Conversation so far:
When was the Russian colonial period for the Alaska Natives?
Arriving from Siberia by ship in the mid-eighteenth century, Russians began to trade with Alaska Natives.
What did the Alaska Natives and the Russians trade during the Russian colonial period?
The Russians were primarily interested in the abundance of fur-bearing mammals on Alaska's coast, as stocks had been depleted by over hunting in Siberia.
What did the Alaska Natives and the Russians hunt during the Russian colonial period?
Rather than hunting the marine life, the Russians forced the Aleuts to do the work for them.
When did the Russian colonial period for Alaska Natives end?
The Russian colonial period for Alaska Natives ended when in 1867, after less than a month of negotiations, the United States accepted Emperor Alexander II's offer to sell Alaska.
What else is notable about the Russian colonial period for Alaska Natives besides the arrival of Russians, and the fur trade?
The most devastating effects from the Russian colonial period for Alaska Natives were from disease.

Question: What was the impact of this?
Self-contained rewrite: What was the impact of disease for Alaska Natives?