Proden - International Dental PlaqueOff Pet Oral Care and Joy Dental Scraper, 60gm Plaque off is made from a natural vegetable strain of maritime algae harvested above Norway and Iceland Simply add a dosage to food Improvements can usually be seen after 3 to 8 weeks of use Not recommended for animals undergoing treatment for hyperthyroidism Daily dosage small dogs up to 25 lbs. & cats 1/2 - 1 scoop medium dogs 25-50 lbs. 1 - 2 scoop large and giant dogs 50+ lbs. 2 - 3 scoops