Conversation so far:
what was the name of the country charles v had the most issue with?
From 1515 to 1523, Charles's government in the Netherlands also had to contend with the rebellion of Frisian peasants.
what year did he have his conflict with his nemisis?
The rebels were initially successful but after a series of defeats, the remaining leaders were captured and decapitated in 1523.
did France concur Milan?
The outcome was that France relinquished its ancient claim on Flanders in 1528.

Question: what year was the final war? Who was in it?
Self-contained rewrite: In which year was the final war? who  were the  participants?