Sam sits on the edge of his bed and tugs Dean 's hands away , and Dean thrashes , flinging an arm out to hit him , eyes wide and scared in the dim light of the motel room . Dean twists away with a panicked whimper , bedsheets crumpled and snaked around his waist and legs . His fingers dig and scrabble across them , legs kicking against the constraints of the fabric . Sam whispers nonsense syllables and meaningless words into the thin air between them , petting Dean down like a spooked colt .

Question: What may be the reason Sam is in a hotel room with Dean , flipping out ?
Answer: None of the above choices .Dean called Sam and asked him to come over and take him to a motel .Dean is going through major withdrawals and Sam is trying to help him through it .Sam is practicing for a part in a movie , a man who is tied to a bed and going crazy .