Conversation so far:
Was John Dee married?
Dee was married three times.
did John Dee have children?
Dee had eight children
who was John Dee's first wife?
He first married Katherine Constable in 1565
who was John Dee's second wife?
His second (also childless) marriage to an unknown woman lasted only a year until her death in 1576.

Question: did they have children?
Self-contained rewrite: did John Dee in his second marriage to an unkown woman have children?