Conversation so far:
What are some of Albrecht Dürer's masterworks?
Adam and Eve, The Martyrdom of the Ten Thousand, Virgin with the Iris, the altarpiece Assumption of the Virgin, and Adoration of the Trinity are some of Albrecht Dürer's masterworks.
Does Albrecht Dürer have more masterworks besides Adam and Eve, The Martyrdom of the Ten Thousand, Virgin with the Iris, the altarpiece Assumption of the Virgin, and Adoration of the Trinity?
Knight, Death, and the Devil, St. Jerome in his Study, and the much-debated Melencolia I are some more of Albrecht Dürer's masterworks.
Are Knight, Death, and the Devil, St. Jerome in his Study, and the much-debated Melencolia I by Albrecht Dürer  well known?
Yes they are Albrecht Dürer's three most famous engravings

Question: What is significant about Nuremberg?
Self-contained rewrite: What is significant about Nuremberg forAlbrecht Dürer's?