Off! Explore Bite and Itch Relief Pen .5 Oz First Aid Antiseptic External Analgesic (3 Pack) OFF! EXPLORE Bite and Itch Relief, when applied soon after an insect bite, begins to work immediately to counteract the effects of bites and stings from bees and wasps, mosquitoes, ticks, hornets, ants, fire ants, deerflies, sand fleas, horseflies, and chiggers.