlife survival impairment hazard
				  trait is defined as the occurrence of increased incidence of death, disease or
				  other biological impairment following exposure to a chemical substance that may
				  decrease the potential for wildlife survival, including in aquatic and
				  terrestrial species.
(b)
				  Environmental endpoints for wildlife survival impairment include, but are not
				  limited to those indicating: death; aquatic or terrestrial toxicity; toxicity
				  described for toxicological hazard traits in Articles 2 and 3 of this Chapter;
				  non-specific toxicity such as narcosis, behavioral impacts, increased disease
				  susceptibility, or changes in population viability observed in the laboratory
				  or in wild populations, including in aquatic and terrestrial species.
(c) Other relevant survival impairment data
				  include but are not limited to: structural or functional similarity to chemical
				  substances shown to impair wildlife survival;
in vitro
evidence described for toxicological hazard traits in Articles 2 and 3 of this
				  Chapter; data from
in vitro
testing designed specifically for
				  ecotoxicological endpoints; associative data from field studies suggesting a
				  possible link between a chemical and community or ecosystem level
				  impacts.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 4 - 4. Environmental Hazard Traits › Section 69404.10 - Evidence for Environmental Hazard Traits

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) For a given chemical substance, either of
				  the following constitutes strong evidence of any of the hazard traits
				  identified in this article:
(1) An
				  authoritative organization identifies or otherwise indicates that the chemical
				  substance has the hazard trait by:
(A)
				  Concluding based on well-conducted scientific studies that the chemical has the
				  hazard trait.
(B) Using the hazard
				  trait in a hazard identification, dose-response assessment, risk assessment, or
				  other scientific evaluation.
(C)
				  Including the chemical substance on a list of substances identified as having,
				  or being regulated based on, the hazard trait.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 5 - Exposure Potential Hazard Traits › Section 69405 - General

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
This article specifies exposure potential hazard
					 traits.
1. New
					 article 5 (sections
					 69405-69405.8) and section filed
					 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 5 - Exposure Potential Hazard Traits › Section 69405.1 - Ambient Ozone Formation

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a)
				  The ambient ozone formation hazard trait is defined as the capacity for
				  chemical substances, such as volatile organic compounds, to react outdoors in
				  the presence of ultraviolet light to generate ozone and other oxidants, or
				  indoors in the presence of visible light to produce ozone.
(b) Evidence for the ambient ozone formation
				  hazard trait includes but is not limited to: measurements of reactivity of the
				  chemical substance, such as the Maximal Reactivity Scale adopted by the
				  California Air Resources Board pursuant to Health and Safety Code section
				  41712.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 5 - Exposure Potential Hazard Traits › Section 69405.2 - Bioaccumulation

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The
				  bioaccumulation hazard trait is defined as the accumulation of a chemical
				  substance in the tissue of organisms through any route, including respiration,
				  ingestion, or dermal, including direct contact with contaminated water,
				  sediment, and pore water in the sediment, or through transfer up the food
				  chain.
(b) Evidence for the
				  bioaccumulation hazard trait includes but is not limited to: the identification
				  of a substance to be bioaccumulative by an authoritative organization; studies
				  which show bioaccumulation in human, domesticated animal, wildlife or plant
				  tissues; inhibition of an efflux transporter; transfer of the chemical up a
				  food web; a trophic magnification factor or biomagnification factor greater
				  than 1 in aquatic or terrestrial systems; for organic chemicals, a
				  bioaccumulation or bioconcentration factor greater than 1000; a log
				  octanol-water partition coefficient greater than or equal to 4, or a log
				  octanol-air partition coefficient greater than or equal to 5; results from
				  bioaccumulation models indicating potential for bioaccumulation; structural
				  similarity to other bioaccumulative chemicals.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 5 - Exposure Potential Hazard Traits › Section 69405.3 - Environmental Persistence

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a)
				  The environmental persistence hazard trait is defined as the propensity for a
				  chemical substance to remain in the environment for a long time period
				  subsequent to its release by resisting chemical and biological
				  degradation.
(b) Evidence for
				  environmental persistence includes but is not limited to: the identification of
				  a substance to be persistent by an authoritative organization; resistance to
				  degradation in wastewater treatment processes; half-lives in marine, fresh or
				  estuary water of greater than 40 to 60 days, in sediment of greater than 2
				  months, in ambient air of greater than 2 days, or in soil of greater than 2
				  months; structural similarity to other persistent chemicals.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 5 - Exposure Potential Hazard Traits › Section 69405.4 - Global Warming Potential

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a)
				  The global warming potential hazard trait is defined as the propensity for a
				  chemical substance to be a greenhouse gas, that is, to absorb infrared
				  radiation in the atmosphere and, thereby, contribute to the general warming of
				  the planet.
(b) Evidence for the
				  global warming hazard trait includes but is not limited to: measures of the
				  global warming potential which meet the criteria of the International Panel on
				  Climate Change as a global warming substance.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 5 - Exposure Potential Hazard Traits › Section 69405.5 - Lactational or Transplacental Transfer

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The lactational or transplacental
				  transfer hazard trait is defined as the ability of a chemical substance to
				  transfer from the mother's tissues into breast milk or across the
				  placenta.
(b) Evidence for
				  lactational or transplacental transfer includes but is not limited to:
				  measurement of the chemical substance in mother's milk or crossing the placenta
				  into fetal circulation or the chemical substance possessing physical-chemical
				  or pharmacokinetic properties associated with movement into mother's milk or
				  across the placenta.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 5 - Exposure Potential Hazard Traits › Section 69405.6 - Mobility in Environmental Media

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The mobility in environmental media
				  hazard trait is defined as the capacity of a chemical substance for rapid
				  movement in the environment.
(b)
				  Evidence for environmental mobility of a chemical substance includes, but is
				  not limited to: reports in the scientific literature of environmental mobility;
				  evidence of widespread contamination of the food chain or global distribution
				  or ubiquitousness in the environment; physicochemical characteristics
				  predisposing to ease of movement through environmental compartments such as
				  air, water, or soil.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 5 - Exposure Potential Hazard Traits › Section 69405.7 - Particle Size or Fiber Dimension

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The particle size or fiber dimension
				  hazard trait is defined as the existence of a chemical substance in the form of
				  small particles or fibers or the propensity to form into such small-sized
				  particles or fibers with use or environmental release.
(b) Evidence for the particle size or fiber
				  dimension hazard trait includes, but is not limited to: measures of particle
				  size less than or equal to 10 micrometers in mass median aerodynamic diameter
				  for inhalation exposure, or less than 10 micrometers in any dimension for
				  dermal or ingestion exposure, or fibers with a 3:1 aspect ratio and a width
				  less than or equal to 3 micrometers.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 5 - Exposure Potential Hazard Traits › Section 69405.8 - Stratospheric Ozone Depletion Potential

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) This hazard trait is defined as the
				  capacity for a chemical substance to deplete stratospheric ozone and, thereby,
				  contribute to higher levels of ultraviolet B radiation reaching the earth's
				  surface.
(b) Evidence for the
				  stratospheric ozone depletion hazard trait includes but is not limited to:
				  listing of a chemical substance in the Montreal Protocol or by the U.S.
				  Environmental Protection Agency pursuant to section
				  612(a) of the
				  Clean Air Act as a substance that depletes stratospheric ozone.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 6 - Physical Hazard Traits › Section 69406 - General

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
This article specifies physical hazard
					 traits.
1. New
					 article 6 (sections
					 69406-69406.3) and section filed
					 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 6 - Physical Hazard Traits › Section 69406.1 - Combustion Facilitation

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a)
				  The combustion facilitation hazard trait is defined as a hazard due to a
				  substance causing or contributing to the combustion of another
				  material.
(b) Evidence for this
				  hazard trait includes, but is not limited to: meeting the criteria for being an
				  oxidizing gas in section
				  2.4, oxidizing liquid in section
				  2.13, or oxidizing solid in
				  section 2.14 of the Globally Harmonized
				  System of Classification and Labeling of Chemicals.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 6 - Physical Hazard Traits › Section 69406.2 - Explosivity

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The explosivity
				  hazard trait is defined as a hazard that results from chemical reaction that
				  produces gas at such a temperature and pressure and at such a speed as to cause
				  damage to the surroundings.
(b)
				  Evidence for this hazard trait includes but is not limited to: meeting the
				  criteria for being an explosive in section
				  2.1 or for organic peroxide type A
				  or B in section
				  2.15 of the Globally Harmonized
				  System of Classification and Labeling of Chemicals.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 6 - Physical Hazard Traits › Section 69406.3 - Flammability

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
(a) The
				  flammability hazard trait is defined as hazards due to substances that ignite
				  or heat under certain conditions, causing burns or fire.
(b) Evidence for this hazard trait includes,
				  but is not limited to, meeting the definition of flammable aerosol, flammable
				  gas, flammable liquid, or flammable solid in 29 CFR, Occupational Safety and
				  Health Standards, Part 1910, subpart Z, Toxic and Hazardous Substances,
				  Standard number 1910.1200; meeting the criteria for being a flammable gas in
				  section 2.3, liquid in section
				  2.6, solid in section
				  2.7, or aerosol in section
				  2.3; pyrophoric liquid in section
				  2.9 or solid in section
				  2.10; self-reactive substance or
				  mixture in section
				  2.8; self-heating substance or
				  mixture in section
				  2.11; substance or mixtures which,
				  in contact with water, emit flammable gases in section
				  2.12; or types C through F organic
				  peroxides in section
				  2.15 of the Globally Harmonized
				  System of Classification and Labeling of Chemicals.
1. New
					 section filed 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.
California Code of Regulations › Title 22 - Social Security › Division 4.5 - Environmental Health Standards for the Management of Hazardous Waste › Chapter 54 - Green Chemistry Hazard Traits, Toxicological and Environmental Endpoints and Other Relevant Data › Article 7 - Additional Relevant Data › Section 69407 - General

Current through Register 2024 Notice Reg. No. 28, July 12, 2024
This Article identifies types of relevant data in addition
					 to those provided in Articles 2 through 6 of this Chapter that may be included
					 in the Toxics Information Clearinghouse and that can inform chemical
					 evaluations under Health and Safety Code section
					 25252.
1. New
					 article 7 (sections
					 69407-69407.2) and section filed
					 12-20-2011; operative 1-29-2012 (Register 2011, No.
					 51).
Note: Authority cited: Sections
						25256.1
						and
						59012,
						Health and Safety Code. Reference: Sections
						25256.1
						and
						59012,
						Health and Safety Code.