Conversation so far:
who brought the printing press for the first time to india in the mid 16th century?
Portuguese Missionaries brought the printing press to India in the mid 16th century.
where in India was the printing press first brought for the first time to India in the mid 16th century?
Goa

Question: when did operations begin?
Self-contained rewrite: when did printing press operations in India in the mid 16th century?