Conversation so far:
What conflict did he have with the Ottoman Empire?
The defeat of Hungary at the Battle of Mohacs in 1526 "sent a wave of terror over Europe." The Muslim advance in Central Europe was halted.
Why did it send a wave of terror over Europe?
The regular Ottoman fleet came to dominate the Eastern Mediterranean after its victories at Preveza in 1538 and Djerba in 1560.

Question: Did he have other conflicts with the empire?
Self-contained rewrite: Besides the defeat of Hungary at the Battle of Mohacs in 1526, did Charles V have other conflicts with the empire?