VetriScience Laboratories Composure, Calming Support for Dogs Composure calming formula includes colostrum, l-theanine and thiamine; all recognized ingredients to support calmer behavior and relaxation. Composure is clinically shown to work within 30 minutes and lasts up to 4 hours. Composure can be administered on a daily basis or situation specific. It is safe to double or triple the dose to reach the desired effect. This supplement is safe and effective for long term, daily use. Easy to administer chicken liver flavored chew that your pup may think is a treat! Best results occur when given 30 minutes prior to stress causing event. VetriScience products are veterinarian formulated, manufactured in the U.S.A.