Conversation so far:
what was drusilla's personality like?
Actress Juliet Landau said that when she first received the script, it indicated that Drusilla's accent could be British or American.
what accent did she have?
Though she never considered portraying Drusilla with a Southern American accent.
did she end up doing it?
as James Marsters had considered for Spike, she notes that invited comparisons with Blanche DuBois would also have been interesting.

Question: what was special about her appearance?
Self-contained rewrite: What was special about Juliet Landau's appearance as Drusilla?