When you give the player a rare but powerful item which can only be used once but is never really required to proceed, most players will not use it at all, because they are waiting for the perfect moment. But even when this moment comes, they will still be reluctant to use it, because there might be an even better moment later. So they keep hoarding it for a moment which will never come. 

In the end, they will carry the item around until it is outclassed by other, more readily available resources, or even until the very end of the game. That means that such one-shot items don't provide any gameplay-value at all. They are simply too awesome to use.

What can you do to encourage the player to make use of their one-shot items and not hoard them?


Question: Will leaving corpses lying around upset my prisoners?
Answer: There is no consequence for leaving corpses anywhere. All it does if leave a mark of failure in your path of making a fully functional prison.