|  |  |
| --- | --- |
|  | **Cave: notitiae huius paginae nec praescriptiones nec consilia medica sunt.** |

**Venlafaxinum**| Cognitores |
| --- |
| *ChemSpider* | 5454 |
| PubChem | 5656 |
| DrugBank | DB00285 |
| Natura chemica |
| Venlafaxinum |
| Venlafaxinum |
| Formula chemica | C17H27NO2 |
| Massa molaris | 277.402 g/mol |
| Natura pharmacologica |
| Codex ATC | N06AX16 (WHO) |
| Tempus semivitae biologicum | 9-13 h |
| Metabolismus | iecore (hepaticus):CYP2D6, CYP3A4 |
| Metabolitus | Desmethyl-venlafaxinum |
| Excretio | renibus (85%),non mutata (5%),Des-Venlafaxinum(29%) |
| Ad usum therapeuticum |
| Applicatio | per os |

**Venlafaxinum** est substantia psychoanaleptica et antidepressiva et propterea medicamentum, quod cogitari potest, ad therapiam depressionum.

Intellegitur, effectus suos imprimis transportatoribus et serotonini (SERT) et noradrenalini causari: Minoribus in dosibus primo multitudo neurotransmissoris serotoni aucta videatur, cum autem incremento dosis consumptae demum noradrenalini effectus accedant.

Quoque metabolitus suus, *Desmethyl-Venlafaxinum*, efficax sit.

Natura Venlafaxini
------------------

### Natura chemica

Enantiomeres venlafaxini, (S)-forma (sub sinistra) et (R)-forma (sub dextra).
Venlafaxinum est phenylaethylaminum cuius structura chemica (RS)-1-[2-dimethylamino-1-(4-methoxyphenyl)aethyl]cyclohexan-1-olum et massa molaris 277.40 g/mol est.

Venlafaxino duo enatiomera sunt: R-Venlafaxinum et S-Venlafaxinum.

### Natura pharmacologica

### Pharmacodynamica

Venlafaxinum imprimis inhibitor reabsorptionis serotonini affinitate sui notate cum transportatore serotonini (*SERT*) deinde inhibitor noradrenalini reabsorptionis (per transportatorem noradrenalini (NET) ) est. Affinitate aliquanto maius transportatoris serotonini (SERT) quam noradrenalini (NET) venlafaxinum in dosibus parvis naturam inhibitoris serotonini imprimis sed cum augente dosis noradrenalini quoque ostendit. In summa venlafaxinum inhibitor reabsorptionis serotonini noradrenalinique est. 

| Receptorium | Venlafaxini affinitas ligandi*K*i (nM) | Annotationes |
| --- | --- | --- |
| Transportator serotonini (SERT) | 27 (- 82) |  |
| Transportator noradrenalini (NET) | 535 (- 2480) | Ratio Ki(NET)/Ki(SERT) est 20 (-30) |

Adhuc venlafaxinum sub codicibus ATC N06AX, qui *alia antidepressiva* continent. Substantia vero est inhibitor reabsorptionis et serotonini et noradrenalini, categoria cuius nondum exstructa est.

### Pharmacocinetica

Tempus semivitae biologicum {\displaystyle t\_{\frac {1}{2}}} est circa 5 horae. Venlafaxinum substratum cytochromatum CYP2D6 et CYP3A4 est. Metabolitus activus inter alios est O-Desmethyl-venlafaxinum, sive medicamentum Desvenlafaxinum. Excretio Venlafaxini est per urinas (87%).

* DesvenlafaxinumDesvenlafaxinum

Effectus Venlafaxini
--------------------

### Effectus secundarii

**Saepissmime** (>10%) 

* Capitis dolor
* Nausea
* Insomnia
* Asthenia (infirmitas)
* Caligo
* Perturbationes eiaculationis
* Somnolentia
* Siccitas oris
* Sudare

**Rarius**

* Hyponatraemia

Nexus interni
-------------

* Depressio
* Milnacipranum
* Pharmacologia

Notae
-----

1. ↑
2. 1 2  Bymaster FP, Dreshfield-Ahmad LJ, Threlkeld PG, Shaw JL, Thompson L, Nelson DL, Hemrick-Luecke SK, Wong DT (2001). "Comparative Affinity of Duloxetine and Venlafaxine for Serotonin and Norepinephrine Transporters in vitro and in vivo, Human Serotonin Receptor Subtypes, and Other Neuronal Receptors". *Neuropsychopharmacology* **25**: 871-80
3. ↑  Fons.