**[ 18 F]Ftordezoksiglyukoza** (xalqaro patentlanmagan nomi (INN)) yoki **ftrodezoksiglyukoza F18** ( (USAN va USP) ), shuningdek, odatda **ftordezoksiglyukoza** deb ataladi va qisqartirilgan {\displaystyle [^{18}F]FDG}**,** {\displaystyle 2[^{18}F]FDG} yoki {\displaystyle FDG}, radiofarmatsevtik preparat, pozitron emissiya tomografiyasi (PET) tibbiy tasvirlash usulida ishlatiladigan maxsus radioindikator. Kimyoviy jihatdan u {\displaystyle 2-deoksi-2-[^{18}F]ftoro-D-glyukoza}, glyukoza analogi bo'lib, glyukoza molekulasidagi C-2 pozitsiyasida normal gidroksil guruhi o'rniga pozitron chiqaradigan ftor-18 radionuklidiga ega.

{\displaystyle [^{18}F]FDG} ning to'qimalar tomonidan o'zlashtirilishi glyukozaning to'qimalarda o'zlashtirilishining ko'rsatkichi bo'lib, bu o'z navbatida to'qimalar metabolizmining ayrim turlari bilan chambarchas bog'liqdir. Bemorga {\displaystyle [^{18}F]FDG} yuborilgandan so'ng, PET skaneri tanadagi {\displaystyle [^{18}F]FDG} [tarqalishining ikki o'lchovli yoki uch o'lchovli tasvirlarini yaratishi mumkin.

1976 yilda ishlab chiqilganidan beri {\displaystyle [^{18}F]FDG} nevrologiya sohasidagi tadqiqotlarga katta ta'sir ko'rsatdi.  1980 yilda {\displaystyle [^{18}F]FDG}ning o'smalarda to'planishi haqidagi keyingi kashfiyot PETning saraton tashxisida asosiy klinik vosita sifatida evolyutsiyasini yaratdi.  {\displaystyle [^{18}F]FDG} hoirgi kunda PET neyrotasvirini olish va saraton kasalligini davolash uchun ishlatiladigan standart radiofarmasevtik preparat hisoblanadi. 

Tasvirlar turli xil tibbiy holatlarga tashxis qo'yish uchun yadro tibbiyot shifokori yoki rentgenolog tomonidan baholanishi mumkin.

Tarix
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1968 yilda chexoslavakiyadagi Karlova universitetining Organik kimyo kaferda doktori Yozef Pasak, Zdenek Tochik va Miloslav Cherniy FDG sintezini birinchi bo'lib tasvirladilar.  Keyinchalik, 1970-yillarda Brukxaven milliy laboratoriyasida Tatsuo Ido va El Vulf birinchi bo'lib ftor-18 bilan belgilangan FDG sintezini tasvirlab berishdi.  Birikmani birinchi marta 1976 yil avgust oyida Pensilvaniya universitetida Abass Alaviy tomonidan ikki oddiy inson ko'ngillilariga kiritilgan. Oddiy (PET emas) yadroviy skaner yordamida olingan miya tasvirlari ushbu organdagi {\displaystyle [^{18}F]FDG} kontsentratsiyasini ko'rsatdi (quyida tarix ma'lumotiga qarang).

1990 yil avgust oyidan boshlab va 1991 yil davomida FDG uchun xom ashyo bo'lgan kislorod-18 ning yetishmasligi izotop zaxiralarini ratsionga kiritish zaruratini tug'dirdi. Isroilning kislorod-18 zavodi Fors ko'rfazi urushi tufayli yopildi va AQSh hukumati Los Alamos milliy laboratoriyasidagi uglerod, kislorod va azot izotoplari zavodini yopdi va Isotecni asosiy yetkazib beruvchi sifatida qoldirdi.

Yana qarang
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* Ftorodopa

Foydalanilgan adabiyotlar ro'yxati
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1. ↑  "Determination of regional cerebral function with FDG-PET imaging in neuropsychiatric disorders". *Seminars in Nuclear Medicine* **32** (1): 13–34. January 2002. doi:10.1053/snuc.2002.29276. PMID 11839066.
2. ↑  "A fluorinated glucose analog, 2-fluoro-2-deoxy-D-glucose (F-18): nontoxic tracer for rapid tumor detection". *Journal of Nuclear Medicine* **21** (7): 670–5. July 1980. PMID 7391842. .
3. ↑  "Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug development". *Clinical Cancer Research* **11** (8): 2785–808. April 2005. doi:10.1158/1078-0432.CCR-04-2626. PMID 15837727.
4. ↑  "Synthesis of 2-Deoxy-2-fluoro-D-glucose". *Journal of the Chemical Society D: Chemical Communications* (2): 77. 1969. doi:10.1039/C29690000077.
5. ↑  "Labeled 2-deoxy-D-glucose analogs: 18F-labeled 2-deoxy-2-fluoro-D-glucose, 2-deoxy-2-fluoro-D-mannose and 14C-2-deoxy-2-fluoro-D-glucose". *J Labeled Compounds Radiopharm* **24** (2): 174–183. 1978. doi:10.1002/jlcr.2580140204.
6. ↑  „Shortage of FDG raw material threatens expanded use of PET".  DiagnosticImaging (21-oktabr 1992-yil).

Havolalar
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* „Fludeoxyglucose F 18". *Drug Information Portal*.  U.S. National Library of Medicine.

Andoza:Radiopharmaceuticals