Conversation so far:
Who was Bill W.
married to?
Lois Burnham.
Did they have any kids?
Wilson met his wife Lois Burnham during the summer of 1913.
When did they get married?
the summer of 1913.
Where did he work?
Vermont National Guard.
When did he start struggling with alcoholism?
1916.
How did alcohol impact his life?
Wilson's constant drinking made business impossible and ruined his reputation.

Question: Did alcohol affect his marriage?
Self-contained rewrite: Did alcohol affect Bill W.'s marriage?