Conversation so far:
what economic and political changes took place during the colonization
The Spanish monarchy dominated society, trade and economic opportunities, and in consequence, political institutions became weaker and the economy declined.
Who was the Spanish queen during the colonization
Ferdinand of Aragon and Isabella of Castile created a personal union that most scholars view as the foundation of the Spanish monarchy.

Question: When did the queen's reign start
Self-contained rewrite: When did Queen Isabella of Spain's reign start