Conversation so far:
What happened to Charles V in Burgundy?
In 1506, Charles inherited his father's Burgundian territories, most notably the Low Countries and Franche-Comté.
Which territories were included in Charles V inheritance of Burgundian territories?
Most notably Charles inherited the Low Countries and Franche-Comté.
Did any conflict arise because of Charles V's inherited Burgundian territories?
Charles's aunt Margaret of Austria found herself at war with France over the question of Charles' requirement to pay homage to the French king for Flanders.

Question: Who was she?
Self-contained rewrite: Who was she that acted as regent for Charles V until 1515?