Conversation so far:
What was one of the first success in comics during the 1920's and 1930;s?
in 1921, Jimmy Frise, one of Ernest Hemingway's drinking buddies during the journalist's days in Toronto, sold Life's Little Comedies.
Who did he sell it to?
to the Toronto Star's Star Weekly.

Question: What was the most successful comic strip during that time?
Self-contained rewrite: What was the most successful comic strip during the 1920's?