Conversation so far:
What is Pinky an the Brain about?
of every episode involves one of Brain's plans for world domination with Pinky's assistance and the ultimate failure of that plan.
Where does the show take place?
in historical times.
Who is the show about?
one of Brain's plans for world domination with.

Question: How does he try to take over the world?
Self-contained rewrite: How does Brain try to take over the world?