reapxdev/zenodo-scraper huggingface dataset:
CÂNCER DE MAMA TRIPLO NEGATIVO EM PACIENTES TRATADAS COM QUIMIOTERAPIA BASEADA EM CARBOPLATINA: AVALIAÇÃO DA RESPOSTA PATOLÓGICA
Authors: MARIA JÚLIA DE SOUZA SAMPAIO, ALINE KIMBERLY ALMEIDA RODRIGUES MONTEIRO, ANNA GIULIA PINHEIRO FERREIRA, CAUÃ KILDERY FAUSTINO DE PAULO, ROBERTO CÉSAR PEREIRA LIMA-JÚNIOR
Type: Conference paper
Published: 2026-08-03
Keywords: Câncer de Mama, Quimioterapia, Carboplatina, Obesidade

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<p><strong>Introdução:</strong> O câncer de mama triplo negativo (CMTN) é um subtipo agressivo e de pior prognóstico, caracterizado pela ausência de receptores hormonais e da proteína HER2. Devido à alta taxa de renovação celular, apresenta boa resposta à Quimioterapia Neoadjuvante (QTNeo). A adição de carboplatina, um agente alquilante, tem mostrado melhores desfechos.</p>
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<p><strong>Objetivo:</strong> Avaliar a resposta patológica completa (RPC) em pacientes tratadas com QTNeo com ou sem carboplatina associada em contexto de obesidade. Métodos: Estudo retrospectivo, caso-controle, baseado em prontuários e biópsias tumorais. Foram incluídas 90 pacientes com CMTN estádios II e III atendidas no Hospital Haroldo Juaçaba (HHJ) entre 05/2019 e 08/2025, tratadas com QTNeo padrão (antraciclina + ciclofosfamida/taxano – AC-T) ou com carboplatina associada. O estudo foi aprovado pelo comitê de ética do HHJ (CEP: Número do Parecer: 5.614.936).</p>
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<p><strong>Resultados e Discussão:</strong> Foram analisadas 90 pacientes com câncer de mama triplo negativo, das quais 26 (28,9%) receberam esquemas contendo carboplatina. A resposta patológica completa (RPC) foi avaliada em 60 pacientes, com taxa global de 35,0% (21/60). Entre as pacientes tratadas com carboplatina, a taxa de RPC foi de 50,0% (5/10), enquanto no grupo submetido a outros esquemas foi de 32,0% (16/50), evidenciando maior proporção de resposta no grupo que utilizou carboplatina. Em relação ao índice de massa corporal (IMC), pacientes com RPC apresentaram IMC médio semelhante àquelas sem resposta completa tanto no grupo carboplatina (27,06 vs 24,28 kg/m²) quanto nos demais esquemas (28,73 vs 27,73 kg/m²). Observou-se predominância de sobrepeso e obesidade em ambos os grupos, sem diferença evidente na distribuição do IMC entre pacientes com e sem RPC.</p>
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<p><strong>Conclusão:</strong> O impacto da carboplatina sobre a RPC não pôde ser determinado devido ao tamanho amostral reduzido. Futuramente, a análise de marcadores moleculares poderá auxiliar na identificação do perfil de resposta e de toxicidades em subgrupos de pacientes em uso da carboplatina. Apoio: CNPq, Ebserh, Funcap, ICC</p>
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Perfis de adipocitocinas em pacientes com câncer de mama e controles: análise comparativa e valor diagnóstico
Authors: Gisely de Lima Freitas, Aurilene Gomes Cajado, Lais Saraiva Cruz, Roberto Cesar Pereira Lima Junior, Deysi Viviana Tenazoa Wong
Type: Conference paper
Published: 2026-08-03
Keywords: OBESIDADE, CÂNCER DE MAMA, QUIMIOTERAPIA

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<p><strong>Introdução:</strong> As adipocitocinas, substâncias secretadas pelo tecido adiposo, têm se destacado pelo papel potencial na carcinogênese mamária, mediando interações complexas entre obesidade, inflamação crônica e progressão do câncer de mama (CM). Esse microambiente inflamatório favorece alterações metabólicas e imunológicas que podem impactar tanto o desenvolvimento tumoral quanto a resposta terapêutica. Nesse contexto, destaca-se a resistina, uma adipocitocina pró-inflamatória associada à resistência à insulina, à ativação de vias e à proliferação celular, sendo considerada um potencial elo entre obesidade e câncer.</p>
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<p><strong>Objetivo:</strong> Comparar os níveis séricos de adipocitocinas em pacientes com CM e mulheres sem a câncer, investigando seu desempenho diagnóstico.</p>
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<p><strong>Métodos:</strong> Este estudo, aprovado pelo Comitê de Ética (4.664.756), caracteriza-se como transversal, composto por dois grupos: pacientes diagnosticadas com CM atendidas em centros oncológicos do Ceará e mulheres sem diagnóstico de CM, voluntárias doadoras de sangue do Centro de Hematologia e Hemoterapia do Ceará. Ambos os grupos realizaram coleta de 10mL de sangue periférico para dosagem de resistina, leptina e adiponectina por imunoenzimático do tipo ELISA (Enzyme-Linked Immunosorbent Assay).</p>
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<p><strong>Resultados: </strong>Os níveis das adipocitocinas foram expressos em média ± desvio padrão e comparados pelo teste t de Student. O desempenho diagnóstico foi avaliado por curva ROC (AUC), com cálculo de sensibilidade, especificidade e acurácia. A idade média das pacientes com câncer foi 50,2 (±12,02) anos e das controles 34,83 (±7,49). Os níveis de resistina estavam significativamente elevados no grupo câncer (3401,54 ± 897,48) em comparação aos controles (1666,67 ± 1170,73; p < 0,001), apresentando excelente capacidade discriminatória (AUC=0,863), com sensibilidade de 82,7% e especificidade de 72,1%. A leptina também se mostrou aumentada nos casos de CM (2,44 ± 1,23) em relação ao controle (1,75 ± 1,03; p < 0,001), com acurácia moderada (AUC=0,723). A adiponectina não apresentou diferença estatisticamente significativa entre os grupos (p=0,3; AUC=0,659).</p>
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<p><strong>Conclusão:</strong> A análise dos perfis de adipocitocinas demonstra que a resistina se destaca como principal marcador diferencial entre pacientes com CM e controles, seguida pela leptina. Esses achados reforçam o papel dessas biomoléculas na fisiopatologia tumoral mamária e apontam seu potencial como ferramentas complementares no diagnóstico e estratificação de risco, especialmente em contextos clínicos associados à obesidade e inflamação crônica.</p>
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AVALIAÇÃO DO EFEITO TRIPANOCIDA DA COMBINAÇÃO ENTRE O BENZNIDAZOL E PEPTÍDEOS DERIVADOS DO FRAGMENTO M-PONTx-Dq4e [1-10] EM CEPA Y DE T. cruzi
Authors: Bruna Viana Barroso Martins, Beatriz Maria Silva Martins, Bruna Penin Silva, Ramon Róseo Paula Pessoa Bezerra de Menezes, Alice Maria Costa Martins
Type: Conference paper
Published: 2026-08-03
Keywords: Doença de Chagas, Peptídeos Antimicrobianos, Sinergismo Farmacológico

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<p><strong>Introdução:</strong> A doença de Chagas ocorre em mais de 21 países, em áreas urbanas e rurais. O benznidazol (BZN) é o principal fármaco disponível para tratamento, mas apresenta um longo esquema posológico e eficácia limitada. Uma alternativa promissora é o sinergismo farmacológico, que consiste no aumento no efeito quando duas ou mais substâncias são usadas juntas, em comparação aos efeitos isolados, gerando redução na dose e maior eficácia do tratamento.</p>
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<p><strong>Objetivos:</strong> Avaliar o efeito tripanocida da combinação entre BZN e peptídeos derivados do fragmento M-PONTx-Dq4e [1-10] em cepa Y de T. cruzi.</p>
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<p><strong>Métodos:</strong> As combinações avaliadas foram: peptídeo P37 ([R3,R8,R10], R = arginina) + BZN; P38 ([H4], H = histidina) + BZN; e P39 ([R4]) + BZN. Os experimentos foram conduzidos em triplicata (n = 3), com contagem após 24 horas. Os dados foram analisados no software Combenefit, ferramenta que permite visualizar e analisar a quantificação dos efeitos de combinação entre fármacos, utilizando o modelo de independência de Bliss. Foi realizado ensaio de contagem de formas tripomastigotas tratadas e não tratadas, utilizando concentrações a partir da IC<sub>50</sub>/2: P37 (4,56 µM; 2,28 µM; 1,14 µM; 0,57 µM; 0,29 µM; 0,15 µM; 0,075 µM; 0,0375 µM); P38 (4,60 µM; 2,30 µM; 1,15 µM; 0,58 µM; 0,29 µM; 0,15 µM; 0,075 µM; 0,0375 µM); P39 (6,78 µM; 3,39 µM; 1,70 µM; 0,85 µM; 0,43 µM; 0,22 µM; 0,11 µM; 0,055 µM); e BZN (238,95 µM; 119,48 µM; 59,74 µM; 29,87 µM; 14,93 µM; 7,47 µM; 3,73 µM; 1,87 µM).</p>
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<p><strong>Resultados e Discussão:</strong> Foram observadas áreas de sinergismo em diferentes concentrações para todos os peptídeos, com destaque para combinações envolvendo baixas concentrações peptídicas associadas a diferentes concentrações de BZN. Os maiores picos de sinergismo observados foram nas combinações P37 + BZN (2,28 µM + 59,74 µM; 2,28 µM + 14,93 µM; 2,28 µM + 1,87 µM; 1,14 µM + 29,87 µM); P38 + BZN (0,15 µM + 59,74 µM; 2,30 µM + 59,74 µM; 2,30 µM + 29,87 µM; 2,30 µM + 3,38 µM); e P39 + BZN (0,22 µM + 1,87 µM; 3,39 µM + 14,93 µM; 3,39 µM + 1,87 µM; 0,22 µM + 7,47 µM). Esses achados sugerem potencial redução da dose do fármaco quando utilizado em associação.</p>
<p><strong>Conclusão:</strong> Os peptídeos avaliados apresentam atividade tripanocida e potencial para uso em combinação com o benznidazol no tratamento da doença de Chagas. No entanto, são necessários estudos adicionais para avaliação da citotoxicidade das combinações, para garantir a segurança na administração terapêutica.</p>
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Best Practices for Steady-State scCO2–Brine Relative Permeability Measurements
Authors: Ansaribaranghar, Naser, Shahosseini, Hamidreza, Basafa, Mahsan, Mahmoodi, Maziyar, Yu, Yueping, Romero Fragoso, Alejandro, Abiashue, Lucky, James, Lesley A.
Type: Conference paper
Published: 2026-08-03
Keywords: 2026 SCA, Oral, Subsurface Storage

<p>Accurate steady-state supercritical CO2 (scCO2)–brine relative permeability (kr) data is essential <br>for reliable CCUS storage studies, but obtaining high-quality experimental measurements and converting <br>them into dependable kr curves presents significant challenges. We present a comprehensive best-practice <br>workflow for generating reliable steady-state kr in scCO2–brine systems utilizing a closed-loop high<br>pressure, high-temperature (HPHT) architecture. Unlike much of the existing steady-state gas–brine kr <br>literature, which often reports only a subset of critical QC steps or compares datasets generated with different <br>equipment and saturation-history designs, this work consolidates a complete HPHT workflow. We provide <br>detailed guidance on all aspects of steady-state scCO2–brine coreflooding, including: core handling and <br>preparation; porosity and absolute permeability measurement; leak detection and system volume calibration; <br>CO2 and brine conditioning and equilibration; fluid-property measurement; maintaining pressure<br>temperature stability; designing fractional-flow sequences to achieve near-equal saturation spacing; <br>selecting appropriate flow rates; correcting pressure tare/zero-offset for ΔP measurements; performing <br>multi-rate checks to identify and correct capillary end effects; configuring ΔP taps/measurements and <br>selecting transducers; choosing and tuning backpressure regulators; and operating and calibrating separators. <br>We demonstrate the workflow through drainage → imbibition → secondary drainage cycles to evaluate <br>hysteresis and repeatability, applying rigorous steady-state acceptance criteria based on simultaneous <br>stabilization of differential pressure, phase flow rates, and separator-derived saturation trends. We also <br>present an uncertainty framework that accounts for errors in differential pressure, rate measurements, fluid <br>properties, and separator-level volume readings, allowing these uncertainties to be propagated into the final <br>kr values. This workflow enhances reproducibility and ensures that steady-state scCO2–brine kr data is ready <br>for direct use in CCUS simulators. </p>
Experimental Investigation of Bio-Reactive Transport at the Continuum Scale for Underground Hydrogen Storage
Authors: Stiedl, Gerald, Jasek, Patrick, Ott, Holger
Type: Conference paper
Published: 2026-08-03
Keywords: 2026 SCA, Oral, Subsurface Storage

<p>This study examines dispersive and bio-reactive transport processes in porous rock relevant to <br>underground hydrogen storage and in-situ methanation. Experiments were conducted in a custom-designed <br>core flooding facility equipped with medical X-ray computed tomography (CT) and gas chromatography <br>(GC) to characterize reactive transport in sandstone core samples. Reservoir conditions were replicated by <br>cultivating anaerobic methanogenic microorganisms in a reactor and subsequently inoculating the cores. A <br>series of dispersion experiments was performed to investigate mixing between resident and injected gas <br>phases. The presence of a water phase increased system complexity by introducing gas solubility effects and <br>reducing gas saturation while modifying heterogeneity (introducing macro tortuous pathways), thereby <br>influencing dispersion and the local composition of the injected gas constituents. For the dry H2-N2 system, <br>an effective diffusion coefficient of 1.75∙10-7 m²/s was determined. Bio-reactive conversion consumed H₂ <br>and CO₂ while producing CH₄, resulting in methane formation rates of 0.178-0.284 mmol L-1 h-1. Microbial <br>activity further reduced core permeability by approximately 50%, demonstrating the strong coupling <br>between transport processes and microbial methanation. </p>
Experimental Investigation of H2-Brine Relative Permeability in Tight Sandstone for Assessing Underground Hydrogen Storage Efficiency
Authors: Jenei, Bettina, Al-Masri, Wael, Youssef, Souhail, Alwardy, Basil, Hagemann, Birger, Ganzer, Leonhard
Type: Conference paper
Published: 2026-08-03
Keywords: 2026 SCA, Oral, Subsurface Storage

<p>Underground hydrogen storage (UHS) in depleted hydrocarbon reservoirs and other porous formations such as aquifers is increasingly considered a key large-scale energy buffer for supporting intermittent renewable energy systems. Reliable prediction of hydrogen injectivity, migration, trapping, and recovery efficiency requires robust multiphase flow characterisation, particularly H₂ brine relative permeability. However, hydrogen's low density, high diffusivity, and distinct interfacial properties introduce displacement behaviours that differ fundamentally from those of CO₂ or N₂ based analogues. Experimental datasets for H₂ brine systems, especially in tight sandstones, remain scarce due to operational complexity, hydrogen safety constraints, and measurement uncertainties under low permeability conditions. This study presents primary drainage H₂ brine relative permeability measurements on tight sandstone core plugs spanning a permeability range representative of aquifers originated from depleted gas reservoir intervals considered for UHS. Unsteady state core flooding experiments were conducted in a laboratory approved for hydrogen use equipped with detection, ventilation, and safety control systems, with relative permeability curves derived from measured flow rates and brine production using history matching. The resulting functions exhibit pronounced permeability dependence and systematic differences relative to published CO₂-brine and N₂-brine analogue datasets attributable to hydrogen's distinct fluid properties. These findings demonstrate that directly transferring analogue gas brine relative permeability data to UHS simulations may lead to significant predictive errors in injectivity, pressure evolution, and working gas capacity, underscoring the necessity of fluid and permeability specific parameterisation for reliable UHS performance modelling. </p>
Benchmarking Error Mitigation: Artefactual Improvements in Zero-Noise Extrapolation
Authors: Köster, Dominik, Mauerer, Wolfgang
Type: Conference paper
Published: 2026-07-24

<p>This repository contains all scripts, data, and plotting code to reproduce the experiments and figures presented in the paper: <strong>Benchmarking Error Mitigation: Artefactual Improvements in Zero-Noise Extrapolation</strong> (QuBench 2026 @ QCE 2026)</p>
Formal Security Analysis of the Olvid Messenger
Authors: Terzo, Noemi, Cremers, Cas, Gonzalez, Ruben, Schwabe, Peter, Yarom, Yuval, Zhang, Zhiyuan
Type: Conference paper
Published: 2026-08-03
Keywords: Cryptographic Protocols, Protocol Verification, Symbolic Verification, Authenticated Key Exchange, Timing Attacks

<p>This is the artifact for the paper "Formal Security Analysis of the Olvid Messenger" by Noemi Terzo, Cas Cremers, Ruben Gonzalez, Peter Schwabe, Yuval Yarom and Zhiyuan Zhang. The paper provides a first formal security analysis of the cryptographic core of the Olvid secure messaging app. The formal analysis was conducted using the Tamarin prover. The artifact contains a Docker image for the Tamarin protocol models and proofs, as well as the source code to replicate the proof-of-concept for the timing side-channel attack.</p>
Towards Flexible Embedded Disclosure Policies for EUDI Wallets
Authors: Heher, Jakob, Burtscher, Christian, More, Stefan
Type: Conference paper
Published: 2026-08-03

<p>The upcoming EU Digital Identity (EUDI) Wallet aims to reshape identification and authentication across the EU. Users will receive attestations of identity data from issuers, store them in their wallet, and present them to relying parties. To prevent illegitimate access to sensitive attestation data, the EUDI framework introduces access control policies attached to attestations by their issuers; so-called <em>embedded disclosure policies</em> (EDPs). However, the current EDP framework is inflexible and restricted to simple whitelists and roots-of-trust logic.</p>
<p>We improve on the EUDI’s EDP concept, adopting ideas from the literature to build a more dynamic policy-based access control mechanism. We introduce a generic model for flexible, attribute-based access control. We then instantiate such a scheme using DCQL, a query language already established in the EUDI ecosystem. Finally, we also implement and integrate this approach into a real-world EUDI wallet, demonstrating its feasibility.</p>
Don't Stop Receiving: Ensuring Availability of Critical Services on Compromised Mobile Devices
Authors: Van Eyck, Tom, More, Stefan, Draschbacher, Florian, Michiels, Sam, Hughes, Danny
Type: Conference paper
Published: 2025-11-07

<p>The developers of critical networked applications currently relied on kernel-level protections to ensure the timely delivery of critical messages like Wireless Emergency Alert (WEA) or multi-factor authentication (MFA) notifications. However, the increasing complexity of mobile operating system kernels and network stacks increases the attack surface for adversaries to exploit. In this paper, we introduce a system which safeguards network availability for critical mobile applications against powerful attackers. We achieve this by using the Trusted Execution Environment (TEE) found in most mobile devices to host minimal network drivers. Further, we utilize Trusted I/O to ensure that critical messages reach the end-user even if the device’s kernel is compromised. To demonstrate the feasibility of our approach, we provide a PoC implementation that mimics multi-factor authentication. Our Evaluation demonstrates that latency for all applications is reduced by around 21% on a representative mobile platform (ARM Cortex A9), though a significant throughput performance is observed.</p>
Claim against Measurement: Statistical Artefacts in Quantum Error Mitigation Benchmarks
Authors: Köster, Dominik, Mauerer, Wolfgang
Type: Conference paper
Published: 2026-07-24

<p>This repository contains all scripts, data, and plotting code to reproduce the experiments and figures presented in the paper: <strong>Claim against Measurement: Statistical Artefacts in Quantum Error Mitigation Benchmarks</strong> (QCE 2026)</p>
An Ultra-Compact Ku-Band Doherty Power Amplifier with a Single-Footprint Triple Two-Turn Asymmetric Combiner for 6G FR3
Authors: Xu, Jinglong, Liu, Edward, Eleraky, Mohamed, Huang, Tzu-Yuan, Chu, Chenhao, Wang, Hua
Type: Conference paper
Published: 2025-11-14
Keywords: adaptive, biasing, compact combiner, Doherty, efficiency enhacement, load modulation, power amplifiers

<p>[Abstract] This paper presents an ultra-compact Doherty power amplifier (PA) for the 6G Frequency Range 3 (FR3) Ku band applications, featuring a miniaturized single-footprint triple two-turn <span class="MathJax"><span class="math"><span class="mrow"><span class="mo">(</span><span class="texatom"><span class="mrow"><span class="mn">2</span><span class="mo">:</span><span class="mn">2</span><span class="mo">:</span><span class="mn">2</span></span></span><span class="mo">)</span></span></span></span> asymmetric transformer-based Doherty combiner. Implemented in GF22 FDX+, this Doherty PA delivers a P <span class="MathJax"><span class="math"><span class="mrow"><span class="msubsup"><span class="texatom"><span class="mrow"></span></span><span class="texatom"><span class="mrow"><span class="mtext">SAT</span></span></span></span></span></span></span> of 21.51 dBm and a PAE <span class="MathJax"><span class="math"><span class="mrow"><span class="msubsup"><span class="texatom"><span class="mrow"></span></span><span class="texatom"><span class="mrow"><span class="mn">6</span><span class="mtext">dB</span></span></span></span></span></span></span> of 22.17% at 12 GHz. This work reports the smallest Doherty combiner area in the Ku band, occupying only <span class="MathJax"><span class="math"><span class="mrow"><span class="mn">0.032</span><span class="msubsup"><span class="mtext">mm</span><span class="texatom"><span class="mrow"><span class="mn">2</span></span></span></span><span class="mo">(</span><span class="mn">170</span><span class="mi">μ</span><span class="mi">m</span><span class="mo">×</span><span class="mn">190</span><span class="mi">μ</span><span class="mi">m</span><span class="mo">)</span></span></span></span>. The PA also supports the broadest modulation bandwidth among the Ku-band Doherty PAs, handling 64-QAM signals up to 3800 MHz (22.8 <span class="MathJax"><span class="math"><span class="mrow"><span class="mtext">Gb</span><span class="texatom"><span class="mrow"><span class="mo">/</span></span></span><span class="texatom"><span class="mrow"><span class="mi">s</span></span></span></span></span></span>) and 256-QAM signals up to <span class="MathJax"><span class="math"><span class="mrow"><span class="mn">1400</span><span class="mtext">MHz</span><span class="mo">(</span><span class="mn">11.2</span><span class="mtext">Gb</span><span class="texatom"><span class="mrow"><span class="mo">/</span></span></span><span class="texatom"><span class="mrow"><span class="mi">s</span></span></span><span class="mo">)</span></span></span></span>.</p>
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<p>Final version: https://ieeexplore.ieee.org/document/11233928 </p>