Conversation so far:
What year was Irving Thalberg born?
Thalberg was born in Brooklyn, to German Jewish immigrant parents.
Who were his parents?
Jewish immigrant parents, William and Henrietta (Haymann).
Did he have any siblings?
Shortly after birth, he was diagnosed with "blue baby syndrome," caused by a congenital disease that limited the oxygen supply to his heart.

Question: Did this impact him at all in life?
Self-contained rewrite: Did any issue impact Irving Thalberg at all in life?