Conversation so far:
What is Pinky an the Brain about?
of every episode involves one of Brain's plans for world domination with Pinky's assistance and the ultimate failure of that plan.
Where does the show take place?
in historical times.
Who is the show about?
one of Brain's plans for world domination with.
How does he try to take over the world?
world: in the end, a group of people vote that he should take over the world on the one day he does not want to.

Question: Where do they live?
Self-contained rewrite: Where do Pinky and the Brain live?