Conversation so far:
What happened in France during Charles V's reign?
Much of Charles's reign was taken up by conflicts with France, which found itself encircled by Charles's empire while it still maintained ambitions in Italy.
Conflicts with France during Charles V's reign were over what?
Charles allied with England and Pope Leo X against the French and the Venetians, and was highly successful, driving the French out of Milan.
What is the most important fact in this article about Charles V and the Holy Roman Empire?
What was Charles V's greatest accomplishment?
Who did Charles V work with?
Charles allied with England and Pope Leo X against the French and the Venetians.
Did Charles V ally himself?
Charles allied with England and Pope Leo X against the French and the Venetians.

Question: What happened with the English Reformation?
Self-contained rewrite: What happened with Charles V in the English Reformation?