Conversation so far:
Did Isabella live in Granada?
It is unclear if Isabella I of Castile lived in Granada, but she definitely had a love for the land and was eventually entombed there.
Who were Isabella I of Castile and King Ferdinand II fighting against to conquer Granada?
Isabella I of Castile and King Ferdinand II fought against the Emirate of Granada, who had been held by the Muslim Nasrid dynasty since the mid-13th century.
Were Queen Isabella and King Ferdinand II able to conquer Granada?
On 2 January 1492 Isabella I of Castile and Ferdinand entered Granada to receive the keys of the city, and the principal mosque was reconsecrated as a church.

Question: What did they do to reorganize the empire?
Self-contained rewrite: What did Queen Isabella and King Ferdinand II do to reorganize the Granada empire?