Conversation so far:
who is ed who is edd and who is eddy
Three best friends who are the protagonists of the Ed, Edd n Eddy animated television series
who are the antagonists of Ed, Edd n Eddy?
The Kanker Sisters are the antagonists of Ed Edd n Eddy.

Question: who is the leader?
Self-contained rewrite: who is the leader of the Kanker sisters?