I replaced a Harmony 720 with the Harmony One. Since the 720 was not going to be used any longer, I used the replace remote button in the software. It transferred the account over to the Harmony One and loaded all the settings, Almost. It did not transfer any of the additional buttons I had defined for the previous remote or the "favorite channels" settings. This meant a fair amount of reprogramming.Other than that, I really like the new remote. It does everything well, the buttons feel good, and I like most of the layout. The touch screen, while very responsive, cannot be used by touch, like the older 720 screen could. On the 720 there were 3 buttons on each side of the screen, and this was much easier to do by touch.The range of the IR signal seems to be very good, and I don't have to point it directly at the Home theater setup, like I had to do with the 720.Overall I think the Harmony One is a great remote. 

Question: Which button we have to push to start the device?
Answer: I used the replace remote button in the software