Conversation so far:
What year did Lionel Messi retire?
Lionel Messi's first retirement was June 26, 2016.
Why did Lionel Messi retire?
Lionel Messi, who had missed his penalty in the shootout, announced his retirement from football. He stated, I tried my hardest. The team has ended for me, a decision made.“
Did Lionel Messi ever come out of retirement?
On 12 August, it was confirmed that Lionel Messi had reversed his decision to retire from international football. He was included in the Argentina team's upcoming 2018 World Cup qualifiers.
Did Argentina lose when Lionel Messi missed the penalty goal during The Copa América Centenario Final?
Argentina lost to Chile on penalties after a 0–0 deadlock, resulting in Lionel Messi's third consecutive defeat in a major tournament final with Argentina, and his fourth overall.

Question: Was this loss in a major tournament?
Self-contained rewrite: Was the Copa América Centenario Final loss in a major tournament?