Conversation so far:
When did Rick Santorum get into politics?
Rick Santorum first became actively involved in politics in the 1970s through volunteering for Senator John Heinz, a Republican from Pennsylvania.
What role was Rick Santorum in 1995?
Rick Santorum served in the United States Senate representing Pennsylvania from 1995 to 2007.
What was Rick Santorum's first notable accomplishment as a senator?
In 1996, Rick Santorum served as Chairman of the Republican Party Task Force on Welfare Reform, and contributed to legislation that became the Personal Responsibility and Work Opportunity Act.
What was Rick Santorum's margin of victory on re-election as senator?
Rick Santorum was first elected to the Senate representing Pennsylvania during the 1994 Republican takeover. He was reelected in 2000, defeating U.S. Congressman Ron Klink by a 52–46% margin.
What about the next re-election for senator after 2000 for Rick Santorum? What was the margin of victory?
In Rick Santorum's reelection bid of 2006, he lost to Democrat Bob Casey, Jr. by a 59–41% margin.

Question: Were there particular issues that caused him to lose?
Self-contained rewrite: Were there particular issues that caused Rick Santorum to lose his 2006 senate reelection bid?