Functional areas of the cerebral cortex.
The comparison of brain sizes
The brain with a hand
The **brain** is the part of the body which lets living beings think. It does some bodily functions, such as telling the rest of the body what to do. 

It gets input from sense organs, and changes behavior in response to this information. In humans, the brain also controls our use of language, and is capable of abstract thought. The brain is the main control centre of the whole body. The brain is made up of special cells called nerves, which are connected with each other and with other nerves in our body. 

In all animals, the brain is protected in some way. In ourselves, and all vertebrates, it is protected by the bones of the skull. In woodpeckers, the brain is protected by the tongue, which wraps around the brain.

Function
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The brain does the thinking, learning, and feeling for the body. For humans, it is the source of consciousness. The brain also controls basic autonomic body actions, like breathing, digestion, heartbeat, that happen automatically. These activities, and much else, are governed by unconscious functions of the brain and nervous system. All the information about the world gathered by our senses is sent through nerves into the brain, allowing us to see, hear, smell, taste, and feel things. The brain processes this information, and we experience it as pictures, sounds, and so on. The brain also uses nerves to tell the body what to do, for example by telling muscles to move or our heart to beat faster.

This is generally true but some activity is caused by the spinal cord directly, for example, reflex actions do not involve the brain. In lower animals, a good deal is done without their brain being involved. 

All vertebrates have brains and, over time, their brains have evolved to become more complex. Some simple animals, however, like sponges, do not have anything like a brain. Segmented invertebrates have ganglions in each segment, and a ring of nervous tissue around the alimentary canal at the front. This acts to bring sense data from the front into play with the movement of the body.

Parts
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In mammals, the brain is made of three main parts: the cerebrum, the cerebellum, and the brainstem. The surface of the cerebrum is the cerebral cortex, which all vertebrates have. Mammals also have an extra layer, the neocortex. This is the key to the behaviour which is typical of mammals, especially humans.

### Cerebral cortex

The cortex has sensory, motor, and association areas. The sensory areas are the areas that get and process information from the senses. The motor areas control voluntary movements, especially fine movements performed by the hand. The right half of the motor area controls the left side of the body, and vice versa. Association areas produce a meaningful experience of the world and supports abstract thinking and language. This enables us to interact effectively. Most connections are from one area of the cortex to another, rather than to subcortical areas; The figure may be as high as 99%.

### Thalamus

The thalamus puts together the input from most of the senses. It is the place in the brain which makes the "picture" we have of the world outside us. The thalamus sits centrally under the cerebral cortex.

### Cerebellum

The cerebellum coordinates muscles so they work together. It is also the centre of keeping position and balance, and motor skills. It is one of the most ancient parts of the brain and sits at the back underneath the cerebral cortex.

### Brain stem

The brain stem is at the back of the brain (actually underneath it in humans). It joins the rest of the brain with the spinal cord. It has lots of different parts that control different jobs in the body: for instance, the brain stem controls breathing, heartbeat, sneezing, eye blinking, and swallowing. Body temperature and hunger are also controlled by parts of the brain stem. Roughly speaking, it deals with the more automated aspects of nervous function.

Size
----

The volume of the human brain (relative to the size of the whole body) is very large, compared to that of most other animals. The human brain also has a very large surface (called cortex) for its size, which is possible because it is very wrinkled. If the human cortex were flattened, it would be close to a square meter in area. Some other animals also have very wrinkled brains, such as dolphins and elephants. Here is a rule of thumb: the larger an animal is, the larger its brain will be.p15 Even allowing for that, the human brain, and in particular the neocortex, is very large. We know it increased in size *four-fold* over the last several million years of evolution.p79 There are ideas about why this happened, but no-one is quite sure. Most theories suggest complex social activity and the evolution of language would make a larger brain advantageous.p80 As an additional note, Einstein's brain weighed only 1,230 grams, which is less than the average adult male brain (about 1,400 grams). The detailed organisation of a brain obviously matters, but in ways which are not understood at present.

### Number of cells

A human brain accounts for about 2% of the body's weight, but it uses about 20% of its energy. It has about 50–100 billion nerve cells (also called neurons), and roughly the same number of support cells, called *glia*. The job of neurons is to receive and send information to and from the rest of the body, while glia provide nutrients and guide blood flow to the neurons, allowing them to do their job. Each nerve cell has contact with as many as 10,000 other nerve cells through connections called synapses.

Related pages
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Neural signaling in the human brain. Small electrical charges go from one neuron to the next
* Spinal cord
* Vertebrate brain
* Human Connectome Project
* Thalamus

Other websites
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Wikimedia Commons has media related to ***Brain***.

* Sylvius: 400+ structure neuroanatomical visual glossary; used by over half of U.S. medical schools
* High-resolution cytoarchitectural primate brain atlases
* Kolata, Gene 2013. *The New York Times*. In a first, experiment links brains of two rats February 28, 2013
* Pais-Vieira, Miguel *et al* 2013. *Nature* Scientific Reports **3**, #1319. A brain-to-brain interface for real-time sharing of sensorimotor information doi:10.1038/srep01319

| * v
* t
* e
Diseases of the nervous system, primarily CNS |
| --- |
| Inflammation | 

|  |  |
| --- | --- |
| Brain | 
* Encephalitis
	+ Viral encephalitis
	+ Herpesviral encephalitis
	+ Limbic encephalitis
	+ Encephalitis lethargica
* Cavernous sinus thrombosis
* Brain abscess
	+ Amoebic

 |
| Brain and spinal cord | 
* Encephalomyelitis
	+ Acute disseminated
* Meningitis
* Meningoencephalitis

 |

 |
| Brain/encephalopathy | 

|  |  |  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- | --- | --- |
| Degenerative | 

|  |  |
| --- | --- |
| Extrapyramidal andmovement disorders | 
* Basal ganglia disease
	+ Parkinsonism
		- PD
		- Postencephalitic
		- NMS
	+ NBIA
		- PKAN
	+ Tauopathy
		- PSP
	+ Striatonigral degeneration
	+ Hemiballismus
	+ HD
	+ OA

* Dyskinesia
	+ Dystonia
		- Status dystonicus
		- Spasmodic torticollis
		- Meige's
		- Blepharospasm
	+ Athetosis
	+ Chorea
		- Choreoathetosis
	+ Myoclonus
		- Myoclonic epilepsy
	+ Akathisia

* Tremor
	+ Essential tremor
	+ Intention tremor
* Restless legs
* Stiff-person

 |
| Dementia | 
* Tauopathy
	+ Alzheimer's
		- Early-onset
	+ Primary progressive aphasia
* Frontotemporal dementia/Frontotemporal lobar degeneration
	+ Pick's
* Lewy bodies dementia
* Posterior cortical atrophy

* Vascular dementia

 |
| Mitochondrial disease | 
* Leigh syndrome

 |

 |
| Demyelinating | 
* Autoimmune
* Inflammatory
* Multiple sclerosis
* For more detailed coverage, see Template:Demyelinating diseases of CNS

 |
| Episodic/paroxysmal | 

|  |  |
| --- | --- |
| Seizures and epilepsy | 
* Focal
* Generalised
* Status epilepticus
* For more detailed coverage, see Template:Epilepsy

 |
| Headache | 
* Migraine
* Cluster headache
* Tension
* For more detailed coverage, see Template:Headache

 |
| Cerebrovascular | 
* TIA
* Stroke
* For more detailed coverage, see Template:Cerebrovascular diseases

 |
| Other | 
* Sleep disorders
	+ For more detailed coverage, see Template:Sleep

 |

 |
| CSF | 
* Intracranial hypertension
	+ Hydrocephalus
	+ Normal pressure hydrocephalus
	+ Choroid plexus papilloma
	+ Idiopathic intracranial hypertension
* Cerebral edema
* Intracranial hypotension

 |
| Other | 
* Brain herniation
* Reye syndrome
* Hepatic encephalopathy
* Toxic encephalopathy
* Hashimoto's encephalopathy
* Static Encephalopathy

 |

 |
| Both/either | 

|  |  |  |  |  |  |
| --- | --- | --- | --- | --- | --- |
| Degenerative | 

|  |  |
| --- | --- |
| SA | 
* Friedreich's ataxia
* Ataxia–telangiectasia

 |
| MND | 
* *UMN only:*
	+ Primary lateral sclerosis
	+ Pseudobulbar palsy
	+ Hereditary spastic paraplegia

* *LMN only:*
	+ Distal hereditary motor neuronopathies
	+ Spinal muscular atrophies
		- SMA
		- SMAX1
		- SMAX2
		- DSMA1
		- Congenital DSMA
		- Spinal muscular atrophy with lower extremity predominance (SMALED)
			* SMALED1
			* SMALED2A
			* SMALED2B
		- SMA-PCH
		- SMA-PME
	+ Progressive muscular atrophy
	+ Progressive bulbar palsy
		- Fazio–Londe
		- Infantile progressive bulbar palsy

* *both:*
	+ Amyotrophic lateral sclerosis

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 |

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This is CRAP