Comfort Zone with DAP for Dogs Diffuser and Single Refill (Discontinued by Manufacturer) Reduce signs of stress associated with new puppy or shelter dog adoption or transition from a breeder Reduce signs of stress from loud noises such as fireworks or thunderstorms Clinically proven effective and veterinarian recommended; drug free Contains 1 diffuser and 1 48 mL refill; additional refills sold separately NOT recommended as a sole treatment for separation anxiety NOT recommended for dog aggression problems