Adaptil - refill 48ml calm D.A.P. contains an analogue of the natural canine appeasing pheromone. D.A.P. can be used for events both inside and outside the house, such as: travelling in the car, adjusting to a new environments, visiting the vet, hospitalisation, novel and unpredictable situations. Diffuser and Collar last about 4 weeks refillable for multiple uses