Conversation so far:
What was the most profitable fur at the beginning of the 18th century in the North American fur trade?
At the beginning of the 18th century, more organized violence than in previous decades occurred between the Native Americans involved in the deerskin trade and white settlers.
What happened as a result of the organized violence between Native Americans and white settlers at the beginning of the 18th century in the North American fur trade?
More organized violence than in previous decades occurred between the Native Americans involved in the deerskin trade and white settlers, most famously the Yamasee War.
What impact did the Yamasee War and other fighting have on the North American fur trade?
This uprising of Indians against fur traders almost wiped out the European colonists in the southeast.
Did the North American fur trade suffer as a result of European colonists almost being wiped out in the southeast?
Were any other furs besides deer fur important during the beginning of the 18th century in the southeastern North American fur trade?
Is there anything interesting I should know about the fur trade during the beginning of the 18th century in the southeastern North American fur trade?
Due to allying with the British during the Yamasee War, the Cherokees lacked Indian trading partners and could not break with Britain to negotiate with France or Spain.

Question: What happened to the fur trade after the Cherokees couldn't break with Britain?
Self-contained rewrite: What happened to the southeastern North American fur trade after the Cherokees couldn't break with Britain in the beginning of the 18th century?